<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laurente-Pachamango Katherine G</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ricardo M Gomez-Arce</style></author><author><style face="normal" font="default" size="100%">Deivy Y Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Chávez- Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">292-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis.&lt;strong&gt; Results: &lt;/strong&gt;When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p&amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laurente-Pachamango Katherine G&lt;sup&gt;1&lt;/sup&gt;, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,*&lt;/sup&gt;, Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ricardo M Gomez- Arce&lt;sup&gt;3&lt;/sup&gt;, Deivy Y Dionicio-Rosado&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;3&lt;/sup&gt;, Calderón-Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo- Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Chávez- Flores Juana E&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química Biológica y Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Estadística, Facultad de Ciencias Físicas y Matemática, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Horna-Rodriguez Alexsandra M</style></author><author><style face="normal" font="default" size="100%">López-Gamboa July A</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Analysis of the Polyphenolic Metabolites of Zea mays L. &quot;Purple Corn&quot; on HMG-CoA Reductase</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">HMG-CoA reductase.</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Zea mays L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">549-558</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This research aims to identify the polyphenolic metabolites, reported in ears and grains of &lt;em&gt;Zea mays &lt;/em&gt;L. &quot;purple corn&quot; according to the current literature, with more significant interaction on HMG-CoA reductase, through&lt;em&gt; in silico&lt;/em&gt; assays. Using the keyword combination “&lt;em&gt;Zea mays&lt;/em&gt; L” AND “polyphenols”, a search was made in Google Scholar, PubMed, ScienceDirect and Scopus databases, identifying 22 polyphenolic compounds. Polyphenolic ligands and control molecules were prepared with the OpenBabel program and parameterized with AutoDock Tools. In addition, the crystallized structure of HMG-CoA reductase (1DQA) was downloaded from the Protein Data Bank database, then prepared in PyMOL and parameterized with AutoDock Tools. Molecular docking was performed in AutoDock Vina with a 100-time repetition for each ligand-target interaction. The results show that the hydrogen bonds with amino acids of importance in HMG-CoA reductase are ASN 658, ARG 590, and GLU 559. Protocatechuic acid, caffeic acid, vanillic acid, ferulic acid, p-coumaric acid, and 4-hydroxybenzoic acid presented lower affinity energy (ΔG°). The physicochemical and pharmacokinetic properties of the molecules with the best pharmacodynamic interaction were analyzed with the SwissADME and pkCSM servers, showing that protocatechuic, caffeic, vanillic, ferulic, p-coumaric and 4-hydroxybenzoic acids have the best physicochemical and pharmacokinetic profile. Therefore, this study gives us a clearer idea of the action of polyphenols on HMG-CoA reductase, which will allow obtaining new drug candidates for the treatment of hypercholesterolemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">10</style></accession-num><section><style face="normal" font="default" size="100%">549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Horna-Rodriguez Alexsandra M, López- Gamboa July A, Silva-Correa Carmen R, Sagástegui-Guarniz William Antonio, Gamarra-Sánchez Cesar D, Villarreal-La Torre Víctor E*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Universidad Nacional de Trujillo, PERU&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ruiz-Reyes Segundo G</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective and Nephroprotective Activity of Artemisia absinthium L. on Diclofenac-induced Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artemisia absinthium</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1032-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Artemisia absinthium L. is known for its antimalarial activity however, hepatoprotective activity of aqueous extracts has also been reported but, nephroprotective activity not yet evaluated. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the hepatoprotective and nephroprotective activities of &lt;em&gt;A. absinthium &lt;/em&gt;against diclofenac-induced toxicity on rats. Materials and Methods: Three different doses of methanol and ethyl acetate extract of &lt;em&gt;A. absinthium &lt;/em&gt;(50, 100 and 200 mg/kg/day) were evaluated and compared with silymarin 100 mg/kg. Rats received these doses for 5 days and on the 3rd and 4th day diclofenac (50 mg/kg i.p.) was administered 1 h after treatment. Animals were sacrificed 48 h after the last injection of diclofenac. Biochemical blood parameters like aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine, and histopathologic changes of liver and kidney were studied and evaluated. &lt;strong&gt;Results:&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;&lt;em&gt;A. absinthium &lt;/em&gt;reduced the elevated blood levels of ALT, AST, ALP, urea and creatinine with the methanol extract to 200 mg/kg/day being more effective. The histopathologic evaluation suggested that &lt;em&gt;A. absinthium &lt;/em&gt;decreased hepatic and renal necrosis induced by diclofenac. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective and nephroprotective activities of methanol and ethyl acetate extract of &lt;em&gt;A. absinthium&lt;/em&gt; were demonstrated, being methanol extract to 200 mg/kg/day the most effective. This provides scientific support for the use of medicinal plants such as&lt;em&gt; A. absinthium &lt;/em&gt;in the treatment of liver and kidney disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1032</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,&lt;/sup&gt;*, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Calderón- Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo-Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ruiz-Reyes Segundo G&lt;sup&gt;1&lt;/sup&gt;, Chávez-Flores Juana E&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;
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