<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Handayani H.</style></author><author><style face="normal" font="default" size="100%">Renny Novi P.</style></author><author><style face="normal" font="default" size="100%">Andik Ferdiantoro</style></author><author><style face="normal" font="default" size="100%">Afira Febriani S. W.</style></author><author><style face="normal" font="default" size="100%">Rifky Dwi Aditya Iryawan</style></author><author><style face="normal" font="default" size="100%">Diaz Syafrie A.</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Mochammad Aqilah Herdiansyah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Combination Bitter, Ginger, Turmeric Extract in Mice: Acute and Sub Acute Toxicity Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute and Sub Acute Toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50.</style></keyword><keyword><style  face="normal" font="default" size="100%">SIJAKUN (bitter</style></keyword><keyword><style  face="normal" font="default" size="100%">turmeric)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">916-922</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Herbal plants are widely used as traditional medicine for generations. Some of them are bitter, in Indonesian called Sambiloto (&lt;em&gt;Andrographis paniculata&lt;/em&gt;), red ginger in Indonesian called Jahe merah (&lt;em&gt;Zingiber officinale&lt;/em&gt; &lt;em&gt;var rubrum&lt;/em&gt;), and turmeric in Indonesian called Kunyit (&lt;em&gt;Curcuma domestica&lt;/em&gt;). This study tested extracts containing a combination of three ingredients, hereinafter named 'SIJAKUN' extract (SambIloto, JAhe, KUNyit)”. This combination has good benefits for the body, especially as an anti-inflammatory and antioxidant. This study aims to measure the acute and subacute toxic effects of 'SIJAKUN' extract. This is a true experimental study. In the acute toxicity study, the SIJAKUN extract was given to 5 groups of mice a doses of 1000 mg/kg, 2,000 mg/kg, 3,000 mg/kg, 4,000 mg/kg, and 5,000 mg/kg. After being observed for 24 hours, the number of dead mice from each group was counted to calculate the LD50 of the 'SIJAKUN' extract. Whereas in subacute toxicity, 5 groups of mice were given 0.5 ml of CMCNa solution, 'SIJAKUN' extract at doses of 25 mg/kg, 75 mg/kg, 150 mg/kg, and 25 mg/kg ibuprofen, the test substance was given orally once daily for 28 days. Then an examination was carried out: SGOT, SGPT, BUN, and serum creatinine. the results of subsequent examinations were analyzed statistically. To assess the safety of the SIJAKUN combination, it is necessary to conduct research to determine the acute and sub acut toxicity of SIJAKUN to the liver and kidneys. Based on the results of acut toxixity study conducted, no experimental animals died at one dose of 1000, 2000, 3000, 4000 and 5000 mg/kgbb ‘SIJAKUN’ extract. Based on these results, the LD50 of 'SIJAKUN' extract was above 5000 mg/kgbb. Therefore, it can be said that 'SIJAKUN' extract is a non-toxic compound. In the subacute toxicity study, examination result of SGOT, SGPT, BUN, and serum creatinin was not change significantly, with P value &amp;gt; 0.05. This result indicating no significant difference between the control group and the treatment group. It can be said that the sub-acute toxicity test found that 'SIJAKUN' extract did not toxic for liver and kidney. In acute and subacute toxicity studies that has been carried out, 'SIJAKUN' extract was classified as a non-toxic compound, so it is safe to use as herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Handayani H.&lt;sup&gt;1&lt;/sup&gt;, Renny Novi P.&lt;sup&gt;1&lt;/sup&gt;, Andik Ferdiantoro&lt;sup&gt;1&lt;/sup&gt;, Afira Febriani S. W.&lt;sup&gt;1&lt;/sup&gt;, Rifky Dwi Aditya Iryawan&lt;sup&gt;1&lt;/sup&gt;, Diaz Syafrie A.&lt;sup&gt;1&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;2,3*&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;4,5,6,7&lt;/sup&gt;, Mochammad Aqilah Herdiansyah&lt;sup&gt;6,7,8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences,&amp;nbsp;Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and&amp;nbsp;Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Postgraduate School,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences,&amp;nbsp;Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Virtual Research Center for&amp;nbsp;Bioinformatics and Biotechnology, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Division of Research and Development,&amp;nbsp;Jalan Tengah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Science and Technology,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Lalruatfela</style></author><author><style face="normal" font="default" size="100%">P. B. Lalthanpuii</style></author><author><style face="normal" font="default" size="100%">C. Lalrinmawia</style></author><author><style