<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarah S. Ismael</style></author><author><style face="normal" font="default" size="100%">Noor Ahmed M. Waheed</style></author><author><style face="normal" font="default" size="100%">Seema Mahmood Kasim</style></author><author><style face="normal" font="default" size="100%">Yasser Fakri Mustafa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Coumarin-Indole Hybrids as Cytotoxic Candidates:  Synthesis and Antiproliferative Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indole</style></keyword><keyword><style  face="normal" font="default" size="100%">Michael addition</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1105-1111</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cancer is regarded as a nightmare for humanity and a challenging task for medical professionals. Twelve hydrides &lt;strong&gt;(2a-2l)&lt;/strong&gt;, made of trifunctionalized coumarin and various substituted indoles, were created in an effort to realize the hope of a cancer cure. The 4,5-dimethoxysalicylaldehyde and ethyl acetoacetate were combined in a Knoevenagel reaction to create the coumarin component. The construction of the indole component involved converting various aminoindoles through diazotization and Sandmeyer reactions to twelve substituted indoles &lt;strong&gt;(1a-1l)&lt;/strong&gt;. These two components were combined through a Michael addition reaction to create the desired hybrids. Investigating their spectra released from various spectroscopical instruments allowed researchers to determine the 2D molecular frameworks of these hybrids. Studying the survival of nine tumor cell types after treatment with the synthesized hybrids enabled researchers to estimate there in vitro impact as cytotoxic candidates. By checking the cell viability using an MTT marker, it was possible to see that this effect was antiproliferative. The cytotoxicity measurements, IC50 scores, revealed a number of intriguing facts. To start, the synthetic hybrids displayed a relatively similar cytotoxic pattern against the cancerous cell lines under investigation. Second, compared to hybrids with chloride, hydroxyl, or methoxy substituents, fluorinated hybrids are more toxic to cancerous cells. Finally, hybrids with indole substituted at position-6 &lt;strong&gt;(2i-2l) &lt;/strong&gt;have the highest cytotoxicity among those with indole functionalized at position-4 &lt;strong&gt;(2a-2d)&lt;/strong&gt; or position-5 &lt;strong&gt;(2e-2h)&lt;/strong&gt;. From these facts, the authors concluded that hybrids with indole substituted at position-4 can represent potential candidates as antiproliferative applicants. Moreover, hybrid &lt;strong&gt;2i &lt;/strong&gt;may serve as a valuable model for creating potent anti-breast cancer therapies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1105</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sarah S. Ismael*, Noor Ahmed M. Waheed, Seema Mahmood Kasim, Yasser Fakri Mustafa&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pathom Somwong</style></author><author><style face="normal" font="default" size="100%">Chomnapas Chuchote</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Lupeol, a Cytotoxic Compound Against SW620 Cells in the Extracts of Ha-Rak Recipe</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Benchalokawichian</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer Cell Lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ha-Rak</style></keyword><keyword><style  face="normal" font="default" size="100%">Lupeol</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">133-138</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Ha-Rak is an herbal recipe that has been stated by Ministry of Public Health, Thailand to utilize as the herbal medicines for the treatment of fever. The recipe comprises the roots of five plants including&lt;em&gt; Capparis micracantha, Clerodendrum indicum, Ficus racemosa, Harrisonia perforata&lt;/em&gt; and&lt;em&gt; Tiliacora triandra&lt;/em&gt; as its ingredients. &lt;strong&gt;Methods:&lt;/strong&gt; The extracts of Ha-Rak and its five herbal principles were evaluated for their potential on the cytotoxicity against SW620 cancer cell lines using the MTT assay and an active compound, lupeol which was found as a cytotoxic compound in the herbal ingredients of Ha-Rak was further determined. A chromatographic method for investigating that compound in the extracts was developed herein. The analytical method comprised a cholesterol-coated C18 column, a mixture of acetonitrile