<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdullahi Temitope Jamiu</style></author><author><style face="normal" font="default" size="100%">Christiana Eleojo Aruwa</style></author><author><style face="normal" font="default" size="100%">Ismail Abiodun Abdulakeem</style></author><author><style face="normal" font="default" size="100%">Abdulwakeel Ayokunnun Ajao</style></author><author><style face="normal" font="default" size="100%">Saheed SABIU</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytotherapeutic Evidence Against Coronaviruses and Prospects for COVID-19</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antivirals</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug target</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant metabolites</style></keyword><keyword><style  face="normal" font="default" size="100%">Plants</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1252-1267</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The emergence of the novel β-coronavirus (SARS-CoV-2) and subsequent outbreak of COVID-19, is a global health challenge with no known treatment to date and has culminated in significant morbidity and mortality. This article highlights current understanding on SARSCoV- 2 based on the available scientific evidence on human coronavirus (HCoV) infections, which could offer novel insights and therapeutic targets for SARS-CoV-2, the causative agent of COVID-19. Specifically, the paper presents available phytotherapeutic evidence against pathogenic HCoVs with a view to identifying potent plant-derived antiviral agents that could be developed to aid the fight against coronaviruses and the current COVID-19. Evidently, elucidation of CoV integral proteins such as the spike protein, angiotensin-converting enzyme 2, 3C-like cysteine protease and papain-like protease, as good targets for drug developments has lent credence to the use of medicinal plants or their metabolites as prophylaxis or treatment interventions in CoV infections and holds promising ground for SARS-CoV-2. While some promising phytocompounds are currently under clinical trials for COVID-19, increased research into plants and in-depth characterization of their metabolites could reveal more interesting results that would benefit humanity in its fight against emerging and re-emerging viral infections including the current COVID-19. Overall, given the current body of evidence on the potential development of phytotherapeutics for COVID-19, fears need to be allayed while clinical trials continue. Conclusively, the lockdown and other preventive measures which have been implemented in most parts of the world should be humanely exercised and supported to ensure compliance and safety of lives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdullahi Temitope Jamiu&lt;sup&gt;2&lt;/sup&gt;, Christiana Eleojo Aruwa&lt;sup&gt;1&lt;/sup&gt;, Ismail Abiodun Abdulakeem&lt;sup&gt;3,&lt;/sup&gt; Abdulwakeel Ayokun-nun Ajao&lt;sup&gt;4&lt;/sup&gt; and Saheed Sabiu&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology and Food Technology, Durban University of Technology, P.O. Box 1334, Durban, 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbial, Biochemical and Food Technology, University of the Free State, Bloemfontein 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Sciences, Al- Hikmah University, Ilorin, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park APK, 2006, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Nurul Najiha Othman</style></author><author><style face="normal" font="default" size="100%">Pei Teng Lum</style></author><author><style face="normal" font="default" size="100%">Siew Hua Gan</style></author><author><style face="normal" font="default" size="100%">Shankar Mani</style></author><author><style face="normal" font="default" size="100%">Mahendran Sekar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of Natural Products against Chemotherapy-Induced Cardiotoxicity: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardioprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1180-1189</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cancer is one of the diseases with high mortality rate recorded each year across the world. Its mainstay treatment is chemotherapy although they are largely toxic, causing severe adverse reactions including cardiotoxicity, nephrotoxicity and genotoxicity. Cardiotoxicity is unique to certain chemotherapeutic agents and occur via several mechanisms. It has been hypothesized that co-administration of natural products which may be cardioprotectant, together with chemotherapy can