<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán-Rodríguez</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro- Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant, Anxiolytic, and Antioxidant Properties of Piper Aduncum Essential Oil from Northern Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidepressant</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Anxiolytic</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper aduncum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1252-1258</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This investigation aimed to evaluate the antidepressant, anxiolytic, and antioxidant effects of &lt;em&gt;Piper aduncum&lt;/em&gt; essential oil from northern Peru. The essential oils were obtained through hydro-distillation using a modified Clevenger-type apparatus. The chromatography-mass spectrometry (GC-MS) was used to assess the chemical composition. Behavioral assays in mice were used to evaluate the antidepressant and anxiolytic effects. In addition, the antioxidant capacity was performed through DPPH, ABTS, and FRAP assays. The GC-MS analysis revealed that linalool (29.16%), bicyclogermacrene (13.32%), nerolidol (12.38%), and β-caryophyllene (10.76%) were the principal components. The results demonstrated significant antidepressant and anxiolytic effects comparable to fluoxetine and diazepam, with statistical differences between all groups (p&amp;lt;0.005). The IC50 values for the DPPH, ABTS, and FRAP assays were 5.9±0.08, 0.20±0.06, and 109.5±1.3, respectively. Consequently, &lt;em&gt;Piper aduncum&lt;/em&gt; essential oil exhibits antidepressant and anxiolytic-like effects and modest antioxidant properties compared to the controls.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1*&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Natalia Mavila Guzmán-Rodríguez&lt;sup&gt;1,3&lt;/sup&gt;, Elda Maritza Rodrigo-Villanueva&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Grupo de investigación en Salud Mental y Medicina Integrativa, Escuela de Medicina, Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Grupo de investigación de Productos Naturales y Sustancias Bioactivas. Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología, Universidad César Vallejo, Trujillo, PERÚ&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author><author><style face="normal" font="default" size="100%">Bertha Mirella Alfaro-Ttito</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anticancer and Neuroprotective Effects of the Triterpene Glycosides From Sea Cucumber Holothuria imitans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Holothuria imitans</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective.</style></keyword><keyword><style  face="normal" font="default" size="100%">Triterpene glycosides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">119-127</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sea cucumbers has gained notoriety because possess a wide range of biological and pharmacological activities. In this sense, the aim of this work was to evaluate the anticancer and neuroprotective effects of the triterpene glycosides from sea cucumber &lt;em&gt;Holothuria imitans&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;Triterpene glycosides were separated and purified by Reversed-phase high-performance liquid chromatography (RP-HPLC). Their structures were deduced by spectral analysis and chemical evidence. Cytotoxic activity was evaluated using normal African green monkey kidney epithelial cell line (VERO) and three cancer cell lines: cancer gastric (MKN-28), breast adenocarcinoma (MCF-7) and lung carcinoma (A-549). Besides, the neuroprotective effect was studied using the Cath.a-differentiated (CAD) cell line and human glial (Oligodendrocytic) hybrid cell line (MO3.13). &lt;strong&gt;Results: &lt;/strong&gt;Two triterpene glycosides (Fuscocineroside C and Scabraside D) were isolated, which showed low cytotoxic activity against VERO cell line, and high cytotoxic activity against lines MKN-28, MCF-7 and A-549 cells, with IC&lt;sub&gt;50 &lt;/sub&gt;between the ranges of 0.92 μmol/L to 2.61 μmol/L. The isolated triterpene glycosides showed the ability to regain mitochondrial viability in CAD and MO3.13 cells treated with neurotoxin (C2-ceramide) with statistically significant results (p&amp;lt;0.05).&lt;strong&gt; Conclusion: &lt;/strong&gt;The triterpene glycosides Fuscocineroside C and Scabraside D isolated from sea cucumber Holothuria imitans show anticancer and neuroprotective potential and may be considered promising active principles for anticancer and neuroprotective drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marilú Roxana Soto-Vásquez&lt;sup&gt;1,*&lt;/sup&gt;, Paul Alan Arkin Alvarado- García&lt;sup&gt;2&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;1&lt;/sup&gt;, Elda Maritza Rodrigo- Villanueva&lt;sup&gt;1&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;1&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;3&lt;/sup&gt;, Bertha Mirella Alfaro-Ttito&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Escuela de Posgrado de la Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author><author><style face="normal" font="default" size="100%">Taniht Lisseth Cubas-Romero</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Rosmarinus Officinalis Essential Oil On Anxiety, Depression, And Sleep Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinus officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">343-349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The objective of this investigation was to evaluate the effect of &lt;em&gt;Rosmarinus officinalis &lt;/em&gt;essential oil on anxiety, depression, and sleep quality. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and the chemical composition was performed by Gas chromatography with flame ionization detection (GC-FID) and Gas chromatography mass spectrometry (GC–MS). Furthermore, a quasi-experimental study was conducted, where 81 participants were divided into two groups, comprising a waiting list control group and an experimental group treated with essential oils. Anxiety and depression indexes were evaluated using the Zung Self-Rating Anxiety Scale (SAS) and the Zung Self-Rating Depression Scale (SDS), and sleep quality was measured with the Pittsburgh Sleep Quality Inventory (PSQI). &lt;strong&gt;Results:&lt;/strong&gt; Chemical analysis showed that 1,8 cineole (37.6%), α-pinene (19.9%), and linalool (15.8%) were the main components. Anxiety, depression, and sleep quality scores showed a decrease in the post-test study phase compared to the pre-test in the experimental group (p&amp;lt;0.05). A large size effect was found in the case of anxiety (d = 1.491; g= 1.490) with 1-β=0.996, while medium size effects were observed for depression (d = 0.581; g= 0.582) with 1-β=0.585; and sleep quality (d = 0.586; g = 0.588) with 1-β=0.638. &lt;strong&gt;Conclusion: &lt;/strong&gt;Essential oils extracted from &lt;em&gt;Rosmarinus officinalis&lt;/em&gt; are more effective in calming anxiety and show moderate changes in depression and sleep quality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">343</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;, Taniht Lisseth Cubas- Romero&lt;sup&gt;1&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hospital de Apoyo Chepén, Chepén, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Autónoma del Perú. Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Francisco Mercedes Infantes Gomez</style></author><author><style face="normal" font="default" size="100%">Natalia Mavila Guzmán Rodríguez</style></author><author><style face="normal" font="default" size="100%">Yolanda Elizabeth Rodríguez de Guzmán</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Roger Antonio Rengifo-Penadillos</style></author><author><style face="normal" font="default" size="100%">José Gilberto Gavidia-Valencia</style></author><author><style face="normal" font="default" size="100%">Iris Melina Alfaro-Beltrán</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Melissa officinalis essential oil on state and trait anxiety</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Melissa officinalis.</style></keyword><keyword><style  face="normal" font="default" size="100%">State anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Trait anxiety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">454-460</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Essential oils are complex substances used extensively in aromatherapy and phytotherapy, some of them as anxiety and stress-relieving agents. In order to evaluate the effects of &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil on state and trait anxiety, this study was conducted. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oil was extracted by steam distillation and the chemical composition was investigated by Gas chromatographymass spectrometry (GC–MS). In addition, a Quasi experimental study with measures at pretest-posttest was conducted, where 58 participants were divided into two groups, a waiting-list (WL) control group, and an experimental group (EG)treated with aromatherapy based on &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil. The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI). Measures were taken at two times: pretest and posttest. &lt;strong&gt;Results&lt;/strong&gt;: The chemical analysis showed that β-cubebene (26.3%), β-caryophyllene (25.4%) and geranial (12.5%) were de main components. Both state and trait anxiety levels decreased in the experimental group during the posttest phase; however, only state anxiety demonstrated statistically significant differences (p&amp;lt;0.05). A moderate size effect was found for state anxiety (d = 0.799; g= 0.797) with 1-β=0.803; but none for trait anxiety. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Melissa officinalis&lt;/em&gt; essential oil was moderately effective on state anxiety but has no effect on trait anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">454</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto- Vásquez&lt;sup&gt;2&lt;/sup&gt;, Francisco Mercedes Infantes Gomez&lt;sup&gt;1&lt;/sup&gt;, Natalia Mavila Guzmán Rodríguez&lt;sup&gt;3&lt;/sup&gt;, Yolanda Elizabeth Rodríguez de Guzmán&lt;sup&gt;4&lt;/sup&gt;, Demetrio Rafael Jara- Aguilar&lt;sup&gt;2&lt;/sup&gt;, Roger Antonio Rengifo- Penadillos&lt;sup&gt;2&lt;/sup&gt;, José Gilberto Gavidia-Valencia&lt;sup&gt;2&lt;/sup&gt;, Iris Melina Alfaro-Beltrán&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Psicología. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Enfermería. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Instituto Pablo Casals, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Lurdes Tuesta-Collantes</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic and Antidepressant-like Effects of Foeniculum vulgare Essential Oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Foeniculum vulgare</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">425-431</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: The aim of this research was to determine the anxiolytic and antidepressant-like effects of the essential oils from &lt;em&gt;Foeniculum vulgare &lt;/em&gt;aerial parts and seeds.&lt;strong&gt; Methods&lt;/strong&gt;: The oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and chemical composition was performed by Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). Furthermore, an experimental trial was conducted, where 117 participants were divided into three groups, comprising a waiting list control group and two experimental groups treated with essential oils. The anxiety and depression indexes were evaluated by Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS). &lt;strong&gt;Results: &lt;/strong&gt;chemical analysis showed that trans- Anethole was the main component, both in the essential oil from aerial parts (35.5%) and seeds (79.2%). Anxiety and depression scores showed a decrease in posttest study phase in comparison with pretest in all experimental groups (p&amp;lt;0.05), except for depression scores in the group treated with essential oil from aerial parts (p&amp;gt;0.05). Small changes were found in the case of anxiety for group treated with essential oils from aerial parts (d = 0.41; Δ= 0.40) while moderate (d = 0.86; Δ = 0.85) and small (d = 0.38; Δ = 0.39) changes were found for anxiety and depression respectively, in the group treated with essential oil from seeds. &lt;strong&gt;Conclusion:&lt;/strong&gt; The essential oil from &lt;em&gt;Foeniculum vulgare&lt;/em&gt; seeds is more effective to relief anxiety than depression while the essential oil from&lt;em&gt; Foeniculum vulgare&lt;/em&gt; aerial parts only exhibit small changes for anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vasquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;1&lt;/sup&gt;, Elda Maritza Rodrigo-Villanueva&lt;sup&gt;2&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, Lurdes Tuesta-Collantes&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Santiago M. Benites</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic-like Effect of Luma chequen Essential Oil: A Pilot Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Luma chequeen.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1607-1613</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Essential oils are complex substances used widely extended in the form of aromatherapy or phytotherapy, some of them as agents to relieve anxiety and stress. In this sense this study was conducted to examine the anxiolytic-like effect of Luma chequen essential oil. &lt;strong&gt;Methods: &lt;/strong&gt;The essential oil was extracted by steam distillation and the chemical composition was investigated by Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). Moreover, a randomized, double blind, placebo-controlled trial was conducted, where 48 participants were divided into two groups, comprising a control group (CG) treated with placebo, and an experimental group (EG) treated with aromatherapy based on Luma chequen essential oil. The anxiety index was evaluated by State-Trait Anxiety Inventory (STAI). Measures were taken at two times: pretest and posttest.&lt;strong&gt; Results:&lt;/strong&gt; The chemical analysis showed that α-pinene was the main component (56.5%). State and Trait anxiety scores showed a decrease in posttest study phase in comparison with pretest in experimental group compared to placebo (p&amp;lt;0.005 for state anxiety and p&amp;lt;0.05 for trait anxiety). Cohen`s d score was 0.84 in State anxiety, while it was 0.52 for Trait anxiety. Percentages of change showed reductions of anxiety variable ranging between 14.94% for State anxiety and 13.60% for Trait anxiety. &lt;strong&gt;Conclusions: &lt;/strong&gt;These results suggest that aromatherapy based on essential oil of Luma chequen was moderately effective in improving anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1607</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado-García&lt;sup&gt;1&lt;/sup&gt;,*, Marilú Roxana Soto-Vásquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;3&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, Santiago M. Benites&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad Autónoma del Perú. Escuela de Psicología. Lima, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ. 4Universidad Autónoma del Perú. Lima, PERÚ&lt;/p&gt;
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