<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Chavella Avatara</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antithrombotic Effect of Kaempferia galanga L. and Curcuma xanthorrhiza Roxb. on Collagen-epinephrine Induced Thromboembolism In Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antithrombotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Bleeding time</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuma xanthorrhiza Roxb.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia galanga L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Survival rate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1149-1153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Kaempferia galanga&lt;/em&gt; L. and &lt;em&gt;Curcuma xanthorrhiza&lt;/em&gt; Roxb. have been proven to possess antiplatelet activity &lt;em&gt;in vitro&lt;/em&gt;. The aim of this study is to investigate the antithrombotic effect of the rhizome extracts of &lt;em&gt;Kaempferia galanga&lt;/em&gt; L. and &lt;em&gt;Curcuma xanthorrhiza&lt;/em&gt; Roxb in a mouse thrombotic model. &lt;strong&gt;Methods:&lt;/strong&gt; The ethanol extracts of &lt;em&gt;K. galanga&lt;/em&gt; and &lt;em&gt;C. xanthorrhiza&lt;/em&gt; were orally administered with three different doses (7, 14 and 28 mg/20 g BW) in two experimental mouse models. Bleeding time prolongation was observed on mice tail that had been cut and the survival rate of mice was observed after thromboembolism induction by collagenepinephrine. These two experiments were observed after 7 days extracts pre-treatment and compared to the positive control, aspirin. &lt;strong&gt;Results:&lt;/strong&gt; A potent effect of &lt;em&gt;K. galanga&lt;/em&gt; and &lt;em&gt;C. xanthorrhiza&lt;/em&gt; extracts were demonstrated through significant bleeding time prolongation compared to control group. &lt;em&gt;C. xanthorrhiza&lt;/em&gt; extract exhibited better activity than &lt;em&gt;K. galanga&lt;/em&gt; extract. Moreover, both &lt;em&gt;K. galanga&lt;/em&gt; and &lt;em&gt;C. xanthorrhiza&lt;/em&gt; extracts significantly protected mice from thromboembolic death, where the protective effect of &lt;em&gt;C. xanthorrhiza&lt;/em&gt; extract was stronger than &lt;em&gt;K. galanga&lt;/em&gt; extract in a dose-dependent manner.&lt;strong&gt; Conclusion:&lt;/strong&gt; &lt;em&gt;K. galanga&lt;/em&gt; and &lt;em&gt;C. xanthorrhiza&lt;/em&gt; extracts have a potential to be developed as antithrombotic agents against platelet thromboembolism.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1149</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;*, Chavella Avatara&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Laboratory, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>