<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meri Susanti</style></author><author><style face="normal" font="default" size="100%">Sanusi Ibrahim</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between High Performance Thin Layer Chromatography and High Performance Liquid Chromatography Methods for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">High Performance Liquid Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">High performance Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">rubraxanthone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s42-s47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To develop simple, rapid, accurate methods for determination of rubraxanthone in the stem bark extract of &lt;em&gt;Garcinia cowa&lt;/em&gt; using High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC). &lt;strong&gt;Methods:&lt;/strong&gt; The HPTLC method was performed on aluminum plate precoated with silica gel 60 F254 using Chloroform: Ethyl acetate: Methanol: Formic acid (88:2:2:8) as a developing system. Quantification was achieved using densitometric measurements at 243 nm. The HPLC method involved a 5 &amp;mu;m C18 column and an isocratic solvent using 0.4% formic acid: methanol (12:88) with a flow rate 1 mL minute-&lt;sup&gt;1&lt;/sup&gt;. Quantitation was also achieved with ultraviolet detection at 243 nm based on peak area. All necessary validation tests for both methods were done for their comparison. The results obtained by these two different quantification methods were compared by Tukey&amp;rsquo;s-test. &lt;strong&gt;Results:&lt;/strong&gt; Both assays provided good linearity, accuracy, precision, specificity and limits of detection and quantitation for determination of rubraxanthone in The Stem Bark extract of &lt;em&gt;G. cowa.&lt;/em&gt; &lt;strong&gt;Conclusion:&lt;/strong&gt; Both methods revealed reasonable validation parameters concerning linearity, accuracy, precision, specificity and limits of detection and quantitation. A statistical comparison of the quantitative analysis of rubraxanthone in extract did not show any statistically significant difference between two analysis methods. As both methods were found to be equal, they therefore can be used for the analysis of rubraxanthone in the Stem Bark extract of &lt;em&gt;G. cowa&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s42</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Meri Susanti&lt;sup&gt;1&lt;/sup&gt;, Sanusi Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;3&lt;/sup&gt;, Dachriyanus&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, INDONESIA.&lt;/p&gt;</style></auth-address></record></records></xml>