<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Neneng Silfi Siti Ambarwati</style></author><author><style face="normal" font="default" size="100%">Muhammad Arifuddin</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic and Cytotoxicity Evaluation of Indonesia Native Plant of Piper acre Blume Leaves (Piperaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper acre Blume</style></keyword><keyword><style  face="normal" font="default" size="100%">preliminary phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.68</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">400-404</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Piper acre&lt;/em&gt; Blume (Piperaceae) is an Indonesia native plant that is used as a traditional medicine and commonly known as &lt;em&gt;&amp;lsquo;Sirih Hitam&lt;/em&gt;&amp;rsquo; or &lt;em&gt;&amp;lsquo;Sirih Hutan&amp;rsquo;&lt;/em&gt;. The scientific data from the plant is still very limited. The aims of the present study was to know a pharmacognostic, and cytotoxicity of &lt;em&gt;P. acre&lt;/em&gt; Blume leaf. The macroscopic characters showed that the leaves have a characteristic odor, heart-shaped, margin was finely flat, venation was curved, the upper surface was dark green and slippery while the lower surface was pale green and soft. The microscopic characters revealed upper and lower epidermis cells, glandular trichomes, concentric vascular bundle, paracytic stomata. The fluorescence characteristics showed a variety of chemical constituents present in the plant materials. The preliminary phytochemical investigation of various extracts showed the presence of alkaloid, flavonoid, saponin, terpenoid, tannin, carotenoid, and steroid. The physicochemical properties (yield, color, consistency) of the n-hexane, ethyl acetate, and ethanol extract were 31.57% w/w (green concentrated solid), 13,59% w/w (green concentrated solid), and 16.35% w/w (brownish green liquid). Based on the cytotoxicity using brine shrimp lethality assay of the n-hexane extract (2.46 &amp;mu;g/ml), ethyl acetate extract (0.925 &amp;mu;g/ml), and ethanol extract (5.741 &amp;mu;g/ml) showed that the extract had the cytotoxic activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">400</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Islamudin Ahmad&lt;sup&gt;1,3&lt;/sup&gt;, Neneng Silfi Siti Ambarwati&lt;sup&gt;2,3&lt;/sup&gt;, Muhammad Arifuddin&lt;sup&gt;1&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1&lt;/sup&gt;, Abdul Mun&amp;rsquo;im&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Mulawarman University, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health and Beauty, Faculty of Engineering, Jakarta State University, Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>