<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nilda Lely</style></author><author><style face="normal" font="default" size="100%">Helmi Arifin</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Inflammatory Effects of Methanol Extract, Hexane, Ethyl Acetate, and Butanol Fraction of Piper crocatum Ruiz &amp; Pav Leaves on Lipopolysaccharide-induced RAW 264.7 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">LPS</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper crocatum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1341-1346</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Piper crocatum&lt;/em&gt; Ruiz &amp;amp; Pav is a traditional Indonesian plant that is empirically used to treat various diseases. Several studies have stated that &lt;em&gt;Piper crocatum&lt;/em&gt; leaves extract has anti-inflammatory effects.&lt;em&gt; Piper crocatum &lt;/em&gt;leaves contain different secondary metabolites alkaloids, flavonoids, tannin-polyphenols, steroids, terpenoids, and saponins. The purpose of this study was to determine the anti-inflammatory effect of &lt;em&gt;Piper crocatum &lt;/em&gt;leaves extract and fraction on the production of nitric oxide in lipopolysaccharideinduced RAW 264.7 cells. Anti-inflammatory effect of methanol extract of&lt;em&gt; Piper crocatum&lt;/em&gt; leaves (MEPC), n-hexane fraction of &lt;em&gt;Piper crocatum &lt;/em&gt;leaves (HFPC), ethyl acetate fraction of &lt;em&gt;Piper crocatum &lt;/em&gt;leaves (EAFPC), and n-butanol fraction of &lt;em&gt;Piper crocatum&lt;/em&gt; leaves (BFPC) against RAW 264 cell macrophages, 7 Lipopolysaccharide-induced (LPS). Extraction of &lt;em&gt;Piper crocatum &lt;/em&gt;leaves was the maceration method. Cell viability was determined by the MTT method in the concentration range of 12.5;25;50;100;200 ug/ mL. The anti-inflammatory effects of MEPC, HFPC, EAFPC and BFPC were tested against nitric oxide (NO) production inhibition in LPS-induced RAW 264.7 macrophage cells. NO levels were determined by the NO Colorimetric Assay Kit as measured by the ELISA plate reader. The viability test of MEPC, HFPC, EAFPC, and BFPC from &lt;em&gt;Piper crocatum&lt;/em&gt; leaves showed the concentrations that gave the percentage of viability above 80% were concentrations of 100, 50, and 25 g/mL. MEPC, HFPC, EAFPC, and BFPC at concentrations of 100, 50, 25 μg/mL could significantly inhibit NO production with p&amp;lt;0.05 (p=0.000). The highest NO production inhibition effect was on EAFPC. MEPC, HFPC, EAFPC, and BFPC have antiinflammatory effects, with the highest effect on EAFPC.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1341</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nilda Lely&lt;sup&gt;1,3&lt;/sup&gt;, Helmi Arifin2, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;, Fatma Sri Wahyuni&lt;sup&gt;2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Student, Faculty of Pharmacy, Universitas Andalas, Padang, Sumatera Barat 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Andalas, Padang, Sumatera Barat 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;STIFI Bhakti Pertiwi Palembang. Jl. Ariodillah III No.22A, RT.27/RW.9, 20 Ilir D. IV, Ilir Tim. I, Kota Palembang, Sumatera Selatan 30128, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">María del Carmen Juárez-Vázquez</style></author><author><style face="normal" font="default" size="100%">Alejandro Zamilpa A</style></author><author><style face="normal" font="default" size="100%">Rosalba León-Díaz</style></author><author><style face="normal" font="default" size="100%">Mariano Martínez-Vázquez</style></author><author><style face="normal" font="default" size="100%">Adolfo López-Torres</style></author><author><style face="normal" font="default" size="100%">Julieta Luna-Herrera</style></author><author><style face="normal" font="default" size="100%">Lilian Yépez-Mulia</style></author><author><style face="normal" font="default" size="100%">Francisco Alarcón-Aguilar</style></author><author><style face="normal" font="default" size="100%">María Adelina Jiménez-Arellanes</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Anti-Inflammatory Potential of the Organic Extracts from Cleoserrata serrata (Jacq.) Iltis.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimycobacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cleoserrata serrata</style></keyword><keyword><style  face="normal" font="default" size="100%">DL50</style></keyword><keyword><style  face="normal" font="default" size="100%">Leishmanicidal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Organic extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1225-1241</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Cleoserrata serrata&lt;/em&gt; is used in Mexican-south traditional medicine to treat chicleros ulcer. The phytochemical profile and the anti-inflammatory effect from four extracts obtained by maceration proccess and of the primary fractions from two extracts are described. In addition, the antioxidant, leishmanicidal and antimycobaterial activities and LD&lt;sub&gt;50 &lt;/sub&gt;from active extracts are reported. Anti-inflammatory activity was evaluated in TPA and carrageenan assays. Ethyl palmitate and γ-sitosterol were detected in Hexanic and CH&lt;sub&gt;2&lt;/sub&gt;Cl&lt;sub&gt;2&lt;/sub&gt; extracts. Same compounds and stigmasta-3,5-dien-7-one, palmitic acid, phytol acetate and phytol were detected in primary fractions from CH&lt;sub&gt;2&lt;/sub&gt;Cl&lt;sub&gt;2&lt;/sub&gt;:EtOH extract. In this and in MeOH extracts a polyphenolmixture was obtained. The