<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gumilar Adhi Nugroho</style></author><author><style face="normal" font="default" size="100%">Febrika Wediasari</style></author><author><style face="normal" font="default" size="100%">Zahra Fadhilah</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">ELFAHMI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potency of Antidiabetic Effects of the Combination of Syzygium cumini and Andrographis paniculata in Rats with High-Fat Dietand Streptozotocin-Induced Diabetes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Combination</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">406-412</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Andrographis paniculata&lt;/em&gt; (AP) and &lt;em&gt;Syzygium cumini &lt;/em&gt;(SC) are known for their antihyperglycemic effects. However, the combined effects of these plants have not yet been assessed. This study evaluated the oral acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antihyperglycemic effects of the extract combining AP and SC (SCAP) in rats with high-fat diet- and streptozotocin (STZ)-induced diabetes. Thirteen female DDY mice for toxicity test were divided into three groups and orally administered one dose SCAP (0, 300, or 2000 mg/kg). On day 15, animals were euthanized, their internal organs were observed, and blood samples were collected for clinical biochemistry analyses.&lt;em&gt; In vivo&lt;/em&gt; antihyperglycemic activity was examined in male Sprague- Dawley rats-induced diabetes. Diabetic rats were assigned to once-daily oral treatment with metformin, AP, SC or SCAP for 1 week. Concerning toxicity, SCAP had no effects on liver and kidney and histology of these organs displayed no abnormalities. Blood glucose levels had a tendency to reduce in treatment groups compared with the findings in the diabetic control group. SCAP treatment protected rats against pancreatic damage. These results illustrated that the combined SCAP treatment had beneficial effects on blood glucose levels and pancreatic β-cell function, in rats-induced diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">406</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gumilar Adhi Nugroho&lt;sup&gt;1&lt;/sup&gt;, Febrika Wediasari&lt;sup&gt;1&lt;/sup&gt;, Zahra Fadhilah&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Heri Setiawan&lt;sup&gt;2&lt;/sup&gt;, Elfahmi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratorium of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, University of Indonesia, Depok, Jawa Barat, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorium of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, Jawa Barat, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Institut Teknologi Bandung, Bandung, Jawa Barat, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zahra Fadhilah</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Gumilar Adhi Nugroho</style></author><author><style face="normal" font="default" size="100%">Febrika Wediasari</style></author><author><style face="normal" font="default" size="100%">Eem Masaenah</style></author><author><style face="normal" font="default" size="100%">Varda Arianti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Leave in Kadipaten, Central Java Indonesia, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-hyperglicemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzigium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1502-1508</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Ethnomedicaly, jamblang (java plum) has been used as antidiabetic treatment in Dayak Tribe. This study aims to evaluate the effectiveness and the safety of the jamblang leaf extract as an antidiabetic. &lt;strong&gt;Objective: &lt;/strong&gt;Evaluate Effecticity of &lt;em&gt;Syzigium cumini&lt;/em&gt; (java plum) as anti-diabetic herb. &lt;strong&gt;Method&lt;/strong&gt;: The antidiabetic activity test, used an animal model which gaven food a high fat diet High Fat Diet (HFD) then it was induced with Streptozotocin injected intraperitoneally. The subjects used in the study were male rats (&lt;em&gt;Ratus novergicus&lt;/em&gt;) Sprague-Dawley strain. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of jamblang extract has anti hyperglycemic activity through decrease of fasting blood glucose point significantly (dose 1, 50mg/ Kg Bw p: &amp;lt;0.0001, dose 2, 100 mg/Kg BW p: &amp;lt;0.0001).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1502</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zahra Fadhilah, Berna Elya*, Heri Setiawan, Gumilar Adhi Nugroho, Febrika Wediasari, Eem Masaenah, Varda Arianti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
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