<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhairav Kumar Pathak</style></author><author><style face="normal" font="default" size="100%">Kamlesh M. Palandurkar</style></author><author><style face="normal" font="default" size="100%">Meenakshi Singh</style></author><author><style face="normal" font="default" size="100%">Anshuman Trigunayat</style></author><author><style face="normal" font="default" size="100%">Amit Singh</style></author><author><style face="normal" font="default" size="100%">Reena Giri</style></author><author><style face="normal" font="default" size="100%">Kiran Rajendra Giri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of In vivo Analgesic and Anti-inflammatory Activity of Oroxyulum indicum, Baicalein, Chrysin with Phytochemical Analysis and Molecular Docking Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baicalein</style></keyword><keyword><style  face="normal" font="default" size="100%">Chrysine</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Oroxylum indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF alpha.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">811-822</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: &lt;em&gt;Oroxyulum indicum &lt;/em&gt;(OIE) is a native medicinal plant that has been widely employed in Ayurvedic medicine for thousands of years. Though studies have been published citing the analgesic and anti-inflammatory activity of &lt;em&gt;Oroxyulum indicum&lt;/em&gt; and chrysin and Baicalein, there has been no comparative study comparing their activittes and confirming them with molecular docking results. Molecular docking study of two phytochemicals Chrysin (PubChem CID 5281607) and Baicalein (PubChem CID 5281605) into the active sites of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Evaluation and validation of Anti-inflammatory and Analgesic effects of a methanolic extract of the stem bark of Oroxylum indicum and its two constituents Chrysin and Baicalein in Charles foster rats with analysis of the phytoconstituent of &lt;em&gt;Oroxyulum indicum &lt;/em&gt;through HRMS analysis. &lt;strong&gt;Methodology: &lt;/strong&gt;UHPLC-HRMS/MS analyses were performed on a Dionex Ultimate 3000 RS Series UHPLC system combined with a Q Exactive Plus High-Resolution Accurate Mass Spectrometry System. Hot plate and Tal flick model are used for screening of analgesic activity. TNF-alpha and IL-6 inflammatory markers were examined. Carrageenan model is used for antiinflammatory analysis. &lt;strong&gt;Result: &lt;/strong&gt;Interesting results has been obtained in the docking studies of Chrysin and Baicalein with COX-1 (PDB ID: 1EQG). The hydrogen bond interaction established between the Chrysin and Baicalein with the important amino acid, includes Arg 120, Tyr 355, Ser 530, Met 522 (Figure 1). The binding free energy of the Chrysin and Baicalein with target COX-1 was found to be -7.88 and -7.26 Kcal/mol. &lt;strong&gt;Conclusion:&lt;/strong&gt; There is marked reduction in the TNF Alpha expression in the OIE group which is followed by Baicalein and Chrysine. The Baicalein group shows the most marked cumulative increase in reaction time for tail flick among all the groups of the intervention group followed by Chrysine and OIE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">811</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bhairav Kumar Pathak&lt;sup&gt;1&lt;/sup&gt;, Kamlesh M. Palandurkar&lt;sup&gt;2&lt;/sup&gt;, Meenakshi Singh&lt;sup&gt;3&lt;/sup&gt;, Anshuman Trigunayat&lt;sup&gt;4&lt;/sup&gt;, Amit Singh&lt;sup&gt;5&lt;/sup&gt;, Reena Giri&lt;sup&gt;6&lt;/sup&gt;, Kiran Rajendra Giri&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Junior Resident, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Biochemistry, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Medicinal Chemistry Department, Faculty of Ayurveda, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Pharmacology, GMC, Akola, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sangeeta Gupta</style></author><author><style face="normal" font="default" size="100%">Amit Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial, Analgesic and Anti - Inflammatory Activity Reported on Tamarindus indica Linn Root Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti- inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Fabaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Tamarindus indica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.70</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">410-416</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Tamarindus indica&lt;/em&gt; (Family- Fabaceae) show various folkloric uses in treatment of various ailments such as rheumatisum, dysentery, jaundice etc. &lt;strong&gt;Aim:&lt;/strong&gt; The research was conducted to investigate its phytoconstituients and various activity such as antimicrobial, analgesic &amp;amp; anti-inflammatary of AETIRE. &lt;strong&gt;Method:&lt;/strong&gt; The antimicrobial activity was performed on 4 bacterial stains containing (&lt;em&gt;B.subtilis, S.aureus, P. aeruginosa &amp;amp; E.coli&lt;/em&gt;) on AETIRE using Disc diffusion method. The Analgesic activity was tested by thermal and chemical induced pain through Hot plate and AAIWT. And carrageenan induced rat paw oedema model is used to evaluate antiinflammatory activity. &lt;strong&gt;Result:&lt;/strong&gt; Phytoconstituients such as tannins, alkaloids, saponins, flavonoids and carbohydrates present in both the extract. The maximum zone of inhibition of about 21mm &amp;amp; 22mm was shown on &lt;em&gt;B.subtilis&lt;/em&gt; strain by both the extract when compared with standard drug (Tetracycline &amp;amp; Gentamycin). In AAIWT and hot plate test the AETIRE of concentration (100, 200 mg/kg) produce significant dose-dependent inhibition of pain response with maximum 54.33% protection against acetic acid induced pain and about 74.83% inhibition against thermally induced pain by the aqueous extract 200mg. &amp;amp; the anti- inflammatory activity shown by AETIRE (100 &amp;amp; 200mg/kg) caused significant dose dependent inhibition of oedema with maximum 45.94% inhibition in the Carrageenan induced rat paw oedema by the AE. &lt;strong&gt;Conclusion:&lt;/strong&gt; Therefore the AE of &lt;em&gt;Tamarindus indica&lt;/em&gt; root was more effective in showing analgesic and anti-inflammatory activity when compared to the standard drug in each model while ethanol extract show effective antimicrobial activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">410</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sangeeta Gupta&lt;sup&gt;1&lt;/sup&gt;, Amit Singh&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Technocrates College of Pharmacy, Piplani, Anand nagar, Bhopal, Madhya Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, The Pharmaceutical College, Samaleshwari vihar, Barpali, Barghar, Orissa, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>