MeOH extract was subjected to acid hydrolysis, and kaempferol, quercetin and scopoletin were detected in organic-phase. Polyphenol-mixture and organic-phase (IC&lt;sub&gt;50&lt;/sub&gt;=3730 and 2338 μg/mL) showed moderate antioxidant activity; meanwhile MeOH extract exhibited scarce activity. In carrageenan model, Hexanic extract and polyphenol-mixture showed ED&lt;sub&gt;50&lt;/sub&gt;=131.46 and 64.89 mg/ kg, respectively. Three extracts were active but not-dose-dependent. In TPA-model, CH&lt;sub&gt;2&lt;/sub&gt;Cl&lt;sub&gt;2&lt;/sub&gt; extract and polyphenol-mixture showed ED&lt;sub&gt;50&lt;/sub&gt; &amp;lt;0.79 mg/ear, and three extracts were active, however the effect was not-dose-dependent. CH&lt;sub&gt;&lt;span style=&quot;font-size:10.8333px&quot;&gt;2&lt;/span&gt;&lt;/sub&gt;Cl&lt;sub&gt;2&lt;/sub&gt;:EtOH showed antimycobacterial and leishmanicidal activities. The LD&lt;sub&gt;50&lt;/sub&gt; was &amp;gt;2 g/kg for all extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1225</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;María del Carmen Juárez-Vázquez&lt;sup&gt;1,2&lt;/sup&gt;†, Alejandro Zamilpa A&lt;sup&gt;3&lt;/sup&gt;, Rosalba León- Díaz&lt;sup&gt;4&lt;/sup&gt;, Mariano Martínez-Vázquez&lt;sup&gt;5&lt;/sup&gt;, Adolfo López-Torres&lt;sup&gt;6&lt;/sup&gt;, Julieta Luna- Herrera&lt;sup&gt;7&lt;/sup&gt;, Lilian Yépez-Mulia&lt;sup&gt;8&lt;/sup&gt;, Francisco Alarcón-Aguilar&lt;sup&gt;2&lt;/sup&gt;, María Adelina Jiménez-Arellanes&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Unidad de Investigación Médica (UIM) en Farmacología, UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI (CMN-SXXI), Instituto Mexicano del Seguro Social (IMSS). Av. Cuauhtémoc 330, Col. Doctores 06720, Ciudad de México (CdMx), MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Av. San Rafael Atlixco 186, CdMx 09340, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigación Biomédica del Sur (CIBIS), IMSS, Argentina 1, Col. Centro 062790, Xochitepec, Morelos, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Área de Biología y Salud Integral, Instituto de Investigaciones Biológicas, Universidad Veracruzana. Luis Castelazo s/n. Col. Industrial Ánimas, Xalapa 91190, Veracruz, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Coyoacán 04510, CdMx, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Instituto de Biotecnología, Universidad del Papaloapan. Circuito Central 12200, Col. Parque Industrial, Tuxtepec 68301, Oaxaca, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Departamento de Inmunología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, CdMx 11340, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;UIM en Enfermedades Infecciosas y Parasitarias, UMAE Hospital de Pediatria, CMN-SXXI, IMSS. Av. Cuauhtémoc 330, Col. Doctores 06720, CdMx, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faris Alrumaihi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Garlic and its Active Compounds: A Novel Strategy to Fight Diseases Through Modulating Biological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ajoene</style></keyword><keyword><style  face="normal" font="default" size="100%">Allicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diallyl disulfide</style></keyword><keyword><style  face="normal" font="default" size="100%">Garlic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1463-1474</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Throughout history, many plants and their products have been widely used as medicines for the prevention and treatment of different diseases in many cultures. &lt;em&gt;Garlic (Allium sativum)&lt;/em&gt;, is commonly used as a spice and traditionally used for its medicinal value since ancient times. Recent studies support the effects of garlic and its extracts in a wide range of applications. Due to the presence of sulfur containing compounds, high trace mineral content and enzymes, garlic has been reported to have implications in disease management and play a role as anti-diabetic, anti-microbial, anti-obesity, anti-oxidant and anti-tumor, dyslipidaemia effect, neuroprotective, cardio-preventive and photo-protection effects. It contains various active compound such as allicin, ajoene, diallyl disulfide and S-allyl-cysteine that modulates various biological cascades and prevent the pathogenesis. This review illustrates the role of garlic and their active ingredients in the health management based on in vivo and in vitro studies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1463</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faris Alrumaihi*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Swarna SK</style></author><author><style face="normal" font="default" size="100%">Nivedhitha MS</style></author><author><style face="normal" font="default" size="100%">Vishnu Priya V</style></author><author><style face="normal" font="default" size="100%">Gayathri R</style></author><author><style face="normal" font="default" size="100%">Selvaraj J</style></author><author><style face="normal" font="default" size="100%">Madhan K</style></author><author><style face="normal" font="default" size="100%">Shyamala Devi B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Evaluation of Anti-Inflammatory Potential of Ethanolic Extract of Leaf, Bark and Flower of Tecoma stans with Ibuprofen- An In vitro Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Bark</style></keyword><keyword><style  face="normal" font="default" size="100%">Flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Tecoma