<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/514</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">492-496</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">492</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt;, Ethanol, Methanol, U87 cell line, Antiproliferative.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record></records></xml>