<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Li ChangSheng</style></author><author><style face="normal" font="default" size="100%">Chimgee Tserendash</style></author><author><style face="normal" font="default" size="100%">Maral-Erdene Gerelt-Od</style></author><author><style face="normal" font="default" size="100%">Batdavaa Batbayar</style></author><author><style face="normal" font="default" size="100%">Uyangamaa Altankhuyag</style></author><author><style face="normal" font="default" size="100%">Mend-Amar Batbaatar</style></author><author><style face="normal" font="default" size="100%">Narankhajid Myadagsuren</style></author><author><style face="normal" font="default" size="100%">Davaadagva Damdinjav</style></author><author><style face="normal" font="default" size="100%">Enkhmaa Gonchig</style></author><author><style face="normal" font="default" size="100%">Yeruult Chultemsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute and Subchronic Toxicity Study of Sampilnorov Wurile</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute and subchronic toxicity; biochemistry; blood test; histopathological analysis; Sampilnorov Wurile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">203-210</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sampilnorov Wurile (SW) is a traditional medicinal preparation containing 29 plant-, mineral-, and animal-derived components. It is used for cerebrovascular ischemia, retinal disorders, cardiovascular diseases, and neurological conditions. This study aimed to evaluate the acute and subchronic toxicities of SW. &lt;strong&gt;Methods: &lt;/strong&gt;Acute toxicity was assessed in C57BL/6 mice based on OECD-423 guidelines, with oral doses ranging from 500 to 6,000 mg/kg body weight. Subchronic toxicity was evaluated in Wistar rats following OECD-407 guidelines, with daily oral doses of 300 and 600 mg/kg of SW daily for 4 weeks. Clinical signs, mortality, body weight, and physical condition were monitored. Hematological, biochemical, and histopathological analyses were conducted on day 29. &lt;strong&gt;Results:&lt;/strong&gt; No mortality or significant clinical signs of toxicity were observed at doses up to 6,000 mg/kg, suggesting an oral median lethal dose exceeding this level. Subchronic toxicity assessment revealed no clinical signs of toxicity or mortality. SW at 300 and 600 mg/kg had no significant effects on serum biochemical parameters or vital organ histology compared to controls.&lt;strong&gt; Conclusion:&lt;/strong&gt; SW exhibited no acute toxicity at doses up to 6,000 mg/kg and showed no adverse effects in a 28-d subchronic toxicity study. These findings support its safety at tested doses.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">203</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Li ChangSheng&lt;sup&gt;1&lt;/sup&gt;, Chimgee Tserendash&lt;sup&gt;2&lt;/sup&gt;, Maral-Erdene Gerelt-Od&lt;sup&gt;2&lt;/sup&gt;, Batdavaa Batbayar&lt;sup&gt;2&lt;/sup&gt;, Uyangamaa Altankhuyag&lt;sup&gt;2&lt;/sup&gt;, Mend-Amar Batbaatar&lt;sup&gt;2&lt;/sup&gt;, Narankhajid Myadagsuren&lt;sup&gt;3&lt;/sup&gt;, Davaadagva Damdinjav&lt;sup&gt;4&lt;/sup&gt;, Enkhmaa Gonchig&lt;sup&gt;2,*&lt;/sup&gt;, Yeruult Chultemsuren&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Mongolian Medicine Surgery, College of Mongolian Medicine, Inner Mongolia Medical University, China; No 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous region, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasad Arvind Thakurdesai</style></author><author><style face="normal" font="default" size="100%">Pallavi Onkar Deshpande</style></author><author><style face="normal" font="default" size="100%">Savita Raju Nimse</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-aging Efficacy and Safety of Topical Application of Two Standardized Fenugreek Seed Extracts on Facial Skin in Women: Randomized, Double-Blind, Placebo-Controlled, Clinical Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-aging</style></keyword><keyword><style  face="normal" font="default" size="100%">Fenugreek seed extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin elasticity</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin hydration</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">470-479</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Fenugreek (&lt;em&gt;Trigonella foenum graecum L.&lt;/em&gt;) is widely used in culinary and medicinal applications and has recently gained attention for its potential anti-aging properties. &lt;strong&gt;Objectives: &lt;/strong&gt;This randomized, double-blind, placebo-controlled study evaluated the anti-aging efficacy and safety of topical application of flavonoid glycosides-based and eleutheroside-oligosaccharide-based standardized fenugreek seed extract creams, namely INDUS1520 and INDUS1530, respectively. &lt;strong&gt;Methods: &lt;/strong&gt;Seventy-five healthy women aged between 35 and 55 years with mild to moderate facial wrinkles were randomly allocated to receive either INDUS1520, INDUS1530, or a Placebo cream for 60 days. Efficacy outcomes included skin luminescence, color, trans-epidermal water loss, moisture content, gloss, elasticity, firmness, wrinkle depth, surface roughness, and collagen distribution. Safety was assessed using a dermatological assessment and subject-reported intolerance questionnaire for adverse events. &lt;strong&gt;Results:&lt;/strong&gt; INDUS1530 significantly improved skin hydration and wrinkle depth, while INDUS1520 significantly reduced transepidermal water loss compared with Placebo. Both creams showed a trend of decreased skin roughness and increased collagen distribution, although this difference was not statistically significant between the groups. All treatments, including Placebo, increased skin gloss. No adverse events or skin irritation were observed. &lt;strong&gt;Conclusions: &lt;/strong&gt;Both fenugreek seed extract creams were well tolerated and demonstrated potential anti-aging benefits, with INDUS1530 showing more pronounced effects on skin hydration and wrinkle reduction. These findings support the use of standardized fenugreek seed extracts as safe and effective ingredients in anti-aging skin care products.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">470</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasad Arvind Thakurdesai&lt;sup&gt;1*&lt;/sup&gt;, Pallavi Onkar Deshpande&lt;sup&gt;1&lt;/sup&gt;, Savita Raju Nimse&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Indus Biotech Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune, INDIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Carlos Orlando Garcia-Bustamante</style></author><author><style face="normal" font="default" size="100%">Edwin Cesar Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Jessica Yolanda Huarcaya-Rojas</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Julio Jose Pena-Galindo</style></author><author><style face="normal" font="default" size="100%">Esther Obdulia Franco-Soto</style></author><author><style face="normal" font="default" size="100%">Juana E. Chavez-Flores</style></author><author><style face="normal" font="default" size="100%">Robert Armando Cardenas-Orihuela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Neuroprotective Effects of Chuquiraga spinosa Less. and Baccharis genistelloides (Pers.) Lam. in a Rat Model of Transient Cerebral Ischemia-reperfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cerebral ischemia; neuroprotection; antioxidants; Chuquiraga spinosa Less.; Baccharis genistelloides (Pers.) Lam</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">620-631</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cerebral ischemia, a leading cause of disability and mortality, is strongly related to oxidative stress and inflammation, highlighting the need for neuroprotective antioxidant and cytokinemodulating agents. &lt;strong&gt;Objective: &lt;/strong&gt;To characterize the phytochemical profile and evaluate the antioxidant and neuroprotective effects of hydroalcoholic extracts of&lt;em&gt; Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG), individually and in combination, in a rat model of cerebral ischemia–reperfusion. &lt;strong&gt;Methodology: &lt;/strong&gt;Phytochemical screening and GC-MS were performed with antioxidant assays (ABTS•⁺, DPPH•, FRAP). Neurological deficit was assessed (Bederson scale), while histopathology, oxidative stress markers (MDA, GSH, SOD, CAT, NOx), and cytokines (IL-6, TNF-α, IL-1β) were measured. Groups included Normal (no ischemia), Ischemia (oral placebo), Citicoline 300 mg/kg, ChS 500 mg/kg, BaG 500 mg/kg, and the oral combination ChS 500 + BaG 500 mg/kg, all administered for seven days prior to ischemia induction. &lt;strong&gt;Results: &lt;/strong&gt;ChS had higher total phenolic content than BaG (p = 0.0079). GC-MS identified 23 compounds in ChS and 17 in BaG. The combination displayed greater antioxidant activity than either extract. At 24 h, ChS 500 mg/Kg and the combination reduced severe neurological deficit to 17% (vs. 83% in ischemia). Histopathology revealed less neuronal damage with the combination, comparable to ChS 500 mg/Kg. All treatments decreased MDA levels; the combination also enhanced GSH and CAT and significantly reduced TNF-α and IL-1β. &lt;strong&gt;Conclusion:&lt;/strong&gt; ChS and BaG extracts exert neuroprotective effects against cerebral ischemia. Their combination shows synergistic antioxidant activity against free radicals and enhances the modulation of inflammatory cytokines, supporting a greater neuroprotective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">620</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1*&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Miriam Palomino- Pacheco&lt;sup&gt;2&lt;/sup&gt;, Carlos Orlando García-Bustamante&lt;sup&gt;1&lt;/sup&gt;, Edwin César Cieza-Macedo&lt;sup&gt;1&lt;/sup&gt;, Jessica Yolanda Huarcaya-Rojas&lt;sup&gt;3&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;3&lt;/sup&gt;, Julio José Peña-Galindo&lt;sup&gt;3&lt;/sup&gt;, Esther Obdulia Franco-Soto&lt;sup&gt;3&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;4&lt;/sup&gt;, Robert Armando Cárdenas-Orihuela&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos,Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Científica del Sur, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Academic Program of Pharmacy and Biochemistry, Universidad Norbert Wiener, Lima, PERÚ&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patcharin Singdam</style></author><author><style face="normal" font="default" size="100%">Anussara Kamnate</style></author><author><style face="normal" font="default" size="100%">On-Anong Somsap</style></author><author><style face="normal" font="default" size="100%">Ruhainee Tohkayomatee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Phytochemical, Antioxidant, and Antibacterial Study of Different Solvent Extracts of Cissus hastata Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cissus hastata</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">511-519</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Plants have long been utilized in traditional medicine for treating a variety of diseases. Plant-derived extracts are a rich source of phytochemicals with documented antibacterial and antioxidant properties. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to investigate and compare the phytochemical profiles, antioxidant capacities, and antibacterial activities of various crude extracts from the leaves of &lt;em&gt;Cissus hastata.&lt;/em&gt; &lt;strong&gt;Methods: &lt;/strong&gt;Leaf extracts of &lt;em&gt;C. hastata&lt;/em&gt; were prepared using hexane (Hex), ethyl acetate (EtOAc), 95% ethanol (EtOH), and 50% ethanol (AqE). These extracts were analyzed for preliminary phytochemical constituents, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (DPPH, ABTS, and FRAP assays), and antibacterial activity against five bacterial strains: Staphylococcus aureus (TISTR 517), methicillin-resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (MRSA 142)&lt;em&gt;, Bacillus cereus&lt;/em&gt; (ATCC 11778), &lt;em&gt;Escherichia coli &lt;/em&gt;(ESBL 182), and &lt;em&gt;Salmonella typhimurium &lt;/em&gt;(TISTR 292). &lt;strong&gt;Results: &lt;/strong&gt;Phytochemical screening of different solvent extracts of &lt;em&gt;C. hastata&lt;/em&gt; leaves revealed the presence of diverse bioactive compounds. The EtOAc and AqE extracts exhibited the highest TPC (65.31 ± 1.85 and 61.45 ± 3.34 mg GAE/g extract, respectively) (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05). In contrast, the EtOH extract showed the highest TFC (29.92 ± 3.42 mg QE/g extract) (p &amp;lt; 0.05). The EtOH and AqE extracts also demonstrated the strongest antioxidant activities in the DPPH (IC50: 307.07 ± 7.18 μg/mL and 316.86 ± 11.78 μg/mL), ABTS (IC50: 160.21 ± 5.43 μg/mL and 208.45 ± 3.84 μg/ mL) (p &amp;lt; 0.05), and FRAP (4.69 ± 0.08 and 4.96 ± 0.07 mM FeSO4/mg extract) assays. The antibacterial activity was observed exclusively against Gram-positive bacteria. Among all the extracts, the AqE extract at a concentration of 100 mg/mL exhibited significant antibacterial effects against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Bacillus cereus, with zones of inhibition measuring 15.43 ± 0.46 mm, 14.76 ± 0.58 mm, and 15.66 ± 1.04 mm, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol-based extracts of&lt;em&gt; C. hastata&lt;/em&gt; leaves demonstrate high antioxidant and antibacterial activities and represent a promising source of bioactive compounds for developing natural therapeutic agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">511</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Patcharin Singdam&lt;sup&gt;1*&lt;/sup&gt;, Anussara Kamnate&lt;sup&gt;2&lt;/sup&gt;, On-Anong Somsap&lt;sup&gt;3&lt;/sup&gt;, Ruhainee Tohkayomatee&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomy, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ali Napiah Nasution</style></author><author><style face="normal" font="default" size="100%">Juanto Tiojaya</style></author><author><style face="normal" font="default" size="100%">Stephanie</style></author><author><style face="normal" font="default" size="100%">Erny Tandanu</style></author><author><style face="normal" font="default" size="100%">Suandy Suandy</style></author><author><style face="normal" font="default" size="100%">Andre Budi</style></author><author><style face="normal" font="default" size="100%">Masdalena Nasution</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of the Effectiveness of Cream Extracts and VEGF Expression on Incision Wounds in Male Wistar Rats Treated with Ethanol Extracts of Papaya Leaf, Fruit Flesh, and Seeds (Carica Papaya L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Incision wound; Male Wistar rats; Papaya; VEGF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">28-39</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Papaya (Carica papaya Linn) is a tropical fruit plant known for its medicinal benefits, including wound healing. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to analyze and compare the potential of papaya leaf, fruit, and seed extracts in accelerating incision wound healing in male Wistar rats. Additionally, we compared the flavonoid content and stability of the extracts in cream formulations. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Creams containing 30% ethanol extracts of papaya leaf, fruit, and seeds were prepared and applied to the backs of male Wistar rats for two weeks. The wound diameter, epithelial thickness, fibroblast count, macrophage count, collagen density, and VEGF expression were measured after two weeks. &lt;strong&gt;Results: &lt;/strong&gt;Our findings revealed no significant differences between the effects of the papaya leaf, fruit, and seed ethanol extracts on wound diameter, epithelial thickness, fibroblast count, macrophage count, and collagen density (p &amp;gt; 0.05). There were also no significant differences when compared to the negative control group (p &amp;gt; 0.05). The highest flavonoid content was found in the ethanol extract of papaya leaves. Application of the ethanol extract creams of leaf, fruit, and seeds had a significant effect on angiogenesis, as evidenced by VEGF expression (p = 0.002).&lt;strong&gt; Conclusion: &lt;/strong&gt;Papaya leaf, fruit, and seed extracts are promising products for wound healing. Further research is recommended to conduct periodic histopathological examinations during the wound healing process and to explore different extract concentrations for optimal results.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">28</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ali Napiah Nasution*, Juanto Tiojaya, Stephanie, Erny Tandanu, Suandy Suandy, Andre Budi, Masdalena Nasution&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biomedical Sciences, Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rudresh Adarkar</style></author><author><style face="normal" font="default" size="100%">Chandrashekar K S</style></author><author><style face="normal" font="default" size="100%">Vasudev Pai</style></author><author><style face="normal" font="default" size="100%">Richard Lobo</style></author><author><style face="normal" font="default" size="100%">Aswatharam H N</style></author><author><style face="normal" font="default" size="100%">Vamshi Krishna Tippavajhala</style></author><author><style face="normal" font="default" size="100%">Ullas Prakash D’Souza</style></author><author><style face="normal" font="default" size="100%">Rajesh Kaverikana Shankara</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Comprehensive Review on the Pharmacological Potential of Dioscorea bulbifera and its Potential Hepatotoxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">air potato</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Dioscorea bulbifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">520-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Dioscorea bulbifera&lt;/em&gt;, or the air potato has been studied and used in traditional medicine for centuries particularly in countries like China and India. It is loaded in different secondary metabolites such as steroidal saponins, flavonoids, diterpenoids, tannins, and carotenoids, which all play a major role in its pharmacological activities. Researchers have shown that it can be useful in the treatment of inflammation, microbial infections, oxidative stress, cancer, and liver diseases. even with these benefits there remains a shortage of clinical trials, toxicity assessment, and standardized extraction procedures to facilitate its application in herbal drug industry in a safe manner. One of the most striking features of &lt;em&gt;Dioscorea bulbifera&lt;/em&gt; is its antimicrobial activity especially in the fight against antibiotic-resistant bacteria. also, studies done on anticancer activity are actively being conducted with some compounds being reported to induce apoptosis in cancer cells and suppress the growth of tumour. However, talking about its drawbacks some diterpenoid compounds such as diosbulbin A have been reported to show hepatotoxicity in humans and hence further studies are required to determine its safety for therapeutic purposes. The other significant challenge to developing this plant as a standard drug is its variability in chemical composition. The bioactive content is dependent on its cultivation, so it is quite a challenge to control for consistent potency. Sophisticated analytical methods such as HPLC and LC-MS could be utilized to overcome this and contemporary drug delivery systems like nano-formulations could enhance its absorption and bioavailability. Bringing together the ancient herbal knowledge and new scientific inquiry might reveal even greater therapeutic applications of the plant constituents. In the future the studies need to penetrate deeply into its safety, carry out extensive clinical trials, and explore sustainable mechanisms for massproducing its major compounds. With additional studies,&lt;em&gt; Dioscorea bulbifera&lt;/em&gt; could become a prominent natural medicine, providing solutions for numerous health conditions while maintaining its traditional medicinal significance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">520</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rudresh Adarkar&lt;sup&gt;1&lt;/sup&gt;, Chandrashekar K S&lt;sup&gt;1*&lt;/sup&gt;, Vasudev Pai&lt;sup&gt;1&lt;/sup&gt;, Richard Lobo&lt;sup&gt;1&lt;/sup&gt;, Aswatharam H N, Vamshi Krishna Tippavajhala&lt;sup&gt;2&lt;/sup&gt;, Ullas Prakash D’Souza&lt;sup&gt;3&lt;/sup&gt;, Rajesh Kaverikana Shankara&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University, K S Hegde Medical Academy), Deralakatte, Mangaluru, Karnataka, INDIA – 575018.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pravanjan Kumar Tripathy</style></author><author><style face="normal" font="default" size="100%">Manas Ranjan Mishra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Detail Study of an Ethnomedicinal Plant Sarcostemma Acidum Voigt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnomedicinal uses</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological Effects</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Sarcostemma acidum Voigt</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">188-190</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Sarcostemma acidum&lt;/em&gt; Voigt is a leafless plant of the family Apocynaceae. Plant is locally known as Somlata. It is a traditional medicinal plant used to prepare Somras. Geographically &lt;em&gt;S.acidum&lt;/em&gt; is mainly found in Bihar, West Bengal, Odisha and South India. It is mostly grown in dry rocky places. &lt;em&gt;S.acidum&lt;/em&gt; is a shrub , more branched but no leaves. The phytochemicals present in the &lt;em&gt;S.acidum&lt;/em&gt; are carbohydrates, glycosides, alkaloids, tannins, flavonoids, proteins, steroids, triterpenoids, fixed oils, mucilage, gums and waxes. Ethnomedicinally the&lt;em&gt; S.acidum&lt;/em&gt; was used in otitis, dog bite, snake bite, rabies, emesis, arthritis and leprosy. The juice of this plant having some medicinal value, so used as natural restorative for health. S.acidum stem extract inhibits spermatogenesis and reduce the sperm count. Also the extract of&lt;em&gt; S.acidum&lt;/em&gt; shown antipsychotic effect. The result of present pharmacological study shown that the &lt;em&gt;S.acidum&lt;/em&gt; possess Analgesic, Antipyretic and Antidiabetic effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">188</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pravanjan Kumar Tripathy&lt;sup&gt;1&lt;/sup&gt;, Manas Ranjan Mishra&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Biju Patnaik University of Technology, Rourkela, Odisha, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor &amp;amp; HOD, Dept. of Pharmacognosy, Gayatri College of Pharmacy, Odisha, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aasia Kanwal</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdi Mahmood</style></author><author><style face="normal" font="default" size="100%">Mahad Butt</style></author><author><style face="normal" font="default" size="100%">Hidayat Ur Rahman</style></author><author><style face="normal" font="default" size="100%">Norhida Ramli</style></author><author><style face="normal" font="default" size="100%">Saiful Bahri Talip</style></author><author><style face="normal" font="default" size="100%">Showkat Ahmad Bhawani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Components of Gamma Oryzanol on Toll-Like Receptor 4: Receptor Structure-Based Pharmacophore, Hit Identification, and In Silico Evidence</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma oryzanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycystic ovarian syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR4 antagonist</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">329-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Polycystic ovarian syndrome is a leading cause of female infertility. Inflammation has a central role in infertility. Persistent activation of Toll-like receptor 4 contributes to inflammation in PCOS. Gamma-oryzanol consists of esters of ferulic acid combined with phytosterols and triterpene alcohol derivatives of rice bran oil, and is known to have anti-inflammatory effects. However, the structural interaction of different gamma-oryzanol compounds with TLR4 remains unknown. &lt;strong&gt;Objectives: &lt;/strong&gt;The study aimed to investigate gamma oryzanol compounds as hit compounds and inhibitors of Toll-like receptor 4 by developing a pharmacophore model through a receptor structure-based approach coupled with molecular docking studies with the Molecular Operating Environment (MOE) software. &lt;strong&gt;Methods: &lt;/strong&gt;A structure-based pharmacophore model was generated from the co-crystalized structure of the TLR4– MD2 complex. Gamma-oryzanol derivatives were evaluated against the constructed pharmacophore model to identify potential hit compounds. The potential hit compounds that satisfied essential pharmacophoric features were subjected to molecular docking with TLR4. &lt;strong&gt;Results:&lt;/strong&gt; The pharmacophore consisted of three characteristics: a hydrogen bond donor, a hydrogen bond acceptor, and a hydrophobic. Cycloartenyl ferulate, 24-methylenecycloartenyl ferulate, Campesteryl ferulate, and β-sitosteryl ferulate were found to be the hit compounds against the generated pharmacophore. The docking experiment showed that Cycloartenyl ferulate had the most potent binding interaction with TLR4 (7.9933), followed by 24-methylenecycloartenyl ferulate (-7.8580), Campesteryl ferulate (-6.1675), and β-sitosteryl ferulate (-5.9673). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present pharmacophore modeling and docking findings predict that gammaoryzanol may bind with the TLR4 ligand binding domain, providing structural insights into their therapeutic potential role as a modulator of the TLR4-mediated inflammatory pathway. These findings provide a theoretical foundation for future in vitro and in vivo validation studies aimed at elucidating the mechanistic basis of gamma-oryzanol’s anti-inflammatory activity in PCOS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aasia Kanwal&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Hamdi Mahmood&lt;sup&gt;1&lt;/sup&gt;, Mahad Butt&lt;sup&gt;2&lt;/sup&gt;, Hidayat Ur Rahman&lt;sup&gt;1&lt;/sup&gt;, Norhida Ramli&lt;sup&gt;1&lt;/sup&gt;, Saiful Bahri Talip&lt;sup&gt;1&lt;/sup&gt;, Showkat Ahmad Bhawani&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine &amp;amp; Health Sciences, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medicine, Allama Iqbal Medical College, 54550 Lahore, PAKISTAN. 3Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rivan Virlando Suryadinata</style></author><author><style face="normal" font="default" size="100%">Gabriel Tirtawijaya</style></author><author><style face="normal" font="default" size="100%">Sawitri Boengas</style></author><author><style face="normal" font="default" size="100%">Priscilla Keshia Jayasaputri</style></author><author><style face="normal" font="default" size="100%">Henriette Milda Latuputty</style></author><author><style face="normal" font="default" size="100%">Nisa Kirania Dianti Mulyadi</style></author><author><style face="normal" font="default" size="100%">Nawal Fajril Haya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Beltfish (Trichiurus lepturus) Protein Intake and Physical Activity on Muscle Mass Growth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malnutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle Mass</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Intake</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichiurus lepturus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">714-717</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Malnutrition cases have increased every year. One of the causes is insufficient food intake, marked by a decrease in muscle mass. Preventing malnutrition can be done by increasing muscle mass through providing daily protein intake according to needs and engaging in physical activity. The fish species Trichiurus lepturus is a high-protein source from the sea. The protein content in this fish can help promote muscle mass growth. This study aims to determine the effectiveness of protein intake from Trichiurus lepturus combined with physical activity on increasing muscle mass. The research method is experimental, using test animals (Rattus norvegicus) given protein intake and physical activity for 28 days. The animals were divided into six groups: three control groups and three treatment groups receiving different protein levels. Muscle growth was assessed by observing the enlargement of the cruris muscle using HE (hematoxylin and eosin) staining under a 4x microscope magnification. The data obtained were analyzed using ANOVA with an Bonferroni test. The results showed a significant difference between all groups (p=0.000). The treatment groups receiving protein intake and physical activity had larger muscle sizes compared to the control groups (P≤0.05). The conclusion is that protein intake accompanied by physical activity causes changes in muscle mass. Additionally, the amount of protein intake is directly proportional to the increase in muscle size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">714</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rivan Virlando Suryadinata&lt;sup&gt;1*&lt;/sup&gt;, Gabriel Tirtawijaya&lt;sup&gt;2&lt;/sup&gt;, Sawitri Boengas&lt;sup&gt;1&lt;/sup&gt;, Priscilla Keshia Jayasaputri&lt;sup&gt;1&lt;/sup&gt;, Henriette Milda Latuputty&lt;sup&gt;1&lt;/sup&gt;, Nisa Kirania Dianti Mulyadi&lt;sup&gt;1&lt;/sup&gt;, Nawal Fajril Haya&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sawitree Wongtangtintharn</style></author><author><style face="normal" font="default" size="100%">Sirirath McCloskey</style></author><author><style face="normal" font="default" size="100%">Rungruedee Thiwthong</style></author><author><style face="normal" font="default" size="100%">U-sa Thongpairoj</style></author><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Free Radical Scavenging and Anticancer Activities of Methanolic Twig Extract of Annonaceae Plant</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annonaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer cell selectivity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Goniothalamus elegans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">362-365</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The Annonaceae family represents a promising source of bioactive compounds with potential therapeutic applications. This study aimed to comprehensively evaluate the antioxidant and anticancer potential of methanolic twig extracts from seven Annonaceae species. &lt;strong&gt;Methods: &lt;/strong&gt;Twig specimens from &lt;em&gt;Cananga latifolia, Goniothalamus elegans, Goniothalamus tamirensis, Melodorum fructicosum, Polyalthia dubia, Polyalthia cerasoides&lt;/em&gt;, and &lt;em&gt;Uvaria fauveliana&lt;/em&gt; were subjected to standardized methanolic extraction. Antioxidant activity was assessed using DPPH radical scavenging assay. Anticancer potential was evaluated through Sulforhodamine B assay against three human cancer cell lines and normal human dermal fibroblasts at 25 μg/mL concentration. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Goniothalamus elegans&lt;/em&gt; demonstrated exceptional antioxidant activity (IC50 = 5.62 ± 1.21 μg/mL) comparable to ascorbic acid. In anticancer evaluation, &lt;em&gt;G. elegans &lt;/em&gt;exhibited remarkable cytotoxicity against MCF-7 (95.19 ± 0.62%) and HeLa (94.46 ± 1.69%) cancer cells while demonstrating exceptional selectivity with minimal toxicity toward normal cells (19.72 ± 1.19%). Melodorum fructicosum showed highest activity against HT-29 colon cancer cells (75.84 ± 1.57%). &lt;strong&gt;Conclusions:&lt;/strong&gt; &lt;em&gt;Goniothalamus elegans&lt;/em&gt; demonstrated exceptional dual bioactivity with both potent antioxidant properties and selective anticancer effects. The remarkable selectivity indices and broad-spectrum anticancer activity suggest significant clinical potential. These findings provide scientific validation for traditional medicinal uses of Annonaceae species.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sawitree Wongtangtintharn&lt;sup&gt;1&lt;/sup&gt;, Sirirath McCloskey&lt;sup&gt;2&lt;/sup&gt;, Rungruedee Thiwthong&lt;sup&gt;3&lt;/sup&gt;, U-sa Thongpairoj&lt;sup&gt;3&lt;/sup&gt;, Surapong Rattana&lt;sup&gt;4*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Science, Faculty of Agriculture, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Science, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Science, Faculty of Education, Nakhon Phanom University, Nakhon Phanom, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandhinee Thiagaraj</style></author><author><style face="normal" font="default" size="100%">Lekha Ashokkumar</style></author><author><style face="normal" font="default" size="100%">Ram Sabarish</style></author><author><style face="normal" font="default" size="100%">Balaji SK</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-silico Analysis of Molecular Interaction Between Silk Proteins with BMP-2 Type IA and Type II Receptors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">biopolymer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibroin</style></keyword><keyword><style  face="normal" font="default" size="100%">HADDOCK</style></keyword><keyword><style  face="normal" font="default" size="100%">RMSD</style></keyword><keyword><style  face="normal" font="default" size="100%">Sericin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">378-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Alveolar ridge defects are commonly associated with delayed tooth replacement. Natural biomaterial with enhanced regenerative potential is always sought after as a primary choice for ridge reconstruction. Silk, a biopolymer with its constituent proteins (fibroin and sericin) has recently demonstrated promising outcomes in vitro. However, the molecular mechanism by which this occurs remains to be elucidated.&lt;strong&gt; Objective: &lt;/strong&gt;We assessed the molecular interactions between silk proteins bone morphogenetic protein (BMP)-2 type IA and type II receptors using molecular docking. &lt;strong&gt;Methodology:&lt;/strong&gt; The N-terminal domain of silk proteins and structural complex of BMP-2 type IA and type II receptors were considered for protein–protein docking using the high ambiguity-driven protein–protein docking (HADDOCK) server. HADDOCK scores are a measure of the predicted stability of the protein–protein complex, and a lower score indicates a more stable complex and a higher affinity for binding.&lt;strong&gt; Results: &lt;/strong&gt;The HADDOCK scores and root mean square deviation value for interaction between silk proteins with BMP-2 type IA and type II receptors were (−114.2 ± 25.0 and −143.1 ± 11.3) and (2.9 ± 0.4 and 1.9 ± 0.5), respectively, for fibroin and (−1.8 ± 15.6 and −9.7 ± 25.2) and (3.5 ±0.3 and 0.9 ± 0.6), respectively, for sericin. &lt;strong&gt;Conclusion: &lt;/strong&gt;The interaction between fibroin and BMP-2 receptors was more stable with higher affinity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nandhinee Thiagaraj, Lekha Ashokkumar*, Ram Sabarish, Balaji SK&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Periodontology, Sri Ramachandra Dental College and Hospital, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author><author><style face="normal" font="default" size="100%">Ichwan Baihaki</style></author><author><style face="normal" font="default" size="100%">Maria Selvester Thadeaus</style></author><author><style face="normal" font="default" size="100%">Yuni Setyaningsih</style></author><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-Silico Study of Bioactive Compounds from Moringa oleifera Fruit as Anti Premature Senescence Agents in Cardiac Cells: A Study on the p53 Protein</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">cellular senescence</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">p53 protein</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">497-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cellular senescence, characterized by irreversible cell cycle arrest, contributes significantly to the pathogenesis of cardiovascular diseases through mechanisms involving oxidative stress and activation of p53-mediated signaling. &lt;em&gt;Moringa oleifera&lt;/em&gt;, widely recognized for its antioxidant properties, has demonstrated anti-aging effects; however, the specific bioactive compounds within its fruit and their mechanisms of action remain poorly understood. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to investigate the potential of &lt;em&gt;M. oleifera &lt;/em&gt;fruit-derived compounds as anti-premature senescence agents targeting the p53 protein using in-silico molecular docking approaches. Methods: Bioactive compounds from &lt;em&gt;M. oleifera&lt;/em&gt; fruit were screened via molecular docking against the human p53 protein, with Nutlin-3 used as a positive control. Binding affinities, hydrogen bonding, and hydrophobic interactions were analyzed to determine ligand– receptor interactions. &lt;strong&gt;Results: &lt;/strong&gt;Niacin and oxalic acid exhibited stronger binding affinities (–5.90 and –6.00 kcal/mol, respectively) compared to Nutlin-3 (–5.64 kcal/mol). Niacin formed stable hydrogen bonds and hydrophobic interactions with key residues within the p53 active site, suggesting a capacity to modulate p53 activity. Oxalic acid demonstrated the highest binding affinity but lacked hydrogen bonding, indicating potential instability despite strong interaction. These findings support previous studies highlighting &lt;em&gt;M. oleifera's &lt;/em&gt;role in ROS suppression and p53 modulation, pointing to its therapeutic relevance in mitigating cellular aging. &lt;strong&gt;Conclusion: &lt;/strong&gt;Niacin and oxalic acid from &lt;em&gt;M. oleifera&lt;/em&gt; exhibit promising binding characteristics as modulators of the p53 pathway. Their anti-senescence potential warrants further validation through molecular dynamics simulations and biological assays. This study supports the development of natural compound-based therapeutics for age-related cardiac degeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;, Ichwan Baihaki&lt;sup&gt;1*&lt;/sup&gt;, Maria Selvester Thadeaus&lt;sup&gt;1,2&lt;/sup&gt;, Yuni Setyaningsih&lt;sup&gt;1,2&lt;/sup&gt;, Mila Citrawati&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aniruddha Kulkarni</style></author><author><style face="normal" font="default" size="100%">Manoj Tare</style></author><author><style face="normal" font="default" size="100%">Meera Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mucuna Pruriens Seeds Extract Loaded Phytosomal Intranasal Gel for the Effective Treatment of Parkinson’s Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">L-Dopa extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Mucuna pruriens</style></keyword><keyword><style  face="normal" font="default" size="100%">Nasal gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Optimization</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">129-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One phytoconstituent derived from Mucuna pruriens (legumes) is levodopa. This medication's oral usage is limited by its high first-pass metabolism and low absorption. The goal of the present research was to develop a phytosomal gel filled with levodopa extract for better delivery and brain targeting. Various techniques, including solvent evaporation, salting out anti-solvent precipitation, direct egg yolk, and egg lipids methods, were used to create phytosomal formulations. Scanning electron microscopy, particle size, x-ray diffraction, and other techniques were used to characterize phytosomes. And added into gel formation, the more successful batch was examined for several parameters. The final batch underwent a variety of animal tests, including pharmacokinetic analysis, irritation to the nasal cavity testing. The most effective phytosomes were those made via the antisolvent precipitation approach. In this investigation, a 3&lt;sup&gt;2&lt;/sup&gt;-randomized complete factorial design was employed. Batch F4 had an entrapment efficiency of 70%, a particle size of 15 (μg) and 60% CDR. The gel-formulated batch F4G3 demonstrated improved results in terms of extrudability (90.82), amount of drug (89.32%), viscosity (5421 cps at 100 rpm), and spreadability (25.18). Batch F4G3 of the Mucuna pruriens phytosome gel exhibited Higuchi's kinetics. According to the findings of the animal study, dopamine levels were significantly elevated. The pharmacokinetic and nasal irritation studies showed notable in vitro penetration of the nasal mucosa without resulting in skin irritation. For improving Parkinson's disease treatment, the phytosomal gel formulation delivered via the nasal route would be the ideal option.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aniruddha Kulkarni&lt;sup&gt;1*&lt;/sup&gt;, Manoj Tare&lt;sup&gt;2&lt;/sup&gt;, Meera Singh&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune, 410401 INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Sitabai Thite College of Pharmacy (B. Pharm), Shirur, Pune Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune, M.S. INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patcharin Singdam</style></author><author><style face="normal" font="default" size="100%">Anussara Kamnate</style></author><author><style face="normal" font="default" size="100%">On-Anong Somsap</style></author><author><style face="normal" font="default" size="100%">Ruhainee Tohkayomatee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antioxidant Potential, and α-Glucosidase Inhibition of Causonis trifolia Leaf Extracts: A Solvent-Based Comparative Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Causonis trifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">164-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Medicinal plants are used in diabetes mellitus due to their proven minimal adverse effects in humans. &lt;em&gt;Causonis trifolia&lt;/em&gt; leaves have been used as traditional medicine for various treatments. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of this research was to investigate the phytochemicals, the total flavonoid and phenolic content, and in-vitro antioxidant and antidiabetic activities of the extracts of &lt;em&gt;C. trifolia &lt;/em&gt;leaves. &lt;strong&gt;Method:&lt;/strong&gt; The leaves of &lt;em&gt;C. trifolia&lt;/em&gt; were sequentially extracted with maceration in hexane, ethyl acetate, ethanol, and 50% ethanol. Then, the &lt;em&gt;C. trifolia&lt;/em&gt; leaf extracts were assessed for antioxidant activity by the DPPH and ABTS radical scavenging and FRAP assay. Total phenolic and flavonoid contents were determined by the Folin- Ciocalteu and aluminum chloride colorimetric methods, respectively. Antidiabetic activity was evaluated by determination of α-glucosidase inhibitory effect. &lt;strong&gt;Results:&lt;/strong&gt; Preliminary phytochemical analysis of ethanol and 50% ethanol extracts of &lt;em&gt;C. trifolia&lt;/em&gt; leaves showed positive results for alkaloids, coumarin, tannins, saponins, cardiac glycosides, terpenoids, and steroids. The 50% ethanol extract had the best antioxidant activities of the three antioxidant assays (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05). The results revealed higher phenolic and flavonoid contents in 50% ethanol extract than in the other extracts (p &amp;lt; 0.05). Moreover, the 50% ethanol extract exhibited the best potential as α-glucosidase inhibitors of all the extracts and acarbose (&lt;em&gt;p &lt;/em&gt;&amp;lt; 0.05). &lt;strong&gt;Conclusions:&lt;/strong&gt; The results conclude that the &lt;em&gt;C. trifolia&lt;/em&gt; leaves with 50% ethanol as the solvent possessed the potential to extract the highest levels of phytochemical content and have potential antioxidant and α-glucosidase inhibitory activities for diabetic therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">164</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Patcharin Singdam&lt;sup&gt;1*&lt;/sup&gt;, Anussara Kamnate&lt;sup&gt;2&lt;/sup&gt;, On-Anong Somsap&lt;sup&gt;3&lt;/sup&gt;, Ruhainee Tohkayomatee&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomy, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enkhmaa Gonchig</style></author><author><style face="normal" font="default" size="100%">Chimgee Tserendash</style></author><author><style face="normal" font="default" size="100%">Maral-Erdene Gerelt-Od</style></author><author><style face="normal" font="default" size="100%">Batdavaa Batbayar</style></author><author><style face="normal" font="default" size="100%">Mend-Amar Batbaatar</style></author><author><style face="normal" font="default" size="100%">Perleidulam Bunddulam</style></author><author><style face="normal" font="default" size="100%">Enerel Yeruult</style></author><author><style face="normal" font="default" size="100%">Narankhajid Myadagsuren</style></author><author><style face="normal" font="default" size="100%">Otgonbat Altangerel</style></author><author><style face="normal" font="default" size="100%">Yeruult Chultemsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preclinical Safety Assessment of a Polyherbal Formulation: Acute, Subchronic, and Mutagenic Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute toxicity; mutagenicity; phytochemicals; polyherbal formulation; safety evaluation; subchronic toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">322-328</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Before market approval, novel herbal medicines and bioactive compounds require rigorous genotoxicity and safety evaluations. A polyherbal formulation derived from &lt;em&gt;Dasiphora fruticosa, Cynara scolymus&lt;/em&gt;, and &lt;em&gt;Rosa acicularis&lt;/em&gt; has previously demonstrated antioxidant and nephroprotective properties. However, comprehensive toxicological and mutagenicity evaluations are needed to support its clinical development. In this study, we aimed to evaluate the acute and subchronic toxicities and mutagenic potential of this polyherbal formulation.&lt;strong&gt; Methods: &lt;/strong&gt;Acute oral toxicity was assessed in C57BL/6 mice using a two-phase protocol based on Lorke's method. Subchronic toxicity was evaluated in Wistar rats following OECD guideline 407, with daily oral administration of the polyherbal formulation at doses of 500 and 1,000 mg/kg for 28 days. Mutagenicity was assessed using the Muta-Chromoplate (Ames test) kit according to OECD guideline 471. &lt;strong&gt;Results: &lt;/strong&gt;Acute toxicity evaluation determined that the median lethal dose (LD&lt;sub&gt;50&lt;/sub&gt;) of the polyherbal formulation exceeds 5,000 mg/kg, categorising it as practically nontoxic. The subchronic toxicity assessment revealed that doses of 500 and 1,000 mg/kg had no significant effects on body and organ weight, haematological and biochemical parameters, and histopathological features compared with the controls. Furthermore, the Ames test confirmed that the polyherbal formulation had no mutagenic activity. &lt;strong&gt;Conclusions:&lt;/strong&gt; The polyherbal formulation exhibited no acute toxicity at doses up to 5,000 mg/kg, and no adverse effects were observed in a 28-day subchronic toxicity study. Furthermore, its favourable safety profile was further confirmed by its lack of mutagenic potential. Collectively, these findings provide a robust foundation for continued preclinical and clinical development of the polyherbal formulation&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">322</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enkhmaa Gonchig&lt;sup&gt;1&lt;/sup&gt;, Chimgee Tserendash&lt;sup&gt;1&lt;/sup&gt;, Maral-Erdene Gerelt-Od&lt;sup&gt;1&lt;/sup&gt;, Batdavaa Batbayar&lt;sup&gt;1&lt;/sup&gt;, Mend-Amar Batbaatar&lt;sup&gt;1&lt;/sup&gt;, Perleidulam Bunddulam&lt;sup&gt;2&lt;/sup&gt;, Enerel Yeruult&lt;sup&gt;2&lt;/sup&gt;, Narankhajid Myadagsuren&lt;sup&gt;3&lt;/sup&gt;, Otgonbat Altangerel&lt;sup&gt;4*&lt;/sup&gt;, Yeruult Chultemsuren&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, School of Biomedicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Regional Innovation and Social Design Engineering, Kitami Institute of Technology, Hokkaido 090-8507, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Hematology, School of Medicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andi Yulyana Mulmaharani</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Executive and Legislative Behavior in Planning the Stunting Program in Maros District</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Executive</style></keyword><keyword><style  face="normal" font="default" size="100%">Legislative</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural conditions</style></keyword><keyword><style  face="normal" font="default" size="100%">Strategy</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">851-859</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Indonesia has quite a serious nutritional problem which is characterized by the large number of cases of malnutrition in children under five, as a result this problem has become the attention of the Indonesian government so that it has become a national protas called stunting, so it must be resolved in an integrated manner across sectors. Unfortunately, this problem has not been resolved so stunting cases are still very high, one of which is Maros district which has the eighth number of stunting cases based on SSGI data for 2022. &lt;strong&gt;Method:&lt;/strong&gt; Qualitative research is carried out in natural settings to seek information from executive and legislative experience based on knowledge, attitudes, actions and interests. We used indepth interviews, assisted by interview guides, and reviewed the rules to answer the research objectives. The researchers carried out a review of the regulations in the form of basic reading of the recommendations and outreach carried out by the relevant government. &lt;strong&gt;Results:&lt;/strong&gt; Interestingly, government planning uses new methods, namely bottom up, participatory and top down. The reason given by the executive is that this method is the most effective method in government organizations because planning is made based on the Maros district government budget calendar. &lt;strong&gt;Conclusion:&lt;/strong&gt; In analyzing the behavior of the Executive and the legislature, not all of them understand stunting program planning so their involvement is lacking and not all of them play an active role in the stunting program, even though they have an interest in improving the level of health in the people of Maros district by trying to achieve zero stunting for the sustainability of regional development in Maros district. &lt;strong&gt;Recommendation: &lt;/strong&gt;Continuing research on the theme of Analysis of Community Behavior towards the Implementation of Stunting Program Planning in Maros Regency, we suggest to the regional government to accelerate the realization of community welfare through improving human resource services and health levels, overcoming poverty.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">851</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Andi Yulyana Mulmaharani&lt;sup&gt;1*&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Indar&lt;sup&gt;2&lt;/sup&gt;, Darmawansyah&lt;sup&gt;2&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;3&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master of Public Health Program, University Faculty of Public Health Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor of Health Administration and Policy, University Faculty of Public Health Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor of Nutrition Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor of Occupational Safety and Health, Faculty of Public Health, University Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Widya Firly Novitasari</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author><author><style face="normal" font="default" size="100%">Mia Ratwita Andarsini</style></author><author><style face="normal" font="default" size="100%">Betty Agustina Tambunan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Hepcidin and Interleukin-6 Levels among Transfusion-Dependent Thalassemia Patients With and Without Alloimmunization/Autoimmunization</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibodies</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepcidin</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Transfusion-Dependent Thalassemia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">60-66</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Transfusion-dependent thalassemia (TDT) necessitates regular transfusions, resulting in complications such as iron overload, hemolytic anemia, and the emergence of alloantibodies/ autoantibodies. This situation poses challenges in obtaining compatible transfusions. Excessive iron and chronic hemolysis impact the elevation of Interleukin-6 (IL-6), initiating an inflammatory process that triggers hepcidin formation and influences antibody development. This study aims to analyze disparities in IL-6 and hepcidin levels and establish the correlation between IL-6 and hepcidin in TDT patients with and without alloimmunization/autoimmunization.&lt;strong&gt; Methods:&lt;/strong&gt; Forty whole blood samples were collected from TDT patients with and without alloimmunization/autoimmunization, centrifuged, and the serum extracted, then stored in a refrigerator at -80°C. IL-6 and hepcidin levels were assessed using the ELISA method. The Mann-Whitney U test was employed to evaluate differences in hepcidin and IL-6 levels between the two groups. In contrast, the Spearman Correlation test was utilized to analyze the correlation between hepcidin and IL-6 levels. &lt;strong&gt;Results:&lt;/strong&gt; IL-6 levels in the TDT group with alloimmunization/autoimmunization (3.64 pg/ mL) were significantly higher compared to the TDT group without alloimmunization/autoimmunization (1.41 pg/mL; p &amp;lt; 0.05). Hepcidin levels in the TDT group with alloimmunization/autoimmunization (2,950.6 pg/mL) were significantly higher compared to the TDT group without alloimmunization/autoimmunization (1,599.6 pg/mL; p &amp;lt; 0.05). The Spearman correlation test revealed a significant positive correlation between hepcidin and IL-6 levels in TDT patients with alloimmunization/autoimmunization (r = 0.764; p = 0.000). Additionally, a significant positive correlation was observed between hepcidin and IL-6 levels in TDT patients without alloimmunization/autoimmunization (r = 0.559; p = 0.010). &lt;strong&gt;Conclusion:&lt;/strong&gt; IL-6 and hepcidin levels were elevated in TDT patients with alloimmunization/autoimmunization compared to those without. Interleukin-6 and hepcidin exhibited a positive correlation in both transfusion-dependent thalassemia groups.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">60</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Widya Firly Novitasari&lt;sup&gt;1&lt;/sup&gt;, Jusak Nugraha&lt;sup&gt;2&lt;/sup&gt;, Mia Ratwita Andarsini&lt;sup&gt;3&lt;/sup&gt;, Betty Agustina Tambunan&lt;sup&gt;2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Clinical Pathology Specialist Medicine Academic Program, Departement of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pediatrics, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Evawati</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Sudirman Natsir</style></author><author><style face="normal" font="default" size="100%">Razak Thaha</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Lucy Widiasari</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Giving of Mp-Asi Through Food Based on Majene's Local Wisdom for Stunting Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Food based Local</style></keyword><keyword><style  face="normal" font="default" size="100%">MP-ASI</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting Prevention</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Majene Society own tradition and knowledge typical in selecting, processing, and consuming food. Use food local can maintain diversity food and culture local. Food local has proven effective for growth baby optimally. &lt;strong&gt;Goals:&lt;/strong&gt; With do comprehensive analysis to provision of MP-ASI through foodbased wisdom local Majene, expected can an effective and sustainable stunting prevention program was developed.&lt;strong&gt; Method: &lt;/strong&gt;Method research used is study qualitative with design phenomenology. Informant in study This are 103 Baduta mothers who are exclusively breastfed, and live in rural districts Pamboang and District Tameroddo. Data analyzed use content analysis through N-Vivo 12 app. &lt;strong&gt;Results:&lt;/strong&gt; Food tree chief in Tameroddo is rice red Because rice red become plant lots of fields found and easy grows in mountainous areas. Meanwhile in the Coastal Region Pamboang Still consistent with rice white or yams. Typical vegetables is leaf moringa, Langurru ', and Lallere '. Government Regency Majene push planting leaf moringa in each home easy get and help in increase continuity food, savings cost, and independence food in Majene. Besides That, leaf moringa of course known known as &quot; tree magic &quot; because mark high nutrition. Majene Society own access and consumption vegetables langngurru ' and lallere ' are just that found in the area mountains Tameroddo. Usually leaf This used as plant medicine, but in this area made as processed vegetables with add mango sour. Side dish typical Majene known with called &quot; Baupapi &quot;. Habit consumption child given Eat with Fish sauce is considered Already enough , even often this fish sauce considered as replacement vegetables , though very easy found various the main fish species in the coastal area Pamboang . Known Pineapple in local language Majene as “Pandeng” is easiest fruit found Because grow with flourish in the yards House citizen. Findings food local the has content test nutrition and recipe test so that can used as the proper MP-ASI menu for given to baby for optimal growth. &lt;strong&gt;Conclusions and Suggestions:&lt;/strong&gt; Important For ensure that kids get too consumption of fish or other protein sources as well as nutrition from vegetables and sources food other. Order child get appropriate nutrition through provision of adequate MP-ASI. Recommended to nanny , power health and government regency Majene to encourage provision of local MP-ASI with still notice mark appropriate nutrition , MP -ASI module as research output This can used as guidelines Proper provision of MP-ASI .&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Evawati&lt;sup&gt;1,*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;2&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;2&lt;/sup&gt;, Sudirman Natsir&lt;sup&gt;3&lt;/sup&gt;, Razak Thaha&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Lucy Widiasari&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Student, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Nutrition Department, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Health Promotion, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Epidemiology, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suparno</style></author><author><style face="normal" font="default" size="100%">Muhammad Alwy Arifin</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Ida Leida</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Implementation of the Use of Hospital Management Information Systems (Simrs) in Hospitals Kindergarten IV Dr Sumantri Parepare</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hospital</style></keyword><keyword><style  face="normal" font="default" size="100%">Management</style></keyword><keyword><style  face="normal" font="default" size="100%">Reporting</style></keyword><keyword><style  face="normal" font="default" size="100%">SIMRS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">888-894</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; TK Hospital management information system . IV DR Sumantri Parepare is not yet fully integrated and SIMRS must be developed to meet the criteria. &lt;strong&gt;Objective:&lt;/strong&gt; This research aims to analyze the use of the Hospital Management Information System (SIMRS) at TK Hospital. IV DR. Sumantri Parepare, Parepare City. &lt;strong&gt;Method: &lt;/strong&gt;The type of research used in this research is qualitative research and data collection using interviews, observation, documentation. With key informants and supporting informants using purposive sampling techniques. &lt;strong&gt;Results&lt;/strong&gt;: The research results show that in terms of HR input the number of officers is sufficient and training has been given to officers regarding SIMRS, there are funds available, the availability of computers is not sufficient, SIMRS is not yet integrated , the infrastructure inadequate , inadequate implementation of SOPs and socialization Not yet done. The ability of medical records staff to use SIMRS is not optimal , there is incompleteness in filling out medical resumes and informed consent in SIMRS and reporting is carried out every month, quarterly and annually, but experiences delays. &lt;strong&gt;Conclusion:&lt;/strong&gt; Improvement efforts that can be made include disseminating information about the importance or benefits of SIMRS in backing up and searching for data that is entered routinely.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">888</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suparno&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Alwy Arifin&lt;sup&gt;2&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Darmawansyah&lt;sup&gt;2&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;3&lt;/sup&gt;, Ida Leida&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master's Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Health Administration and Policy, Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of epidemiology, Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urmila M Aswar</style></author><author><style face="normal" font="default" size="100%">Savita R. Nimse</style></author><author><style face="normal" font="default" size="100%">Prasad A. Thakurdesai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Androgenic Efficacy and Mechanism of Glycosides-Based  Standardized Fenugreek Seeds Extract Through Aromatase And  5-Alpha Reductase Inhibition</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Androgenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Fenugreek extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">Sexual Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">09-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Fenugreek seeds glycosides content have many health benefits. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the androgenic efficacy and probable mechanism of glycosides-based standardized fenugreek seed extract (SFSE-G) in laboratory rats. &lt;strong&gt;Methods:&lt;/strong&gt; Male Wistar rats were administrated with 28-days of once-daily oral administration of SFSE-G (10 or 35 mg/kg) on sexual and orientational behavior with female rats, serum testosterone concentrations, weights of reproductive system-related organs (seminal vesicles, prostate, levator ani), nitric oxide level in penis homogenate, sperm count in the cauda epididymis, and testis histology were evaluated. Separate groups of rats with a positive control (testosterone propionate (10 mg/ kg, s.c. bi-weekly) and vehicle control (distilled water) were maintained. In addition, the safety of acute intravenous administration of SFSE-G (1 mg/kg) on cardiovascular function parameters was evaluated. Moreover, the inhibitory potential of SFSE-G against aromatase and 5-alpha-reductase enzymes was evaluated in vitro. &lt;strong&gt;Results:&lt;/strong&gt; Subacute administration of SFSE-G (35 mg/kg, oral) to male rats showed androgenic efficacy in sexual behavior (increased mounting and intromission latency and rearing), with increased weights of seminal vehicles, prostate and levator ani muscles, serum testosterone levels, sperm count, and penile NO concentration, while preserving the normal architecture of the testes. Acute intravenous administration of SFSE-G to rats increased intracavernous pressure but retained normal cardiovascular parameters, such as blood pressure, heart rate, and corrected QT interval (QTc). SFSE-G showed significant inhibition of aromatase and 5-alpha-reductase in vitro. &lt;strong&gt;Conclusion:&lt;/strong&gt; SFFE-G exhibited significant androgenic and spermatogenic efficacy, mediated through testosterone metabolism inhibition, without affecting the cardiovascular system in laboratory rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">09</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urmila M Aswar&lt;sup&gt;1&lt;/sup&gt;, Savita R. Nimse&lt;sup&gt;2&lt;/sup&gt;, Prasad A. Thakurdesai&lt;sup&gt;2&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Scientific affairs, Indus Biotech Limited, 1, Rahul Residency, Off Salunke Vihar Road, Kondhwa, Pune 411048, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahwan Ahmad</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">A.Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Stang Stang</style></author><author><style face="normal" font="default" size="100%">Hasanuddin Ishak</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Potential of Durian (Durio zibethinus murr.) Waste as an Alternative Disinfectant in Raw Drinking Water - A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">255-262</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Efforts continue to be made to eliminate pathogenic bacteria in drinking water by using safer disinfection materials. The use of local plants as disinfection materials is highly desirable. The durian plant (Durio zibethinus) can be a very promising alternative as a natural disinfection agent to destroy pathogenic bacteria in drinking water. This narrative review comes from three online journal databases that provide free journal articles in PDF format, collected over the last ten years. The main keywords in conducting a literature review through online journals are &quot;Durian, Durio Zibethinus, antibacterial, disinfectant, drinking water&quot;. Of the 5,693 journals identified in the three databases, 21 studies remained that met the requirements for inclusion in this review. This included study illustrates that fruit rind, seed, and leaf extracts from the durian plant have antimicrobial properties. Durian plants have antibacterial active compounds such as phenolics, alkaloids, steroids, saponins, tannins, flavonoids and triterpenoids. The antimicrobial potential tested using the diffusion and dilution method indicated that the presence of antimicrobial ingredients in the durian plant extraction was in the strong category. Some pathogenic bacteria in water that can be inhibited or killed are Escherichia coli, Pseudomonas aerugenosa, Bacillus subtilis, Bacillus cereus, Enterococcus faecalis, Staphilococcus aureus, Shigella boydii and Salmonella Typhi. This shows that there is an opportunity for the durian plant to provide a solution and great hope as a safe and economical alternative disinfection material as a replacement for current disinfection materials. Index terms: Durian (Durio zibethinus), antibacterial, disinfectant, drinking water.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">255</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahwan Ahmad&lt;sup&gt;1,&lt;/sup&gt;*, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, A.Arsunan Arsin&lt;sup&gt;2&lt;/sup&gt;, Stang Stang&lt;sup&gt;3&lt;/sup&gt;, Hasanuddin Ishak&lt;sup&gt;4&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, School of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laila Tsaqilah</style></author><author><style face="normal" font="default" size="100%">Annisa Febrieza Zulkarnaen</style></author><author><style face="normal" font="default" size="100%">Hartati Purbo Dharmadji</style></author><author><style face="normal" font="default" size="100%">Risa Miliawati Nurul Hidayah</style></author><author><style face="normal" font="default" size="100%">Erda Avriyanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Case Report: High Dose Systemic Corticosteroids as the Therapy for Severe Case Impetigo Herpetiformis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Impetigo herpetiformis</style></keyword><keyword><style  face="normal" font="default" size="100%">Prednisolone</style></keyword><keyword><style  face="normal" font="default" size="100%">Pustular Psoriasis of Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">498-502</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Impetigo herpetiformis (IH) is a rare but life-threatening dermatosis of pregnancy. Early recognition and treatment of IH is important because it may cause maternal and fetal morbidity and mortality. Systemic corticosteroids remain the mainstay of treatment for IH and are considered safe for pregnancy. The purpose of this study was to present successful high-dose corticosteroids as a therapy for severe cases of IH. &lt;strong&gt;Case:&lt;/strong&gt; We reported a 34-year-old pregnant woman in third trimester of pregnancy with a two-week history of reddish patches and pustules spread almost all over her body. She had a history of the same complaint in her latest pregnancy. The diagnosis of severe IH was made based on clinical, laboratory, and histopathology findings. She was prescribed 80 mg/day of oral prednisolone. The eruption and systemic symptoms gradually improved after 12 weeks of treatment. The dose was maintained until delivery before tapered gradually and stopped. The baby was born healthy, and there were not any new lesions. &lt;strong&gt;Discussion:&lt;/strong&gt; Given the possibility of fetal and maternal complications that are potentially lifethreatening, IH needs to be detected and treated right away. The mainstay of treatment for IH is systemic corticosteroids. Steroids control the eruption by preventing polymorphonuclear cells from migrating. Due to its limited placental transmission, prednisolone is regarded to be safe for uses during pregnancy. After 12 weeks of treatment of 80 mg daily prednisolone, the eruptions were resolved and there were not any side effects of steroid observed in both the mother and the baby. &lt;strong&gt;Conclusion:&lt;/strong&gt; Impetigo herpetiformis not only needs early treatment to prevent maternal and fetal complications but also the safety of the treatment chosen. High-dose oral prednisolone is considered effective and safe to control a severe case of IH as it has low placental transmission.