<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Djatiwidodo Edi Pratiknya</style></author><author><style face="normal" font="default" size="100%">Risma</style></author><author><style face="normal" font="default" size="100%">Ariyo Sakso Bintoro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Hyperbaric Oxygen Therapy (HBOT) on the  Histopathological Lung Cells of Male White Wistar Rats Which are  Intoxicated with Methanol</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histopathological Lung Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperbaric Oxygen Therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1202-1206</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Methanol is a liquid that has the characteristics of being light, very easy to evaporate, colorless, flammable, toxic, and has a very distinctive odor like ethanol but lighter. The World Health Organization (WHO) globally states that 320,000 people die every year due to methanol poisoning in the age range of around 15 years to 29 years. Usually, symptoms of poisoning caused by methanol appear within 30 minutes to 2 hours. Based on the phenomenon that occurred, the author wanted to find out more about the effect of HBOT administration on the histopathological appearance of lung cells in mice intoxicated with methanol. This study used 30 male white wistar rat lung samples aged 2 to 3 months weighing around 150 grams to 250 grams, divided into three groups, namely the control group, treatment group I, and treatment group II. The control group was not given methanol treatment and hyperbaric oxygen therapy (HBOT). Treatment group I was given methanol for 14 days without hyperbaric oxygen therapy. Meanwhile, the treatment group was given methanol for 14 days and then given hyperbaric therapy for 10 days. The results show p&amp;lt;0.0006, which means the data is significant and there are differences between groups. The results of this study can be concluded that administering hyperbaric oxygen therapy to rats intoxicated with methanol had a statistically significant improvement effect on the alveolar membrane, alveolar lumen, and connections between the alveoli.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1202</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Djatiwidodo Edi Pratiknya&lt;sup&gt;1,&lt;/sup&gt;*, Risma&lt;sup&gt;2&lt;/sup&gt; , Ariyo Sakso Bintoro&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Marine Health, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Urology Surgery, Naval Central Hospital Dr. Ramelan Surabaya, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alan Dharmasaputra</style></author><author><style face="normal" font="default" size="100%">Risma</style></author><author><style face="normal" font="default" size="100%">Annisa Ullya Rasyida</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azasterol Inhibition and Pharmacokinetic Effects on Thymidylate Synthase-Dihydrofolate Reductase from T. gondii: In Silico Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azasterol</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxoplasmosis</style></keyword><keyword><style  face="normal" font="default" size="100%">TS-DHFR.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">571-575</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Toxoplasmosis is a disease that causes health problems and can be found worldwide with a percentage of more than 60%, especially in developing countries such as Indonesia. Pyrimethamine-resistant strains of &lt;em&gt;T. gondii &lt;/em&gt;have been found, and it may contribute to reducing therapeutic failure in the future. Azasterol is a synthetic analog of solacongestidine, which can potentially be used as a new anti-toxoplasma drug. Resistance to the anti-toxoplasma drug, Pyrimethamine, makes Azasterol a very profitable discovery as a new anti-toxoplasma drug. This study aimed to determine the inhibitory and pharmacokinetic effects of Azasterol compounds on the development of &lt;em&gt;T. gondii &lt;/em&gt;based on &lt;em&gt;in silico&lt;/em&gt; studies. This oneshot experimental study analyzed the predicted inhibitory effect of Azasterol on Thymidylate synthasedihydrofolate reductase (TS-DHFR) from&lt;em&gt; T. gondii&lt;/em&gt; to observe the pharmacokinetic prediction and toxicity test of the Azasterol compound. Besides, this one-shot experimental study utilized the&lt;em&gt; in silico &lt;/em&gt;method. According to the results of molecular docking, Azasterol had an interaction with the TS-DHFR protein in the same binding area as the Pyrimethamine – TS-DHFR and Sulfadiazine – TS-DHFR complexes. Azasterol binding energy was higher than that of Pyrimethamine and Sulfadiazine. Azasterol had a good pharmacokinetic effect and had minimal toxic effects on the body.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">13</style></accession-num><section><style face="normal" font="default" size="100%">571</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Alan Dharmasaputra, Risma*, Annisa Ullya Rasyida&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;
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