face="normal" font="default" size="100%">K. Lalchhandama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory and Antiallergic Potentials of the Bioactive  Compounds of Ginger</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allergy</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">Histamine Receptor; Leukotriene Receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Modelling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1166-1176</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Allergy is an ever-increasing immune disorder and is often fatal under certain circumstances. Lack of total curative medication prompts the search for various compounds as the lead molecules. Ginger, &lt;em&gt;Zingiber officinale Roscoe&lt;/em&gt;, is a well-established medicinal plant in different traditional practices. Its use as antiallergic or anti-inflammatory agent has been vindicated but the underlying mechanism of action is yet unknown. &lt;strong&gt;Method:&lt;/strong&gt; In this study, we analyzed the phytocompounds characterized from ginger for their binding affinities on cysteinyl leukotriene receptor 1 (CysLTR1) and histamine H1 receptor (H1R) by molecular docking. The molecular interactions were compared against known agonists and antagonists of the two receptors. &lt;strong&gt;Results: &lt;/strong&gt;The data indicate that ginger compounds have high binding affinity for both LTR1 and H1R comparable to those of antiallergic medications. The highest binding affinities were recorded for gingerenone-A (-7.3 kcal/mol) and zingiberol (-7.2 kcal/mol) on LTR1; and gingerenone-A (-8.7 kcal/mol) and α-curcumene (-8.0 kcal/mol) on H1R.&lt;strong&gt; Conclusion: &lt;/strong&gt;In addition to antiallergic activity, molecular predications on the probable biological activities of the ginger compounds show that they can have a variety of medicinal applications including immunomodulatory and anticancer activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1166</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;B. Lalruatfela&lt;sup&gt;1&lt;/sup&gt; , P. B. Lalthanpuii&lt;sup&gt;2&lt;/sup&gt; , C. Lalrinmawia&lt;sup&gt;2 &lt;/sup&gt;, K. Lalchhandama&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;DBT-BUILDER National Laboratory, Pachhunga University College, Mizoram University, Aizawl 796001, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Netty Suharty</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Ethanol Extract of Arbuscular Mycorrhizal Fungi Induced Ginger Rhizome on T47D Breast Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AMF</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1133-1136</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; A study of investigate the cytotoxicity activity of ethanolic extract of ginger (&lt;em&gt;Zingiber officinale&lt;/em&gt; Rosc.) induced with arbuscular mycorrhizal fungi (AMF) against T47D cells line breast cancer have been conducted. &lt;strong&gt;Methods:&lt;/strong&gt; Cytotoxicity were determined using the &amp;ldquo;microtetrazolium (MTT) Assay&amp;rdquo;, by measuring the activity of mitochondrial dehydrogenase in living cells that have ability to convert pale yellow of dissolved MTT to purple formazan product. The extract used at various concentration (0.1, 1.0, 10 and 100 &amp;mu;g / mL. The level of cytotoxic actifity was determined by calculating the inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value that was based on the precentage of cell death after 24 h treatment with the extract. The change of cell morphology were observed by using inverted microscope. &lt;strong&gt;Results:&lt;/strong&gt; The statistic results proved that ethanol extract of AMF induced ginger rhizome could barriers T47D breast cancers significantly at concentrations of 10 &amp;mu;g / mL and 100 ug / mL, with IC&lt;sub&gt;50&lt;/sub&gt; value was 12.5 &amp;plusmn; 3.73 &amp;mu;g / mL. centration of 0.1 &amp;mu;g / mL, 1.0 &amp;mu;g / mL, 10 &amp;mu;g / mL and 100 mg / mL. Results of statistical analysis showed that the ethanol extract of ginger rhizome induced AMF at a concentration of 10 &amp;mu;g / mL and 100 &amp;mu;g / mL was able to inhibit the growth of breast cancer cells T47D significantly. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results showed the ethanol extract of AMF induced ginger rhizome was potential as herbal medicine for cancer-related ailments with IC&lt;sub&gt;50&lt;/sub&gt; value was 12.5 &amp;plusmn; 3.73 &amp;mu;g / mL.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1133</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Netty Suharty, Fatma Sri Wahyuni, Dachriyanus*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy, Andalas University, West Sumatra, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>