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">498</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laila Tsaqilah*, Annisa Febrieza Zulkarnaen, Hartati Purbo Dharmadji, Risa Miliawati Nurul Hidayah, Erda Avriyanti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran- Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bayu Aditya Nugraha</style></author><author><style face="normal" font="default" size="100%">Brahmana Askandar Tjokroprawiro</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinicopathological Analysis of Mucinous Ovarian Tumors at a Single Center in Indonesia, 2019-2023</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinicopathological characteristics</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Mucinous ovarian tumors</style></keyword><keyword><style  face="normal" font="default" size="100%">Single center</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1138-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Mucinous ovarian tumors are a rare subtype of epithelial ovarian tumors, accounting for approximately 3% of all cases. These tumors exhibit unique clinical and pathological characteristics, with a particularly poor prognosis in advanced stages due to low responsiveness to platinum-based chemotherapy. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to analyze the relationships between clinicopathological characteristics in patients with mucinous ovarian tumors treated at a single center in Indonesia between 2019 and 2023. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A correlational study from March to June 2024 analyzed patients with confirmed mucinous ovarian tumors in Indonesia, focusing on age, histopathological grade, FIGO stage, CA-125 levels, tumor size, and metastasis presence. &lt;strong&gt;Results&lt;/strong&gt;: A study of 123 mucinous ovarian tumor patients found that 57.7% were over 40. Histopathological analysis revealed 21.1% were benign, 26% borderline, and 52.8% malignant. Patients over 40 had more malignant tumors, advanced-stage disease, and omental metastasis. A significant correlation was found between malignant histopathology and advanced FIGO stage, as well as between advanced FIGO stage and both lymph node and omental metastasis. Tumor size was associated with elevated CA-125 levels and bilateral tumors. &lt;strong&gt;Conclusion: &lt;/strong&gt;Mucinous ovarian tumors in patients over 40 years old are more likely to be malignant, present at an advanced stage, and involve omental metastasis. Malignant histopathological results are associated with advanced FIGO stages, which in turn are linked to lymph node and omental metastasis. Tumors larger than 10 cm tend to have elevated CA-125 levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1138</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bayu Aditya Nugraha&lt;sup&gt;1&lt;/sup&gt;, Brahmana Askandar Tjokroprawiro&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Resident of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Magdalena Paunno</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Masni</style></author><author><style face="normal" font="default" size="100%">Mardiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Bertha Jean Que</style></author><author><style face="normal" font="default" size="100%">Ridwan Thaha</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determinants of Adverse Birth Outcomes in Ambon, Indonesia: A Case-Control Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">410-414</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Globally, adverse birth outcomes were still high, especially in low and middle-income countries like Indonesia. Stillbirth, preterm birth (PTB), low birth weight (LBW), and first-minute birth asphyxia are some of the adverse birth outcomes. The incidence of adverse birth in Ambon is quite high but never been any research about determinants of adverse birth outcomes. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to examine the determinants of adverse birth outcomes and identify the main modifiable risk factors in Ambon. Method: This retrospective case-control study included all birth outcomes in August and September 2023 in Ambon, Indonesia. A total of 165 birth outcomes (55 cases and 110 controls) with complete information in Puskesmas and Posyandu were included in the analysis. The Chi-square test and regression analyses were applied to evaluate the association between variables. &lt;strong&gt;Result: &lt;/strong&gt;This study showed the impact of pregnant women's age, parity, passive smoking, ANC examination, and ANC counseling on birth outcomes. There are differences in maternal age (p=0.006; 95% CI: 1.22-6.11), parity (p=0.001; 95% CI: 1.52-8.51), passive smokers (p=0.004; 95% CI: 1.37-8.99, ANC examination (p=0.02; 95% CI: 1.08-5.01) and ANC counseling (p=0.002; 95% CI: 1.44-8.67) between case and control groups. &lt;strong&gt;Conclusion: &lt;/strong&gt;Maternal age (≤ 20 and &amp;gt;35 years old), parity (one and ≥ 5), passive smokers, ANC examination not according to standard, and ANC counseling without a husband were associated with a high risk of all adverse birth outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">410</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Magdalena Paunno&lt;sup&gt;1,*&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, Masni&lt;sup&gt;3&lt;/sup&gt;, Mardiana Ahmad&lt;sup&gt;4&lt;/sup&gt;, Bertha Jean Que&lt;sup&gt;5&lt;/sup&gt;, Ridwan Thaha&lt;sup&gt;6&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;6&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Doctor of Public Health Sciences, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department Reproductive Health and Family, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Midwifery, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Medical Faculty, Universitas Pattimura, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasad Thakurdesai</style></author><author><style face="normal" font="default" size="100%">Pallavi Deshpande</style></author><author><style face="normal" font="default" size="100%">Namrata Desai</style></author><author><style face="normal" font="default" size="100%">Prasanna Mathad</style></author><author><style face="normal" font="default" size="100%">Sandhya Rani</style></author><author><style face="normal" font="default" size="100%">Dhananjay Raje</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Double-blind, Randomized Controlled Study of Triterpenoids based Standardized Gotu Kola Leaves Extract in the Patients with Tension Type Headache</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Centella asiatica leaves; Chronic Stress; Pain; Work productivity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1238-1251</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Triterpenoid-based standardized &lt;em&gt;Centella asiatica&lt;/em&gt; leaves extract as nasal solution (INDCANS) has shown potential in animal models of stress-related disorders. &lt;strong&gt;Objective:&lt;/strong&gt; Efficacy and safety evaluation of INDCA-NS in patients with Tension-type headache (TTH). &lt;strong&gt;Methods: &lt;/strong&gt;Ninety-one patients with TTH were randomized and administered INDCA-NS (46 patients) or PLACEBOCA-NS (45 patients) nasal spray (400 μg/day, 100 μg in 100 μL shot/ nostril, twice daily) for 28 days, with a 14-day follow-up. Efficacy (headache duration, frequency, and intensity; 21-item “Depression, Anxiety, and Stress Scale” (DASS-21); “Work Productivity and Activity Questionnaire” (WPAI: SHP); “World Health Organization Brief” (WHOQOL-BREF), cortisol and DHEA levels, rescue medications), and safety outcome measures (including adverse events) were monitored.&lt;strong&gt; Results: &lt;/strong&gt;Subacute administration of INDCA-NS (but not PLACEBOCA-NS) significantly reduced the duration of headache and TTH's effect of TTH on WPAI:SHP (Q5) scores, namely productivity in working patients (P &amp;lt; 0.05, within the groups). The INDCA-NS showed significant difference (P &amp;lt; 0.05) in headache duration with and without covariate adjustment (vs. PLACEBOCA-NS). Both treatments found safe, well- tolerated, with no treatment-related adverse events, significantly reduced headache frequency, pain intensity, DASS-21 (stress domain), TTH's impact on daily activities (Q6 of WPAI:SHP), and improved WHOQOL scores (P &amp;lt; 0.05, within the group). The other outcome measures were not statistically significant within or between groups. &lt;strong&gt;Conclusion: &lt;/strong&gt;Subacute INDCA-NS reduced headache duration and improved work productivity in TTH patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1238</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasad Thakurdesai*, Pallavi Deshpande, Namrata Desai, Prasanna Mathad , Sandhya Rani, Dhananjay Raje&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lina Fitriani</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Masyitha Muis</style></author><author><style face="normal" font="default" size="100%">Nurpudji Astuti Taslim</style></author><author><style face="normal" font="default" size="100%">Sri Sumarni</style></author><author><style face="normal" font="default" size="100%">M.Bambang Uswatul Firdaus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Moringa Oleifera Plus Royal Jelly Capsules in The Gestation Age and Placenta Weight of Newborns in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adverse Birth Outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1177-1182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The incidence of adverse birth outcomes (ABO) in low- and middle-income countries (LIMC) remains significantly elevated. Moringa oleifera (MO), rich nutritional profile, offers to reduce ABO. Therefore, this study aimed to evaluate the impact of MO plus royal jelly capsules on the gestational age and placental weight of newborns in Indonesia. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A quasi-experimental design setup in the Banggai district, Central Sulawesi Province. The study used a purposive sampling of 80 pregnant women from each sub-district. Moilong District received MRJ, while South Batui District was the Multiple Micronutrient Supplement (MMS) control group. Both groups took one capsule daily for six months. Data analysis using SPSS v28 for Windows, including Chi-square/Fisher's exact test, Kolmogorov- Smirnov test, Mann-Whitney test, and ANCOVA, with a significance level of p &amp;lt; 0.05. &lt;strong&gt;Results: &lt;/strong&gt;The demographic characteristics in both groups were similar (p &amp;gt; 0.05), except for BMI (p=0.031). Pregnancy outcomes data were also identical (p &amp;gt; 0.05). The Mann-Whitney test did not show a significant difference (p = 0.696) in the gestational age of delivery between the groups. However, there was a significant difference (p &amp;lt; 0.05) in the PW variable within the MRJ group, as shown by the Mann-Whitney test. After adjusting for BMI in PW, the ANCOVA test indicated a significant difference (p = 0.001).&lt;em&gt; Conclusions: &lt;/em&gt;The study concludes that MRJ and MMS interventions are effective and safe in preventing ABO in newborns based on gestational age and placental weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lina Fitriani&lt;sup&gt;1,2*&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Masyitha Muis&lt;sup&gt;5&lt;/sup&gt;, Nurpudji Astuti Taslim&lt;sup&gt;6&lt;/sup&gt;, Sri Sumarni&lt;sup&gt;7&lt;/sup&gt;, M.Bambang Uswatul Firdaus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Health, Mega Buana University, Palopo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Sciences, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Midicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Acce Basri</style></author><author><style face="normal" font="default" size="100%">Syamsiar Russeng</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Masni Masni</style></author><author><style face="normal" font="default" size="100%">Muhammad Safar</style></author><author><style face="normal" font="default" size="100%">Siti Muslimatun</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of ADCES7 Self Care Behavior Application and Acupressure on Changes in Blood Glucose Levels in Obesive, Prediabetic Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acupressure</style></keyword><keyword><style  face="normal" font="default" size="100%">ADCES7 Self Care Behavior.</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Prediabetes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">744-750</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Prediabetes and obesity in women are important health problems today. Appropriate selfmanagement and other methods are needed to overcome this. Objective: To assess the magnitude of the difference in changes in fasting blood glucose levels, before and after carrying out ADCES7 self-care behavior and acupressure. &lt;strong&gt;Method: &lt;/strong&gt;This research is quasi-experimental research. The research design used was the Non-Randomized Pre Test - Post Test Control Group, which gathered obese, prediabetic women in the Kalumata Community Health Center, Siko Community Health Center and Posbindu under the PKK Ternate City through screening by excluding those who had suffered from diabetes mellitus and were pregnant. This group was then divided into the ADCES7 self care behavior intervention group, the acupressure group and the combined ADCES7 self care behavior and acupressure group. Multivariate logistic regression was used to assess changes in fasting blood glucose levels. &lt;strong&gt;Results:&lt;/strong&gt; Respondents in this study were 102 people who were divided into three groups. The results showed that there was an effect of Self Management intervention p(0.016)&amp;lt;0.05, acupressure intervention p(0.032)&amp;lt;0.05, and the combination group of Self Management and Acupressure p(0.011)&amp;lt;0.05 on changes in fasting blood glucose levels in prediabetic obese women. &lt;strong&gt;Conclusion:&lt;/strong&gt; obese prediabetic women who are aware and active in self-management ACDES7 self care behavior and acupressure can reduce blood glucose levels and body weight in obese prediabetic women&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">744</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Acce Basri&lt;sup&gt;1*&lt;/sup&gt;, Syamsiar Russeng&lt;sup&gt;2&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;5&lt;/sup&gt;, Masni Masni&lt;sup&gt;6&lt;/sup&gt;, Muhammad Safar&lt;sup&gt;7&lt;/sup&gt;, Siti Muslimatun&lt;sup&gt;8&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Degree of Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2,&lt;/sup&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Statistics and Demography, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Health Promotion and Behaviour Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Food Science and Nutrition Indonesia International Institute for Life Sciences, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chutharat Saereewat</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Sunyarn Niempoog</style></author><author><style face="normal" font="default" size="100%">Sucharat Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Chuntida Kamalashiran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy and Safety of Traditional Transdermal Patch (Ya-Pok- Dud-Pid) in Primary Knee Osteoarthritis Patients: A Randomized Controlled Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoarthritis of knee</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional</style></keyword><keyword><style  face="normal" font="default" size="100%">Transdermal Patch</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">570-575</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Patients with Knee Osteoarthritis (KOA) have a progressive decline in their social and physical abilities, which affects their quality of life. The Thai Traditional Transdermal Patch (Ya-Pok-Dud- Pid; YP) has been widely used for the treatment of KOA. &lt;strong&gt;Objective:&lt;/strong&gt; To determine the clinical efficacy and safety of YP in comparison with diclofenac gel (DG) for the treatment of KOA.&lt;strong&gt; Methods:&lt;/strong&gt; 74 primary KOA Patients were enrolled and randomly assigned to YP groups or DG groups. The outcomes were assessed the Visual Analog Scale (VAS), Time Up and Go (TUG), Active Knee Flexion (AKF) and Passive Knee Flexion, chair sit and reach, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). &lt;strong&gt;Results:&lt;/strong&gt; YP and DG significantly improved VAS, TUG, AKF, PKF, chair sit and reach, and WOMAC (p &amp;lt; 0.05). Remarkably, YP experienced the same immediate pain relief after day 1 treatment as DG. The VAS scores of the YP group exhibited a significant reduction from 60±11.06 to 38.92±17.76, while DG decreased VAS score from 61.24±17.84 to 39.19±20.05 (p &amp;lt;0.001). However, there was no significant difference between the two treatment groups. For adverse event, skin reaction (rash, itchy, and dry skin) was noted in the YP group because of the participant receiving YP for an extended period. Altogether, YP has a similar effect to diclofenac gel on pain severity and physical function in patients with knee osteoarthritis. &lt;strong&gt;Conclusion:&lt;/strong&gt; YP is recommended as a natural therapeutic agent with efficacy and safety treatment for knee osteoarthritis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">570</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Chutharat Saereewat&lt;sup&gt;1&lt;/sup&gt;, Kusuma Sriyakul1, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Sunyarn Niempoog&lt;sup&gt;2&lt;/sup&gt;, Sucharat Tungsukruthai&lt;sup&gt;3&lt;/sup&gt;, Chuntida Kamalashiran&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Orthopedic, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neni Wahyu Hastuti</style></author><author><style face="normal" font="default" size="100%">Delfitri Munir</style></author><author><style face="normal" font="default" size="100%">Reno Keumalazia Kamarlis</style></author><author><style face="normal" font="default" size="100%">Bintang Yinke Magdalena Sinag</style></author><author><style face="normal" font="default" size="100%">Adang Bachtiar</style></author><author><style face="normal" font="default" size="100%">Farhat</style></author><author><style face="normal" font="default" size="100%">Amira Permatasari Tarigan</style></author><author><style face="normal" font="default" size="100%">Delyuzar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Eosinophil Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atypical mycobacterium</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytology</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">664-667</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Atypical mycobacterium (ATM) is acid fast bacilli not including tuberculosis and may had opportunistic feature in environment either in air or soil. While symptoms of ATM infection may look similar with typical tuberculosis, these specific group of disease were harder to treat and would necessitate longer antibiotics consumption. While PCR may readily available to detect ATM, anatomical pathology method such as biopsy may be a cheaper alternative in low-resource settings to differentiate between atypical and typical mycobacterium infection. &lt;strong&gt;Aim:&lt;/strong&gt; To analyze correlation between eosinophil cells and eosinophil mass with ATM in lymphadenopathy patient. &lt;strong&gt;Methods: &lt;/strong&gt;This study is an analytical observational study with cross-sectional design which aimed to review diagnostic abilities of eosinophil cell and mass to detect ATM. Patient would undergo both PCR as gold standard of diagnosis and cytology biopsy aspiration as comparative diagnostic modalities. Data would be presented from SPSS v. 25. &lt;strong&gt;Results:&lt;/strong&gt; We collected 70 subjects that fulfill inclusion and exclusion criteria. Most samples were dominated by female in relatively young age. There are 37 patients with ATM in which 75,7% patients cytology result shown expression of eosinophil cells and 71,4% patients shown eosinophilic mass. Chi-square test revealed that statistical significance existed between eosinophilic cells with ATM. However, such statistical significance was not found between eosinophilic mass and ATM. &lt;strong&gt;Conclusion:&lt;/strong&gt; Eosinophilic cell can be used as alternative diagnostic modalities in diagnosing ATM. Further studies should further examine pathophysiological correlations and diagnostic power.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">664</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Neni Wahyu Hastuti&lt;sup&gt;1&lt;/sup&gt;*, Delfitri Munir&lt;sup&gt;2&lt;/sup&gt;, Reno Keumalazia Kamarlis&lt;sup&gt;3&lt;/sup&gt;, Bintang Yinke Magdalena Sinaga&lt;sup&gt;4&lt;/sup&gt;, Adang Bachtiar&lt;sup&gt;5&lt;/sup&gt;, Farhat&lt;sup&gt;2&lt;/sup&gt;, Amira Permatasari Tarigan&lt;sup&gt;4&lt;/sup&gt;, Delyuzar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;6&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ear, Nose, Throat, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomical Pathology, dr Zainoel Abidien Hospital, Universitas Syiah Kuala, Banda Aceh, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Policy and Administration, School of Public Health, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rusli Taher</style></author><author><style face="normal" font="default" size="100%">H. Muh. Syafar</style></author><author><style face="normal" font="default" size="100%">A. Indahwaty Sidin</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Oedojo Soedirman</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Andi Armyn Nurdin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploration of Adolescent Knowledge Experiences and Efforts to Identify Interventions on the Use of Digital Technology Information Media to Increase Knowledge related to HIV/AIDS Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HIV/AIDS</style></keyword><keyword><style  face="normal" font="default" size="100%">Intervention Strategy</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Model Development</style></keyword><keyword><style  face="normal" font="default" size="100%">Youth</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1150-1158</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;HIV/AIDS has become a pandemic that worries the world community, especially teenagers because of their lack of understanding in tackling the prevention and spread of HIV/AIDS. One of the things that can be done is to identify interventions in the utilization of digital technology information media. &lt;strong&gt;Purpose:&lt;/strong&gt; This study focuses on exploring the experiences of adolescents in efforts and in identifying interventions using digital technology information media to increase knowledge related to HIV/AIDS prevention.&lt;strong&gt; Methods:&lt;/strong&gt; Qualitative research using interpretive descriptive approach and literature review on teenage students of SMA Negeri 4 (SMA A) and SMK Negeri 6 (SMA B) in Pangkep Regency, Class II and Class III. Sampling using t purposive sampling type of criteria sampling. The number of participants is 20 people and 5 participants who fall into the source triangulation category. Semi-structured interview guidelines with in-depth interviews, FGDs and observations using field notes. &lt;strong&gt;Results: &lt;/strong&gt;There are 4 main themes that are obtained, namely: 1) Lack of youth knowledge about HIV/AIDS; 2) Perception of adolescents' response control towards HIV/AIDS sufferers (ODHA); 3) Work Program in efforts to prevent HIV/AIDS; 4) The needs of adolescents, teachers, health center staff, and the health office regarding plans for developing interventions to increase youth knowledge in efforts to prevent HIV/AIDS. &lt;strong&gt;Conclusion: &lt;/strong&gt;Respondents have inadequate knowledge about HIV/AIDS, show negative attitudes towards PLHIV and are also involved in risky practices that can affect HIV transmission. This shows that the provision of accurate and comprehensive information related to HIV/ AIDS is a component of prevention and control interventions that must be increased so that intervention strategies are needed to alleviate suffering and possibly reduce the negative consequences that may occur.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rusli Taher&lt;sup&gt;1,2*&lt;/sup&gt;, H. Muh. Syafar&lt;sup&gt;3&lt;/sup&gt;, A. Indahwaty Sidin&lt;sup&gt;4&lt;/sup&gt;, Stang&lt;sup&gt;5&lt;/sup&gt;, Oedojo Soedirman&lt;sup&gt;6&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;7&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;8&lt;/sup&gt; , Andi Armyn Nurdin&lt;sup&gt;9&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;10&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Doctoral Student, Public Health Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer in the Nursing Profession Study Program, STIKES Graha Edukasi Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Promoters and Professors of the Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Lecturers in the Department of Hospital Management, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor of the Department of Biostatistics, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Lecturers of the Department of Health Promotion and Behavioral Sciences FKM UNAIR, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Professor of the Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Professor of the Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Lecturers at the Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Professor, Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deviarbi Sakke Tira</style></author><author><style face="normal" font="default" size="100%">Sonyalin Buifena</style></author><author><style face="normal" font="default" size="100%">Sigit Purnawan</style></author><author><style face="normal" font="default" size="100%">Maria Magdalena Dwi Wahyuni</style></author><author><style face="normal" font="default" size="100%">Marni Marni</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Factors Affecting the Occurrence of Diarrhea in Infants Aged 7-14 Months in Puskesmas Alak Kupang City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BBLR</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">Exclusive Breastfeeding and Immunization Status</style></keyword><keyword><style  face="normal" font="default" size="100%">Premature</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">388-392</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Diarrhea is a disease characterized by changes in the consistency of stools to liquid accompanied by an increase in the frequency of defecation more than usual &amp;gt; 3 times / day accompanied by changes, with or without blood and or mucus. Factors that cause diarrheal disease are infections, infections can be caused by bacteria, parasites and viruses. Busy parents often pay less attention to health and the impact of an unhealthy environment. The three children have digestive problems, which are still considered a habit and can be cured without having to go to a health facility. The purpose of this study was to identify and analyze the factors that influence the incidence of diarrheal disease in infants aged 7-12 months at the Alak Health Center, Kupang City. The type of research used is an analytical survey with a case control design. The population in this study was divided into case populations, namely all infants aged 7-12 months totaling 137 infants and controls were infants aged 7-12 months who did not experience diarrhea totaling 8,868 infants. Determination of the size of the control sample using a ratio of 1:1 with the case sample so that the number of control samples is the same as the case sample, namely 37 infants and the total sample is 74 infants. The sampling technique is simple random sampling. Analysis of the data used is the chisquare test. The results showed that there was a significant relationship with a history of premature birth (p-value = 0.015 with an odds ratio = 3.434), low birth weight (p-value = 0.015 with an odds ratio = 4.563), exclusive breastfeeding (p-value = 0.015 with an odds value ratio = 3.434), immunization status (p-value = 0.004 with odds ratio = 4.265) and history of allergies (p-value = 0.004 with odds ratio = 4.083) with the incidence of diarrheal disease at the Alak Health Center, Kupang City. Suggestions that health center health workers need to be able to increase prevention efforts from an early age by approaching the community and providing concrete education related to the incidence of diarrhea.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Deviarbi Sakke Tira&lt;sup&gt;1,*&lt;/sup&gt;, Sonyalin Buifena&lt;sup&gt;1&lt;/sup&gt;, Sigit Purnawan&lt;sup&gt;1&lt;/sup&gt;, Maria Magdalena Dwi Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Marni Marni&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Science, Faculty of Public Health, Nusa Cendana University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siwaporn Praman</style></author><author><style face="normal" font="default" size="100%">Narudol Teerapattarakan</style></author><author><style face="normal" font="default" size="100%">Thaneeya Hawiset</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Garcinia cowa Leaf Ethanolic Extract Induces Vasorelaxation Through eNOS/NO/sGC Pathway, Potassium, and Calcium Channels in Isolated Rat Thoracic Aorta</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ca2+ channel.</style></keyword><keyword><style  face="normal" font="default" size="100%">Endothelium</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa</style></keyword><keyword><style  face="normal" font="default" size="100%">K+ channel</style></keyword><keyword><style  face="normal" font="default" size="100%">Vasorelaxant effect</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">797-804</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Garcinia cowa Roxb. ex Choisy (G. cowa) is used in traditional medicine, both for improvement of blood circulation and indigestion, also as an antipyretic and expectorant. &lt;strong&gt;Objective:&lt;/strong&gt; This study investigated the vasorelaxant effects and possible mechanisms of action of G. cowa leaf ethanolic extract (GCE) on the rat isolated thoracic aorta. &lt;strong&gt;Methods:&lt;/strong&gt; The study examined the effects of GCE on isolated rat thoracic aorta, including both endothelium-intact and endothelium-denuded aortic rings, using an organ bath system. Specific inhibitors were used to evaluate the mechanism involved in GCE-induced vasorelaxation.&lt;strong&gt; Results:&lt;/strong&gt; GCE (0.01–10 mg/mL) relaxed endothelium-intact aortic rings, that had been precontracted with phenylephrine. Removal of the endothelium or pretreatment of endothelium-intact aortic rings with NꞶ-nitro-L-arginine methyl ester (L-NAME), or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), significantly decreased vasorelaxation induced by the GCE. Indomethacin or propranolol had no effect on the GCE-induced relaxation of the endothelium-intact aortic rings. In endothelium-denuded aortic rings, the relaxation effect of GCE was significantly blocked by 4-aminopyridine (4-AP) and tetraethylammonium (TEA) at the maximum dose of GCE, but not by glibenclamide. In Ca&lt;sup&gt;2&lt;/sup&gt;+-free Krebs solution, GCE (5 and 10 mg/mL) significantly inhibited extracellular Ca&lt;sup&gt;2&lt;/sup&gt;+ induced contraction in pre-contracted rings with high KCl levels. &lt;strong&gt;Conclusions:&lt;/strong&gt; These findings suggest that GCE exhibits both an endothelium-dependent, which is mediated by an eNOS/NO/sGC pathway, and an endothelium-independent pathway, which involves KCa and KV channels opening and extracellular Ca&lt;sup&gt;2&lt;/sup&gt;+ influx inhibition. Kaempferol, isovitexin, quercetin, apigenin, luteolin, and amentoflavone might play a role in inducing the vasorelaxant effect of GCE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">797</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siwaporn Praman*, Narudol Teerapattarakan, Thaneeya Hawiset &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;School of Medicine, Mae&amp;nbsp;Fah Luang University, Chiang Rai 57100, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Niluh Suwasanti</style></author><author><style face="normal" font="default" size="100%">Cecilia Putri Tedyanto</style></author><author><style face="normal" font="default" size="100%">Silvia Sutandhio</style></author><author><style face="normal" font="default" size="100%">Teguh Hari Sucipto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Vitro Antiviral Activity of Dried Red Jujube Fruit (Ziziphus jujuba) Ethanol Extract against DENV-2</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue virus</style></keyword><keyword><style  face="normal" font="default" size="100%">DENV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">dried red jujube fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">Ziziphus jujuba</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1047-1050</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Dengue infection has become one of the most important mosquito-borne diseases worldwide and is caused by the dengue virus (DENV). Recently, neither patent drug, phytopharmaceutical medicine, nor standardized herbal medicine has been officially available against DENV. Dried red jujube fruit &lt;em&gt;(Ziziphus jujuba)&lt;/em&gt; ethanol extract has been proven to have an antiviral effect, anti-inflammatory efficacy, and antioxidant properties, which have potential activity against DENV infection. This research was conducted to analyze the antiviral activity of dried red jujube fruit ethanol extract against DENV-2 in vitro. The halfmaximal cytotoxic concentration (CC&lt;sub&gt;50&lt;/sub&gt;) and half-maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) were examined on Vero cells by a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, whereas the halfmaximal effective concentration (EC&lt;sub&gt;50&lt;/sub&gt;) was determined using luminescence assay. The selectivity index (SI) value was determined from the ratio of CC&lt;sub&gt;50&lt;/sub&gt; and EC50. Dried red jujube fruit ethanol extracts inhibited DENV-2 in 24.59%, 22.39%, 17.98%, 14.5%, 6.42%, and 1.28% at 80 μg/mL, 40 μg/mL, 20 μg/mL, 10 μg/ mL, 5 μg/mL, and 2.5 μg/mL, respectively. The extract exhibited antiviral activity against DENV-2, showing a CC&lt;sub&gt;50&lt;/sub&gt; of 67.73 μg/mL, an IC&lt;sub&gt;50&lt;/sub&gt; value of 166.18 μg/mL, and an EC&lt;sub&gt;50&lt;/sub&gt; of 64.87 μg/mL, with an SI of 1.04. The LD&lt;sub&gt;50&lt;/sub&gt; value was 707.95 mg/kg. Dried red jujube fruit ethanol extract could be a potential candidate for developing an antiviral against DENV-2.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1047</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Niluh Suwasanti&lt;sup&gt;1&lt;/sup&gt;, Cecilia Putri Tedyanto&lt;sup&gt;2&lt;/sup&gt;, Silvia Sutandhio&lt;sup&gt;3&lt;/sup&gt;, Teguh Hari Sucipto&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Katolik Widya Mandala Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Assistant, Faculty of Medicine, Universitas Katolik Widya Mandala Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology and Parasitology, Faculty of Medicine, Universitas Katolik Widya Mandala Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dengue Study Group, Institude of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Zaeim Hafez Ahmed</style></author><author><style face="normal" font="default" size="100%">Muhammad Abdelbaeth Hassan Elfiky</style></author><author><style face="normal" font="default" size="100%">Elsayed Elagamy Elsayed Mohamed</style></author><author><style face="normal" font="default" size="100%">Ramadan Hassan Ibrahim Thabet</style></author><author><style face="normal" font="default" size="100%">Ahmed Mohamed Gad Allah</style></author><author><style face="normal" font="default" size="100%">Ahmed Abdrabo Elshenawy Elsisi</style></author><author><style face="normal" font="default" size="100%">Ahmed Abdel Nasser Ahmed Mohamed</style></author><author><style face="normal" font="default" size="100%">Tarek Shikhon</style></author><author><style face="normal" font="default" size="100%">Mostafa Abo-akrab</style></author><author><style face="normal" font="default" size="100%">Sayed A.M.Mahmoud</style></author><author><style face="normal" font="default" size="100%">Mohamed AbdelAziz Doma</style></author><author><style face="normal" font="default" size="100%">Wael Ahmed Mahmoud Khattab</style></author><author><style face="normal" font="default" size="100%">Khaled Saleh Ali Elhamaky</style></author><author><style face="normal" font="default" size="100%">Mohamed El- Salamoni</style></author><author><style face="normal" font="default" size="100%">Fatma Mahmoud Abdelraheem</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ahmad Mohamed Azab</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ahmad Mohamed Azab6</style></author><author><style face="normal" font="default" size="100%">Mohamed E EL-Refaey</style></author><author><style face="normal" font="default" size="100%">Ahmed A. Abd El-Rhman</style></author><author><style face="normal" font="default" size="100%">Ahmed F. Abdel Ghany</style></author><author><style face="normal" font="default" size="100%">Ghada Adel Hegazy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Chamomile Leaves extract in Different Doses on Renal Functions and Diabetic indices in Streptozotocin – Induced Diabetic Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chamomile leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1029-1035</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The prevalence of diabetes among Egyptians is rising. Therefore, there is always a demand for innovative natural medicines. Medicinal plants have long been a significant source in search of novel, effective alternatives for human therapy. Chamomile is one of the most widely used medicinal plants, which may help hyperglycemic patients by lowering blood sugar levels. Objectives: To determine how chamomile extract affects the kidneys when albino male rats with chronic diabetes are induced by streptozotocin (STZ). &lt;strong&gt;Methods:&lt;/strong&gt; The study was conducted in the Al-Azhar Faculty of Medicine (Assiut) pharmacology department animal laboratory. For this investigation, a local strain of fifty adult male albino rats was used as the animal model and weighed 120 to 150 g. In this study, rats were divided into five groups, body weight, and systolic blood pressure was measured, and blood samples were collected for measuring blood glucose and insulin level, HbA1c, Na, K, and renal function tests, and histopathological examination was done. &lt;strong&gt;Results:&lt;/strong&gt; After the study, mean glucose levels, HbA1c, urea, creatinine, K, and systolic blood pressure were significantly decreased in group IV &amp;amp; group V compared to group III. In contrast, body weight serum insulin level and Na increased dramatically in group IV &amp;amp; group V compared to group III.&lt;strong&gt; Conclusion:&lt;/strong&gt; The serum levels of urea and creatinine in diabetic patients may be positively affected by chamomile. Additionally, short-term chamomile uses benefits diabetic individuals by decreasing loss of body weight, lowering HbA1c, and increasing insulin levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1029</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohamed Zaeim Hafez Ahmed&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Abdelbaeth Hassan Elfiky&lt;sup&gt;1&lt;/sup&gt;, Elsayed Elagamy Elsayed Mohamed&lt;sup&gt;2&lt;/sup&gt;, Ramadan Hassan Ibrahim Thabet&lt;sup&gt;2&lt;/sup&gt;, Ahmed Mohamed Gad Allah&lt;sup&gt;3&lt;/sup&gt;, Ahmed Abdrabo Elshenawy Elsisi&lt;sup&gt;2&lt;/sup&gt;, Ahmed Abdel Nasser Ahmed Mohamed&lt;sup&gt;2&lt;/sup&gt;, Tarek Shikhon&lt;sup&gt;4&lt;/sup&gt;, Mostafa Abo-akrab4, Sayed A.M.Mahmoud&lt;sup&gt;5&lt;/sup&gt;, Mohamed AbdelAziz Doma&lt;sup&gt;5&lt;/sup&gt;, Wael Ahmed Mahmoud Khattab&lt;sup&gt;6&lt;/sup&gt;, Khaled Saleh Ali Elhamaky&lt;sup&gt;7&lt;/sup&gt;, Mohamed El-Salamoni&lt;sup&gt;6&lt;/sup&gt;, Fatma Mahmoud Abdelraheem&lt;sup&gt;8,&lt;/sup&gt; Mahmoud Ahmad Mohamed Azab&lt;sup&gt;6&lt;/sup&gt;, Ashraf Abdel Aty Elshenawy Emara&lt;sup&gt;6&lt;/sup&gt;, Mohamed E EL-Refaey&lt;sup&gt;1&lt;/sup&gt;, Ahmed A. Abd El-Rhman&lt;sup&gt;1&lt;/sup&gt;, Ahmed F. Abdel Ghany&lt;sup&gt;1&lt;/sup&gt;, Ghada Adel&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Al-Azhar University (Assiut), Assiut, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carla Y. Requejo-Rodríguez</style></author><author><style face="normal" font="default" size="100%">Elmer M. Roncal-Alayo</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Walter E. Janampa-Castillo</style></author><author><style face="normal" font="default" size="100%">José E. Alvarez- Trujillo</style></author><author><style face="normal" font="default" size="100%">Glenda J. Vela-Urbina</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María E. Cotrina-León</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Deivy Y. Dionicio-Rosado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Juglans regia L.: Source of Bioactive Compounds with Potential Anticancer Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Juglans regia L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">998-1003</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Juglans regia&lt;/em&gt; L., commonly known as “walnut”, belongs to the Juglandaceae family, with antioxidant, anti-inflammatory, and hypoglycemic medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; Describe the anticancer potential of the bioactive compounds present in &lt;em&gt;Juglans regia&lt;/em&gt; L.&lt;strong&gt; Method:&lt;/strong&gt; Recent scientific studies were reviewed on the effects of bioactive compounds from &lt;em&gt;Juglans regia&lt;/em&gt; L. on inhibiting tumor growth and cancer development in several experimental models. To do this, a scientific literature search was carried out, using databases such as PubMed, Scopus, and Science Direct. &lt;strong&gt;Results:&lt;/strong&gt; Regarding the selected articles, it was found that some bioactive compounds from&lt;em&gt; Juglans regia &lt;/em&gt;L. exhibit mechanisms of anticancer action, among which the following stand out: induction of apoptosis, suppression of angiogenesis, and modulation of cell signaling pathways related to cell proliferation and survival. &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that &lt;em&gt;Juglans regia&lt;/em&gt; L. contains active metabolites with potential anticancer effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">998</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carla Y. Requejo-Rodríguez¹, Elmer M. Roncal-Alayo¹, Carmen R. Silva-Correa&lt;sup&gt;2,*&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;2&lt;/sup&gt;, Walter E. Janampa-Castillo&lt;sup&gt;3&lt;/sup&gt;, José E. Alvarez-Trujillo&lt;sup&gt;3&lt;/sup&gt;, Glenda J. Vela-Urbina&lt;sup&gt;3&lt;/sup&gt;, Abhel A. Calderón- Peña&lt;sup&gt;4&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;4&lt;/sup&gt;, María E. Cotrina-León&lt;sup&gt;5&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;5&lt;/sup&gt;, Deivy Y. Dionicio-Rosado&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Posgrado, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Educación y Ciencias de la Comunicación, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Ciencias Sociales y Humanidades, Universidad Nacional Ciro Alegría, Perú&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Librawaty Sara Tangibali</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Ridwan M. Thaha</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Hasanuddin Ishak</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Measuring Adolescent Mental Health and the Effect on Junevile Deliquency Behavior Tendencies. Case Study in Tana Toraja</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent</style></keyword><keyword><style  face="normal" font="default" size="100%">Juneville delinquency tendency</style></keyword><keyword><style  face="normal" font="default" size="100%">Mental health</style></keyword><keyword><style  face="normal" font="default" size="100%">Self-Control</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">231-234</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Adolescence is a transitional phase of development from childhood to adulthood, involving various changes in the biological, cognitive, and socio-emotional aspects of the adolescent. These changes often lead to confusion in establishing their identity, which can result in behaviors that are not in line with their developmental responsibilities. The tendency towards delinquent behavior in adolescents is one of the forms of behavior that emerges during adolescence due to the dysfunction of various aspects within the adolescent. The presence of dysfunction in these aspects of the adolescent indicates that the adolescent is experiencing mental disorders. The aim of this study is to analyze how the mental health of adolescents influences their tendency to engage in delinquent behaviors. &lt;strong&gt;Method: &lt;/strong&gt;Using a quantitative method with descriptive statistics and testing assumptions using multiple linear regression analysis. &lt;strong&gt;Result:&lt;/strong&gt; Based on the characteristics of adolescents aged 14 to 18 years, it was found that the mental health condition of adolescents has an impact on the tendency of delinquent behavior in adolescents, with a value based on the linear regression model of 0.000 &amp;lt; 0.05, indicating a significant level. &lt;strong&gt;Conclusion:&lt;/strong&gt; The non-impulsive behavioral aspect is the most significantly influential factor on the tendency of adolescent delinquent behavior with a value of p &amp;lt; 0.05.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">231</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Librawaty Sara Tangibali&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Syafar&lt;sup&gt;2&lt;/sup&gt;, Ridwan M. Thaha&lt;sup&gt;2&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;2&lt;/sup&gt;, Hasanuddin Ishak&lt;sup&gt;3&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master Program of Department in Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor of Department in Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor of Administration and Health Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Icha Dian Nurcahyani</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Obstacles to the Complementary Feeding Assistance Program for Stunted Children Aged 6-24 Months: A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast milk</style></keyword><keyword><style  face="normal" font="default" size="100%">Complementary Feeding</style></keyword><keyword><style  face="normal" font="default" size="100%">Program Barriers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1209-1217</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Stunting is a condition of stunted physical and cognitive growth caused by malnutrition during the development of children under five. UNICEF and WHO recommendations stipulate exclusive breastfeeding for 6 months and breastfeeding for up to two years. Apart from that, it is very important to provide complementary foods for breast milk for 6-23 months. The aim of the research is to determine the obstacles to the Complementary Feeding assistance program for stunted children aged 6-24 months. The method used is a Systematic Literature Review. Health database with search engines Google Scholar, PubMed, Science Direch, ProQuest and Scinapse. The search strategy uses the keywords: Program Constraints, Complementary Feeding, Stunting and Baduta. Identifying research articles for 2017-2023 and using PRISMA flowcharts and literature eligibility criteria based on the PICOS framework. A total of 10,523 articles were identified. Five articles used cross sectional methods, three survey articles, one descriptive analysis article and one cohort article. There were 10 eligible articles that met the inclusion criteria. Based on the results of the identification of Complementary Feeding assistance programs for stunted children aged 6-24 months. There is a correlation between obstacles to the mentoring program related to non-optimal complementary feeding practices (accuracy, diversity and frequency), lack of knowledge and experience, obstacles in communication skills (delivering key messages), selfefficacy/ working mothers, sanitation/environmental conditions, socio-economic, weak regulations and government programs including increasing community-based programs such as posyandu. If children aged 0-23 months receive inappropriate complementary foods, they are at high risk of stunting. Various obstacles to the Complementary Feeding assistance program will influence the program's emphasis on promoting children's growth and development to prevent stunting. Conclusion: the Complementary Feeding mentoring program is not optimal, due to various obstacles (specific and sensitive) faced in providing Complementary Feeding to stunted children aged 6-23 months.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1209</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Icha Dian Nurcahyani&lt;sup&gt;1,2*&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;4&lt;/sup&gt;, Wahiduddin&lt;sup&gt;3&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;5&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Nutrition Study Program, Salewangang Maros College of Health Sciences, South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Environmental Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nutrition, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mirawati Tongko</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Irwandy</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Maria Kanan</style></author><author><style face="normal" font="default" size="100%">Fahrudin Lahay</style></author><author><style face="normal" font="default" size="100%">Almustari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Occupational Diseases in Female Workers in the Industrial World, Indonesia: Hazard Types and Exposure Mechanisms – Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Female Worker</style></keyword><keyword><style  face="normal" font="default" size="100%">Hazard</style></keyword><keyword><style  face="normal" font="default" size="100%">Industry</style></keyword><keyword><style  face="normal" font="default" size="100%">Occupational Disease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">263-267</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Occupational diseases are diseases caused by work and the work environment. Specifically gender, women have a double burden, namely domestic work in the household and the burden of being a breadwinner who works outside the home, women are also faced with reproductive tasks, namely pregnancy, childbirth and breastfeeding, and bioanatomically women have physical strength different from men, so that women are specifically more vulnerable to health risks due to their work, both physically, mental and social. This research will review the types and mechanisms of the spread of Occupational Diseases (OD) in female workers in the industrial world. &lt;strong&gt;Methods: &lt;/strong&gt;The writing of this research was carried out using the Literature Review method which is a literature review method in which scientific articles are selected by researchers related to the research topic. &lt;strong&gt;Results:&lt;/strong&gt; According to the results of the study, the specific risk of occupational diseases in the female worker community is pregnancy and childbirth disorders, Anemia and Sexuall Transmitted Disease (STD), while other accompanying diseases are Pulmonary Obstruction Disease, Tinea pedis, Neurotoksic Symptoms, Noice Induce Hearing Loss (NIHL), Low Back Pain (LBP), MSDs, and Work Stress. &lt;strong&gt;Conclusion:&lt;/strong&gt; Every female worker has a susceptibility to occupational diseases according to the conditions and work environment experienced. The industry must pay attention to programs to improve occupational health by making anticipatory efforts so that occupational diseases do not become a life threat to female workers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">263</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mirawati Tongko&lt;sup&gt;1,&lt;/sup&gt;*, Yahya Thamrin&lt;sup&gt;1&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;1&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;1&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, Irwandy&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;, Maria Kanan&lt;sup&gt;5&lt;/sup&gt;, Fahrudin Lahay&lt;sup&gt;6&lt;/sup&gt;, Almustari&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Hospital Management and Administration, Faculty of Public Health,&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurjanna</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Syria</style></author><author><style face="normal" font="default" size="100%">Ridwan M. Thaha</style></author><author><style face="normal" font="default" size="100%">Abdul Salam</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Peer Group Empowerment to Improve Teenagers' Behavior in Consuming Blood Supplement Tablets Through the Youth Integrated Healthcare Center Program</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">blood supplement tablets</style></keyword><keyword><style  face="normal" font="default" size="100%">peer groups</style></keyword><keyword><style  face="normal" font="default" size="100%">Teenagers</style></keyword><keyword><style  face="normal" font="default" size="100%">youth Integrated Healthcare Center</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">400-404</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Backgrounds: &lt;/strong&gt;South Sulawesi Province ranks in the top 7 with a percentage of 58.9% coverage of TTD provision to adolescent girls. Based on data from the Gowa District Health Service in 2021, it shows that the number of coverage for taking blood-added tablets among young women is 57% of the accumulated achievements of 26 health centers, where the health center with the lowest number of coverage for taking blood-added tablets is one of the Kanjilo Community Health Centers with an achievement of 18% of 1239 targets targets. Youth Integrated Healthcare Center with a peer-group approach allows for continuous interaction between peer educators and their peers so that the delivery of information is more intensive. This research aims to determine the effect of peer group empowerment to increase adolescent behavior in consuming blood supplement tablets at the Youth Integrated Healthcare Center, Barombong District, Gowa Regency. Methods: This research uses a quantitative method of quasi-experimental design with a pre-test and post-test group approach. The population in this study were all members of the youth Integrated Healthcare Center in the Kanjilo health center working area, Barombong sub-district, South Sulawesi province, who were divided into two groups, namely the intervention group and the control group, each with 40 people. Results: The results of the study showed that there was a significant effect of peer group empowerment intervention on intention, self-efficacy, knowledge, attitudes, parental support, and teacher support in the intervention group and control group in consuming blood supplement tablets in youth Integrated Healthcare Center with a p-value &amp;lt; 0.05. Apart from that, the results showed that adolescent Integrated Healthcare Center participants were more disciplined in consuming blood supplement tablets because of peer invitations which made changes in adolescent behavior in a more positive direction. &lt;strong&gt;Conclusion:&lt;/strong&gt; There is a significant influence between the intervention group and the control group before and after being given counseling and peer group empowerment training on adolescent behavior in consuming blood supplement tablets.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">400</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nurjanna&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;2&lt;/sup&gt;, Syria&lt;sup&gt;2&lt;/sup&gt;, Ridwan M. Thaha&lt;sup&gt;2&lt;/sup&gt;, Abdul Salam&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Master of Health Promotion Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Khemjira Jarmkom</style></author><author><style face="normal" font="default" size="100%">Wanna Eiamart</style></author><author><style face="normal" font="default" size="100%">Prakairat Tunit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antioxidant and Anti-Arthritis Potential of Decoction Extract from Caulerpa lentillifera</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-arthritis activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Caulerpa lentillifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical components</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">927-932</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Caulerpa lentillifera &lt;/em&gt;also known as sea grape, is a green seaweed in the Caulerpaceae family known for its nutritional benefits and medicinal properties. This study aimed to examine the phytochemical compounds, total phenolic content, total flavonoid content, and antioxidant and anti-arthritis properties of sea grape decoction extract. The total phenolic content was measured using the Folin-Ciocalteu method, and the total flavonoid content was determined with the aluminum chloride colorimetric method. Antioxidant activities were evaluated using two methods: 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2’-azinobis-(3- ethylbenzothia-zoline-6-sulfonate) (ABTS). The anti-arthritis activities were assessed using bovine-serum protein. The study identified that the extract contained flavonoids, saponin, terpenoids and coumarins, with the total phenolic content of 343.19 ± 9.86 μg gallic acid equivalents/ mg dry extract and the total flavonoid content of 268.48 ± 16.57 μg quercetin equivalents/ mg dry extract. The extract showed antioxidant activity with an IC&lt;sub&gt;50&lt;/sub&gt; value of 309.05±5.91 μg/ml using the DPPH method and 572.33±3.47 μg/ml using the ABTS method, respectively. Additionally, it exhibited anti-arthritis properties with an IC&lt;sub&gt;50 &lt;/sub&gt;value of 54.60±12.71 μg/ml, which was less than 1.69 times the IC&lt;sub&gt;50 &lt;/sub&gt;value of diclofenac sodium. A strong positive correlation was found between the antioxidant and anti-arthritis activities measured by the ABTS method, with an R² value of 0.9476. Therefore, this study provides initial evidence supporting the antioxidant and anti-arthritis activities of sea grape decoction extract. The extract shows potential for further development as a product for treating arthritis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">927</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Khemjira Jarmkom&lt;sup&gt;1&lt;/sup&gt;, Wanna Eiamart&lt;sup&gt;2&lt;/sup&gt;, Prakairat Tunit&lt;sup&gt;3*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Innovation of Health Products Program, Faculty of Integrative Medicine,&amp;nbsp;Rajamangala University of Technology Thanyaburi, Pathumthani, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Chula&amp;nbsp;Pharmacokinetic Research Center, Faculty of medicine, Chulalongkorn university, Bangkok, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Thai Traditional Medicine Program, Faculty of Nursing and Allied Health Sciences,&amp;nbsp;Phetchaburi Rajabhat University, Phetchaburi, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eva Krishna Sutedja</style></author><author><style face="normal" font="default" size="100%">Frizam Dwindamuldan Sutisna</style></author><author><style face="normal" font="default" size="100%">Endang Sutedja</style></author><author><style face="normal" font="default" size="100%">Kartika Ruchiatan</style></author><author><style face="normal" font="default" size="100%">Yogi Faldian</style></author><author><style face="normal" font="default" size="100%">Laila Tsaqilah</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author><author><style face="normal" font="default" size="100%">Yovan Rivanzah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Poikilodermatous Mycosis Fungoides: A Rare Case Treated with Low-Dose Methotrexate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cutaneous T-cell lymphoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Methotrexate</style></keyword><keyword><style  face="normal" font="default" size="100%">Mycosis fungoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Poikilodermatous mycosis fungoides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">276-279</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Mycosis fungoides (MF) is a subtype of cutaneous T-cell lymphoma (CTCL) and a primary cutaneous lymphoma. Poikilodermatous MF (PMF) is a rare clinical variant of MF. Systemic chemotherapy, such as methotrexate (MTX), may be administered as monotherapy or in combination at low doses in MF. A 64-year-old man with PMF has been reported. History and physical examination revealed hyperpigmented and hypopigmented macules on the chest, abdomen, both arms, back, and upper legs, along with erythematous macules on the right medial thigh. The diagnosis of PMF is based on clinical manifestations and histopathological features of atypical lymphocyte cell infiltration in the epidermis. In addition, immunohistochemical examination also supports the MF diagnosis. The patient received chemotherapy consisting of monotherapy with MTX at low doses. During the third month of observation following MTX therapy, a few of the hyperpigmented and hypopigmented macules appeared to have diminished; some of the erythematous macules had transformed into hyperpigmented macules, and there were no new lesions. The purpose of therapy is to control the disease. Administration of low-dose MTX as a monotherapy may result in clinical improvement, but further observation is necessary. PMF may have a better prognosis than other clinical variants of MF.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eva Krishna Sutedja&lt;sup&gt;1&lt;/sup&gt;*, Frizam Dwindamuldan Sutisna&lt;sup&gt;1&lt;/sup&gt;, Endang Sutedja&lt;sup&gt;1&lt;/sup&gt;, Kartika Ruchiatan&lt;sup&gt;1&lt;/sup&gt;, Yogi Faldian&lt;sup&gt;1&lt;/sup&gt;, Laila Tsaqilah&lt;sup&gt;1&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;2&lt;/sup&gt;, Yovan Rivanzah&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Gusti Agung Ayu Eka Putri Sunari</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Faradila Khoirun Nisa Hakim</style></author><author><style face="normal" font="default" size="100%">May Fanny Tanzilia</style></author><author><style face="normal" font="default" size="100%">Ida Parwati</style></author><author><style face="normal" font="default" size="100%">Rismawati Yaswir</style></author><author><style face="normal" font="default" size="100%">Budi Mulyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Positive NS1 Antigen in Non-Dengue Virus Infection Serum: Possible Reasons for the Discrepancy with DENV PCR Results</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dengue Virus Infection.</style></keyword><keyword><style  face="normal" font="default" size="100%">NS1Ag</style></keyword><keyword><style  face="normal" font="default" size="100%">RT-PCR DENV</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">923-926</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objective: &lt;/strong&gt;A specific examination is required to distinguish between DVI and viral, bacterial, and parasitic illnesses because their clinical manifestations are nearly identical. Leukopenia and lymphocytosis are examples of non-specific tests that might be used to get a diagnosis. Non-structural protein 1 (NS1) antigen, anti-DENV antibody, or DENV-specific nucleic acid detection are more specific assays. &lt;strong&gt;Methods:&lt;/strong&gt; Virus isolation or molecular analysis of the detection of DENV nucleic acid ribonucleic acid (RNA) using RT-PCR was used to make the conclusive diagnosis of DVI. The sensitivity of the DENV RT-PCR method ranges from 28.8 to 99%. NS1 antigen is used as an initial diagnostic option in primary health care because it has a high specificity value (100%). Researchers want to analyze the positivity in non-DVI samples that have been confirmed by real-time RT-PCR examination with semi-quantitative NS1 antigen examination. Patient population aged 1-65 years with acute fever &amp;lt;5 days. A total of 130 samples of non-DVI confirmed patients by RT-PCR were examined for NS1Antigen ELISA. &lt;strong&gt;Results: &lt;/strong&gt;With a proportion of 3.08% of the total sample, the results showed that 4 NS1Antigen ELISA samples were positive. A negative DENV RT-PCR result could indicate either a true negative or a false negative. &lt;strong&gt;Conclusion: &lt;/strong&gt;The type of PCR technology, the primer used, the existence or absence of a DENV mutation, the DENV serotype, and the presence of mismatched nucleotides can all affect variations in DENV PCR sensitivity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">923</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;I Gusti Agung Ayu Eka Putri Sunari&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;1*&lt;/sup&gt;, Faradila Khoirun Nisa Hakim&lt;sup&gt;2&lt;/sup&gt;, May Fanny Tanzilia&lt;sup&gt;3&lt;/sup&gt;, Ida Parwati&lt;sup&gt;4&lt;/sup&gt;, Rismawati Yaswir&lt;sup&gt;5&lt;/sup&gt;, Budi Mulyono&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Airlangga – Dr. Soetomo Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Ciputra, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, IINDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing,&amp;nbsp;Universitas Gadjah Mada - Dr. Sardjito General Hospital, Yogyakarta, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rena Normasari</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Damayanti Tinduh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effects of Rutinoside on Oxidative Induced Articular Cartilage Damage and Catabolic Activity in Rat Chondrocyte</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoarthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Rutinoside</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">360-365</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to look into the therapeutic potential of rutinoside in reducing articular cartilage degeneration in a rat model of osteoarthritis generated by monosodium iodoacetate (MIA). &lt;strong&gt;Methods:&lt;/strong&gt; We formed three groups of male Wistar rats: the OA, rutinoside, and control groups. Monosodium iodoacetate (3.0 mg) was injected intra-articularly into the knee joint to cause osteoarthritis. For four weeks, oral administration of rutinoside at 100 mg/kg/day was given to the groups that were given the treatment. Histological examination, immunohistochemistry, and biochemical tests were used to assess the level of articular cartilage injury, oxidative damage, catabolic activity, and biomarker expression. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that treatments with rutinoside significantly reduced the damage to articular cartilage in rats with MIA-induced osteoarthritis. Compared to the osteoarthritis group, the rutinoside-treated groups showed enhanced cartilage structure, proteoglycan content, and chondrocyte organization. Immunohistochemistry revealed reduced NFκB, IL-1β, and MMP-13 expressions in the rutinosidetreated groups, indicating suppressed inflammatory and catabolic activity in chondrocytes. Additionally, rutinoside treatment increased SOD activity and decreased MDA levels, which showed less oxidative damage to the joint. A substantial drop in CTX-II levels was found by biochemical research, indicating less type II collagen breakdown. &lt;strong&gt;Conclusion: &lt;/strong&gt;According to a study, rutinoside effectively reduces oxidative damage and catabolic activity in chondrocytes, which can lead to decreased articular cartilage loss in a rat model of MIA-induced osteoarthritis. The study also found that rutinoside can control critical biomarkers such as NFκB, IL-1β, SOD, MDA, MMP-13, and CTX-II, highlighting its potential as a treatment for osteoarthritis. These findings provide valuable insights into using natural chemicals as a promising treatment for OA and suggest that rutinoside could potentially modulate the critical interplay between oxidative stress, inflammation, and chondrocyte catabolism in osteoarthritis. However, further research is required to understand the underlying molecular mechanisms and evaluate rutinoside's translational potential for OA therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">360</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rena Normasari&lt;sup&gt;1,2&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;3*&lt;/sup&gt;, Damayanti Tinduh&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Airlangga University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pathology Anatomy Department, Medical Faculty, Jember University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Physiology Department, Faculty of Medicine, Airlangga University, INDONESIA. 4Physical Medicine and Rehabilitation Department, Faculty of Medicine, Airlangga University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Istiana Tadjuddin</style></author><author><style face="normal" font="default" size="100%">Iva Hardi Yanti</style></author><author><style face="normal" font="default" size="100%">Nurul Mawaddah Syafitri</style></author><author><style face="normal" font="default" size="100%">Yulianah Rahmadani</style></author><author><style face="normal" font="default" size="100%">Mahfuddin Yusbud</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Quasi-Experimental One Group Pre-Post Test Design in Air Traffic Controller in Indonesia: Progressive Muscle Relaxation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">638-643</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The effectiveness of progressive muscle relaxation (PMR) in assessing the general health of air traffic controllers (ATC) is still insufficient, specifically when examining the psychological conditions of workers who use questionnaire instruments. Therefore, this research aimed to evaluate the use of PMR program in ATC by developing a model using biomarkers (saliva) tested on the cocorometer stress diagnostic tool and validity, including observing related determinants in the work environment. &lt;strong&gt;Methods:&lt;/strong&gt; A quasi-experimental method was used, focusing on one group pre-post-test design for 92 respondents across six research areas in Indonesia. All respondents had received training in PMR methods conducted by psychologists. Subsequently, ongoing assistance was provided in implementing relaxation by a trained reminder team for eight weeks to maintain the precision and effectiveness of the intervention. Further analysis was conducted using the Wilcoxon signed rank test to evaluate the success of the intervention. &lt;strong&gt;Results:&lt;/strong&gt; The implementation of PMR program in ATC reduced the incidence of stress levels after the observation. Statistically, the feeling of fatigue was a significant variable that decreased in mean value after the implementation of the relaxation program on the data review. The main benefit of PMR program in improving psychological health conditions (stress) was found in Surabaya branch ATC. &lt;strong&gt;Conclusions: &lt;/strong&gt;The relaxation program was proven to reduce stress levels in ATC, showing an improvement in conditions before and after the implementation of PMR.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">638</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Lalu Muhammad Saleh&lt;sup&gt;1&lt;/sup&gt;*, Syamsiar S. Russeng&lt;sup&gt;1&lt;/sup&gt;, Istiana Tadjuddin&lt;sup&gt;2&lt;/sup&gt;, Iva Hardi Yanti&lt;sup&gt;3&lt;/sup&gt;, Nurul Mawaddah Syafitri&lt;sup&gt;1&lt;/sup&gt;, Yulianah Rahmadani&lt;sup&gt;1&lt;/sup&gt;, Mahfuddin Yusbud&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Psychology, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiological, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patnaree Wongmanit</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Ouppatham Supasyndh</style></author><author><style face="normal" font="default" size="100%">Pratya Phetkate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Renal Resistive Index and Estimated Glomerular Filtration Rate in Nondiabetic Chronic Kidney Disease Stage 3: A Cross-Sectional Analytical Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">538-544</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Renal resistive index (RRI) and estimated glomerular filtration rate (eGFR) are predictive markers for chronic kidney disease (CKD) progression. &lt;strong&gt;Aim:&lt;/strong&gt; To evaluate RRI value, eGFRcr-cys and renal biomarker in nondiabetic patients with CKD stage 3 in Bangkok, Thailand. &lt;strong&gt;Methods:&lt;/strong&gt; A cross-sectional analytical analysis was conducted involving nondiabetic patients with CKD stage 3, aged 35-85 years. Ultrasound was used to assess the RRI of arteries in both kidneys. Patients underwent assessments of serum and urine 24-hour. &lt;strong&gt;Results:&lt;/strong&gt; Among the 61 participants (67.2% male; mean age 69.03 ± 12.59 years), the mean eGFRcr-cys was 41.63 ± 8.64 mL/min/1.73 m², and the mean RRI was 0.65 ± 0.06. Patients were categorized into three RRI groups: low (&amp;lt;0.65, n=35), intermediate (0.65-0.70, n=14), and high (&amp;gt;0.70, n=12). The high RRI group showed a mean RRI of 0.73 ± 0.05 (p &amp;lt; 0.01). Among those with high RRI group were significant decreased right kidney size (p&amp;lt;0.05) and they had a lower BMI, averaging 22.49 ± 3.48. An increase in PP (59.66 ± 13.84, p=0.04) was also significant in this group. The correlations coefficient of RRI value showed a significant positive correlation with age (p&amp;lt;0.05) and significant negative with BMI (p&amp;lt;0.05). In addition, eGFRcr-cys displayed a significant negative correlation with UAGT and 24hUP (p&amp;lt;0.05) and a significant while eGFRcr-cys positive correlation with both kidney size and urine iNOS(p&amp;lt;0.01). &lt;strong&gt;Conclusion:&lt;/strong&gt; An increase in RRI is inversely linked to age, BMI, and PP. Lower eGFR is correlated with factors that cause CKD progression.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">538</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Patnaree Wongmanit&lt;sup&gt;1&lt;/sup&gt;, Kusuma Sriyakul&lt;sup&gt;1&lt;/sup&gt;, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Ouppatham Supasyndh&lt;sup&gt;2&lt;/sup&gt;, Sucharat Tungsukruthai&lt;sup&gt;3&lt;/sup&gt;, Pratya Phetkate&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Kasetsart University, Ngamwongwan Rd, Chatuchak, Bangkok 10900, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Piracha Jumpa-ngern</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Chuntida Kamalashiran</style></author><author><style face="normal" font="default" size="100%">Somboon Kietinun</style></author><author><style face="normal" font="default" size="100%">Kesara Na- Bangchang</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Safety Assessment of Oral Lysiphyllum strychnifolium Aqueous Extract in Healthy Volunteers</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Healthy volunteers</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysiphyllum strychnifolium</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword><keyword><style  face="normal" font="default" size="100%">Yanang Daeng</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">235-240</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Lysiphyllum strychnifolium&lt;/em&gt; (LS), widely known as Ya nang daeng in Thailand, is a traditional herbal remedy that has long been used to promote health and treat diverse health conditions, especially detoxification, by alleviating the severity of symptoms and lowering the risks associated with toxic exposures. Although it is extensively used in Thailand, human safety studies have been lacking. Thus, this study aimed to examine the safety of using LS capsules in healthy participants through a Phase I clinical trial. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to investigate the safety of aqueous extract of LS in twenty-four healthy Thai participants. &lt;strong&gt;Method: &lt;/strong&gt;The participants were received 1,000 mg of LS aqueous extract each morning before their meals for seven days. All participants were examined safety assessment including history taking, physical examination, and laboratory tests at day 0, 8 and 14 (follow-up). &lt;strong&gt;Results:&lt;/strong&gt; The findings showed that there were no significant side effects or abnormalities found during the history taking, physical examination, or laboratory evaluation. Particularly, when compared to baseline, participants who received LS experienced statistically significant reductions in blood sugar, triglyceride, LDL cholesterol, and creatinine (P &amp;lt; 0.05), but still within normal ranges. &lt;strong&gt;Conclusions:&lt;/strong&gt; Dietary supplementation with 1,000 mg of LS aqueous extract per day may have a beneficial effect on blood sugar and cholesterol management while remaining safe for healthy people.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">235</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Piracha Jumpa-ngern&lt;sup&gt;1&lt;/sup&gt;, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Chuntida Kamalashiran&lt;sup&gt;1&lt;/sup&gt;, Somboon Kietinun&lt;sup&gt;1&lt;/sup&gt;, Kesara Na-Bangchang&lt;sup&gt;2,3&lt;/sup&gt;, Kusuma Sriyakul&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathumthani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat. University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathumthani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Intanri Kurniati</style></author><author><style face="normal" font="default" size="100%">Agustyas Tjiptaningrum</style></author><author><style face="normal" font="default" size="100%">Raja Iqbal Mulya Harahap</style></author><author><style face="normal" font="default" size="100%">Bayu Putra Danan Jaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Serum Trace Element Levels in Type 2 DM Patients and its Correlation with Glycemic Control</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">glycemic control</style></keyword><keyword><style  face="normal" font="default" size="100%">HbA1c</style></keyword><keyword><style  face="normal" font="default" size="100%">trace element serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">660-663</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Type 2 diabetes mellitus, a chronic metabolic disorder, is known to impact serum trace element levels. Objectives: to investigates the association between serum trace elements (Co, Cr, and Cu) and glycemic control in individuals with type 2 diabetes. &lt;strong&gt;Material and Methods:&lt;/strong&gt; A 209 type 2 diabetes patients from Dr. H. Abdul Moeloek Hospital in Bandar Lampung and Hasan Sadikin Hospital in Bandung participated in the study. Patients underwent assessments for serum trace element levels (Co, Cr, and Cu) and glycemic control indicators (FBG and HbA1c). &lt;strong&gt;Results:&lt;/strong&gt; Results indicated significantly lower Co levels in uncontrolled diabetes versus controlled cases (P&amp;lt;0.05). Co, Cr, and Cu levels displayed a significant negative correlation with HbA1c (P&amp;lt;0.05), while Cr and Cu showed a significant negative correlation with FBG (P&amp;lt;0.05). Age did not show significant correlations with serum trace element levels. &lt;strong&gt;Conclusion:&lt;/strong&gt; serum trace element levels (Co, Cr, Cu) are inversely linked to glycemic control in type 2 diabetes individuals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">660</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Intanri Kurniati&lt;sup&gt;1&lt;/sup&gt;*, Agustyas Tjiptaningrum&lt;sup&gt;1&lt;/sup&gt;, Raja Iqbal Mulya Harahap&lt;sup&gt;2&lt;/sup&gt;, Bayu Putra Danan Jaya&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Lampung, Bandar Lampung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Padjajaran – Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Histology and Pathology Laboratory, Faculty of Medicine, Universitas Lampung, Bandar Lampung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Yuyun Afrianti</style></author><author><style face="normal" font="default" size="100%">Andi Indahwaty Sidin</style></author><author><style face="normal" font="default" size="100%">Noer Bahry Noor</style></author><author><style face="normal" font="default" size="100%">Syahrir A. Pasinringi</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Ridwan M. Thaha</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study on Factors that Influence the High Organizational Citizenship Behavior (OCB) of Makassar Ethnic Nurses in LANTO Hospital DG Pasewang Jeneponto in 2024.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hospitals</style></keyword><keyword><style  face="normal" font="default" size="100%">Makassar Ethnicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nurses</style></keyword><keyword><style  face="normal" font="default" size="100%">Organizational Citizenship Behavior</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">312-318</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Organizational Citizenship Behavior (OCB) is behavior carried out by an employee that exceeds formal work obligations, but has a good impact because it supports organizational effectiveness. Culture value is one of the factors for the high level of organizational citizenship behavior in Makassar ethnic nurses. According to the theory that researchers read, it is not only culture values that are a factor in high OCB. There are several factors that influence OCB, including Workplace Variables, HRM Policies &amp;amp; Practices, Culture, Contextual Factors, Work Centrality, Org Service Orientation, Org Reputation Threat, Dispositional Variables, Org Commitment, Demographic Variables, Personality Variables, Leader Supportive. Researchers became interested because this research only explored cultural values. Researchers want to look for other factors that influence the high OCB of the Makassar tribe at Lanto Dg Pasewang Jeneponto Regional Hospital so that they can be explored in more depth and become input for hospitals and other organizations. &lt;strong&gt;Methods: &lt;/strong&gt;The type of research carried out is qualitative research with a phenomenological approach. The informants in the research were 3 key informants consisting of the hospital director, head of nursing and head of the inpatient room and 7 regular informants consisting of several nurses at Lanto Dg Pasewang Jeneponto Regional Hospital. &lt;strong&gt;Results:&lt;/strong&gt; Based on the results of interviews conducted by writers and ethnic Makassar nurses at Lanto Dg Pasewang Jeneponto Regional Hospital, there are several factors that influence the high level of OCB attitudes. Divided into 2 factors, namely internal and external. Internal factors include aspects originating from individual members of the organization, while external factors relate to the organizational environment and culture within it. Internal and external factors are interrelated in increasing OCB. Internal factors include aspects originating from individual members of the organization which include Dispositional Variables, Organizational Service, Organizational Commitment, Personality Variables, and Work Centrality. External factors relate to the organizational environment and culture within it, which include Workplace Variables, HRM Policies &amp;amp; Practices, Culture Values, Contextual Factors, Organizational Reputation Treats, Demographic Variables, and Leader Supportiveness. &lt;strong&gt;Conclusion:&lt;/strong&gt; These twelve factors influence the high level of Organizational Citizenship Behavior (OCB) in Makassar ethnic nurses at Lanto Dg Pasewang Jeneponto Regional Hospital.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">312</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Yuyun Afrianti&lt;sup&gt;1,*&lt;/sup&gt;, Andi Indahwaty Sidin&lt;sup&gt;1,2,*&lt;/sup&gt;, Noer Bahry Noor&lt;sup&gt;1,2&lt;/sup&gt;, Syahrir A. Pasinringi&lt;sup&gt;1&lt;/sup&gt;, Stang&lt;sup&gt;2&lt;/sup&gt;, Ridwan M. Thaha&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hospital Administration Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Management Study Program, Faculty of Economics and Business, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susana Rubio-Guevara</style></author><author><style face="normal" font="default" size="100%">Olga Castillo-Medina</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Dan Altamirano-Sarmiento</style></author><author><style face="normal" font="default" size="100%">Elena Caceres-Andonaire</style></author><author><style face="normal" font="default" size="100%">Matilde Farias</style></author><author><style face="normal" font="default" size="100%">Nayly Chinchay</style></author><author><style face="normal" font="default" size="100%">Claudia Guerrero</style></author><author><style face="normal" font="default" size="100%">Josue Flores</style></author><author><style face="normal" font="default" size="100%">Edgar Vilela</style></author><author><style face="normal" font="default" size="100%">Sidny Nunez</style></author><author><style face="normal" font="default" size="100%">Janina Sernaque</style></author><author><style face="normal" font="default" size="100%">Felipe Pacherres</style></author><author><style face="normal" font="default" size="100%">Gabriela Mena</style></author><author><style face="normal" font="default" size="100%">Maria Trillo</style></author><author><style face="normal" font="default" size="100%">Julio Amayo</style></author><author><style face="normal" font="default" size="100%">Karyn Olascuaga-Castillo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vaccinium corymbosum: Phenolic Compound Content and Effect of Fruit Extract on Blood Glucose in Healthy Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Blueberry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 Diabetes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">716-725</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In the context of the increasing prevalence of metabolic diseases such as diabetes, the search for natural compounds with potential impact on glycemic regulation has become a crucial area of research. Among the numerous options available, &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; extract, commonly known as &quot;blueberry&quot;, has emerged as a promising candidate due to its rich composition of phytochemicals with antioxidant, anti-inflammatory and hypoglycemic properties. The aim of this study was to determine the total phenolic content (TPC) and the activity of &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; (&quot;blueberry&quot;) fruit extract on glycemia in healthy mice. &lt;strong&gt;Methods: &lt;/strong&gt;The Folin-Ciocalteau method was applied in order to quantify the phenolic compounds and the BE was administered to 25 mice distributed in six groups: control, negative control, experimental-D1- D2-D3, which were administered the BE in doses of 40, 80 and 120 mg/kg b.w. respectively; and insulin group; which were subjected to the glucose tolerance test (GTT) taking blood samples after 30, 60, 120 and 180 minutes. &lt;strong&gt;Results:&lt;/strong&gt; The total phenolic content (TPC) amount found in the berries was 3.79±0.06 GAE/dry weight (mg/g) and 18.96±0.28 GAE/solution (mg/L). Statistically significant differences were observed between the three doses of BE and the negative control during GTT as well as induced a significant reduction in area under the curve (AUC) compared to the negative control. &lt;strong&gt;Conclusions:&lt;/strong&gt; the three doses of the BE decreased glucose levels being the dose of 40 mg/kg b.w. the one that produced a statistically significant decrease with respect to the doses of 80 and 120 mg/kg b.w. during GTT.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">716</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Susana Rubio-Guevara&lt;sup&gt;1,2&lt;/sup&gt;, Olga Castillo-Medina&lt;sup&gt;1&lt;/sup&gt;, Marleni Villacorta- Zavaleta&lt;sup&gt;1&lt;/sup&gt;, Cyntia Blanco-Olano&lt;sup&gt;1&lt;/sup&gt;, Dan Altamirano-Sarmiento&lt;sup&gt;1&lt;/sup&gt;, Elena Cáceres-Andonaire&lt;sup&gt;1&lt;/sup&gt;, Matilde Farias&lt;sup&gt;2&lt;/sup&gt;, Nayly Chinchay&lt;sup&gt;2&lt;/sup&gt;, Claudia Guerrero&lt;sup&gt;2&lt;/sup&gt;, Josue Flores&lt;sup&gt;2&lt;/sup&gt;, Edgar Vilela&lt;sup&gt;2&lt;/sup&gt;, Sidny Nunez&lt;sup&gt;2&lt;/sup&gt;, Janina Sernaque&lt;sup&gt;2&lt;/sup&gt;, Felipe Pacherres&lt;sup&gt;2&lt;/sup&gt;, Gabriela Mena&lt;sup&gt;2&lt;/sup&gt;, Maria Trillo&lt;sup&gt;2&lt;/sup&gt;, Julio Amayo&lt;sup&gt;2&lt;/sup&gt;, Karyn Olascuaga-Castillo&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PharmaScience Research Group. Pharmacology Laboratory. School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Trujillo. PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Piura. PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herin Setianingsih</style></author><author><style face="normal" font="default" size="100%">Nasywa Zahra Sajida Tsuroyya</style></author><author><style face="normal" font="default" size="100%">Prawesty Diah Utami</style></author><author><style face="normal" font="default" size="100%">Riami</style></author><author><style face="normal" font="default" size="100%">Nanang Wiyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Visual Mapping and Future Direction of Marine Products Supplementary and Chemotherapy in The Treatment of Breast Cancer. A Bibliometric</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Bibliometric</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine products</style></keyword><keyword><style  face="normal" font="default" size="100%">Visual mapping</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1379-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Marine products have gained attention for their potential benefits in the treatment of breast cancer, offering an alternative or supplementary approach to traditional therapies. While they are not intended to replace established medical treatments like chemotherapy or surgery, marine natural products have shown promise in providing symptom relief, enhancing the quality of life, and potentially improving treatment success for breast cancer patients. Studies have explored the use of marine products in conjunction with chemotherapy for their palliative care benefits and as adjuvants to conventional therapies. Marinederived compounds have been investigated for their anticancer properties, including apoptosis induction, anti-proliferative effects, and modulation of signaling pathways involved in breast cancer progression. These natural products offer a complementary avenue for managing breast cancer, potentially enhancing treatment outcomes, and addressing therapeutic challenges. The utilization of marine products in breast cancer therapy dates back to ancient times when various cultures recognized the therapeutic benefits of plants, herbs, and marine resources. The purpose of this study is to visually map and guide future research on supplementary marine products and chemotherapy in breast cancer based on bibliometric analysis&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1379</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herin Setianingsih&lt;sup&gt;1*&lt;/sup&gt;, Nasywa Zahra Sajida Tsuroyya&lt;sup&gt;1&lt;/sup&gt;, Prawesty Diah Utami&lt;sup&gt;1&lt;/sup&gt;, Riami&lt;sup&gt;1&lt;/sup&gt;, Nanang Wiyono&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Apia Unmehopa</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Muhammad Alwy Arifin</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Accessibility of Mother and Child Health Services to Stunting Incidence in Leti Island, Southwest Maluku District</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Growth.</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Services</style></keyword><keyword><style  face="normal" font="default" size="100%">Mother</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword><keyword><style  face="normal" font="default" size="100%">Toddlers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">856-860</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the nutritional problems that can worsen the quality of life of children in achieving growth and development is stunting. Stunting receives greater attention than other nutritional statuses because in addition to a higher prevalence it can also indicate something more serious than just short body size. This type of research is a quantitative study that uses analytic observational with a case control study design to see the effect of the independent variables on the dependent variable. The sampling technique in this study was simple random sampling with a total sample of 164 people, 82 people in the case group and 82 people in the control group. The results of this study indicate that there is an effect between exclusive breastfeeding and health services on the incidence of stunting, while for the basic immunization variable there is no effect on the incidence of stunting. Meanwhile, based on the multivariate test, it was found that the variable that had the most influence on the incidence of stunting was health services. As for suggestions for this research, it is hoped that the Health Service will further improve health services to monitor the growth of toddlers and for mothers of toddlers to visit health services regularly.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">856</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Apia Unmehopa&lt;sup&gt;1,*&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Indar&lt;sup&gt;2&lt;/sup&gt;, Muhammad Alwy Arifin&lt;sup&gt;2&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;3&lt;/sup&gt;, Stang&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Health Administration and Policy Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Population Biostatistics and Family Planning, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teguh Triyono</style></author><author><style face="normal" font="default" size="100%">Tsaniatul Afifah</style></author><author><style face="normal" font="default" size="100%">Usi Sukorini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Deferred Blood Donor Candidates at Dr. Sardjito Hospital, Yogyakarta, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Donors rejected</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Transfusion</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">333-337</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The selection of blood donor candidates contributes to the safety of donors and donor recipients. An understanding of the characteristics, demographic characteristics, and types of potential blood donors are essential to obtain an accurate picture of the donor donors, thereby guiding recruitment strategies and providing benchmarks to assess the success of blood donation. &lt;strong&gt;Objective:&lt;/strong&gt; This scientific work aims to analyze the deferred blood donor candidates annually based on the required blood donor characteristics at the Blood Transfusion Unit (BTU) of Dr. Sardjito Hospital, Yogyakarta, Indonesia, from 2017 to 2019.&lt;strong&gt; Method:&lt;/strong&gt; This observational analytic study applied a retrospective design and was conducted at Dr. Sardjito Hospital, Yogyakarta. The data were collected from the donor registration information system and database in the blood request system for the 2017-2019 period. The statistical analysis was conducted using the Chi-Square test in the SPSS version 22. &lt;strong&gt;Results: &lt;/strong&gt;The deferred blood donor candidates in 2017-2019 amounted to 618 (0.82%) out of 75,067 total blood donors, most of whom were female, reaching an annual percentage of 50.7% in 2017, 50.9% in 2018, and 59.1% in 2019. The age range of both male and female deferred blood donor candidates was 17-30 years. The Hb levels of &amp;lt; 12.5 g/dL were mostly found in female blood donors, reaching a peak of 82.4% in 2017, 83.9% in 2018, and 85.4.6% in 2019. Voluntary blood donors accounted for 94.7% (in 2017), 98.6% (in 2018), and 100% (in 2019) of the female deferred blood donor candidates. All analytical tests resulted in a p-value of &amp;lt; 0.0001. Most of the deferred blood donor candidates had blood type O with a p = 0.026. The most common cause of deferral was high or low Hb levels in female blood donors with an age range of 17-30 years. &lt;strong&gt;Conclusions:&lt;/strong&gt; The deferred blood donor candidates in 2017-2019 amounted to 618 (0.82%) out of 75,067 total blood donors, most of whom were female with the most common deferral reason of Hb levels &amp;lt; 12.5 g/dL in the age range of 17-30 years.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">333</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Teguh Triyono&lt;sup&gt;1,*&lt;/sup&gt;, Tsaniatul Afifah&lt;sup&gt;2&lt;/sup&gt;, Usi Sukorini&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Specialist Education Program (PPDS) of Clinical Pathology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hatthapan Wipanso</style></author><author><style face="normal" font="default" size="100%">Bhanubong Bongcheewin</style></author><author><style face="normal" font="default" size="100%">Suppachai Tiyaworanant</style></author><author><style face="normal" font="default" size="100%">Suksalin Booranasubkajorn</style></author><author><style face="normal" font="default" size="100%">Natchagorn Lumlerdkij</style></author><author><style face="normal" font="default" size="100%">Pravit Akarasereenont</style></author></authors><tertiary-authors><author><style face="normal" font="default" size="100%">Pemika Siriboonsong</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">An Analysis of Local Knowledge of Phit-Samdaeng in Yang Sisurat District, Maha Sarakham Province and The Medicinal Plants Used to Relieve Its Symptoms</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alternative medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Folk knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Phit-Samdaeng.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">259-265</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; “&lt;em&gt;Phit-Samdaeng&lt;/em&gt;” is a Thai term often used to refer to an illness of eating unsuitable foods. However, its use in a diagnosis is limited due to the unclear definition and description. This study aimed to compare knowledge of &lt;em&gt;Phit-Samdaeng&lt;/em&gt; symptoms and treatments in Northeastern folk medicine, Thai Traditional Medicine, and medicinal plants in the Yang Sisurat District of Thailand. &lt;strong&gt;Methods: &lt;/strong&gt;Semistructured interviews and participatory observations were used to collect data from 12 folk healers. Questions were designed to obtain local knowledge of &lt;em&gt;Phit-Samdaeng&lt;/em&gt; and medicinal plants. The data was analyzed using descriptive statistics, comparison and interpretation. &lt;strong&gt;Results:&lt;/strong&gt; Some symptoms of &lt;em&gt;Phit-Samdaeng&lt;/em&gt; in the nine scriptures of Thai Traditional Medicine, &lt;em&gt;Tumraya Silajaruek Watprachethupon&lt;/em&gt;, and of &lt;em&gt;Kin-Phit&lt;/em&gt; and&lt;em&gt; Phit-Kaboon&lt;/em&gt;, in &lt;em&gt;Tamraya Boran Isan&lt;/em&gt;, were similar in &lt;em&gt;Yang Sisurat.&lt;/em&gt; However, the names were different. There were also differences in species and the recipes of herbal remedies among folk healers and in the textbooks. The most used plants to treat &lt;em&gt;Phit-Samdaeng &lt;/em&gt;by folk healers were&lt;em&gt; Clerodendrum paniculatum &lt;/em&gt;L. and C&lt;em&gt;lausena wallichii Oliv.&lt;/em&gt; var. &lt;em&gt;guillauminii &lt;/em&gt;(Tanaka) Molino. Only nine species had pharmacological effects relating to &lt;em&gt;Phit-Samdaeng&lt;/em&gt; treatment. &lt;strong&gt;Conclusions: &lt;/strong&gt;The knowledge of &lt;em&gt;Phit-Samdaeng &lt;/em&gt;symptoms in &lt;em&gt;Yang Sisurat&lt;/em&gt; District were consistent with the Northeast folk medicine and Thai Traditional Medicine. The most commonly used species were native plants of Thailand. However, information on the medicinal taste and property from scriptures and pharmacological evidence is lacking. Therefore, the pharmacological activity and toxicity of herbal remedies should be further investigated for efficacy and safety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hatthapan Wipanso&lt;sup&gt;1&lt;/sup&gt;, Bhanubong Bongcheewin&lt;sup&gt;2&lt;/sup&gt;, Suppachai Tiyaworanant&lt;sup&gt;3&lt;/sup&gt;, Suksalin Booranasubkajorn&lt;sup&gt;1&lt;/sup&gt;, Natchagorn Lumlerdkij&lt;sup&gt;1&lt;/sup&gt;, Pemika Siriboonsong&lt;sup&gt;1&lt;/sup&gt;, Pravit Akarasereenont&lt;sup&gt;1,4,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center of Applied Thai Traditional Medicine, Faculty of Medicine Siriraj Medicine, Mahidol University, Bangkok, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Botany, Faculty of Pharmacy, Mahidol University, Bangkok, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine Siriraj Medicine, Mahidol University, Bangkok, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Ridwan Mochtar Thaha</style></author><author><style face="normal" font="default" size="100%">St. Rosmanely</style></author><author><style face="normal" font="default" size="100%">Rizky Chaeraty Syam</style></author><author><style face="normal" font="default" size="100%">A. Tenri Nurafni Aprilyani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Lung TB Treatment Strategy in Pangkep District Year 2022</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Policy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary Tuberculosis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment strategy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">524-527</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Tuberculosis (TB) is still a world concern with morbidity rates that have not been fully recorded but mortality data continues to increase, so strengthening coordination strategies with various related networks is very important in the target of achieving TB eradication nationally and globally in 2035. This research is a qualitative research carried out to identify phenomena and problems related to pulmonary TB management strategies in Pangkep Regency in October 2022. Data were collected through Focus Group Discussions (FGD), which were then analyzed qualitatively through 3 stages, namely data reduction, data presentation, and data verification as well as drawing conclusions. The results of the study show several important points in the strategy for handling pulmonary TB in Pangkep Regency, namely the applicable policies still follow the policies from the center, access for island areas must have a special strategy, the TB control strategy used is TOSS and there is collaboration between cross-sectors, electronic recording is carried out through SITB and manuals, as well as monitoring and evaluation activities carried out by looking through the system, conducting routine monitoring and evaluation, as well as field visits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">524</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muhammad Syafar&lt;sup&gt;1,*&lt;/sup&gt;, Ridwan Mochtar Thaha&lt;sup&gt;2&lt;/sup&gt;, St. Rosmanely&lt;sup&gt;3&lt;/sup&gt;, Rizky Chaeraty Syam&lt;sup&gt;4&lt;/sup&gt;, A. Tenri Nurafni Aprilyani&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Health Policy and Administration, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Nuriana</style></author><author><style face="normal" font="default" size="100%">Balqis</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Policy Recommendations in Efforts to Control Positive  COVID-19 Cases in South Sulawesi Province, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Policy</style></keyword><keyword><style  face="normal" font="default" size="100%">Policy Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Surveillance</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaccination</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1230-1235</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Inconsistent COVID-19 policies have caused the government to experience a degradation in public trust. So, it is necessary to propose policy recommendations for controlling positive COVID-19 cases that receive support from various multi-sectoral areas. &lt;strong&gt;Method: &lt;/strong&gt;This research was conducted in January–May 2023. This type of research is qualitative-exploratory, using case study methods through indepth interviews and literature studies of all informants. Sampling was purposive sampling. This research variable uses Patton and Sawicki's alternative policy criteria theory (1986). &lt;strong&gt;Results:&lt;/strong&gt; The proposed policy recommendations are increasing COVID-19 vaccine coverage and surveillance for monitoring coronavirus mutations. The two policy recommendations have met technical feasibility because they have clear outcomes, where the outcome of vaccination is to establish herd immunity. In contrast, surveillance of coronavirus mutations has the outcome of analyzing the efficacy of the COVID-19 vaccine. From the economic and financial possibility side, a budget is available with the advantage of carrying out normal activities without any restrictions and efficiency in the health budget. Regarding political viability, the government supports the policy, does not violate the rules, and serves the community's needs. Regarding administrative operability, the government as the authorized party is considered to have adequate capability, organizational support, and institutional commitment. &lt;strong&gt;Conclusion:&lt;/strong&gt; The policy recommendations proposed by policymakers and epidemiology experts are increasing COVID-19 vaccination coverage and monitoring surveillance of coronavirus mutations, and it is hoped that the South Sulawesi Provincial Government can consider the proposed policy recommendations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1230</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sri Nuriana&lt;sup&gt;1,*&lt;/sup&gt;, Balqis&lt;sup&gt;2&lt;/sup&gt; , Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt; , Indar&lt;sup&gt;2&lt;/sup&gt; , Yahya Thamrin&lt;sup&gt;3&lt;/sup&gt; , Stang&lt;sup&gt;4&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of the Master's Program in Health Administration and Policy, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Population Biostatistics / Family Planning, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wardah Rahmatul Islamiyah</style></author><author><style face="normal" font="default" size="100%">Nasronudin</style></author><author><style face="normal" font="default" size="100%">Abdulloh Machin</style></author><author><style face="normal" font="default" size="100%">Iin Ernawati</style></author><author><style face="normal" font="default" size="100%">Yunita Dwi Tanti</style></author><author><style face="normal" font="default" size="100%">Nur Jaya</style></author><author><style face="normal" font="default" size="100%">Farah Medina</style></author><author><style face="normal" font="default" size="100%">Fathia Faza Rahmadanita</style></author><author><style face="normal" font="default" size="100%">Paulus Sugianto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of The Effect of Leptin, AMPK, Adiponectin, and NPY Markers on Changes in Body Weight of Childhood Epileptic Using Valproic Acid Monotherapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adiponectin</style></keyword><keyword><style  face="normal" font="default" size="100%">AMPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Childhood.</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">NPY</style></keyword><keyword><style  face="normal" font="default" size="100%">Valproic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight gain</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">150-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Epilepsy is a neurological disorder that occurs due to abnormal neurons in the brain and an imbalance between excitation and inhibition in the central nervous system. The first line of OAE in children is VPA (Valproate Acid). However, long-term use can cause weight gain with a frequency of 10-70%. The underlying mechanism of weight gain in patients remains unclear. &lt;strong&gt;Purpose: &lt;/strong&gt;This study aimed to analyze the relationship between levels of biomarkers AMPK, NPY, Leptin, and Adiponectin on changes in body weight in patients with epileptic seizures using VPA monotherapy. Method: This study is an observational cohort design. Data collection in April-June 2019. Inclusion criteria were children aged 2-10 years who used VPA requirement less than two years, not taking any drugs that affect body weight, not diagnose systemic lupus, nephrotic syndrome, and diabetes mellitus. Bodyweight and all biomarkers measurement on subjects who came to the clinic at the time of study and at least after one month of taking VPA. A total of 17 subjects participated in this study.&lt;strong&gt; Result: &lt;/strong&gt;The results of the statistical multivariate analysis test of VPA dosage on changes in body weight and biomarker levels found that Leptin, AMPK, Adiponectin did not significantly increase in body weight (p&amp;gt;0.05), but NPY significant increase in body weight (p&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; NPY is the most potent for appetite enhancing, preferential effect on carbohydrate intake, weight regulation, energy storage, and expenditure. Increase production of NPY, there is an increase in energy intake and then increases fat storage and body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wardah Rahmatul Islamiyah1&lt;sup&gt;,2&lt;/sup&gt;, Nasronudin&lt;sup&gt;3,4,*&lt;/sup&gt;, Abdulloh Machin&lt;sup&gt;2&lt;/sup&gt;, Iin Ernawati&lt;sup&gt;5&lt;/sup&gt;, Yunita Dwi Tanti&lt;sup&gt;6&lt;/sup&gt;, Nur Jaya&lt;sup&gt;7&lt;/sup&gt;, Farah Medina&lt;sup&gt;8&lt;/sup&gt;, Fathia Faza Rahmadanita&lt;sup&gt;9&lt;/sup&gt;, Paulus Sugianto&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universitas Airlangga Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Akademi Farmasi Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Ngudi Waluyo Hospital Wlingi Blitar, INDONESIA. 7Budi Agung Hospital, Palu, INDONESIA. 8Oncology Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Faculty of Medicine and Health Science Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lalbiakngheti Tlau</style></author><author><style face="normal" font="default" size="100%">Lucy Lalawmpuii</style></author><author><style face="normal" font="default" size="100%">P.B. Lalthanpuii</style></author><author><style face="normal" font="default" size="100%">K. Lalchhandama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Phytochemical and Antibacterial Properties of the Indigenous Mizo Medicinal Plant, Helicia Excelsa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Helicia excelsa</style></keyword><keyword><style  face="normal" font="default" size="100%">Mizo traditional medicine.</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">823-828</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Helicia excelsa &lt;/em&gt;(Roxb.) Bl. is a scarcely known medicinal plant and is native to Southeast Asia. It is most notably used for the treatment of gastric problems in the Mizo traditional medicine in India.&lt;strong&gt; Method: &lt;/strong&gt;The leaves of &lt;em&gt;H. excelsa&lt;/em&gt; were collected from Aizawl, Mizoram, India. An extract was prepared using chloroform. Qualitative phytochemical tests were performed to detect the important phytocompounds. The antioxidant activity was determined by total phenolic content, total flavonoid content, total antioxidant content, DPPH- and ferric-reducing antioxidant power. Antibacterial activity was evaluated by agar well-diffusion method. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;H. excelsa&lt;/em&gt; leaf contains amino acids, alkaloids, carbohydrates, glycosides, phenols, phytosterols, proteins, and tannins. It showed inhibition in selected Gram-negative and Gram-positive bacteria. The phenol, flavonoid and total antioxidant contents were 4.52±0.09 gallic acid equivalent (GAE mg/g), 64.27±1.04 quercetin equivalent (QE mg/g), 11.39±0.45 ascorbic acid equivalent (AAE mg/g) respectively. IC50 value of DPPH-scavenging activity was 5.67±0.36. The ferric ion-reducing power showed concentration-dependent activity. The plant extract showed growth-inhibitory actions against Gram-negative bacterium, Escherichia coli, and Gram-positive species, Bacillus cereus and Staphylococcus aureus. :&lt;strong&gt;Conclusion &lt;/strong&gt;&lt;em&gt;H. excelsa &lt;/em&gt;leaf contains important bioactive compounds that need to be identified. The antioxidant and antibacterial activities support the basis of its medicinal application.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">823</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lalbiakngheti Tlau, Lucy Lalawmpuii, P.B. Lalthanpuii, K. Lalchhandama*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Life Sciences, Pachhunga University College, Aizawl 796 001, Mizoram, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noufou Ouédraogo</style></author><author><style face="normal" font="default" size="100%">W. Leila Marie Esther Belem-Kabré</style></author><author><style face="normal" font="default" size="100%">A.M. Emmanuel Thiombiano</style></author><author><style face="normal" font="default" size="100%">Tata Kadiatou Traoré</style></author><author><style face="normal" font="default" size="100%">Lazare Belemnaba</style></author><author><style face="normal" font="default" size="100%">Moussa Ouédraogo</style></author><author><style face="normal" font="default" size="100%">Innocent Pierre Guissou</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Potential of Glycoside Flavonoids from Pterocarpus erinaceus Poir. (Fabaceae) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">593-598</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Chronic diseases have become one of the leading causes of death worldwide in recent years. Despite tremendous advances in the treatments of diseases, several concerns remain. Those with inflammatory components are alternatively treated or completed in Burkina Faso with medicinal plants. The present study was designed to identify and evaluate the anti-inflammatory potential of glycoside flavonoids from &lt;em&gt;Pterocarpus Erinaceus &lt;/em&gt;leaves. &lt;strong&gt;Methods: &lt;/strong&gt;The ﬂavonoids contained in &lt;em&gt;Pterocarpus Erinaceus&lt;/em&gt; aerial parts were extracted, identified, and characterized. Sequential soxhlet extraction was subjected to preliminary phytochemical screening, and characterization of isolated ﬂavonoid was done by U.V., I.R., 1H &amp;amp; 13C N.M.R. and MS. Subsequently, isolates were tested&lt;em&gt; in vitro&lt;/em&gt; for their antiinflammatory potential as well as their antioxidant capacities. &lt;strong&gt;Results: &lt;/strong&gt;Five compounds were determined as corresponding to 3’,4’,5,7-tetrahydroxy flavone (luteolin); quercetin-3-O- sophoroside; quercetin- 3-0-β-glucose (isoquercitrin); Kaempferol-3-O-sophoroside and 3,3’,4’,5,7-pentahydroxyflavone-3- rhamnoglucoside (rutin). Concentrations of quercetin-3-O- sophoroside and quercetin-3-0-β-glucose that inhibit 50% of pro-inflammatory enzymes’ activities were expressed in μg/mL. They were respectively 18.07 ± 0.78 and 32.27 ± 2.02 for xanthine oxidase, 1.12 ± 0.018 and 11.53 ± 0.52 for lipoxygenase, 26.91 ± 0.34 and 19.54 ± 0.25 for acetylcholinesterase. Prevention of the degradation of deoxyribose test gave respectively 19.32 ± 1.08 μg/mL and 26.21 ± 2.25 μg/mL for quercetin-3-O- sophoroside and quercetin-3-O- β-glucose while the anti-DPPH free radical potential was 3.41 ± 0.82 and 2.90 ± 0.18 μg/ mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results may justify the traditional uses of P. erinaceus in treating diseases with an inflammatory component.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">593</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Noufou Ouédraogo&lt;sup&gt;1,3&lt;/sup&gt;, W. Leila Marie Esther Belem-Kabré&lt;sup&gt;1,2,&lt;/sup&gt;*, A.M. Emmanuel Thiombiano&lt;sup&gt;2&lt;/sup&gt;, Tata Kadiatou Traoré&lt;sup&gt;1,3&lt;/sup&gt;, Lazare Belemnaba&lt;sup&gt;1&lt;/sup&gt;, Moussa Ouédraogo&lt;sup&gt;3&lt;/sup&gt;, Innocent Pierre Guissou&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7047 Ouagadougou 03, BURKINA FASO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, BURKINA FASO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratoire de développement du médicament (LADME) / CEA-CFOREM, Ecole Doctorale Sciences de la Santé, Université Joseph KI-ZERBO 03 BP 7021 Ouagadougou 03, BURKINA FASO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasad A. Thakurdesai</style></author><author><style face="normal" font="default" size="100%">Pallavi O. Deshpande</style></author><author><style face="normal" font="default" size="100%">Mukul P. Pore</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization, Preclinical Efficacy and Toxicity Evaluations of Flavonoids Glycosides based Standardized Fenugreek Seed Extract (FEFLG)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">CD38+ enzyme inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomal aberration.</style></keyword><keyword><style  face="normal" font="default" size="100%">Fenugreek seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">Mutagenicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">90-105</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Fenugreek seeds, a natural food chain raw material, is known to have many flavonoid glycosides. &lt;strong&gt;Objective:&lt;/strong&gt; Characterization, preclinical efficacy, and safety evaluation of flavonoid glycosidebased standardized fenugreek seed extract (FEFLG). &lt;strong&gt;Methods:&lt;/strong&gt; FEFLG was characterized for a group of flavonoid glycoside marker compounds by HPLC. The CD38+ enzyme inhibition efficacy was assessed &lt;em&gt;in vitro.&lt;/em&gt; In addition, acute oral toxicity (AOT) and subchronic, 90-day repeated-dose oral toxicity (&lt;em&gt;in vivo&lt;/em&gt;), mutagenicity (AMES test, &lt;em&gt;in vitro&lt;/em&gt;) and chromosome aberration test (&lt;em&gt;in vitro&lt;/em&gt;) of FEFLG were evaluated. &lt;strong&gt;Results&lt;/strong&gt;: The FEFLG was found to have 49.85% of total flavonoid glycosides content in FEFLG (25.15% of Group 1: vitexin, isovitexin and vitexin 2-o- rhamnoside and 24.70% of Group 2 (vicenin derivatives, schaftoside, iso-schaftoside, orientin and iso-orientin). FEFLG showed CD38+ enzyme inhibition&lt;em&gt; in vitro&lt;/em&gt; (IC50= 0.96 μg/ml) equivalent to the positive control, apigenin. FEFLG did not show any toxicity at an acute oral dose of more than 2000 mg/kg (median lethal dose, LD50) with a limit dose of 5000 mg/kg. The 90-day repeated-dose oral administration of FEFLG did not induce significant toxicological changes till the maximum dose of 1000 mg/kg in male and female rats, indicating no observed adverse effect level, NOAEL ≥ 1000 mg/kg. FEFLG did not show mutagenicity (up to a concentration of 5000 μg/plate) or structural chromosomal aberrations (up to 5000 μg /ml). &lt;strong&gt;Conclusion:&lt;/strong&gt; The CD38+ enzyme inhibitor efficacy&lt;em&gt; in vitro&lt;/em&gt;, oral safety &lt;em&gt;in vivo&lt;/em&gt; and absence of mutagenicity or genotoxicity of FEFLG indicated its potential for anti-aging applications.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">90</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Prasad A. Thakurdesai*, Pallavi O. Deshpande, Mukul P. Pore&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Indus Biotech Limited, Pune, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ankita singh</style></author><author><style face="normal" font="default" size="100%">Sunil Tejaswi</style></author><author><style face="normal" font="default" size="100%">Kenganora Mruthunjaya</style></author><author><style face="normal" font="default" size="100%">Suneeth Shetty</style></author><author><style face="normal" font="default" size="100%">Ambikathanaya U.K</style></author><author><style face="normal" font="default" size="100%">Sachin B. Manglekar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Evaluation of Microhardness and Color Change of Root dentin using Punica granatum (pomegranate extract), Sodium hypochlorite, Chlorhexidine and Normal saline as an Endodontic irrigant – An in vitro study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chlorhexidine.</style></keyword><keyword><style  face="normal" font="default" size="100%">Color change</style></keyword><keyword><style  face="normal" font="default" size="100%">Endodontic irrigant</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Microhardness</style></keyword><keyword><style  face="normal" font="default" size="100%">Punica granatum (pomegranate peel extract)</style></keyword><keyword><style  face="normal" font="default" size="100%">UVVIS spectrophotometer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">732-737</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;To evaluate the microhardness and change in color of root dentin using Punica granatum, sodium hypochlorite, chlorhexidine and normal saline as an endodontic irrigant and to implement their use in field of dentistry. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; 60 single rooted anterior teeth extracted due to periodontal and orthodontic reasons were collected. All the samples were decoronated to achieve constant length of 14mm. Patency of root canal was established using 10k file and working length was determined 1mm short of the file length. Each canal was prepared till F3 protaper. After preparation the samples were randomly divided into 4 groups: Group 1: Saline (Control); Group 2: 5% Sodium Hypochlorite; Group 3: 2% Chlorhexidine; Group 4: 5% Punica granatum (pomegranate peel extract). After grouping the samples were longitudinally sectioned. One half of the tooth sample was used for microhardness testing using Vickers microhardness indentor and the other half of sample was used for color change evaluation using spectrophotometer after irrigation with the test solutions on day 1 and day 7th post irrigation. &lt;strong&gt;Results:&lt;/strong&gt; The mean microhardness in all four groups decreased comparatively at post as compared to pre and the decrease was evident highest in sodium hypochlorite followed by chlorhexidine, pomegranate and saline the least. In regard to color change sodium hypochlorite, chlorhexidine and pomegranate all showed visible color changes after 7 day of irrigation with pomegranate showing the highest color change. Higher lightness was shown in Group 2 i.e., sodium hypochlorite whereas redness was seen more in Group 4 i.e., pomegranate and yellowish tint was more visible in Group 3. &lt;strong&gt;Conclusion&lt;/strong&gt;: 5% Punica granatum has showed negligible effect on microhardness of dentin but showed maximum color change when compared to chlorhexidine, sodium hypochlorite and saline.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">732</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ankita singh&lt;sup&gt;1&lt;/sup&gt;, Sunil Tejaswi&lt;sup&gt;2,*&lt;/sup&gt;, Kenganora Mruthunjaya&lt;sup&gt;3&lt;/sup&gt;, Suneeth Shetty&lt;sup&gt;4&lt;/sup&gt;, Ambikathanaya U.K&lt;sup&gt;4&lt;/sup&gt;, Sachin B. Manglekar&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post graduate student, JSS Dental College and Hospital, Mysore, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Reader, Department of Conservative dentistry and endodontics, JSS Dental College and Hospital, Mysore, Karanataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, JSS College of Pharmacy, Mysore, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Lecturer, JSS Dental College and Hospital, Mysore, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Bharathi Vidyapeeth Dental College and Hospital, Pune, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rena Normasari</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Damayanti Tinduh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Comparative Study of CFA and MIA Induction Models in Rat  Knee Arthritis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CFA</style></keyword><keyword><style  face="normal" font="default" size="100%">CTX-II</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-1β</style></keyword><keyword><style  face="normal" font="default" size="100%">MIA</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoarthritis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1197-1201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study presents another comparative review of knee joint arthritis induction in rats using two distinct methods: Complete Freund's Adjuvant (CFA) and monosodium iodoacetate (MIA). Different variables are assessed, including bodyweight changes, knee bend scores, and knee diameter measurements, as well as the quantification of interleukin-1β (IL-1β) and C-telopeptide of type II collagen (CTX-II) levels. CFA or MIA induction was used on rats, and 14 days were observed. Our data show that the impact of arthritis induction varies significantly across the two models. Both the CFA and MIA groups showed different changes in terms of bodyweight changes, knee bend scores, and knee diameter variations. Furthermore, the levels of IL-1β and CTX-II, both known indicators of inflammation and cartilage degeneration, were measured. Notably, IL-1β levels in the CFA group were considerably higher than in the MIA-induced rats, although CTX-II concentrations showed a contrary pattern. These findings highlight the need to carefully consider the induction approach when performing arthritis investigations in rats since the model used has a major impact on the reported physiological alterations. This study's comparative analysis provides useful information for researchers looking to use rat knee joint arthritis models, laying the groundwork for a better-informed selection of the best induction strategy depending on desired outcome metrics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1197</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rena Normasari&lt;sup&gt;1&lt;/sup&gt; , Bambang Purwanto&lt;sup&gt;2,&lt;/sup&gt;*, Damayanti Tinduh&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Physiology Department, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Physical Medicine and Rehabilitation Department, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Rahmani</style></author><author><style face="normal" font="default" size="100%">Arliangga Fahrezi</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of the Anti-Inflammatory Activity of Flavonoid  Bioactive Compounds Acetone Fraction and Steroid Fraction  Ethyl Acetate Sungkai Leaves In Vivo and In Silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflamatory; β-Sitesterol; Naringenin</style></keyword><keyword><style  face="normal" font="default" size="100%">P. canescens Jack</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1068-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the medicinal plants that is widely used by traditional communities is sungkai (&lt;em&gt;Peronema canescens &lt;/em&gt;Jack), which is known to contain secondary metabolite compounds of flavonoids, saponins, tannins, steroids, terpenoids, alkaloids, and phenols. This research aims to isolate secondary metabolite compounds from acetone and ethyl acetate fractions, which act as anti-inflammatory agents in vivo and in silico. Acetone and ethyl acetate fractions were isolated and characterized using UV-Vis and FT-IR. The In Vivo test was carried out on Mus musculus, while the In Silico test was carried out using the IL-10 and IFN-γ receptors, which play a role in inflammation and immunity. Our research results showed that the ethanolic (F1) and n-hexane (F2) fractions of &lt;em&gt;P. canescens &lt;/em&gt;extract had good anti-inflammatory activity with percent inhibition values of 58.12% and 56.59%, respectively. The characterization results showed that isolate F1 was a flavonoid group, Naringenin compound, while isolate F2 was a steroid group, &lt;em&gt;β&lt;/em&gt;-Sitosterol compound. Moreover, from the scoring docking results, &lt;em&gt;β-&lt;/em&gt;Sitesterol has tremendous potential as an anti-inflammatory than the compound naringenin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1068</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief&lt;sup&gt;1,2&lt;/sup&gt;, Rahmani1 , Arliangga Fahrezi&lt;sup&gt;1&lt;/sup&gt; , Sutrisno&lt;sup&gt;1 &lt;/sup&gt;, Indra Lasmana Tarigan&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product and Bioactive Compound Laboratory, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Muharam</style></author><author><style face="normal" font="default" size="100%">Nurhuda Sahar</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Luluk Yunaini</style></author><author><style face="normal" font="default" size="100%">Risqa Novita</style></author><author><style face="normal" font="default" size="100%">Rosalina Thuffi</style></author><author><style face="normal" font="default" size="100%">Conny Riana Tjampakasari</style></author><author><style face="normal" font="default" size="100%">Ponco Birowo</style></author><author><style face="normal" font="default" size="100%">Diyah Kristanty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Decreased Expression of Endocrine Glands Vascular Endothelial Growth Factor (EG-VEGF) in Rat Endometrial After Stimulation with Recombinants FSH Can be Reduce Implantation Rates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">EG-VEGF</style></keyword><keyword><style  face="normal" font="default" size="100%">Endometrial receptivity</style></keyword><keyword><style  face="normal" font="default" size="100%">rFSH</style></keyword><keyword><style  face="normal" font="default" size="100%">Secretory phase.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">707-713</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Decreased expression of EG-VEGF in human endometrium after administration of ovarian stimulators has been reported to adversely affect endometrial receptivity and low implantation rates. &lt;strong&gt;Objective:&lt;/strong&gt; To determine the effect of recombinant FSH administration on EG-VEGF protein in the endometrium of rats taken in the secretory phase and how it relates to endometrial receptivity. Design: A total of 36 female wistar rats with normal estrous cycles were randomly assigned to the natural cycle group (NC) and two stimulation groups (SC) which were injected with recombinant FSH at 12.5 IU and 25 IU intraperitoneally. Uterine necropsy and blood collection were performed on day 1, day 2, and day 3 after hCG administration. A total of 3 female rats from each group were mated with male rats (two males and three females in one cage). A successful marriage is indicated by the presence of a vaginal plug the next day. The level of EG-VEGF protein expression was assessed by immunohistochemical technique and steroid hormone levels were measured by the Elisa technique. &lt;strong&gt;Results&lt;/strong&gt;: ANOVA test, that the expression of EG-VEGF in the endometrial glands showed a significant decrease from the normal cycle group to the stimulated cycle group 1 (SC 1) and SC2 (P = 0.00), as well as the expression of EG-VEGF in the endometrial stroma. (P = 000). Steroid hormone levels did not show a significant decrease between the normal cycle group and the stimulated cycle group (P = 0.48 and P = 0.13). &lt;strong&gt;Conclusion:&lt;/strong&gt; Decreased EG-VEGF expression in rat endometrium after administration of recombinant FSH is associated with decreased endometrial receptivity which can reduce pregnancy rates.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">707</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raden Muharam&lt;sup&gt;1&lt;/sup&gt;, Nurhuda Sahar&lt;sup&gt;2&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;3,5,*&lt;/sup&gt;, Luluk Yunaini&lt;sup&gt;6&lt;/sup&gt;, Risqa Novita&lt;sup&gt;7&lt;/sup&gt;, Rosalina Thuffi&lt;sup&gt;8&lt;/sup&gt;, Conny Riana Tjampakasari&lt;sup&gt;9&lt;/sup&gt;, Ponco Birowo&lt;sup&gt;10&lt;/sup&gt;, Diyah Kristanty&lt;sup&gt;11&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Human Cancer Research Center, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Center of Biomedical and Basic Health Technology, Ministry of Health of the Republic of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Master Programe of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Urology Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumarawati T</style></author><author><style face="normal" font="default" size="100%">Chodidjah</style></author><author><style face="normal" font="default" size="100%">Dina Fatmawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Combination of Soybean and Phaleria macrocarpa Ethanol Extract on IL6, TNFα, VEGF and Fibroblasts in Mice Exposed to UVB</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin wound</style></keyword><keyword><style  face="normal" font="default" size="100%">UV B radiation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">6-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;UV exposure causes inflammation and the generation of reactive oxygen species, both of which contribute to skin aging. The purpose of this research was to determine how a combination of &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;extract and soybean extract affected the number of fibroblasts, VEGF, IL-6, and TNF alpha expression, and blood levels of IL-6 and TNF alpha in UV-B-exposed mice. In this study, mice were placed into four groups: one control group, three treatment groups, and a combination of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;:soybeans at a 1:1 ratio (com group). The mice were euthanized on days 5 and 21 for histological preparations and then examined under a light microscope. Using an Olympus C-21 microscope with an Optilab Advances camera at 1000x magnification, the fibroblast was studied by counting the number of fibroblast cells per field of view. The immunohistochemical approach was performed to analyze the expression of VEGF, IL-6, and TNF- in skin tissue. The ELISA technique was used to quantify the levels of IL-6 and TNF-alpha. SPSS ver 21 was used to analyze the data. On days 5 and 21, the number of fibroblasts and expression of VEGF, IL-6, and TNF alpha were significantly higher in the combination group than in the control, &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;, and soybean treatment groups. However, there was no significant change in IL-6 and TNF alpha levels across groups on days 5 and 21 (p &amp;gt; 0.05). Finally, a 1:1 mixture of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt; and soybeans reduced the number of fibroblasts and the production of VEGF, IL-6, and TNF alpha on days 5 and 21, but not in serum levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">6</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sumarawati T&lt;sup&gt;1,*&lt;/sup&gt;, Chodidjah&lt;sup&gt;2&lt;/sup&gt;, Dina Fatmawati&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomi, Faculty of Medicine, Universitas Islam Sultan Agung&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teguh Triyono</style></author><author><style face="normal" font="default" size="100%">Zelly Dia Rofinda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Platelet Concentrates (PCs) Leucodepletion on the Activation and Efficacy of Platelet Transfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CD62P</style></keyword><keyword><style  face="normal" font="default" size="100%">Corrected count increment</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet concentrates</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">223-227</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Platelet concentrates (PCs) are blood components transfused in thrombocytopenic patients, including patients with blood malignancies. PCs contain leukocytes, which can pose potential side effects and activate platelets, reducing the efficacy of platelet transfusion. The leucodepletion process can be carried out by filtration to reduce the leukocyte count. This study aims to determine the difference between the CD62P expression of nonleucodepleted and leucodepleted PCs and to determine the difference between the Corrected Count Increment (CCI) of patients transfused with nonleucodepleted and leucodepleted PCs. This analytic observational study with a cross-sectional design was carried out on PCs obtained from platelet-rich plasma (PRP-PC). PCs were transfused into 48 blood malignancy patients, Yogyakarta, consisting of two groups i.e the group transfused with nonleucodepleted PCs (24 patients) and the group transfused with leucodepleted PCs (24 patients). CD62P expression in PCs was measured by flow cytometry method, and the CCI of the patients was calculated based on the CCI formula. The difference between the median CD62P expression and CCI of the two groups was analyzed using the Mann- Whitney Test with a significance of p&amp;lt;0.05. The median CD62P expression of the nonleucodepleted and leucodepleted groups were 34.4% (16.8–94.4%) and 21.7% (6.2–34.0%), respectively. There was a statistically significant difference between the CD62P expression of the two groups (p = 0.00). The group transfused with nonleucodepleted, and leucodepleted PCs showed respective median CCI of 18.8 x 10&lt;sup&gt;9&lt;/sup&gt;/L (2.4–94.8 x 10&lt;sup&gt;9&lt;/sup&gt;/L) and 14.7 x 10&lt;sup&gt;9&lt;/sup&gt;/L (2.4–124.0 x 10&lt;sup&gt;9&lt;/sup&gt;/L). There was no statistically significant difference between the CCI of the two groups (p = 0.42). It can be concluded that the CD62P expression in the PCs of the leucodepleted group was significantly lower than those of the nonleucodepleted group and that there was no significant difference between the CCI of both groups.