<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pawan Banduji Itankar</style></author><author><style face="normal" font="default" size="100%">Gaurav Rajendra Sawarkar</style></author><author><style face="normal" font="default" size="100%">Ajitkumar Shashikumar Wahane</style></author><author><style face="normal" font="default" size="100%">Anita Santoshrao Wanjari</style></author><author><style face="normal" font="default" size="100%">Ujwal B. Vyas</style></author><author><style face="normal" font="default" size="100%">Punam Gaurav Sawarkar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Histological and Structural Analysis of Wound Healing with Ehretia laevis Roxb. Tincture Ointment versus Povidone-Iodine Ointment in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ehretia laevis</style></keyword><keyword><style  face="normal" font="default" size="100%">Excision Wound Model</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Povidone-Iodine</style></keyword><keyword><style  face="normal" font="default" size="100%">Preclinical Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">279-285</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Delayed wound healing remains a significant clinical challenge, driving the search for effective and safe therapeutic agents. &lt;em&gt;Ehretia laevis&lt;/em&gt; Roxb. is a medicinal plant traditionally used for various ailments, but its wound-healing properties, particularly in a tincture-ointment formulation, have not been systematically investigated. Aim: Structural analysis of wound healing with &lt;em&gt;Ehretia laevis&lt;/em&gt; Roxb. Tincture ointment versus Povidone-iodine ointment in Wistar rats. Methods: An experimental preclinical study was conducted on 12 Wistar rats divided into two groups (n=6 each). A 10 mm diameter full-thickness excision wound was created on the dorsum. Group A received&lt;em&gt; E. laevis&lt;/em&gt; tincture ointment, while Group B received povidone-iodine ointment, twice daily for 15 days. Wound contraction was assessed on days 7 and 15. Histopathological evaluation was performed on days 1, 7, and 15 using a semi-quantitative scoring system for granulation tissue, inflammatory infiltrate, collagen fiber orientation, and collagen deposition. Data were analyzed using unpaired t-tests, two-way ANOVA, and Mann-Whitney U tests. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;E. laevis&lt;/em&gt; group exhibited significantly higher mean wound contraction on day 7 (71.5 ± 2.4% vs. 60.5 ± 1.7%; p &amp;lt; 0.0001) and day 15 (97.5 ± 2.4% vs. 90.3 ± 3.0%; p &amp;lt; 0.001) compared to the control group. Histopathological analysis revealed that &lt;em&gt;E. laevis&lt;/em&gt; significantly reduced inflammatory infiltrate (p = 0.045) and promoted early collagen deposition (p = 0.035) by day 7. By day 15, the test group showed significantly superior collagen maturation (p = 0.0037) and orientation (p = 0.014), resulting in significantly higher cumulative healing scores (p = 0.0076). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ehretia laevis&lt;/em&gt; tincture ointment demonstrates superior and accelerated wound healing activity compared to povidone-iodine ointment. Its enhanced efficacy, supported by both macroscopic and histological evidence, positions it as a promising novel therapeutic option for wound management and warrants further investigation into its underlying molecular mechanisms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">279</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pawan Banduji Itankar&lt;sup&gt;1&lt;/sup&gt;, Gaurav Rajendra Sawarkar&lt;sup&gt;2&lt;/sup&gt;, Ajitkumar Shashikumar Wahane&lt;sup&gt;3&lt;/sup&gt;, Anita Santoshrao Wanjari&lt;sup&gt;4&lt;/sup&gt;, Ujwal B. Vyas&lt;sup&gt;5&lt;/sup&gt;, Punam Gaurav Sawarkar&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG Scholar, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University) Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor &amp;amp; Head, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Pharmacology, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Panchakarma, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pawan Banduji Itankar</style></author><author><style face="normal" font="default" size="100%">Gaurav Rajendra Sawarkar</style></author><author><style face="normal" font="default" size="100%">Punam Gaurav Sawarkar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmaceutical Development, Standardization, and Evaluation of an Ehretia Laevis Roxb. Tincture Ointment for Topical Wound Healing</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ehretia laevis; Tincture ointment; Wound healing; Accelerated stability; Topical drug delivery</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">233-239</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ehretia laevis&lt;/em&gt; Roxb. (Boraginaceae) is widely used in traditional Indian medicine, particularly by tribal communities, for the treatment of wounds and skin ailments. However, despite its ethnomedicinal importance, no standardized topical formulation has been developed to ensure consistent quality, safety, and efficacy. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to formulate and evaluate a standardized topical ointment incorporating&lt;em&gt; E. laevis&lt;/em&gt; hydroalcoholic tincture with detailed physicochemical characterization, microbial safety assessment, and stability profiling. &lt;strong&gt;Methods:&lt;/strong&gt; A hydroalcoholic tincture (70% ethanol) was prepared from shade-dried leaves of &lt;em&gt;E. laevis&lt;/em&gt; by maceration (yield 22.6% w/w). A 2% w/w ointment was formulated using a petroleum jelly base by the fusion method. The formulation was evaluated for organoleptic characteristics, physicochemical parameters (pH, viscosity, spreadability, loss on drying, iodine value, peroxide value), microbial contamination (total viable count and specific pathogens, detection limit 10 CFU/g), accelerated stability (40±2°C/75±5% RH for 3 months), and in vitro skin permeation using Franz diffusion cells with Strat-M® membranes (thickness 300±50 μm). &lt;strong&gt;Results: &lt;/strong&gt;The ointment exhibited a green color, characteristic herbal odor, smooth texture, and absence of phase separation. Physicochemical parameters were within acceptable limits (pH 4.9, viscosity 9.5 Poise, loss on drying 0.48%). No microbial contamination or pathogens were detected. Stability studies showed minimal variations, maintaining acceptable quality. In vitro permeation demonstrated biphasic release with an initial burst followed by sustained diffusion, fitting the Higuchi kinetic model (R² = 0.989). &lt;strong&gt;Conclusion:&lt;/strong&gt; The developed ointment is stable, microbiologically safe, and exhibits desirable release characteristics, providing a promising standardized phytopharmaceutical approach for wound management. Further in vivo studies are warranted.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">233</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pawan Banduji Itankar&lt;sup&gt;1&lt;/sup&gt;, Gaurav Rajendra Sawarkar&lt;sup&gt;2&lt;/sup&gt;, Punam Gaurav Sawarkar&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG Scholar, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University) Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor &amp;amp; Head, Department of Panchakarma, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;
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