<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eko Susetyarini</style></author><author><style face="normal" font="default" size="100%">Poncojari Wahyono</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Endrik Nurrohman</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Stigmasterol from Beluntas Leaves (Pluchea indica) on SGOT and SGPT Levels in Male Rats (Rattus norvegicus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Beluntas</style></keyword><keyword><style  face="normal" font="default" size="100%">Men</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety Test</style></keyword><keyword><style  face="normal" font="default" size="100%">Stigmasterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1311-1314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Stigmasterol compounds have the potential as natural male antifertility drugs; based on the results of multiyear research and bioinformatics, further research is needed on the safety of stigmasterol preclinically. The study aimed to examine selected stigmasterol from blunt leaves that are safe for blood SGOT and SGPT levels the type of experimental research, the Post-test control design group. The study was conducted at the Biomedical Laboratory of the University of Muhammadiyah Malang, the Hufaka Bandung Laboratory, and the FKH Laboratory of Brawijaya University. The study was conducted from June to August 2024. The research sample of stigmasterol from blunt leaves came from the UPT materia medica of Batu City. The sampling technique was purposive random sampling. There were three dose treatments (0.125 mg/kgbb, 0.25 mg/kgbb, 0.5 mg/kgbb and control) with seven replications. Data analysis used one-way ANOVA and Duncan's further test. The results showed that giving various doses of stigmasterol could reduce SGPT in the blood but not SGOT. Duncan's test results of SGOT levels showed no significant difference between treatment categories; SGPT testing showed that the 0.125 mg/kgbb and 0.25 mg/kgbb treatments were not significantly different from the 0.5 mg/kg bb treatment but were substantially different from the control treatment. At the same time, the 0.5 mg/kgbb treatment was not significantly different from the other treatments. The conclusion and findings of the stigmasterol compound are in the safe category for use because it does not cause an increase in blood SGOT and SGPT and potentially tends to decrease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1311</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eko Susetyarini&lt;sup&gt;1*&lt;/sup&gt;, Poncojari Wahyono&lt;sup&gt;1&lt;/sup&gt;, Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Endrik Nurrohman&lt;sup&gt;1&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biology Education Study Program, Faculty of Teacher Training and Education, Universitas Muhammadiyah Malang, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Em Sutrisna</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Aris Fitriani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Effect of Nigella sativa L. Seed from Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus epidermidis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1029-1032</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Nigella sativa &lt;/em&gt;L. was allegedly to has antibacterial effect. The aim of this research is to investigate antibacterial effect of ethanolic extracts of 96% &lt;em&gt;Nigella sativa&lt;/em&gt; L. from Indonesia toward &lt;em&gt;Staphylococcus&lt;/em&gt; aureus, &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and Streptococcus epidermidis. The Antibacterial activity of of &lt;em&gt;Nigella sativa&lt;/em&gt; L toward &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and &lt;em&gt;Streptococcus&lt;/em&gt; &lt;em&gt;epidermidis &lt;/em&gt;using the well method. The 96% ethanolic extract of 12,5; 25;50 and 100% (mg/ml)inhibit growth of &lt;em&gt;Staphylococcus&lt;/em&gt; &lt;em&gt;aureus&lt;/em&gt; (with inhibition zone 11.06; 29.58; 28.22; 30.84 mm respectively) and &lt;em&gt;Streptococcus epidermidis&lt;/em&gt; (20.90; 31.90; 29.93; 33.07 mm respectively). Ethyl acetate fraction of 96% ethanolic extract of &lt;em&gt;Nigella sativa &lt;/em&gt;concentration of 6,25; 12,5; 25;50 and 100% (mg/ml) inhibit growth of &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (12.91; 15.06; 19.19; 37.48; 46.18 mm respectively and Streptococcus epidermidis (19.07; 19.21; 20.22; 21.62; 40.00 mm respectively). Ethanolic 96% extract and ethyl acetate fraction of ethanolic extract of &lt;em&gt;Nigella sativa&lt;/em&gt; have antibacterial effect toward &lt;em&gt;Staphylococcus&lt;/em&gt; aureus and &lt;em&gt;Streptococcus epidermidis invitro.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1029</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Em Sutrisna&lt;sup&gt;1,*&lt;/sup&gt;, Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Aris Fitriani&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Politeknik Kesehatan Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Em Sutrisna</style></author><author><style face="normal" font="default" size="100%">Maryati</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Tanti Azizah S</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Effect of Phyllanthus niruri L. from Indonesia (Pre-clinical Study)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1347-1350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesian people often use &lt;em&gt;Phyllanthus niruri&lt;/em&gt; L. (&lt;em&gt;P. niruri&lt;/em&gt; L.) to treat pain. Pain is the one of symptoms of inflammation. Some people take traditional medicine to treat this pain, because some analgesic drugs have several adverse effects. The aim of this research is to explore the anti-inflammatory effect of ethyl asetat fraction of ethanolic extract of &lt;em&gt;P. niruri&lt;/em&gt; L. (EAPN) from Indonesia in rats induced by carrageenan. A total of 25 rats were divided into 5 groups. Group 1 (diclofenac sodium 50 mg/kgbb), group 2 (aqueous extract), groups 3,4and 5 were ethyl asetat fraction at dosage of 250; 500 and 1000 mg/kgbw respectively. Group 1 was treated by diclofenac sodium at dose of 50 mg/kgbw, group II was treated by aqueous 2mL/rats, groups III, IV and V were treated by EAPN at dosage of 250; 500 and 1000mg/kgbw respectively. Thirty minutes later, all rats were injected by carrageenan 0,1 mL 1% w/v sub cutaneous into back rat’s left paw. Paw volumes were measured by Plethysmometer on minutes 0, 60, 90, 150, 210, 330. Area under the curve (AUC) were calculated from these results (AUC 0-30; AUC 0-90; 0-150; AUC 0-210 and AUC 0-330). The AUC of EAPN at dosage of 250; 500 and 1000mg/ kgbw smaller than negative control significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). EAPN contains alkaloids, flavonoids, terpenoids, saponins and triterpens. EAPN has anti-inflammatory effect in rats induced by carrageenan.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1347</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Em Sutrisna&lt;sup&gt;1&lt;/sup&gt;,*, Maryati&lt;sup&gt;2&lt;/sup&gt;, Sri Wahyuni&lt;sup&gt;2&lt;/sup&gt;, Tanti Azizah S&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical faculty of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy faculty of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;
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