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Teguh Triyono&lt;sup&gt;1*&lt;/sup&gt;, Zelly Dia Rofinda&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Anwar Daud</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">M Sabir</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author><author><style face="normal" font="default" size="100%">Tamrin Talebe</style></author><author><style face="normal" font="default" size="100%">M. Faris</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Preconcenption Moringa Leaf Extract Supplementation on Cotinine Serum Levels in Pregnant Women Exposed to Tobacco Smoke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cotinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera.</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Tobacco smoke</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">290-293</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is known for its nutrition content, antioxidant and medical benefit. Tobacco smoke contains various toxic substance and can affect the pregnancy. To reduce the tobacco smoke effect on pregnancy outcome good nutrition is needed. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to assess the effect of Moringa leaf extract on serum cotinine levels in pregnant women exposed to second-hand tobacco smoke.&lt;strong&gt; Method:&lt;/strong&gt; This is an observational study with a prospective cohort study design the study population was pregnant women which were divided by 2 groups, first group received IFA supplements only (n = 30) and the second group receive IFA and Moringa leaf extract supplements (n = 26). The tobacco smoke exposure data collected with questionnaire, and cotinine serum by blood sample. The tobacco smoke exposure and cotinine serum levels were compered between the two groups.&lt;strong&gt; Results: &lt;/strong&gt;The tobacco smoke exposures at home were higher in MO+IFA group pregnant women then the IFA group pregnant women (p&amp;lt;0,05). The cotinine serum levels in both groups were found not significantly different (p=0,535). These results indicate that pregnant woman with high exposure of tobacco smoke who MO receive have similar cotinine serum levels with the pregnant woman with lower exposure of tobacco smoke. &lt;strong&gt;Conclusion:&lt;/strong&gt; Moringa leaf extract supplementation to pregnant women with high tobacco smoke exposure has serum cotinine levels similar to pregnant women with lower exposure to tobacco smoke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Haerani Harun&lt;sup&gt;1,*&lt;/sup&gt;, Anwar Daud&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, M Sabir&lt;sup&gt;4&lt;/sup&gt;, Veni Hadju&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;, Rahma&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;4&lt;/sup&gt;, Tamrin Talebe&lt;sup&gt;6&lt;/sup&gt;, M. Faris&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Enviromental Health, Public Health Faculty Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Microbiology,Medical faculty Tadulako University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Associate professor, Ushuluddin Faculty, Datokarama State Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irham Taufiqurrahman</style></author><author><style face="normal" font="default" size="100%">Siti Hajar Norma Gupita</style></author><author><style face="normal" font="default" size="100%">Beta Widya Oktiani</style></author><author><style face="normal" font="default" size="100%">Isyana Erlita</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Eko Suhartono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ramania Leaves Extract Gel (Bouea macrophylla  Griff) on the Number of Osteoblast (in vivo Study of Post  Extraction in Wistar Rats (Rattus norvegicus))</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bouea macrophylla Griff</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoblast</style></keyword><keyword><style  face="normal" font="default" size="100%">Ramania leaf extract gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary  metabolite</style></keyword><keyword><style  face="normal" font="default" size="100%">Tooth extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1219-1223</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ramania leaves extract contains secondary metabolite compounds such as flavonoids, steroids, phenols and terpenoids which can be used as an alternative medicine for socket wound healing. Flavonoids have anti-inflammatory and antioxidant properties that can accelerate wound healing and can stimulate the formation of osteoblasts. Analyzing the differences in the number of osteoblasts in the negative control group, positive control given aloe vera gel 15% and ramania leaf extract gel 15% on day 5, 7 and 14. This study used true experimental design with posttest-only control design, using 27 rats divide into 3 groups. The experimental animals were sacrificed on days 5, 7 and 14 for histopathological observations. Two-Way ANOVA test results obtained p value = 0.013 &amp;lt;0.05, which indicates that there is a significant difference between the use of 15% ramania leaf extract gel 15% and the number of osteoblasts on days 5, 7 and 14. Bonferroni's Post Hoc test showed a difference. The number of osteoblasts was significant among the negative control group with ramania leaf extract gel 15%. Ramania leaf extract gel 15% was proven to be able to increase the number of osteoblasts and has the potential as an alternative medicine for socket healing after tooth extraction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1219</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irham Taufiqurrahman&lt;sup&gt;1,2,&lt;/sup&gt;*, Siti Hajar Norma Gupita&lt;sup&gt;3&lt;/sup&gt; , Beta Widya Oktiani&lt;sup&gt;4&lt;/sup&gt; , Isyana Erlita&lt;sup&gt;5&lt;/sup&gt; , Andi Zulkifli&lt;sup&gt;6&lt;/sup&gt; , Veni Hadju&lt;sup&gt;6&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;6&lt;/sup&gt; , Eko Suhartono&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Periodontist, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Conservative Dentistry, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Departement of Medical Chemistry/ Biochemistry, Faculty of Medicine, Lambung Mangkurat University, Banjarbaru, South Kalimantan – INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darius Tandiabang</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Atjo Wahyu</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Safety Climate on Safety Behavior with Safety Motivation as An Intervening Variable on Contractor Workers in PT X</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Contractor workers</style></keyword><keyword><style  face="normal" font="default" size="100%">Path analysis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety behaviour</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety climate</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety motivation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">411-416</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Safety climate in the workplace and safety behaviour of workers need attention to be able to assess what factors are the causes of safe action for workers. This study aims to determine the effect of safety climate on safety behaviour with safety motivation as an intervening variable on contractor workers at PT X. The type of research is analytical observational with a cross sectional design. Questionnaires were given to 380 respondents. The data were analyzed using path analysis to see the direct and indirect effects of safety climate on safety behaviour. The results showed, 361 respondents (95%) with good safety climate, 367 respondents (96.9%) with good safety motivation, and 348 respondents (91%) with good safety behaviour. The path analysis showed that there was no direct influence of safety climate on safety behaviour in contractor workers at PT X (p value &amp;gt;0.05). However, the safety climate indirectly affects safety behaviour through safety motivation (p value = 0.001). It is recommended to workers that they need to maintain and increase their motivation so the safe work behaviour will still create.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">411</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darius Tandiabang&lt;sup&gt;1&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;1&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;1&lt;/sup&gt;, Atjo Wahyu&lt;sup&gt;1&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Occupational health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Environmental health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maspa Lapui</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Ida Leida Maria</style></author><author><style face="normal" font="default" size="100%">A Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Ridwan M Thaha</style></author><author><style face="normal" font="default" size="100%">Syamsuar Manyullei</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of SI-DINI Mobile App (an Education and Early Detection of Leprosy App) on Changes in Community Behavior</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Attitude</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior.</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Leprosy</style></keyword><keyword><style  face="normal" font="default" size="100%">SI-DINI App</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">868-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Most leprosy case detection in Indonesia is based on passive surveillance. This condition impacts the high number of new cases of leprosy and the disability rate of leprosy. Data from the Ministry of Health of the Republic of Indonesia stated that for 2021, there were 7,201 new cases of leprosy with a disability proportion of 84.6%. The community's reluctance to make early contact is due to low knowledge and fear of stigma. SI-DINI is an android-based application that contains information about leprosy, videos on identifying the characteristics and symptoms of leprosy, and reporting suspected leprosy so that it is hoped that it can change people's behavior in a positive direction. This study aims to see the effectiveness of the SI-DINI App in changing people's behavior. This study used a quasi-experimental design with a pre and post-test design with intervention and control groups. The use of the SI-DINI App has been proven effective in changing people's behavior in terms of knowledge, attitudes and actions. There is a significant increase in the knowledge aspect with&lt;em&gt; p&lt;/em&gt;-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05), the attitude aspect&lt;em&gt; p&lt;/em&gt;-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05), and the action aspect p-value = 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,05). It is hoped that the application of education and surveillance for early detection of leprosy (SI-DINI) can be applied on a broader scope and can be used sustainably and in the future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">868</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maspa Lapui&lt;sup&gt;1,*&lt;/sup&gt;, Wahiduddin&lt;sup&gt;1&lt;/sup&gt;, Ida Leida Maria&lt;sup&gt;1&lt;/sup&gt;, A Arsunan Arsin&lt;sup&gt;1&lt;/sup&gt;, Ridwan M Thaha&lt;sup&gt;2&lt;/sup&gt;, Syamsuar Manyullei&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ariunjargal Tudev</style></author><author><style face="normal" font="default" size="100%">Sansarkhuyag Enkhtur</style></author><author><style face="normal" font="default" size="100%">Khurelbaatar Luvsan</style></author><author><style face="normal" font="default" size="100%">Odontuya Gendaram</style></author><author><style face="normal" font="default" size="100%">Bold Sharav</style></author><author><style face="normal" font="default" size="100%">Ulambayar Lkhamsuren</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidating the Use of the Plant Paeonia Anomala from the Ancient  Medical Books Kept in Mongolia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1163-1165</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;It is important to determine and study in detail the action of the main chemical and secondary components contained in Paeonia anomala against diseases. In particular, it is of great practical significance to clarify the use of the plant from ancient medical books and scriptures and to determine which of the six main diseases were used in traditional medicine. &lt;strong&gt;Purpose&lt;/strong&gt;: To compare the information of the ancient medical books written by Mongolian doctors and scientists, who wrote about Paeonia anomala L. and to clarify the taste, potency, strength, and quality. &lt;strong&gt;Research materials and methods:&lt;/strong&gt; Research materials: Sumbe khamba Ishbaljir. “gso dpyad bdud rtsi 'i chu rgyun gyi cha lag gi nang tshan gyi sman so so'i mngon brjod dang ngos 'dzin shel dkar me long”. Wooden printing block with Tibetan script. Toin Jambaldorj. “gso byed bdud rtsi'i 'khrul med ngos 'dzin bzo rig me long du rnam par shar ba mdzes mtshar mig rgyan zhes bya ba bzhugs so”. Wooden printing block with Tibetan script. Research methods: Methods of textual analysis for ancient medical books and checklists were used in the study.&lt;strong&gt; Conclusion&lt;/strong&gt;: The use of Paeonia anomala has been enriched with indications for use in traditional Mongolian medicine, Mongolian folk medicine, Russian folk medicine, and Chinese, Japanese, and Korean traditional medicine. In his book &quot;ngos 'dzin shel dkar me long&quot;, the ancient medical scientist Sumbe khamba Ishbaljir wrote the name of the Paeonia anomala plant in Sanskrit as shogandha and in Tibetan as baspru. On the other hand, Toin Jambaldorj noted in his book &quot;mtshar mig rgyan&quot; wrote Paeonia anomala has a warm and equable quality, thus it can create potency. Therefore, it is appropriate to note that this plant in traditional Mongolian medicine is mainly used to treat back pain caused by cold conditions, chronic kidney disease, arthritis, uterine benign tumors, and bladder stones.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1163</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ariunjargal Tudev&lt;sup&gt;1&lt;/sup&gt; , Sansarkhuyag Enkhtur&lt;sup&gt;1&lt;/sup&gt; , Khurelbaatar Luvsan&lt;sup&gt;1&lt;/sup&gt; , Odontuya Gendaram&lt;sup&gt;1&lt;/sup&gt; , Bold Sharav&lt;sup&gt;1,2,*&lt;/sup&gt;, Ulambayar Lkhamsuren&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Mongolian University of Pharmaceutical Sciences, PO-37, Box-59, Ulaanbaatar 18080, Mongolia.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Mongolian Academy of Medical Science, Mongolian Academy of Sciences, PO-46A, Box-171, Ulaanbaatar 14201, Mongolia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sansarkhuyag Enkhtur</style></author><author><style face="normal" font="default" size="100%">Ariunjargal Tudev</style></author><author><style face="normal" font="default" size="100%">Tungalag Dagdanbazar</style></author><author><style face="normal" font="default" size="100%">Selenge Erdenechimeg</style></author><author><style face="normal" font="default" size="100%">Odontuya Gendaram</style></author><author><style face="normal" font="default" size="100%">Ulambayar Lkhamsuren</style></author><author><style face="normal" font="default" size="100%">Bold Sharav</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Elucidating the Uses of the Plant Veronica Incana from the Ancient Medical Books</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ancient medicinal books.</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional Mongolian medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Veronica Incana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">901-904</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Medicinal plant research has been successfully carried out in the field of pharmacy and pharmacology in Mongolia, and dozens of research projects are still being carried out. However, there are still fewer studied medicinal plants of practical importance growing in Mongolia. Therefore, there is a need to register and study the ancient medicinal books written by ancient Mongolian doctors about the relatively little-studied&lt;em&gt; Veronica Incana&lt;/em&gt; plant. In addition, taking into account that scientific research on &lt;em&gt;Veronica Incana,&lt;/em&gt; which grows in Mongolia, has not been done in the field of medicine. Therefore, the topic was selected for research in this field.&lt;strong&gt; Purpose:&lt;/strong&gt; Comparing the information of the ancient medical books written by Mongolian doctors and scientists, who wrote about&lt;em&gt; Veronica Incana,&lt;/em&gt; to clarify the taste, power, and quality. Research materials and methods: 1. &lt;strong&gt;Research materials:&lt;/strong&gt; Sumbe khamba Ishbaljir. gso dpyad bdud rtsi 'i chu rgyun gyi cha lag gi nang tshan gyi sman so so'i mngon brjod dang ngos 'dzin shel dkar me long. &lt;em&gt;Wooden printing block&lt;/em&gt; with&lt;em&gt; Tibetan&lt;/em&gt; script. Toin Jambaldorj. gso byed bdud rtsi'i 'khrul med ngos 'dzin bzo rig me long du rnam par shar ba mdzes mtshar mig rgyan zhes bya ba bzhugs so. &lt;em&gt;Wooden printing block&lt;/em&gt; with Tibetan script. 2. Research methods: Methods of textual analysis for ancient books and checklist methods were used in the study. &lt;strong&gt;Conclusion:&lt;/strong&gt; Gandhabhatra plant is used in traditional Mongolian medicinal practices from ancient times, the plant is called &lt;em&gt;Veronica Incana&lt;/em&gt; in Latin. Also called Buural gandbadraa in Mongolian. On the other hand, the traditional medical doctors of China's Inner Mongolia and Tibet use Gandbadraa, the Latin name Gnaphalium affine D. Don. The appearance, shape, and color of the flowers of these two plants are different. According to the research of the source, the main instruction and usage of the plants are the same: to destroy benign tumors, to remove poison, to treat colds, and to stop cough.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">901</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sansarkhuyag Enkhtur&lt;sup&gt;1&lt;/sup&gt;, Ariunjargal Tudev&lt;sup&gt;1&lt;/sup&gt;, Tungalag Dagdanbazar&lt;sup&gt;1&lt;/sup&gt;, Selenge Erdenechimeg&lt;sup&gt;1&lt;/sup&gt;, Odontuya Gendaram&lt;sup&gt;1&lt;/sup&gt;, Ulambayar Lkhamsuren1*, Bold Sharav&lt;sup&gt;1,2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Mongolian University of Pharmaceutical Sciences, PO-37, Box-59, Ulaanbaatar 18080, Mongolia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Mongolian Academy of Medical Science, Mongolian Academy of Sciences, PO-46A, Box- 171, Ulaanbaatar-14201, Mongolia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhairav Kumar Pathak</style></author><author><style face="normal" font="default" size="100%">Kamlesh M. Palandurkar</style></author><author><style face="normal" font="default" size="100%">Meenakshi Singh</style></author><author><style face="normal" font="default" size="100%">Anshuman Trigunayat</style></author><author><style face="normal" font="default" size="100%">Amit Singh</style></author><author><style face="normal" font="default" size="100%">Reena Giri</style></author><author><style face="normal" font="default" size="100%">Kiran Rajendra Giri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of In vivo Analgesic and Anti-inflammatory Activity of Oroxyulum indicum, Baicalein, Chrysin with Phytochemical Analysis and Molecular Docking Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baicalein</style></keyword><keyword><style  face="normal" font="default" size="100%">Chrysine</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Oroxylum indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF alpha.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">811-822</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: &lt;em&gt;Oroxyulum indicum &lt;/em&gt;(OIE) is a native medicinal plant that has been widely employed in Ayurvedic medicine for thousands of years. Though studies have been published citing the analgesic and anti-inflammatory activity of &lt;em&gt;Oroxyulum indicum&lt;/em&gt; and chrysin and Baicalein, there has been no comparative study comparing their activittes and confirming them with molecular docking results. Molecular docking study of two phytochemicals Chrysin (PubChem CID 5281607) and Baicalein (PubChem CID 5281605) into the active sites of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Evaluation and validation of Anti-inflammatory and Analgesic effects of a methanolic extract of the stem bark of Oroxylum indicum and its two constituents Chrysin and Baicalein in Charles foster rats with analysis of the phytoconstituent of &lt;em&gt;Oroxyulum indicum &lt;/em&gt;through HRMS analysis. &lt;strong&gt;Methodology: &lt;/strong&gt;UHPLC-HRMS/MS analyses were performed on a Dionex Ultimate 3000 RS Series UHPLC system combined with a Q Exactive Plus High-Resolution Accurate Mass Spectrometry System. Hot plate and Tal flick model are used for screening of analgesic activity. TNF-alpha and IL-6 inflammatory markers were examined. Carrageenan model is used for antiinflammatory analysis. &lt;strong&gt;Result: &lt;/strong&gt;Interesting results has been obtained in the docking studies of Chrysin and Baicalein with COX-1 (PDB ID: 1EQG). The hydrogen bond interaction established between the Chrysin and Baicalein with the important amino acid, includes Arg 120, Tyr 355, Ser 530, Met 522 (Figure 1). The binding free energy of the Chrysin and Baicalein with target COX-1 was found to be -7.88 and -7.26 Kcal/mol. &lt;strong&gt;Conclusion:&lt;/strong&gt; There is marked reduction in the TNF Alpha expression in the OIE group which is followed by Baicalein and Chrysine. The Baicalein group shows the most marked cumulative increase in reaction time for tail flick among all the groups of the intervention group followed by Chrysine and OIE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">811</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bhairav Kumar Pathak&lt;sup&gt;1&lt;/sup&gt;, Kamlesh M. Palandurkar&lt;sup&gt;2&lt;/sup&gt;, Meenakshi Singh&lt;sup&gt;3&lt;/sup&gt;, Anshuman Trigunayat&lt;sup&gt;4&lt;/sup&gt;, Amit Singh&lt;sup&gt;5&lt;/sup&gt;, Reena Giri&lt;sup&gt;6&lt;/sup&gt;, Kiran Rajendra Giri&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Junior Resident, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Biochemistry, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Medicinal Chemistry Department, Faculty of Ayurveda, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Pharmacology, GMC, Akola, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Pharmacology, IMS, BHU, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ns. Grace C Sipasulta</style></author><author><style face="normal" font="default" size="100%">Indah Nur Imamah</style></author><author><style face="normal" font="default" size="100%">Genevieva E Tanihatu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experiences and Expectations of Post-Partum Mothers Toward Psychosocial Nursing Services for Mothers Who Have Experienced Postpartum Blues in City of Balikpapan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baby Blues</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Postpartum</style></keyword><keyword><style  face="normal" font="default" size="100%">Psychosocial Services.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">471-478</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;After giving birth, the mother feels happy to finally be able to meet her beloved baby. However, some mothers actually do not feel happy but appear feelings of sadness, anxiety, and depression after giving birth. As many as 30-75 present of women can experience baby blues after giving birth and one in seven women can experience postpartum depression. Health Education needs to be improved and Nutrition for pregnant women needs attention Micronutrients prevent postpartum depression so that babies are born healthy. Based on the above problems that are still untouched by promotion and prevention health for women overcome the level of emotional anxiety from pregnancy to post-delivery which can be experienced by mothers from mild, moderate to severe. Nurses play a key role related to providing physical and psychological care to support the improvement of the mother's condition towards more positive. Mothers are at risk for natural emotional problems requiring someone to be able to give him an understanding of the process he is going through and help him to remain in a more stable condition. This study involved seven participants with diverse characteristics and provided an overview and the high need of postpartum mothers to feel comfortable so that their coping efforts could be achieved so that they did not experience emotional problems after giving birth.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">471</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ns. Grace C Sipasulta&lt;sup&gt;1&lt;/sup&gt;, Indah Nur Imamah&lt;sup&gt;1*&lt;/sup&gt;, Genevieva E Tanihatu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;East Kalimantan Health Polytechnic D-III Nursing Program Balikpapan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Univercity of Persada Indonesia Y.A.I, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ridwan Mochtar Thaha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Experimental Study of Development Food Safety Booklet using  Local Language</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Booklet</style></keyword><keyword><style  face="normal" font="default" size="100%">Cadre</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Safety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1132-1135</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;To prevent food poisoning in Indonesia, it is necessary to have health promotion efforts in the field of food safety using appropriate media. Therefore, this study aims to develop food safety information media, namely local language booklets. For this reason, this study examines the validity and feasibility of local language food safety booklet. The research was conducted in Gorontalo Province from August to October 2022. The development of booklet is done by validating and trial. Validation was carried out using the DELPHI technique with experts in a qualitative descriptive research type. After that, a trial of the booklet was carried out with 20 Village Food Safety Cadres by distributing trial questionnaires and short interviews. Data analysis in this study used content analysis techniques. The results of the validity and feasibility of the local language food safety booklet show that the booklet is very feasible to use. Furthermore, it is hoped that further research can examine the effectiveness of using booklets to convey food safety messages to the wider community.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1132</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ridwan Mochtar Thaha*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Health Promotion and Behavioral Science, Hasanuddin University of Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deviarbi Sakke Tira</style></author><author><style face="normal" font="default" size="100%">Sonyalin Buifena</style></author><author><style face="normal" font="default" size="100%">Sigit Purnawan</style></author><author><style face="normal" font="default" size="100%">Maria Magdalena Dwi Wahyuni</style></author><author><style face="normal" font="default" size="100%">Marni Marni</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Factors Affecting the Occurrence of Diarrhea in Infants Aged 7-12  Months in Puskesmas Alak Kupang City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BBLR</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">Exclusive breastfeeding</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunization Status</style></keyword><keyword><style  face="normal" font="default" size="100%">Premature</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1024-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Diarrhea is a disease characterized by changes in the consistency of stools to liquid accompanied by an increase in the frequency of defecation more than usual &amp;gt; 3 times / day accompanied by changes, with or without blood and or mucus. Factors that cause diarrheal disease are infections, infections can be caused by bacteria, parasites and viruses. Busy parents often pay less attention to health and the impact of an unhealthy environment. The three children have digestive problems, which are still considered a habit and can be cured without having to go to a health facility. The purpose of this study was to identify and analyze the factors that influence the incidence of diarrheal disease in infants aged 7-12 months at the Alak Health Center, Kupang City. The type of research used is an analytical survey with a case control design. The population in this study was divided into case populations, namely all infants aged 7-12 months totaling 137 infants and controls were infants aged 7-12 months who did not experience diarrhea totaling 8,868 infants. Determination of the size of the control sample using a ratio of 1:1 with the case sample so that the number of control samples is the same as the case sample, namely 37 infants and the total sample is 74 infants. The sampling technique is simple random sampling. Analysis of the data used is the chisquare test. The results showed that there was a significant relationship with a history of premature birth (p-value = 0.015 with an odds ratio = 3.434), low birth weight (p-value = 0.015 with an odds ratio = 4.563), exclusive breastfeeding (p-value = 0.015 with an odds value ratio = 3.434), immunization status (p-value = 0.004 with odds ratio = 4.265) and history of allergies (p-value = 0.004 with odds ratio = 4.083) with the incidence of diarrheal disease at the Alak Health Center, Kupang City. Suggestions that health center health workers need to be able to increase prevention efforts from an early age by approaching the community and providing concrete education related to the incidence of diarrhea.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1024</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Deviarbi Sakke Tira&lt;sup&gt;1,&lt;/sup&gt;*, Sonyalin Buifena&lt;sup&gt;1 &lt;/sup&gt;, Sigit Purnawan&lt;sup&gt;1&lt;/sup&gt; , Maria Magdalena Dwi Wahyuni&lt;sup&gt;1&lt;/sup&gt; , Marni Marni&lt;sup&gt;1&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Science, Faculty of Public Health, Nusa Cendana University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yuniarti</style></author><author><style face="normal" font="default" size="100%">Rusmilawaty</style></author><author><style face="normal" font="default" size="100%">Tri Tunggal</style></author><author><style face="normal" font="default" size="100%">Norlaila Sofia</style></author><author><style face="normal" font="default" size="100%">Nur Rohmah Prihatanti</style></author><author><style face="normal" font="default" size="100%">Ahmad Rizani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunization During the Covid-19 Pandemic</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Accessibility</style></keyword><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Center</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunization</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1005-1009</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This Study Aims to Analyze the Determinant Factors Associated with Basic Immunization Services for Infants Aged 1-12 Months in Banjarbaru City During the Covid 19 Pandemic. &lt;strong&gt;Methods:&lt;/strong&gt; The Research Design Is an Analytic Research with A Cross Sectional Approach. The Independent Variables Are Mother's Knowledge, Mother's Anxiety, And Accessibility to Health Facilities, And the Dependent Variable Is Basic Immunization Services. The Research Sample Consisted Of 100 Respondents Who Had Babies Aged 1-12 Months in The Cempaka Health Center, Sungai Ulin Health Center, Sungai Besar Health Center and South Banjarbaru Health Center. The Sampling Technique Was Non-Probability Sampling, Namely Purposive Sampling. The Instruments Used Were A Knowledge Questionnaire, An Anxiety Questionnaire (Dass) And an Accessibility Questionnaire in The Form of a Google Form. Analysis Using the Chi Square Statistical Test. &lt;strong&gt;Results: &lt;/strong&gt;The Results Showed That 58 People (58.0%) Had Basic Immunization Services According to Age, 44 People (44.0%) Had Good Knowledge And 55 People (55.0%) Had Accessibility to Health Facilities. Variables Related to Basic Immunization Services in Banjarbaru City Were Knowledge (P=0.03) And Anxiety (P=0.01). Another Variable in This Study, That Is Accessibility to Health Services, Was Not Related to Basic Immunization Services in Banjarbaru City (P=0.80). &lt;strong&gt;Conclusions:&lt;/strong&gt; It Is Recommended That Basic Immunization Information and Services Be More Proactive. Health Promotion Uses an Interpersonal Approach in The Community to Increase Knowledge, Attitudes and Change People's Behavior.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1005</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yuniarti&lt;sup&gt;1,&lt;/sup&gt;*, Rusmilawaty&lt;sup&gt;1&lt;/sup&gt; , Tri Tunggal&lt;sup&gt;1&lt;/sup&gt; , Norlaila Sofia&lt;sup&gt;1 &lt;/sup&gt;, Nur Rohmah Prihatanti&lt;sup&gt;1&lt;/sup&gt; , Noor Adha Aprilea&lt;sup&gt;1&lt;/sup&gt; , Ahmad Rizani&lt;sup&gt;1&lt;/sup&gt; , Anwar mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Midwifery Departement, Ministry of Health Republic of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of public health, University of Hasanuddin, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Fauzan Jauhari</style></author><author><style face="normal" font="default" size="100%">Lucia Yovita Hendrati</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author><author><style face="normal" font="default" size="100%">Asra Al Fauzi</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Eko Agus Subagio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Impact of Kaempferia galanga L. Extract on Nerve Growth  Factor Expression in A Rat Model of Traumatic Brain Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">kaempferia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Nerve Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1236-1243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Head injuries contribute significantly to morbidity and mortality globally, and there is need of effective treatment. This study focuses on evaluating NGF (Nerve Growth Factor) expression in a rat model of traumatic brain injury, exploring the potential therapeutic effects of &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract. &lt;strong&gt;Methods: &lt;/strong&gt;Male Wistar rats were used in the experiment, and traumatic brain injury was induced using Marmarou's weight drop model. Four groups of rats were studied: a negative control group, a group with traumatic brain injury without &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract, and two groups with traumatic brain injury treated with different doses of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. Rats were divided further based on the time of decapitation, either 24 or 48 hours post-injury. NGF expression was assessed using immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; The study confirmed NGF expression variations among groups, with stronger expression observed 48 hours post-injury in rats receiving 1200 mg/kgbb of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. This suggests a potential impact of the extract on NGF expression, likely attributed to its anti-inflammatory and antioxidant properties. &lt;strong&gt;Discussion:&lt;/strong&gt; &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract has known anti-inflammatory and antioxidant effects, which may contribute to increased NGF expression observed in this study. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study sheds light on the potential benefits of&lt;em&gt; Kaempferia galanga L&lt;/em&gt;. extract in promoting NGF expression and improving outcomes in traumatic brain injury, emphasizing the need for further investigation to translate these findings into clinical practice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1236</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Fauzan Jauhari&lt;sup&gt;1&lt;/sup&gt; , Lucia Yovita Hendrati&lt;sup&gt;2 *&lt;/sup&gt;, Agus Turchan&lt;sup&gt;1 &lt;/sup&gt;, Asra Al Fauzi&lt;sup&gt;1&lt;/sup&gt; , Budi Utomo&lt;sup&gt;3&lt;/sup&gt; , Eko Agus Subagio&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Population Biostatistics and Health promotion, Faculty of Public Health, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Brajakson Siokal</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Tahir Abdullah</style></author><author><style face="normal" font="default" size="100%">Yuliana Syam</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Hasnawati Amqam</style></author><author><style face="normal" font="default" size="100%">Rian Adi Pamungkas</style></author><author><style face="normal" font="default" size="100%">Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Samsualam</style></author><author><style face="normal" font="default" size="100%">Sudarman</style></author><author><style face="normal" font="default" size="100%">Akbar Asfar</style></author><author><style face="normal" font="default" size="100%">Andi Mappanganro</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Improving the Quality of Assessment and Diagnosis in Nursing Care: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">703-706</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Nursing care involves a series of interactions between nurses with clients and the environment to meet their needs and ensure independence in caring for themselves. Therefore, this research aimed to examine how to improve the quality of assessments and diagnoses in nursing care. Several articles were obtained from Google Scholar, Pubmed, and ProQuest databases, while the research questions were structured using the PICO method and search keywords. The inclusion criteria included articles focused on the quality of assessments and diagnoses in nursing care, applied to health institutions and services, and published in English from 2018-2022. A total of six articles were included after thorough identification, screening, eligibility, and inclusion. The results obtained can be used to improve the quality of assessments and diagnoses in nursing care.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">703</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Brajakson Siokal&lt;sup&gt;1,*&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, Tahir Abdullah&lt;sup&gt;2&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;2&lt;/sup&gt;, Yuliana Syam&lt;sup&gt;2&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Hasnawati Amqam&lt;sup&gt;2&lt;/sup&gt;, Rian Adi Pamungkas&lt;sup&gt;3&lt;/sup&gt;, Wahyuningsih&lt;sup&gt;4&lt;/sup&gt;, Samsualam&lt;sup&gt;1&lt;/sup&gt;, Sudarman&lt;sup&gt;1&lt;/sup&gt;, Akbar Asfar&lt;sup&gt;1&lt;/sup&gt;, Andi Mappanganro&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universitas Muslim Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universitas Esa Unggul, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universitas Patria Artha, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Brajakson Siokal</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Tahir Abdullah</style></author><author><style face="normal" font="default" size="100%">Yahya Thamrin</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Erniwati Ibrahim</style></author><author><style face="normal" font="default" size="100%">Yuliana Syam</style></author><author><style face="normal" font="default" size="100%">Rian Adi Pamungkas</style></author><author><style face="normal" font="default" size="100%">Samsualam</style></author><author><style face="normal" font="default" size="100%">Andi Mappanganro</style></author><author><style face="normal" font="default" size="100%">Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Influence of Effective Nurse Communication Application on Patient Satisfaction: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Effective communication</style></keyword><keyword><style  face="normal" font="default" size="100%">Nurses</style></keyword><keyword><style  face="normal" font="default" size="100%">Patient satisfaction.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">479-483</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Communication is an important element for building trust and comfort in nursing, and it is the foundation of the nurse-patient relationship. The purpose of this study is to find out how effective communication influences nurses' perceptions of patient satisfaction. A recent literature review was conducted using the Pubmed, Wiley Online, and Science Direct electronic databases. The review method uses the terms and expressions of the keywords &quot;effective communication,&quot; &quot;nurse,&quot; and &quot;patient satisfaction.&quot; Based on the screening results for inclusion and exclusion criteria, a literature search turned up 10 studies. Effective communication provided by nurses greatly affects patient satisfaction; the better effective communication is carried out, the greater the patient satisfaction will be. With patient satisfaction, nurse communication can improve service by creating good cooperative relationships and fostering trust so as to improve patient recovery. Not only with patients, but effective communication must also be carried out with colleagues and other professions by applying several methods such as ISBAR, PCC, and MCA communication methods. Therefore, health services, especially nurses, should pay more attention to effective communication with patients and implement this effective communication in nursing care activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">479</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Brajakson Siokal&lt;sup&gt;1,2,*&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, Tahir Abdullah&lt;sup&gt;3&lt;/sup&gt;, Yahya Thamrin&lt;sup&gt;4&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;5&lt;/sup&gt;, Erniwati Ibrahim&lt;sup&gt;6&lt;/sup&gt;, Yuliana Syam&lt;sup&gt;7&lt;/sup&gt;, Rian Adi Pamungkas&lt;sup&gt;8&lt;/sup&gt;, Samsualam&lt;sup&gt;9&lt;/sup&gt;, Andi Mappanganro&lt;sup&gt;9&lt;/sup&gt;, Wahyuningsih&lt;sup&gt;10&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;10&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nursing, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of the Health Policy and Administration, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Departement of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Nursing, Faculty of Health Science, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Nursing, Faculty of Health Science, Esa Unggul of University, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Nursing, Faculty of Public Health, Universitas Muslim Indonesia, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Nursing, Faculty of Nursing Science, Universitas Patria Artha, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sucharat Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Runtikan Pochairach</style></author><author><style face="normal" font="default" size="100%">Aungkana Krajarng</style></author><author><style face="normal" font="default" size="100%">Piracha Jumpa-ngern</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Investigation of The Network Pharmacology and Mechanism of Action of Centella Asiatica Extract on The Atopic Dermatitis Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atopic dermatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">Network pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin inflammation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">881-890</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Atopic dermatitis (AD) is a chronic relapsing inflammatory skin condition which has a negative impact on children health. The well-known medicinal plant Centella asiatica extract (CE) is used in herbal skin care products to produce various pharmacological effects in dermatology. However, the molecular target of CE in suppressing inflammatory is largely unknown. &lt;strong&gt;Objective&lt;/strong&gt;: the aim of this study was to examine anti-inflammatory properties and network pharmacology of CE in lipopolysaccharide (LPS)- induced AD &lt;em&gt;in vitro&lt;/em&gt; model.&lt;strong&gt; Method:&lt;/strong&gt; RAW264.7 cells were pre-treated with CE and then were stimulated with LPS and then were investigated cell viability, NO production, and the levels of pro-inflammatory mediators. In addition, the Search Tool for Retrieval of Interacting Genes (STRING), SwissTargetPrediction and the Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to construct the defined mechanism of action and network pharmacology. &lt;strong&gt;Results:&lt;/strong&gt; CE showed the potent inhibitory effects on LPS-induced NO. In addition, CE significantly suppressed the expression of iNOS and COX-2, as well as the production of IL-2, IL-6, IL-10, and TNF- α. Furthermore, the network pharmacological analysis revealed the potential role of CE in biological processes such as regulating JAK/STATs pathway and inhibiting proinflammatory cytokines both of which were linked to AD pathogenesis. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings confirm our hypothesis that CE could be developed as a therapeutic therapy for atopic dermatitis due to its pharmacological action and signaling mechanism in the modulation of allergic skin inflammation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">881</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sucharat Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Runtikan Pochairach&lt;sup&gt;2&lt;/sup&gt;, Aungkana Krajarng&lt;sup&gt;3&lt;/sup&gt;, Piracha Jumpa-ngern&lt;sup&gt;3&lt;/sup&gt;, Parunkul Tungsukruthai&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Thammasat University Research Unit in Mechanisms of Drug Action and Molecular Imaging, Drug Discovery and Development Center, Office of Advanced Science and Technology, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Chulabhorn International College of Medicine Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ernyasih</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Anwar Daud</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Stang</style></author><author><style face="normal" font="default" size="100%">Razak Thaha</style></author><author><style face="normal" font="default" size="100%">Erniwaty Ibrahim</style></author><author><style face="normal" font="default" size="100%">Wesam Al Moudhun</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Model Prediction of Potential Disease Effects from PM2.5 Emission Among School Children in Coming 30 years in South Tangerang</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute respiratory infection.</style></keyword><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Particulate matter</style></keyword><keyword><style  face="normal" font="default" size="100%">Transportation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">400-404</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The largest global environmental health risk factor is the ambient of air pollution, that largely attributed to transportation emissions. One of the main causes of PM&lt;sub&gt;2.5&lt;/sub&gt; emissions is thought to be onroad transportation. PM&lt;sub&gt;2.5 &lt;/sub&gt;has an impact on health, especially on children that relate to the respiratory system such as asthma, lung cancer, and decreased intelligence. &lt;strong&gt;Objective:&lt;/strong&gt; The research objective was to predict the risk potential disease due to PM2.5 in children from vehicle emissions in South Tangerang City. &lt;strong&gt;Method:&lt;/strong&gt; This research is an observational analytic study with a cross-sectional study design using a dynamic model approach using STELLA software. The environmental and human samples aare used to calculate the exposure level to PM&lt;sub&gt;2.5&lt;/sub&gt; taken from 32 points in 7 sub-districts of South Tangerang City (North Serpong, Serpong, Pondok Aren, Ciputat, East Ciputat, Pamulang, and Setu). then, meteorological data was also collected. &lt;strong&gt;Results:&lt;/strong&gt; The number of vehicles in the city of South Tangerang is quite high, especially between 11:00 and 15:00 with the majority of vehicles passing by are cars and motorbikes. PM&lt;sub&gt;2.5&lt;/sub&gt; pollution levels will fluctuate until 2053. The effects of temperature, weather, and humidity might cause an increase in PM&lt;sub&gt;2.5&lt;/sub&gt; pollutants at specific times. According to the modeling calculation results, even though there are occasions when PM&lt;sub&gt;2.5&lt;/sub&gt; pollution levels fall, acute respiratory infection (ARI) incidence in children will continue to rise over time. Although PM&lt;sub&gt;2.5 &lt;/sub&gt;emissions fluctuate, exposure to PM&lt;sub&gt;2.5&lt;/sub&gt; in low concentrations poses a risk to human health.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">400</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ernyasih&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2,*&lt;/sup&gt;, Anwar Daud&lt;sup&gt;2&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;3&lt;/sup&gt;, Stang&lt;sup&gt;4&lt;/sup&gt;, Razak Thaha&lt;sup&gt;5&lt;/sup&gt;, Erniwaty Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Wesam Al Moudhun&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Postgraduate Program, Faculty of Public Health, Hasanuddin University, Faculty of Public Health, Universitas Muhammadiyah Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Health Department, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Policy and Administration, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Population, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Community Nutrition Study Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Environmnetal Health Department, Faculty of Public Health, Gaza University, PALESTINE.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Julio Luis Díaz-Uribe</style></author><author><style face="normal" font="default" size="100%">María Elena Salazar-Salvatierra</style></author><author><style face="normal" font="default" size="100%">Julio Reynaldo Ruiz-Quiroz</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera- Calderon</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Freddy Emilio Tataje-Napuri</style></author><author><style face="normal" font="default" size="100%">José Francisco Kong-Chirinos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Profile, Antioxidant and Antibacterial Activity of the Essential Oil of Luma Chequen (Molina) A. Gray from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Aromatic plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Luma chequeen</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">777-780</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Luma chequen belongs to Myrtaceae family and it is known as “arrayan”. In the traditional medicine from Peru, L chequen is used as aromatic plant, anti-inflammatory and hypocholesterolemic. Objective: To determine the phytochemical profile, evaluate the antioxidant and the antibacterial activity of &lt;em&gt;L. chequen&lt;/em&gt; essential oil. &lt;strong&gt;Material and Methods&lt;/strong&gt;: In the analysis of the volatile components a Gas Chromatography coupled to Mass Spectrometry (GC-MS) was used to identify the content of terpenes and sesquiterpenes. 2,2-diphenyl-1-picrylhydrazyl (DPPH) was the method used to determine the antioxidant activity and obtain the half inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;). For the antibacterial activity, a colorimetric macrodilution method was carried out to evaluate the effect of the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC 25923 and Escherichia coli ATCC 25922. &lt;strong&gt;Results:&lt;/strong&gt; The analysis by GC-MS showed two major components alpha-pinene (62.89%) followed by 1,8-cineole (11.94%), and propanoic acid, 2-methyl-, 2-methylpropyl ester with 8.67%. In the antioxidant activity against DPPH radical, the essential oil of &lt;em&gt;L. chequen&lt;/em&gt; showed an IC&lt;sub&gt;50&lt;/sub&gt; equivalent to124.60 ± 2.0 μg/mL. In the antibacterial activity, &lt;em&gt;L. chequen&lt;/em&gt; had an MIC (minimum inhibitory concentration) for &lt;em&gt;Staphylococcus aureus &lt;/em&gt;ATCC 25923 and Escherichia coli ATCC 25922 of 4.35 ± 0 μg/mL and 8.71 ± 0 μg/mL respectively. &lt;strong&gt;Conclusion&lt;/strong&gt;: &lt;em&gt;L. chequen &lt;/em&gt;presented monoterpene compounds as main phytoconstituents as well as antioxidant and antibacterial activity in vitro. The essential oil might be used as antimicrobial agent in the future overall against S. aureus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">777</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Julio Luis Díaz-Uribe&lt;sup&gt;1&lt;/sup&gt;, María Elena Salazar-Salvatierra&lt;sup&gt;2&lt;/sup&gt;, Julio Reynaldo Ruiz-Quiroz&lt;sup&gt;2&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3,*&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;4&lt;/sup&gt;, Freddy Emilio Tataje- Napuri&lt;sup&gt;5&lt;/sup&gt;, José Francisco Kong- Chirinos&lt;sup&gt;6&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Basic and Applied Chemistry Department, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute for Research in Biological Chemistry, Microbiology and Biotechnology “Marco Antonio Garrido Malo”, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departamento de Ciencias Comunitarias, Facultad de Odontología, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Surgical Clinical Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Idowu</style></author><author><style face="normal" font="default" size="100%">Olajumoke Tolulope</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antibacterial Activity and Fatty Acids from Heliotropium Indicum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas-Chromatography Mass Spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Heliotropium indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">350-352</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Heliotropium indicum &lt;/em&gt;are used in ethnomedicine for treating skin rashes, inflammation, tumors and various diseases of microbial origin. Previous work focused on phytochemical constituents, antibacterial activities and isolated compounds. The whole plant was air dried and pulverized (600 g). It was extracted with ethanol and concentrated to dryness in &lt;em&gt;vacuo&lt;/em&gt; (20 g). Screening for phytochemical groups was performed using qualitative methods. The antibacterial activity was performed using agar diffusion and antifungal activity using ditch plate method. Compounds were characterized using Gas-chromatography Mass Spectrometry. The results of the phytochemical screening revealed the presence of phenols, saponins, terpenoids and cardiac glycosides. The results further showed the crude extract of the plant to be moderate to strong antibacterial activity with zones of inhibition ranging from 12.0 + 1.6 mm and 25 +1.7 mm. the crude extracts of &lt;em&gt;Heliotropium indicum&lt;/em&gt; demonstrated antibacterial properties which confirmed the traditional use of this plant in treating skin rashes and boil. In addition, the presence of Palmitate and Linoleic acid I the plant as revealed in this study justified the use of this plant in treating hypertension.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">350</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Idowu, Olajumoke Tolulope*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemical Sciences, Industrial Chemistry Program, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asmaa Y Thanoon</style></author><author><style face="normal" font="default" size="100%">Faehaa Azher Al-Mashhadane</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in  Periodontitis: A Clinical Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CYP27</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytochrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodontitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1112-1115</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Vitamins have a great impact on metabolis. &lt;strong&gt;Aims: &lt;/strong&gt;To determine the role of 1,25(OH)2D On Cytochromes CYP27A1 and CYP27B1 in Periodontitis. &lt;strong&gt;Material and Method:&lt;/strong&gt; The investigation was carried out on 45 participants of ages within the range of (30-45 years) who were attending the private dental clinics. Diagnosis of chronic periodontitis was established depending on dental history, clinical examinations (periodontal indices). All participants were examined by the same dentist. They were classified into three groups: Group 1 (control negative): (15) participants with normal serum vitamin D3 level and with pocket depth ≤3 mm, good oral health and normal periodontal tissues and no previous history of periodontal diseases. Group 2 (control positive): (15) participants with normal serum vitamin D3 level and periodontitis with pocket depth ≥5 mm, they received placebo medication orally, Group3(treatment): (15) participants with vitamin D3 deficiency (below 30 IU), and periodontitis with pocket depth ≥5 mm, they received oral Vitamin D3 fast acting liquid soft gel capsule 2000 IU /day for 3 months. 3 blood samples were taken from each participant at 0,45,90 days, for research examinations. CYP27A1, CYP27B1 serum levels was measured for each sample in three groups by ELISA kit. &lt;strong&gt;Result:&lt;/strong&gt; there was a highly significant reduction in CYP27A1 serum level in the treatment group at the ninety days of the study while there was no significant elevation CYP27B1 serum level in all groups during 45,90 days of the study. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study suggested that the 1,25(OH)2D has effects on serum levels of both Cytochromes CYP27A1 and CYP27B1 and this was associated with periodontitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1112</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Asmaa Y Thanoon*, Faehaa Azher Al-Mashhadane&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Dental Basic Sciences, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patnaree Wongmanit</style></author><author><style face="normal" font="default" size="100%">Parunkul Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Pratya Phetkate</style></author><author><style face="normal" font="default" size="100%">Daraporn Rungprai</style></author><author><style face="normal" font="default" size="100%">Sucharat Tungsukruthai</style></author><author><style face="normal" font="default" size="100%">Ouppatham Supasyndh</style></author><author><style face="normal" font="default" size="100%">Kusuma Sriyakul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Safety Assessment of Supplementation with Cymbopogon citratus Stapf. (Lemongrass) Extract in Patients with Chronic Kidney Disease Stage 3: A Preliminary 90-Days Prospective Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chronic Kidney Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">CKD stage 3</style></keyword><keyword><style  face="normal" font="default" size="100%">Cymbopogon citratus Stapf.</style></keyword><keyword><style  face="normal" font="default" size="100%">Lemongrass</style></keyword><keyword><style  face="normal" font="default" size="100%">Safety</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">976-986</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Chronic kidney disease is a major public health issue, and due to resource constraints, many can't access dialysis. &lt;em&gt;C. citratus&lt;/em&gt;, lemongrass is globally prevalent and known to increase urine output without toxicity.&lt;strong&gt; Objective:&lt;/strong&gt; To examine the safety of &lt;em&gt;C. citratus&lt;/em&gt; in patients with CKD stage 3. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The major compound of &lt;em&gt;C. citratus&lt;/em&gt; was analyzed using high-performance liquid chromatography (HPLC). 64 patients were enrolled and randomly assigned to control or &lt;em&gt;C. citratus&lt;/em&gt; groups. The control group received a placebo, whereas the &lt;em&gt;C. citratus&lt;/em&gt; group received 900 mg of &lt;em&gt;C. citratus&lt;/em&gt; daily for 90 days. All participants were examined BUN, Scr, Cys-C, and eGFR, liver functions, RBC, HCT, Na+, K+, Cl-, and HCO3, and other biochemical parameters. &lt;strong&gt;Results:&lt;/strong&gt; HPLC showed &lt;em&gt;C. citratus&lt;/em&gt; contains of phenolic compounds. Clinically, &lt;em&gt;C. citratus &lt;/em&gt;group had no notable side effects on T-Bil, AST, ALT and ALP. Also, maintained eGFR, SCys-C, K+ and Cl level. The level of blood Na+ was significant increase at day 30 (p &amp;lt; 0.05). The control group had a significant decrease in eGFR and HCO3 levels (p &amp;lt; 0.05) and a significant increase of Cl- and SCys-C. In addition, no statistical differences had found between groups in eGFR, BUN, Cr, Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;, HCO3, PO4, RBC and HCT levels. Throughout the 90 days, no drug allergies or side effects were reported. &lt;strong&gt;Conclusion:&lt;/strong&gt; Dietary supplementation with &lt;em&gt;C. citratus&lt;/em&gt; may have a favorable effect on delaying the course of CKD and is safe to use for patients with CKD stage 3.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">976</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Patnaree Wongmanit&lt;sup&gt;1&lt;/sup&gt;, Parunkul Tungsukruthai&lt;sup&gt;1&lt;/sup&gt;, Pratya Phetkate&lt;sup&gt;1&lt;/sup&gt;, Daraporn Rungprai&lt;sup&gt;2&lt;/sup&gt;, Sucharat Tungsukruthai&lt;sup&gt;3&lt;/sup&gt;, Ouppatham Supasyndh&lt;sup&gt;4&lt;/sup&gt;, Kusuma Sriyakul&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Silpakorn University (Sanamchandra Palace Campus), Nakhon Pathom, 73000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Health and Applied Sciences, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Kasetsart University, Chatuchak, Bangkok 10900, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Wilfredo Bulege-Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Luz Alexandra Javier-Silva</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre- Meza</style></author><author><style face="normal" font="default" size="100%">Victor Guillermo Sanchez-Araujo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Tanacetum parthenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">435-437</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Tanacetum parthenium&lt;/em&gt; (L.) Sch Bip known as “santa maría” (&lt;em&gt;Asteraceae&lt;/em&gt; family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. &lt;strong&gt;Objective:&lt;/strong&gt; The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of &lt;em&gt;T. parthenium &lt;/em&gt;&lt;strong&gt;Material and Methods:&lt;/strong&gt; Leaves and flowers of &lt;em&gt;T. parthenium&lt;/em&gt; were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method.&lt;strong&gt; Results:&lt;/strong&gt; Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC&lt;sub&gt;50 &lt;/sub&gt;showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. &lt;strong&gt;Conclusions:&lt;/strong&gt; The ethanolic extract of flowers of &lt;em&gt;T. parthenium &lt;/em&gt;showed a high antioxidant activity and antinociceptive effect in mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Wilfredo Bulege-Gutiérrez&lt;sup&gt;2&lt;/sup&gt;, Luz Alexandra Javier-Silva&lt;sup&gt;3&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;4&lt;/sup&gt;, Victor Guillermo Sanchez-Araujo&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;7&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;8&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Privada del Norte, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Peruana Los Andes, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Huancavelica, PERU. 6Department of Chemical Sciences, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Human Medicine, Faculty of Health Science, Universidad Nacional de San Cristobal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Chemistry Pharmaceutical, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ponco Birowo</style></author><author><style face="normal" font="default" size="100%">Nurhuda Sahar</style></author><author><style face="normal" font="default" size="100%">R. Muharam</style></author><author><style face="normal" font="default" size="100%">Dwi Ari Pujianto</style></author><author><style face="normal" font="default" size="100%">Rosalina Thuffi</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Conny Riana Tjempakasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of LH Receptor Expression in the Testes of Infertile Azoospermic Non-Obstructive (NOA) Men at High Serum Prolactin Concentrations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hyperprolactinemia</style></keyword><keyword><style  face="normal" font="default" size="100%">LH receptor expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Male infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Non obstructive azoospermia (NOA).</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">462-468</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hyperprolactin is one of the endocrine disorders that causes male infertility (11%). The mechanism is not widely known; it is thought to occur through disruption of LH receptor activity on germ cells. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of study to compare the level of prolactin secretion with receptor expression in non-azoospermic infertile men (NOA). &lt;strong&gt;Methods&lt;/strong&gt;: During the period from July 2019 to July 2021, 40 samples of testicular tissue and serum were obtained from infertile NOA men, aged 25-50 years who were recruited from Ciptomangunkusumo Hospital (RSCM) Jakarta, Faculty of Medicine, Universitas Indonesia and Bunda Hospital Jakarta. Subjects were divided into 4 groups based on prolactin levels (20 ng/ml, 20-50 ng/ml, 50-100 ng/ml and 100ng/ml). This group was tested for significance between groups and continued with a correlation test with the level of LH receptor expression. &lt;strong&gt;Results&lt;/strong&gt;: ANOVA test showed a significant decrease in LH receptor expression between prolactin levels &amp;lt; 20 ng/mL with levels of 50-100 ng/ml and prolactin levels &amp;gt; 100 ng/ml (P &amp;lt; 0.05). Furthermore, the results of the correlation test showed a significant decrease between prolactin levels and LH receptor expression (P &amp;lt; 0.05). &lt;strong&gt;Conclusion&lt;/strong&gt;: The higher the level of prolactin secretion in this sample, there is a decrease in LH receptor expression, so that testosterone production decreases and the spermatogenesis process will be disrupted.