and methanol (70:30) with a flow rate of 2 mL/min, and a diode-array UV wavelength at 210 nm as a stationary phase, mobile phase, and detector, respectively. &lt;strong&gt;Results: &lt;/strong&gt;The amount of lupeol in the extracts of Ha-Rak and the herbal principles, which possessed cytotoxicity against SW620 cell lines with the IC&lt;sub&gt;50 &lt;/sub&gt;values of 30.10-212.24 μg/mL displayed variously in the range of 4.50-250.62 mg/100g. The difference of the contents among the extracts was noted significantly (&lt;em&gt;P &lt;/em&gt;&amp;lt; 0.05). The correlation between the lupeol contents and their cytotoxic performances on the tested cell lines was observed in our investigation. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings demonstrated that Ha-Rak recipe contains a promising cytotoxic compound, lupeol and it will support the recipe to subject further pharmacological studies on anticancer activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">133</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pathom Somwong&lt;sup&gt;1,&lt;/sup&gt;*, Chomnapas Chuchote&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathumthani, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathumthani, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maissa’ Taleb Shawagfeh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Carthamus tenuis Extracts on the Cell Proliferation of Different Tumor Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Carthamus tenuis</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1332-1339</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Carthamus tenuis&lt;/em&gt; is one of the medicinal plants that was used traditionally to treat skin diseases, hemorrhoids, abortion, infertility. It also showed an immunosuppressive role as well as antifungal, antibacterial, anti-inflammatory activity. Although this plant is widespread, there are few studies about its medical applications. &lt;strong&gt;Objectives: &lt;/strong&gt;This study was done to explore the anticancer activity of this plant. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were dried, grinded and extracted with hexane, ethyl acetate, and methanol. The extracts were applied in different concentrations to cell cultures of breast (MCF-7), colon (HT-29), prostate (PC-3) and colorectal (CaCo-2) cell lines and fibroblast (MRC- 5) was used as a control. The anticancer activity was evaluated by 3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetrazolium (MTT) reduction assay that was measured by spectrophotometer. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that methanol extract significantly (p&amp;lt;0.05) have the highest inhibitory activity on MCF-7, HT-29, PC-3, and CaCo-2 with IC&lt;sub&gt;50&lt;/sub&gt;; (25.52 μg/ml), (17.37 μg/ml), (25.77 μg/ml), (24.49 μg/ml), respectively. Followed by ethyl acetate extract that moderately inhibit cell growth of PC-3 and CaCo-2 with IC&lt;sub&gt;50&lt;/sub&gt;; (28.99 μg/ml) and (21.45 μg/ml), respectively. n-hexane extract showed no significant inhibitory effect on all cell lines; IC&lt;sub&gt;50&lt;/sub&gt; (125.52 -152.34 μg/ml) when compared to Tamoxifen drug activity as a positive control. &lt;strong&gt;Conclusion: &lt;/strong&gt;Results of this study showed the anticancer activity of the plant extracts in four different kinds of cancers that need further study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1332</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maissa’ Taleb Shawagfeh* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Allied Sciences, Zarqa University College, Al-Balqa Applied University, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susha Antony</style></author><author><style face="normal" font="default" size="100%">Kunnambath Krishna Kumar</style></author><author><style face="normal" font="default" size="100%">Jalaja Sudhi Menon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Phyto-Constituents by GC-MS and Anti-Tumour Activity of Garlic Grown in Different Altitude: A Comparative Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Garlic oil</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyto-constituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">350-354</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Garlic (&lt;em&gt;Allium sativum&lt;/em&gt; L.) is most important spice containing highest sources of total phenolic compounds. It has been used as a component of traditional and modern medicine. Pharmacological properties of garlic is mainly depend on its phyto-constituents content, which varies between geographical regions. The aim of this study was to evaluate and compare the phyto-constituents content of garlic sample collected from high ranges of Idukki (Kanthallur) with that of Tamil Nadu (Mettupalayam market) garlic sample. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; garlic clove sample were collected from high ranges of kanthallur region (GSK) and Mettupalayam region (GSM). The garlic oil was extracted from the collected garlic sample by solvent extraction method. The phytochemical study of extracted garlic oil were conducted using standard methods of analysis and subjected GC-MS analysis. Further, the extracted oil samples were studied for their anti-tumour activity against Dalton Lymphoma Cell Lines (DLA) in an &lt;em&gt;in vitro&lt;/em&gt; model. &lt;strong&gt;Results:&lt;/strong&gt; The obtained results revealed that garlic oil of GSK showed highest percentage of yield of oil (1.1%) than garlic oil of GSM (0.6%). The phytochemical screening of GSK indicated the presence of alkaloids and flavonoid, whereas GSM showed presence of alkaloids only. GC-MS analysis of garlic oil study indicated that garlic oil of GSK was found to have eugenol as a novel source compared with garlic oil of GSM. Garlic oil of GSK showed significant anti-tumour activity against DLA cells, compared with garlic oil of GSM.&lt;strong&gt; Conclusion:&lt;/strong&gt; Garlic oil of GSK exhibited potential anti-tumour activity against DLA cells due to presence of eugenol compound as novel source.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">350</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Susha Antony&lt;sup&gt;1&lt;/sup&gt;, Kunnambath Krishna Kumar&lt;sup&gt;1,2,*&lt;/sup&gt;, Jalaja Sudhi Menon&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, St James College of Pharmaceutical Sciences, Chalakudy, Kerala, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;St James Hospital Trust Pharmaceutical Research Centre (DSIR Recognized), Chalakudy, Kerala, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Kerala Agriculture University, College of horticulture, Vellanikkara, Trissur, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author><author><style face="normal" font="default" size="100%">Subehan Lallo</style></author><author><style face="normal" font="default" size="100%">Masteria Yunovilsa Putra</style></author><author><style face="normal" font="default" size="100%">Tri Aryono Hadi</style></author><author><style face="normal" font="default" size="100%">Ibrahim Jantan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial and Cytotoxic Activities of Sponges Collected off the Coast of Togean Islands, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Sponges</style></keyword><keyword><style  face="normal" font="default" size="100%">Togean Islands</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">988-992</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Marine sponges (Porifera: Demospongia) have astonishing structural diversity and broad biological activities.&lt;strong&gt; Aims:&lt;/strong&gt; To evaluate the antibacterial and cytotoxic activities of five sponges collected off the coast of Togean Islands, Indonesia, identified as &lt;em&gt;Spheciospongia inconstan, Melophlus sarasironum, Oceanapia amboinensis, Biemna&lt;/em&gt; sp and &lt;em&gt;Axinella&lt;/em&gt; sp. &lt;strong&gt;Methods and Material:&lt;/strong&gt; All dried sponges materials were extracted by maceration method using methanol and then evaporated by the rotary evaporator to obtain viscous extracts. The determination of antibacterial activity was performed by well agar diffusion method against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Escherichia coli&lt;/em&gt; while the cytotoxic activity was determined by MTT methods on human breast adenocarcinoma (MCF-7) and human colon colorectal carcinoma (HCT-116), followed by determination of the apoptosis mechanism by Annexin V-FTIC assay. &lt;strong&gt;Results:&lt;/strong&gt;&lt;em&gt; M. sarasinorum and Axinella&lt;/em&gt; sp showed strong inhibition against S.aureus and E.coli with the diameter of inhibition of 14.21 &amp;plusmn; 0.92 mm and 14.36 &amp;plusmn; 0.92 mm, and 10.01 &amp;plusmn; 2.65 mm and 12.07 &amp;plusmn; 1.54 mm, respectively. Moreover, they also exhibited potent cytotoxicity on HCT-116 with IC&lt;sub&gt;50&lt;/sub&gt; values of 0.002 and 8.518 &amp;mu;g/mL, respectively. Meanwhile, on MCF-7, only M. sarasinorum showed moderate inhibition with an IC&lt;sub&gt;50&lt;/sub&gt; value