<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sofia Wardhani</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of HBOT on SIRT-1 and SYNDECAN-1 as Therapeutic Targets for Endothelial Dysfunction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endothelial dysfunction</style></keyword><keyword><style  face="normal" font="default" size="100%">HBO2</style></keyword><keyword><style  face="normal" font="default" size="100%">Sirt-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Syndecan-1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1090-1095</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The effect of HBO2 alone on Sirt-1 and Syndecan-1 is unknown, even though both molecules are involved in preventing endothelial dysfunction. This study aims to determine the effect of HBO&lt;sub&gt;2&lt;/sub&gt; on Sirt-1 and Syndecan-1 as therapeutic targets for endothelial dysfunction. &lt;strong&gt;Method:&lt;/strong&gt; This study employed a true experimental post-test design. Twenty male Sprague Dawley rats aged 12-14 weeks were divided into two groups. Diving was carried out in an animal hyperbaric chamber with a dose of 2.4 ATA for 60 minutes. All data were collected 18 hours after diving. &lt;strong&gt;Results:&lt;/strong&gt; Our study revealed that the administration of HBO caused an increase in serum MDA and endothelial NF-kB levels (p = 0.007; p = 0.001, respectively) without an increase in any inflammatory markers, specifically IL-1 and VCAM-1 levels (p = 0.707; p = 0.168, respectively). HBO&lt;sub&gt;2 &lt;/sub&gt;decreased Syndecan-1, a marker of endothelial injury (p = 0.026), but did not affect endothelial eNOS and Sirt-1. &lt;strong&gt;Conclusion: &lt;/strong&gt;HBO&lt;sub&gt;2&lt;/sub&gt; did not cause endothelial injury and inflammation, but the dose used was not enough to increase Sirt-1 levels. Additional research is needed to determine a hormesis dose that can increase Sirt-1 levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1090</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sofia Wardhani&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;2*&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sofia Wardhani</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HBOT2 Preconditioning Prolonged Inflammation After Decompression Diving</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HBO2 preconditioning</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-1a</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Syndecan-1</style></keyword><keyword><style  face="normal" font="default" size="100%">VCAM-1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1192-1195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The mechanism involved in HBO&lt;sub&gt;2&lt;/sub&gt; preconditioning in preventing inflammation in diving is still unclear. Syndecan-1, which is an important part of glycocalyx, has never been studied for its involvement in HBO&lt;sub&gt;2&lt;/sub&gt; preconditioning to prevent inflammation in decompression diving. This study aims to determine how HBO&lt;sub&gt;2&lt;/sub&gt; preconditioning impacts inflammation through Syndecan-1, MDA, and IL-1a markers.&lt;strong&gt; Method:&lt;/strong&gt; This study is a true experimental post-test design. Forty male 12- to 14-year-old Sprague Dawley rats were divided into four groups. HBO&lt;sub&gt;2 &lt;/sub&gt;and decompression diving were carried out in an animal hyperbaric chamber. All data were collected 12 and 24 hours after the decompression diving.&lt;strong&gt; Result: &lt;/strong&gt;The incidence of decompression sickness was less frequent in the HBO&lt;sub&gt;2 &lt;/sub&gt;preconditioning treatment group as opposed to the control group (4 vs 9) but did not reach a significant level (p &amp;gt; 0.05). All parameters showed no difference between the control and treatment groups 12 hours after the dive (p &amp;gt; 0.05). Twenty-four hours after diving, the treatment group demonstrated substantially elevated IL-1a levels in comparison to the control group (p = 0.030), and the increase of IL-1a in the treatment group is significant (p = 0.001). Although MDA levels did not reach significant, the treatment group's increase in MDA levels 24 hours after diving was greater than that of the control group. Meanwhile, The treatment group had a smaller reduction in Syndecan-1 levels in comparison to the control group following diving 24 hours later. &lt;strong&gt;Conclusion:&lt;/strong&gt; HBO&lt;sub&gt;2&lt;/sub&gt; preconditioning prolongs the inflammation, as evidenced by increased levels of MDA, Syndecan-1, and IL-1a, even though it can prevent decompression sickness. Further research is needed to find the right time and dose of HBO&lt;sub&gt;2&lt;/sub&gt; preconditioning to shorten the inflammation time.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1192</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sofia Wardhani&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;2*&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Physiology and Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Gusti Agung Ayu Eka Putri Sunari</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Faradila Khoirun Nisa Hakim</style></author><author><style face="normal" font="default" size="100%">May Fanny Tanzilia</style></author><author><style face="normal" font="default" size="100%">Ida Parwati</style></author><author><style face="normal" font="default" size="100%">Rismawati Yaswir</style></author><author><style face="normal" font="default" size="100%">Budi Mulyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Positive NS1 Antigen in Non-Dengue Virus Infection Serum: Possible Reasons for the Discrepancy with DENV PCR Results</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dengue Virus Infection.</style></keyword><keyword><style  face="normal" font="default" size="100%">NS1Ag</style></keyword><keyword><style  face="normal" font="default" size="100%">RT-PCR DENV</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">923-926</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objective: &lt;/strong&gt;A specific examination is required to distinguish between DVI and viral, bacterial, and parasitic illnesses because their clinical manifestations are nearly identical. Leukopenia and lymphocytosis are examples of non-specific tests that might be used to get a diagnosis. Non-structural protein 1 (NS1) antigen, anti-DENV antibody, or DENV-specific nucleic acid detection are more specific assays. &lt;strong&gt;Methods:&lt;/strong&gt; Virus isolation or molecular analysis of the detection of DENV nucleic acid ribonucleic acid (RNA) using RT-PCR was used to make the conclusive diagnosis of DVI. The sensitivity of the DENV RT-PCR method ranges from 28.8 to 99%. NS1 antigen is used as an initial diagnostic option in primary health care because it has a high specificity value (100%). Researchers want to analyze the positivity in non-DVI samples that have been confirmed by real-time RT-PCR examination with semi-quantitative NS1 antigen examination. Patient population aged 1-65 years with acute fever &amp;lt;5 days. A total of 130 samples of non-DVI confirmed patients by RT-PCR were examined for NS1Antigen ELISA. &lt;strong&gt;Results: &lt;/strong&gt;With a proportion of 3.08% of the total sample, the results showed that 4 NS1Antigen ELISA samples were positive. A negative DENV RT-PCR result could indicate either a true negative or a false negative. &lt;strong&gt;Conclusion: &lt;/strong&gt;The type of PCR technology, the primer used, the existence or absence of a DENV mutation, the DENV serotype, and the presence of mismatched nucleotides can all affect variations in DENV PCR sensitivity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">923</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;I Gusti Agung Ayu Eka Putri Sunari&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;1*&lt;/sup&gt;, Faradila Khoirun Nisa Hakim&lt;sup&gt;2&lt;/sup&gt;, May Fanny Tanzilia&lt;sup&gt;3&lt;/sup&gt;, Ida Parwati&lt;sup&gt;4&lt;/sup&gt;, Rismawati Yaswir&lt;sup&gt;5&lt;/sup&gt;, Budi Mulyono&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Airlangga – Dr. Soetomo Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Ciputra, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, IINDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing,&amp;nbsp;Universitas Gadjah Mada - Dr. Sardjito General Hospital, Yogyakarta, INDONESIA&lt;/p&gt;
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