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">462</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ponco Birowo&lt;sup&gt;1&lt;/sup&gt;, Nurhuda Sahar&lt;sup&gt;2&lt;/sup&gt;, R. Muharam&lt;sup&gt;3&lt;/sup&gt;, Dwi Ari Pujianto&lt;sup&gt;2&lt;/sup&gt;, Rosalina Thuffi&lt;sup&gt;4&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;5-8,*&lt;/sup&gt;, Conny Riana Tjempakasari&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Urology, Faculty of Medicine, Universitas Indonesia Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Magister Program Biomedical sciences, Faculty of Medicine, Universitas Indonesia Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Microbiology Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Duc Minh Nguyen</style></author><author><style face="normal" font="default" size="100%">Quang Canh Tran</style></author><author><style face="normal" font="default" size="100%">Minh Trung Do</style></author><author><style face="normal" font="default" size="100%">Duc Thinh Pham</style></author><author><style face="normal" font="default" size="100%">Thi Hong Hanh Le</style></author><author><style face="normal" font="default" size="100%">Duy Bac Nguyen</style></author><author><style face="normal" font="default" size="100%">Van Thu Nguyen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Ulcer Activity of Spray-dried Powders Prepared from Aerial Parts Extracts of Ampelopsis cantoniensis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ampelopsis cantoniensis</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Spray drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">276-281</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Ampelopsis cantoniensis &lt;/em&gt;is called “Che day” in Vietnam and has been used as a traditional treatment for inflammatory diseases. &lt;strong&gt;Methods: &lt;/strong&gt;Plant material and hydroalcoholic extract were processed and analyzed for their physicochemical characteristics. A method using HPLC was validated to quantify ampelopsin. Hydroalcoholic extract was spray dried and the powder obtained was characterized in terms of its physicochemical parameters and potential for antiulcerogenic activity. &lt;strong&gt;Results: &lt;/strong&gt;The analytical method proved to be selective, linear, accurate, sensitive. &lt;em&gt;A. cantoniensiss&lt;/em&gt; pray dried extract (ACP) was obtained using colloidal silicon dioxide as adjuvant and was shown to possess 25.94 % ampelopsisn. It showed significant antiulcer activity in a model of an indomethacin-induced gastric lesion in rats and also produced a gastroprotective effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">04</style></accession-num><section><style face="normal" font="default" size="100%">276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Duc Minh Nguyen&lt;sup&gt;1#&lt;/sup&gt;, Quang Canh Tran&lt;sup&gt;2#&lt;/sup&gt;, Minh Trung Do&lt;sup&gt;3&lt;/sup&gt;, Duc Thinh Pham&lt;sup&gt;3&lt;/sup&gt;, Thi Hong Hanh Le&lt;sup&gt;3&lt;/sup&gt;, Duy Bac Nguyen&lt;sup&gt;3&lt;/sup&gt;,*,Van Thu Nguyen&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Traditional Medicine &amp;amp; Pharmacy Development and Application, National Hospital of Acupuncture, 49 Thai Thinh, Dong Da District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt; Haiduong Medical Technical University, No 1 Vu Huu street, Thanh Binh ward, Hai Duong city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Vietnam Military Medical University, 160 Phung Hung, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;Authors contributed equally&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paul Alan Arkin Alvarado-García</style></author><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Luis Enrique Rosales-Cerquin</style></author><author><style face="normal" font="default" size="100%">Elda Maritza Rodrigo-Villanueva</style></author><author><style face="normal" font="default" size="100%">Demetrio Rafael Jara-Aguilar</style></author><author><style face="normal" font="default" size="100%">Lurdes Tuesta-Collantes</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anxiolytic and Antidepressant-like Effects of Foeniculum vulgare Essential Oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Foeniculum vulgare</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">425-431</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: The aim of this research was to determine the anxiolytic and antidepressant-like effects of the essential oils from &lt;em&gt;Foeniculum vulgare &lt;/em&gt;aerial parts and seeds.&lt;strong&gt; Methods&lt;/strong&gt;: The oils were extracted by hydro-distillation using a modified Clevenger-type apparatus and chemical composition was performed by Gas chromatography with flame-ionization detection (GC-FID) and Gas chromatography-mass spectrometry (GC–MS). Furthermore, an experimental trial was conducted, where 117 participants were divided into three groups, comprising a waiting list control group and two experimental groups treated with essential oils. The anxiety and depression indexes were evaluated by Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS). &lt;strong&gt;Results: &lt;/strong&gt;chemical analysis showed that trans- Anethole was the main component, both in the essential oil from aerial parts (35.5%) and seeds (79.2%). Anxiety and depression scores showed a decrease in posttest study phase in comparison with pretest in all experimental groups (p&amp;lt;0.05), except for depression scores in the group treated with essential oil from aerial parts (p&amp;gt;0.05). Small changes were found in the case of anxiety for group treated with essential oils from aerial parts (d = 0.41; Δ= 0.40) while moderate (d = 0.86; Δ = 0.85) and small (d = 0.38; Δ = 0.39) changes were found for anxiety and depression respectively, in the group treated with essential oil from seeds. &lt;strong&gt;Conclusion:&lt;/strong&gt; The essential oil from &lt;em&gt;Foeniculum vulgare&lt;/em&gt; seeds is more effective to relief anxiety than depression while the essential oil from&lt;em&gt; Foeniculum vulgare&lt;/em&gt; aerial parts only exhibit small changes for anxiety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Paul Alan Arkin Alvarado- García&lt;sup&gt;1,*&lt;/sup&gt;, Marilú Roxana Soto-Vasquez&lt;sup&gt;2&lt;/sup&gt;, Luis Enrique Rosales-Cerquin&lt;sup&gt;1&lt;/sup&gt;, Elda Maritza Rodrigo-Villanueva&lt;sup&gt;2&lt;/sup&gt;, Demetrio Rafael Jara-Aguilar&lt;sup&gt;2&lt;/sup&gt;, Lurdes Tuesta-Collantes&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina. Universidad César Vallejo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas. Universidad Nacional de Trujillo, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muthear N Dawood</style></author><author><style face="normal" font="default" size="100%">Shaymaa AH. Jassim</style></author><author><style face="normal" font="default" size="100%">Maab Azmi Fadel</style></author><author><style face="normal" font="default" size="100%">Imad A. Thanoon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Artificial Sweeteners Perturbed Liver Enzymes in Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Artificial Sweeteners</style></keyword><keyword><style  face="normal" font="default" size="100%">Bilirubin</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver Enzyme</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">553-557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In the recent time there has been an increased demand of low-fat or low calorie diet universally. In the mean while the availability of low calorie products has also increased like sugar free drinks, beverages, biscuits, jams and jellies. On contrary to this, some studies suggest that the prolong use of non-nutritive sweeteners alters the homeostasis of glucose and insulin. It results in fluctuation of glucose level in blood and increase in bodyweight. This study intends to evaluate the effect of non-nutritive sweeteners on the liver function test and record the alteration in the levels of ALP, AST and ALT. Seventy rats were divided into seven equal groups, controlled group received distilled water and the rest six were given NNS Sucrose, Stevia, Sucralose, Saccharine Aspartame and Acesulfame-k, respectively. On the evaluation of Alanine aminotransferase ALT, saccharine and aspartame markedly increased the level of ALT from 40U/L to 80 U/L. Both of these NNS have shown the most raised level of Alanine aminotransferase. This represents the stress on the liver associated with the use of NNS and suggests the use to be controlled in humans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">553</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muthear N Dawood&lt;sup&gt;1,*&lt;/sup&gt;, Shaymaa AH. Jassim&lt;sup&gt;2&lt;/sup&gt;, Maab Azmi Fadel&lt;sup&gt;3&lt;/sup&gt;, Imad A. Thanoon&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;College of Medicine, Ninevah University, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;College of Veterinary Medicine, University of Mosul, Mosul, IRAQ. 4College of Medicine, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Sofiatul Aini</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Dony Novaliendry</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Saddam Al Aziz</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Okta Suryani</style></author><author><style face="normal" font="default" size="100%">Putri Azhari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Agariadne Dwinggo Samala</style></author><author><style face="normal" font="default" size="100%">Mirella Fonda Maahury</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Compounds from Purslane (Portulaca oleracea L.) and Star Anise (Illicium verum Hook) as SARS-CoV-2 Antiviral Agent via Dual Inhibitor Mechanism: In Silico Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Illicium verum Hook</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Portulaca oleracea L.</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">352-357</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the COVID-19 pandemic that infects humans and attacks the body's immune system. The purpose of the study was to identify the potential of bioactive compounds in purslane (&lt;em&gt;Portulaca oleracea&lt;/em&gt; L.) and star anise (&lt;em&gt;Illicium verum&lt;/em&gt; Hook) via a dual inhibitor mechanism against SARS-CoV-2 proteases with an&lt;em&gt; in silico &lt;/em&gt;approach. The samples were obtained from PubChem and RSCB PDB. Antivirus probability prediction was performed on PASS Online. Virtual screening was performed with PyRx via molecular docking. Visualization was used by PyMol and Discovery Studio. Compounds with the best antiviral potential are indicated by the low binding affinity value to the target proteins, namely SARS-CoV-2 TMPRSS2 and PLpro. The results showed that purslane luteolin has the best antiviral potential. However, further studies are required to validate this computational prediction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">14</style></accession-num><section><style face="normal" font="default" size="100%">352</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Sofiatul Aini&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;2&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;2,4&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Dony Novaliendry&lt;sup&gt;8,9&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8,10&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;8,11&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;8,12&lt;/sup&gt;, Saddam Al Aziz&lt;sup&gt;8,13&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;8,12&lt;/sup&gt;, Okta Suryani&lt;sup&gt;8,11&lt;/sup&gt;, Putri Azhari&lt;sup&gt;8,14&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;8,12&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;8,15,&lt;/sup&gt; Agariadne Dwinggo Samala&lt;sup&gt;8,16&lt;/sup&gt;, Mirella Fonda Maahury&lt;sup&gt;17&lt;/sup&gt;, ANM Ansori&lt;sup&gt;18&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,11,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Study Program of Informatics, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department Mathematics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Agricultural Technology, Faculty of Agricultural Technology, Andalas University, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department Informatics and Computer Engineering Education, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Chemistry Department, Faculty Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zeina A Althanoon</style></author><author><style face="normal" font="default" size="100%">Imad AJ Thanoon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Effects of Amlodipine and Candesartan on Blood Pressure and Metabolic Profile in Non-Diabetic Hypertensive Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">141-147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The present study aimed to compare the effects of the angiotensin II receptor blocker candesartan and the calcium channel blocker amlodipine on blood pressure and metabolic profile in nondiabetic hypertensive patients. &lt;strong&gt;Methods: &lt;/strong&gt;The study involved non-diabetic patients with mild to moderate hypertension. They were randomly assigned to receive candesartan or amlodipine for 24 weeks, parameters were evaluated at baseline and after 12 weeks and 24 weeks for each patient group. &lt;strong&gt;Results:&lt;/strong&gt; Candesartan and amlodipine both reduced blood pressure and the HOMA-IR index significantly (P &amp;lt; 0.05, 24 weeks vs. baseline). Candesartan was more effective than amlodipine in lowering blood pressure and HOMA-IR, although the difference was not significant statistically.&lt;strong&gt; Conclusion:&lt;/strong&gt; Both candesartan and amlodipine are extremely effective at reducing blood pressure in moderate hypertension patients. Candesartan cilexetil has a major benefit in terms of tolerability, as it reduces the risk of developing metabolic dysregulation.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Amlodipine, Candesartan, Hypertension, Insulin resistance.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">141</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zeina A Althanoon&lt;sup&gt;1,*&lt;/sup&gt;, Imad AJ Thanoon&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;College of Medicine, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ichwan Baihaki</style></author><author><style face="normal" font="default" size="100%">Beti Ernawati Dewi</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Nunuk Hariani Soekamto</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Kuswati</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Kawther Ameen Muhammed Saeed Aledresi</style></author><author><style face="normal" font="default" size="100%">Nur Farhana Mohd Yusof</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Pavel Burkov</style></author><author><style face="normal" font="default" size="100%">Marina Derkho</style></author><author><style face="normal" font="default" size="100%">Pavel Scherbakov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Asmi Citra Malina AR Tasakka</style></author><author><style face="normal" font="default" size="100%">Tengku Siti Hajar Haryuna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dengue virus</style></keyword><keyword><style  face="normal" font="default" size="100%">NS1 antigen</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombocytopenia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">813-816</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p &amp;lt;0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">813</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ichwan Baihaki&lt;sup&gt;1&lt;/sup&gt;, Beti Ernawati Dewi&lt;sup&gt;2,3&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;4,5&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;7&lt;/sup&gt;, Nunuk Hariani Soekamto&lt;sup&gt;8&lt;/sup&gt;, ANM Ansori&lt;sup&gt;9&lt;/sup&gt;, Kuswati&lt;sup&gt;10&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;11&lt;/sup&gt;, Kawther Ameen Muhammed Saeed Aledresi&lt;sup&gt;12&lt;/sup&gt;, Nur Farhana Mohd Yusof&lt;sup&gt;13&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;14&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;15&lt;/sup&gt;,&lt;sup&gt;16,17&lt;/sup&gt;, Pavel Burkov&lt;sup&gt;18&lt;/sup&gt;, Marina Derkho&lt;sup&gt;18&lt;/sup&gt;, Pavel Scherbakov&lt;sup&gt;18&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;19,20,*&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;21&lt;/sup&gt;, Asmi Citra Malina AR Tasakka&lt;sup&gt;22&lt;/sup&gt;, Tengku Siti Hajar Haryuna&lt;sup&gt;23&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Indonesia-RSUPN Cipto Mangunkusumo, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Biology Education Study Program, Faculty of Teacher Training and Education, Jember University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Biochemistry Department, Hawler Medical University, Erbil, Arbil Governorate, Iraqi Kurdistan, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;20&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;21&lt;/sup&gt;Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;22&lt;/sup&gt;Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;23&lt;/sup&gt;Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Riskianto</style></author><author><style face="normal" font="default" size="100%">Andreanus Andaja Soemardji</style></author><author><style face="normal" font="default" size="100%">Marselina Irasonia Tan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Effects of Kirinyuh Herb (Austroeupatorium inulaefolium (Kunth) R. d. King &amp; H. Robinson) Extracts and Fractions on BSLT, MCF-7 Cells and T-47D Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BSLT</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Kirinyuh (Austroeupatorium inulaefolium (Kunth) R. D. King &amp; H. Robinson)</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword><keyword><style  face="normal" font="default" size="100%">T-47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">374-378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast Cancer is the second-highest prevalence of cancer disease in Indonesia, with the number of new cases and deaths continues to increase. &lt;em&gt;Kirinyuh &lt;/em&gt;or&lt;em&gt; Austroeupatorium&lt;/em&gt; inulaefolium (Kunth) R. D. King &amp;amp; H. Robinson is a shrub plant, which are widely grown in Indonesia. Traditionally, it is used for woundhealing and information about anticancer potential of &lt;em&gt;A. inulaefolium &lt;/em&gt;is still very limited. This study aims to assess the potential of cytotoxic activity of &lt;em&gt;A. inulaefolium &lt;/em&gt;on MCF-7 and T-47D breast cancer cells. Tests that carried out in this study were phytochemicals screening, Brine Shrimp Lethality Test (BSLT) and Cytotoxicity assay. The phytochemicals screening showed that EA (leaves extracts levels 1-3), EB (leaves extracts levels 4-6) and EC (stalk extracts) contained tannin, steroids/triterpenoids, flavonoids and phenols. The BSLT results showed that the EB has the smallest LC50 value of 12.86 μg/mL. MTT assay results showed the smallest IC50 value of the extract and the fraction on MCF-7 cells were EA 204.96 μg/ mL and FEA 205.43 μg/mL and T-47D cells were EB 217.03 μg/mL and FEA 192.36 μg/mL. The conclusion of toxicity and cytotoxicity of the herb (leaves and stalks) ethanol 96% extracts o&lt;em&gt;f A. inulaefolium &lt;/em&gt;had a very toxic effect on BSLT however had less potential cytotoxicity on MCF-7 cells and T-47D cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">374</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Riskianto&lt;sup&gt;1,*&lt;/sup&gt;, Andreanus Andaja Soemardji&lt;sup&gt;2&lt;/sup&gt;, Marselina Irasonia Tan&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacy, Faculty of Health Sciences, Universitas Pelita Harapan, Tangerang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology and Clinical Pharmacy, School of Pharmacy, Institut Teknologi Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Physiology, Animal Development and Biomedical Science, School of Life Sciences and Technology, Institut Teknologi Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Muhaimin</style></author><author><style face="normal" font="default" size="100%">Heriyanti</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination Antioxidant Activity of Coffea Arabica, Coffea Canephora, Coffea Liberica and Sunscreens Cream Formulation for Sun Protection Factor (SPF)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffee</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">SPF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">335-342</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coffee is a highly consumed and popular beverage consumed in many countries. Its ingredients have a powerful antioxidant capacity and have the potential as sunscreen to protect the skin. This study aimed to examine the antioxidant activity of Arabica, robusta and liberica coffee extracts and the SPF activity of the coffee extract cream formulation. Coffee were macerated with three types of solvents with polarity gradients. The fraction of each coffee was analyzed for antioxidant activity using DPPH and formulated into the cream. Furthermore, the cream was analyzed for its SPF activity. The results of this study indicated that the methanol fraction of Robusta and Arabica coffee has the best antioxidant activity with IC50 values of 8.98 (ppm) and 13.13, respectively. Meanwhile, Liberica coffee has the best antioxidant in the ethyl acetate fraction, IC&lt;sub&gt;50&lt;/sub&gt; = 10.90 (ppm). In addition, the best SPF values for Robusta, Liberica and Arabica coffees were found in F3 cream with the category of Very Good Protection; 36.087 ± 0.0005; 35.007 ± 0.0005; 36,867 ± 0.0005 respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">335</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief&lt;sup&gt;1,2&lt;/sup&gt;, Muhaimin&lt;sup&gt;3&lt;/sup&gt;, Heriyanti&lt;sup&gt;1,2&lt;/sup&gt;, Indra Lasmana Tarigan&lt;sup&gt;1,2&lt;/sup&gt;, Sutrisno&lt;sup&gt;1,2&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;The University Center of Excellence, E2- KOLIM, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjajaran, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Paulus Anthony Halim</style></author><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azoxymethane</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Fish oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega-3</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">259-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. &lt;strong&gt;Method:&lt;/strong&gt; The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows;&lt;strong&gt; Control Group:&lt;/strong&gt; mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. &lt;strong&gt;Result:&lt;/strong&gt; The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p&amp;lt;0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p&amp;lt;0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p&amp;lt;0.05) compared to the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">02</style></accession-num><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Paulus Anthony Halim&lt;sup&gt;3&lt;/sup&gt;, Wachid Putranto&lt;sup&gt;4,*&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Raja Yasmin Khalilah</style></author><author><style face="normal" font="default" size="100%">E Zuraidah</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Pomegranate Peel Ethanol Extract to TNF-α Expression of Mice Colonic Epithelial Cells Induced Using Dextran Sodium Sulfate (DSS)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Colonic epithelial cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranate peel ethanol extract</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">480-488</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The conventional drugs for inflammatory bowel disease (IBD) have many side effects that impact patient’s quality of life, leading to the emergence of alternative therapies such as pomegranate peel ethanol extract (PPE). This study aims to investigate the anti-inflammatory effect of PPE by observing TNF-α expression in mice induced chronic inflammation of the colon using dextran sodium sulfate (DSS). &lt;strong&gt;Methods:&lt;/strong&gt; 28 Swiss Webster mice samples were taken and divided into five groups, the control group (6 mice), the negative control group (5 mice), the group that was given DSS and aspirin (6 mice), the group was given DSS and a high dose of PPE (5 mice), and the group was given DSS and a low dose of PPE (6 mice). In mice, distal colonic tissue was taken and then stained immunohistochemically against TNF-α and observed with light microscopy at 400x magnification, and TNF-α expression was assessed using the H-Score. &lt;strong&gt;Results:&lt;/strong&gt; TNF-α expression was significantly lower in the group given a high dose of PPE than the negative control group (p &amp;lt;0.05), with mean rank scores of 3.00 and 8.00. There was no significant difference between the group given PPE with a high dose and aspirin (p&amp;gt; 0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; TNF-α expression in colonic epithelial cells of mice given DSS decreased upon treatment of a high dose of PPE, indicating a mechanism of decreasing inflammation. PPE also has the same effect as aspirin in reducing inflammation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">01</style></accession-num><section><style face="normal" font="default" size="100%">480</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-4, &lt;/sup&gt;Raja Yasmin Khalilah&lt;sup&gt;5&lt;/sup&gt;, E Zuraidah&lt;sup&gt;1,*&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;6&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine Universitas Indonesia, Salemba Raya Street no.6, 10430, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dody Taruna</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Reny I'tishom</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of High Intensity Swimming on Heat Shock Protein 70, Superoxide Dismutase and Malondialdehyde of Rattus norvegicus Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSP-70</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA.</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Strenuous physical activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">524-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aims to analyze relationship between physical activity with high intensity swimming by proving the difference in the mean levels of HSP-70, SOD levels and MDA levels in male white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who perform vigorous-intensity physical activity compared to male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;strong&gt; Method&lt;/strong&gt;: This research is a laboratory experimental research. This research is a True Experimental Research type that uses a Post Test Only Control Group Design research design. The experimental unit consisted of 28 white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;). The study was started by dividing the rats into 2 groups. Group 0 who did not receive heavy physical activity treatment and group 1 who received heavy intensity physical activity treatment 3 times a week for 4 weeks. &lt;strong&gt;Results: &lt;/strong&gt;The results of the Shapiro-Wilk test showed that the HSP-70 data were normally distributed (p&amp;lt;0.05). SOD and MDA data for all groups were normally distributed (p&amp;gt;0.05). The results of the Kruskal Wallis test showed that there was a significant difference in HSP-70 between groups (p &amp;gt; 0.05), the results of the Mann Whitney test showed that the HSP-70 of the K0 group was significantly different from the K1 group. The results of the analysis of variance with Brown-Forsythe showed that there was a significant difference in SOD between groups (p &amp;lt; 0.05). The results of the Games Howell test showed that the SOD of group K0 was significantly different from that of group K1. The results of the analysis of variance showed that there was a significant difference in MDA between groups (p &amp;lt; 0.05). The results of the LSD test showed that the MDA of the K0 group was significantly different from the K1 group. &lt;strong&gt;Conclusion&lt;/strong&gt;: There is a difference in the mean levels of HSP-70 in white male rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) whoperform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity. There is a difference in the mean SOD levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) which perform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not do strenuous physical activity. There is a difference in the mean MDA levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) after doing strenuous physical activity, higher than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">524</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dody Taruna&lt;sup&gt;1&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Lilik Herawati&lt;sup&gt;2&lt;/sup&gt;, Reny I'tishom&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, Indonesia. Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thi-Lien Nguyen</style></author><author><style face="normal" font="default" size="100%">Huong Ha Thi Thanh</style></author><author><style face="normal" font="default" size="100%">Kiet Ngo Tuan</style></author><author><style face="normal" font="default" size="100%">Doan Cao Son</style></author><author><style face="normal" font="default" size="100%">Thao Le Quang</style></author><author><style face="normal" font="default" size="100%">Hang Nguyen Thi</style></author><author><style face="normal" font="default" size="100%">Tien Vuong Duy</style></author><author><style face="normal" font="default" size="100%">Quyen Doan Thi Tam</style></author><author><style face="normal" font="default" size="100%">Huan Le Quang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antiviral Effects and Toxicity of Herbal Medicine Vipdervir Capsules</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">H5N1</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">681-689</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Antiviral vaccine is not effective, synthetic antiviral drugs are highly toxic, leading to increased interest in herbal medicines as promising antiviral drugs. Recently, Vipdervir has been developed from medicinal herbs with the aim to support and treat diseases caused by viruses such as H5N1 and SARSCoV- 2. In the present study, we assessed Vipdervir's antiviral activity against H5N1 and SARS-CoV-2. In addition, we also evaluated the acute toxicity and repeated dose toxicity of Vipdervir in mice and rabbits, respectively. &lt;strong&gt;Methods&lt;/strong&gt;: H5N1 inhibitory effect of Vipdervir was assessed using hemagglutination inhibition assay. Vipdervir's SARS-CoV-2 inhibitory effect was evaluated by Plaque Reduction Neutralization assay. Acute and repeated dose oral toxicities of Vipdervir were determined according to OECD 423 and OECD 407 guidelines, respectively. &lt;strong&gt;Results:&lt;/strong&gt; Data show that Vipdervir is effective against both H5N1 and SARSCoV- 2. At concentrations of 3 mg/mL and 5 mg/mL Vipdervir completely inhibits H5N1. At a concentration of 50 μg/mL Vipdervir showed an inhibitory effect on SARS-CoV-2. Acute toxicity data revealed that the LD50 of Vipdervir is greater than 35200 mg/kg, b.wt. in mice. Repeated toxicity data indicated that Vipdervir did not induce significant differences in body weight gain, hematology and clinical biochemistry in compared to the control group. The No Observed Adverse Effect Level of Vipdervir is greater than 613.8 mg/kg b.wt./day in rabbits. No delayed toxicity effects of Vipdervir were observed. &lt;strong&gt;Conclusion&lt;/strong&gt;: Vipdervir capsules were found to be antiviral effective and relatively safe in the tested doses and experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">27</style></accession-num><section><style face="normal" font="default" size="100%">681</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thi-Lien Nguyen&lt;sup&gt;1,*&lt;/sup&gt;, Huong Ha Thi Thanh&lt;sup&gt;2&lt;/sup&gt;, Kiet Ngo Tuan&lt;sup&gt;3&lt;/sup&gt;, Doan Cao Son&lt;sup&gt;1&lt;/sup&gt;, Thao Le Quang&lt;sup&gt;1&lt;/sup&gt;, Hang Nguyen Thi&lt;sup&gt;1&lt;/sup&gt;, Tien Vuong Duy&lt;sup&gt;1&lt;/sup&gt;, Quyen Doan Thi Tam&lt;sup&gt;4&lt;/sup&gt;, Huan Le Quang&lt;sup&gt;5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;National Institute of Drug Quality Control, 48-Hai Ba Trung st., Hoan Kiem dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;University of Science and Technology of Hanoi, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;High School for Gifted Students, Hanoi University of Science, 182- Luong The Vinh St., Thanh Xuan dist., Ha Noi city, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Institute of Biotechnology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet st., Cau Giay dist., Ha Noi city, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Narasimha Baba Brindavanam</style></author><author><style face="normal" font="default" size="100%">Gurinderjit Singh Goraya</style></author><author><style face="normal" font="default" size="100%">Santosh Pal Singh</style></author><author><style face="normal" font="default" size="100%">Amandeep Kumar</style></author><author><style face="normal" font="default" size="100%">Ankita Tiwari</style></author><author><style face="normal" font="default" size="100%">Badari Narayan Sarvepalli</style></author><author><style face="normal" font="default" size="100%">Pankaj Prasad Raturi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Genetic Diversity in Commiphora wightii (Arn.) Bhandari (Guggul): An Assessment of Populations in Conservation Sites of Kachchh Region (Gujarat) of India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gene Pool</style></keyword><keyword><style  face="normal" font="default" size="100%">Guggulu</style></keyword><keyword><style  face="normal" font="default" size="100%">In-situ conservation</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants Conservation Area</style></keyword><keyword><style  face="normal" font="default" size="100%">MPCA</style></keyword><keyword><style  face="normal" font="default" size="100%">UPGMA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">379-387</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Commiphora wightii&lt;/em&gt; (Arn.) Bhandari (Guggul) is native to semi-arid to arid zones. Its oleoresin gum is used for both medicinal and non-medicinal applications. Reportedly, the species faces high degree conservation threats. A network of Four Medicinal Plants Conservation Areas (MPCA) was carved out in Kachchh region- under financial support from National Medicinal Plants Board. The species also occurs in sanctuary and protected by default. It is considered important to assess genetic diversity of these conserved populations. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 38 accessions of Guggul leaves were collected from five study sites and the whole genomic DNA was extracted for each sample. Genetic study was carried out using ISSR technique. Scorable bands were obtained for 14 out of 40 primers tested. A total of 49 bands were obtained of which 20 were polymorphic in nature. UPGMA dendrograms were constructed for individual sites and also a collective dendrogram for all the study sites.&lt;strong&gt; Results:&lt;/strong&gt; All the 8 accessions of Tharawada MPCA were observed to share a high similarity coefficient. Among rest of three sites, genetic diversity was seen to be narrow. The accessions obtained from NSWS displayed good diversity. These accessions were also noted to be distant to the populations captured in the MPCA sites. &lt;strong&gt;Conclusions&lt;/strong&gt;: Established MPCA sites capture the available gene pool of &lt;em&gt;Commiphora wightii&lt;/em&gt; of Kachchh region. Since NSWS populations are distant to rest of the region, it is suggested to create another site for this purpose. It is desirable to assess the genetic diversity in rest of the MPCA sites.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><accession-num><style face="normal" font="default" size="100%">19</style></accession-num><section><style face="normal" font="default" size="100%">379</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Narasimha Baba Brindavanam&lt;sup&gt;1,*&lt;/sup&gt;, Gurinderjit Singh Goraya&lt;sup&gt;2&lt;/sup&gt;, Santosh Pal Singh&lt;sup&gt;3&lt;/sup&gt;, Amandeep Kumar&lt;sup&gt;4&lt;/sup&gt;, Ankita Tiwari&lt;sup&gt;4&lt;/sup&gt;, Badari Narayan Sarvepalli4, Pankaj Prasad Raturi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Amity School of Natural Resources and Sustainable Development, Amity University, Uttar Pradesh, Noida, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;IFS (Retired), (Formerly Principal Chief Conservator of Forests, Government of Himachal Pradesh and Dy. Director General, Indian Council of Forestry Research and Education, Dehradun), INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Director, Amity School of Natural Resources and Sustainable Development, Amity University, Uttar Pradesh, NOIDA (Formerly Principal Chief Conservator of Forests, Government of Assam and Dy. Director General, Indian Council of Forestry Research and Education, Dehradun), INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Bioresources Development Group, Dabur Research and Development Centre, Ghaziabad (UP), INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Priscilla Listiyani</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Md. Emdad Ullah</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Phytochemical Compounds Screening of Allium sativum Targeting the Mpro of SARS-CoV-2</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">604-609</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The global pandemic of coronavirus disease is still widely spread across the world causing catastrophic effect in both human life and global economy. By the end of year 2021, it has caused a total of 5.437.636 deaths across the world. Indonesia has rich plant biodiversity including medicinal plants that may be used for combating the virus. One of the commonly used medicinal plants comes from Allium species and it has been proved to have antiviral activity. Conducting an&lt;em&gt; in silico &lt;/em&gt;study, we screened bioactive compounds that came from &lt;em&gt;Allium sativum&lt;/em&gt; to fight against coronavirus through the inhibition of 3CL-Pro, one of the major protease that have an active role for viral replication. Molecular docking of compounds from &lt;em&gt;Allium sativum&lt;/em&gt; to 3CL-Pro resulting in the discovery of 5 compounds that have the best binding affinity to 3CL-Pro, which are squalene, 1,4-dihydro-2,3-benzoxathiin 3-oxide, 1,2,3-propanetriyl ester, trans-13-octadecenoic acid and methyl-11-hexadecenoate with binding affinity of -7, -6.5, -5.9, -5.7 and -5.6 kcal/mol, respectively. It is very likely that these compounds can be candidates for therapeutic agents and these candidates need to be studied further.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">18</style></accession-num><section><style face="normal" font="default" size="100%">604</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Priscilla Listiyani&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;1&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1,3&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;1,4&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;1&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5&lt;/sup&gt;, Md. Emdad Ullah&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,9,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Molecular Biology and Genetics, Genera si Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Mississippi State University, Mississippi State, UNITED STATES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Sofiatul Aini</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Elsa Yuniarti</style></author><author><style face="normal" font="default" size="100%">Saddam Al Aziz</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Amalia Putri Lubis</style></author><author><style face="normal" font="default" size="100%">Fajriah Azra</style></author><author><style face="normal" font="default" size="100%">Fadhilah Fitri</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Screening of Bioactive Compounds from Garcinia mangostana L. Against SARS-CoV-2 via Tetra Inhibitors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia mangostana L.</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">575-579</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The global COVID-19 pandemic caused by SARS-CoV-2 has been the resulted of massive human deaths since early 2020. The purpose of this study was to determine the potential of mangosteen (&lt;em&gt;Garcinia mangostana &lt;/em&gt;L.) as an inhibitor of RBD spike, helicase, Mpro, and RdRp activity of SARS-CoV-2 with an&lt;em&gt; in silico &lt;/em&gt;approach. The samples were obtained from PubChem and RCSB PDB. Analysis of the similarity of the drug was carried out with the Swiss ADME on the basis of Lipinski rule of five. Prediction of antivirus probabilities was carried out using PASS Online. Molecular screening was performed using PyRx through molecular docking. Discovery Studio was used for visualization. The bioactive compounds with the highest antiviral potential were indicated with the lowest binding affinity to the targeted proteins RBD spike, helicase, Mpro, and RdRp of SARS-CoV-2. The results indicated that mangiferin has the greatest potential as a potential antiviral. However, more research is required to validate the results of these computational predictions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">575</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Sofiatul Aini&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;2&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;2,4&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Elsa Yuniarti&lt;sup&gt;8,9&lt;/sup&gt;, Saddam Al Aziz&lt;sup&gt;8,10&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;8,11&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;8,11&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8,12&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;8,11&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;8,13&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;8,14&lt;/sup&gt;, Amalia Putri Lubis&lt;sup&gt;8,14&lt;/sup&gt;, Fajriah Azra&lt;sup&gt;8,14&lt;/sup&gt;, Fadhilah Fitri&lt;sup&gt;8,15&lt;/sup&gt;, ANM Ansori&lt;sup&gt;16&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;17,18,19&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,14,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department Mathematics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, RUSSIAN FEDERATION&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Sofiatul Aini</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Devni Prima Sari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Devi Pernamasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Muhardi</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Trisna Kumala Sari</style></author><author><style face="normal" font="default" size="100%">Titi Sriwahyuni</style></author><author><style face="normal" font="default" size="100%">Putri Azhari</style></author><author><style face="normal" font="default" size="100%">Mirella Fonda Maahury</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Screening of Bioactive Compounds from Syzygium cumini L. and Moringa oleifera L. Against SARS-CoV-2 via Tetra Inhibitors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral agent</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa Oleifera L</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">267-272</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The global pandemic of COVID-19 has caused disastrous consequences for both humans and the economy. The purpose of this study was to determine the potential of juwet (&lt;em&gt;Syzygium cumini&lt;/em&gt; L.) and moringa (&lt;em&gt;Moringa oleifera&lt;/em&gt; L.) as inhibitors of RBD spike, helicase, Mpro, and RdRp activity of SARS-CoV-2 with an &lt;em&gt;in-silico &lt;/em&gt;approach. Samples were obtained from PubChem and RSCB PDB databases. The drug similarity analysis was determined using Swiss ADME and the Lipinski rule of five. Prediction of antivirus probabilities is carried out with PASS Online. Molecular screening is performed by molecular docking using PyRx. Visualization was used using PyMol and Discovery Studio. The bioactive compounds with the best antiviral potential had the lowest affinity bonds to the target proteins against RBD spike, helicase, Mpro, and RdRp of SARS-CoV-2. Results show that ellagic acid from java plum and myricetin from moringa have the best potential as potential antivirals. However, more research is required to validate the results of these computational predictions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">03</style></accession-num><section><style face="normal" font="default" size="100%">267</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Sofiatul Aini&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;2&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;2,4&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5,&lt;/sup&gt; Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Devni Prima Sari&lt;sup&gt;8,9&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;8,10&lt;/sup&gt;, Devi Pernamasari&lt;sup&gt;8,11&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;8,10&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;8,10&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8,12&lt;/sup&gt;, Muhardi&lt;sup&gt;8,13&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;8,14&lt;/sup&gt;, Trisna Kumala Sari&lt;sup&gt;8,14&lt;/sup&gt;, Titi Sriwahyuni&lt;sup&gt;8,15&lt;/sup&gt;, Putri Azhari&lt;sup&gt;8,16&lt;/sup&gt;, Mirella Fonda Maahury&lt;sup&gt;17&lt;/sup&gt;, ANM Ansori&lt;sup&gt;18&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,14,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;STMIK Universitas Hang Tuah Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department Electronic Engineering Education, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Agricultural Technology, Faculty of Agricultural Technology, Andalas University, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Chemistry Department, Faculty Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Professor Nidom Foundation, Surabaya, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nala Mawaddani</style></author><author><style face="normal" font="default" size="100%">Ekris Sutiyanti</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Syamsurizal</style></author><author><style face="normal" font="default" size="100%">Bayu Ramadhani Fajri</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Amalia Putri Lubis</style></author><author><style face="normal" font="default" size="100%">Dony Novaliendry</style></author><author><style face="normal" font="default" size="100%">Dwi Hilda Putri</style></author><author><style face="normal" font="default" size="100%">Fadhilah Fitri</style></author><author><style face="normal" font="default" size="100%">Devni Prima Sari</style></author><author><style face="normal" font="default" size="100%">Alexander Patera Nugraha</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Study of Entry Inhibitor from Moringa oleifera Bioactive Compounds against SARS-CoV-2 Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Active site</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Mpro</style></keyword><keyword><style  face="normal" font="default" size="100%">RdRp</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">565-574</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study is to screen the content of bioactive compounds of &lt;em&gt;Moringa oleifera &lt;/em&gt;and to identify its potential as an antiviral against COVID 19 through an entry inhibitor mechanism using bioinformatics tools. The sample was obtained from PubChem database. Amino acis sequences were obtained from the NCBI. Protein modeling is made through the SWISSMODEL site. The target proteins for this study were SARS-CoV-2 M&lt;sup&gt;pro&lt;/sup&gt; and RdRp. The protein-inhibitory interaction of the drug from &lt;em&gt;M. oleifera&lt;/em&gt; bioactive compounds to SARS-CoV-2 was predicted by molecular docking with PyRx software. The result shows that&lt;em&gt; M. oleifera &lt;/em&gt;was a potential antiviral candidate for SARS-CoV-2 with an entry inhibitor mechanism through a compound, especially quercetin. The RFMS value of both interactions between M&lt;sup&gt;pro &lt;/sup&gt;and quercetion and RdRp with quercetin were not higher than 1.05. This result still needed further research to prove this prediction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">565</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nala Mawaddani&lt;sup&gt;1&lt;/sup&gt;, Ekris Sutiyanti&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;3&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;4&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;5&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;6&lt;/sup&gt;, Syamsurizal&lt;sup&gt;7,8&lt;/sup&gt;, Bayu Ramadhani Fajri&lt;sup&gt;7,9&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;7,10&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;7,10&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;7,10&lt;/sup&gt;, Amalia Putri Lubis&lt;sup&gt;7,11&lt;/sup&gt;, Dony Novaliendry&lt;sup&gt;7,12&lt;/sup&gt;, Dwi Hilda Putri&lt;sup&gt;7,8&lt;/sup&gt;, Fadhilah Fitri&lt;sup&gt;7&lt;/sup&gt;,&lt;sup&gt;13&lt;/sup&gt;, Devni Prima Sari&lt;sup&gt;7,14&lt;/sup&gt;, Alexander Patera Nugraha&lt;sup&gt;15&lt;/sup&gt;, ANM Ansori&lt;sup&gt;16&lt;/sup&gt; , Maksim Rebezov&lt;sup&gt;17,18,19&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;7,11,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Information Technology, Dapartement of Electronic, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Program Study Informatics, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Statistics, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, INDONESIA. 16Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, RUSSIAN FEDERATION&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Teguh Triyono</style></author><author><style face="normal" font="default" size="100%">Bambang Hendriawan Prasaja Jati</style></author><author><style face="normal" font="default" size="100%">Usi Sukorini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increased Risk of Tumor Necrosis Factor-Alpha Levels in Adult Patients with Malignancy Receiving Non-Leucodepleted Packed Red Cells Transfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malignancy</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-leucodepleted</style></keyword><keyword><style  face="normal" font="default" size="100%">PRC transfusion</style></keyword><keyword><style  face="normal" font="default" size="100%">Relative risk</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">778-781</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objectives:&lt;/strong&gt; Blood transfusion in patients with malignancy may evoke transfusion reactions. Leukocyte, as a major producer of cytokines, including Tumor Necrosis Factor-alpha (TNF-alpha), is considered to correlate to transfusion reactions. This study aims to determine the risk of increased TNFalpha in adult patients with malignancy who received non-leucodepleted (nLD) erythrocyte transfusion compared to those receiving leucodepleted (LD) Packed Red Cells (PRC) transfusion. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: This quasi-experimental study was conducted on adult patients with malignancy who required PRC transfusion and underwent outpatient treatment. The patients were divided without randomization into nLD and LD groups, and then their pre-transfusion TNF-alpha levels and the post-transfusion changes were examined.&lt;strong&gt; Results: &lt;/strong&gt;This study included thirty-one patients fulfilling the inclusion criteria. The TNFalpha levels in nLD and LD groups after transfusion increased significantly (p &amp;lt; 0.05), i.e., from 0.81 (0.2 - 4.2) pg/mL and 1.7 (0.15 - 6.3) pg/mL to 10.1 (1.4 - 28.9) and 5.9 (0.95 - 12.9) pg/mL. There was no significant difference in the pre-transfusion median TNF-alpha levels between the nLD and LD groups (p = 0.122). However, the post-transfusion median TNF-alpha levels of the nLD group were significantly higher (p = 0.024). It indicated that the increase in TNF-alpha levels is associated with nLD blood products transfused. The Relative Risk of the increased TNF-alpha levels in nLD-PRC transfusion was 2.01 (95% Confidence Interval: 1,153-3,502). &lt;strong&gt;Conclusion: &lt;/strong&gt;nLD-PRC transfusion poses a 2.01 times risk for increased TNF-alpha levels compared to LD-PRC transfusion.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">778</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Teguh Triyono&lt;sup&gt;1&lt;/sup&gt;, Bambang Hendriawan Prasaja Jati&lt;sup&gt;2&lt;/sup&gt;, Usi Sukorini&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Laboratory, Baa Regional Public Hospital, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Universitas Gadjah Mada, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Min Rahminiwati</style></author><author><style face="normal" font="default" size="100%">Trivadila</style></author><author><style face="normal" font="default" size="100%">Dyah Iswantini</style></author><author><style face="normal" font="default" size="100%">Hiroshi Takemori</style></author><author><style face="normal" font="default" size="100%">Mamoru Koketsu</style></author><author><style face="normal" font="default" size="100%">Rut Novalia Rahmawati Sianipar</style></author><author><style face="normal" font="default" size="100%">Suminar Setiati Achmadi</style></author><author><style face="normal" font="default" size="100%">Ahmad Sjahriza</style></author><author><style face="normal" font="default" size="100%">Betty Marita Soebrata</style></author><author><style face="normal" font="default" size="100%">Armi Wulanawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic obstructive pulmonary disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">432-444</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is a tropical country with mega-biodiversity. Several medicinal plants locally have been recognized for their anti-inflammatory properties and are traditionally used to help treat respiratory diseases. Chronic obstructive pulmonary disease (COPD) is one of the diseases known as the high cause of death globally, and one of the treatment efforts is by using anti-inflammatory drugs. In developing alternative remedies for COPD, this review summarizes the potential of Indonesian medicinal plants and their ingredients known to have an anti-inflammatory activity to develop alternative remedies for COPD. Primarily, we focus on the medicinal plants that have been scientifically proven to pose some biological activities, such as legetan warak (&lt;em&gt;Adenostemma lavenia&lt;/em&gt;), celery &lt;em&gt;(Apium graveolens&lt;/em&gt;),&lt;em&gt; pegagan&lt;/em&gt; (&lt;em&gt;Centella asiatica&lt;/em&gt;),&lt;em&gt; kenikir &lt;/em&gt;(&lt;em&gt;Cosmos caudatus&lt;/em&gt;), and &lt;em&gt;kersen (Muntingia calabura). &lt;/em&gt;This review is expected to provide more information about Indonesian medicinal plants and their potencies to be developed as COPD herbal medicine and, further, as a treatment to help patients suffering from coronavirus disease (COVID-19).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><accession-num><style face="normal" font="default" size="100%">26</style></accession-num><section><style face="normal" font="default" size="100%">432</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Min Rahminiwati&lt;sup&gt;1,4,*&lt;/sup&gt;, Trivadila&lt;sup&gt;2,4&lt;/sup&gt;, Dyah Iswantini&lt;sup&gt;2,4&lt;/sup&gt;,*, Hiroshi Takemori&lt;sup&gt;3&lt;/sup&gt;, Mamoru Koketsu&lt;sup&gt;3&lt;/sup&gt;, Rut Novalia Rahmawati Sianipar&lt;sup&gt;2&lt;/sup&gt;, Suminar Setiati Achmadi&lt;sup&gt;2,4&lt;/sup&gt;, Ahmad Sjahriza&lt;sup&gt;2&lt;/sup&gt;, Betty Marita Soebrata&lt;sup&gt;2&lt;/sup&gt;, Armi Wulanawati&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Tropical Biopharmaca Research Center, IPB University, Bogor 16128, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author><author><style face="normal" font="default" size="100%">Rumaida</style></author><author><style face="normal" font="default" size="100%">Indah Pramana Sari Aini</style></author><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation of a Flavone Apigenin and a Steroids Squalene from Peronema canescens Jack Leaves with Anti-Inflammatory Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Apigenin</style></keyword><keyword><style  face="normal" font="default" size="100%">P. canescens</style></keyword><keyword><style  face="normal" font="default" size="100%">Squalene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">744-752</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The leaves of the&lt;em&gt; P. canescens &lt;/em&gt;are ethnobotanically used by the community as a remedy for bruises and fever. This study aims to isolate both of ethanol and n-hexane fractions of&lt;em&gt; P. canescens &lt;/em&gt;Jack leaves. Isolate then characterized and determined their anti-inflammatory activity with male white mice. Anti- Inflammatory was determined by the volume of exudate and % inflammation inhibition. The isolates with good anti-inflammatory activity were characterized using UV-Vis and IR spectrophotometry. Our findings showed that the ethanolic (F1) and n-hexane (F2) fractions of&lt;em&gt; P&lt;/em&gt;. &lt;em&gt;canescens &lt;/em&gt;extract had a good anti-inflammatory activity with percent inhibition values of 58.12% and 56.59%, respectively. The characterization results showed that isolate F1 was a flavonoid group, Apigenin compound, while isolate F2 was a steroid group, Squalene compound.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">744</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Indra Lasmana Tarigan&lt;sup&gt;1&lt;/sup&gt;, Sutrisno&lt;sup&gt;1&lt;/sup&gt;, Rumaida&lt;sup&gt;2&lt;/sup&gt;, Indah Pramana Sari Aini&lt;sup&gt;2&lt;/sup&gt;, Madyawati Latief&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry, Faculty of Sciences and Technology, Universitas Jambi, Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry Student, Faculty of Sciences and Technology, Universitas Jambi, Jambi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fajar Herbowo Niantiarno</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author><author><style face="normal" font="default" size="100%">Myrna Adianti</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Abdul Hafid Bajamal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Kaempferia galanga L. Extract Administration Attenuate Aquaporin-4 Expression in Traumatic Brain Injury: An Experimental Study in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ayuverdic medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroinflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurotrauma</style></keyword><keyword><style  face="normal" font="default" size="100%">Post-traumatic cerebral edema</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">893-897</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Traumatic brain injury (TBI) is still a major health problem in the world. It might cause long-term disability that affect socio-economic life and become nation health burden. Post-traumatic cerebral edema might develop and commit to an unfavorable prognosis. Aquaporin 4 (AQP4) is water channel protein and a key regulator of water metabolism in the brain. Although the mechanism of AQP4 in the regulation of post-traumatic brain edema remains controversial, AQP4-lacking mice show better survival and decreased brain edema. Thus, novel strategies that suppress AQP4 become a potential field. We hypothesized that &lt;em&gt;Kaempferia galanga&lt;/em&gt; L. may suppress brain expression of AQP4 following TBI and possibly limit the development of cerebral edema due to its neuroinflammation properties. &lt;strong&gt;Method:&lt;/strong&gt; We conducted TBI to experimental rats, then given &lt;em&gt;Kaempferia galanga &lt;/em&gt;L. extract at a dose of 600 mg/kg BW and 1200 mg/kg BW. Evaluation intensity of AQP4 expression by immunohistochemistry was performed 24 and 48 hours later to see its therapeutic effect. &lt;strong&gt;Results:&lt;/strong&gt; Administration of &lt;em&gt;Kaempferia galanga &lt;/em&gt;L. extract at a dose of 1200 mg/kg BW showed weak expression of AQP4 in all samples, both 24 and 48 hours following traumatic brain injury treatment. &lt;strong&gt;Conclusions&lt;/strong&gt;: Intensity of AQP4 expression in rats’ brain was lower at 24 and 48 hours after TBI in rats receiving &lt;em&gt;Kaempferia galanga&lt;/em&gt; L. extract with dose 1200 mg/ kg BW compared to the other groups. Our result indicates that &lt;em&gt;Kaempferia galanga &lt;/em&gt;L. might affect the expression of brain AQP4 in a dose-dependent manner.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">893</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fajar Herbowo Niantiarno&lt;sup&gt;1&lt;/sup&gt;, Agus Turchan&lt;sup&gt;1,*&lt;/sup&gt;, Myrna Adianti&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Muhammad Arifin Parenrengi&lt;sup&gt;1&lt;/sup&gt;, Abdul Hafid Bajamal&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Traditional Medicine Study Program, Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Science and Preventive Medicine, Faculty of Medicine Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olivia Mahardani Adam</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mechanism of the Bioactive Sargassum cristaefolium in Inhibiting Inflammatory Mediators in a Nitroglycerin-Induced Migraine Model in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammatory mediator</style></keyword><keyword><style  face="normal" font="default" size="100%">Migraine</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitroglycerin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum cristaefolium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">388-396</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Migraine headaches are a form of sterile neurogenic inflammation. The sterile inflammatory process of the trigeminal nerve releases the vasoactive neuropeptide CGRP which stimulates the release of inflammatory mediators. In the incidence of migraine there is an increase in TNF-α and IL-10. &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract contains flavonoids, alkaloids, triterpenoids, steroids, and tannins, which has analgesic and anti-inflammatory function. &lt;strong&gt;Method: &lt;/strong&gt;&lt;em&gt;Sargassum cristaefolium &lt;/em&gt;was extracted using maceration method with 70% ethanol as solvent. Animal models were divided into 5 groups and given NTG induction 5 times with 1 day intervals, treated for 3 weeks. All data were analyzed using IBM SPSS version 26.0. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - CGRP levels β: -0.26, p: 0.17; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - CGRP expression β: -0.04, p: 0.85; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - TNF-α levels β: -0.63, p: 0.01; &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract - TNF-α expression β: -0.40, p: 0.04; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - IL-10 levels β: 0.77, p: 0.00; &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract - IL-10 expression β: 0.45, p: 0.01.&lt;strong&gt; Conclusions&lt;/strong&gt;: A significant path between the administration of &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract and a decrease in TNF-α and an increase in IL-10. But the effect of giving &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract on CGRP levels did not have a significant relationship.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olivia Mahardani Adam&lt;sup&gt;1,2&lt;/sup&gt;, Jusak Nugraha&lt;sup&gt;3,*&lt;/sup&gt;, Muhammad Hamdan&lt;sup&gt;4&lt;/sup&gt;, Agus Turchan&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syeftyan Muhammad Ali Hamami</style></author><author><style face="normal" font="default" size="100%">Michelle Fai</style></author><author><style face="normal" font="default" size="100%">Ahmad Fariduddin Aththar</style></author><author><style face="normal" font="default" size="100%">M Nizam Zulfi Zakaria</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Nikolai Maksimiuk</style></author><author><style face="normal" font="default" size="100%">Nataliya Kulmakova</style></author><author><style face="normal" font="default" size="100%">Evgeniya Latynina</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Oski Illiandri</style></author><author><style face="normal" font="default" size="100%">Khoirun Nisyak</style></author><author><style face="normal" font="default" size="100%">Ernarisa Fitri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Nano transdermal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum sp. .</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">789-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy’s side effects. Fucoidan is an anticancer bioactive compound derived from &lt;em&gt;Sargassum sp&lt;/em&gt;. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from &lt;em&gt;Sargassum sp.&lt;/em&gt; against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and &lt;em&gt;in silico&lt;/em&gt; study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from &lt;em&gt;Sargassum sp&lt;/em&gt;. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">789</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syeftyan Muhammad Ali Hamami&lt;sup&gt;1&lt;/sup&gt;, Michelle Fai&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fariduddin Aththar&lt;sup&gt;1&lt;/sup&gt;, M Nizam Zulfi Zakaria&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;3&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;4&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1,3,&lt;/sup&gt; Dora Dayu Rahma Turista&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8,9&lt;/sup&gt;, Nikolai Maksimiuk&lt;sup&gt;10&lt;/sup&gt;, Nataliya Kulmakova&lt;sup&gt;11&lt;/sup&gt;, Evgeniya Latynina&lt;sup&gt;11&lt;/sup&gt;, ANM Ansori&lt;sup&gt;12&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;13,14,*&lt;/sup&gt;, Riso Sari Mandeli &lt;sup&gt;15&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;16&lt;/sup&gt;, Oski Illiandri&lt;sup&gt;17&lt;/sup&gt;, Khoirun Nisyak&lt;sup&gt;18&lt;/sup&gt;, Ernarisa Fitri&lt;sup&gt;19&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Life Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Veterinary Medicine, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Biomedicine, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Department of Pharmacy, Faculty of Public Health, Universitas Anwar Medika, Sidoarjo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dian Samudra</style></author><author><style face="normal" font="default" size="100%">Widodo</style></author><author><style face="normal" font="default" size="100%">Nunuk Mardiana</style></author><author><style face="normal" font="default" size="100%">Artaria Tjempakasari</style></author><author><style face="normal" font="default" size="100%">Pranawa</style></author><author><style face="normal" font="default" size="100%">Aditiawardana</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephrotic Syndrome with Focal Segmental Glomerulosclerosis Histological Feature: A Case Report</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Focal segmental glomerulosclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephrotic syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Renal biopsy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">459-461</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Nephrotic syndrome is a clinical syndrome of heavy proteinuria and hypoalbuminemia or hypoproteinemia. Renal biopsy is fundamental to assess not only the type but also the degree of disease activity. The overall prognosis and response to treatment often depend on the severity of histological lesions and their reversibility.