<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Coronado-Olano</style></author><author><style face="normal" font="default" size="100%">Ritva Repo-Carrasco-Valencia</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author><author><style face="normal" font="default" size="100%">Emily Toscano</style></author><author><style face="normal" font="default" size="100%">Elisa Valdez</style></author><author><style face="normal" font="default" size="100%">Mirko Zimic</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory activity against α-amylase and α-glucosidase by phenolic compounds of quinoa (Chenopodium quinoa Willd.) and cañihua (Chenopodium pallidicaule Aellen) from the Andean region of Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andean grains</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">896-901</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Chenopodium quinoa&lt;/em&gt; Willd. and &lt;em&gt;Chenopodium pallidicaule&lt;/em&gt; Aellen are grains from the Andean region of Peru, which in addition to having a high nutritional value, have health-promoting properties related to the prevention of chronic diseases such as diabetes. &lt;strong&gt;Objetive:&lt;/strong&gt; The present study aimed to identify phenolic compounds associated with an inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Two varieties of quinoa and two varieties of cañihua from the Puno Region in Peru, were evaluated. Total phenolics, total flavonoids, identification of phenolic compounds and antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; were measured by Folin-Ciocalteu assay, aluminum chloride colorimetric method, HPLC-DAD and DPPH radical scavenging assay, respectively. &lt;em&gt;In vitro &lt;/em&gt;hypoglycemic activity was evaluated through the inhibition of the α-amylase and α-glucosidase enzymes. Results: Gallic acid, rutin and chlorogenic acid were identified by HPLC-DAD in the varieties of quinoa and cañihua. The latter showed significantly higher levels of chlorogenic acid compared to quinoa varieties (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Both Andean grains exhibited inhibition of key-enzymes linked to type 2 diabetes, presenting IC&lt;sub&gt;50&lt;/sub&gt; values of 7.99 to 34.05 and of 8.07 to 1158 μg/mL for α-amylase and α-glucosidase, respectively. Total phenolics, total flavonoids, DPPH radical scavenging assay, gallic acid and chlorogenic acid showed the greatest contribution to the inhibitory activity of the α-glucosidase enzyme (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings suggest that the phenolic compounds present in the varieties of quinoa and cañihua could modulate the inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">896</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Coronado-Olano&lt;sup&gt;1,5&lt;/sup&gt;, Ritva Repo-Carrasco-Valencia&lt;sup&gt;1&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;2&lt;/sup&gt;, Emily Toscano&lt;sup&gt;3&lt;/sup&gt;, Elisa Valdez&lt;sup&gt;4&lt;/sup&gt;, Mirko Zimic&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;6,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Carrera de Ingeniería Agroforestal, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Nacional Federico Villarreal, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Unidad de Investigación en Nutrición, Salud, Alimentos Funcionales y Nutracéuticos, Universidad San Ignacio de Loyola (UNUSANUSIL), Calle Toulon 310, 15024 Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paola Raunelli</style></author><author><style face="normal" font="default" size="100%">Danae Liviac</style></author><author><style face="normal" font="default" size="100%">Rafael Alvis</style></author><author><style face="normal" font="default" size="100%">Silvio Puente</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytoprotective Effect of the Eryngium foetidum &quot;Sacha Culantro&quot; Methanolic Leaf Extract Versus Sodium Fluoride Exposed Mice using the Micronucleus Test and the Comet Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Comet assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Eryngium foetidum</style></keyword><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Micronucleus test</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">461-465</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Eryngium foetidum&lt;/em&gt;, commonly known as sacha culantro, is a plant that grows in the Peruvian Amazonian jungle, studied for its high concentration of antioxidant substances and various ethnopharmacological properties. The main goal of the study is to observe the cytoprotective and antioxidant effect of the extract from its leafs in &lt;em&gt;Mus musculus&lt;/em&gt; previously administered with Sodium fluoride (NaF) using the Micronucleus test and the Comet assay. &lt;strong&gt;Methods: &lt;/strong&gt;The extract was administrated orally in four different concentrations: 180, 360, 720, 1440 mg/Kg for ten days, at the 11&lt;sup&gt;th&lt;/sup&gt; day a single dose of NaF was administrated via intraperitoneal at 20 mg/Kg. The genotoxicity study was made with mice from the strain BALB/c, using the Micronucleus test on bone marrow and the Comet assay on peripheral blood according the OECD guides 474 and 489 respectively. The statistical analysis was made by the media’s analysis with ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;Significant differences were found in Micronucleus frequency between the highest concentrations of &lt;em&gt;Eryngium foetidum&lt;/em&gt; and NaF. The Comet assay showed significant reduction in NaF induced damage according to different concentrations of the extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;Eryngium foetidum&lt;/em&gt; extract has cytoprotective activity against oxidant substances such as NaF.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">461</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paola Raunelli&lt;sup&gt;1,2&lt;/sup&gt;, Danae Liviac&lt;sup&gt;3&lt;/sup&gt;, Rafael Alvis&lt;sup&gt;3&lt;/sup&gt;, Silvio Puente&lt;sup&gt;4&lt;/sup&gt;, Ivan Best&lt;sup&gt;1,5,6&lt;/sup&gt; Oscar Reátegui&lt;sup&gt;1,7,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Nutrition and Dietetic School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Agroforestry Engineering School, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Danae Liviac</style></author><author><style face="normal" font="default" size="100%">Paola Raunelli</style></author><author><style face="normal" font="default" size="100%">Rafael Alvis</style></author><author><style face="normal" font="default" size="100%">Silvio Puente</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis, In vitro Antioxidant Capacity and Toxicity Assessment of Copaifera paupera Oleoresin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Comet assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Copaifera paupera</style></keyword><keyword><style  face="normal" font="default" size="100%">Micronucleus test</style></keyword><keyword><style  face="normal" font="default" size="100%">Oleoresin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">374-378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The present study was taken to determine the phytochemical analysis, the antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; (FRAP and TBARS methodologies), the oral acute toxicity and antigenotoxicity of the oleoresin &lt;em&gt;Copaifera paupera&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; The oleoresin was tested for &lt;em&gt;in vivo&lt;/em&gt; cytoprotective capacity using the Micronucleus Test and the Comet Assay in mice bone marrow cells and mice erythrocytes cells, respectively.&lt;strong&gt; Results:&lt;/strong&gt; The oleoresin had low levels of total flavonoids and phenol content and also of antioxidant capacity. Orally, the LD50 appeared to be &amp;gt; 5000 mg/kg (no toxic or low toxic). The results showed all the doses evaluated (180 360, 720 and 1440 mg/kg) antigenotoxic effect by reduce the DNA damage induced by cyclophosphamide, being a 100 % DNA damage reduction at the highest dose evaluated. &lt;strong&gt;Conclusion:&lt;/strong&gt; According to the Micronucleus test, the oleoresin Copaifera paupera had the ability of increase the cell proliferation despite the exposition of cyclophosphamide. (abstract is not arranged properly, improper sentences)&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">374</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Danae Liviac&lt;sup&gt;1&lt;/sup&gt;, Paola Raunelli&lt;sup&gt;2&lt;/sup&gt;, Rafael Alvis&lt;sup&gt;1&lt;/sup&gt;, Silvio Puente&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;2,4,5&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;3* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology. Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Agroforestry Engineering. Universidad Científica del Sur, Panamericana Sur Km 19, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Grupo de Ciencia, Tecnología e Innovación en Alimentos, Universidad San Ignacio de Loyola, Lima, PERU.&lt;/p&gt;
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