<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Titut Harnanik</style></author><author><style face="normal" font="default" size="100%">Ketut Edy Sudiarta</style></author><author><style face="normal" font="default" size="100%">Rudi Pandapotan Napitupulu</style></author><author><style face="normal" font="default" size="100%">Arif Rahman Nurdianto</style></author><author><style face="normal" font="default" size="100%">Ni Ketut Alit Darmayanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hyperbaric Oxygen in Animal Model of Diabetes Nephropathy: Analysis of Blood Glucose, Proteinuria and Kidney Tissue Necrosis Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Nephropaty</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperbaric Oxygen</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney Tissue Necrosis Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteinuria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1043-1046</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and is the main cause of 20 to 40 times higher mortality compared to diabetes without nephropathy. Therefore, the author wants to prove the effect of hyperbaric oxygen therapy (HBO) on changes in blood glucose levels, proteinuria and kidney tissue necrosis cells in DN animal models. This study used 27 male white rats Rattus Norvegicus strain Wistar, weighing 170 - 220 grams, aged 8-12 weeks, healthy and active, divided into 3 groups, namely the normal rats group (G0), the DN rats without HBO group (G1) and the DN rats with HBO group (G2). Making a DN model with Streptozotocin (STZ) induction 75 mg / kgBW intraperitoneally in a single dose. HBO was performed in a 2.4 ATA pressurized air chamber by inhaling 98% O2 for 3 x 30 minutes interspersed with inhaling normal air for 2 x 5 minutes for 5 consecutive days. The results showed a significant decrease in blood glucose levels p = 0.000 (p &amp;lt;0.05). In proteinuria levels, there was an insignificant decrease p = 0.077 (p &amp;gt; 0.05) in G2 compared to G1. Repair of kidney tissue damage was also indicated by a decrease in necrotic cells by 45.45% in G2 compared to G1. These results prove that HBO can repair kidney damage in DN model mice, so HBO is expected to be used as an additional therapy in cases of diabetic nephropathy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1043</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Titut Harnanik&lt;sup&gt;1,2,*&lt;/sup&gt;, Ketut Edy Sudiarta&lt;sup&gt;1&lt;/sup&gt;, Rudi Pandapotan Napitupulu&lt;sup&gt;1&lt;/sup&gt;, Arif Rahman Nurdianto&lt;sup&gt;1&lt;/sup&gt;, Ni Ketut Alit Darmayanti&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Marine Health, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Naval Health Institute Drs. Med. R. Rijadi S, Phys., Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Niken Indriyanti</style></author><author><style face="normal" font="default" size="100%">Afrillia Nuryanti Garmana</style></author><author><style face="normal" font="default" size="100%">Finna Setiawan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Repairing Effects of Aqueous Extract of Kalanchoe pinnata (Lmk) Pers. on Lupus Nephritis Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Glomerulonephritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Lupus</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteinuria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/522</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">548-552</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Kalanchoe pinnata&lt;/em&gt; (Lmk) Pers (KP) has an immunosuppressive effect on delayed-type hypersensitivity test. Based on it, this research aimed to determine the repairing effects of aqueous extract of KP on lupus nephritis mice and identified its active compound. The KP extract profile was determined using UPLC-QTOF-MS/MS instrument. We examined six mice groups consisting of three curative treatment groups, one standard group receiving prednisone, one preventive group receiving KP extract, and one healthy (healthy and untreated) group. At the end of the experiment, we measured the proteinuria and renal histology parameters. To recognize the active compound in the KP profile, we performed &lt;em&gt;in silico&lt;/em&gt; assays for the flavonoid compounds to bind to the glucocorticoid receptor. We played &lt;em&gt;in silico&lt;/em&gt; tests for the flavonoid compounds to identify the active compound in the KP profile. We found the repairing effect of KP was detected in the kidney, demonstrated by its low proteinuria level and its better tissue structure. In the curative group, the urine protein level and its glomerular inflammation decreased. In the preventive group, the aqueous extract of KP could prevent lupus nephritis manifestations in the kidney. Bryophyllin A is the most active compound of the KP. However, further research is needed to understand the mechanism involved. We conclude, the aqueous extract, especially its bryophyllin A, have beneficial effects in repairing the function and tissue structure of lupus manifestations in mice kidney.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">548</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Niken Indriyanti&lt;sup&gt;1*&lt;/sup&gt;, Afrillia Nuryanti Garmana&lt;sup&gt;2&lt;/sup&gt;, Finna Setiawan&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Mulawarman University, East Kalimantan, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, Bandung Institute of Technology, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Surabaya, East Java, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>