<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasetyo Sarwono Putro</style></author><author><style face="normal" font="default" size="100%">Dono Indarto</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Widyastuti Soewondo</style></author><author><style face="normal" font="default" size="100%">Sulistyani Kusumaningrum</style></author><author><style face="normal" font="default" size="100%">Khim Yatul Nguzum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effects of Leaves Extract of Toddalia aculeata on Body Weight, Body Mass Index, Body Fat Content and Resistive Index in Male Rats with High-Fat Diet</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Body Fat Content</style></keyword><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Resistive Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Toddalia Aculeata Extract.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">771-777</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Dictamine&lt;/em&gt; is found in the Toddalia aculeata plant and is able to interact with &lt;em&gt;Flavin- Containing Monooxygenase-3 &lt;/em&gt;(FMO3) in silico, which mediates endogenous atherosclerosis formation. Therefore, this study aimed to investigate the effects of&lt;em&gt; T. aculeata&lt;/em&gt; extract (TAE) administration on Body Weight (BW), Body Mass Index (BMI), Body Fat Content (BFC), and Resistive Index (RI) in rats with a high-fat diet. &lt;strong&gt;Methods: &lt;/strong&gt;Forty male Sprague-Dawley rats were randomly divided into the negative control (NC), positive control (PC) + 2.98 μg/kg BW &lt;em&gt;dictamine&lt;/em&gt; and treatment (TAE1-3) + 200, 400, and 800 mg/ kg BW TAE respectively. All rats were given a high-fat diet (HFD) for 28 days. The data were analyzed statistically using one-way ANOVA, repeated-measured ANOVA, and Friedman’s tests with p&amp;lt;0.05. &lt;strong&gt;Results:&lt;/strong&gt; The average of rats’ BW in TAE2 (270±13.78 g) and TAE3 (276.62±40.31 g) was lower than that of the NC (304.12± 4.16 g) but only the TAE2 group was significantly different (p=0.032). Rats in the TAE 1-3 groups had the average BMI (26.03±5.61; 21.84±0.81; 20.78±2.17 g/cm&lt;sup&gt;3&lt;/sup&gt;) significantly lower than the NC (29.61±2.28 g/cm&lt;sup&gt;3&lt;/sup&gt;) and the PC (28.67±1.68 g/cm&lt;sup&gt;3&lt;/sup&gt;) for TAE2 and 3. The same pattern was also observed in BFC. All treatment groups had significantly lower RI compared to the NC group (0.62±0.07 cm).&lt;strong&gt; Conclusion&lt;/strong&gt;: Administration of 400 and 800 mg/kg BW TAE for 28 days decreases BW, BMI, BFC, and RI in rats with a high-fat diet. &lt;em&gt;Dictamine&lt;/em&gt; in the ethanol extract of &lt;em&gt;T. aculeata&lt;/em&gt; leaves might contribute to the reduction of RI in rats with a high-fat diet.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">771</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasetyo Sarwono Putro&lt;sup&gt;1,2&lt;/sup&gt;, Dono Indarto&lt;sup&gt;1,3,4,*&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;1,5&lt;/sup&gt;, Widyastuti Soewondo&lt;sup&gt;2&lt;/sup&gt;, Sulistyani Kusumaningrum&lt;sup&gt;1,2&lt;/sup&gt;, Khim Yatul Nguzum&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctorate Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Radiology, Dr. Moewardi General Hospital/Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Biomedical Laboratory, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;
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