&lt;sup&gt;1,2&lt;/sup&gt; &lt;strong&gt;Case Presentation: &lt;/strong&gt;An eighteen years old man with nephrotic syndrome and planned for a kidney biopsy. This case showed a patient with swollen face (especially on the cheek). On Biopsy results showing the glomerulus proliferation of cells and mesangeal matrix, adhesions in (50%) glomerulus, focal sclerosis in some glomeruli, erythrocyte cells visible in the urinary space and thickening of the basement membrane in some glomeruli, partially atrophic tubules, visible erythrocytes in the tubular lumen. &lt;strong&gt;Conclusion:&lt;/strong&gt; An eighteen years old man with nephrotic syndrome with cushing syndrome and hypokalemia who had a renal biopsy. The histological feature from the renal biopsy was focal segmental glomerulosclerosis. The underlying cause of FSGS is still unclear. Assessing the diagnosis and etiology become important to direct the subsequent clinical approach and therapy&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><accession-num><style face="normal" font="default" size="100%">15</style></accession-num><section><style face="normal" font="default" size="100%">459</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dian Samudra&lt;sup&gt;1,*&lt;/sup&gt;, Widodo&lt;sup&gt;2&lt;/sup&gt;, Nunuk Mardiana&lt;sup&gt;2&lt;/sup&gt;, Artaria Tjempakasari&lt;sup&gt;2&lt;/sup&gt;, Pranawa&lt;sup&gt;2&lt;/sup&gt;, Aditiawardana&lt;sup&gt;2&lt;/sup&gt;, Anny Setijo Rahaju&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Internal Medicine Department, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Internal Medicine Department, Faculty of Medicine, Universitas Airlangga, General Teaching Hospital Dr. Soetomo, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Pathology Anatomy Department, Faculty of Medicine, Universitas Airlangga, General Teaching Hospital Dr. Soetomo, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Renan Dilton Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Luz Josefina Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre-Meza</style></author><author><style face="normal" font="default" size="100%">Mildred Hilda Cóndor- Privat</style></author><author><style face="normal" font="default" size="100%">Beatriz Lilian Galdos-Vadillo</style></author><author><style face="normal" font="default" size="100%">Jenny Mendoza-Vilcahuaman</style></author><author><style face="normal" font="default" size="100%">Rossibel Juana Muñoz-de-la-Torre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Geranium ruizii</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasuchaca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">315-321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii &lt;/em&gt;on alloxan-induced hyperglycemia in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Geranium ruizii&lt;/em&gt; was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (&lt;em&gt;Geranium ruizii &lt;/em&gt;extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;The hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii&lt;/em&gt;, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Renan Dilton Hañari-Quispe&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Josefa Bertha Pari- Olarte&lt;sup&gt;4&lt;/sup&gt;, Luz Josefina Chacaltana-Ramos&lt;sup&gt;4&lt;/sup&gt;, Eddie Loyola-Gonzales&lt;sup&gt;5&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;6&lt;/sup&gt;, Mildred Hilda Cóndor-Privat&lt;sup&gt;6&lt;/sup&gt;, Beatriz Lilian Galdos-Vadillo&lt;sup&gt;6&lt;/sup&gt;, Jenny Mendoza- Vilcahuaman&lt;sup&gt;7&lt;/sup&gt;, Rossibel Juana Muñozde-la-Torre&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman</style></author><author><style face="normal" font="default" size="100%">Fajar Prasetya</style></author><author><style face="normal" font="default" size="100%">Supriatno Salam</style></author><author><style face="normal" font="default" size="100%">Hifdzur Rashif Rijai</style></author><author><style face="normal" font="default" size="100%">Hadi Kuncoro</style></author><author><style face="normal" font="default" size="100%">Rolan Rusli</style></author><author><style face="normal" font="default" size="100%">Agung Rahmadani</style></author><author><style face="normal" font="default" size="100%">Hady Anshory Tamhid</style></author><author><style face="normal" font="default" size="100%">Kuswandi</style></author><author><style face="normal" font="default" size="100%">Dewanto Harjunowibowo</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile of Simplicia and Ethanolic Leaves Extract from Indonesian Piper betle var. nigra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Black betle</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper betle var. nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">610-618</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Piper betle&lt;/em&gt; var. nigra has potency as an herbal medication. Thus it can be used as a source of medicinal raw materials. &lt;em&gt;Piper betle&lt;/em&gt; var. nigra simplicia and extracts must be controlled to obtain unswerving quality and ensure their pharmacological effects by standardizing them through several specific and non-specific parameters. Specific parameters were analyzed organoleptically in the ethanol extract, namely having a thick consistency, brownish-green or blackish-green color, a mild peculiar odor, a bitter, cherish taste, and a slightly spicy flavor. The microscopic simplicia powder profile is as follows: the lower epidermis with idioblasts in oil cells contour and upper epidermis, sclerenchyma, covering hairs, and transport bundles ladder-type thickening, and idioblasts in oil cells contour. Extract content analysis of simplicia and black betle leaves ethanol extract showed water-soluble extract content of 2.77% and 12.45% and ethanolsoluble extract content of 1.38% and 19.1%. Secondary metabolites in the ethanol extract are flavonoids, polyphenols, tannins, saponins, alkaloids, and steroids. The non-specific parameters of the simplicia and extract are as follows; total ash content of 12.1% and 7.43%; acid insoluble ash content of 4.45% and 1.57%; drying shrinkage of 14.5% and 15.85%; total lead (Pb) contamination 47.5 ppm and 1.2 ppm; and the total cadmium (Cd) contamination &amp;lt;0.2 ppm. The total bacterial contamination in the extract was 4.3x105 colonies/g. The total yeast contamination was 8.3x105 colonies/g and volumetric mass density of the water-soluble extract of 0.96 g/mL and the volumetric mass density of the ethanol-soluble extract of 1.01 g/mL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">610</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman&lt;sup&gt;1,2,*&lt;/sup&gt;, Fajar Prasetya&lt;sup&gt;1,2&lt;/sup&gt;, Supriatno Salam&lt;sup&gt;1,2&lt;/sup&gt;, Hifdzur Rashif Rijai&lt;sup&gt;1,2&lt;/sup&gt;, Hadi Kuncoro&lt;sup&gt;1,2&lt;/sup&gt;, Rolan Rusli&lt;sup&gt;1,2&lt;/sup&gt;, Agung Rahmadani&lt;sup&gt;3&lt;/sup&gt;, Hady Anshory Tamhid&lt;sup&gt;4&lt;/sup&gt;, Dewanto Harjunowibowo&lt;sup&gt;5&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceuticals Research and Development Laboratory of Pharmaca Tropics, Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Chemistry Education, Faculty of Teaching and Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Jogjakarta 55584, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physics Education, Universitas Sebelas Maret, Surakarta, 57126, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erna Harfiani</style></author><author><style face="normal" font="default" size="100%">Yudhi Nugraha</style></author><author><style face="normal" font="default" size="100%">Citra Ayu Aprilia</style></author><author><style face="normal" font="default" size="100%">Feda Anisah Makkiyah</style></author><author><style face="normal" font="default" size="100%">Ratna Puspita</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Mirella Fonda Maahury</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Asmi Citra Malina A. R. Tasakka</style></author><author><style face="normal" font="default" size="100%">Alexander Patera Nugraha</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The phytochemical and pharmacological activity of extract Kirinyuh (Chromolaena odorata L.) leaves: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromolaena odorata</style></keyword><keyword><style  face="normal" font="default" size="100%">Kirinyuh</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">580-586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;C. odorata&lt;/em&gt; L. is considered to be a plant weed that is scattered in various climates. As a weed, this plant contains a variety of beneficial secondary metabolites. Several studies have shown the benefits of &lt;em&gt;C. odorata&lt;/em&gt; L. leaf extract. This study reviews the metabolite content and the pharmacological activities of &lt;em&gt;C. odorata&lt;/em&gt; L. leaf extract. A literature search was carried out to obtain various studies related to the use of this plant extract. Secondary metabolites identified in &lt;em&gt;C. odorata&lt;/em&gt; L. are alkaloids, flavonoids, tannins, saponins, and steroids. Several reports have also shown that even though it is considered a weed, &lt;em&gt;C. odorata &lt;/em&gt;L. leaf extract also provides many benefits due to its pharmacological activities. Various pharmacological activities include anti-inflammatory, anti-microbial, antioxidant, antidyslipidemia, hematologic agent, antidiabetic and anti-cataract, analgesic and antipyretic, wound healing, anti-malaria, mosquito larvicidal, antihypercholesterolemia, and antifungal.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">580</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erna Harfiani&lt;sup&gt;1&lt;/sup&gt;, Yudhi Nugraha&lt;sup&gt;2&lt;/sup&gt;, Citra Ayu Aprilia&lt;sup&gt;1&lt;/sup&gt;, Feda Anisah Makkiyah&lt;sup&gt;3&lt;/sup&gt;, Ratna Puspita&lt;sup&gt;4&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;5,6&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;5&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;7&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;8&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;9&lt;/sup&gt;, Mirella Fonda Maahury&lt;sup&gt;10&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;11&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;12&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;12&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;12&lt;/sup&gt;, Asmi Citra Malina A. R. Tasakka&lt;sup&gt;13&lt;/sup&gt;, Alexander Patera Nugraha&lt;sup&gt;14&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;15,16,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmacy, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Badan Riset dan Inovasi Nasional, Jakarta, INDONESIA. 3Department of Surgery, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yuna Islamiati</style></author><author><style face="normal" font="default" size="100%">Yani Suryani</style></author><author><style face="normal" font="default" size="100%">Ayuni Adawiyah</style></author><author><style face="normal" font="default" size="100%">Opik Taufiqurrohman</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Nunuk Hariani Soekamto</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author><author><style face="normal" font="default" size="100%">Kuswati</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Kawther Ameen Muhammed Saeed Aledresi</style></author><author><style face="normal" font="default" size="100%">Nur Farhana Mohd Yusof</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Shimanovskaya Yanina</style></author><author><style face="normal" font="default" size="100%">Belyakova Natalia</style></author><author><style face="normal" font="default" size="100%">Dmitriy Kulikov</style></author><author><style face="normal" font="default" size="100%">Gulnara Mullagulova</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential of Antivirus Compounds in Gletang (Tridax procumbens Linn.) in Inhibiting 3CLpro Receptor of SARS-CoV-2 Virus by In Silico</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3CLpro receptor</style></keyword><keyword><style  face="normal" font="default" size="100%">Antivirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Gletang</style></keyword><keyword><style  face="normal" font="default" size="100%">In-silico</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">796-805</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;SARS-CoV-2 virus has caused pandemic disease since the end of 2019. Virus transmission occurs through droplet and infects the host's respiratory tract rapidly. Viral propagation occurs through translation process of genome +ssRNA, then it being replicated forming some new body parts of virus and assemblied into virions that ready to infect. During the replication process, the translated viral genome in the form of polyprotein will be cut into smaller components by proteases, which one is 3CLpro. The presence of the 3CLpro receptor is used in drug development through &lt;em&gt;in-silico &lt;/em&gt;molecular docking process to minimize failures before laboratory test. The antivirus compounds that used to inhibit the 3CLpro receptor are from gletang plant (&lt;em&gt;Tridax procumbens&lt;/em&gt; Linn.). This study aim is to determine the value of binding affinity, the interaction between compounds and receptor, and the effect of drug components. The research was conducted by&lt;em&gt; in-silico&lt;/em&gt; through the molecular docking process of 3CLpro receptor and antivirus compounds of gletang (&lt;em&gt;Tridax procumbens&lt;/em&gt; Linn.), including betulinic acid, kaempferol and lignan. The results showed that the binding affinity of betulinic acid was -6.6 kcal/mol, kaempferol was -5.6 kcal/ mol and lignan was -5.4 kcal/mol. The interaction form of compounds and receptor was hydrogen bond, electrostatic, hydrophobic, and van der Waals. Compared to baicalein compound as a positive control with the value of binding affinity was -6.7 kcal/mol and its interaction with 3CLpro receptor, showed betulinic acid, kaempferol and lignan have smaller ability but they have the potential to inhibit the 3CLpro receptor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">796</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yuna Islamiati&lt;sup&gt;1&lt;/sup&gt;, Yani Suryani&lt;sup&gt;1&lt;/sup&gt;, Ayuni Adawiyah&lt;sup&gt;1&lt;/sup&gt;, Opik Taufiqurrohman&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2,3&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;4&lt;/sup&gt;, Nunuk Hariani Soekamto&lt;sup&gt;5&lt;/sup&gt;, Anny Setijo Rahaju&lt;sup&gt;6&lt;/sup&gt;, Kuswati&lt;sup&gt;7&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8&lt;/sup&gt;, Kawther Ameen Muhammed Saeed Aledresi&lt;sup&gt;9&lt;/sup&gt;, Nur Farhana Mohd Yusof&lt;sup&gt;10&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;11,12,13&lt;/sup&gt;, Shimanovskaya Yanina&lt;sup&gt;14&lt;/sup&gt;, Belyakova Natalia&lt;sup&gt;15&lt;/sup&gt;, Dmitriy Kulikov&lt;sup&gt;15&lt;/sup&gt;, Gulnara Mullagulova&lt;sup&gt;15&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;16,17,*&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;18&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Science, Hasanuddin University, INDONESIA&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Biology Education Study Program, Faculty of Teacher Training and Education, Jember University, INDONESIA&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;9&lt;/sup&gt;Biochemistry Department, Hawler Medical University, Erbil, Arbil Governorate, Iraqi Kurdistan, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;10&lt;/sup&gt;College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;12&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University, Moscow, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;14&lt;/sup&gt;Russian State Social University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;15&lt;/sup&gt;K.G. Razumovsky Moscow State University of Technologies and Management (the First Cossack University), Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;16&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;18&lt;/sup&gt;Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Heriyanti</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Data on the Antibacterial Activity of Coffea Arabica, Coffea Canephora and Coffea Liberica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffee</style></keyword><keyword><style  face="normal" font="default" size="100%">E. coli</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">413-424</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The continuous use of synthetic antibiotics will not only kill bacteria but also can accelerate the emergence of resistant pathogenic races. In addition, it can also cause the death of normal flora. Coffee extract is reported to have the potential as a naturally active and non-toxic antibacterial compound suitable for biomedical applications. Extraction using methanol was carried out on green coffee and which had been roasted for three types of Jambi coffee, namely Arabica, Robusta and Liberica coffee and continued with fractionation using hexane and ethyl acetate. The results of the analysis using FTIR showed that OH, C-H, C = C, C = O, C-O, C-N and N-H groups were detected. These functional groups are probably the functional groups that belong to caffeine, trigonelline, nicotinic acid and dehydrocafestol, which are believed to have bacteriostatic effects on some bacteria. The SEM-EDX analysis results of the three types of coffee showed that the dominant elements were O, K and Mg. Potassium and magnesium minerals bind with chlorogenic acid to form salt complexes of chlorogenic acid and magnesium chlorogenic acid complex. The antibacterial activity of the coffee extract and fraction was still low with the diameter of the inhibition zone was still low (0-10 mm). Furthermore, further characterization and tests are needed to confirm the antibiotic potency of the Arabica, Robusta and Liberica coffee ethanol extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">413</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief, Heriyanti, Indra Lasmana Tarigan, Sutrisno*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;The University Center of Excellence, E2- KOLIM, Universitas Jambi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Radebe Tlotlo</style></author><author><style face="normal" font="default" size="100%">Polo-Ma-Abiele Hildah Mfengwana</style></author><author><style face="normal" font="default" size="100%">Dedré Olivier</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review on Literature of the Plant Elephantorrhiza Elephantine on its Healing Properties and Recent Acquired Knowledge of its Medicinal Activities (2000-2020)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical content</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">715-721</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The current review article outlines current findings in literature from undertaken studies and review articles on the plant &lt;em&gt;Elephantorrhiza elephantine&lt;/em&gt; from the past 20 years to date. The information presented in this article will include the following aspects of the plant. The plant description and taxomony, ethnomedical uses, phytochemistry and pharmacology of &lt;em&gt;Elephantorrhiza elephantine. &lt;/em&gt;The article looks to discuss existing hurdles in research found on this plant and how to integrate any previous research with what is currently done in research on the plant. It aims on guiding the path of future research direction on the plant &lt;em&gt;Elephantorrhiza elephantine&lt;/em&gt;.&lt;strong&gt; Methods:&lt;/strong&gt; A total of 40 articles were selected and read through. The articles selected had included literature publications with the keywords such as; &lt;em&gt;Elephantorrhiza elephantine,&lt;/em&gt; plant description, taxonomic of the plant, ethno medicinal usages, phytochemicals, pharmacological properties and plant toxicity, which were published between the years 2000 – 2021. There were 32 articles relevant for this review article and 2 dissertation that were written between the criteria of years.&lt;strong&gt; Results: &lt;/strong&gt;The ethomedicinal uses of &lt;em&gt;Elephantorrhiza elephantine&lt;/em&gt; have been investigated by various authors on the anti-microbial activities, anti-inflammatory, anticancer and in ethnoveterinary medicine on how the plant provides relief to individuals with illnesses/disease through its traditional uses. These studies have been conducted on both animals and humans. The experiments performed used the crude extract derived from parts of the plant such as the roots and leaves. These plant parts have phytochemical compounds that are extracted using varying polar solvents. In the animal studies, acetone extracts of &lt;em&gt;E. elephantine&lt;/em&gt; roots demonstrated significant activity against a tick-borne disease in cattle livestock and parasite worms in goats. In humans, the dried leaf extracts of &lt;em&gt;E. elephantine&lt;/em&gt; was also subjected to various polar solvents and water, investigated for phytochemical content, antioxidant, anti-inflammatory, anti-diabetic and cytotoxic activities, using standard methods. It was reported that the ethanol extract yielded the highest phytochemical content.&lt;strong&gt; Conclusion:&lt;/strong&gt; The gap in knowledge has narrowed on medicinal plants effects of healing properties. This lead by extensive research carried out trying to understand the benefits of traditional medication and why majority of the population uses it as they primary healthcare choice. Investigating the mechanism of action of &lt;em&gt;E. elephantine&lt;/em&gt; on its antimicrobial, anti-diabetic, antimalarial, anti-inflammatory and wound healing could lead to an enhanced understanding on the medicinal properties of the plant extracts and a commercialisation of a product in future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><accession-num><style face="normal" font="default" size="100%">31</style></accession-num><section><style face="normal" font="default" size="100%">715</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Radebe Tlotlo&lt;sup&gt;1,*&lt;/sup&gt;, Polo-Ma-Abiele Hildah Mfengwana&lt;sup&gt;2&lt;/sup&gt;, Dedré Olivier&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, P/Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, P/Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, P/Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anita Kumari Tharu</style></author><author><style face="normal" font="default" size="100%">Mukti Ram Paudel</style></author><author><style face="normal" font="default" size="100%">Ananda Prakash Joshi</style></author><author><style face="normal" font="default" size="100%">Laxman Bhandari</style></author><author><style face="normal" font="default" size="100%">Hari Prasad Aryal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening of Secondary Metabolites and Antioxidant Activity of Wild Edible Termite Mushroom</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">phenolic</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Termite mushroom</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">301-307</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Wild edible mushrooms produce a variety of bioactive compounds that are known to have antioxidant properties. Natural antioxidants can protect against oxidative induced free radicals without any side effects. Thus, they are consumed by people for food and nutraceutical values. The purpose of this study was to evaluate the phytochemicals and antioxidant activity of three wild edible termite mushrooms (&lt;em&gt;Termitomyces albuminosus, T. eurhizus and T. robustus&lt;/em&gt;). Different phytochemicals were screened in the 50% ethanol, methanol and water extracts of three termite mushrooms. Total phenolic and flavonoid contents were determined by Folin-Ciocalteau and aluminium chloride method respectively. The antioxidant activity of three termite mushrooms was evaluated by DPPH assay. Qualitative screening of phytochemicals has revealed that alkaloid, steroid, fatty acid, flavonoid, saponin, tannin, carbohydrate and protein are found in the 50% ethanol, methanol and water extracts of three species of termite mushroom. A high amount of total phenolic and flavonoid content was found in the 50% ethanol extract of&lt;em&gt; T. albuminosus, T. eurhizus and T. robustus&lt;/em&gt; (TPC: 50.28, 54.56 and 57.63 mg GAE/g extract; TFC: 16.30, 18.43 and 18.80 mg QE/g extract respectively). Due to high phenolic and flavonoid content, 50% ethanol extract of three termite mushrooms has shown high antioxidant activity (i.e., lowest IC50: 710.00 - 714.05 μg/ml). These termite mushrooms have antioxidant properties due to the presence of bioactive secondary metabolites that can potentially be used as a source of natural antioxidants in the form of food and nutraceutical.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">301</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anita Kumari Tharu&lt;sup&gt;1&lt;/sup&gt;, Mukti Ram Paudel&lt;sup&gt;1&lt;/sup&gt;, Ananda Prakash Joshi&lt;sup&gt;2&lt;/sup&gt;, Laxman Bhandari&lt;sup&gt;3&lt;/sup&gt;, Hari Prasad Aryal&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Central Department of Botany, Tribhuvan University, Kathmandu, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Ayshwarya Multiple Campus, Dhangadhi, KAILALI.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;National Medicines Laboratory, Department of Drug Administration, Ministry of Health and Population, Kathmandu, NEPAL&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">AF Dibha</style></author><author><style face="normal" font="default" size="100%">S Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">VD Kharisma</style></author><author><style face="normal" font="default" size="100%">MH Widyananda</style></author><author><style face="normal" font="default" size="100%">AA Parikesit</style></author><author><style face="normal" font="default" size="100%">MT Sibero</style></author><author><style face="normal" font="default" size="100%">RT Probojati</style></author><author><style face="normal" font="default" size="100%">AAA Murtadlo</style></author><author><style face="normal" font="default" size="100%">JP Trinugroho</style></author><author><style face="normal" font="default" size="100%">TH Sucipto</style></author><author><style face="normal" font="default" size="100%">DDR Turista</style></author><author><style face="normal" font="default" size="100%">I Rosadi</style></author><author><style face="normal" font="default" size="100%">ME Ullah</style></author><author><style face="normal" font="default" size="100%">V Jakhmola</style></author><author><style face="normal" font="default" size="100%">R Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Utilization of Secondary Metabolites in Algae Kappaphycus alvarezii as a Breast Cancer Drug with a Computational Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">K. alvarezii</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Docking.</style></keyword><keyword><style  face="normal" font="default" size="100%">NF kB protein kinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">536-543</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is one of the worst diseases that affect female people. Long-term treatment with therapy or surgery has a detrimental impact on the patient. The algae &lt;em&gt;Kappaphycus alvarezii&lt;/em&gt; has gotten a lot of interest as a breast cancer medication because it contains chemicals that are expected to be anti-cancer. The objectives of this paper were to see how secondary metabolites in algae interact with the Nuclear Factor- kappaB protein kinase in breast cancer. The ligands and proteins were obtained from the PubChem and PDB websites, respectively. Swiss ADME was then used to assess the Pharmacokinetics and Drug likeness Properties. The last stage involved using molecular docking with PyRx and molecular dynamics to identify the interaction and visualization between the ligand and the target protein. The findings of the test revealed that the maraniol chemical had a superior binding capacity with NF kB protein kinase because it has a chromone group that controls transport efficiently in preventing breast cancer proliferation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">08</style></accession-num><section><style face="normal" font="default" size="100%">536</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;AF Dibha&lt;sup&gt;1&lt;/sup&gt;, S Wahyuningsih&lt;sup&gt;2&lt;/sup&gt;, ANM Ansori&lt;sup&gt;3&lt;/sup&gt;, VD Kharisma&lt;sup&gt;4&lt;/sup&gt;, MH Widyananda&lt;sup&gt;4,5&lt;/sup&gt;, AA Parikesit&lt;sup&gt;6&lt;/sup&gt;, MT Sibero&lt;sup&gt;7&lt;/sup&gt;, RT Probojati&lt;sup&gt;4,8&lt;/sup&gt;, AAA Murtadlo&lt;sup&gt;4&lt;/sup&gt;, JP Trinugroho&lt;sup&gt;9&lt;/sup&gt;, TH Sucipto&lt;sup&gt;10&lt;/sup&gt;, DDR Turista&lt;sup&gt;11&lt;/sup&gt;, I Rosadi&lt;sup&gt;12&lt;/sup&gt;, ME Ullah&lt;sup&gt;13,&lt;/sup&gt; V Jakhmola&lt;sup&gt;14&lt;/sup&gt;, R Zainul&lt;sup&gt;15,16,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biology, Gadjah Mada University, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Life Sciences, Imperial College London, South Kensington Campus, London, UNITED KINGDOM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Chemistry, Mississippi State University, Mississippi State, UNITED STATES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hlapisi N</style></author><author><style face="normal" font="default" size="100%">Maliehe TS</style></author><author><style face="normal" font="default" size="100%">Oluwafemi OS</style></author><author><style face="normal" font="default" size="100%">Songca SP</style></author><author><style face="normal" font="default" size="100%">Linganiso L</style></author><author><style face="normal" font="default" size="100%">Motaung TE</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activities of Cationic Porphyrins and Porphyrin Encapsulated Gold Nanorods on Bacterial Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Porphyrin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1086-1096</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Bacterial infections form part of the major causes of mortality and morbidity around the world more especially in developing and under-developed countries. Cationic porphyrins have been reported to display better efficacy in antimicrobial photodynamic therapy activity. The purpose of this study was to synthesise the cationic porphyrins; (TAP) and (TPyP) and evaluate their pharmacokinetics and metabolic interactions with the DNA gyrase subunit A. The antibacterial activity of the nano-conjugates was evaluated against &lt;em&gt;Staphylococcus aureus &lt;/em&gt;(ATCC 25925), &lt;em&gt;Enterococcus faecalis &lt;/em&gt;(ATCC 29212) and &lt;em&gt;Klebsiella pneumoniae&lt;/em&gt; (ATCC 4352) using the micro-dilution assay without light. AutoDock Vina was used to assess the molecular interactions between ligands and the DNA gyrase subunit A. The SwissADME online tool was used to assess the pharmacokinetic properties of the nano-conjugates, while the ADMETlab online tool was used to assess the ability to inhibit the hERG gene, human hepatotoxicity and mutagenicity. The test nano-conjugates showed broad-spectrum antibacterial activity against all tested bacterial strains with the MIC values in a range of 0.42 ± 0.1 to2.6 ± 0.7 mg/ml. The nano-conjugates revealed good molecular interaction with DNA gyrase subunit A with their binding free energy in the range of -8.3 to -8.7 kcal/ mol. They are predicted to be P-glycoprotein (P-gp) substrates, able to penetrate the blood-brain barrier and non-inhibitors of cytochrome P450 (CYP) isomers (CYP 2C19, CYP 2C9 and CYP 2D6). Both nanoconjugates have the potential to cause cardiotoxic and mutagenic effects but not hepatotoxic effects. The results show that the synthesized compounds have the potential as anti-bacterial PDT agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1086</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hlapisi N&lt;sup&gt;1,&lt;/sup&gt;*, Maliehe TS&lt;sup&gt;2&lt;/sup&gt;, Oluwafemi OS&lt;sup&gt;2&lt;/sup&gt;, Songca SP&lt;sup&gt;3&lt;/sup&gt;, Linganiso L&lt;sup&gt;1&lt;/sup&gt;, Motaung TE&lt;sup&gt;4,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, University of Zululand, Private Bag X 1001, KwaDlangezwa 3886, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, P.O. Box 17011, Doornfontein 2028, South Africa, Centre for Nanomaterials Science Research, University of Johannesburg, Johannesburg, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, University of KwaZulu Natal, Private Bag X 54001, Durban 4000, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, School of Science in the College of Science Engineering and Technology, University of South Africa, Preller Street, Muckleneuk Ridge, City of Tshwane, P.O. Box 392, UNISA 0003.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Sefako Makgatho Health Science University, P.O. Box 94, Medunsa, 0204, South Africa&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Waleed Khaled Al ani</style></author><author><style face="normal" font="default" size="100%">Ali Abdallah Alqudah</style></author><author><style face="normal" font="default" size="100%">Khaled. A. Tarawneh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial and Antioxidant Activities of Ethanol Extracts of Some Plants Selected from South Jordan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Peganum harmala</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">528-534</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Three Jordanian medicinal plants; Peganum harmala (&lt;em&gt;P. harmala&lt;/em&gt;), &lt;em&gt;Geropogon hybridus &lt;/em&gt;(&lt;em&gt;G. hybridus&lt;/em&gt;), and Salvia officinalis (&lt;em&gt;S. officinalis&lt;/em&gt;) were selected from Al-karak region in order to investigate their antibacterial and antioxidant activities. The crude extract yield of all used plants were varied from 10.6% in Salvia officinalis and 15.6% in&lt;em&gt; P. harmala&lt;/em&gt;, to 18 % in&lt;em&gt; G. hybridus&lt;/em&gt;. The antibacterial activity of these plants was carried out on four bacterial strain (&lt;em&gt;S. aureus, E.coli, E. aerogenes and B. subtilis&lt;/em&gt;). These plant ethanol extracts have effects on the gram positive strains and gram negative bacteria except&lt;em&gt; S. officinalis&lt;/em&gt; did not show activity against E. Coli. The minimal inhibition concentration (MIC) of &lt;em&gt;P. harmala&lt;/em&gt; &lt;em&gt;S. officinalis&lt;/em&gt; and &lt;em&gt;G. hybridus&lt;/em&gt; (MIC) ranged from 125 μg/ml to 500 μg/ml. The ethanol crude extract of &lt;em&gt;G. hybridus &lt;/em&gt;gave 10 fractions using TLC method, fraction 1,3 and 10 exhibited antibacterial activity against all bacterial strains. Their total phenolic contents were evaluated; the highest total phenol content was observed in &lt;em&gt;G. hybridus&lt;/em&gt; with 410 mgGAE/g plant extract followed by &lt;em&gt;P. harmal&lt;/em&gt;a and &lt;em&gt;S. officinalis &lt;/em&gt;with 305 and 203.7 mg/g plant extract, respectively. The antioxidant activity was estimated by using DPPH method. The highest antioxidant activity was obtained with &lt;em&gt;G. hybridus&lt;/em&gt; extract and found to be 0.89 mg Trolox/g plant extract. The lowest antioxidant activity was obtained with &lt;em&gt;S. officinalis&lt;/em&gt; which was 0.53 mg Trolox/g plant extract. The lowest IC&lt;sub&gt;50&lt;/sub&gt; (highest antioxidant activity) was observed in &lt;em&gt;G. hybridus &lt;/em&gt;with 0.83 mg/ml. Intermediate effect observed in &lt;em&gt;P. harmala&lt;/em&gt; with IC&lt;sub&gt;50&lt;/sub&gt; 1.1 mg/ml. The lowest antioxidant activity was obtained in &lt;em&gt;S. officinalis &lt;/em&gt;with IC&lt;sub&gt;50&lt;/sub&gt; 1.38 mg/ml.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">528</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Waleed Khaled Al ani&lt;sup&gt;1&lt;/sup&gt;, Ali Abdallah Alqudah&lt;sup&gt;2,&lt;/sup&gt;*, Khaled. A. Tarawneh&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science, Mu`tah University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of applied Biology, Faculty of Science, Tafila Technical University, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Charlotte Mungho Tata</style></author><author><style face="normal" font="default" size="100%">Constance Rufaro Sewani-Rusike</style></author><author><style face="normal" font="default" size="100%">Olukayode Aremu</style></author><author><style face="normal" font="default" size="100%">Opeoluwa Oyehan Oyedeji</style></author><author><style face="normal" font="default" size="100%">Benedicta Ngwenchi Nkeh-Chungag</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antihypertensive Effects of Osteospermum Imbricatum in Two Hypertensive Rat Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">High blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Nω-Nitro-L-arginine methyl ester</style></keyword><keyword><style  face="normal" font="default" size="100%">Spontaneously hypertensive rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">744-751</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Osteospermum imbricatum &lt;/em&gt;is used traditionally in Eastern Cape, South Africa for the management of hypertension, chest and stomach complaints. This study was aimed at investigating the antioxidant and antihypertensive effects of this plant. &lt;strong&gt;Methods: &lt;/strong&gt;Antioxidant capacity was determined by radical scavenging assays and ferric reducing antioxidant power. Antihypertensive effects after once off treatment with the leaf/root extracts (500 mg/kg) were evaluated in spontaneously hypertensive rats (SHR). The effect of the extracts on established hypertension was determined in Wistar rats treated with Nω-Nitro-L-arginine methyl ester (L-NAME) (40 mg/kg/day) for 4 weeks followed by co-treatment with L-NAME and extracts (200 mg/kg and 400 mg/kg) or amlodipine (5 mg/kg) or normal saline for 4 more weeks. &lt;strong&gt;Results:&lt;/strong&gt; The concentration at which there was 50 % inhibition (IC&lt;sub&gt;50&lt;/sub&gt;) of DPPH radical by the extracts was lower for the leaf extract (0.79 mg/mL) compared to the root extract (1.15 mg/mL). The leaf extract significantly (p&amp;lt;0.01) decreased systolic and diastolic blood pressures in both rat models. &lt;strong&gt;Conclusion: &lt;/strong&gt;The extracts of &lt;em&gt;Omsteospermum imbricatu&lt;/em&gt; have moderate antioxidants and antihypertensive properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">744</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Charlotte Mungho Tata&lt;sup&gt;1&lt;/sup&gt;, Constance Rufaro Sewani- Rusike&lt;sup&gt;1&lt;/sup&gt;, Olukayode Aremu&lt;sup&gt;1&lt;/sup&gt;, Opeoluwa Oyehan Oyedeji&lt;sup&gt;2&lt;/sup&gt;, Benedicta Ngwenchi Nkeh- Chungag&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Science and Agriculture, University of Fort Hare, PBX1314 Alice, 5700 Eastern Cape Province, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological and Environmental Sciences, Faculty of Natural Sciences, Walter Sisulu University, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marilú Roxana Soto-Vásquez</style></author><author><style face="normal" font="default" size="100%">Madeleine Vanessa Horna -Pinedo</style></author><author><style face="normal" font="default" size="100%">Luciana R Tallini</style></author><author><style face="normal" font="default" size="100%">Jaume Bastida</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and In Vitro Antiplasmodial Activity of the Total Alkaloids of the Bulbs of Two Amaryllidaceae Species from Northern Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Clinanthus incarnatus</style></keyword><keyword><style  face="normal" font="default" size="100%">Clinanthus ruber</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium falciparum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1046-1052</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The amaryllidaceae family is characterized by presenting alkaloids with powerful pharmacological activities, including antiprotozoal activity. The aim of the present work was to determine the chemical composition and evaluate the in vitro antiplasmodial activity of the total alkaloids of the bulbs of two amaryllidaceae species from northern Perú. &lt;strong&gt;Methods: &lt;/strong&gt;The total alkaloids were extracted from the bulbs using an acid-base extraction. The chemical composition of the total alkaloids was determined by GC-MS, using galantamine as a reference standard. It was investigated the in vitro antiplasmodial activity against &lt;em&gt;Plasmodium falciparum&lt;/em&gt; FCR-3 strain (chloroquine-resistant). &lt;strong&gt;Results:&lt;/strong&gt; 8 alkaloids were identified in the bulbs of &lt;em&gt;Clinanthus incarnatus&lt;/em&gt;: lycorine, galanthamine, galanthine, vittatine/crinine, hippamine, 3-O-acetylpowelline, 11,12-dehydroanhydrolycorine, 1-O-acetyllycorine with values of 19.73; 14.99; 10.36; 10.22; 10.16; 10.14; 10.04; 9.85 μg GAL/100 mg of total alkaloid (TA) respectively and 6 alkaloids in the bulbs of &lt;em&gt;Clinanthus ruber:&lt;/em&gt; lycorine, anhydrolycorine, 11,12-dehydroanhydrolycorine, 2,4-didehydro-2-dehydroxylycorine, 8-0-dimethylmaritidine, hippamine, with values of 70.2; 18; 4.15; 3.45; 6.8 and 0.1 μg GAL/100 mg TA respectively. The total alkaloids of the species of C. incarnatus and &lt;em&gt;C. ruber&lt;/em&gt; at concentrations of 1.0; 2.5; 5.0; 10.0; 25.0 and 50.0 μg/ml presented inhibition percentages of 23.5 ± 0.46% to 94 ± 0.56% against &lt;em&gt;P. falciparum&lt;/em&gt; with (p &amp;lt;0.05). They also presented IC&lt;sub&gt;50 &lt;/sub&gt;0.375 μg/ml (C. incarnatus) and IC&lt;sub&gt;50&lt;/sub&gt; 0.241 μg / ml (&lt;em&gt;C. ruber&lt;/em&gt;). &lt;strong&gt;Conclusion:&lt;/strong&gt; The main component of total alkaloids of the bulbs of two species was lycorine, in adittion, these species showed in vitro antiplasmoidal activity against Plasmodium falciparum FCR-3 strain at the doses tested.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marilú Roxana Soto-Vásquez&lt;sup&gt;1,&lt;/sup&gt;*, Madeleine Vanessa Horna -Pinedo&lt;sup&gt;1&lt;/sup&gt;, Luciana R. Tallini&lt;sup&gt;2&lt;/sup&gt;, Jaume Bastida&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre RS 90610- 000, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia, Universitat de Barcelona, Av. Joan&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Akanksha Mittal</style></author><author><style face="normal" font="default" size="100%">Sunil Tejaswi</style></author><author><style face="normal" font="default" size="100%">Mruthunjaya K</style></author><author><style face="normal" font="default" size="100%">Suneeth Shetty</style></author><author><style face="normal" font="default" size="100%">Ambikathanaya UK</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Antibacterial Activity of Calcium Hydroxide, Azadirachta Indica (Neem), Ocimum Tenuiflorum (Tulsi) and Punica Granatum (Pomegranate) Gels as Intracanal Medicaments Against Enterococcus Faecalis: An in-vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Calcium hydroxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Enterococcus faecalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">Intracanal medicaments</style></keyword><keyword><style  face="normal" font="default" size="100%">Microbial sensitivity tests</style></keyword><keyword><style  face="normal" font="default" size="100%">Root canal therapy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">988-994</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;This study aimed to evaluate the antibacterial activity of Calcium hydroxide, Azadirachta indica (Neem), Ocimum tenuiflorum (Tulsi) and Punica granatum (Pomegranate) gels as intracanal medicaments against &lt;em&gt;Enterococcus faecalis&lt;/em&gt;. &lt;strong&gt;Methodology:&lt;/strong&gt; Crude extracts of Pomegranate peel, Neem leaves and Tulsi leaves were used to determine MIC following which gels of 5% neem, 10% tulsi and 10% pomegranate were prepared. Forty-eight single rooted human premolars were procured and inoculated with E.faecalis for 7 days. Specimens were then randomly distributed into 4 groups.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Group I- Calcium hydroxide&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Group II- 5% A. indica (Neem) gel&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Group III- 10% O. tenuiflorum (Tulsi) gel&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Group IV-10%&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;P. granatum (Pomegranate) gel The experimental gels were then introduced into the samples and were sealed at both ends. The antimicrobial activity of medicaments was assessed by measuring CFU/ml at the end of 1, 3 and 5 days. &lt;strong&gt;Results:&lt;/strong&gt; Calcium hydroxide showed the maximum antibacterial activity (5.3X10&lt;sup&gt;4 &lt;/sup&gt;CFU/ml) followed by Pomegranate gel (5.4 X10&lt;sup&gt;4&lt;/sup&gt; CFU/ml) with no statistically significant difference between them. Similarly, no statistically significant difference was observed between the mean CFU/ml values of the neem (10.2 X10&lt;sup&gt;4 &lt;/sup&gt;CFU/ml) and tulsi gel (10.2 X10&lt;sup&gt;4&lt;/sup&gt; CFU/ml). However, pomegranate gel showed statistically significant antibacterial activity when compared to Neem and Tulsi. (Table 1, Table 2, Table 3, table 4) (Figure 1). &lt;strong&gt;Conclusion:&lt;/strong&gt; Calcium hydroxide showed the best antibacterial activity against E.faecalis. Among herbal gels, pomegranate showed the maximum antibacterial activity, however, further &lt;em&gt;in-vivo&lt;/em&gt; research is required for it to be used as a sole intracanal medicament clinically.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">988</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Akanksha Mittal, Sunil Tejaswi*, Mruthunjaya K, Suneeth Shetty, Ambikathanaya UK&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;JSS Dental College and Hospital, Mysuru, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sasithorn Tandhavadhana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Colchicine Content in Gloriosa superba L., Root after Pretreatment by Thai Traditional Medicine Methods</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Colchicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Gloriosa superba L.</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pretreatment methods</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">942-948</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In Thai traditional medical practice, the roots of Gloriosa superba L. must be treated prior to use as Thai herbal remedies. Colchicine is a major active chemical constituent in the roots. It was reported that lethal doses of colchicine were 7-26 mg. There have been two pieces of evidence that indicated 5 different pretreatment methods of Gloriosa superba L., roots. Therefore, this research aimed to compare the amount of colchicine before and after pre-treated by 5 different methods and compare colchicine content after pretreatment between methods. &lt;strong&gt;Methods:&lt;/strong&gt; Provide five different locations of fresh Gloriosa superba L., roots. Each sample divided into 6 groups. The first group would be treated as a control, the second to the sixth group was pre-treated by roasting, burning, boiling, stewing, and grilling which follow the methods from two pieces of evidence. Subsequently, quantitative analysis by High Performance Liquid Chromatography. &lt;strong&gt;Results: &lt;/strong&gt;The amount of colchicine in roots before and after pre-treated by roasting, burning, boiling, stewing, and grilling methods were significantly reduced by 45.61±10.61% (&lt;em&gt;p&lt;/em&gt;=0.000), 37.35±14.15% (&lt;em&gt;p&lt;/em&gt;=0.000), 44.55±8.60% (&lt;em&gt;p&lt;/em&gt;=0.000), 76.40±10.70% (&lt;em&gt;p&lt;/em&gt;=0.000), and 30.35±11.31% (&lt;em&gt;p&lt;/em&gt;=0.000), respectively. The stewing method was the greatest decrease amount of colchicine which significantly different from other methods. (&lt;em&gt;p&lt;/em&gt;=0.000).&lt;strong&gt; Conclusion: &lt;/strong&gt;All 5 methods were significantly reduced amounts of colchicine in the roots of Gloriosa superba L. They were effective methods to pre-treat the roots of Gloriosa superba L. prior to use as Thai herbal remedies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">942</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sasithorn Tandhavadhana*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Science, Ramkhamhaeng University, Bangkok 10240, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Pholawat Tingpej</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author><author><style face="normal" font="default" size="100%">Thanes Fuangfoo</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aporosa villosa Stem Ethanolic Extract on Adipogenesis in 3T3-L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aporosa villosa; Adipogenesis; Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1422-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: An excessive fat accumulation is related to development of obesity. Obesity is associated with the induction of insulin resistance and diabetes mellitus conditions. &lt;em&gt;Aporosa villosa &lt;/em&gt;is a plant that found in the Northern and Northeastern region of Thailand.&lt;strong&gt; Objective: &lt;/strong&gt;The present study used 3T3-L1 adipocytes for investigating the effect of &lt;em&gt;Aporosa villosa&lt;/em&gt; stem ethanolic extract (AS) on adipogenesis. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: 3T3-L1 adipocytes were used for measuring the cytotoxicity of AS at a concentration range of 3-100 μg/mL. After adipocyte cells treated with AS (3-100 μg/mL) for 8 days, the lipid accumulation was detected by Oil Red O staining and adipogenic gene expression were determined by quantitative real-time PCR. &lt;strong&gt;Results: &lt;/strong&gt;AS extracts (3-100 μg/mL) did not show cytotoxicity on cell proliferation. After 8 days of treating 3T3-L1 adipocytes with AS at doses of 3, 10, 30 and 100 μg/mL, the lipid droplets were reduced as compared to non-treated cells. Furthermore, the adipogenic genes were measured. The regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferatoractivated receptor γ (PPARγ) and sterol regulatory element binding protein 1c (SREBP1c) were found decreasing in AS extracts. The downstream target genes of these regulators cluster of differentiation (CD) 36, fatty acid synthase (FAS) and lipoprotein lipase (LPL) were also reduced by AS treatments. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings indicate that AS extract has an inhibitory activity on adipogenesis in 3T3-L1 adipocytes via suppressing C/EBPα, PPARγ and SREBP1c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Pholawat Tingpej&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3&lt;/sup&gt;, Thanes Fuangfoo&lt;sup&gt;4 &lt;/sup&gt;&amp;nbsp;Jarinyaporn Naowaboot&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Natasha Yemima Situmorang</style></author><author><style face="normal" font="default" size="100%">Endah Zuraidah</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Mahkota Dewa (Phaleria macrocarpa) Leaf Extract on the Mucin 1 Expression in Mice Colonic Epithelial Cells Induced by Dextran Sodium Sulfate (DSS)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon epithelial cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory bowel Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahkota Dewa (Phaleria macrocarpa)</style></keyword><keyword><style  face="normal" font="default" size="100%">MUC 1 expression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1509-1515</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Inflammatory bowel disease is a chronic inflammation caused by the malignant inflammation response and if not treated, could lead to colorectal cancer. One of the researched treatment is mahkota dewa (&lt;em&gt;Phaleria macrocarpa&lt;/em&gt;) leaf extract that has flavonoid compound known to reduce inflammation. This study was aimed to prove that mahkota dewa leaf extract could reduce inflammation of mice colon induced with dextran sodium sulfate (DSS) and observe MUC1 expression from colon epithelial crypt of Lieberkuhn. &lt;strong&gt;Methods&lt;/strong&gt;: This was a laboratory experiment using biological material (paraffin block) taken from 28 mice and divided into 5 groups: normal, aspirin, low and high dose mahkota dewa, and negative control. They were processed into immunohistochemistry and stained microscopic slides. Afterwards, they were observed with 400x magnification and 5 field-of-view of mice colon crypt of lieberkuhn. Then MUC1 expression was counted using ImageJ to obtain mean immunohistochemistry score and analyzed with SPSS. &lt;strong&gt;Results:&lt;/strong&gt; There were significant reduction of MUC1 expressions from normal, aspirin, and high dose mahkota dewa groups compared to the negative control group. The result shown MUC1 expression from high dose mahkota dewa (M=149.90,SD=3.81) and aspirin (M=158.92,SD=5.28) were closer to normal group (M=148.02,SD=5.28). There were no significant results between negative (M=175.39,SD=14.30) and low dose mahkota dewa group (M=149.90,SD=5.02).&lt;strong&gt; Conclusion:&lt;/strong&gt; There was a reduction of MUC1 expression in DSS-induced mice colonic epithelial cells for high dose mahkota dewa group. This shown that high dosage mahkota dewa leaf extract could reduce inflammation like aspirin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1509</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-3,*&lt;/sup&gt;, Natasha Yemima Situmorang&lt;sup&gt;4&lt;/sup&gt;, Endah Zuraidah&lt;sup&gt;5&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;6&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine – Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thanh Ha Tuan Nguyen</style></author><author><style face="normal" font="default" size="100%">Ngan Nguyen Hoang</style></author><author><style face="normal" font="default" size="100%">Xuan Thanh Nguyen</style></author><author><style face="normal" font="default" size="100%">Binh Nhu Do</style></author><author><style face="normal" font="default" size="100%">Son Trinh The</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluate the Effect of Herbal Extract Remedy for Treatment of Liver Cirrhosis in in-vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CCl4</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cirrhosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">XGTQ herbal extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">189-195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the in-vitro effect of herbal extract recepies, namely XGTQ, in the treatment of liver cirrhosis that induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet in rats. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Liver cirrhosis was induced by subcutaneously injecting CC14 (initial dose of 5,0ml/kg, followed by 1,2ml/kg twice a week in 10 weeks) in winstar rats. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered a day with fresh water and water mixed with 30% ethanol in another day. The rats were randomly divided into 5 groups and given distilled water (group 1 or control group and group 2 or cirrhosis group), silymarin (group 3 or reference group) or the herbal recipes, aka XGTQ, drug extract (group 4, 5) for 4 weeks. Blood was collected for biochemical test and livers were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.&lt;strong&gt; Results: &lt;/strong&gt;In cirrhotic wistar rats, the XGTQ herbal drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the level of enzymes AST, ALT in the blood (p&amp;lt;0.01), increasing plasma albumin and decreasing prothrobin time (p&amp;lt;0.05); improving physical condition, macroscopic and microscopic images of H&amp;amp;E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effect of herbal recipes XGTQ increased dramatically with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. &lt;strong&gt;Conclusion: &lt;/strong&gt;The aqueous extract of XGTQ herbal remedy has have a good effect in treatment of liver cirrhosis in in-vitro and to be equivalent to that of silymarin at the dose of 70 mg/kg.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">189</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thanh Ha Tuan Nguyen&lt;sup&gt;1,2,#&lt;/sup&gt;, Ngan Nguyen Hoang&lt;sup&gt;1,#&lt;/sup&gt;, Xuan Thanh Nguyen&lt;sup&gt;1,2&lt;/sup&gt;, Binh Nhu Do&lt;sup&gt;1,2&lt;/sup&gt;, Son Trinh The&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Military Hospital 103, No.261 Phung Hung st, Phuc La, Ha Dong, Ha Noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work and are co‐first authors&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neeraj Choudhary</style></author><author><style face="normal" font="default" size="100%">Pranav Kumar Prabhakar</style></author><author><style face="normal" font="default" size="100%">Gopal L Khatik</style></author><author><style face="normal" font="default" size="100%">Subba Rao Chamakuri</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Ashish Suttee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Acute toxicity, In-vitro, In-vivo Antidiabetic Potential of the Flavonoid Fraction of the plant Chenopodium album L</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chenopodium album</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">765-779</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The &lt;em&gt;Chenopodium album &lt;/em&gt;L. commonly recognized as Bathua, is widely distributed globally and contains various phytoconstituents that help treat several diseases. However, until now, aerial parts' antidiabetic potential and the plant's acute toxicity at fraction level have never been established. &lt;strong&gt;Objectives: &lt;/strong&gt;To investigate the acute toxicity, the&lt;em&gt; in-vitro&lt;/em&gt;,&lt;em&gt; in-vivo&lt;/em&gt; antidiabetic potential of the plant at fraction level. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The aerial parts of the plant were fractionated into different fractions, i.e., flavonoid fraction (CAFF), tannin fraction (CATF), alkaloid fraction (CAAF), saponin fraction (CASF), and were analyzed for&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay. The CAFF, CATF, and CAAF were selected based on&lt;em&gt; in-vitro &lt;/em&gt;alpha-amylase inhibition assay results and were further screened for its acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antidiabetic activity using a high-fat diet and streptozotocin-induced diabetes model. The CAFF was characterized by LC-MS, and a molecular docking study was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;in-vitro &lt;/em&gt;alpha-amylase inhibition assay revealed that CAFF was found to be more potent than standard Acarbose having IC&lt;sub&gt;50&lt;/sub&gt; values 122.18 ± 1.15 and 812.83± 1.07 μg/ml, respectively. The CAFF fraction was found to possess potent antidiabetic activity in a dose-dependent manner in both in vitro and &lt;em&gt;in vivo &lt;/em&gt;diabetic models and did not produce any sign of severe toxicity. Furthermore, the bioactive CAFF fraction was characterized by LC-MS, showed the presence of quercetin 3-O-(2’’,6’’-di-O-rhamnosyl) glucoside (QRG) or quercetin 3-O-(2’’,6’’-di-Orhamnosyl) galactoside (QRGa) and quercetin 3-O-rutinoside (rutin) (QR). It is predicted from the molecular docking study that the CAFF fraction primarily acts as an alphaamylase inhibitor. &lt;strong&gt;Conclusion:&lt;/strong&gt; The CAFF fraction was found to poses dose-dependent potent antidiabetic activity and did not produce any sign of severe toxicity and primarily act as an alpha-amylase inhibitor.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">765</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Neeraj Choudhary&lt;sup&gt;1,2&lt;/sup&gt;, Pranav Kumar Prabhakar&lt;sup&gt;1&lt;/sup&gt;, Gopal L. Khatik&lt;sup&gt;1&lt;/sup&gt;, Subba Rao Chamakuri&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;1&lt;/sup&gt;, Ashish Suttee&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmaceutical Sciences, Lovely Professional University, Punjab, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana, Punjab, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Maribel Herrera-Ruiz</style></author><author><style face="normal" font="default" size="100%">María del Carmen Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Vera Petricevich</style></author><author><style face="normal" font="default" size="100%">María Angélica Santana</style></author><author><style face="normal" font="default" size="100%">Martha Navarro</style></author><author><style face="normal" font="default" size="100%">Angélica Berenice Aguilar-Guadarrama</style></author><author><style face="normal" font="default" size="100%">Gabriel Navarrete-Vázquez</style></author><author><style face="normal" font="default" size="100%">Irene Perea-Arango</style></author><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Anticonvulsant, Anxiolytic, Sedative, and Neuroprotective Activities of Polysaccharides from Mycelium of Two Ganoderma Species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">a- and b-glucan</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">GABA</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtissi</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma sp</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1161-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ganoderma lucidum&lt;/em&gt; has been used as a medicinal mushroom since centuries in East Asia. Recent reports have shown that metabolites isolated from &lt;em&gt;Ganoderma&lt;/em&gt; species have shown effects on central nervous system. &lt;strong&gt;Objective:&amp;nbsp;&lt;/strong&gt;To determine the neuroprotective, anticonvulsant, anxiolytic, and sedative effects of &lt;em&gt;Ganoderma &lt;/em&gt;sp. and &lt;em&gt;Ganoderma curtisii&lt;/em&gt; polysaccharides. &lt;strong&gt;Methods:&lt;/strong&gt; Polysaccharides (Gsp-PS2 or Gc-PS2) were isolated from two &lt;em&gt;Ganoderma mycelia&lt;/em&gt; submerged cultures. Acute toxicity effects of Gc-PS2 or Gsp-PS2 on mice were treated orally with doses of 50 - 2000 mg/kg. Anticonvulsant activity was determined using three chemoconvulsants: kainic acid (KA), strychnine, or pentylenetetrazole (PTZ). Anxiolytic-like effects were determined using the elevated plus maze test on mice. GABA release evoked by GC-PS2 or Gsp-PS2 content was determined by HPLC. Neuroprotective effects of Gsp-PS2 or Gc-PS2 were determined by glial activation, histopathological changes, and immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; Gc-PS2 or Gsp-PS2 showed neuroprotective activity by diminishing neuronal death, reducing glial activation and Neu-N expression levels. Gsp-PS2 or Gc-PS2 inhibited convulsions in the KA model. An anxiolytic-like, but not a sedative effect was reported in mice treated with Gc-PS2 or Gsp-PS2. Polysaccharides Gc-PS2 or Gsp-PS2 evoked endogenous GABA release and increased its concentration within the incubation medium. Pretreatment with Gsp-PS2 or Gc-PS2 showed a reduction of the LPSinduced NO production. Gc-PS2 or Gsp-PS2 did not produce toxic effects. &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;&lt;em&gt;Ganoderma &lt;/em&gt;sp. or &lt;em&gt;Ganoderma curtisii &lt;/em&gt;polysaccharides showed neuroprotective and anticonvulsant activities in animal models. The anticonvulsant activity may involve the GABAergic neurotransmision.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1161</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Verónica Núñez-Urquiza,&lt;sup&gt;1&lt;/sup&gt; Juana Villeda- Hernández,&lt;sup&gt;2&lt;/sup&gt; Elizur Montiel-Arcos,&lt;sup&gt;3&lt;/sup&gt; Isaac Tello,&lt;sup&gt;3&lt;/sup&gt; Victoria Campos-Peña,&lt;sup&gt;2&lt;/sup&gt; Maribel Herrera-Ruiz,&lt;sup&gt;4&lt;/sup&gt; María del Carmen Gutiérrez,&lt;sup&gt;5&lt;/sup&gt; Vera Petricevich,&lt;sup&gt;6&lt;/sup&gt; María Angélica Santana,&lt;sup&gt;7&lt;/sup&gt; Martha Navarro,&lt;sup&gt;2&lt;/sup&gt; Angélica Berenice Aguilar-Guadarrama,&lt;sup&gt;1&lt;/sup&gt; Gabriel Navarrete-Vázquez,&lt;sup&gt;8&lt;/sup&gt; Irene Perea- Arango,&lt;sup&gt;5&lt;/sup&gt; Ismael León-Rivera&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Centro de Investigación en Biotecnología, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Centro de Investigación en Dinámica Celular, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">Latifa El Hafid</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author><author><style face="normal" font="default" size="100%">Mohammed Reda Tazi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolution of Biometric Parameters and Oil Fatty Acid Composition of Argan &quot;Argania spinosa L. Skeels&quot; Fruits from Beni- Snassen (Eastern Region of Morocco) During Ripening</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argan fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Beni-Snassen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biometeric parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripeness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">296-308</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Argania spinosa&lt;/em&gt; Skeels is an endemic forest essence of Morocco. The argan of the north-east of Morocco remains a virgin subject of study without enough value given to it. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study is to asses the evolution of biometric parameters and fatty acids composition of the argan fruits from Beni-Snassen region during ripening. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;4 fruit shapes harvested over seven months were characterized through the measurement of their biometric parameters (size and weight), and their composition of majority fatty acids. &lt;strong&gt;Results: &lt;/strong&gt;the studied argan tree could be classified into two major groups, namely: early-riped trees with oval or oval-apiculate fruits and late-riped trees with fusiform or spherical fruits. When considering the fruits size and weight, the highest values were recorded on late-ripened fruits, more particularly fusiform shapes. The obtained results showed, on one hand, a significant difference in the unsaturated fatty acids, according to the fruit ripeness stage and shapes, being the later significantly affecting the stearic acid content; and on another hand, it was noted an increase of oleic acid content while linoleic acid decreased. In the maturation stage, the spherical shaped fruits were found to have the highest ratio of unsaturated/saturated fatty acids.&lt;strong&gt; Conclusion:&lt;/strong&gt; The results demonstrated the possibility to predict the kernel’s weight from the fruit’s length. The results also showed the good dietary and nutritional quality of spherical shapes and that the biometric parameters are important criteria for the differentiation of argan tree fruits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdelhak Chergui&lt;sup&gt;1,&lt;/sup&gt;*, Latifa El Hafid&lt;sup&gt;2&lt;/sup&gt;, El Amine Ajal&lt;sup&gt;1&lt;/sup&gt;, Imane Zakariya&lt;sup&gt;1&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;, Mohammed Reda Tazi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Mohammed V University, Faculty of Medicine and Pharmacy, Av. Mohammed Belarabi El Alaoui, BP 6203- Rabat institut-Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Improving Agricultural Productivity, Biotechnology &amp;amp; Environment, Mohammed I University, Faculty of Science, Blvd. Mohammed VI, BP 717-Oujda, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Regional Center of professions of Education and Training of the Orient- Oujda, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Alisa Kamarudin</style></author><author><style face="normal" font="default" size="100%">Norhazilah Muhamad</style></author><author><style face="normal" font="default" size="100%">Nik Nur Hakimah Nik Salleh</style></author><author><style face="normal" font="default" size="100%">Suat Cheng Tan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Solvent Selection on Phytochemical Content, Recovery of Tannin and Antioxidant Activity of Quercus Infectoria Galls</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallotannin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercus infectoria (QI) galls</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1195-1204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Quercus infectoria &lt;/em&gt;(QI) is medicinal plant well known to exhibit enormous therapeutic values. The main medicinal part of QI plant exists in its edible nutritious gall. This study aimed to determine the effects of extraction solvents on the overall phytochemical content, recovery of tannin and antioxidant activity of the QI galls. &lt;strong&gt;Methods: &lt;/strong&gt;Two solvents of different polarity namely water and methanol, were used to extract bioactive compounds from the QI galls using soxhlet extraction technique. Phytochemical, TLC and HPLC assays were performed to detect and quantify the extracted compounds. DPPH assay was conducted to evaluate the antioxidant potential of the extracted compounds. &lt;strong&gt;Results:&lt;/strong&gt; After 6 hours of extraction at respective solvent boiling points, methanol solvent successfully generated 1.8-fold higher crude yield (34.0%) compared to water solvent (18.9%). Phytochemical analysis revealed that both solvent extracts contained different secondary metabolites. The methanol extract was found richer in flavonoid, while the aqueous extract was found richer in phenol, tannin, gallotannin, triterpene and cardiac glycosides. Interestingly, we found that the major type of tannin presence in QI galls was gallotannin (hydrolysable tannin) instead of phlobatannin (non-hydrolysable tannin). The quantification results demonstrated that QI aqueous extract contained significantly higher gallotannin (75.0 μg/mL) compared to QI methanol extract (46.8 μg/mL). Furthermore, the aqueous extract also exhibited significant higher antioxidant activity compared to the methanol extract at concentration of 2 μg/mL. &lt;strong&gt;Conclusions:&lt;/strong&gt; This study strongly support the utilization of water solvent for optimum gallotannin extraction from QI galls.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Alisa Kamarudin&lt;sup&gt;1&lt;/sup&gt;, Norhazilah Muhamad&lt;sup&gt;1,2&lt;/sup&gt;, Nik Nur Hakimah Nik Salleh&lt;sup&gt;1&lt;/sup&gt;, Suat Cheng Tan&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Medical Campus, University Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olivia Mahardani Adam</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author><author><style face="normal" font="default" size="100%">Mohammad Hasan Machfoed</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Study on the Promising Active Components of Terpenoid and Fucoidon from Sargassum sp. in Inhibiting CGRP and TNF-α</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CGRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidone</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum sp.