<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meiliza Ekayanti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Dipeptidyl peptidase IV Inhibitory Activity of Fraction from White Tea Ethanolic Extract (Camellia sinensis (L.) Kuntze) ex vivo</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Camellia sinensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Dipeptidyl peptidase IV</style></keyword><keyword><style  face="normal" font="default" size="100%">DPP IV</style></keyword><keyword><style  face="normal" font="default" size="100%">Fraction</style></keyword><keyword><style  face="normal" font="default" size="100%">White tea.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/418</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">190-193</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Treatment for type-2 diabetes mellitus focuses on the incretin hormone, Glucagon-Like Peptide-1 (GLP-1). However, it has a short half-life. Inhibition of the enzyme Dipeptidyl peptidase IV (DPP IV) required maintaining the active form of GLP-1. Based on the previous studies on the highest activity of DPP IV enzyme inhibition of white tea extract, this study conducted on the fraction of white tea extract using rat blood serum (&lt;em&gt;ex vivo&lt;/em&gt;). &lt;strong&gt;Objectives:&lt;/strong&gt; This study aims to evaluate the inhibitory activity of fraction from white tea extract. &lt;strong&gt;Methods:&lt;/strong&gt; White tea leaves extracted with ethanol. The inhibitory activity determined by using rat blood serum as DPP IV enzyme source (&lt;em&gt;ex vivo&lt;/em&gt;), AMC (7-amino 4-methyl coumarin) as fluorescence substrate of DPP IV and sitagliptin as the standard reference. The the cleavage of fluorescence reaction product observed by a microplate reader with &amp;lambda;&lt;sub&gt;ex&lt;/sub&gt; = 360 nm and &amp;lambda;&lt;sub&gt;em&lt;/sub&gt; = 460 nm at 37&lt;sup&gt;o&lt;/sup&gt;C. Data expressed as mean &amp;plusmn; SD and the IC&lt;sub&gt;50&lt;/sub&gt; value determined by nonlinear regression curve and fit using Prism Graph 7. &lt;strong&gt;Result:&lt;/strong&gt; Methanol fraction (250 &amp;mu;g/mL) has the greater inhibition percentage (50.487%), and the fraction of n-hexane and ethyl acetate are 32.417% and 36.541%. The methanol fraction IC&lt;sub&gt;50&lt;/sub&gt; value is 227 &amp;mu;g /mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanol fraction is the most active to inhibit DPP IV enzyme.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">190</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Meiliza&amp;nbsp;Ekayanti, Rani Sauriasari, Berna Elya*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy, University of Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meiliza Ekayanti</style></author><author><style face="normal" font="default" size="100%">Lia Ardiana</style></author><author><style face="normal" font="default" size="100%">Sarah Zielda Najib</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic and Phytochemical Standardization of White Tea Leaf (Camellia sinensis L. Kuntze) Ethanolic Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characteristic</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Physico-chemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Theaceae.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">221-226</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Tea or also known as &lt;em&gt;Camellia sinensis&lt;/em&gt; (Theaceae family) is the most popular plant and beverage in the world because of the sensory properties, prices are relatively cheap, stimulant effects, and their potential health benefits but white tea is not widely known. White tea is made from unfermented tea leaves young shoots protected from sunlight to avoid polyphenols degradation which inhibits of the chlorophyll formation and causing the white color on the leaf buds. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of research and development of herbal medicine is to improve the quality and safety of natural products. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Macroscopical and microscopical features of the leaf have been analysis using an optical microscope and fragment analysis under scanning electron microscopy (SEM). Phytochemical and physico-chemical analysis were evaluated. The observation of the FTIR spectrum profiles is done by interpreting the typical peak that appears. &lt;strong&gt;Results:&lt;/strong&gt; The leaf has actinocytic stomata, unicellular trichomes, heterogenous mesophyll which is characterized by the presence of calcium oxalate crystals and sclereid cells. Phytochemical analysis indicated resources the presence of tannins, flavonoids, glycosides and saponins.The content of polyphenol from white tea leaves ethanolic extract is 35.73% with the largest concentration of catechins is 18.84% and 17.43% tannins. The derivative content of catechins is EGCG with 7.37%. FTIR analysis showed functional groups of O-H, C-H, N-H, C=O, C=C, and C-O. &lt;strong&gt;Conclusion:&lt;/strong&gt; Pharmacognostic and phytochemicals features established in this study may be used as part of the pharmacopoeial standard which can play an important role in its standardization.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">221</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Meiliza Ekayanti, Lia Ardiana, Sarah Zielda Najib, Rani Sauriasari, Berna Elya* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lia Ardiana</style></author><author><style face="normal" font="default" size="100%">Meiliza Ekayanti</style></author><author><style face="normal" font="default" size="100%">Sarah Zielda Najib</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Acute Oral Toxicity Study of White Tea Leaf (Camellia sinensis (L.) Kuntze) Ethanolic Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Camellia Sinensis (L.) Kuntze</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword><keyword><style  face="normal" font="default" size="100%">Teh Putih</style></keyword><keyword><style  face="normal" font="default" size="100%">Theaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.77</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">479-482</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; White tea is a kind of tea which manufactured with minimal processing only drying without fermentation process. White tea prepared from very young tea leaves or buds of &lt;em&gt;Camellia sinensis&lt;/em&gt; (L.) Kuntze, Theaceae, covered with tiny, silvery hairs, and dried immediately after picking to prevent oxidation and commonly used as a beverage and herbal medicine. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was aimed to evaluate the safety of the white tea leaf ethanolic extract (WTE) with acute toxicity tests. &lt;strong&gt;Methods:&lt;/strong&gt; The acute oral toxicity of WTE performed at dose 1250, 2500, and 5000 mg/Kg BW of Deutschland, Denken, and Yoken (DDY) mice. The animals observation for any mortality, behavioral, body weight and feed-water consumption pattern during the 14- day study. The liver, kidney, and heart isolation performed on day-15 to observe macroscopic and relative organ weight (ROW). &lt;strong&gt;Results:&lt;/strong&gt; No treatment-related toxic symptom or mortality observed for the first 4 hours and 24 hours after oral administration of WTE at a dose of 1250, 2500, and 5000 mg/kg BW. All the groups of mice did not show the significant changes in behavior, breathing, and motoric activity. &lt;strong&gt;Conclusions:&lt;/strong&gt; This studies showed that the oral LD&lt;sub&gt;50&lt;/sub&gt; of WTE was greater than 5000 mg/kg BW and suggests that the WTE is practically non-toxic in a single dose of level 5000 mg/kg BW.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">479</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Lia Ardiana, Meiliza Ekayanti, Sarah Zielda Najib, Rani Sauriasari&lt;sup&gt;*&lt;/sup&gt;, Berna Elya&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy, University of Indonesia, 16424, Depok, INDONESIA&lt;/p&gt;</style></auth-address></record></records></xml>