<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yanu Andhiarto</style></author><author><style face="normal" font="default" size="100%">Faisal Akhmal Muslikh</style></author><author><style face="normal" font="default" size="100%">Suciati</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Metabolite Profiling of Different Parts of Syzygium cumini var. album and Physicochemical Testing of its Identical Compounds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Syzygium cumini var. album; Chlordecone reductase inhibitor; biological activity; physicochemistry; toxicity analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1272-1280</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is the second most biodiverse country in the world and is classified as a megadiverse country. &lt;em&gt;Syzygium cumini&lt;/em&gt; is known to have various pharmacological activities, such as anti-inflammatory, antioxidant, antibacterial, antifungal, antidiarrheal, and others. This study aims to explore the metabolite profile of 70% ethanolic extract from the leaves and bark of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album and analyze the physicochemical properties of its identical compounds. Phytochemical screening was conducted using commonly used methods, and metabolite profiling was carried out using UPLC-QToF-MS/MS. Pharmacological bioactivity and physicochemical properties of the identified compounds were analyzed using web tools such as Way2Drug, SwissADME, and ProTox II. The results showed that the ethanolic extract of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album leaves contain 33 compounds, while the bark extract contains 26 compounds. Morin and alnusiin were identified in both samples. Based on PASS activity testing, morin exhibited Chlordecone reductase inhibitor activity and has potential for further development due to its favorable physicochemical properties and safety profile based on toxicity tests. This study demonstrates that the leaf and bark extracts of &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album contain morin and alnusiin, with morin showing potential as an effective and safe therapeutic agent as a Chlordecone reductase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1272</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yanu Andhiarto&lt;sup&gt;1,2&lt;/sup&gt;, Faisal Akhmal Muslikh&lt;sup&gt;2&lt;/sup&gt;, Suciati&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yanu Andhiarto</style></author><author><style face="normal" font="default" size="100%">Suciati</style></author><author><style face="normal" font="default" size="100%">Ersanda Nurma Praditapuspa</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Analysis and ADMET Prediction of Flavonoid Compounds from Syzigium cumini var. album on α-Glucosidase Receptor for Searching Anti-Diabetic Drug Candidates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid.</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">PASS</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacokinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">736-743</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;One of the causes of death is diabetes. Anti-diabetic drugs currently available do not work optimally because some have been reported to have side effect and resistance. Objective: This study aimed to flavonoid compounds from &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album with the greatest anti-diabetic activity and lower toxicity than acarbose. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; This research is an&lt;em&gt; in silico&lt;/em&gt; study of nine flavonoid compounds from&lt;em&gt; Syzygium cumin&lt;/em&gt;i var. album, starting with PASS online was used to predict the activity spectrum of substances, drug-likeness prediction using DruLiTo, ADMET prediction (absorption, distribution, metabolism, excretion, and toxicity) using pkCSM online. Molecular docking was carried out by the AutoDock 4.2.6 program on α-glucosidase targeting. Visualization is done with the Discovery Studio Visualizer software.&lt;strong&gt; Results:&lt;/strong&gt; From the data obtained, D-(+)-Catechin has a high affinity for α-glucosidase with a free energy of binding (ΔG) -5.94 kcal/mol and an inhibition constant (Ki) of 44270 nm.&lt;strong&gt; Conclusion:&lt;/strong&gt; Based on the results of the study, it can be concluded that the flavonoid compounds from &lt;em&gt;Syzygium cumini&lt;/em&gt; var. album has the potential as a promising anti-diabetic drug candidate, where the best candidate is D- (+)-Catechin. However, further studies of flavonoid compounds from&lt;em&gt; Syzygium cumini&lt;/em&gt; var. album are needed.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">736</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yanu Andhiarto&lt;sup&gt;1&lt;/sup&gt;, Suciati&lt;sup&gt;2&lt;/sup&gt;, Ersanda Nurma Praditapuspa&lt;sup&gt;3&lt;/sup&gt;, Sukardiman&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></auth-address></record></records></xml>