of 87.35 &amp;mu;g/mL. Annexin V-FTIC assay clearly showed that the cytotoxic mechanism of &lt;em&gt;M. sarasinorum and Axinella&lt;/em&gt; sp on HCT-116 and MCF-7 was via apoptosis induction. &lt;strong&gt;Conclusion:&lt;/strong&gt; The sponges of &lt;em&gt;M. Sarasinorum and Axinella&lt;/em&gt; sp are undergoing further analysis to identify the active constituents which could be developed as potential antibacterial and anticancer agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">988</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Muhammad Sulaiman Zubair&lt;sup&gt;1*&lt;/sup&gt;, Subehan Lallo&lt;sup&gt;2&lt;/sup&gt;, Masteria Yunovilsa Putra&lt;sup&gt;3&lt;/sup&gt;, Tri Aryono Hadi&lt;sup&gt;3&lt;/sup&gt;, Ibrahim Jantan&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Sciences, Tadulako University, Kampus Bumi Tadulako, Palu, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Centre for Oceanography, Indonesian Institute of Sciences, Jl. Pasir Putih I, Ancol Timur, Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug and Herbal Research Center, Faculty of Pharmacy, National University of Malaysia, Kuala Lumpur, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mukti R Paudel</style></author><author><style face="normal" font="default" size="100%">Mukesh B Chand</style></author><author><style face="normal" font="default" size="100%">Basant Pant</style></author><author><style face="normal" font="default" size="100%">Bijaya Pant</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Antioxidant-Riched Dendrobium longicornu</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dendrobium longicornu</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.81</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">499-503</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Dendrobium longicornu &lt;/em&gt;is a traditional medicinal plant widely used in Asia. It has many bioactive compounds like bibenzyl, phenanthrenes, phenolic compounds. There has been little research in the cytotoxic and antioxidant effects of &lt;em&gt;D. longicornu.&lt;/em&gt; &lt;strong&gt;Aims:&lt;/strong&gt; The aim of this study was to investigate the cytotoxic and antioxidant activities of this plant. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Antioxidant and cytotoxic activity of &lt;em&gt;Dendrobium longicornu&lt;/em&gt; extracts. &lt;strong&gt;Methods and Material:&lt;/strong&gt; The plant extracts were prepared by soxhlet&amp;rsquo;s extractor in organic solvents, acetone and ethanol. The total polyphenol content (TPC) in the extracts was determined spectrophotometrically by the Folin-Ciocalteu method and the total flavonoid content (TFC) by aluminium chloride method. The antioxidant activity was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The cytotoxic activity was evaluated against human brain tumor cells (U251) and cervical cancer cells (HeLa) using MTT assay. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Regression analysis was done for calculation of IC&lt;sub&gt;50&lt;/sub&gt;. Duncan multiple range test and Dunnett test were done to compare the data. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;Dendrobium longicornu &lt;/em&gt;acetonic extract (DLA) showed significantly highest TPC and TFC than &lt;em&gt;Dendrobium longicornu&lt;/em&gt; ethanolic extract (DLE). The antioxidant activity was also significantly higher in DLA followed by DLE. Highest cytotoxicity (i.e., lowest IC&lt;sub&gt;50&lt;/sub&gt; value) was found for the DLA on U251 cells and DLE on HeLa cells. &lt;strong&gt;Conclusions:&lt;/strong&gt; This result concluded that &lt;em&gt;D. longicornu&lt;/em&gt; is a potential source of antioxidant and cytotoxic agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">499</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mukti R Paudel&lt;sup&gt;1&lt;/sup&gt;, Mukesh B Chand&lt;sup&gt;1&lt;/sup&gt;, Basant Pant&lt;sup&gt;2&lt;/sup&gt;, Bijaya Pant&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Central Department of Botany, Tribhuvan University, Kirtipur, Kathmandu, NEPAL&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Annapurna Research Center, Maitighar, Kathmandu, NEPAL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Preetham Jinadatta</style></author><author><style face="normal" font="default" size="100%">Kiran Sundera Raja Rao</style></author><author><style face="normal" font="default" size="100%">Sharath Rajshekarappa</style></author><author><style face="normal" font="default" size="100%">Sujan Ganapathy Pasura