alleviate cardiotoxicity-induced by chemotherapy. &lt;strong&gt;Objectives:&lt;/strong&gt; This review aimed to provide a brief information about the protective effect of natural products against chemotherapy-induced cardiotoxicity &lt;strong&gt;Methods:&lt;/strong&gt; To complete this review, relevant literatures were searched from several scientific databases including Google, Google Scholar, Scopus, Web of Science and Pubmed. &lt;strong&gt;Results: &lt;/strong&gt;In this paper, we have reviewed ten natural products (curcumin, mangiferin, naringenin, quercetin, 6-gingerol, lycopene, resveratrol, apigenin, proanthocyanidins and indole-3-carbinol), which have major influences in attenuating chemotherapy-drug induced cardiotoxicity. Apart from the cardioprotective effects, they tend to confer some synergistic effects with chemotherapeutic agents and therefore have the potential to be used as an adjunct. &lt;strong&gt;Conclusion:&lt;/strong&gt; Though a panel of natural products demonstrate protective effects against cardiotoxicity in cells and animal models, their therapeutic potentials for clinical needs further investigation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1180</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Nurul Najiha Othman&lt;sup&gt;1&lt;/sup&gt;, Pei Teng Lum&lt;sup&gt;1&lt;/sup&gt;, Siew Hua Gan&lt;sup&gt;2&lt;/sup&gt;, Shankar Mani&lt;sup&gt;3&lt;/sup&gt;, Mahendran Sekar&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh - 30450, Perak, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, BG Nagara, Nagamangala, Mandya - 571418, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daniel Rodrigo Cavalcante de Araújo</style></author><author><style face="normal" font="default" size="100%">Luís Cláudio Nascimento da Silva</style></author><author><style face="normal" font="default" size="100%">Wolfgang Harand</style></author><author><style face="normal" font="default" size="100%">Júlia Morais Fernandes</style></author><author><style face="normal" font="default" size="100%">Thaciane da Cunha Soares</style></author><author><style face="normal" font="default" size="100%">Silvana Maria Zucolotto Langassner</style></author><author><style face="normal" font="default" size="100%">Raquel Brandt Giordani</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Alexandre Gomes da Silva</style></author><author><style face="normal" font="default" size="100%">Márcia Vanusa da Silva</style></author><author><style face="normal" font="default" size="100%">Maria Tereza dos Santos Correia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Semi arid area</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.73</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">435-440</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Anadenanthera colubrina&lt;/em&gt; (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of&lt;em&gt; A. colubrina&lt;/em&gt;. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Samples were collected in Catimbau National Park (Bu&amp;iacute;que, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. &lt;strong&gt;Results:&lt;/strong&gt; All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (&amp;rho;: -0.99), EALE (&amp;rho;: -0.81), CHFE (&amp;rho;: -0.81), EAFE (&amp;rho;: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. &lt;em&gt;colubrina&lt;/em&gt;, however these extracts showed more chemical diversity during dry months.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Daniel Rodrigo Cavalcante de Ara&amp;uacute;jo&lt;sup&gt;1&lt;/sup&gt;, Lu&amp;iacute;s Cl&amp;aacute;udio Nascimento da Silva&lt;sup&gt;2&lt;/sup&gt;, Wolfgang Harand&lt;sup&gt;3&lt;/sup&gt;, J&amp;uacute;lia Morais Fernandes&lt;sup&gt;4&lt;/sup&gt;, Thaciane da Cunha Soares&lt;sup&gt;4&lt;/sup&gt;, Silvana Maria Zucolotto Langassner&lt;sup&gt;4&lt;/sup&gt;, Raquel Brandt Giordani&lt;sup&gt;4&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;5&lt;/sup&gt;, Alexandre Gomes da Silva&lt;sup&gt;1&lt;/sup&gt;, M&amp;aacute;rcia Vanusa da Silva&lt;sup&gt;1&lt;/sup&gt;, Maria Tereza dos Santos Correia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Produtos Naturais, Departamento de Bioqu&amp;iacute;mica, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Mestrado em Biologia Parasit&amp;aacute;ria, Universidade CEUMA, Maranh&amp;atilde;o, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Instituto Nacional do Semi-&amp;Aacute;rido (INSA), Para&amp;iacute;ba, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Farm&amp;aacute;cia, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;</style></auth-address></record></records></xml>