<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surya Dwira</style></author><author><style face="normal" font="default" size="100%">Ariska TP</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Cytotoxicity between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against HeLa Cervical Cancer Cell Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia rotunda</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1297-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to compare between ethanol and ethyl acetate rhizome extract of &lt;em&gt;K.rotunda &lt;/em&gt;against HeLa cervical cancer cell &lt;em&gt;in vitro. &lt;/em&gt;&lt;strong&gt;Material and Methods: &lt;/strong&gt;Methods used in this research are test the chemical compound of extracts using Thin Layer Chromatography (TLC) and phytochemical screening test, also cytotoxicity test using MTT assay. &lt;strong&gt;Result:&lt;/strong&gt; Ethyl acetate extract contains flavonoid, alkaloid, tannin, and triterpenoid, while ethanol extract have flavonoid, triterpenoid, and alkaloid. In addition, ethanol extract has strong cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 16,939 μg/ml) while ethyl acetate extract has moderate cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 127,9 μg/ml). Each of extracts showed significant results (p ≤ 0,05) although when compared between concentrations there are several concentrations that are not significant and also small coefficient of determinant values caused by various confounding factors. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of &lt;em&gt;K.rotunda &lt;/em&gt;rhizome extract has the higher cytotoxicity activity compared to ethyl acetate extract of&lt;em&gt; K.rotunda&lt;/em&gt; rhizome extract against HeLa cervical cancer cell.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Surya Dwira&lt;sup&gt;1&lt;/sup&gt;, Ariska TP&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,3,&lt;/sup&gt;*, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Linda Erlina&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kesaktian Manurung</style></author><author><style face="normal" font="default" size="100%">Delmi Sulastri</style></author><author><style face="normal" font="default" size="100%">Nasrul Zubir</style></author><author><style face="normal" font="default" size="100%">Syafruddin Ilyas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Anticancer Activity and in vitro Antioxidant of Flavonoids in Plectranthus amboinicus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1573-1577</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng is a plant that has a high flavonoid content. The leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng contain many flavonoids Chrysoeriol, Cirsimaritin, Eriodictyol, Luteolin, Rutin, Salvigenin, Thymoquinone, Quercetin, Apigenin, and 5-O-Methyl-Luteolin. &lt;strong&gt;Objectives:&lt;/strong&gt; To determine the antioxidant activity and anticancer activity of flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng. &lt;strong&gt;Methods: &lt;/strong&gt;Anticancer activity testing was carried out by in silico against several cancer receptors and antioxidant activity testing was carried out by in vitro using the 1,1-Diphenyl-2-Picryhydrazil method. The results showed that the flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng have similar anticancer activity to the reference molecule at the P-Glycoprotein-1, Cyclin Dependent Kinase-2, and Phosphoinositide-3-Kinase receptors, as well as better anticancer activity than the reference molecule for the Cyclooxygenase-2 and Phosphoenolpyruvate Carboxykinase receptors. &lt;strong&gt;Results: &lt;/strong&gt;The antioxidant activity of the extract gave an Inhibitory Concentration 50% value of 9.77 μg/mL, the flavonoid compounds contained in &lt;em&gt;Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng gave an Inhibitory Concentration 50% value that lower than the extract, which ranged from 6.92 μg/mL to 8.50 μg/mL. Flavonoids in &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour.) Spreng anticancer activity by in silico molecular docking and antioxidant activity by in vitro 1,1-Diphenyl-2-Picryhydrazil method.&lt;strong&gt; Conclusions: &lt;/strong&gt;All the flavonoid compounds contained in the ethanolic extract of&lt;em&gt; Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng leaves exhibit very strong anti-cancer and antioxidant activity, which results in ethanolic extract of&lt;em&gt; Plectranthus amboinicus &lt;/em&gt;(Lour.) Spreng leaves have very strong antioxidant activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1573</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kesaktian Manurung&lt;sup&gt;1,2&lt;/sup&gt;, Delmi Sulastri&lt;sup&gt;3,&lt;/sup&gt;*, Nasrul Zubir&lt;sup&gt;3&lt;/sup&gt;, Syafruddin Ilyas&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Sciences, Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang, Sumatera Barat 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy and Health Sciences, Sari Mutiara Indonesia University, Helvetia Tengah, Medan Helvetia, Medan, Sumatera Utara 20124, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Medicine, Andalas University, Limau Manis, Pauh, Padang, Sumatera Barat 25176, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Mathematic and Natural Sciences, Sumatera Utara University, Padang Bulan, Medan Baru, Medan, Sumatera Utara 20155, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suchita Dubey</style></author><author><style face="normal" font="default" size="100%">M.V. Ramana</style></author><author><style face="normal" font="default" size="100%">Anuradha Mishra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Fatty Acid Profiling and RBC Membrane Stabilization Activity of Seabuckthorn (Hippophae rhamnoides and Hippophae