</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoid</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1715-1719</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The new discovery of the active substance in &lt;em&gt;Sargassum&lt;/em&gt; sp marks the new era for drug industry as it is very effective as the new migraine medication compared to analgesics which have already been popular previously in treating migraine. By using the&lt;em&gt; in silico&lt;/em&gt; methods, this study intended to identify the preventive effect of the active substance in &lt;em&gt;Sargassum &lt;/em&gt;sp within the stage of pain and inflammation development in migraine. In migraine pathophysiology, the clinical findings would build and verify the role of CGRP and TNF-α. &lt;strong&gt;Methods:&lt;/strong&gt; This research applied a one-shot experimental study and by employing the potential test through PubChem (https://pubchem.ncbi.nlm.nih.gov/), the result of this study proved that tannins, terpenoids and fucoidone were contained in the active substance of &lt;em&gt;Sargassum &lt;/em&gt;sp leading to the possession of potential as the drug to treat migraine. &lt;strong&gt;Results:&lt;/strong&gt; Terpenoids and tannin binding affinity value is higher than other substances. Terpenoids and fucoidon had similar amino acid residues with controls. Seaweed metabolites have great potential as inhibitors of CGRP and TNF-α because the binding affinity score is close to control. &lt;strong&gt;Conclusion: &lt;/strong&gt;The active substance in &lt;em&gt;Sargassum &lt;/em&gt;sp has an inhibitory effect on the occurrence of CGRP and TNF-α in migraine based on in silico studies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1715</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olivia Mahardani Adam&lt;sup&gt;1,&lt;/sup&gt;*, Jusak Nugraha&lt;sup&gt;2&lt;/sup&gt;, Mohammad Hasan Machfoed&lt;sup&gt;3&lt;/sup&gt;, Agus Turchan&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sueptrakool Wisessombat</style></author><author><style face="normal" font="default" size="100%">Malatee Tayeh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Wound Healing Potential and Antimicrobial Activity of Clerodendrum Inerme Leave Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Clerodendrum inerme</style></keyword><keyword><style  face="normal" font="default" size="100%">Keratinocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Scratch assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1542-1548</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Clerodendrum inerme &lt;/em&gt;is a medicinal plant which exhibited many pharmacological effects. However, wound healing property of this plant has not been investigated. &lt;strong&gt;Objective&lt;/strong&gt;: The present study was designed to evaluate wound healing and antimicrobial activities of &lt;em&gt;C. inerme&lt;/em&gt; leaves using the &lt;em&gt;in vitro &lt;/em&gt;model with Human keratinocytes (HaCaT). &lt;strong&gt;Methods&lt;/strong&gt;: Cytotoxicity and wound healing effects were determined by MTT and scratch wound healing assay. Antimicrobial activities against cutaneous flora and clinical isolates of bacteria were investigated by broth microdilution assay. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that the water extract of &lt;em&gt;C. inerme&lt;/em&gt; leaves did not exhibit cytotoxic effects on HaCaT cells, while ethanol extracts at higher concentrations significantly decreased cell growth with an IC&lt;sub&gt;50&lt;/sub&gt; value of 386.8 ± 87.1 μg/mL. The water extract and the lowest concentration (6.25 μg/mL) of the ethanol extract significantly increased percentage of wound closure compared with the untreated group. The water and ethanol extracts of &lt;em&gt;C. inerme&lt;/em&gt; displayed a broad spectrum of antibacterial activity, inhibiting growth of Staphylococcus aureus, &lt;em&gt;Staphylococcus.epidermidis,&lt;/em&gt; &lt;em&gt;Escherichia coli,&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginosa.&lt;/em&gt; The water extract displayed remarkable activity against methicillin-resistant S. aureus with MIC and MBC values ranging from 0.39 to 1.56 μg/mL. Notably, it provided stronger antibacterial activity than vancomycin and also showed antifungal activity against&lt;em&gt; C. albicans. &lt;/em&gt;&lt;strong&gt;Conclusion:&lt;/strong&gt; This study confirms the potential of &lt;em&gt;C. inerme &lt;/em&gt;leaves for wound healing and antimicrobial therapy and supports the continued utilization of &lt;em&gt;C. inerme&lt;/em&gt; leaves in traditional medicine. Further studies are needed to clarify the molecular mechanisms through which it exerts such biological effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sueptrakool Wisessombat&lt;sup&gt;1&lt;/sup&gt;, Malatee Tayeh&lt;sup&gt;1,2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Food Technology and Innovation Center of Excellence, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Coronado-Olano</style></author><author><style face="normal" font="default" size="100%">Ritva Repo-Carrasco-Valencia</style></author><author><style face="normal" font="default" size="100%">Oscar Reategui</style></author><author><style face="normal" font="default" size="100%">Emily Toscano</style></author><author><style face="normal" font="default" size="100%">Elisa Valdez</style></author><author><style face="normal" font="default" size="100%">Mirko Zimic</style></author><author><style face="normal" font="default" size="100%">Ivan Best</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory activity against α-amylase and α-glucosidase by phenolic compounds of quinoa (Chenopodium quinoa Willd.) and cañihua (Chenopodium pallidicaule Aellen) from the Andean region of Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andean grains</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">896-901</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Chenopodium quinoa&lt;/em&gt; Willd. and &lt;em&gt;Chenopodium pallidicaule&lt;/em&gt; Aellen are grains from the Andean region of Peru, which in addition to having a high nutritional value, have health-promoting properties related to the prevention of chronic diseases such as diabetes. &lt;strong&gt;Objetive:&lt;/strong&gt; The present study aimed to identify phenolic compounds associated with an inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Two varieties of quinoa and two varieties of cañihua from the Puno Region in Peru, were evaluated. Total phenolics, total flavonoids, identification of phenolic compounds and antioxidant activity &lt;em&gt;in vitro&lt;/em&gt; were measured by Folin-Ciocalteu assay, aluminum chloride colorimetric method, HPLC-DAD and DPPH radical scavenging assay, respectively. &lt;em&gt;In vitro &lt;/em&gt;hypoglycemic activity was evaluated through the inhibition of the α-amylase and α-glucosidase enzymes. Results: Gallic acid, rutin and chlorogenic acid were identified by HPLC-DAD in the varieties of quinoa and cañihua. The latter showed significantly higher levels of chlorogenic acid compared to quinoa varieties (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Both Andean grains exhibited inhibition of key-enzymes linked to type 2 diabetes, presenting IC&lt;sub&gt;50&lt;/sub&gt; values of 7.99 to 34.05 and of 8.07 to 1158 μg/mL for α-amylase and α-glucosidase, respectively. Total phenolics, total flavonoids, DPPH radical scavenging assay, gallic acid and chlorogenic acid showed the greatest contribution to the inhibitory activity of the α-glucosidase enzyme (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our findings suggest that the phenolic compounds present in the varieties of quinoa and cañihua could modulate the inhibition of carbohydrate hydrolyzing enzymes associated with type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">896</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Coronado-Olano&lt;sup&gt;1,5&lt;/sup&gt;, Ritva Repo-Carrasco-Valencia&lt;sup&gt;1&lt;/sup&gt;, Oscar Reategui&lt;sup&gt;2&lt;/sup&gt;, Emily Toscano&lt;sup&gt;3&lt;/sup&gt;, Elisa Valdez&lt;sup&gt;4&lt;/sup&gt;, Mirko Zimic&lt;sup&gt;3&lt;/sup&gt;, Ivan Best&lt;sup&gt;6,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Industrias Alimentarias, Universidad Nacional Agraria La Molina, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Carrera de Ingeniería Agroforestal, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Bioinformática y Biología Molecular, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Nacional Federico Villarreal, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hersil S. A. Laboratorios Industriales Farmacéuticos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Unidad de Investigación en Nutrición, Salud, Alimentos Funcionales y Nutracéuticos, Universidad San Ignacio de Loyola (UNUSANUSIL), Calle Toulon 310, 15024 Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mochamad Yusuf Alsagaff</style></author><author><style face="normal" font="default" size="100%">Melly Susanti</style></author><author><style face="normal" font="default" size="100%">Mochammad Thaha</style></author><author><style face="normal" font="default" size="100%">Christian Jonatan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inotropes in Chronic Beta-Blocker Therapy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Beta-blocker</style></keyword><keyword><style  face="normal" font="default" size="100%">Decompensated heart failure</style></keyword><keyword><style  face="normal" font="default" size="100%">Inotropes</style></keyword><keyword><style  face="normal" font="default" size="100%">Severe sepsis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">828-834</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The increasing rate of cardiovascular disorders contributes to rising hospitalized patients receive chronic oral beta-blocker therapy. Beta-blockers remain one of the fundamental therapy for chronic heart failure. Still, their role in decompensated heart failure and severe sepsis during hospitalization is often debated and inconsistent in clinical practice. In recent years, evidence of the efficacy and clinical outcomes of beta-blockers in acute heart failure (AHF) have accumulated. Clinical research indicates that chronic beta-blockade withdrawals should be prevented, or as soon as hemodynamic stabilization and euvolemic condition are reached, it should be reinstituted. As a subset of AHF patients with low cardiac output required inotropes, the choice of proper agent is fundamental. Different inotropic agents such as inhibitors of the phosphodiesterase, levosimendan, and dobutamine also their associations with beta-blockers are discussed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mochamad Yusuf Alsagaff&lt;sup&gt;1,&lt;/sup&gt;*, Melly Susanti&lt;sup&gt;1&lt;/sup&gt;, Mochammad Thaha&lt;sup&gt;2&lt;/sup&gt;, Christian Jonatan&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Prof Moestopo Street 6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Prof Moestopo Street 6-8, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Xuan Phong Pham</style></author><author><style face="normal" font="default" size="100%">Tran Thi Tuyet Nhung</style></author><author><style face="normal" font="default" size="100%">Hoai Nam Trinh</style></author><author><style face="normal" font="default" size="100%">Do Minh Trung</style></author><author><style face="normal" font="default" size="100%">Dang Truong Giang</style></author><author><style face="normal" font="default" size="100%">Binh Duong Vu</style></author><author><style face="normal" font="default" size="100%">Nguyen Trọng Diep</style></author><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Van Thu Nguyen</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Structural Characterization of Compounds from Blumea lacera</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Blumea lacera</style></keyword><keyword><style  face="normal" font="default" size="100%">Column chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">999-1004</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The medicinal plants consider as a rich resource of ingredients which can be used in drug development and synthesis. Blumea lacera (Burm. f.) DC. is generally used in traditional medicine for the treatment of cough, bronchitis, dysentery, wound healing. The aim of this study is to isolate and identify the compounds from the aerial parts of Blumea lacera. &lt;strong&gt;Methods:&lt;/strong&gt; The aerial parts of B. lacera were dried, powdered and extracted using EtOH, and the concentrated extract was partitioned in succession with n-hexane, CH&lt;sub&gt;2&lt;/sub&gt;Cl&lt;sub&gt;2&lt;/sub&gt;, and EtOAc. From the EtOAc fraction, the compounds were isolated through column chromatography and their chemical structures were elucidated by NMR spectroscopy and confirmed by comparison of their NMR data with literature data. &lt;strong&gt;Results:&lt;/strong&gt; Repeated column chromatography of the EtOAc-soluble fraction from the aerial parts of B. lacera resulted in the isolation of β-sitosterol (1), campesterol (2), artemetin (3) and acid paracatechuic (4).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">999</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Xuan Phong Pham&lt;sup&gt;1,&lt;/sup&gt;#, Tran Thi Tuyet Nhung&lt;sup&gt;1,&lt;/sup&gt;#, Hoai Nam Trinh&lt;sup&gt;1&lt;/sup&gt;, Do Minh Trung&lt;sup&gt;4&lt;/sup&gt;, Dang Truong Giang&lt;sup&gt;2&lt;/sup&gt;, Binh Duong Vu&lt;sup&gt;2&lt;/sup&gt;, Nguyen Trọng Diep&lt;sup&gt;3&lt;/sup&gt;, Nguyen Van Long&lt;sup&gt;3&lt;/sup&gt;, Van Thu Nguyen&lt;sup&gt;3,&lt;/sup&gt;*, Chu Van Men&lt;sup&gt;4,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Military Institute of Traditional Medicine, 442 Kim Giang, Hoang Mai, Ha Noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;The Drug R&amp;amp;D Center, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Pharmaceutical Education, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 160 Phung Hung, Ha Dong, Hanoi, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mithila Jayasundera</style></author><author><style face="normal" font="default" size="100%">Singarayer Florentine</style></author><author><style face="normal" font="default" size="100%">Kushan U Tennakoon</style></author><author><style face="normal" font="default" size="100%">Bhagirath Singh Chauhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Value of Three Agricultural Weed Species of the Asteraceae Family: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Bidens pilosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional use</style></keyword><keyword><style  face="normal" font="default" size="100%">Tridax procumbens</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">264-277</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ageratum conyzoides &lt;/em&gt;L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa&lt;/em&gt; L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on &lt;em&gt;Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and&lt;em&gt; Bidens pilosa&lt;/em&gt; L., which we note are widely spread throughout the world. This study was conducted through a coherent search on&lt;em&gt; Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa &lt;/em&gt;L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A&lt;em&gt;. conyzoides, T. procumbens&lt;/em&gt; and &lt;em&gt;B. pilosa&lt;/em&gt;) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">264</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mithila Jayasundera&lt;sup&gt;1&lt;/sup&gt;, Singarayer Florentine&lt;sup&gt;2,&lt;/sup&gt;*, Kushan U Tennakoon&lt;sup&gt;3&lt;/sup&gt;, Bhagirath Singh Chauhan&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, RMIT University, Bundoora West Campus, Bundoora, VIC 3083, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, Mt Helen Campus, Ballarat, VIC 3353, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, No.100 Clyde Road, Berwick, VIC 3806, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Gatton, QLD 4343, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rani Wardani Hakim</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Tri Juli Edi Tarigan</style></author><author><style face="normal" font="default" size="100%">Sri Widia A Jusman</style></author><author><style face="normal" font="default" size="100%">Erni H Purwaningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Study of Acalypha indica to Leptin, Alpha Glucosidase, and its Antihyperglycemic Effect on Alpha Glucosidase</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acalypha indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha glucosidase.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiobesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1639-1647</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The purpose of this study is to find potential inhibitors of leptin as a proinflammatory adipokine and alpha glucosidase as an enzyme that mediate hyperglycaemia; to alter the chronic complications of obesity from herbal Acalypha indica (Ai). This study was conducted using in silico molecular docking to evaluate the Ai compounds interaction with leptin and alpha glucosidase. The in vitro assay to alpha glucosidase was done to explore antihyperglycemic effect of Ai, as hyperglycaemia is the key process of chronic complication of obesity. &lt;strong&gt;Material and&lt;/strong&gt; &lt;strong&gt;Methods: &lt;/strong&gt;Protein target were leptin and alpha glucosidase; compounds from Ai plant were repundusinic, mauritanin, hesperetin, acaindinin, and glucogalin in pdb format. Molecular docking using autodock vinna. In vitro assay of Ai antihyperglycemic activity was done to alpha glucosidase and was define as IC50 level. &lt;strong&gt;Result:&lt;/strong&gt; The results from the docking analysis demonstrated that compounds from Ai roots contain antihyperglycemic-antiobesity activity which acted by inhibiting leptin and alpha glucosidase receptors. Repundusininc and mauritanin compounds contain hydrogen bond with the greatest leptin enhancer activity on Ser9, Thr35, Glu8, Ser9, Thr25, Gln111, Lys211, Leu7 for repundisinic and Glu8, Thr25, Gly112 and Leu7 for mauritanin. Hesperetin, acaindinin and glucogallin were the most identical compounds with similar affinity binding value to alpha glucosidase. Ai roots was already proven as anti-hyperglycemic-antiobesity which was further confirmed by in vitro assay to alpha glucosidase (IC50 19,429 μg/ml.). &lt;strong&gt;Conclusion:&lt;/strong&gt; The results demonstrated that Ai have anti hyperglycaemic-antiobesity effects and was found to be potentially as antihyperglycemic by in vitro assay to alpha glucosidase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1639</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rani Wardani Hakim&lt;sup&gt;1,2,6&lt;/sup&gt;,*, Fadilah Fadilah&lt;sup&gt;3,6,7&lt;/sup&gt;, Tri Juli Edi Tarigan&lt;sup&gt;4&lt;/sup&gt;, Sri Widia A Jusman&lt;sup&gt;5&lt;/sup&gt;, Erni H Purwaningsih&lt;sup&gt;2,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maria del Pilar Caramantin Soriano</style></author><author><style face="normal" font="default" size="100%">Flavia Schiappacasse</style></author><author><style face="normal" font="default" size="100%">Patricio Peñailillo</style></author><author><style face="normal" font="default" size="100%">Jaime Tapia</style></author><author><style face="normal" font="default" size="100%">Sergio Wehinger</style></author><author><style face="normal" font="default" size="100%">Camilo A Valenzuela-Vasquez</style></author><author><style face="normal" font="default" size="100%">Sarvia M Durán-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutritional and Functional Potential of Selliera radicans Cav., a Chilean Native Halophyte</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Goodeniaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Inulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Macro and Micronutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">341-346</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Selliera radicans&lt;/em&gt; was recognized as one of the foods consumed by the oldest human settlement in America (Monte Verde, Chile) that had a diet with a high component of plants.&lt;strong&gt; Objective: &lt;/strong&gt;This study aims at investigating nutritional and functional characteristics of&lt;em&gt; S. radicans&lt;/em&gt;, a native halophyte from Chile. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; An analysis of total protein, carbohydrate, ash, and moisture from &lt;em&gt;S. radicans&lt;/em&gt; leaves was performed, using standard methods. The content of macro and micronutrients was quantified by atomic absorption spectrometry. The inulin content was carried out based on the Seliwanoff reactions. &lt;em&gt;S. radicans&lt;/em&gt; leaves were extracted with methanol and the total content of phenolic and flavonoids and antioxidant activity were evaluated by spectroscopic method. &lt;strong&gt;Results:&lt;/strong&gt; Leaves from cultivated plants proved to be a suitable source of proteins (7.5 % on DW), ash (6.8 % on DW), and a wide range of macro and micronutrients, where Ca, K, and Na had the highest values. In addition, inulin (2.3% on DW), total phenolics (63.4 GAE/g LDW) and flavonoids (21.8 QE/g LDW), and antioxidant capacity (10 TE/g LDW) were noted. &lt;strong&gt;Conclusions:&lt;/strong&gt; According to the results, cultivated &lt;em&gt;S. radicans&lt;/em&gt; leaves are promising sources of food with beneficial health properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">314</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maria del Pilar Caramantin Soriano&lt;sup&gt;1,&lt;/sup&gt;*, Flavia Schiappacasse&lt;sup&gt;2&lt;/sup&gt;, Patricio Peñailillo&lt;sup&gt;3&lt;/sup&gt;, Jaime Tapia&lt;sup&gt;4&lt;/sup&gt;, Sergio Wehinger&lt;sup&gt;5&lt;/sup&gt;, Camilo A. Valenzuela-Vasquez&lt;sup&gt;2&lt;/sup&gt;, and Sarvia M. Durán-Peña&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Instituto de Química de Recursos Naturales, Universidad de Talca, Av. Lircay s/n, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Agrarias, Universidad de Talca, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Instituto de Ciencias Biológicas, Universidad de Talca, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Instituto de Química de Recursos Naturales, Universidad de Talca, Av. Lircay s/n, Talca, CHILE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias de la Salud, Departamento de Bioquímica Clínica e Inmunohematología, Universidad de Talca, Talca, CHILE.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lubsandorzhieva PB</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dashinamzhilov Zh.B</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Ferubko EV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Collection and Study of its Hepatoprotective Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatoprotective activity</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">713-721</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aim of this work is pharmacognostic study of herbal formulation consisting of elecampane rhizomes and roots (&lt;em&gt;Inula helenium&lt;/em&gt; L.), fruits of rose (&lt;em&gt;Rosa&lt;/em&gt; sp.) and hawthorn (&lt;em&gt;Crataegus&lt;/em&gt; sp.), leaves of pepper mint (&lt;em&gt;Mentha piperita&lt;/em&gt; L.) and cowberry leaves (&lt;em&gt;Vaccinium vitis-idaea&lt;/em&gt; L.), spiny eleuterococcus rhizomes and roots (&lt;em&gt;Eleutherococcus senticosus &lt;/em&gt;(Rupr.et Maxim.) Maxim., low cudweed herb (&lt;em&gt;Gnaphalium uliginosum&lt;/em&gt; L.s.l.) as well as determination of its hepatoprotective activity. &lt;strong&gt;Materials and methods: &lt;/strong&gt;An electron microscope, HPLC and methods of the State Pharmacopoeia of Russia were used in pharmacognostic study of herbal formulation. The hepatoprotective, antioxidant and choleretic activities of the herbal formulation were studied&lt;em&gt; in vivo&lt;/em&gt; model of liver damage induced by tetracycline hydrochloride and 40% ethanol. &lt;strong&gt;Results: &lt;/strong&gt;The content of biologically active substances (BAS) collected: essential oils - at least 0.30%; flavonoids in terms of luteolin - not less than 1.0%; ascorbic acid - not less than 0.5%; tannins - not less than 3.0%; arbutin - at least 0.4%; eleutheroside B - not less than 0.01%.It has been found that the course administration of herbal formulation to white Wistar rats with liver damage eliminates the prooxidant effect of tetracycline and ethanol, reduces the manifestation of cholestasis and increases the rate of bile secretion for 1-3 hours. &lt;strong&gt;Conclusion: &lt;/strong&gt;The herbal formulation has hepatoprotective activity, antioxidant, choleretic effect and stimulates regenerative and antitoxic processes in the liver in rats with a model of combined liver damage induced tetracycline and ethanol. The obtained research results argue the possibility of using herbal formulation for prevention and complex treatment of liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">713</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lubsandorzhieva PB&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dashinamzhilov Zh.B&lt;sup&gt;1&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;3&lt;/sup&gt;, Ferubko EV&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;All-Russian Research Institute of medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darunee Puangpronpitag</style></author><author><style face="normal" font="default" size="100%">Puangpaka Tankitjanon</style></author><author><style face="normal" font="default" size="100%">Adisak Sumalee</style></author><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Activities of the Seedling Extracts from Inca Peanut Plukenetia volubilis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Inca peanut seedling</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">52-58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Plukenetia volubilis&lt;/em&gt; L., Inca peanut is an oleaginous plant, widely cultivated as commercially in South East Asia, especially in Thailand. The oil from the seed plant is a greatest interesting a natural source. &lt;strong&gt;Objectives:&lt;/strong&gt; The aims of this study were investigated phytochemical screening, to evaluated the total flavonoids and phenolic compound contents as well as antioxidant activities of seedling extract from &lt;em&gt;P. volubilis. &lt;/em&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The dried &lt;em&gt;P. volubilis&lt;/em&gt; seedlings of 21 days growing period were extracted by using different solvent including aqueous (ASS), 50% ethanolic (HESS), and 95% ethanolic (ESS) extracts. The phytochemical screenings were determined on total phenolic compound (TPC) and flavonoid (TFC) contents. The antioxidation were tested by using 2,2-diphenyl-1-picrylhydrazy radical scavenging (DPPH), 2,2 -azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS&lt;sup&gt;+&lt;/sup&gt;) assay, and ferric reducing antioxidant power (FRAP). &lt;strong&gt;Results: &lt;/strong&gt;The results found that the ESS were significantly highest amount on total phenolic compound (23.0809±0.8632 mgGE/gExt ) and flavonoid (466.3839±1.5580 mgQE/gExt) contents. In this study, ascorbic acid (IC&lt;sub&gt;50 &lt;/sub&gt;=0.016±0.0003 mg/mL) and Trolox (IC&lt;sub&gt;50&lt;/sub&gt; =0.044±0.0008 mg/mL) as standard substances were showed more potent than all of the extracts from &lt;em&gt;P. volubilis &lt;/em&gt;seedlings. Surprisingly, the ESS has more potent on free radical scavenging higher than different solvents; DPPH=0.007± 0.001 (IC&lt;sub&gt;50&lt;/sub&gt;=mg/mL), ABTS= 1.4065± 0.0505 (IC&lt;sub&gt;50&lt;/sub&gt;=mg/mL),and FRAP= 74.4960± 2.6067 (mg=TE/gExt). &lt;strong&gt;Conclusion:&lt;/strong&gt; the plant seedling extracts composed with high amount of flavonoids and phenolic compound contents possess valuable to antioxidant activities. The seedling extracts from the plant could apply to supplementary food, cosmetic, pharmaceutical, and horticultural industries. Next study, chemical compositions, the major active compound(s), and biological activities will be clarified.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darunee Puangpronpitag&lt;sup&gt;1&lt;/sup&gt;, Puangpaka Tankitjanon&lt;sup&gt;2&lt;/sup&gt;, Adisak Sumalee&lt;sup&gt;2&lt;/sup&gt;, Ampa Konsue&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biomedical Research Unit, Faculty of Medicine, Mahasarakham University, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sukhothai Thammatirat Open University, Nonthaburi, 11120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Thai Traditional Medicinal Research Unit, Applied Thai Traditional Medical Program, Faculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amira Horchani</style></author><author><style face="normal" font="default" size="100%">Fadwa Chaabane</style></author><author><style face="normal" font="default" size="100%">Mahassen Barboura</style></author><author><style face="normal" font="default" size="100%">Imen Mokdad-Bzeouich</style></author><author><style face="normal" font="default" size="100%">Aimen Abbassi</style></author><author><style face="normal" font="default" size="100%">Amine Trabelsi</style></author><author><style face="normal" font="default" size="100%">Leila Chekir-Ghedira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry and Biological Evaluation of Daphne gnidium L. Butanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Daphne gnidium</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysosmal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide production.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1688-1693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Daphne gnidium &lt;/em&gt;L. (Thymelaeaceae) has been used in the Mediterranean basin to treat skin diseases, rheumatism and toothache.&amp;nbsp;&lt;strong&gt;Objective: &lt;/strong&gt;the aim of this study was to evaluate the biological activities of butanol extract from the &lt;em&gt;D. gnidium&lt;/em&gt; leaves. &lt;strong&gt;Methods: &lt;/strong&gt;A quantitative analysis by high‐performance liquid chromatography with a diode array detector (HPLC‐DAD) was performed. The antioxidant activities were evaluated by using three different assays: 2,2-diphenyl-l-picrylhydrazyl assay (DPPH assay), deoxyribose degradation assay and Cellular Antioxidant Activity (CAA) assay. The butanol extract was investigated for anti-inflammatory and analgesic activities in animal models. In addition, its effect on the production of NO and lysosomal activity &lt;em&gt;in vivo &lt;/em&gt;was assessed. &lt;strong&gt;Results: &lt;/strong&gt;The HPLC-DAD analysis showed the presence of daphnetin. The butanol extract had a remarkable antioxidant activity in the different systems tested. Furthermore, it has an anti-inflammatory effect by inhibiting the xyleneinduced ear edema and reduced the number of abdominal constrictions in mice indicating analgesic effect. It also was found to inhibit (NO) production and lysosomal activity &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings support the daphne use in traditional medicine for its analgesic and anti-inflammatory activities. Further investigations to elucidate its mechanism of action are required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amira Horchani&lt;sup&gt;1,&lt;/sup&gt;*, Fadwa Chaabane&lt;sup&gt;1&lt;/sup&gt;, Mahassen Barboura&lt;sup&gt;1&lt;/sup&gt;, Imen Mokdad-Bzeouich&lt;sup&gt;1&lt;/sup&gt;, Aimen Abbassi&lt;sup&gt;1&lt;/sup&gt;, Amine Trabelsi&lt;sup&gt;1&lt;/sup&gt;, Leila Chekir-Ghedira&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Unit of natural bioactive substances and biotechnology, Faculty of Pharmacy of Monastir, 5000, TUNISIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Cell and Molecular Biology, Faculty of Dental Medicine of Monastir,5000, TUNISA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Elvan Wiyarta</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Nurhuda Sahar</style></author><author><style face="normal" font="default" size="100%">Yurnadi Hanafi Midoen</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Alfred Pakpahan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Inhibition by Phaleria macrocarpa Leaves Ethanol Extract on Ki-67 Expression in Distal Colon Mouse</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulphate</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflamation</style></keyword><keyword><style  face="normal" font="default" size="100%">Ki- 67</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahkota Dewa (Phaleria macrocarpa)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">443-449</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ulcerative colitis (UC) has been an important aspect of an incurable chronic inflammatory disease over the last few decades. To find useful therapies for UC, one of which is herbal therapy, many researches have been conducted. Due to its anti-inflammatory effects, &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;(PM), an Indonesian indigenous herb, is considered to be the alternative therapy for UC.&lt;em&gt; Phaleria macrocarpa &lt;/em&gt;Leaves Ethanol Extract (PMLEE) is then used in this research to determine its effect on UC by using Ki-67 as a marker of proliferation. PMLEE was created from dry PM content undergoing maceration. The animals were classified into six categories: normal, positive control, negative control and PMLEE group (100, 200, 300 mg/kgBW). PMLEE was then injected for 7 consecutive days into BALB/c mice that were caused by dextran sodium sulphate (DSS). DSS is used for modeling UC in the colon tissue of mice. All mice were terminated and then stained with anti-Ki-67 after their colons were extracted. Subsequently, the stained parts were analyzed with ImageJ based on the color intensity produced by the results of H-score. Based on H-score, PMLEE 300mg and 200mg has significantly decreased the expression of Ki-67 compare to the negative control (p=0.001 and p=0.01). PMLEE also has a tendency to be dose dependent based on the significant difference from PMLEE 300mg and 100mg (p=0.002). It then concludes that PMLEE is related to Ki-67 expression in cells, as it was inversely proportional in this analysis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">443</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1,&lt;/sup&gt;*, Elvan Wiyarta&lt;sup&gt;2&lt;/sup&gt;, Ari Estuningtyas&lt;sup&gt;3&lt;/sup&gt;, Nurhuda Sahar&lt;sup&gt;4&lt;/sup&gt;, Yurnadi Hanafi Midoen&lt;sup&gt;4&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;5&lt;/sup&gt;, Alfred Pakpahan&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Jakarta, INDONESIA. 6Department of Oral Biology, Faculty of Dentistry, Universitas Trisakti, Jl. Kyai Tapa Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Elvan Wiyarta</style></author><author><style face="normal" font="default" size="100%">Ari Estuningtyas</style></author><author><style face="normal" font="default" size="100%">Nurhuda Sahar</style></author><author><style face="normal" font="default" size="100%">Yurnadi Hanafi Midoen</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential of Phaleria macrocarpa Leaves Ethanol Extract to Upregulate the Expression of Caspase-3 in Mouse Distal Colon after Dextran Sodium Sulphate Induction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahkota Dewa</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcerative colitis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">23-29</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained importance over the past few decades. A lot of research has been done to find effective treatments for UC, one of which is herbal medicine. &lt;em&gt;Phaleria macrocarpa&lt;/em&gt; (PM), an Indonesian native plant, is thought to be an alternative therapy for UC because of its anti-inflammatory properties. Therefore, in this research, &lt;em&gt;Phaleria macrocarpa&lt;/em&gt; Leaves Ethanol Extract (&lt;em&gt;PM&lt;/em&gt;LEE) is used to assess its effect on UC by using Caspase-3 as apoptosis marker. PMLEE was made from dried material of PM that undergo maceration. Animals were separated into six groups: normal, negative control, positive control, and PMLEE groups (100, 200, 300 mg/kgBW). PMLEE was then injected to BALB/c mice that have been induced by dextran sodium sulphate (DSS) for 7 consecutive days. DSS is used to model UC in mice colon tissue. All animals were sacrificed and their colons were collected then stained with anti-Caspase-3. The stained sections were subsequently examined with ImageJ based on color intensity which generated H-Score as the results. Based on H-Score of each group, PMLEE 300mg has significantly upregulate the expression of Caspase-3 compare to the negative control (p=0.015). PMLEE also has a tendency to be dose dependent based on the significant difference between PMLEE doses. Therefore, it concludes that PMLEE is able to upregulate the expression of Caspase-3 in colon cells as in this study it was directly proportional. &lt;strong&gt;Key words:&lt;/strong&gt; Mahkota Dewa, Inflammation, Apoptosis, Ulcerative colitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">23</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Elvan Wiyarta&lt;sup&gt;2,&lt;/sup&gt;*, Ari Estuningtyas&lt;sup&gt;3&lt;/sup&gt;, Nurhuda Sahar&lt;sup&gt;4&lt;/sup&gt;, Yurnadi Hanafi Midoen&lt;sup&gt;4&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;5Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6 Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prasad Thakurdesai</style></author><author><style face="normal" font="default" size="100%">Pallavi Deshpande</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preclinical Safety Evaluation of Acute and Subacute Intranasal Administration of Polyphenols-based Cinnamon Bark Extract in Laboratory Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Intranasal toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Maximum tolerated dose</style></keyword><keyword><style  face="normal" font="default" size="100%">Noobserved- adverse-effect level.</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Standardized cinnamon bark</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1621-1631</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Polyphenols-based standardized cinnamon (Cinnamomum zeylanicum) bark extract (IND02) demonstrated efficacy against allergic rhinitis in animal models and human clinical study. &lt;strong&gt;Objectives:&lt;/strong&gt; To assess the acute and subacute intranasal toxicity of the IND02 nasal solution (IND02-NS). &lt;strong&gt;Methods:&lt;/strong&gt; Acute and 28-days subacute toxicity using the intranasal route of administration of IND02-NS was evaluated using Wistar rats as per Organisation for Economic Co-operation and Development guidelines. For acute intranasal toxicity study, a single dose of 100 μg/rat/day was administered in five male and female rats and observed for the incidence of mortality and signs of toxicity for 14 days. For a 28-days subacute intranasal toxicity study, doses of 20, 50, and 100 μg/rat/day were administered to a group of five male and female rats.&lt;strong&gt; Results: &lt;/strong&gt;The IND02-NS did not show mortality or treatment-related adverse signs during acute (limit dose of 100 μg/rat/day) and subacute intranasal (28-days repeated dose of 20, 50, and 100 μg/rat/day with 14 days of reversal period) administration. The IND02-NS showed a maximum tolerated dose greater than 100 μg/rat during the acute intranasal toxicity study. The no-observed adverse effect level of IND02-NS was 100 μg/rat/day in rats during the subacute intranasal toxicity study. &lt;strong&gt;Conclusion:&lt;/strong&gt; IND02-NS was found safe at 100 μg/rat/day during acute and subacute (28 days repeated dose) for nasal administration in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1621</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prasad Thakurdesai&lt;sup&gt;1&lt;/sup&gt;, Pallavi Deshpande&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Scientific Affairs, Indus Biotech Private Limited, Kondhwa, Pune, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amel CHOUABIA</style></author><author><style face="normal" font="default" size="100%">Samir DJEMLI</style></author><author><style face="normal" font="default" size="100%">Cherif ABDENNOUR</style></author><author><style face="normal" font="default" size="100%">Leila MALLEM</style></author><author><style face="normal" font="default" size="100%">Labiba KAHALERRAS</style></author><author><style face="normal" font="default" size="100%">Fatma Zohra ARKOUB</style></author><author><style face="normal" font="default" size="100%">Narimene BOUABDALLAH</style></author><author><style face="normal" font="default" size="100%">Abdelkrim TAHRAOUI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective effect of Salvia officinalis against cypermethrininduced reprotoxicity in male Wistar rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cypermethrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatozoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1413-1421</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Medicinal plants are a reservoir of biologically active compounds with therapeutic properties that, over time, have been used for the treatment of various diseases. This study aims to evaluate the protective effect of the aqueous extract of the leaves of&lt;em&gt; Salvia officinalis &lt;/em&gt;against cypermethrin-induced toxicity. &lt;strong&gt;Methods: &lt;/strong&gt;30 male rats weighing approximately 240 g were divided into equal six groups; the control group received tap water, the positive control received the aqueous extract of sage leaves (SLE) at a dose of (0.5g/kg bw), the groups treated with cypermethrin (Cyp1) at 8.33 mg/kg bw and (Cyp2) at 25 mg/kg bw, and the groups treated by cypermethrin combined with aqueous extract of sage SLE+Cyp1 (0.5g/kg bw+8.33 mg/kg bw) and SLE+Cyp2 (0.5g/kg bw+25 mg/kg bw) for four days/week. After 4 weeks of oral administration, epididymal seminal fluid was analyzed via the CASA system, in addition to the histological study testis and epididymis. &lt;strong&gt;Results: &lt;/strong&gt;The obtained results showed a decrease in the absolute weight of the reproductive organs, with a significant decrease in sperm concentration, motility and speed in the cypermethrin-treated group compared to the control. Histological study of the testes and epididymis indicates an alteration in the stages of spermatogenesis in groups Cyp1 and Cyp2 compared to the control. However, the above-mentioned parameters were maintained almost normal in the groups that received the aqueous extract of sage with both doses of cypermethrin. &lt;strong&gt;Conclusion:&lt;/strong&gt; it can be demonstrated that SLE has been shown to protect rats from cypermethrin-induced reprotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1413</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amel CHOUABIA&lt;sup&gt;1&lt;/sup&gt;, Samir DJEMLI&lt;sup&gt;2&lt;/sup&gt;,*, Cherif ABDENNOUR&lt;sup&gt;1&lt;/sup&gt;, Leila MALLEM&lt;sup&gt;1&lt;/sup&gt;, Labiba KAHALERRAS&lt;sup&gt;1&lt;/sup&gt;, Fatma Zohra ARKOUB&lt;sup&gt;1&lt;/sup&gt;, Narimene BOUABDALLAH&lt;sup&gt;1&lt;/sup&gt;, Abdelkrim TAHRAOUI&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Sciences, Animal Ecophysiology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Sciences, Applied Neuroendocrinology Laboratory, Department of Biology, Badji Mokhtar University, Annaba, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Qualitative and Quantitative Analysis of 70% Ethanol Extract from Ruta angustifolia for Developing Anti-Hepatitis C Agents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatitis C Virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Infectious disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Ruta angustifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Rutin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">682-687</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Medicinal plants are potential sources for drug candidates. It possesses with various metabolites which have many pharmacology effects. &lt;em&gt;Ruta angustifolia&lt;/em&gt; is one of medicinal plants that has been used traditionally for liver disease. Previous study it has been demonstrated to inhibit hepatitis C virus under in vitro cell culture. It decreased protein NS3 level and gave synergistic effect in combination with simeprevir and telaprevir. This plant provides a prospective candidate to develop as anti-HCV Objective: This study evaluates the phytochemistry screening for qualitative assay and determine the concentration of rutin as marker compound for developing &lt;em&gt;R. angustifolia&lt;/em&gt; extract as anti-HCV agent.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;R. angustifolia&lt;/em&gt; leaves were extracted with 70% of ethanol. Extract and rutin were analysis their anti-HCV activity by in vitro culture cells of Huh7it. The concentration of rutin was determine by TLC densitometry. &lt;strong&gt;Results:&lt;/strong&gt; The 70% ethanol extract of &lt;em&gt;R. angustifolia &lt;/em&gt;dan rutin exhibit anti-HCV activities with IC&lt;sub&gt;50&lt;/sub&gt; value of 2.9 ± 0.8 μg/ml and 28.1 ± 5.6 μg/ml, respectively. Screening phytochemistry demonstrated to contain flavonoid, terpenoid, alkaloid and polyphenols. TLC densitometry analysis yield the concentration of rutin in extract 0.06 %. &lt;strong&gt;Conclusion:&lt;/strong&gt; Extract of 70% ethanol of &lt;em&gt;R. angustifolia &lt;/em&gt;has a potential anti-HCV activity. Extract of &lt;em&gt;R. angustifolia&lt;/em&gt; may provide a good candidate for developing anti-HCV agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Tutik Sri Wahyuni&lt;sup&gt;1,2,&lt;/sup&gt;*, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;1,2&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herin Setianingsih</style></author><author><style face="normal" font="default" size="100%">Satria Erda Wisnumarta</style></author><author><style face="normal" font="default" size="100%">Sareh Arjono Tjandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Repairing of Renal Tubules in Diabetic Rats (Rattus norvegicus) Diabetes After Administration of Golden Sea Cucumber (Stichopus hermanii)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetic rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Stichopus hermanii</style></keyword><keyword><style  face="normal" font="default" size="100%">Tubular injury</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">958-964</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to analyze the improvement of the histopathological picture of renal tubules in diabetic rats after being given golden sea cucumber extract (&lt;em&gt;Stichopus hermanii&lt;/em&gt;). This research uses experimental design laboratories with a post-test only control group design method. The sampling used simple random sampling with 25 white rats divided into five groups, namely groups that were given standard feed without STZ-induced, STZ-induced group, STZ-induced group and given golden sea cucumber extract at a dose of 4.25 mg/kg BW for 21 days, STZinduced group and given golden sea cucumber extract at a dose of 8.5 mg/kg BW for 21 days, and STZ-induced group and given gold sea cucumber extract at a dose of 12.75 mg/kg BW for 21 days. The data on the observation of each group's kidney histopathology was carried out at the end of the session. The results of the analysis using the Kruskal-Wallis Test showed significant results, the Mann-Whitney Test showed significant differences between the STZinduced group and the golden sea cucumber extract (&lt;em&gt;Stichopus hermanii&lt;/em&gt;) dose of 12.75 mg/kg BW (x=7.4 mg/dl) decreased significantly (p=0.001) compared to the STZ-only-induced group (x=12.6 mg/dl). Administration of golden sea cucumber extract (&lt;em&gt;Stichopus hermanii&lt;/em&gt;) at a dose of 12.75 mg/kg BW of rats for 21 days lowered the degree of tubular damage to the kidney rectus of white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) male streptozotocin-induced strains.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">958</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herin Setianingsih*, Satria Erda Wisnumarta, Sareh Arjono Tjandra&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gagan Tiwana</style></author><author><style face="normal" font="default" size="100%">Jiahe Fua</style></author><author><style face="normal" font="default" size="100%">Lanping Lu</style></author><author><style face="normal" font="default" size="100%">Matthew J Cheesman</style></author><author><style face="normal" font="default" size="100%">IE.Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review of the Traditional Uses, Medicinal Properties and Phytochemistry of Centaurea benedicta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Blessed thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">St Benedict’s thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">798-812</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Centaurea benedicta&lt;/em&gt; L. is an annual herbaceous plant which belongs to the Asteraceae family. It is native to the Mediterranean region and western Asia and is commonly known as blessed thistle, holy thistle, St Benedict’s thistle or spotted thistle. Traditionally, it has been used to treat bubonic plague and possesses diuretic, galactagogue, liver-strengthening and wound healing properties. Recent research studies have investigated its anticancer, antiinflammatory, antioxidant and other therapeutic properties. Several studies have also reported its antimicrobial activity against a range of bacterial pathogens. However, most of these studies were preliminary and only tested relatively high concentrations of the extracts. Additionally, most studies screened a limited number of pathogens. Cnicin is the main chemical compound present in &lt;em&gt;C. benedicta &lt;/em&gt;and it has been widely investigated. However, few other compounds from this plant have been identified and/or investigated, and further phytochemical studies are warranted. Interestingly, pure cnicin has good anticancer activity, whilst the crude extracts lack cytotoxic properties. Phytochemical analyses of&lt;em&gt; C. benedicta &lt;/em&gt;extracts reveal the presence of multiple flavonoids, tannins, terpenoids and lactones, although few specific phytochemicals within these phytochemical classes have been identified. A limited number of research studies have determined the toxicity profile of &lt;em&gt;C. benedicta &lt;/em&gt;in order to evaluate its safety for human use. Substantially more detailed studies are required to rigorously investigate the therapeutic properties and phytochemistry of &lt;em&gt;C. benedicta&lt;/em&gt;, which may ultimately lead to the development of new plant-based therapeutic medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gagan Tiwana&lt;sup&gt;1,2&lt;/sup&gt;, Jiahe Fua&lt;sup&gt;2&lt;/sup&gt;, Lanping Lu&lt;sup&gt;2&lt;/sup&gt;, Matthew J. Cheesman&lt;sup&gt;1,3&lt;/sup&gt;, I.E.Cock&lt;sup&gt;2,4,&lt;/sup&gt;*&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Menzies Health Institute Queensland, Quality Use of Medicines Network, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Omar Elhamdaoui</style></author><author><style face="normal" font="default" size="100%">Zineb ibn lahmar Andaloussi</style></author><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Khalid Taghzouti</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Diuretic Activity of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. In Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Corrigiola telephiifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Diuretic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diuretic plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaliuresis</style></keyword><keyword><style  face="normal" font="default" size="100%">Urine electrolytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1552-1558</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study was undertaken to justify and validate a very frequent traditional use of a very well-known and widely used plant by a large part of the Moroccan population. It’s about &lt;em&gt;Corrigiola telephiifolia&lt;/em&gt;, and the activity in question is the diuretic activity.&lt;strong&gt; Methods: &lt;/strong&gt;The aqueous ethanol root extract of&lt;em&gt; CMethods:orrigiola telephiifolia&lt;/em&gt; (200 mg/kg, 400 mg/kg, and 700 mg/kg) was orally administered to rats. The urinary excretion rate and pH, and electrolyte excretion were measured in the urine of saline-loaded rats. Negative control group received only an equivalent volume of distilled water, while the positive control groups received the diuretic drugs hydrochlorothiazide at dose 10 mg/kg. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that hydrochlorothiazide induced significant diuresis and electrolytes excretion at 1, 6 and 24 h after the treatment. Both the higher doses of the extract produced a significant increase in urine volume than the control from the first hour until the end of observation. However, the lowest dose increased significantly only at 24 h after the treatment. With regard to the electrolyte excretion, the tested doses of CTRE which have shown a significant increase in Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt; and Cl&lt;sup&gt;-&lt;/sup&gt;excretion in comparison to normal control rats, are 400 and 700 mg/kg bw. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings collectively indicate that the extracts of&lt;em&gt; C. telephiifolia&lt;/em&gt; have a potential to induce diuresis markedly, and providing evidence, for its traditional use.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1552</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Imane Zakariya&lt;sup&gt;1,&lt;/sup&gt;* , Omar Elhamdaoui&lt;sup&gt;1&lt;/sup&gt;, Zineb ibn lahmar Andaloussi&lt;sup&gt;2&lt;/sup&gt;, Abdelhak Chergui&lt;sup&gt;1&lt;/sup&gt;, Al amine Ajlal&lt;sup&gt;1&lt;/sup&gt;, Khalid Taghzouti&lt;sup&gt;2&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of pharmacognosy, faculty of medicine and pharmacy, University Mohammed V, BP 6203, RABAT, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, faculty of science, University Mohammed V, BP: 1014, Rabat- MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwi Susiloningrum</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Myrna Adianti</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Mulyadi Tanjung</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-HCV</style></keyword><keyword><style  face="normal" font="default" size="100%">Melicope latifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">N-methylflindersine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">535-540 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Hepatitis C Virus (HCV) is a major health problem, which infects approximately 170 million people among worldwide population. Moreover, there is no vaccine available to prevent HCV infection and the current anti-HCV drugs have not covered all the various genotypes and subtypes. Meanwhile, medicinal plants have been widely used to treat a variety of infectious disease. Our previous study reported that ethanol extract of &lt;em&gt;Melicope latifolia &lt;/em&gt;has been shown to exert anti-HCV activity towards a number of different virus genotypes with mainly inhibition mechanism at the entry step. Further separation was needed to purify and identify the active anti-HCV constituent using bioactivity-guided isolation method.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; Anti-HCV assay was performed using hepatocyte cell line (Huh7it) and HCV genotype 2a (JFH1). The purification of &lt;em&gt;M. latifolia &lt;/em&gt;ethanol extract (B1F) was done by liquid-liquid fractionation, vacuum liquid chromatography (VLC), and high-performance liquid chromatography (HPLC). The active fraction was further identified by thin layer chromatography (TLC) and the major constituent was determined by nuclear magnetic resonance (NMR) spectra data analysis. &lt;strong&gt;Results: &lt;/strong&gt;The fractionation of &lt;em&gt;M. latifolia&lt;/em&gt; leaves ethanol extract resulted an alkaloid fraction (B1F D2H.3) containing a major constituent N-methylflindersine. This alkaloid fraction was active to reduce HCV JFH1 with an inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value of 6.21 µg/mL, a cytotoxicity concentration (CC&lt;sub&gt;50&lt;/sub&gt;) value of 82.64 µg/mL, and a selectivity index value of 13.31. &lt;strong&gt;Conclusion: &lt;/strong&gt;An alkaloid fraction of &lt;em&gt;M. latifolia&lt;/em&gt; (B1F D2H.3) was known to have major compound named N-methylflindersine. This alkaloid fraction exhibited strong anti-HCV against JFH1 &lt;em&gt;in vitro&lt;/em&gt;. The results indicated that this alkaloid fraction may a good candidate for anti-HCV agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">535</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwi Susiloningrum&lt;sup&gt;1&lt;/sup&gt;, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Myrna Adianti&lt;sup&gt;2,3&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Tutik Sri Wahyuni&lt;sup&gt;2,4&lt;/sup&gt;, Mulyadi Tanjung&lt;sup&gt;2,5&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;2,4&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;2,4&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Traditional Medicine Study Program, Faculty of Vocational, Universitas Airlangga, Surabaya 60286, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Abdur Rauf</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author><author><style face="normal" font="default" size="100%">Victor Fernández-Guzmán</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticarcinogenic agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Preventive medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">562-568 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To determine the ameliorative effect of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. &lt;strong&gt;Methods: &lt;/strong&gt;36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. &lt;strong&gt;Results: &lt;/strong&gt;Hematology showed that the triglyceride level was significantly lowered (P&amp;lt; 0.01) and high-density lipoprotein (HDL) level was significantly increased (P &amp;lt;0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P &amp;lt;0.01) and malondialdehyde level (P&amp;lt;0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P&amp;lt;0.01). &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt;&lt;strong&gt; &lt;/strong&gt;Chuquiraga spinosa&lt;/em&gt; showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;2,&lt;/sup&gt;*, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Abdur Rauf&lt;sup&gt;4&lt;/sup&gt;, Renán Hañari-Quispe&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa-Salvador&lt;sup&gt;6&lt;/sup&gt;, Victor Fernández-Guzmán&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Human Medicine, School of Pharmacy and Biochemistry, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, University of Swabi, Swabi-23430, KPK, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinic Pathology, Faculty of Veterinary medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Graduate School of Business, ESAN University, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Rista Putrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anticancer Activity of Ruellia britoniana Flower on Cervical HeLa Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Ruellia brittoniana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">29-34</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cervical cancer ranks 4&lt;sup&gt;th&lt;/sup&gt; in terms of the mortality rates and incidence of all cancers in women (GLOBOCAN 2018). In last decade, there is a significance progress in cancer therapy followed by an increase in the cost of cancer treatment. Therefore, it is necessary to have therapeutic innovations that are expected to reduce the cost of cervical cancer therapy. One therapeutic innovation that is currently being intensively carried out is herbal medicine. Some researchers have found that some plant extracts have anti-cancer properties that can be an alternative treatment for cancer, such as some plants with the genus &lt;em&gt;Ruellia&lt;/em&gt;, such as &lt;em&gt;Ruellia tuberosa &lt;/em&gt;and &lt;em&gt;Ruellia squarrosa&lt;/em&gt;. However, research on the anticancer activity of the species of &lt;em&gt;Ruellia brittoniana&lt;/em&gt;, especially the flowers, is still limited. &lt;strong&gt;Objective: &lt;/strong&gt;Aim of this study is to examine anti-cervical cancer activity of &lt;em&gt;R. brittoniana&lt;/em&gt; flower. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;R.brittoniana&lt;/em&gt; flowers were obtained from Depok, West Java, Indonesia. The flowers are extracted gradually with n-hexane, ethyl acetate, and ethanol solvents. The extracts were evaluated for anticancer activity by MTT method.&lt;strong&gt; Results: &lt;/strong&gt;IC&lt;sub&gt;50&lt;/sub&gt; values for ethanol extract, ethyl acetate extract and n-hexane extract of &lt;em&gt;R. brittoniana&lt;/em&gt; flowers are 116.55 ppm, 52.62 ppm, and 123.09 ppm, respectively, which indicating that ethanol extract has moderate anticancer activity, while ethyl acetate and n-hexane extract of &lt;em&gt;R. brittoniana&amp;nbsp;&lt;/em&gt;flowers have weak anticancer activity.&lt;strong&gt; Conclusion:&lt;/strong&gt; Ethanol, ethyl acetate, and n-hexane extract of &lt;em&gt;R.brittoniana&lt;/em&gt; flowers have a potential to become natural anti-cervical cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">29</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nadzila Anindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Rista Putrianingsih&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fania El Ridhasya</style></author><author><style face="normal" font="default" size="100%">Novia Rahim</style></author><author><style face="normal" font="default" size="100%">Muhammad Almurdani</style></author><author><style face="normal" font="default" size="100%">Rudi Hendra</style></author><author><style face="normal" font="default" size="100%">Hilwan Yuda Teruna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Helminthostacys zeylanica</style></keyword><keyword><style  face="normal" font="default" size="100%">Ophioglossaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">223-226</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The roots of tunjuk langit (&lt;em&gt;Helminthostacshys zeylanica&lt;/em&gt;) have been used traditionally in some villages in Indonesia, particularly in Riau Province. &lt;strong&gt;Objective:&lt;/strong&gt; In this study we reported two flavonoids and their antidiabetic activity. &lt;strong&gt;Material and methods: &lt;/strong&gt;Isolation of the metabolites was based on polarity fractionation method. Purification processes were conducted by vacuum liquid chromatography (VLC). Chemical structures were elucidated based on spectroscopy characteristics, including FTIR and 1D/2D NMR. &lt;strong&gt;Results: &lt;/strong&gt;The isolated compounds were identified as ugonin J and K. The antidiabetic activity was measured by &lt;em&gt;α&lt;/em&gt;-glucosidase inhibitor assay. The antidiabetic activity of ugonin J was found at IC&lt;sub&gt;50&lt;/sub&gt; 273,13±0,402 ppm and Ugonin K was found at IC&lt;sub&gt;50 &lt;/sub&gt;138,21±0,263 ppm (moderately active). &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore this plant can be used traditionally as antidiabetic medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, Hilwan Yuda Teruna* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Pekanbaru 28293, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agriana Rosmalina Hidayati</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Hilkatul Ilmi</style></author><author><style face="normal" font="default" size="100%">Mulyadi Tanjung</style></author><author><style face="normal" font="default" size="100%">Tri Widiandani</style></author><author><style face="normal" font="default" size="100%">Siswandono</style></author><author><style face="normal" font="default" size="100%">Din Syafruddin</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial Activity of Flavonoid Compound Isolated from Leaves of Artocarpus altilis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artocarpus altilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cysteine protease inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Dihydrochalcones</style></keyword><keyword><style  face="normal" font="default" size="100%">P. falciparum 3D7</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">835-842</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Artocarpus altilis&lt;/em&gt; leaves extract has previously been reported as a potential antimalarial drug. Inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) against &lt;em&gt;P. falciparum&lt;/em&gt; and effective dose values (ED&lt;sub&gt;50&lt;/sub&gt;) against P. berghei have been reported at 1.32 μg/ml and 0.82 mg/kg, respectively. The aim of this study is to identify the active compound from the ethanol extract of &lt;em&gt;A. Altilis&lt;/em&gt; leaves against &lt;em&gt;P. falciparum.&lt;/em&gt; Materials and Methods: The isolation of the active compound from the ethanol extract of&lt;em&gt; A. altilis &lt;/em&gt;were conducted using chromatography methods, and the chemical structure of the isolated compounds was determined based on NMR and MS spectra data. Antimalarial assay was determined using microscopic method against &lt;em&gt;P. falciparum&lt;/em&gt; 3D7 and molecular docking studies was performed using Molegro Virtual Docker version 5.5 program. &lt;strong&gt;Results:&lt;/strong&gt; A flavonoid compound, class of dihydrochalcone was finally isolated from &lt;em&gt;A. altilis &lt;/em&gt;and identified as&lt;em&gt; 1-(2,4-dihydroxy phenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3- pentenyl)-2H-1-benzopyran-5-yl]-1-propanone&lt;/em&gt; (Compound-1). Antimalarial activity test revealed that the compound strongly inhibited &lt;em&gt;P. falciparum&lt;/em&gt; growth, with IC&lt;sub&gt;50&lt;/sub&gt; value of 1.05 μM. An in silico study to determine the mechanism of action of the compound revealed the existence a 3.BPF receptor that possesses a cysteine protease inhibitor of falcipain-2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compound-1 were isolated from the leaves of &lt;em&gt;A. Altilis&lt;/em&gt; is a good candidate of new source in the development of antimalarial drugs. An animal study using this compound is recommended before a clinical trial.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">835</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agriana Rosmalina Hidayati&lt;sup&gt;1,2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;3,4,&lt;/sup&gt;*, Hilkatul Ilmi&lt;sup&gt;4&lt;/sup&gt;, Mulyadi Tanjung&lt;sup&gt;4,5&lt;/sup&gt;, Tri Widiandani&lt;sup&gt;6&lt;/sup&gt;, Siswandono&lt;sup&gt;6&lt;/sup&gt;, Din Syafruddin&lt;sup&gt;7,8&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;3,4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post Graduate Student of Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Mataram, Mataram 83125, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60826, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Departement of Pharmaceutical Chemistry Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Eijkman Institute for Molecular Biology, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raceline Gounoue Kamkumo</style></author><author><style face="normal" font="default" size="100%">Abel Narcisse Messi Betene</style></author><author><style face="normal" font="default" size="100%">Patrick Valere Tsouh Fokou</style></author><author><style face="normal" font="default" size="100%">Jean Hubert Donfack</style></author><author><style face="normal" font="default" size="100%">Marius Jaurès Tsakem Nangap</style></author><author><style face="normal" font="default" size="100%">Albertine Ngako</style></author><author><style face="normal" font="default" size="100%">Roberto Fokou</style></author><author><style face="normal" font="default" size="100%">Mariscal Brice Tchatat Tali</style></author><author><style face="normal" font="default" size="100%">Florence Ngueguim Tsofack</style></author><author><style face="normal" font="default" size="100%">Théophile Dimo</style></author><author><style face="normal" font="default" size="100%">Fabrice Fekam Boyom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial Effects of the Aqueous Extract of Entandrophragma angolense Bark on Plasmodium berghei Infection in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiplasmodial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">E. angolense</style></keyword><keyword><style  face="normal" font="default" size="100%">Malaria infection</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">P. berghei</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">687-698</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Research for new antimalarial drugs remains a permanent quest for the control of malaria. &lt;strong&gt;Objective:&lt;/strong&gt; The present study investigates the effects of the aqueous extract of &lt;em&gt;Entandrophragma angolense&lt;/em&gt; bark on&lt;em&gt; P. berghei-&lt;/em&gt;induced malaria in mice. &lt;strong&gt;Methods: &lt;/strong&gt;Eight weeks old mice, were intraperitoneally infested with 200 μl of blood, containing 1x10&lt;sup&gt;6&lt;/sup&gt; &lt;em&gt;P. berghei&lt;/em&gt;-infected-erythrocytes. Parasitaemia was determined using a 10% giemsa stained blood smear read under optical microscope (x100). The infected animals were randomized into 5 groups of 10 animals each and daily treated for 5 days with the plant extract at 125, 250 and 500 mg/kg. The normal control and malaria control received water while the chloroquine control was treated with 10 mg/kg of chloroquine. Body weight, parasitaemia and survival time were monitored daily during treatment and follow up periods. Five animals from each group were sacrificed under anaesthesia at the end of treatment (d8) and after the follow up period (d28). Venous blood was used for haematological and biochemical tests. Organs (liver, kidneys and spleen) were also collected for biochemical and histological analyses. &lt;strong&gt;Results: &lt;/strong&gt;Administration of the aqueous extract of &lt;em&gt;E. angolense &lt;/em&gt;bark to infected mice significantly inhibited parasite development (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.001) with ED&lt;sub&gt;50&lt;/sub&gt; estimated at 25.32 mg/kg. The extract prevented animal from death, body weight loss, anaemia, leucocytosis, high transaminases (ALT and AST), high bilirubin, creatinine and MDA levels, oxidative stress and anatomical alteration in organs as compared to the malaria control.