<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marwan Mohamed Alshawush</style></author><author><style face="normal" font="default" size="100%">Hussein Ali Burshed</style></author><author><style face="normal" font="default" size="100%">Abdullah Jalal Alasoom</style></author><author><style face="normal" font="default" size="100%">Abdullah Abdulhamid Altaweel</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profiling, Antioxidant and Lipoxygenase Enzyme Inhibition Activities of Wild Edible Truffle (Terfezia boudieri) from Northern Borders of Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoxygenase inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Terfezia boudieri</style></keyword><keyword><style  face="normal" font="default" size="100%">Truffle</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">319-326</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Truffles are natural food product very famous for its health benefits for being significant biosource of essential fatty acids, proteins and other antioxidant and phenolic compounds. The current study was conducted to evaluate the phytochemicals, antioxidant and lipoxygenase inhibition activities of &lt;em&gt;Terfezia boudieri of &lt;/em&gt;Saudi origin. Various phytochemicals were screened applying standard procedures. The total methanol extract (TME) of the truffle was subjected to several chromatographic procedures. The antioxidant activity was evaluated by DPPH antioxidant procedure, comparing results with trolox as standard. Results demonstrated that &lt;em&gt;Terfezia boudieri &lt;/em&gt;chemically characterized by the availability of various constituents such as flavonoids, steroids, saponins, tannins and carbohydrates at different levels. Phytochemical investigation led to the isolation of β-sitosterol and gallic acid that were identified using 1H, &lt;sup&gt;13&lt;/sup&gt;C, DEPT, COSY, HMQC and HMBC NMR spectroscopic data. Results demonstrated high antioxidant activity with IC&lt;sub&gt;50&lt;/sub&gt;: 50.4 μg/ml and 31.4 μg/ml for TME and gallic acid, respectively. TME and gallic acid exhibited lipoxygenase inhibitory activity with IC&lt;sub&gt;50&lt;/sub&gt; values 4.59 and 0.53 μg/ml for TME and gallic acid, respectively. The higher lipoxygenase inhibitory activity was presumably correlated to the high antioxidant activity. In conclusion, current investigation confirms the folklore use of &lt;em&gt;Terfezia boudieri&lt;/em&gt; as&lt;em&gt; &lt;/em&gt;antinflammatory food. Hence, the studied &lt;em&gt;Terfezia boudieri &lt;/em&gt;may have a great potential as antioxidant and antinflammatory functional food and nutraceuticals products for pharmaceutical applications.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">10</style></accession-num><section><style face="normal" font="default" size="100%">319</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marwan Mohamed Alshawush*, Hussein Ali Burshed, Abdullah Jalal Alasoom, Abdullah Abdulhamid Altaweel, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shahad Mohammed Nasser Alqahtani</style></author><author><style face="normal" font="default" size="100%">Dalya Ramzi Alsuliman</style></author><author><style face="normal" font="default" size="100%">Abdullah Jalal Alasoom</style></author><author><style face="normal" font="default" size="100%">Hussein Ali Burshed</style></author><author><style face="normal" font="default" size="100%">Marwan Mohamed Alshawush</style></author><author><style face="normal" font="default" size="100%">Abdullah Abdulhamid Altaweel</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cichorioside a biocoumarin modulates lipid and glucose storage on 3T3-L1 cell lines: In vitro and in silico approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3T3-L1cell lines</style></keyword><keyword><style  face="normal" font="default" size="100%">Cichorioside</style></keyword><keyword><style  face="normal" font="default" size="100%">Oil red O staining</style></keyword><keyword><style  face="normal" font="default" size="100%">PPARγ</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">933-937</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Natural coumarins are reputed to demonstrate several biological effects to improve adverse health conditions including; obesity. This study was conducted to explore the potential&lt;em&gt; in vitro&lt;/em&gt; lipid and glucose modulatory activity of cichorioside on 3T3-L1 cell lines .