salicifolia) Seed Oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Denaturation</style></keyword><keyword><style  face="normal" font="default" size="100%">RBC Membrane Stabilization</style></keyword><keyword><style  face="normal" font="default" size="100%">Sea buckthorn Seed Oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.56</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">329-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Seabuckthorn (SBT) is one of the most important plants of higher altitude in India and China. SBT seed oil is rich in Poly Unsaturated Fatty Acid (PUFA) which is present in a peculiar ratio capable of combating inflammation. &lt;strong&gt;Objective&lt;/strong&gt;: To compare the physicochemical characteristics, fatty acid profiling and Red Blood Cell (RBC) membrane stabilization activity between two species of SBT seed oil; &lt;em&gt;Hippophae rhamnoides&lt;/em&gt; (HR) and &lt;em&gt;Hippophae salicifolia&lt;/em&gt; (HS) collected from Ladakh and Sikkim, India, respectively. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; GC-MS analysis was performed and effect of SBT seed oil was evaluated against heat and hypotonicity induced haemolysis of RBC. Protein denaturation assay was also conducted to check its probable role in chronic inflammation. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS analysis confirmed the presence of PUFA viz. Alpha linolenic acid (ALA) and Linoleic acid (LA) in SBT seed oil. Both significantly (p&amp;lt;0.05) inhibited heat and hypotonicity induced membrane destabilization in a concentration dependant manner. Maximum percentage inhibition of protein denaturation was observed at 3.6 &amp;mu;g/ml after incubation period of 4 hours. &lt;strong&gt;Conclusion:&lt;/strong&gt; HR and HS have been proved to inhibit membrane destabilization with almost equal efficacy. Their efficacy against heat induced protein denaturation indicates that they may be useful in prevention and/or treatment of chronic inflammation as well. These findings may be attributed to the presence of PUFA. This study has contributed in establishing some preliminary evidence about PUFAs being the mainstay of their anti-inflammatory efficacy. However, &lt;em&gt;in vivo&lt;/em&gt; studies are required to further validate the results of this study.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Suchita Dubey&lt;sup&gt;1*&lt;/sup&gt;, M.V. Ramana&lt;sup&gt;1&lt;/sup&gt;, Anuradha Mishra&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;1&lt;/sup&gt;Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Uttar Pradesh, INDIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, INDIA&lt;/em&gt;.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Srikanth Jeyabalan</style></author><author><style face="normal" font="default" size="100%">Kavimani Subramanian</style></author><author><style face="normal" font="default" size="100%">Uma Maheswara Reddy Cheekala</style></author><author><style face="normal" font="default" size="100%">Chitra Krishnan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro &amp; ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholinesterase</style></keyword><keyword><style  face="normal" font="default" size="100%">ex vivo.</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Noni</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/194</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">900-905</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer&amp;rsquo;s, dementia, seizure and Parkinsonism. &lt;em&gt;Morinda citrifolia&lt;/em&gt; (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. &lt;strong&gt;Objective:&lt;/strong&gt; The present study is focused to identify the neuroprotective activity of &lt;em&gt;Morinda citrifolia &lt;/em&gt;fruit extract (MCFE) on &lt;em&gt;in vitro&lt;/em&gt; and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer&amp;rsquo;s disease. &lt;strong&gt;Methods:&lt;/strong&gt; Acetylcholinesterase inhibition assay was performed by &lt;em&gt;in vitro&lt;/em&gt; &amp;amp; &lt;em&gt;ex vivo&lt;/em&gt; methods as described by Ellman et al.&lt;em&gt; In vitro&lt;/em&gt; antioxidant assay of the extract was performed by DPPH free radical scavenging activity &amp;amp; nitric oxide scavenging activity. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using Graph- Pad Prism software. &lt;strong&gt;Results:&lt;/strong&gt; By performing &lt;em&gt;in vitro&lt;/em&gt; antioxidant assay the IC&lt;sub&gt;50&lt;/sub&gt; value of the standard quercetin was found to be 46.22 &amp;mu;g/ml as compared to the MCFE which has an IC&lt;sub&gt;50&lt;/sub&gt; value of 43.14 &amp;mu;g/ml for DPPH free radical scavenging activity. Similarly the IC&lt;sub&gt;50&lt;/sub&gt; value of the standard ascorbic acid was found to be 81.85 &amp;mu;g/ml as compared to the MCFE which has an IC&lt;sub&gt;50&lt;/sub&gt; value of 148.0 &amp;mu;g/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by &lt;em&gt;in vitro&lt;/em&gt; method and the IC&lt;sub&gt;50&lt;/sub&gt; value of MCFE and neostigmine was found to be 31.84 &amp;mu;g/ml &amp;amp; 19.71 &amp;mu;g/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both &lt;em&gt;in vitro&lt;/em&gt; and&lt;em&gt; ex vivo&lt;/em&gt; techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">900</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Srikanth Jeyabalan&lt;sup&gt;1*&lt;/sup&gt;, Kavimani Subramanian&lt;sup&gt;2&lt;/sup&gt;, Uma Maheswara Reddy Cheekala&lt;sup&gt;3&lt;/sup&gt;, Chitra Krishnan&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Mother Theresa Post Graduate and Research Institute of Health Sciences, Puducherry - 605006, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical chemistry, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai &amp;ndash; 600 116, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>