Subbaiah</style></author><author><style face="normal" font="default" size="100%">Mruthunjaya Kenganora</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antioxidant and Hepatoprotective Activity of Bridelia scandens (Roxb.)Willd</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bridelia scandens</style></keyword><keyword><style  face="normal" font="default" size="100%">BRL3A</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">ORAC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/392</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">s117-s121</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Natural products are emerging out as potent and alternative therapies for many diseases. Today herbs have become the part of mankind, because of its manifold ways in targeting diseased cells with minimal effects on normal cells and tissues. The present research investigated the &lt;em&gt;in vitro&lt;/em&gt; antioxidant activity and hepatoprotective of &lt;em&gt;B.scandens&lt;/em&gt; leaf. Preliminary phytochemical analysis exhibited the presence of most of the constituent in ethanol extract (BSE). Antioxidant capacity of various extracts of &lt;em&gt;B.scandens&lt;/em&gt; was examined. DPPH assay revealed that ethanol extract has a good antioxidant with IC&lt;sub&gt;50&lt;/sub&gt; value of 31.68&amp;mu;g/ml, whereas standard ascorbic acid with 8.78 &amp;mu;g/ml. BSE revealed dose dependent response with increase in concentration for reducing power assay. ORAC assay directly measured the scavenging capacity and BSE (2485 trolox eq/gm) was found to be potent than other extracts. &lt;em&gt;In vitro&lt;/em&gt; hepatoprotective activity was performed for BSE using MTT assay in BRL 3A cell line, which revealed nontoxic dose with CTC&lt;sub&gt;50&lt;/sub&gt; value more than 1000 &amp;mu;g/ml. At the dose 200 &amp;mu;g/ml, BSE and standard silymarin offered cell protection of 57% and 76 % respectively. Present study concludes that &lt;em&gt;B.scandens&lt;/em&gt; leaf extract possess antioxidant potential and protect the liver cells against CCl&lt;sub&gt;4&lt;/sub&gt; damage. However in vivo studies are being carried out to validate the traditional usage of &lt;em&gt;Bridelia scandens&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s117</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Preetham Jinadatta&lt;sup&gt;1&lt;/sup&gt;*, Kiran Sundera Raja Rao&lt;sup&gt;1&lt;/sup&gt;, Sharath Rajshekarappa&lt;sup&gt;2&lt;/sup&gt;, Sujan Ganapathy Pasura Subbaiah&lt;sup&gt;3&lt;/sup&gt;, Mruthunjaya Kenganora&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Dayananda Sagar College of Engineering, Kumaraswamy Layout, Bangalore-560078, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, M.S. Ramaiah Institute of Technology, MSRIT Post Bangalore 560054, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research and Development Centre, Indusviva International Private Limited, No.7450, Near Navayuga Toll Gate Office, NH-4, Nelamangala, Bangalore &amp;ndash; 562123, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, JSS College of Pharmacy, JSS University, Mysuru-570015 Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rukhsana Abdul Rub</style></author><author><style face="normal" font="default" size="100%">Manohar Janardhan Patil</style></author><author><style face="normal" font="default" size="100%">Areej Abdul Siddiqui</style></author><author><style face="normal" font="default" size="100%">Priyanka Rambhau Ghorpade</style></author><author><style face="normal" font="default" size="100%">Alpana Subhod Moghe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Free Radical Scavenging and Cytotoxic Potential of Celosia argentea</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine shrimp</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitotic index</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">191-197</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oxidative stress due to reactive oxygen species often leads to pathogenesis of chronic diseases such as cancer. Research states that a diet rich in polyphenols renders many health benefits by scavenging such harmful reactive species. &lt;em&gt;Celosia argentea&lt;/em&gt; (Amaranthaceae), a common weed in India has been reported as a potential source of cheap, natural antioxidants due to its phenolic abundance. In this research work efforts were made to identify and screen the phenolic rich fractions of &lt;em&gt;Celosia argentea&lt;/em&gt; for their antioxidant and anticancer potential. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Various solvent fractions with increasing polarity were subjected to total phenolic content, followed by antioxidant assays-DPPH, ABTS and anti proliferative assays- Brine shrimp Bioassay, Antimitotic and MTT assays. &lt;strong&gt;Results:&lt;/strong&gt; IC&lt;sub&gt;50&lt;/sub&gt; value of methanolic fraction for DPPH assay was statistically significant (26.25; &lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001) when compared with ascorbic acid (12.50; &lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001). Also TEAC values for methanolic fraction and BHT (standard) for ABTS assay were similar (2.1; &lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001) Methanolicfraction at 400 &amp;mu;g/ml exhibited strong cytotoxicity (9.0 &amp;plusmn; 0.81; &lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001) against brine shrimps comparable to Methotrexate at 50 &amp;mu;g/ml(10; &lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001) and significantly reduced mitotic index from 96.8 to 38.0 (&lt;sup&gt;***&lt;/sup&gt;P&amp;lt;0.001) which was further confirmed by MTT assay where IC&lt;sub&gt;50&lt;/sub&gt; value of methanolic fraction for SiHa and MCF-7 cells was found to be 28 &amp;mu;g/ml with no cytotoxicity to normal cells proving its anticancer potential. &lt;strong&gt;Conclusion:&lt;/strong&gt; This research proves antioxidant and anticancer potential of phenolic rich fraction of Celosia argentea and suggests it to be useful in cancer management as antifroliferative, chemo preventive and in cancer chemotherapy induced immune suppression and oxidative stress.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">191</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rukhsana Abdul Rub&lt;sup&gt;*1&lt;/sup&gt;, Manohar Janardhan Patil&lt;sup&gt;2&lt;/sup&gt;, Areej Abdul Siddiqui&lt;sup&gt;1&lt;/sup&gt;, Priyanka Rambhau Ghorpade&lt;sup&gt;1&lt;/sup&gt;, and Alpana Subhod Moghe&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1,*&lt;/sup&gt;Department of Pharmacognosy, M.C.E. Society&amp;rsquo;s Allana College of Pharmacy, Camp, Pune-411001,&amp;nbsp;&amp;nbsp;&amp;nbsp; Maharashtra, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Molecular and Cell Biology, MMM&amp;rsquo;s College of Pharmacy, Kalewadi, Pimpri, Pune, Maharashtra, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Molecular and Cell Biology, Rajiv Gandhi Institute of Biotechnology, Bharati Vidyapeeth University, Pune, Maharashtra, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rukhsana Abdul Rub</style></author><author><style face="normal" font="default" size="100%">Manohar Janardhan Patil</style></author><author><style face="normal" font="default" size="100%">Areej Abdul Siddiqui</style></author><author><style face="normal" font="default" size="100%">Priyanka Rambhau Ghorpade</style></author><author><style face="normal" font="default" size="100%">Alpana Subhod Moghe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Free Radical Scavenging and Cytotoxic Potential of Celosia argentea</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine shrimp</style></keyword><keyword><style  face="normal" font="default" size="100%">Mitotic index</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">191-197</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oxidative stress due to reactive oxygen species often leads to pathogenesis of chronic diseases such as cancer. Research states that a diet rich in polyphenols renders many health benefits by scavenging such harmful reactive species. &lt;em&gt;Celosia argentea&lt;/em&gt; (Amaranthaceae), a common weed in India has been reported as a potential source of cheap, natural antioxidants due to its phenolic abundance. In this research work efforts were made to identify and screen the phenolic rich fractions of &lt;em&gt;Celosia argentea&lt;/em&gt; for their antioxidant and anticancer potential. