<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Risya Amelia Rahmawanti</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Brenda Cristie Edina</style></author><author><style face="normal" font="default" size="100%">Lowilius Wiyono</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nanoparticle Synthesis and Cytotoxicity of Kaempferia pandurata Roxb. Extract to the Growth of MDA-MB-231 Breast Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia pandurata Roxb.</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Temu Kunci</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">109-114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is the most common cancer worldwide and in Indonesia. &lt;em&gt;Kaempferia pandurata &lt;/em&gt;Roxb. is a herbal plant from South-East Asia which is known for its ability to inhibit the growth of Estrogen Receptor (ER) + breast cancer cell line from the former study. However, its effect on ER- breast cancer cell lines had not been studied. Therefore, we want to examine the cytotoxicity effect of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. on ER- breast cancer cell line (MDA-MB-231). Nanoparticle is a form of preparation that optimizes the activity of any compound to the targeted cell. Therefore, it is expected that it can increase the effectivity of anticancer in &lt;em&gt;Kaempferia pandurata&lt;/em&gt; Roxb. In this study, the rhizome of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. trituration was dried and extracted with n-hexane solvent. Nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. was synthesized with CaCl&lt;sub&gt;2&lt;/sub&gt;, chitosan, and alginate by stirring with a magnetic stirrer, adjusting pH, and centrifugation. Then, nanoparticle was analized by UV/VIS spectrofotometry and transmission electron microscopy (TEM). The cytotoxicity of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract and nanoparticle were examined with MTT assay. The result of this test is data of inhibition percentage and IC&lt;sub&gt;50&lt;/sub&gt; value. The result showed that n-hexane extract of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. is synthesized into nanoparticle form with 99,43% yield percentage (entrapment value). Anticancer activity of n-hexane extract and nanoparticle of&lt;em&gt; K. pandurata&lt;/em&gt; Roxb. is moderate with IC&lt;sub&gt;50&lt;/sub&gt; value of the extract is 87,23 μg/ml and the nanoparticle is 24,23 μg/ml. The nanoparticle’s activity is better than the extract. n-Hexane extract and nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. has cytotoxicity effects towards MDA-MB-231 cell line. Nanoparticle can increase the cytotoxicity effect of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract because its hydrophobic feature and nanometer size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">109</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Risya Amelia Rahmawanti&lt;sup&gt;1&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2,3,&lt;/sup&gt;*, Brenda Cristie Edina&lt;sup&gt;1&lt;/sup&gt;, Lowilius Wiyono&lt;sup&gt;1&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Undergraduate Medical Student, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Center – IMERI, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Vincent Kharisma Wangsaputra</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author><author><style face="normal" font="default" size="100%">Hiroki Tanimoto</style></author><author><style face="normal" font="default" size="100%">Kiyomi Kakiuchi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis, Characterization, and Cytotoxicity Evaluation of Gallic Acid Nanoparticles Towards Breast T47D Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">321-327</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Gallic acid is a naturally polyphenolic acid which shows cytotoxicity against several cancer cells, as well as it displays chemo-preventive activity which is attributed to its strong apoptosis- inducing and antioxidant effects. Thus, gallic acid has become an attractive substance to be further developed due to its strong cytotoxic activity. This study aimed to synthesize gallic acid nanoparticle coating with alginate-chitosan, and evaluate its cytotoxicity against breast T47D cancer cells.&lt;strong&gt; Methods: &lt;/strong&gt;Gallic acid nanoparticle was synthesized using ionic gelation method. The yield, size and morphology of the nanoparticles were determined by UV-Vis Spectroscopy, Transmission electron microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. Cytotoxicity evaluation of gallic acid nanoparticle towards breast T47D cancer cell is carried out by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Spherical nanoparticles of gallic acid with the size of 100-200 nm has been successfully synthesized in 96% of yield. Compared to gallic acid (IC&lt;sub&gt;50&lt;/sub&gt;: 20.86 μg/mL) and alginate-chitosan nanoparticle (IC&lt;sub&gt;50&lt;/sub&gt;: 38.46 μg/mL), gallic acid coating with alginate-chitosan nanoparticles demonstrated higher cytotoxicity towards breast T47D cancer cells with IC&lt;sub&gt;50 &lt;/sub&gt;value of 9.03μg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results clearly confirmed that gallic acid nanoparticles coating with alginate-chitosan showed a strong cytotoxicity towards breast T47D cancer cells, which is potential to be developed as a candidate for new anti-breast cancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">321</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Anton Bahtiar&lt;sup&gt;3&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,2&lt;/sup&gt;, Vincent Kharisma Wangsaputra&lt;sup&gt;4&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt;, Hiroki Tanimoto&lt;sup&gt;5&lt;/sup&gt;, Kiyomi Kakiuchi&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation And In Vivo Effect of Essential Oil From Cinnamommum Burmannii as Antiobesity With Leptin Receptor In The Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt; olfactory system, leptin receptors, &lt;em&gt;Cinnamomum burmannii&lt;/em&gt;, docking simulation, immunohistochemistry&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi,1 Aryo Tedjo,&lt;sup&gt;2&lt;/sup&gt; Fadilah Fadilah,&lt;sup&gt;2&lt;/sup&gt; Ade Arsianti,&lt;sup&gt;2&lt;/sup&gt; Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA. *e-mail : fika.paramita@gmail.com / rafikaindah@ ui.ac.id&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii</style></keyword><keyword><style  face="normal" font="default" size="100%">docking simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">leptin receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">olfactory system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">875-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice Balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">875</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record></records></xml>