<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raysa Y. Pratiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Atini Solawati</style></author><author><style face="normal" font="default" size="100%">Rosmalena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alterations in Body Weight, Blood Glucose Levels, and Lipid Profiles in High-Fat Diet-Low Dose Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">High-fat diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Low-dose streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Stable diabetes type 2 profile.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1562-1567</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;New preventive and therapeutic strategies to treat Type 2 diabetes (T2D) continue to be pursued, the complexity of this disease makes it imperative to establish preclinical animal models which must provide accurate similarities to the pathogenesis of diabetes in humans. Making a diabetic animal model using rats with high-fat diet (HFD)-streptozotocin (STZ) induction is popular because it is relatively low cost and simple. &lt;strong&gt;Objectives:&lt;/strong&gt; This study aims to analyse the changes in body weight, blood glucose, and lipid profiles that occur in diabetic rat models created by induction of HFD in combination with lowdose STZ. &lt;strong&gt;Methods: &lt;/strong&gt;This study used forty male Sprague-Dawley rats (200-240 g). After the adaptation period, thirty rats were fed with HFD for 28 days (DM group), while the other ten rats continued to be fed with standard feed (NC group). After then, diabetes was induced to the DM group by low-dose STZ (35 mg/kg BW). The body weight of the rats was measured before and after diet manipulation periods. Blood samples were taken before and after STZ induction to determine lipid profiles and blood glucose levels.&lt;strong&gt; Results:&lt;/strong&gt; During the diet manipulation period, the HFD group experienced a significantly greater weight gain, higher blood glucose levels, and cholesterol (TC) levels. After STZ injection, rats’ blood glucose levels, TC, and triglycerides significantly increased.&lt;strong&gt; Conclusion:&lt;/strong&gt; HFD feeding combined with a low-dose STZ effectively work to mimic specific condition that is similar to T2D, and the stability of the experimental animal conditions remains constant for up to 6 weeks.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raysa Y. Pratiwi&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Heri Setiawan&lt;sup&gt;1&lt;/sup&gt;, Atini Solawati&lt;sup&gt;1&lt;/sup&gt;, Rosmalena&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Dea Firdaus</style></author><author><style face="normal" font="default" size="100%">Nina Artanti</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Rosmalena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Constituents and In vitro Antidiabetic and Antioxidant Properties of Various Extracts of Kenikir (Cosmos caudatus) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">890-895</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (&lt;em&gt;Cosmos caudatus&lt;/em&gt;) &lt;em&gt;kenikir’s &lt;/em&gt;leaves. In previous studies, &lt;em&gt;kenikir's l&lt;/em&gt;eaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of &lt;em&gt;kenikir's&lt;/em&gt; leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various&lt;em&gt; kenikir’s &lt;/em&gt;leave extract. &lt;em&gt;Kenikir’s&lt;/em&gt; leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%. Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p&amp;lt;0.05) and antidiabetic (p&amp;lt;0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of &lt;em&gt;kenikir’s&lt;/em&gt; leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">890</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Dea Firdaus&lt;sup&gt;1&lt;/sup&gt;, Nina Artanti&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Rosmalena&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, South Tangerang, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rosmalena</style></author><author><style face="normal" font="default" size="100%">Putu Ayu Widyastuti</style></author><author><style face="normal" font="default" size="100%">Fatmawaty Yazid</style></author><author><style face="normal" font="default" size="100%">Neneng Siti Silfi Ambarwati</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemicals and Antioxidant Activities Evaluation of Origanum vulgare (L.) Stem Bark Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">2-diphenyl-1-picrylhydrazyl</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare (L.)</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">965-970</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The present study aimed to evaluate phytochemical and antioxidant activity (&lt;em&gt;in vitro&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt;) of &lt;em&gt;Origanum vulgare &lt;/em&gt;(L.) ethanolic extract. The phytochemical test was assessed using the Clule method in ethanol, ethyl acetate, and hexane. &lt;em&gt;In vitro &lt;/em&gt;evaluation of antioxidant activity was determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) as an artificial free radical activity.&lt;em&gt; In vivo &lt;/em&gt;test was conducted to evaluate the effect of malondialdehyde (MDA) level in blood plasma during maximum physical activity treatment.&lt;em&gt; In vivo&lt;/em&gt; test was done using 25 male Sprague Dawley rats in pre and post-test control group design. The phytochemical test of &lt;em&gt;O. vulgare&lt;/em&gt; ethanol extract was showed some compounds, such as a flavonoid, alkaloid, triterpenoid/steroid, essential oil, and tannin, then in ethyl acetate and hexane. &lt;em&gt;In vitro &lt;/em&gt;assay showed that &lt;em&gt;O. vulgare&lt;/em&gt; extract has strong antioxidant activity with an IC&lt;sub&gt;50&lt;/sub&gt; value of 133.47 μg/mL. While in the &lt;em&gt;in vivo&lt;/em&gt; test, the most effective dosage is 20 mg/200 gr B.W., represented by a significant decrease of MDA level (0.509 nmol/mL) before and after treatment. So, the ethanolic extract of clove has potency as an herbal antioxidant because of the low level of IC&lt;sub&gt;50&lt;/sub&gt; and can decrease the MDA level.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">965</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rosmalena&lt;sup&gt;1&lt;/sup&gt;, Putu Ayu Widyastuti&lt;sup&gt;2&lt;/sup&gt;, Fatmawaty Yazid&lt;sup&gt;1&lt;/sup&gt;, Neneng Siti Silfi Ambarwati&lt;sup&gt;3,&lt;/sup&gt;*, Islamudin Ahmad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, 10430 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, 10430 Jakarta, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, 13220 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, INDONESIA.&lt;/p&gt;
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