<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">K Ganesh Shenoy</style></author><author><style face="normal" font="default" size="100%">Nitesh Kumar</style></author><author><style face="normal" font="default" size="100%">Sathish Pai B</style></author><author><style face="normal" font="default" size="100%">Arul Amuthan</style></author><author><style face="normal" font="default" size="100%">Manjunath S Shetty</style></author><author><style face="normal" font="default" size="100%">Sachindra Kumar</style></author><author><style face="normal" font="default" size="100%">Amruth Kiran</style></author><author><style face="normal" font="default" size="100%">Mahesha Keerikkadu</style></author><author><style face="normal" font="default" size="100%">M Hariprasad Kamath</style></author><author><style face="normal" font="default" size="100%">Devasrita Dash</style></author><author><style face="normal" font="default" size="100%">Tatiyana Mandal</style></author><author><style face="normal" font="default" size="100%">K Sreedhara Ranganath Pai</style></author><author><style face="normal" font="default" size="100%">Smita Shenoy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Antipsoriatic Activity of Sivanar Vembu Kuzhi Thailam in an Imiquimod-Induced Psoriasis Model: Phytochemical, Computational, and Experimental Investigations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Psoriasis; Sivanar Vembu Kuzhi Thailam; Network pharmacology; Imiquimod model; Siddha</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">371-384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by epidermal hyperplasia and dysregulated immune responses. Long-term use of the current therapeutic agents is often limited by adverse effects, high costs, and variable efficacy. The present study evaluated the antipsoriatic potential of &lt;em&gt;Sivanar Vembu Kuzhi Thailam&lt;/em&gt; (SVKT), a traditional Siddha formulation, using an imiquimod-induced psoriasis-like mouse model. The drug was subjected to physicochemical characterization, microbiological evaluation, and Gas chromatography–mass spectrometry (GC-MS) analysis to identify its major phytoconstituents. Network pharmacology was performed to explore interactions between bioactive compounds and key psoriasis-associated inflammatory targets. Female BALB/c mice were induced to develop psoriasis-like lesions. SVKT (60, 100, and 200 mg/kg, orally) was administered to test prophylactic and therapeutic efficacy. Disease progression and therapeutic response were assessed using Psoriasis Area and Severity Index (PASI) scoring, histopathological examination, and Baker’s pathological scoring. GC–MS analysis identified 95 compounds. Computational analyses indicated favorable interactions of selected phytoconstituents with TNF-α, IL-17A, IL-1β, and IFN-γ related to psoriasis. SVKT significantly reduced PASI scores, erythema, scaling, and epidermal thickening (p &amp;lt; 0.05), while histopathological evaluation demonstrated restoration of normal skin architecture and reduced inflammatory infiltration. The formulation complied with microbiological safety standards and showed no evidence of toxicity. These findings demonstrate that SVKT might possess significant antipsoriatic, anti-inflammatory, and antioxidant activities, supporting its traditional use and highlighting its potential as a safe, effective, and economical therapeutic candidate for psoriasis management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">371</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;K Ganesh Shenoy&lt;sup&gt;a&lt;/sup&gt;, Nitesh Kumar&lt;sup&gt;b&lt;/sup&gt;, Sathish Pai B&lt;sup&gt;c&lt;/sup&gt;, Arul Amuthan&lt;sup&gt;a&lt;/sup&gt;, Manjunath S Shetty&lt;sup&gt;a&lt;/sup&gt;, Sachindra Kumar&lt;sup&gt;d&lt;/sup&gt;, Amruth Kiran&lt;sup&gt;a&lt;/sup&gt;, Mahesha Keerikkadu&lt;sup&gt;e&lt;/sup&gt;, M Hariprasad Kamath&lt;sup&gt;f&lt;/sup&gt;, Devasrita Dash&lt;sup&gt;a&lt;/sup&gt;, Tatiyana Mandal&lt;sup&gt;a&lt;/sup&gt;, K Sreedhara Ranganath Pai&lt;sup&gt;d&lt;/sup&gt;, Smita Shenoy&lt;sup&gt;g,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Division of Pharmacology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal – 576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education &amp;amp; Research (NIPER), Hajipur, Bihar, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Dermatology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education Manipal – 576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;d&lt;/sup&gt;Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal – 576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;e&lt;/sup&gt;Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;f&lt;/sup&gt;Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Madhav Nagar, Manipal – 576104, Karnataka, INDIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;g&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal – 576104, Karnataka, INDIA.&lt;/p&gt;
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