<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lubsandorzhieva PB</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dashinamzhilov Zh.B</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Ferubko EV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Collection and Study of its Hepatoprotective Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatoprotective activity</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">713-721</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aim of this work is pharmacognostic study of herbal formulation consisting of elecampane rhizomes and roots (&lt;em&gt;Inula helenium&lt;/em&gt; L.), fruits of rose (&lt;em&gt;Rosa&lt;/em&gt; sp.) and hawthorn (&lt;em&gt;Crataegus&lt;/em&gt; sp.), leaves of pepper mint (&lt;em&gt;Mentha piperita&lt;/em&gt; L.) and cowberry leaves (&lt;em&gt;Vaccinium vitis-idaea&lt;/em&gt; L.), spiny eleuterococcus rhizomes and roots (&lt;em&gt;Eleutherococcus senticosus &lt;/em&gt;(Rupr.et Maxim.) Maxim., low cudweed herb (&lt;em&gt;Gnaphalium uliginosum&lt;/em&gt; L.s.l.) as well as determination of its hepatoprotective activity. &lt;strong&gt;Materials and methods: &lt;/strong&gt;An electron microscope, HPLC and methods of the State Pharmacopoeia of Russia were used in pharmacognostic study of herbal formulation. The hepatoprotective, antioxidant and choleretic activities of the herbal formulation were studied&lt;em&gt; in vivo&lt;/em&gt; model of liver damage induced by tetracycline hydrochloride and 40% ethanol. &lt;strong&gt;Results: &lt;/strong&gt;The content of biologically active substances (BAS) collected: essential oils - at least 0.30%; flavonoids in terms of luteolin - not less than 1.0%; ascorbic acid - not less than 0.5%; tannins - not less than 3.0%; arbutin - at least 0.4%; eleutheroside B - not less than 0.01%.It has been found that the course administration of herbal formulation to white Wistar rats with liver damage eliminates the prooxidant effect of tetracycline and ethanol, reduces the manifestation of cholestasis and increases the rate of bile secretion for 1-3 hours. &lt;strong&gt;Conclusion: &lt;/strong&gt;The herbal formulation has hepatoprotective activity, antioxidant, choleretic effect and stimulates regenerative and antitoxic processes in the liver in rats with a model of combined liver damage induced tetracycline and ethanol. The obtained research results argue the possibility of using herbal formulation for prevention and complex treatment of liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">713</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lubsandorzhieva PB&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dashinamzhilov Zh.B&lt;sup&gt;1&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;3&lt;/sup&gt;, Ferubko EV&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;All-Russian Research Institute of medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferubko EV</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correction of Toxic Liver Damage with a Multicomponent Herbal Extract in an Animal Experiment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Choleretic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental hepatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Multicomponent extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">168-172</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Digestive diseases constitute a significant part in the overall structure of human diseases. Herbal cholagogues are indicated for a treatment of chronic liver, gall bladder, and bile ducts diseases. The aim of the work is to determine the choleretic effect of a new multicomponent plant extract.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Multicomponent plant extract was obtained from the following types of plant materials: 300 g of immortelle flowers (&lt;em&gt;Helichrysum arenarium&lt;/em&gt; L.), 100 g of tansy flowers (&lt;em&gt;Tanacetum vulgare&lt;/em&gt; L.), 100 g of rose fruits (&lt;em&gt;Rosa &lt;/em&gt;sp.), 100 g of leaves of common nettle (&lt;em&gt;Urtica dioica &lt;/em&gt;L.), 50 g of mint leaves (&lt;em&gt;Mentha piperita&lt;/em&gt; L.), 50 g of licorice roots (&lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; L.). The extract was standardized by the total flavonoid content. It was calculated and expressed in terms of luteolin and isosalipurposide standards (total flavonoids content: not less than 4% and 15% respectively). The animal experiments being done in 80 nonlinear male rats with initial body weight 180-200 g. In order to study a choleretic effect of multicomponent herbal extract, naive rats recieved the single experimental dose of 250 mg/kg. Pharmacotherapeutic activity was studied in white rats with CCl&lt;sub&gt;4&lt;/sub&gt;-induced hepatitis. &lt;strong&gt;Results: &lt;/strong&gt;Studies indicate a pronounced choleretic effect of the studied plant extract, that is comparable with the effect of “Allochol” in intact rats experiments. The course administration of a per os (peroral) multicomponent plant extract in a dose of 250 mg/kg to white non-linear