<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nahid Mahmoud Hassan El-Ameen</style></author><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Asaad Khalid</style></author><author><style face="normal" font="default" size="100%">Fatima Elfatih</style></author><author><style face="normal" font="default" size="100%">Mona Awad Kamel</style></author><author><style face="normal" font="default" size="100%">Bassem Yousif Sheikh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-diabetic Properties of Thymoquinone is unassociated with Glycogen Phosphorylase Inhibition</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycogen phosphorylase inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Thymoquinone.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">406-410</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Nigella sativa&lt;/em&gt; L. (Black seed), is commonly used by traditional healers as a remedy for more than four thousand years. The antidiabetic property of &lt;em&gt;N. sativa&lt;/em&gt; seeds oil is attributable to the presence of Thymoquinone (TQ). On the other hand many studies have been designed to investigate the possible effects of the TQ in Streptozotocin (STZ) and nicotinamide (NA)-induced diabetes in rats. &lt;strong&gt;Aim of the study: &lt;/strong&gt;The aim of this study was to elucidate the mechanisms underlying the glucose lowering effects of thymoquinone. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; and &lt;em&gt;in silico&lt;/em&gt; using glycogen phosphorylase (GPa) enzyme assay and docking tools were used. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of TQ for 60 days, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. GPa activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phosphate. TQ at a concentration of 0.05 Mm inhibits GPa activity by only 14.9%. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results show that TQ at 60 mg/kg b.w is associated with potential antihyperglycemic effects. Furthermore, anti-diabetic properties of TQ are unassociated with glycogen phosphorylase inhibition.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">406</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nahid Mahmoud Hassan El-Ameen&lt;sup&gt;1*&lt;/sup&gt;, Manal Mohamed Elhassan Taha&lt;sup&gt;1*&lt;/sup&gt;, Siddig Ibrahim Abdelwahab&lt;sup&gt;1&lt;/sup&gt;, Asaad Khalid&lt;sup&gt;1&lt;/sup&gt;, Fatima Elfatih&lt;sup&gt;2&lt;/sup&gt;, Mona Awad Kamel&lt;sup&gt;1&lt;/sup&gt; and Bassem Yousif Sheikh&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Research Unit, Researcher at Medical Research Center, Jazan University, Jazan, Saudi Arabia.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry Medicinal and Aromatic Plants Research Institute, National Centre for Research, P. O. Box 2420 Khartoum, Sudan.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Surgery, MABL Chair, College of Medicine, Taibah University, Saudi Arabia.&lt;/p&gt;</style></auth-address></record></records></xml>