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Various solvent fractions with increasing polarity were subjected to total phenolic content, followed by antioxidant assays- DPPH, ABTS and anti proliferative assays- Brine shrimp Bioassay, Antimitotic and MTT assays. &lt;strong&gt;Results:&lt;/strong&gt; IC&lt;sub&gt;50&lt;/sub&gt; value of methanolic fraction for DPPH assay was statistically significant (26.25; ***P&amp;lt;0.001) when compared with ascorbic acid (12.50; ***P&amp;lt;0.001). Also TEAC values for methanolic fraction and BHT (standard) for ABTS assay were similar (2.1; ***P&amp;lt;0.001) Methanolicfraction at 400 &amp;mu;g/ml exhibited strong cytotoxicity (9.0 &amp;plusmn; 0.81; ***P&amp;lt;0.001) against brine shrimps comparable to Methotrexate at 50 &amp;mu;g/ml(10; ***P&amp;lt;0.001) and significantly reduced mitotic index from 96.8 to 38.0 (***P&amp;lt;0.001) which was further confirmed by MTT assay where IC&lt;sub&gt;50&lt;/sub&gt; value of methanolic fraction for SiHa and MCF-7 cells was found to be 28 &amp;mu;g/ml with no cytotoxicity to normal cells proving its anticancer potential. &lt;strong&gt;Conclusion: &lt;/strong&gt;This research proves antioxidant and anticancer potential of phenolic rich fraction of Celosia argentea and suggests it to be useful in cancer management as antifroliferative, chemo preventive and in cancer chemotherapy induced immune suppression and oxidative stress.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Antioxidant, Brine shrimp, Mitotic index, MTT, Phenolics.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">191</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rukhsana Abdul Rub&lt;sup&gt;*1&lt;/sup&gt;, Manohar Janardhan Patil&lt;sup&gt;2&lt;/sup&gt;, Areej Abdul Siddiqui&lt;sup&gt;1&lt;/sup&gt;, Priyanka Rambhau Ghorpade&lt;sup&gt;1&lt;/sup&gt;, and Alpana Subhod Moghe&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,*&lt;/sup&gt;Department of Pharmacognosy, M.C.E. Society&amp;rsquo;s Allana College of Pharmacy, Camp, Pune-411001, Maharashtra, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Molecular and Cell Biology, MMM&amp;rsquo;s College of Pharmacy, Kalewadi, Pimpri, Pune, Maharashtra, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Molecular and Cell Biology, Rajiv Gandhi Institute of Biotechnology, Bharati Vidyapeeth University, Pune, Maharashtra, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Sammani</style></author><author><style face="normal" font="default" size="100%">Esam Shammaa</style></author><author><style face="normal" font="default" size="100%">Fawaz Chehna</style></author><author><style face="normal" font="default" size="100%">Abdulkader Rahmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The In-Vitro Toxic Effect of The Glycoalkaloids for Some Solanum Species Against The LIM-1863 Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycoalkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">LIM-1863</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanum</style></keyword><keyword><style  face="normal" font="default" size="100%">Viability</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">23-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt; The LIM-1863 Cell Line is one of the colon cancer types considered to be responsible for a high rate of deaths, and the glycoalkaloids being natural substances existing in the &lt;em&gt;Solanum&lt;/em&gt; species have anticancer effects. &lt;strong&gt;Objective &lt;/strong&gt;This research aims at studying the effect of the glycoalkaloids on viability of the LIM-1863 cancerous cells &lt;em&gt;in-vitro&lt;/em&gt;. &lt;strong&gt;Materials and Methods &lt;/strong&gt;The glycoalkaloids in this study are extracted by the ultrasonic waves technique and detecting them by the Thin Layer Chromatography (TLC) in addition to incubating of the LIM-1863 cells with different concentrations of the glycoalkaloids for 48 hours and then assessing of the cell viability using the MTT assay. &lt;strong&gt;Results&lt;/strong&gt; The findings showed that the glycoalkaloids have a toxic effect on the LIM-1863 cells and that half of the inhibiting concentration (IC&lt;sub&gt;50&lt;/sub&gt;) of the &lt;em&gt;Solanum&lt;/em&gt; fruits extract: (&lt;em&gt;Solanum nigrum&lt;/em&gt; L.), (&lt;em&gt;Solanum villosum&lt;/em&gt; Mill.) and (&lt;em&gt;Solanum elaeagnifolium&lt;/em&gt; Cav.) on the LIM-1863 cells have the (164.7, 35.91 and 12.14 &amp;mu;g/ml) values successively.&lt;strong&gt; Conclusion &lt;/strong&gt;The observations indicated that the glycoalkaloids are able to inhibit the colon cancer cell proliferation.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Solanum&lt;/em&gt;, Glycoalkaloids, TLC, LIM-1863, Viability, MTT.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ahmad Sammani&lt;sup&gt;1,*&lt;/sup&gt;, Esam Shammaa&lt;sup&gt;1&lt;/sup&gt;, Fawaz Chehna&lt;sup&gt;2&lt;/sup&gt; and Abdulkader Rahmo&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, University of Damascus, Damascus, Syria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;National Commission for Biotechnology, Damascus, Syria.&lt;/p&gt;</style></auth-address></record></records></xml>