<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dessy Arisanty</style></author><author><style face="normal" font="default" size="100%">Nelsi Fitri Hayaty</style></author><author><style face="normal" font="default" size="100%">Dian Ayu Juwita</style></author><author><style face="normal" font="default" size="100%">Almahdy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sub-acute Toxicity Study of The Ethyl Acetate Fraction of Asam Kandis Rinds (Garcinia cowa Roxb.) on the Liver and Renal Function in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Creatinine serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa rinds</style></keyword><keyword><style  face="normal" font="default" size="100%">SGPT</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight ratio of liver and kidney</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.58</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">345-349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study investigated the sub acute toxicity of the ethyl acetate fraction of asam kandis (&lt;em&gt;Garcinia cowa Roxb&lt;/em&gt;) Rinds in mice. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Sub acute toxicity study was carried out by giving orally at dose 500, 1000 dan 2000 mg / kgBW extract to five mice at 21 days. Animals were observed individually for any clinical signs of toxicity or mortality for 14 days. Measured parameters were SGPT levels, serum creatinine levels, weight ratio of liver and kidney. Extract was given orally at dose 500, 1000 and 2000 mg/kgBW for 21 days. Observations were done on day 8th, 15th and 22th using blood serum, liver and kidneys of mice. Data were analyzed by using two-way ANOVA followed by Duncan&amp;rsquo;s Multiple Range Test. &lt;strong&gt;Results:&lt;/strong&gt; The ethyl acetate fraction of &lt;em&gt;G. cowa&lt;/em&gt; at doses 500, 1000 and 2000 mg/kgBW gave significant effect on increasing SGPT levels and decreasing levels of serum creatinine (p &amp;lt;0.05). The length of treatment gave significant effect on decreasing levels of serum creatinine, weight ratio of liver and kidney (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; The dosage of the ethyl acetate fraction of asam kandis rinds provides significant effect on the SGPT and serum creatinine levels of male white mice. The duration of administration of ethyl acetate fraction of asam kandis rinds provides significant effect on serum creatinine levels, the weight ratio of liver and kidney organ of male white mice.&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">345</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Dessy Arisanty&lt;sup&gt;2&lt;/sup&gt;, Nelsi Fitri Hayaty&lt;sup&gt;1&lt;/sup&gt;, Dian Ayu Juwita&lt;sup&gt;1&lt;/sup&gt;, Almahdy&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, West Sumatera, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Andalas University, West Sumatera, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>