<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Priya K Gopal</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis and Screening of Anti-Proliferative Potential of Methanolic Extract of Garcinia cowa on Different Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-proliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolomic profiling</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">347-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Garcinia cowa&lt;/em&gt; (Clusiaceae) is popular among integrative medicine in several communities. This study undertook to evaluate the anti-proliferative activity on cancer cells and its cytotoxic effect on normal cells. Here we are reporting for the first time the metabolomic profiling of &lt;em&gt;G. cowa&lt;/em&gt; leaf. &lt;strong&gt;Methods: &lt;/strong&gt;Anti-proliferative potential of ethyl acetate and methanol extract of &lt;em&gt;Garcinia cowa&lt;/em&gt; leaf assessed by MTT assay. Metabolomic profiling obtained by GC/ MS analysis. Nuclear morphology visualized by DAPI staining. Caspase activation analysed through spectrophotometric assay.&lt;strong&gt; Results:&lt;/strong&gt; The study reveals, that the methanolic extract is more potential in inducing anti-proliferative activity than ethyl acetate extract. Robust antiproliferative activity of the methanolic extract evidenced in lung cancer cell line, A549 followed by MCF–7, HepG2, MOLT – 4, MDA-MB-468 cells. The anti-proliferative effect was negligible in normal PBMC. Further, a dose-dependent increase of nuclear fragmentation visualized in A549 cells treated with the methanolic extract. Post methanolic extract treatment upregulation of caspase-3 and caspase-9 also evidenced in A549 cells. GC/MS analysis revealed the presence of phytoconstituents of different phytochemical groups comprising of 3.45% diterpenoid, 5.45% triterpenoid, 11.24% steroid, 2.03% phytosterol, etc. in methanol extract, as well as 4.53% diterpenoid, 2.88% triterpenoid, 1.09% steroid, 2.11% phytosterol, etc. in ethyl acetate extract with considerable biological importance. &lt;strong&gt;Conclusion:&lt;/strong&gt; This is the maiden report of the metabolomic profiling of leaf extracts of&lt;em&gt; Garcinia cowa&lt;/em&gt; which possess a good repository of potentially bioactive molecules that holds a great promise as a future therapeutic agent in combating lung cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">347</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anirban Chouni, Amrita Pal, Priya K Gopal, Santanu Paul*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, Kolkata 700019, West Bengal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amrita Pal</style></author><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Arpan Das</style></author><author><style face="normal" font="default" size="100%">Ribhu Ray</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-proliferative Potential and Antioxidant Activity of a Wild Edible Mushroom Macrocybe crassa (Sacc.) Pegler and Lodge</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Macrocybe crassa</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF7</style></keyword><keyword><style  face="normal" font="default" size="100%">MOLT-4</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1504-1510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aims to quantify the anti-oxidant activity of the methanolic extract of &lt;em&gt;Macrocybe crassa &lt;/em&gt;and its anti-proliferative activity on normal and cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The anti-oxidant potential of the extract was determined by several&lt;em&gt; in vitro&lt;/em&gt; assay system like DPPH radical scavenging activity, superoxide anion scavenging activity, percentage inhibition of lipid peroxidation and nitric oxide (NO) scavenging activity. Anti-proliferative activity was tested by MTT assay on breast cancer cell line MCF7, Human acute T lymphoblastic leukaemic cell MOLT-4 and Peripheral Blood Mononuclear Cells or PBMC isolated from a healthy donor to check its cytotoxic effect on normal cells. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that the methanolic extract of &lt;em&gt;Macrocybe crassa&lt;/em&gt; shows appreciable anti-proliferative activity against breast cancer cell line MCF7 and negligible effect on MOLT4 cells. In contrast no significant anti-proliferative effect has been observed in normal PMMCs. Moderate anti-oxidant activity was recorded in methanolic extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Methanolic extract of of &lt;em&gt;Macrocybe crassa&lt;/em&gt; with moderate anti-oxidant activity and specific anti-proliferative effect on MCF7 holds a great promise can be used for isolation of bio molecules for treating Breast Cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amrita Pal, Anirban Chouni, Arpan Das, Ribhu Ray, Santanu Paul* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anirban Chouni</style></author><author><style face="normal" font="default" size="100%">Santanu Paul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review on Phytochemical and Pharmacological Potential of Alpinia galanga</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">1’s’-1’- Acetoxychavicolacetate</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpinia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/357#ref28</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">09-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; From the ancient Vedic era, green plants are being used for their medicinal properties to treat several diseases. Green plants represent a big source of bioactive compounds. &lt;em&gt;Alpinia galanga&lt;/em&gt; (Linn.) of Zingiberaceae family is one amongst those medicinally important plants. Different parts of the plant are used in the treatment of many diseases for its anti-fungal, anti-tumour, antimicrobial, anti-inflammatory, anti-diabetic, antioxidant, antiulcer and many other properties. Several active compounds such as 1&amp;rsquo;S-1&amp;rsquo;-acetoxychavicol acetate, 1&amp;rsquo;S-1&amp;rsquo;-acetoxyeuginol acetate, 1, 8-cineol, &amp;alpha;-fenchyl acetate, &amp;beta;-farnesene, &amp;beta;-bisabolene, &amp;alpha;-bergamotene, &amp;beta;-pinene, &amp;beta;-Sitosteroldiglucoside (AG-7), &amp;beta;-sitsterylArabinoside (AG-8), 1&amp;rsquo;-acetoxychavicol acetate (galangal acetate), p-hydroxycinnamaldehyde has been extracted from the plant. &lt;strong&gt;Methods:&lt;/strong&gt; Relevant information was collected from scientific journals, books, and reports via electronic search using Medline, PubMed, Science Direct and Scopus. &lt;strong&gt;Results:&lt;/strong&gt; This review provides a comprehensive report on &lt;em&gt;Alpinia galanga&lt;/em&gt; having anti-proliferative, apoptotic, anti angiogenic as well as cytotoxic efficacy and their mode of action &lt;em&gt;in vitro&lt;/em&gt; as well as &lt;em&gt;in vivo&lt;/em&gt; condition. &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the ability of the golden treasure present in &lt;em&gt;Alpinia galanga&lt;/em&gt;, this review is aimed to summarize the information of the chemical constituents, pharmacological and therapeutic effects of the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">9</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anirban Chouni and Santanu Paul*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Laboratory of Cell and Molecular Biology, Department of Botany, University of Calcutta, Kolkata 700019, West Bengal, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>