stans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1088-1092</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Endodontics has always been indebted to pharmaceutical sciences to provide it with necessary analgesics and anti-inflammatory agents. More specifically, there has always been a need for anti-inflammatory phytotherapeutic agents as the commercially available synthetic anti inflammatory drugs have their own limitations due to undesirable side effects. Hence, novel potent analgesic and anti-inflammatory drugs without considerable side effects from the natural sources are under evaluation. &lt;em&gt;Tecoma stans&lt;/em&gt; (Bignoniaceae) is an ornamental plant found throughout India. It has been shown to have variety of medicinal properties. In the present study, we have shown that potential anti inflammatory activity of different parts of &lt;em&gt;Tecoma stans &lt;/em&gt;(&lt;em&gt;T.stants&lt;/em&gt;) and compared with standard drug. &lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the &lt;em&gt;in vitro&lt;/em&gt; anti inflammatory potential of different parts of &lt;em&gt;T.stans&lt;/em&gt; ethanolic extract and to compare the anti inflammatory activity with standard drug ibuprofen. &lt;strong&gt;Methodology:&lt;/strong&gt; The ethanolic extraction of &lt;em&gt;T.stans’s&lt;/em&gt; bark, leaves and floweres was done as per the standard method. Different concentrations (100, 200, 300, 400 and 500 μg/ml) of the extracts were used for anti-inflammatory activity by inhibition of albumin denaturation. All samples were analyzed in triplicate. The results were statistically analyzed. &lt;strong&gt;Results: &lt;/strong&gt;All the three parts of the plant extract have shown to have anti inflammatory activity in a dose-dependent manner. However, the leaf and flower extracts of &lt;em&gt;T.stans&lt;/em&gt; were found to have 100 percent anti-inflammatory pontential than standard drug ibuprofen. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded from the present findings that T.stants possess anti-inflammatory properties which could be due to presence of active constitutents presen in the plant extracts. Hence,&lt;em&gt; T.stans&lt;/em&gt; may serve as one of the anti inflammatory herbal durgs for Endontic infection-induced inflammation and related to dental diseases. Further studies on the identification of the active principles present in the leaf and flower extract are warranted to assertatin its potentials.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1088</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Swarna SK&lt;sup&gt;1&lt;/sup&gt;, Nivedhitha MS&lt;sup&gt;1&lt;/sup&gt;, Vishnu Priya V&lt;sup&gt;2,&lt;/sup&gt;*, Gayathri R&lt;sup&gt;2&lt;/sup&gt;, Selvaraj J&lt;sup&gt;2&lt;/sup&gt;, Madhan K&lt;sup&gt;2&lt;/sup&gt;, Shyamala Devi B&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Conservative Dentistry &amp;amp; Endodontics, Saveetha Dental College &amp;amp; Hospitals, Saveetha Institute of Medical &amp;amp; Technical Sciences, Saveetha University, Chennai – 600 077, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College &amp;amp; Hospitals, Saveetha Institute of Medical &amp;amp; Technical Sciences, Saveetha University, Chennai – 600 077, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arshad Husain Rahmani</style></author><author><style face="normal" font="default" size="100%">Mohamed Ali Alsahli</style></author><author><style face="normal" font="default" size="100%">Saleh Abdulrahman Almatroodi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Active Constituents of Pomegranates (Punica granatum) as Potential Candidates in the Management of Health through Modulation of Biological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Heptoprotective Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective Effect and Anti-microbial Effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranates</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.109/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">689-695</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Pomegranates fruits have innumerable health benefits and its implication in diseases cure have been widely recognized since ancient time. Moreover, pomegranate fruits, seeds and peels are intensively used in traditional medicine as a natural therapy. It contains numerous valuable ingredients such as flavonoids, ellagitannin, punicalagin, ellagic acid, vitamins and minerals. The principal constituents including punicalagins and ellagitannin are responsible for immeasurable health benefits due to its strong antioxidant activity. Additionally, constituents of pomegranate show health promoting effect through the modulation of physiological and biochemical pathways. Recent evidences suggested that pomegranates fruits, peels and seeds illustrate therapeutics implications in health management via inhibition of free radical effect and modulation of enzymes activity linked with diseases development and progression. In this review, we summarize the therapeutic role of pomegranate fruits, seeds and peels in the health managements based on &lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo &lt;/em&gt;studies.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">689</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arshad Husain Rahmani, Mohamed Ali Alsahli, Saleh Abdulrahman Almatroodi &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Departments of Medical Laboratories College of Applied Medical Sciences, Qassim University, SAUDI ARABIA.&lt;/p&gt;</style></auth-address></record></records></xml>