<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gaurav Sharma</style></author><author><style face="normal" font="default" size="100%">Sunil Kumar</style></author><author><style face="normal" font="default" size="100%">Megha Sharma</style></author><author><style face="normal" font="default" size="100%">Navneet Upadhyay</style></author><author><style face="normal" font="default" size="100%">Sunil Kumar</style></author><author><style face="normal" font="default" size="100%">Zabeer Ahmed</style></author><author><style face="normal" font="default" size="100%">Neeraj Mahindroo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Diabetic, Anti-Oxidant and Anti-Adipogenic Potential of Quercetin Rich Ethyl Acetate Fraction of Prunus persica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-adipogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Prunus persica</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/509</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">463-469</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus is enfeebling threatening diseases with continuously increasing rates of incidence and mortality and it may rise tremendously by 2025. &lt;strong&gt;Objective:&lt;/strong&gt; Quercetin rich ethyl acetate fraction (PP-EtOA) of leaves of &lt;em&gt;Prunus persica&lt;/em&gt; was evaluated for antidiabetic, anti-oxidant and anti-adipogenic activities. Material and Methods: Streptozotocin (STZ)-induced diabetic rat model, oral glucose tolerance test (OGTT) and normalglycemic rat models were investigated at the doseof 100 and 200 mg/kg,&lt;em&gt;p.o&lt;/em&gt;. of PP-EtOA. &lt;strong&gt;Results:&lt;/strong&gt; At 200 mg/kg, significant anti-hyperglycaemic activity(&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) was observed in all the rat models. In STZ induced diabetic rat model, improvement in body weight and lipid profile was also observed.DPPH (2,2&amp;rsquo;-diphenyl-1-picrylhydrazyl) free radical scavenging method showed dose dependent scavenging. Preadipocyte differentiation assay (3T3-L1) showed significant inhibition of differentiation. HPLC fingerprinting analysis of fraction was also performed. &lt;strong&gt;Conclusion:&lt;/strong&gt; PP-EtOA possesses potent free radical scavenging property. Its antihyperglycemic and antiadipogenic activities may be due to quercetin (flavonoid) and may prove to be effective in the treatment of diabetes mellitus and diabetes driven dyslipidemic conditions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">463</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gaurav Sharma&lt;sup&gt;1*&lt;/sup&gt;, Sunil Kumar&lt;sup&gt;1&lt;/sup&gt;, Megha Sharma&lt;sup&gt;1&lt;/sup&gt;,&amp;nbsp;Navneet Upadhyay&lt;sup&gt;1&lt;/sup&gt;, Sunil Kumar&lt;sup&gt;2&lt;/sup&gt;, Zabeer Ahmed&lt;sup&gt;3&lt;/sup&gt;, Neeraj Mahindroo&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Parasitology, Post Graduate Institute of Medical Education and Research, Chandigarh, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Pharmacology, Indian Institute of Integrative Medicine (CSIR), Jammu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aditi Gupta</style></author><author><style face="normal" font="default" size="100%">Sunil Kumar</style></author><author><style face="normal" font="default" size="100%">Neeraj Mahindroo</style></author><author><style face="normal" font="default" size="100%">Reena Vohra Saini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Fraction from Datura stramonium Linn. Promotes Human immune Cells Mediated Cytotoxicity towards Lung and Breast Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Datura stramonium.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulation</style></keyword><keyword><style  face="normal" font="default" size="100%">PBMC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">435-439</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of the present study was to evaluate immune modulatory effect of fractions of &lt;em&gt;D. stramonium&lt;/em&gt; L. leaves on human peripheral blood mononuclear cells (PBMC) followed by assessment of cytotoxic abilities of immunomodulated PBMC toward cancer cells. &lt;strong&gt;Material and methods: &lt;/strong&gt;Bioassay (PBMC proliferation) guided fractionation of methanolic leaf extract of &lt;em&gt;D. stramonium&lt;/em&gt; was performed to get active fraction and LC-MS was performed to identify the phytocompounds present in the bioactive fraction. The immunomodulatory potential of&lt;em&gt; D.&lt;/em&gt; &lt;em&gt;stramonium&lt;/em&gt; active fraction was assessed by i) MTT microcytotoxicity assay using A549 (lung carcinomas) and MCF-7 (breast cancer) cell lines and ii) analyzing the production of IL-2 and IFN-&amp;gamma; by human PBMC in the presence of active fraction. &lt;strong&gt;Results:&lt;/strong&gt; Chromatographic fractionation guided by PBMC proliferation assay of &lt;em&gt;D. stramonium&lt;/em&gt; extract resulted in bioactive fraction (fraction-10) exhibiting significant immunostimulatory activity [EC&lt;sub&gt;50&lt;/sub&gt;=19.1&amp;plusmn;1.5 (&amp;mu;g/ml)] on human blood lymphocytes. Fraction-10 pretreated PBMC displayed enhanced cytotoxicity towards A549 and MCF-7 (59%&amp;plusmn;2.1% and 62%&amp;plusmn;2.3% at 1:20 effector:target ratio respectively). Moreover, fraction-10 also enhanced the secretion of IL-2 (8 fold) and IFN-&amp;gamma; (10 fold) by human PBMC. The preliminary phytochemical analysis of fraction-10 from&lt;em&gt; D. stramonium&lt;/em&gt; showed the presence of terpenoids and steroids. LC-MS analysis depicted presence of four major phytoconstituents in fraction-10 as daturaolone, daturadiol, stigmasterol and sitosterol with corresponding mass spectrum (m/z) of 440, 442, 412 and 414 respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present report concluded that active fraction-10 of&lt;em&gt; D. stramonium&lt;/em&gt; possesses potential immunostimulators that are capable of enhancing anticancer responses of human blood lymphocytes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aditi Gupta&lt;sup&gt;1&lt;/sup&gt;, Sunil Kumar&lt;sup&gt;2&lt;/sup&gt;, Neeraj Mahindroo&lt;sup&gt;2&lt;/sup&gt;, Reena Vohra Saini&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Animal Biotechnology Laboratory, Faculty of Applied Sciences and Biotechnology, Shoolini University, Himachal Pradesh, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology Laboratory, Faculty of Pharmaceutical Sciences, Shoolini University, Himachal Pradesh, INDIA.&lt;/p&gt;
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