<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rajkumar S Bagali</style></author><author><style face="normal" font="default" size="100%">Sunil S Jalalpure</style></author><author><style face="normal" font="default" size="100%">SS Patil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-vitro Antioxidant and In-Vivo Hepatoprotective Activity of Ethenolic Extract of Tectona grandis Bark Against CCl4 Induced Liver Injury in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">CCL4 induced hepatopathy</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Quinones</style></keyword><keyword><style  face="normal" font="default" size="100%">Tectona grandis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">598-602</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The systematic screening of &lt;em&gt;Tectona grandis &lt;/em&gt;bark with the purpose of discovering new bioactive compounds as a hepatoprotective agent and to establish the scientific basis for the therapeutic actions of traditional plant medicines. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;Tectona grandis&lt;/em&gt; bark ethenolic extract was studied for the hepatoprotective activity against CCl&lt;sub&gt;4&lt;/sub&gt; induced liver injury in rats. Serum enzymes level, total bilirubin and histopathological study of liver were performed. This extract’s DPPH radical scavenging potential was also studied. &lt;strong&gt;Results: &lt;/strong&gt;Oral administration of ethenolic extract of &lt;em&gt;Tectona grandis &lt;/em&gt;bark (200 mg/kg) exhibited significant reduction (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) in CCl&lt;sub&gt;4&lt;/sub&gt;-induced increased levels of SGPT, SGOT, ALP and bilirubin (Total) concentration. Treatment with Liv 52 syrup also reversed the hepatotoxicity significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Histopathological studies also provided supportive evidence for biochemical analysis. This extract also showed better activity in quenching DPPH radical.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Tectona grandis &lt;/em&gt;bark ethenolic extract shown to have hepatoprotective and antioxidant action due to presence of quinones and tannin like phytoconstituents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">598</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rajkumar S Bagali&lt;sup&gt;1,&lt;/sup&gt;*, Sunil S Jalalpure&lt;sup&gt;2&lt;/sup&gt;, SS Patil&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, K.L.E University, College of Pharmacy, Nehrunagar, Belgaum-10, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, INDIA.&lt;/p&gt;
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