<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Henny Lucida</style></author><author><style face="normal" font="default" size="100%">Poppy Agustin</style></author><author><style face="normal" font="default" size="100%">Suhatri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Assay of Quercetin Solid Dispersion as a Potential Nephronprotector in Acute Renal Failure Induced Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute renal failure mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephron-protector</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Solid dispersion</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">907-912</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Quercetin has been used with other nutraceutical components to improve renal function. Its potential to be developed as an active pharmaceutical ingredient, however, is limited by poor aqueous solubility and low rate of dissolution leading to low bioavailability in rats (&amp;lt; 17%) and in human (1%). Solid dispersion of quercetin with PVP K30 has increased its solubility 13.24 times and the amount dissolved (95.12 ± 1.83%) in comparison to pure quercetin. This study aimed to determine the nephron-protection effect of the solid dispersion on Acute Renal Failure (ARF) mice. The animals were divided into 6 groups, normal mice as a negative control group (G1), ARF induced mice as a positive control group (G2), ARF induced mice given pure quercetin 50 mg/kg BW (G3), ARF induced mice given solid dispersion containing 10 mg/ kg BW (G4), 5 mg/kg BW (G5) and 2.5 mg/kg BW (G6) quercetin respectively. The ARF was induced by injection of gentamycin sulphate 100 mg/kg BW for 7 days consecutively. Renal function was monitored by measuring the serum creatinine at day 8&lt;sup&gt;th&lt;/sup&gt;. The protection effect was also observed from the histopathology score of the nephrons. Results showed that ARF induction increased serum creatinine above normal. Solid dispersion doses variations significantly influence the serum creatinine (p &amp;lt; 0.05). The stage of renal impairment based on histopathology score was significantly influenced by the doses of quercetin in solid dispersion (p &amp;lt; 0.05). It was concluded that solid dispersion containing quercetin at doses 2.5 and 5.0 mg/ kg BW respectively did not effective as a nephron-protector. The solid dispersion containing quercetin 10.0 mg/kg BW was effective to reduce the serum creatinine and showed a nephronprotection effect on the ARF induced mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">907</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Henny Lucida&lt;sup&gt;1,&lt;/sup&gt;*, Poppy Agustin&lt;sup&gt;2&lt;/sup&gt;, Suhatri&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics, Faculty of Pharmacy, University of Andalas, Kampus Limau Manih, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Andalas, Kampus Limau Manih, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sachin Annasaheb Nitave</style></author><author><style face="normal" font="default" size="100%">Nilesh B. Chougule</style></author><author><style face="normal" font="default" size="100%">Kailasam Koumaravelou</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Evaluation of Solid Dispersion Tablet of Andrographis paniculata Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">PEG 6000</style></keyword><keyword><style  face="normal" font="default" size="100%">Solid dispersion</style></keyword><keyword><style  face="normal" font="default" size="100%">Soluplus</style></keyword><keyword><style  face="normal" font="default" size="100%">Solvent evaporation technique</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1047-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To enhance solubility of ethanolic extract of &lt;em&gt;Andrographis paniculata&lt;/em&gt; by solid dispersion technique and to perform formulation and evaluation of solid dispersion tablet. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Solid dispersion of &lt;em&gt;Andrographis paniculata&lt;/em&gt; extract has been prepared by solvent evaporation technique using soluplus and PEG 6000. Prepared solid dispersions have been evaluated for various micromeritic properties. The tablets of solid dispersion were prepared by direct compression technique and were evaluated for various physical tests and&lt;em&gt; in-vitro&lt;/em&gt; dissolution study. &lt;strong&gt;Results:&lt;/strong&gt; The study showed that prepared solid dispersion has good flow property and compressibility. The solubility of extract was found to be more from solid dispersion prepared by using soluplus than that of prepared by using PEG 6000. The rate of drug release was found to be higher in acidic buffer at pH 1.2 as compared to that of in phosphate buffer at pH 6.8. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study concludes that the solid dispersion tablet of ethanolic extract of &lt;em&gt;Andrographis paniculata&lt;/em&gt; can be effectively prepared using soluplus by solvent evaporation techniqu&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1047</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sachin Annasaheb Nitave&lt;sup&gt;1,2&lt;/sup&gt;*, Nilesh B. Chougule&lt;sup&gt;1,3&lt;/sup&gt;, Kailasam Koumaravelou&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Centre for Research and Development, PRIST University, Vallam, Thanjavur, 613 403, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Principal, Dr. J. J. Magdum Trust&amp;rsquo;s Anil alias Pintu Magdum Memorial Pharmacy College Dharangutti, 416101, Shirol, Kolhapur, Maharashtra, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Principal, Annasaheb Dange College of Pharmacy, Ashta, Sangli, Maharashtra, INDIA. 4Director, PRIST University, Puducherry Campus, 605007, Puducherry, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>