<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramar Gowtham</style></author><author><style face="normal" font="default" size="100%">Fysal Yousuf MA</style></author><author><style face="normal" font="default" size="100%">Devaraj Ezhilarasan</style></author><author><style face="normal" font="default" size="100%">Shanmugam Sambantham</style></author><author><style face="normal" font="default" size="100%">Balakrishnan Anandan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antifungal Effects of Hesperetin and Silibinin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Candida albicans</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Fungal infection</style></keyword><keyword><style  face="normal" font="default" size="100%">Hesperetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Silibinin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/671</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">789-792</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Increasing resistance of microorganisms against available antimicrobial agents is of major concern among scientists and clinicians worldwide. To overcome the resistance and other drawbacks of the current antimicrobial drugs and to obtain more efficacious drugs, an antimicrobial drug having a novel mode of action should be developed. The flavonoid compounds have demonstrated for their therapeutic potential as antimicrobial agents previously. &lt;strong&gt;Aim:&lt;/strong&gt; To evaluate the antifungal efficacy of plant derived compounds such as hesperetin (HSP) and silibinin (SBN) compounds &lt;em&gt;in vitro&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In this study, we evaluated the antifungal effect of two plant derived flavonoid compounds &lt;em&gt;i.e&lt;/em&gt;., SBN and HSP against &lt;em&gt;Candida albicans, Candida tropicalis, Malassezia furfur, Aspergillus niger, Penicillium oxalicum&lt;/em&gt;. The disk diffusion test was performed to test the antifungal effect of HSP and SBN with three different concentrations &lt;em&gt;i.e.&lt;/em&gt;, 15, 20, 25 mg/ml of HSP and SBN. The antifungal efficacy was studied for 72 h. &lt;strong&gt;Results:&lt;/strong&gt; Our results indicate that SBN has significant antifungal effect than that of HSP. The high sensitivity of these compounds was found against &lt;em&gt;C. albicans, C. tropicalis&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These drugs could be good candidate to combine with regular antimicrobial agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">789</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramar Gowtham&lt;sup&gt;1&lt;/sup&gt;, Fysal Yousuf MA&lt;sup&gt;1&lt;/sup&gt;, Devaraj Ezhilarasan&lt;sup&gt;1&lt;/sup&gt;*, Shanmugam Sambantham&lt;sup&gt;2&lt;/sup&gt;, Balakrishnan Anandan&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, INDIA-600 077.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Genetics, University of Madras, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shenai Ashwini</style></author><author><style face="normal" font="default" size="100%">Devaraj Ezhilarasan</style></author><author><style face="normal" font="default" size="100%">Roy Anitha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caralluma fimbriata</style></keyword><keyword><style  face="normal" font="default" size="100%">COLO 320 cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Colonic cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/301</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">204-207</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; in the COLO 320 cell line. &lt;strong&gt;Materials and Method:&lt;/strong&gt; The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of &lt;em&gt;Caralluma&lt;/em&gt; (100 &amp;ndash; 300 &amp;mu;g/ml) for 24 h. The cell viability and IC&lt;sub&gt;50&lt;/sub&gt; was calculated from the cytotoxicity. The morphology of the &lt;em&gt;Caralluma&lt;/em&gt; treated cells, control, and positive control were observed under reverse phase inverted microscope.&lt;strong&gt; Result:&lt;/strong&gt; The &lt;em&gt;C. fimbriata&lt;/em&gt; ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 &lt;em&gt;&amp;mu;&lt;/em&gt;g with an IC&lt;sub&gt;50&lt;/sub&gt; value of 233.87 &lt;em&gt;&amp;mu;&lt;/em&gt;g. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study shows that the ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shenai Ashwini, Devaraj Ezhilarasan, Roy Anitha* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha University, Chennai-600 077, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>