<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sylvia Utami Tunjung Pratiwi</style></author><author><style face="normal" font="default" size="100%">Titik Tri Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Attenuation of Pseudomonas aeruginosa Virulence by Some Indonesian Medicinal Plants Ethanolic Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-pathogenic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Quorum quenching</style></keyword><keyword><style  face="normal" font="default" size="100%">Quorum sensing inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">983-987</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; One strategy to address the emergence of infectious diseases supported by the increasing cases of microbial antibiotic resistance is the development of anti-pathogenic drugs, a quorum quenching compound(s) capable of inhibiting microbial communication (quorum sensing inhibitor). &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; is one of the most common source of chronic opportunistic infections, which demonstrates the most consistent resistance to antimicrobial agents. Quorum sensing (QS) controls secretion of virulence factors in &lt;em&gt;P. aeruginosa&lt;/em&gt;.&lt;strong&gt; Aim:&lt;/strong&gt; This study aims to discover quorum sensing inhibitors (QSI) from some Indonesian medicinal plants ethanol extract to analyze their inhibitory activities against QS-mediated virulence factors in&lt;em&gt; P. aeruginosa&lt;/em&gt;. &lt;strong&gt;Settings and Design:&lt;/strong&gt; &lt;em&gt;In-vitro&lt;/em&gt; experimental study-laboratory setting &lt;strong&gt;Material and Methods:&lt;/strong&gt; Indonesian medicinal plant ethanolic extracts were tested for their capability to inhibit &lt;em&gt;P. aeruginosa&lt;/em&gt; motility, biofilm formation using microtiter plate method, pyocyanin and LasA production using LasA staphylolytic assay. Statistical analysis used: Statistical significance of the data were determined using one way ANOVA, followed by Dunnett&amp;rsquo;s test. Differences were considered significant with P values of 0.05 or less. &lt;strong&gt;Results:&lt;/strong&gt; Ethanolic extract of &lt;em&gt;T. catappa&lt;/em&gt; leaves and &lt;em&gt;A. alitilis&lt;/em&gt; flower capable to inhibit &lt;em&gt;P. aeruginosa&lt;/em&gt; motility as well as pyocyanin production and biofilm formation. Both extracts also showed capability in reducing LasA protease production. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;T. catappa&lt;/em&gt; and &lt;em&gt;A. alitilis&lt;/em&gt; are an interesting sources of innovative plant derived quorum quenching compound(s), thus can be used in the development of new antipathogenic drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">983</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sylvia Utami Tunjung Pratiwi&lt;sup&gt;1,2*&lt;/sup&gt;, Titik Tri Handayani&lt;sup&gt;1,2&amp;nbsp;&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Centre for Natural Anti-infective Research (CNAIR), Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>