&lt;strong&gt; Methods: &lt;/strong&gt;The 3T3-L1 cell lines were cultured and cell viability was assessed. Glucose content in medium of cultured cells was measured. Differentiation of 3T3-L1 cells from pre-adipocytes to adipocytes was evaluated upon addition of cichorioside. Expression of mRNA of the peroxisome proliferator-activated receptor gamma (PPARγ) was estimated. &lt;strong&gt;Results: &lt;/strong&gt;Survival of around 90% of cultured cells was observed at 10μM cichorioside. Cichorioside inhibited glucose uptake from the medium by the 3T3-L1 cell lines. Cichorioside considerably inhibited pre-adipocyte differentiation and the lipid content in intercellular storage. Cichorioside demonstrated an upregulation of the mRNA expression of PPARγ. Moreover, the docking studies supported the results &lt;em&gt;via &lt;/em&gt;the deep interaction of cichorioside with amino acids residue of PPAR-γ. Taken together, these findings are the first report on &lt;em&gt;in vitro&lt;/em&gt; evaluation of cichorioside to modulate the lipid storage and glucose uptake of cultured 3T3-L1 cell lines&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">933</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shahad Mohammed Nasser Alqahtani*, Dalya Ramzi Alsuliman, Abdullah Jalal Alasoom, Hussein Ali Burshed, Marwan Mohamed Alshawush, Abdullah Abdulhamid Altaweel, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdullah Abdulhamid Altaweel</style></author><author><style face="normal" font="default" size="100%">Abdullah Jalal Alasoom</style></author><author><style face="normal" font="default" size="100%">Hussein Ali Burshed</style></author><author><style face="normal" font="default" size="100%">Marwan Mohamed Alshawush</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Insight into Screening of Secondary Metabolites, Phenolic and Flavonoid Contents and Antioxidant Activity of Raphanus sativus L. Cultivated in Eastern Province of Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Folin-Ciocalteau</style></keyword><keyword><style  face="normal" font="default" size="100%">Raphanus sativus</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid.</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">313-318</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants and vegetables are promising source of antioxidant products. The purpose of this study is to evaluate the phytochemicals and antioxidant activity of leaves and roots of &lt;em&gt;Raphanus sativus &lt;/em&gt;of Saudi origin. Various phytochemicals were screened in n-hexane, chloroform, ethyl acetate and aqueous fractions of leaves and roots of &lt;em&gt;Raphanus sativus &lt;/em&gt;using standard protocols and IR screening method. Total phenolic (TPC) and flavonoid (TFC) contents were assessed by Folin-Ciocalteau and aluminium chloride methods respectively. The antioxidant activity was evaluated by DPPH antioxidant protocol, using trolox as standard. Results demonstrated that &lt;em&gt;Raphanus sativus&lt;/em&gt; chemically characterized by the availability of various constituents such as flavonoids, steroids, saponins, tannins and carbohydrates at different levels in fractions of leaves and roots of&lt;em&gt; Raphanus sativus&lt;/em&gt; and the absence of cardiac glycosides, anthraquinones and alkaloids which was further confirmed using FTIR analysis. TPC was ranged from (8.92±1.01) and (211.80±1.57) mg GAE/g extract and TFC was ranged from (0.036±0.03) and (11.57±0.60) mg QE/g extract for leaves and roots extracts respectively. Due to the high phenolic and flavonoid content in aqueous and ethyl acetate fractions of leaves and roots extracts , results demonstrated high antioxidant activity with IC&lt;sub&gt;50&lt;/sub&gt;: (56.3±1.3) and (69.7±1.8) for aqueous fractions and (47.2±1.5) and (58.7±0.7) for ethyl acetate fractions of leaves and roots extracts respectively Study revealed that ethyl acetate and aqueous fractions of leaves and roots of&lt;em&gt; Raphanus sativus &lt;/em&gt;could develop a potential natural antioxidant herbal remedy. The study recommends future investigation to isolate and identify the bioactive secondary metabolites in &lt;em&gt;Raphanus sativus.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">09</style></accession-num><section><style face="normal" font="default" size="100%">313</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdullah Abdulhamid Altaweel*, Abdullah Jalal Alasoom, Hussein Ali Burshed, Marwan Mohamed Alshawush, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammed Wasel Matar</style></author><author><style face="normal" font="default" size="100%">Shahad Mohammed Nasser Alqahtani</style></author><author><style face="normal" font="default" size="100%">Duaa Adnan Alghafli</style></author><author><style face="normal" font="default" size="100%">Abdullah Abdulhamid Altaweel</style></author><author><style face="normal" font="default" size="100%">Abdullah Jalal Alasoom</style></author><author><style face="normal" font="default" size="100%">Hussein Ali Burshed</style></author><author><style face="normal" font="default" size="100%">Marwan Mohamed Alshawush</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Approach Including Total Phenolic and Flavonoid Contents and Evaluation of in vitro ABTS Antioxidant Capacity and Lipoxygenase Inhibition of Anisosciadium lanatum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">Anisosciadium lanatum</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">928-932</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Anisosciadium lanatum&lt;/em&gt; Boiss is commonly known in Bedouins as besbas. Traditional, it is palatable plant and used in medicine of livestock to treat skin conditions . The main objective of current approach was to screen the presence of different kind of metabolites applying standard procedures followed by assessment of total phenolic (TPC) and flavonoids (TFC) contents. In addition, the&lt;em&gt; in vitro &lt;/em&gt;ABTS antioxidant and lipoxygenase activities were evaluated. Different organs (leaves, stems and flowers) of &lt;em&gt;Anisosciadium lanatum&lt;/em&gt; were extracted using 70% methanol to yield total methanol extracts of leaves (TML), stems (TMS) and flowers (TMF). Results demonstrated that TML, TMS and TMF are characterized by the content of different constituents such as flavonoids, phenolics/tannins, steroids, saponins, and carbohydrates at different levels. Ethyl acetate (EA) and butanol (BT) fractions of TML and TMS demonstrated the highest percentage of TPC and TFC. The results demonstrated the competence of EA and BT as free radical scavenger fractions compared to other fractions and its opportunity to contain bioactive antioxidant metabolites . TML, TMS and TMF exhibited Lipoxygenase inhibitory activity with IC50 values of 4.88, 5.40 and 6.05 μg/mL, respectively when compared to that of the positive control baicalein (IC50: 0.27 μg /mL). In conclusion, present investigation highlighted the potential of &lt;em&gt;Anisosciadium lanatum&lt;/em&gt; to be promising candidate with activity against wide range of inflammatory-related diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">928</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammed Wasel Matar*, Shahad Mohammed Nasser Alqahtani, Duaa Adnan Alghafli, Abdullah Abdulhamid Altaweel, Abdullah Jalal Alasoom, Hussein Ali Burshed, Marwan Mohamed Alshawush, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dalya Ramzi Alsuliman</style></author><author><style face="normal" font="default" size="100%">Zainab Mohammed Al Sultan</style></author><author><style face="normal" font="default" size="100%">Maryam Khalil Almajhad</style></author><author><style face="normal" font="default" size="100%">Nour Kamal Alhajri</style></author><author><style face="normal" font="default" size="100%">Abdullah Abdulhamid Altaweel</style></author><author><style face="normal" font="default" size="100%">Abdullah Jalal Alasoom</style></author><author><style face="normal" font="default" size="100%">Hany Ezzat Khalil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Profound Assessment of Phytochemical, Botanical and Antioxidant Characteristics Including Determination of Total Phenolic and Flavonoid Contents of Stem Bark of Cordia obliqua L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS.</style></keyword><keyword><style  face="normal" font="default" size="100%">Boraginaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia obliqua</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Folin-Ciocalteau</style></keyword><keyword><style  face="normal" font="default" size="100%">Total phenolic and flavonoid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">753-758</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Cordia obliqua i&lt;/em&gt;s known as Bumber. Its fruits and leaves are popularly used because of antioxidant and anti-diabetic activities. The purpose of this study is to evaluate the phytochemicals and antioxidant activity as well as botanical features of stem bark of &lt;em&gt;Cordia obliqua&lt;/em&gt;. Chemical components were preliminary screened in various fractions based on the polarities including; n-hexane, chloroform, ethyl acetate, butanol and aqueous fractions of using standard procedures. Total phenolic (TPC) and flavonoid (TFC) contents were assessed by Folin-Ciocalteau and aluminium chloride methods respectively. The antioxidant activity was evaluated by ABTS antioxidant procedure, using ascorbic acid as standard. Results confirmed that stem bark of&lt;em&gt; Cordia obliqua&lt;/em&gt; chemically is characterized by the presences of flavonoids, alkaloids, steroids, saponins, tannins and carbohydrates at different levels in various fractions and the absence of cardiac glycosides and anthraquinones. Microscopically, the plant is characterized by presence of big Ca oxalate clusters, various types of xylem vessels and big amount of cork cells. TPC was ranged from 13.6±1.4 and 220.5±3.4 mg GAE/g dry plant extract and TFC was ranged from 0.029±0.12and 15.46±0.33 mg QE/g dry plant extract. Due to the high phenolic and flavonoid content in butanol and ethyl acetate fractions; results of antioxidant using ABTS assay showed high antioxidant activity with IC&lt;sub&gt;5&lt;/sub&gt;0 valued 11.84±1.2 μg/ ml for butanol fraction and 14.81±1.1 μg/ml for ethyl acetate fraction. Taken together, the research work demonstrated the potential natural antioxidant value of the waste product stem bark of &lt;em&gt;Cordia obliqua.&lt;/em&gt; The study endorses forthcoming work to isolate and identify the chemical constituents in stem bark of Cordia obliqua.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">753</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dalya Ramzi Alsuliman*, Zainab Mohammed Al Sultan, Maryam Khalil Almajhad, Nour Kamal Alhajri, Abdullah Abdulhamid Altaweel, Abdullah Jalal Alasoom, Hany Ezzat Khalil*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, SAUDI ARABIA.&lt;/p&gt;
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