rats with tetrachloromethane liver damage has a choleretic effect: it increases the rate of bile secretion, stimulates the synthesis and secretion of cholates with bile, and also the excretion of cholesterol and bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained research results argue the feasibility of using a multicomponent plant extract containing biologically active substances of phenolic nature in the prevention and comprehensive treatment of liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">168</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ferubko EV&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Rendyuk TD&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferubko EV</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development and Evaluation of New Choleretic Agent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Choleretic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Choleretic herbal medicine Hexaphyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental damage of liver and gallbladder</style></keyword><keyword><style  face="normal" font="default" size="100%">Preclinical studies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">962-966</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The aim of the research is the determination of pharmacological activity during the development of the optimal way of a new choleretic agent obtaining. The multicomponent herbal medicinal product under the code name Hexaphyte (herbal multicomponent dry extract) is developed. It contains the following species of medicine plant raw materials: &lt;em&gt;Helichrysum arenarium&lt;/em&gt; L., &lt;em&gt;Tanacetum vulgare&lt;/em&gt; L., R&lt;em&gt;osa sp&lt;/em&gt;., &lt;em&gt;Urtica dioica&lt;/em&gt; L., &lt;em&gt;Mentha piperita&lt;/em&gt; L., &lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; L. in the ratio of 6:2:2:2:1:1. Materials and Methods: Herbal tea was extracted three times with hot water at the temperature of 75-85ºС; water extracts were combined, filtered and dried. Hexaphyte was standardized by the content of phenolic compounds – sum of flavonoids in terms of luteolin standard and isosalipurposide standard. Phenolic compounds (flavonoids) are dominating substances (35-37%) in the obtained extract. The obtained multicomponent medicine under the code name Hexaphyte was administered per os in the experimental and therapeutic dose of 250 mg/kg to the laboratory animals having experimental induced damages of gallbladder and liver. &lt;strong&gt;Results:&lt;/strong&gt; In Hexaphyte the content of the flavonoid sum (CFS) referred to luteolin standard at a wavelength of 350 nm was not less than 4%; CFS referred to isosalipurposide standard at a wavelength of 315 nm was not less than 15%. It was revealed in the results of the realized experiments that it has a choleretic effect superior in a number of indicators to the activity of the Allochol reference drug. The pharmacotherapeutic effect of Hexaphyte at experimental damages of gallbladder and liver is due to the presence of biologically active substances, mainly of phenolic nature. &lt;strong&gt;Conclusion: &lt;/strong&gt;The obtained results of the research argue the feasibility of using the developed multicomponent medicine Hexaphyte containing biologically active substances of phenolic nature in the prevention and complex treatment of hepatobiliary system diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">962</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ferubko EV&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Barkalova VE</style></author><author><style face="normal" font="default" size="100%">Suslikova MA</style></author><author><style face="normal" font="default" size="100%">Sokhin DM</style></author><author><style face="normal" font="default" size="100%">Kakhramanova SD</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Strelyaeva AV</style></author><author><style face="normal" font="default" size="100%">Antsyshkina AM</style></author><author><style face="normal" font="default" size="100%">Balobanova NP</style></author><author><style face="normal" font="default" size="100%">Prostodusheva TV</style></author><author><style face="normal" font="default" size="100%">Grikh VV</style></author><author><style face="normal" font="default" size="100%">Krasnyuk II1 (junior)</style></author><author><style face="normal" font="default" size="100%">Marakhova AI</style></author><author><style face="normal" font="default" size="100%">Moiseev DV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lathraea squamaria L. (Orobanchaceae): A Review of its Botany, Phytochemistry, Traditional Uses and Pharmacology</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aucubin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Common toothwort</style></keyword><keyword><style  face="normal" font="default" size="100%">Iridoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Lathraea squamaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Orobanchaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Parasitic plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">667-673 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This paper presents the results of the review pharmacognostic study of common toothwort, a perennial plant, parasitizing on the roots of trees. Currently, in Russian traditional medicine, there is considerable experience in the use of сommon toothwort (&lt;em&gt;Lathraea squamaria&lt;/em&gt; L.) herb and roots as antitumoral, biligenic, infertility-treatment and diuretic drugs. The chemical composition of &lt;em&gt;L. squamaria&lt;/em&gt; has not been quite well determined. Phenylethanoid glycosides (acteoside, isoacteoside), iridoid glycosides (aucubin, and aucuboside ester, 6'-O-glucopyranosyl-aucubin, melampyroside, 6'-O-glucopyranosyl melampyroside), simple sugars, fatty acids, organic acids, β-sitosterol were identified. Further study of&lt;em&gt; L. squamaria &lt;/em&gt;raw materials is a very promising field including implementation in official medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">667</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bokov DO&lt;sup&gt;1,2,#,&lt;/sup&gt;*, Barkalova VE&lt;sup&gt;3,#&lt;/sup&gt;, Suslikova MA&lt;sup&gt;1&lt;/sup&gt;, Sokhin DM&lt;sup&gt;1&lt;/sup&gt;, Kakhramanova SD&lt;sup&gt;1,4&lt;/sup&gt;, Rendyuk TD&lt;sup&gt;1&lt;/sup&gt;, Strelyaeva AV&lt;sup&gt;1&lt;/sup&gt;, Antsyshkina AM&lt;sup&gt;1&lt;/sup&gt;, Balobanova NP&lt;sup&gt;1&lt;/sup&gt;, Prostodusheva TV&lt;sup&gt;1&lt;/sup&gt;, Grikh VV&lt;sup&gt;1&lt;/sup&gt;, Krasnyuk II&lt;sup&gt;1&lt;/sup&gt; (junior), Marakhova AI&lt;sup&gt;5&lt;/sup&gt;, Moiseev DV&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pediatrics, Siberian State Medical University, 2 Moscow tract, 634050, Tomsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of State Pharmacopoeia and pharmacopoeia analysis, Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products”, 8/2 Petrovsky Boulevard, Moscow, 127051, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmaceutical chemistry and pharmacognosy chair, Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Chair of Standardization of Medicines, Vitebsk State Medical University, 27, Frunze avenue, Vitebsk, 210062, BELARUS. #Bokov DO, Barkalova V.E. contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saybel OL</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author><author><style face="normal" font="default" size="100%">Khobrakova VB</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic Compounds and Immunomodulating Activity of Chicory (Cichorium intybus L.) Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chicory herb</style></keyword><keyword><style  face="normal" font="default" size="100%">Dry extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulating activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1104-1107</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This research aims to determine the immunomodulating activity of chicory (&lt;em&gt;Cichorium intybus&lt;/em&gt; L.) herb extract and to evaluate the prospects of development of the medicine based on it. &lt;strong&gt;Methods:&lt;/strong&gt; Object of the research was dry chicory extract obtained from herb (aerial part) of a wild plant. The chemical composition of the extract was determined by HPLC-MS method. Its immunomodulating action has been explored &lt;em&gt;in vivo &lt;/em&gt;experiments involving intact animals, as well as immunosuppressed animals, treated with azathioprine cytostatic agent. Chicory extract was administered at a dose of 30 mg/kg per os 1 time per day for 14 days. As a reference drug, Immunal (Lec Pharma, Slovenia) was used. Chicory extract action on the state of cell immune component was evaluated in delayed hypersensitivity reaction. The humoral immunity condition was evaluated by the count of antibody-forming cells determined by the local hemolysis method. The state of the macrophage component of the immune response was evaluated in the phagocytosis reaction of peritoneal macrophages in relation to colloid liquid ink particles. &lt;strong&gt;Results:&lt;/strong&gt; Dry chicory extract is capable to reduce the suppressive azathioprine effect on the cell-mediated immune response, antibody response, and phagocytosis with macrophages; it does not change the immunity indicators in intact animals. &lt;strong&gt;Conclusion: &lt;/strong&gt;Dry chicory extract contains phenolic complex of biologically active substances, namely oxycoumarins, hydroxycinnamic acids, and flavonoids. Dry chicory extract is an effective immunocorrecting agent; it should be recommended for further study and application aiming for the prevention and treatment of immunodeficiency states.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1104</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Saybel OL&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;3&lt;/sup&gt;, Khobrakova VB&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;FSBSI All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;FPFIS Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;
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