&lt;strong&gt; Conclusion:&lt;/strong&gt; The &lt;em&gt;E. angolense &lt;/em&gt;bark possesses antimalarial properties, supporting its use in traditional medicine to treat malaria.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raceline Gounoue Kamkumo&lt;sup&gt;1,2,&lt;/sup&gt;*, Abel Narcisse Messi Betene&lt;sup&gt;1,2&lt;/sup&gt;, Patrick Valère Tsouh Fokou&lt;sup&gt;2,3&lt;/sup&gt;, Jean Hubert Donfack&lt;sup&gt;4&lt;/sup&gt;, Marius Jaurès Tsakem Nangap&lt;sup&gt;1,2&lt;/sup&gt;, Albertine Ngako&lt;sup&gt;1,2&lt;/sup&gt;, Roberto Fokou&lt;sup&gt;1,2&lt;/sup&gt;, Mariscal Brice Tchatat Tali&lt;sup&gt;2&lt;/sup&gt;, Florence Ngueguim Tsofack&lt;sup&gt;1&lt;/sup&gt;, Théophile Dimo&lt;sup&gt;1&lt;/sup&gt;, Fabrice Fekam Boyom&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812, Yaounde, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Science, University of Bamenda, P.O. Box 39, Bamenda, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Sciences, University of Dschang, P.O. Box 67, Dschang, CAMEROON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Malatee Tayeh</style></author><author><style face="normal" font="default" size="100%">Poonsit Hiransai</style></author><author><style face="normal" font="default" size="100%">Hathaichanok Kommen</style></author><author><style face="normal" font="default" size="100%">Ramida Watanapokasin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-migration and Anti-invasion Abilities of Methanolic Leaves Extract of Clerodendrum Inerme on Lung Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-invasion</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-migration</style></keyword><keyword><style  face="normal" font="default" size="100%">Clerodendrum inerme</style></keyword><keyword><style  face="normal" font="default" size="100%">Human lung adenocarcinoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1024-1031</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Clerodendrum inerme &lt;/em&gt;is a folk medicinal plant used in the treatment of various illnesses such as a cough, scrofulous infection, venereal infection, skin diseases and tumors. It exhibited many pharmacological effects including hepatoprotective, anti-inflammatory, antibacterial, anti-oxidant and anticancer properties. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study was to investigate the influence of methanolic extract of&lt;em&gt; C. inerme&lt;/em&gt; leaves on migration, invasion and adhesion activities on human lung adenocarcinoma. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Cytotoxicity, cell motility, migration, invasion and adhesion abilities were detected by MTT, wound healing, trans-well mobilization, modified Boyden chamber and cell adhesion assay, respectively. &lt;strong&gt;Results: &lt;/strong&gt;The results demonstrated that up to 400 μg/mL methanolic leaves extract has low toxicity on A549 cells showing more than 50% cell viability. At non-cytotoxic and sub-toxic doses (200 and 400 μg/mL) of methanolic leave extract significantly suppressed cell motility, migration, invasion and cell adhesion compared with the untreated control. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggested that methanolic leaves extract of &lt;em&gt;C. inerme &lt;/em&gt;inhibited migration, invasion and adhesion of A549 cells. These findings showed new therapeutic potential for &lt;em&gt;C. inerme&lt;/em&gt; in anti-metastatic therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1024</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Malatee Tayeh&lt;sup&gt;1,&lt;/sup&gt;*, Poonsit Hiransai&lt;sup&gt;1&lt;/sup&gt;, Hathaichanok Kommen&lt;sup&gt;2&lt;/sup&gt;, Ramida Watanapokasin&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Sciences, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Srinkharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Almurdani</style></author><author><style face="normal" font="default" size="100%">Adel Zamri</style></author><author><style face="normal" font="default" size="100%">Titania T Nugroho</style></author><author><style face="normal" font="default" size="100%">Jasril Karim</style></author><author><style face="normal" font="default" size="100%">Yum Eryanti</style></author><author><style face="normal" font="default" size="100%">Rudi Hendra</style></author><author><style face="normal" font="default" size="100%">Hilwan Yuda Teruna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Antidiabetic Activities of Mempening (Lithocarpus bancanus) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lithocarpus bancanus</style></keyword><keyword><style  face="normal" font="default" size="100%">Talang Mamak Tribe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">328-334</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Lithocarpus bancanus &lt;/em&gt;or commonly called as mempening in Talang Mamak Tribe, Indonesia is a plant that is used as a traditional medicine.&lt;strong&gt; Objective: &lt;/strong&gt;This study aim to evaluated antioxidant and antidiabetic activities of &lt;em&gt;L. bancanus&lt;/em&gt; leaves extract. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The methanol extract was obtained by maceration of the leaves. The n-hexane, dichloromethane and ethyl acetate fractions were prepared by successive partition process of the methanol extract. Antioxidant activities were evaluated by various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), CUPRAC (&lt;em&gt;cupric reducing antioxidant capacity&lt;/em&gt;), and ABTS (&lt;em&gt;2,2’-azonobis 3-ethylbenzothiazoline-6-sulfonic acid&lt;/em&gt;) method. Total phenolics were estimated based on the Folin–Ciocalteu method, while, aluminum chloride methods were employed to estimate total flavonoids. Antidiabetic activies was determined by inhibiting the activity of α-glucosidase method. Results: antioxidant activity assay against DPPH radical as well as the total phenolic and flavonoid content of &lt;em&gt;L. bancanus&lt;/em&gt; leaves showed that the methanol extract possessed IC&lt;sub&gt;50&lt;/sub&gt; value of 39.469 ± 0.273 μg/mL with total phenol and flavonoid were 11.426 ± 0.432 mg GAE/g dry weight sample and 15.423 ± 0.213 mg QE/g respectively. The FRAP, CUPRAC and ABTS values of methanol extract were 3494.302 ±0.456, 26665.501 ± 5.940 and 2857.977 ± 0.715 μM TE/g dry weight sample respectively. Antidiabetic activity of methanol extract with IC&lt;sub&gt;50&lt;/sub&gt; value of 30.565 ± 0.331 μg/mL. Conclusion: It could be concluded that leaves of &lt;em&gt;L. bancanus&lt;/em&gt; have antioxidant and antidiabetic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">328</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Almurdani&lt;sup&gt;1&lt;/sup&gt;, Adel Zamri&lt;sup&gt;1&lt;/sup&gt;, Titania T. Nugroho&lt;sup&gt;1&lt;/sup&gt;, Jasril Karim&lt;sup&gt;1&lt;/sup&gt;, Yum Eryanti&lt;sup&gt;1&lt;/sup&gt;, Rudi Hendra&lt;sup&gt;1&lt;/sup&gt;, Hilwan Yuda Teruna&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Pekanbaru 28293, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Howaida Ibrahim Abd-Alla</style></author><author><style face="normal" font="default" size="100%">Magda Tohamy Ibrahim</style></author><author><style face="normal" font="default" size="100%">Hanan Anwar Aly Taie</style></author><author><style face="normal" font="default" size="100%">Marwa Abas Hasan</style></author><author><style face="normal" font="default" size="100%">Nagwa M M Shalaby</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiradical effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Immune</style></keyword><keyword><style  face="normal" font="default" size="100%">Isoflavones</style></keyword><keyword><style  face="normal" font="default" size="100%">Paramyxovirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Pigeons</style></keyword><keyword><style  face="normal" font="default" size="100%">Sophora secundiflora</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1276-1288</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present work investigated the effect of oral administration of hydroalcoholic (70% aqueous ethanol) extract (TeE) of &lt;em&gt;Sophora secundiflora&lt;/em&gt; leaves and its organic fractions n-hexane (HeE), ethyl acetate (EaE) and n-butanol (BuE) and major isolated methoxyisoflavones &lt;strong&gt;1&lt;/strong&gt; and&lt;strong&gt; 2,&lt;/strong&gt; on the cellular and humoral immune responses to live attenuated avian paramyxovirus-1 (APMV-1) vaccines in pigeons. &lt;strong&gt;Methods:&lt;/strong&gt; The structures of six isolated compounds were elucidated on the basis of chromatographic, chemical, and spectroscopic methods. The samples antioxidative and radical scavenging capabilities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation and ferric reducing power were determined. Total phenolic, tannin and flavonoid contents of EaE extract were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; Six compounds were isolated. Three were the methoxyisoflavones5- 7-dihydroxy-4′-methoxyisoflavone &lt;strong&gt;(1),&lt;/strong&gt; 7-hydroxy-4′methoxyisoflavone&lt;strong&gt; (2),&lt;/strong&gt; 5,4'-dihydroxy-7- methoxy-isoflavone&lt;strong&gt; (3),&lt;/strong&gt; along with isorhamnetin &lt;strong&gt;(4)&lt;/strong&gt; and two quercetin derivatives quercetin 3-glucoside &lt;strong&gt;(5) &lt;/strong&gt;and quercetin 3-rutinoside &lt;strong&gt;(6) &lt;/strong&gt;were isolated. The hydroalcoholic extract, fractions and 4'-methoxyisoflavones showed radical scavenging effect in the order of EaE &amp;gt; TeE &amp;gt; BuE &amp;gt;compound&lt;strong&gt; 1&amp;gt;&lt;/strong&gt;compound&lt;strong&gt; 2&amp;gt;&lt;/strong&gt; HeE. Stimulation of both sero-responses was observed, especially this of EaE. The results showed an increase of macrophage cells, lymphocyte and antibody titers in blood. &lt;strong&gt;Conclusion:&lt;/strong&gt; The presence of 5-hydroxyl group at A-ring may be important to show the immunostimulant and antioxidant activity of compound &lt;strong&gt;1&lt;/strong&gt;vs compound &lt;strong&gt;2&lt;/strong&gt;. The present results showed the potential abilities of EaE as antioxidant and immunomodulator agent and these would impart healthy economic benefits in vaccinated birds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Howaida Ibrahim Abd-Alla&lt;sup&gt;1,&lt;/sup&gt;*, Magda Tohamy Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Hanan Anwar Aly Taie&lt;sup&gt;3&lt;/sup&gt;, Marwa Abas Hasan&lt;sup&gt;4&lt;/sup&gt;, Nagwa M. M. Shalaby&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry of Natural Compounds, National Research Centre, El-Bohouth Street, National Research Centre, Giza-Dokki 12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, Sinai University, Kantara Branch, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Plant Biochemistry Department, National Research Centre, Giza-Dokki 12622, EGYPT. 4Bab El-Shaariya University Hospital, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Moragot Chatatikun</style></author><author><style face="normal" font="default" size="100%">Pitaksit Supjaroen</style></author><author><style face="normal" font="default" size="100%">Patcharaporn Promlat</style></author><author><style face="normal" font="default" size="100%">Chantanapa Chantarangkul</style></author><author><style face="normal" font="default" size="100%">Sutida Waranuntakul</style></author><author><style face="normal" font="default" size="100%">Jiraphat Nawarat</style></author><author><style face="normal" font="default" size="100%">Jitbanjong Tangpong</style></author><author><style face="normal" font="default" size="100%">Jitbanjong Tangpong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Tyrosinase Inhibitory Properties of an Aqueous Extract of Garcinia atroviridis Griff. ex. T. Anderson Fruit Pericarps</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">B16F10 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia atroviridis</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase activity</style></keyword><keyword><style  face="normal" font="default" size="100%">α-MSH</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">71-78</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Ultraviolet radiation (UVR) is the major cause for hyperpigmentation, and to prevent this natural products are increasingly being explored as potential skin whitening agents. The aim of this study was to determine the total phenolic and flavonoid content, free radical scavenging activity, anti-tyrosinase activity and the inhibition of melanin content in α-melanocyte stimulating hormone-induced B16F10 melanoma cells of an aqueous extract of&lt;em&gt; Garcinia atroviridis&lt;/em&gt; Griff. ex. T. Anderson fruit pericarps. Methods: The aqueous extract was prepared by extraction with distilled water at 105oC for 60 min. Total phenolic and flavonoid content were determined using the Folin-Ciocalteau and aluminium chloride methods, respectively. Scavenging activity was assessed using 2,2-Diphennyl-1-picrylhydrazyl (DPPH) and 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS). Tyrosinase activity and melanin content were determined spectrophotometrically.&lt;strong&gt; Results: &lt;/strong&gt;The results showed that the aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; fruit pericarps had a phenolic (26.33 ± 0.77 mg GAE/g plant extract) and flavonoid content (9.31 ± 0.40 mg QE/g plant extract). The aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; significantly inhibited mushroom tyrosinase activity (IC&lt;sub&gt;50&lt;/sub&gt; of 40.72 ± 1.83 μg/mL) and cellular tyrosinase activity (at a concentration of 125 μg/mL) in α-melanocyte stimulating hormone-induced B16F10 melanoma cells. The &lt;em&gt;Garcinia atroviridis &lt;/em&gt;extract also suppressed melanin content at concentrations of 31.25-125 μg/mL. Correlations of mushroom tyrosinase inhibition with DPPH and ABTS scavenging activities were 0.8673 and 0.9468, respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings show that an aqueous extract of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; fruit pericarps is a source of natural compounds and antioxidant capacity which can inhibit tyrosinase activity and melanin content. Thus, aqueous extracts of &lt;em&gt;Garcinia atroviridis&lt;/em&gt; may be a potential source of skin whitening agents for hyperpigmentation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Moragot Chatatikun&lt;sup&gt;1,2,3&lt;/sup&gt;, Pitaksit Supjaroen&lt;sup&gt;1&lt;/sup&gt;, Patcharaporn Promlat&lt;sup&gt;1&lt;/sup&gt;, Chantanapa Chantarangkul&lt;sup&gt;1&lt;/sup&gt;, Sutida Waranuntakul&lt;sup&gt;1&lt;/sup&gt;, Jiraphat Nawarat&lt;sup&gt;4&lt;/sup&gt;, Jitbanjong Tangpong&lt;sup&gt;1,2,3&lt;/sup&gt;, Anchalee Chiabchalard&lt;sup&gt;5,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Excellence Center for Innovation and Health Product, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center of Excellence Research for Meliodosis (CERM), Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Physical Therapy, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Phakamani Hopewell Tsilo</style></author><author><style face="normal" font="default" size="100%">Sidney Tsolanku Maliehe</style></author><author><style face="normal" font="default" size="100%">Jabulani Siyabonga Shandu</style></author><author><style face="normal" font="default" size="100%">Rene Khan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Some Biological Activities of the Methanolic Encephalartos ferox Fruit Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-quorum sensing</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1190-1197</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Although literature reports the therapeutic properties of &lt;em&gt;Encephalartos ferox&lt;/em&gt;, there are limited pharmacological studies of its fruit. &lt;strong&gt;Objective: &lt;/strong&gt;This study sought to evaluate the antibacterial, antioxidant, anti-quorum sensing and &lt;em&gt;in vitro &lt;/em&gt;cytotoxic activities of the methanolic&lt;em&gt; E. ferox&lt;/em&gt; fruit extract. &lt;strong&gt;Methods: &lt;/strong&gt;The chemical constituent of the methanolic fruit extract was analysed using gas chromatography-mass spectrometry. Antibacterial activity of the extract was investigated against &lt;em&gt;Staphylococcus aureus &lt;/em&gt;(ATCC 25923), &lt;em&gt;Bacillus cereus&lt;/em&gt; (ATCC 10102), &lt;em&gt;Escherichia coli &lt;/em&gt;(ATCC 25922) and &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; (ATCC 27853) using the broth dilution method. The standard 2.2-diphenyl-1-picrylhydrazyl (DPPH) and 2.2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used to evaluate the scavenging activities of the extract. Anti-quorum sensing activity was assessed against biosensor strain- &lt;em&gt;Chromobacterium violaceum &lt;/em&gt;(ATCC 12472). Cytotoxicity in HepG2 cells was investigated using the tetrazolium-based colorimetric (MTT) assay. &lt;strong&gt;Results: &lt;/strong&gt;The extract revealed eight volatile compounds with cis-Vaccenic acid (87.06%) and 9-Octadecenoic acid, 1,2,3-propanetriyl ester (5.21%) as the major components. Antibacterial activity against all tested strains with minimum inhibitory concentration range of 1.56 - 12.5 mg/mL was observed. The DPPH and ABTS assays demonstrated scavenging activities with the median inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values of 0.09 mg/mL and 0.003 mg/mL, respectively. The extract also displayed strong anti-quorum sensing activity with 93% inhibition of violacein production at 25 mg/mL. A half maximum inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) of 5370 μg/mL was computed in HepG2 cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; The extract has potential to be used as a source of therapeutic compounds in pharmaceutical applications.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1190</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Phakamani Hopewell Tsilo&lt;sup&gt;1,&lt;/sup&gt;*, Sidney Tsolanku Maliehe&lt;sup&gt;1&lt;/sup&gt;, Jabulani Siyabonga Shandu&lt;sup&gt;1&lt;/sup&gt;, Rene Khan&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa 3886, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Discipline of Medical Biochemistry, College of Health Sciences, University of KwaZulu- Natal, Private Bag X 54001, Durban 4000, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manish Kumar</style></author><author><style face="normal" font="default" size="100%">Ankita Misra</style></author><author><style face="normal" font="default" size="100%">Akanksha Srivastava</style></author><author><style face="normal" font="default" size="100%">Pushpendra Kumar Shukla</style></author><author><style face="normal" font="default" size="100%">L M Tewari</style></author><author><style face="normal" font="default" size="100%">Sharad Srivastava</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Pharmacognostical and Pharmacological Evaluation of Costus speciosus (Koen) J.E. Sm. Germplasm Collected from Eastern Ghats of India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Costus speciosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Diosgenin</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">150-156</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Costus speciosus &lt;/em&gt;is an erect perennial herb belonging to family Costaceae, an important medicinal plant widely used in several indigenous medicinal formulations. &lt;strong&gt;Objective: &lt;/strong&gt;A comparative evaluation of Pharmacognostical and Pharmacological potential of &lt;em&gt;Costus speciosus &lt;/em&gt;for the validation of traditional claims and quality parameters for industry. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Pharmacognostical studies were performed as per Ayurvedic Pharmacopeia of India and quantification of diosgenin was done through HPTLC. &lt;em&gt;In vitro&lt;/em&gt; antidiabetic activity was evaluated by α-amylase inhibition assay based on starch iodine method and &lt;em&gt;in vitro &lt;/em&gt;anti-inflammatory were done by using inhibition of protein denaturation assay. &lt;strong&gt;Results: &lt;/strong&gt;The pharmacognostical standards were also laid down for each sample. Morpho-anatomical characters had no distinct variation in all the collected samples of Eastern Ghats. The quantification of diosgenin (without hydrolysis of samples) in the collected germplasm varies significantly from 0.002 to 0.076 % on dry weight basis. The maximum content was recorded in NBCS-06 from Patiya, Bhubaneswar and was identified as distinct chemotype with high metabolite content. IC&lt;sub&gt;50&lt;/sub&gt; value of&lt;em&gt; Costus speciosus &lt;/em&gt;extract in starch-iodine assay was found to be maximum in NBCS- 6 (87.54 μg/ml) and inhibition of protein denaturation assay was found to be maximum in NBCS- 11 (73.91 μg/ml), respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study suggests that the &lt;em&gt;Costus speciosus&lt;/em&gt; germplasm possess potential anti-inflammatory and anti-diabetic activity and comparative pharmacognostical parameters will be useful in collection of location specific potential samples for industrial usage along with quality control of raw materials.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Manish Kumar&lt;sup&gt;1,2&lt;/sup&gt;, Ankita Misra&lt;sup&gt;1&lt;/sup&gt;, Akanksha Srivastava&lt;sup&gt;1&lt;/sup&gt;, Pushpendra Kumar Shukla&lt;sup&gt;1&lt;/sup&gt;, L. M. Tewari&lt;sup&gt;2&lt;/sup&gt;, Sharad Srivastava&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Division, CSIR-National Botanical Research Institute, Lucknow (U.P.) 226001, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, D.S.B. Campus, Kumaun University, Nainital-263002, Uttarakhand, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surya Dwira</style></author><author><style face="normal" font="default" size="100%">Ariska TP</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Cytotoxicity between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against HeLa Cervical Cancer Cell Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia rotunda</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1297-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to compare between ethanol and ethyl acetate rhizome extract of &lt;em&gt;K.rotunda &lt;/em&gt;against HeLa cervical cancer cell &lt;em&gt;in vitro. &lt;/em&gt;&lt;strong&gt;Material and Methods: &lt;/strong&gt;Methods used in this research are test the chemical compound of extracts using Thin Layer Chromatography (TLC) and phytochemical screening test, also cytotoxicity test using MTT assay. &lt;strong&gt;Result:&lt;/strong&gt; Ethyl acetate extract contains flavonoid, alkaloid, tannin, and triterpenoid, while ethanol extract have flavonoid, triterpenoid, and alkaloid. In addition, ethanol extract has strong cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 16,939 μg/ml) while ethyl acetate extract has moderate cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 127,9 μg/ml). Each of extracts showed significant results (p ≤ 0,05) although when compared between concentrations there are several concentrations that are not significant and also small coefficient of determinant values caused by various confounding factors. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of &lt;em&gt;K.rotunda &lt;/em&gt;rhizome extract has the higher cytotoxicity activity compared to ethyl acetate extract of&lt;em&gt; K.rotunda&lt;/em&gt; rhizome extract against HeLa cervical cancer cell.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Surya Dwira&lt;sup&gt;1&lt;/sup&gt;, Ariska TP&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,3,&lt;/sup&gt;*, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Linda Erlina&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tsolanku Sidney Maliehe</style></author><author><style face="normal" font="default" size="100%">Phakamani Hopewell Tsilo</style></author><author><style face="normal" font="default" size="100%">Jabulani Siyabonga Shandu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Computational Evaluation of ADMET Properties and Bioactive Score of Compounds from Encephalartos ferox</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive score</style></keyword><keyword><style  face="normal" font="default" size="100%">Compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacokinetic; Drug-likeness</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1357-1362</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Plant based products are recognised as sources of drugs for treatment of diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The study aimed at predicting the physicochemical, pharmacokinetics, drug-likeness and toxicity of the compounds identified from the methanolic &lt;em&gt;Encephalartos ferox&lt;/em&gt; fruit extract. &lt;strong&gt;Methods: &lt;/strong&gt;The physicochemical, pharmacokinetics properties and bioactive scores of the compounds were predicted using SwissADME and Molinspiration computational tools. Drug-likeness of the compounds was evaluated based on the Lipinski rule of five (Ro5).&lt;em&gt; In silico&lt;/em&gt; mutagenicity, carcinogenicity and inhibition of human ether-a-go-go-related (hERG) gene were also investigated using PreADMET web tool. &lt;strong&gt;Results: &lt;/strong&gt;The physicochemical properties showed the compounds, except 9-Octadecenoic acid, 1, 2, 3-propanetriyl ester to adhere to Ro5. The evaluation of their inhibitory effects profile in several cytochrome P450 isoforms indicate that all the compounds are not the inhibitors of CYP2C19 and CYP3A4 whereas some inhibited CYP1A2, CYP2C9 and CYP2D6. The drug-likeness evaluation employed Ro5 as a filter and all compounds complied with it except for 9-Octadecenoic acid, 1, 2, 3-propanetriyl ester. About 50% of the tested compound were found to be safe as they did not exhibit antimutagenic and carcinogenic effects. Moreover, the risk of inhibition of hERG gene revealed to be low to medium risk depending on the compound. &lt;strong&gt;Conclusion: &lt;/strong&gt;The calculated physicochemical and pharmacokinetic properties suggest that most of the compounds are safe and have promising oral bioavailability.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1357</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tsolanku Sidney Maliehe&lt;sup&gt;1,&lt;/sup&gt;*, Phakamani Hopewell Tsilo&lt;sup&gt;1&lt;/sup&gt;, Jabulani Siyabonga Shandu&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Zululand, KwaDlangezwa 3886, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferubko EV</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correction of Toxic Liver Damage with a Multicomponent Herbal Extract in an Animal Experiment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Choleretic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental hepatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Multicomponent extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">168-172</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Digestive diseases constitute a significant part in the overall structure of human diseases. Herbal cholagogues are indicated for a treatment of chronic liver, gall bladder, and bile ducts diseases. The aim of the work is to determine the choleretic effect of a new multicomponent plant extract.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Multicomponent plant extract was obtained from the following types of plant materials: 300 g of immortelle flowers (&lt;em&gt;Helichrysum arenarium&lt;/em&gt; L.), 100 g of tansy flowers (&lt;em&gt;Tanacetum vulgare&lt;/em&gt; L.), 100 g of rose fruits (&lt;em&gt;Rosa &lt;/em&gt;sp.), 100 g of leaves of common nettle (&lt;em&gt;Urtica dioica &lt;/em&gt;L.), 50 g of mint leaves (&lt;em&gt;Mentha piperita&lt;/em&gt; L.), 50 g of licorice roots (&lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; L.). The extract was standardized by the total flavonoid content. It was calculated and expressed in terms of luteolin and isosalipurposide standards (total flavonoids content: not less than 4% and 15% respectively). The animal experiments being done in 80 nonlinear male rats with initial body weight 180-200 g. In order to study a choleretic effect of multicomponent herbal extract, naive rats recieved the single experimental dose of 250 mg/kg. Pharmacotherapeutic activity was studied in white rats with CCl&lt;sub&gt;4&lt;/sub&gt;-induced hepatitis. &lt;strong&gt;Results: &lt;/strong&gt;Studies indicate a pronounced choleretic effect of the studied plant extract, that is comparable with the effect of “Allochol” in intact rats experiments. The course administration of a per os (peroral) multicomponent plant extract in a dose of 250 mg/kg to white non-linear rats with tetrachloromethane liver damage has a choleretic effect: it increases the rate of bile secretion, stimulates the synthesis and secretion of cholates with bile, and also the excretion of cholesterol and bilirubin. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained research results argue the feasibility of using a multicomponent plant extract containing biologically active substances of phenolic nature in the prevention and comprehensive treatment of liver diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">168</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ferubko EV&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Rendyuk TD&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">NadzilaAnindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Rista Putrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity of Soursop Leaves (Annona muricata) against Cervical HeLa Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Soursop</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cervical cancer is the cancer with highest prevalence and the leading cause of women death in Indonesia. Current treatments available for cervical cancer are chemotherapy, radiation, surgery, and nuclear therapy. Unfortunately, these treatments still have several limitations due to serious side effects, development of resistance, and very expensive price. Therefore, it is necessary to develop effective and low-cost therapy to treat cervical cancer. One of which is by utilizing natural sources available in Indonesia such as soursop (&lt;em&gt;Annona muricata&lt;/em&gt;) leaves which has been used in folk medicine as a treatment for various diseases, including cancer. However, studies about its cytotoxicity against cervical cancer in Indonesia are still limited. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this research is to analyze the potency of &lt;em&gt;A.muricataleaves&lt;/em&gt; extracts originated from Indonesia as a novel alternative treatment for cervical cancer. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;&lt;em&gt;A.muricata&lt;/em&gt; leaves obtained from Serpong, West Java, Indonesia were grounded and macerated in three different solvents with various polarity, namely ethanol (polar solvent), ethyl acetate (semipolar solvent) and hexane (non-polar solvent). Subsequently, the extracts were diluted into 8 various concentrations. Cytotoxicity of &lt;em&gt;A.muricataleaves &lt;/em&gt;extracts against HeLa cervical cancer cells were determined by MTT assay and expressed by IC&lt;sub&gt;50 &lt;/sub&gt;value.&lt;strong&gt; Results: &lt;/strong&gt;The results showed that three extracts of &lt;em&gt;A.muricata&lt;/em&gt; have strong cytotoxicity against cervical HeLa cells. The highest cytotoxic activity was shown by etanol extract with an IC&lt;sub&gt;50&lt;/sub&gt; of 35.51 μg/mL, followed by ethyl acetate (IC&lt;sub&gt;50&lt;/sub&gt;: 5.91 μg/mL), and hexane (IC&lt;sub&gt;50&lt;/sub&gt;: 8.39 μg/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;A.muricata &lt;/em&gt;leaves extracts are potential to be developed as a novel alternative therapy for cervical cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, NadzilaAnindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Rista Putrianingsih&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zaichikova SG</style></author><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Kiselevskii MV</style></author><author><style face="normal" font="default" size="100%">Antsyshkina AM</style></author><author><style face="normal" font="default" size="100%">Bondar AA</style></author><author><style face="normal" font="default" size="100%">Prostodusheva TV</style></author><author><style face="normal" font="default" size="100%">Shchepochkina OYu</style></author><author><style face="normal" font="default" size="100%">Gegechkori VI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of the Chemical Composition of Lady’s Bedstraw (Galium verum L.) Herb Extract by GC-MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Galium verum L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas chromatography-mass spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Lady’s bedstraw</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">857-863</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The research is devoted to the study of the Lady’s bedstraw (&lt;em&gt;Galium verum&lt;/em&gt; L.) herb ethanol extract composition using the method of gas chromatography with mass spectrometric detection. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Air-dried &lt;em&gt;G. verum&lt;/em&gt; L. herb was used for ethanol extract preparation. Hewlett Packard 6890, 5973A GC/MSD System equipped with an HP-5MS quartz capillary column with geometric dimensions of 30 m×0.25 mm×0.25 μm was used for GC-MS analysis. &lt;strong&gt;Results: &lt;/strong&gt;It was established that the Lady’s bedstraw ethanol extract is rich in biologically active substances that determine its wide spectrum of pharmacological action. 15 compounds were identified by comparing with library mass spectra. &lt;strong&gt;Conclusions: &lt;/strong&gt;&lt;em&gt;G. verum&lt;/em&gt; L. is a promising source of crude herbal drugs. In the future, after additional pharmacognostic studies, &lt;em&gt;G. verum&lt;/em&gt; L. herb can be recommended for implementation in the State Pharmacopeia of the Russian Federation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">857</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zaichikova SG&lt;sup&gt;1&lt;/sup&gt;, Bokov DO&lt;sup&gt;1,2,&lt;/sup&gt;*, Kiselevskii MV&lt;sup&gt;3&lt;/sup&gt;, Antsyshkina AM&lt;sup&gt;1&lt;/sup&gt;, Bondar AA&lt;sup&gt;1&lt;/sup&gt;, Prostodusheva TV&lt;sup&gt;1&lt;/sup&gt;, Shchepochkina OYu&lt;sup&gt;1&lt;/sup&gt;, Gegechkori VI&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;A.P. Nelyubin Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Cell-Mediated Immunity, Blokhin National Medical Research Center of Oncology, 24, Kashirskoye sh., Moscow, 115478, RUSSIAN FEDERATION.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ferubko EV</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development and Evaluation of New Choleretic Agent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Choleretic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Choleretic herbal medicine Hexaphyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Experimental damage of liver and gallbladder</style></keyword><keyword><style  face="normal" font="default" size="100%">Preclinical studies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">962-966</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The aim of the research is the determination of pharmacological activity during the development of the optimal way of a new choleretic agent obtaining. The multicomponent herbal medicinal product under the code name Hexaphyte (herbal multicomponent dry extract) is developed. It contains the following species of medicine plant raw materials: &lt;em&gt;Helichrysum arenarium&lt;/em&gt; L., &lt;em&gt;Tanacetum vulgare&lt;/em&gt; L., R&lt;em&gt;osa sp&lt;/em&gt;., &lt;em&gt;Urtica dioica&lt;/em&gt; L., &lt;em&gt;Mentha piperita&lt;/em&gt; L., &lt;em&gt;Glycyrrhiza glabra&lt;/em&gt; L. in the ratio of 6:2:2:2:1:1. Materials and Methods: Herbal tea was extracted three times with hot water at the temperature of 75-85ºС; water extracts were combined, filtered and dried. Hexaphyte was standardized by the content of phenolic compounds – sum of flavonoids in terms of luteolin standard and isosalipurposide standard. Phenolic compounds (flavonoids) are dominating substances (35-37%) in the obtained extract. The obtained multicomponent medicine under the code name Hexaphyte was administered per os in the experimental and therapeutic dose of 250 mg/kg to the laboratory animals having experimental induced damages of gallbladder and liver. &lt;strong&gt;Results:&lt;/strong&gt; In Hexaphyte the content of the flavonoid sum (CFS) referred to luteolin standard at a wavelength of 350 nm was not less than 4%; CFS referred to isosalipurposide standard at a wavelength of 315 nm was not less than 15%. It was revealed in the results of the realized experiments that it has a choleretic effect superior in a number of indicators to the activity of the Allochol reference drug. The pharmacotherapeutic effect of Hexaphyte at experimental damages of gallbladder and liver is due to the presence of biologically active substances, mainly of phenolic nature. &lt;strong&gt;Conclusion: &lt;/strong&gt;The obtained results of the research argue the feasibility of using the developed multicomponent medicine Hexaphyte containing biologically active substances of phenolic nature in the prevention and complex treatment of hepatobiliary system diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">962</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ferubko EV&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lulu Adilla Latifah</style></author><author><style face="normal" font="default" size="100%">Nunuk Hariani Soekamto</style></author><author><style face="normal" font="default" size="100%">Akbar Tahir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green Algae Halimeda macroloba in Spermonde Archipelago: Phytochemical and in vitro Antibacterial Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Halimeda macroloba</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Shrimp Pathogenic Bacteria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1000-1004</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Green algae&lt;em&gt; Halimeda macroloba&lt;/em&gt; compounds active against human, fish, and shrimp pathogenic bacteria. It is one of the marine natural organisms (MNO) which is a diverse source of secondary metabolites. &lt;strong&gt;Objective:&lt;/strong&gt; We have set our goal towards determining the antimicrobial potential of crude extracts of green algae &lt;em&gt;H. macroloba&lt;/em&gt;. Materials and Methods: Three crude mixtures of Marine Natural Product (MNP) were obtained from macroalgae &lt;em&gt;Halimeda macroloba&lt;/em&gt; (Lae-Lae island, Spermonde Archipelago) by extraction (n-hexane, ethyl acetate, and methanol were used as solvents). &lt;strong&gt;Results:&lt;/strong&gt; Theses mixtures (phytochemical tests showed they contained steroids, terpenoids, and alkaloids) were screened for their activity against shrimp pathogenic bacteria (&lt;em&gt;Vibrio harveyi (&lt;/em&gt;M-120), &lt;em&gt;Aeromonas hydrophilla&lt;/em&gt;&amp;nbsp;and &lt;em&gt;Vibrio parahaemolyticus&lt;/em&gt; (T-170)). The obtained results confirmed weak antibacterial activity of studied extracts of&lt;em&gt; H. macroloba. &lt;/em&gt;The ethyl acetate extract was the most potent antimicrobial agent at a concentration of 4 μg/25 μl. The inhibition zones for the growth of A. hydrophilla (the most susceptible microorganism) and &lt;em&gt;V. harveyi &lt;/em&gt;were at 8.27 mm and 8.23 mm, respectively (inhibition zone was 15.2 mm for ciprofloxacin which was used as a positive control). &lt;strong&gt;Conclusion: &lt;/strong&gt;They might be even used in the future as alternatives to conventional drugs in aquaculture.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1000</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lulu Adilla Latifah&lt;sup&gt;1&lt;/sup&gt;, Nunuk Hariani Soekamto&lt;sup&gt;2&lt;/sup&gt;, Akbar Tahir&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Fisheries Science Department, Faculty of Marine Science and Fisheries, Hasanuddin University, Makassar, 90245, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Mathematics and Natural Sciences Faculty, Hasanuddin University, Makassar, 90245, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Marine Science Department, Faculty of Marine Science and Fisheries, Hasanuddin University, Makassar, 90245, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shashank Tiwari</style></author><author><style face="normal" font="default" size="100%">Shreya Talreja</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Importance of Cinnamomum Tamala in the Treatment of Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum tamala</style></keyword><keyword><style  face="normal" font="default" size="100%">Diseases</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Uses</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1792-1796</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Cinnamomum tamala&lt;/em&gt; is a multipurpose evergreen plant it is a native of India. The plant is commonly known as Indian cassia, Tejpatta, Indian bay leaf etc. All parts of plant possess many major bioactive constituent due to the presence of major phytoconstituent it is useful for the treatment of various diseases or disorders such as Cancer, cardiac diseases, diabetes, Anxiety, depression, ulcer, GI diseases and possess many pharmacological activity includes anti-oxidant, anti-hypercholesterolemia, anti-diarrhoeal, anti-inflammatory, anti-fungal, antibacterial etc. In Ancient time the plant also used as for its medicinal value and it contains a aromatic property due to the presence of these property it is used in perfumery industry and used as mouth refreshing, useful for removal of bad odour from body, mouth and also used in pharmaceutical industries. The leaves of the plant possess flavouring agent property it is used as a flavouring agent in food, curry, fast food, pickles and used as a spice. The main aim of this review/study was to promote and upgrade the knowledge of the use of this multipurpose evergreen plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1792</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shashank Tiwari&lt;sup&gt;1,&lt;/sup&gt;*, Shreya Talreja&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Director (Academic and Research), Lucknow Model College of Pharmacy, Lucknow, INDIA. Shreya Talreja, Lecturer, Lucknow Model College of Pharmacy, Lucknow, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer, JP College of Pharmacy, Lucknow, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fendi Yoga Wardana</style></author><author><style face="normal" font="default" size="100%">Defi Kartika Sari</style></author><author><style face="normal" font="default" size="100%">Myrna Adianti</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Tomoyoshi Nozaki</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Anti-Amebic Activity of Cage Xanthones from Cratoxylum sumatranum Stem Bark Against Entamoeba histolytica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amoebiasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactivity-guided isolation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cratoxylum sumatranum</style></keyword><keyword><style  face="normal" font="default" size="100%">Entamoeba histolytica</style></keyword><keyword><style  face="normal" font="default" size="100%">NAD kinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">452-458</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Amoebiasis is caused by&lt;em&gt; Entamoeba histolytica,&lt;/em&gt; which is a pathogenic species living on human colon tissues. The development of new drugs for anti-amebic are still very needed for clinical treatment. &lt;strong&gt;Objective: &lt;/strong&gt;This aims to identify the compounds in &lt;em&gt;Cratoxylum sumatranum&lt;/em&gt; for their anti-amoeba activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;In this study we used bioactivity-guided isolation and structural analysis to identified anti-amebic compounds from dichloromethane extract of &lt;em&gt;Cratoxylum sumatranum&lt;/em&gt; stem bark. Their anti-amebic activity was determined by an &lt;em&gt;in vitro&lt;/em&gt; cell-based assay against&lt;em&gt; Entamoeba histolytica &lt;/em&gt;and an enzymatic assay on NAD kinase.&lt;strong&gt; Results:&lt;/strong&gt; Two known compounds from the cage xanthone groups, namely cochinchinoxanthone (1) and cochinchinone D (2), were isolated. The structures of the cage xanthone compounds were established by extensive spectroscopic data analysis. Compound (1) showed the greatest level of anti-amebic activity both in cell-based and enzymatic assay, yielding IC&lt;sub&gt;50&lt;/sub&gt; values of 4.57 and 12.17 μg/mL, respectively. In contrast, compound (2) yielded IC&lt;sub&gt;50&lt;/sub&gt; values of 5.19 and 12.60 μg/mL, respectively. Conclusion: When considering the demonstrated anti-amebic activities, it becomes apparent that these compounds, isolated from &lt;em&gt;Cratoxylum sumatranum &lt;/em&gt;stem bark, have the potential to be further developed into effective anti-amebic medicine against &lt;em&gt;Entamoeba histolytica.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">452</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Fendi Yoga Wardana&lt;sup&gt;1&lt;/sup&gt;, Defi Kartika Sari&lt;sup&gt;2&lt;/sup&gt;, Myrna Adianti&lt;sup&gt;2,3&lt;/sup&gt;, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Tomoyoshi Nozaki&lt;sup&gt;4&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;2,5&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;2,5,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Faculty of Vocational Education, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of School of International Health, Laboratorium of Biomedical Chemistry, The University of Tokyo, Tokyo, 113-0033, JAPAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Gerry Kurniawan</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A549 Lung Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549 Lung Cancer Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Hibiscus sabdariffa Linn</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">14-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Lung cancer is the one of the leading causes of cancer death. However, current treatments for lung cancer are expensive and show negative side effects. Therefore, the study concerning natural anticancer from plants has intensified. &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn are Indonesian herb plants which have been consumed as a drink, are known to have anticancer activity against several cancer cell lines. However, its potential cytotoxic activity on A549 lung cancer cell line is still unclear. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to identify cytotoxic activity of &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn extracts on A549 lung cancer cell line. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;&lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn flowers from Tangerang, province of Banten, Indonesia, were macerated in three different solvents: ethyl acetate, ethanol, and n-hexane. Afterwards, cytotoxic activity of &lt;em&gt;Hibiscus sabdariffa &lt;/em&gt;Linn extracts on A549 lung cancer cell line were evaluated using MTT assay. There were eight variety of concentration of the extracts, the experiment has been done triplicate for each concentration. The anticancer activity is expressed by IC&lt;sub&gt;50&lt;/sub&gt; value. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn extracts in ethanol, ethyl acetate, and n-hexane showed IC&lt;sub&gt;50&lt;/sub&gt; value of 374.01 μg/mL, 719.28 μg/mL, and 906.57 μg/mL respectively, in which indicated weak cytotoxic activity on A549 lung cancer cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol, ethyl acetate, and n-hexane extracts of &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn are potential to be further developed as natural anticancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">14</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Gerry Kurniawan&lt;sup&gt;1&lt;/sup&gt;, Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Nadzila Anindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Barkalova VE</style></author><author><style face="normal" font="default" size="100%">Suslikova MA</style></author><author><style face="normal" font="default" size="100%">Sokhin DM</style></author><author><style face="normal" font="default" size="100%">Kakhramanova SD</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Strelyaeva AV</style></author><author><style face="normal" font="default" size="100%">Antsyshkina AM</style></author><author><style face="normal" font="default" size="100%">Balobanova NP</style></author><author><style face="normal" font="default" size="100%">Prostodusheva TV</style></author><author><style face="normal" font="default" size="100%">Grikh VV</style></author><author><style face="normal" font="default" size="100%">Krasnyuk II1 (junior)</style></author><author><style face="normal" font="default" size="100%">Marakhova AI</style></author><author><style face="normal" font="default" size="100%">Moiseev DV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lathraea squamaria L. (Orobanchaceae): A Review of its Botany, Phytochemistry, Traditional Uses and Pharmacology</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aucubin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Common toothwort</style></keyword><keyword><style  face="normal" font="default" size="100%">Iridoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Lathraea squamaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Orobanchaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Parasitic plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">667-673 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This paper presents the results of the review pharmacognostic study of common toothwort, a perennial plant, parasitizing on the roots of trees. Currently, in Russian traditional medicine, there is considerable experience in the use of сommon toothwort (&lt;em&gt;Lathraea squamaria&lt;/em&gt; L.) herb and roots as antitumoral, biligenic, infertility-treatment and diuretic drugs. The chemical composition of &lt;em&gt;L. squamaria&lt;/em&gt; has not been quite well determined. Phenylethanoid glycosides (acteoside, isoacteoside), iridoid glycosides (aucubin, and aucuboside ester, 6'-O-glucopyranosyl-aucubin, melampyroside, 6'-O-glucopyranosyl melampyroside), simple sugars, fatty acids, organic acids, β-sitosterol were identified. Further study of&lt;em&gt; L. squamaria &lt;/em&gt;raw materials is a very promising field including implementation in official medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">667</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bokov DO&lt;sup&gt;1,2,#,&lt;/sup&gt;*, Barkalova VE&lt;sup&gt;3,#&lt;/sup&gt;, Suslikova MA&lt;sup&gt;1&lt;/sup&gt;, Sokhin DM&lt;sup&gt;1&lt;/sup&gt;, Kakhramanova SD&lt;sup&gt;1,4&lt;/sup&gt;, Rendyuk TD&lt;sup&gt;1&lt;/sup&gt;, Strelyaeva AV&lt;sup&gt;1&lt;/sup&gt;, Antsyshkina AM&lt;sup&gt;1&lt;/sup&gt;, Balobanova NP&lt;sup&gt;1&lt;/sup&gt;, Prostodusheva TV&lt;sup&gt;1&lt;/sup&gt;, Grikh VV&lt;sup&gt;1&lt;/sup&gt;, Krasnyuk II&lt;sup&gt;1&lt;/sup&gt; (junior), Marakhova AI&lt;sup&gt;5&lt;/sup&gt;, Moiseev DV&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pediatrics, Siberian State Medical University, 2 Moscow tract, 634050, Tomsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of State Pharmacopoeia and pharmacopoeia analysis, Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products”, 8/2 Petrovsky Boulevard, Moscow, 127051, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmaceutical chemistry and pharmacognosy chair, Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Chair of Standardization of Medicines, Vitebsk State Medical University, 27, Frunze avenue, Vitebsk, 210062, BELARUS. #Bokov DO, Barkalova V.E. contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Didin Wahyu Agustina</style></author><author><style face="normal" font="default" size="100%">Mulya Dwi Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Sri Widyarti</style></author><author><style face="normal" font="default" size="100%">Aris Soewondo</style></author><author><style face="normal" font="default" size="100%">Hideo Tsuboi</style></author><author><style face="normal" font="default" size="100%">Muhaimin Rifa’i</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Noni Juice (Morinda citrifolia) to Prevent Cancer Progression in Mice Induced DMBA and Cigarette Smoke Exposure</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Homeostatic</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunotoxin</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Noni juice</style></keyword><keyword><style  face="normal" font="default" size="100%">Tumor progression</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">946-951</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Accumulation of polycyclic aromatic hydrocarbons (PAH) in the body commonly lead to degenerative disease such as cancer. This study aims to investigate the potential of &lt;em&gt;Morinda citrifolia&lt;/em&gt; to maintain the immune system against toxic exposure. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study used Five weeks old male Balb/C mice as animal model. The 7,12-Dimethylbenz(a)anthracene (DMBA) was administrated for six weeks following with 3 days cigarette smoke (CS) exposure then treated with noni juice (&lt;em&gt;M. citrifolia&lt;/em&gt;) for two weeks. Experimental animals were divided into six groups. Normal control (N); DMBA+CS; Cisplatin; D1; D2; and D3. Profil of CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt;, CD11b+IL6&lt;sup&gt;+&lt;/sup&gt;, CD11b&lt;sup&gt;+&lt;/sup&gt;IFNγ&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;+&lt;/sup&gt; IL10&lt;sup&gt;+&lt;/sup&gt;, NK&lt;sup&gt;+&lt;/sup&gt;IL6&lt;sup&gt;+&lt;/sup&gt; cells was analyzed by flow cytometry and data was analyzed with one-way ANOVA and Post Hoc Tukey HSD test with a significance of p-values &amp;lt; 0.05. &lt;strong&gt;Results:&lt;/strong&gt; This study show that DMBA+CS induction increasing level of CD11b&lt;sup&gt;+&lt;/sup&gt;IL6&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt;CD25&lt;sup&gt;+&lt;/sup&gt; IL-10&lt;sup&gt;+&lt;/sup&gt; and NK&lt;sup&gt;+&lt;/sup&gt; IL-6&lt;sup&gt;+&lt;/sup&gt; meanwhile decreasing CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt;significantly (P&amp;lt;0.5) than Normal group. Noni juice in dose 90 mg/Kg BW decrease cytokine pro-inflammation (IL-6 and IFNγ) both in macrophage and NK cell profile significantly (P&amp;lt;0.05). Noni juice in 30 mg/Kg BW could improve the activation CD4&lt;sup&gt;+&lt;/sup&gt;TNFα&lt;sup&gt;+&lt;/sup&gt; significantly (P&amp;lt;0.05). Noni juice also has efficacy to control T regulator activation to prevent tumor escape. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results suggest that noni juice has anti-cancer potencies by maintain homeostasis of immune system and could be immune herbal supplement.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">946</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Didin Wahyu Agustina&lt;sup&gt;1&lt;/sup&gt;, Mulya Dwi Wahyuningsih&lt;sup&gt;1&lt;/sup&gt;, Sri Widyarti&lt;sup&gt;1&lt;/sup&gt;, Aris Soewondo&lt;sup&gt;1&lt;/sup&gt;, Hideo Tsuboi&lt;sup&gt;3&lt;/sup&gt;, Muhaimin Rifa’i&lt;sup&gt;1,2&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Biology Department, Faculty of Mathematics and Natural sciences, Brawijaya University. Malang 65145, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Biosystems Research Center, LPPM University of Brawijaya, Malang 65145, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Immunology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yuliana Salosso</style></author><author><style face="normal" font="default" size="100%">Siti Aisiah</style></author><author><style face="normal" font="default" size="100%">Lumban Nauli Lumban Toruan</style></author><author><style face="normal" font="default" size="100%">Wesly Pasaribu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nutrient Content, Active Compound and Antibacterial Activity of Padina australis against Aeromonas hydropilla</style></title><secondary-title><style face="normal" font="default" size="100%">Active compound, Antibacterial activity, Padina australis, Nutrient content,</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Active compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutrient content</style></keyword><keyword><style  face="normal" font="default" size="100%">Padina australis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">771-776</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Padina australis &lt;/em&gt;is one of the brown macroalgae that possess several compounds that can be used for various medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to analyze the nutrient content, active compounds, and antibacterial activity of &lt;em&gt;Padina australis&lt;/em&gt; against &lt;em&gt;Aeromonas hydropilla.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; The nutrient content and phytochemical composition of&lt;em&gt; P. australis&lt;/em&gt; were examined in this study. The antibacterial effect was evaluated using the disc method against &lt;em&gt;A. hydropilla.&lt;/em&gt; &lt;strong&gt;Results:&lt;/strong&gt; The nutrient content of &lt;em&gt;P. australis&lt;/em&gt; include 38.5% carbohydrate, 2.07% fat, 13.89% protein, 16.12% water, 33.34% ash, 8.54% total amino acid, and minerals (11.36% calcium, 0.22% iron, and 1.81% potassium). Phytochemical analysis showed that &lt;em&gt;P. australis &lt;/em&gt;contained phenols, tannin, flavonoid, and steroid. These compound may be responsible for inhibiting &lt;em&gt;A. hydropilla,&lt;/em&gt; with an inhibition zone of 10.5 mm for water extract of &lt;em&gt;P. australis &lt;/em&gt;and 10 mm for methanol extract &lt;em&gt;P. australis.&lt;/em&gt; &lt;strong&gt;Conclusion: &lt;/strong&gt;This study revealed that &lt;em&gt;P. australis&lt;/em&gt; produced antibacterial effect against &lt;em&gt;A. hydropilla&lt;/em&gt; which could be potential for further antimicrobial agent development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">771</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yuliana Salosso&lt;sup&gt;1,&lt;/sup&gt;*, Siti Aisiah&lt;sup&gt;2&lt;/sup&gt;, Lumban Nauli Lumban Toruan&lt;sup&gt;3&lt;/sup&gt;, Wesly Pasaribu&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Aquaculture, Faculty of Fisheries and Marine Science, Nusa Cendana University, Kupang 85228, East Nusa Tenggara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Aquaculture, Lambung Mangkurat University, Banjarbaru 70711, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Study Program of Aquatic Resource Management, Faculty of Fisheries and Marine Science, Nusa Cendana University, Kupang 85228, East Nusa Tenggara, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Dhanalakshmi</style></author><author><style face="normal" font="default" size="100%">N Harikrishnan</style></author><author><style face="normal" font="default" size="100%">N Srinivasan</style></author><author><style face="normal" font="default" size="100%">P Pandian</style></author><author><style face="normal" font="default" size="100%">BA Tanisha</style></author><author><style face="normal" font="default" size="100%">M Tharun Kumar</style></author><author><style face="normal" font="default" size="100%">V Lokesh</style></author><author><style face="normal" font="default" size="100%">N Yuvashri</style></author><author><style face="normal" font="default" size="100%">S Supriya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Perspective Overview on Hygrophila auriculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hygrophila auriculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1748-1752</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Hygrophila auriculata, &lt;/em&gt;belonging to the family Acanthaceae, is a promising medicinal plant with great economic potential. The medicinal value of &lt;em&gt;H. auriculata&lt;/em&gt; has been appreciated in the ancient medical literature. The plant contains terpenoids, alkaloids, flavonoids, and is traditionally known as an aphrodisiac, renal tonic, and for its health-promoting properties. The plant is cultivated throughout India. However, systematic information on the different aspects of this species is not available. In this review, an attempt has been made to present this information.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1748</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;S Dhanalakshmi&lt;sup&gt;1,&lt;/sup&gt;*, N Harikrishnan&lt;sup&gt;2&lt;/sup&gt;, N Srinivasan&lt;sup&gt;3&lt;/sup&gt;, P Pandian&lt;sup&gt;4&lt;/sup&gt;, BA Tanisha&lt;sup&gt;5&lt;/sup&gt;, M Tharun Kumar&lt;sup&gt;5&lt;/sup&gt;, V Lokesh&lt;sup&gt;5&lt;/sup&gt;, N Yuvashri&lt;sup&gt;5&lt;/sup&gt;, S Supriya&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ),Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry &amp;amp; Analysis, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ),Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pharma buddy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ), Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Krasikova MK</style></author><author><style face="normal" font="default" size="100%">Sergunova EV</style></author><author><style face="normal" font="default" size="100%">Bobkova NV</style></author><author><style face="normal" font="default" size="100%">Kovaleva TYu</style></author><author><style face="normal" font="default" size="100%">Bondar AA</style></author><author><style face="normal" font="default" size="100%">Marakhova AI</style></author><author><style face="normal" font="default" size="100%">Morokhina SL</style></author><author><style face="normal" font="default" size="100%">Krasnyuk II</style></author><author><style face="normal" font="default" size="100%">Moiseev DV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic, Phytochemical and Ethnopharmacological Potential of Cyclamen coum Mill</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Coumoside A</style></keyword><keyword><style  face="normal" font="default" size="100%">Coumoside B</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclacumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclamen coum</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclaminorin</style></keyword><keyword><style  face="normal" font="default" size="100%">Deglucocyclamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">204-212</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; This review focuses on characterization of &lt;em&gt;Cyclamen coum &lt;/em&gt;Mill. (&lt;em&gt;Myrsinaceae&lt;/em&gt;), composition and content of biologically active substances presented in the above-ground and underground parts, reporting use of this plant in traditional medicine, predicting possible pharmacotherapeutic effects. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Various electronic search engines such as Google, Google scholar, scientific literature, electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Cyclamen &lt;/em&gt;L. is classified in the &lt;em&gt;Myrsinaceae&lt;/em&gt; family now. It is a typical element of the Mediterranean flora. C. coum. is a species characteristic of the Caucasus and Crimea with rounded leaves and rounded corolla lobes, bright and pink-purple flowers. Chemical composition of biologically active substances of&lt;em&gt; C. coum&lt;/em&gt; was described in sufficient detail. &lt;em&gt;C. coum&lt;/em&gt; contains saponins (coumoside A, coumoside B, cyclaminorin, deglucocyclamin, cyclacoumin, and mirabilin lactone), sterols (stigmasterol and other related compounds), piperidine alkaloid (2-β-D-glycopyranosyl-2-undecil-3,5-dihydroxy-6-carboxypiperidine), flavonoids, phenols, tannins, cardiac glycosides. Antioxidant, antibacterial, antifungal, and antitumor activities are established for different &lt;em&gt;C. coum&lt;/em&gt; extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;C. coum &lt;/em&gt;can be used for the production of potential anticancer, antibacterial and antifungal drugs. It should be noted that more pharmacognostic, pharmacological studies are needed for providing further information to use this medicinal plant in the official medicine. Also, standardization procedures for a crude herbal drug should be developed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bokov DO&lt;sup&gt;1,2,&lt;/sup&gt;*,#, Krasikova MK&lt;sup&gt;1,&lt;/sup&gt;#, Sergunova EV&lt;sup&gt;1&lt;/sup&gt;, Bobkova NV&lt;sup&gt;1&lt;/sup&gt;, Kovaleva TYu&lt;sup&gt;1&lt;/sup&gt;, Bondar AA&lt;sup&gt;1&lt;/sup&gt;, Marakhova AI&lt;sup&gt;3&lt;/sup&gt;, Morokhina SL&lt;sup&gt;4&lt;/sup&gt;, Krasnyuk II&lt;sup&gt;1&lt;/sup&gt;, Moiseev DV&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Chemistry, Federal Research Center for Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Biochemical Technology and Nanotechnology, Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Preparatory faculty, Financial University under the Government of the Russian Federation (Financial University), 55, Leningradsky Prospekt, Moscow, 125057, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Chair of Standardization of Medicines, Vitebsk State Medical University, 27, Frunze avenue, Vitebsk, 210062, BELARUS #Bokov DO, Krasikova MK contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Karabeshkin DI</style></author><author><style face="normal" font="default" size="100%">Samylina IA</style></author><author><style face="normal" font="default" size="100%">Potanina OG</style></author><author><style face="normal" font="default" size="100%">Krasnyuk II</style></author><author><style face="normal" font="default" size="100%">Malinkin AD</style></author><author><style face="normal" font="default" size="100%">Sergunova EV</style></author><author><style face="normal" font="default" size="100%">Kovaleva TYu</style></author><author><style face="normal" font="default" size="100%">Bobkova NV</style></author><author><style face="normal" font="default" size="100%">Antsyshkina AM</style></author><author><style face="normal" font="default" size="100%">Bondar AA</style></author><author><style face="normal" font="default" size="100%">Evgrafov AA</style></author><author><style face="normal" font="default" size="100%">Galiakhmetova EK</style></author><author><style face="normal" font="default" size="100%">Moiseev DV</style></author><author><style face="normal" font="default" size="100%">Bessonov VV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacopoeial Analysis of Inulin-Containing Medicinal Plant Raw Materials and Drugs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fructosans</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-RID</style></keyword><keyword><style  face="normal" font="default" size="100%">Inulin quantitative determination</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyfructans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">415-421</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Today, there are some unresolved issues and discussions concerning inulin quantitative determination in medicinal plant raw materials (MPRM). MPRM containing polyfructans or fructosans (inulin and others) are rather complex multicomponent matrixes with many interacting compounds. The article discusses the prospects for further standardization of inulin-containing pharmacopoeial MPRM that include, in addition to polysaccharides (inulin), other biologically active compounds with pharmacological activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Different types of search tools such as Google scholar, Google, scientific literature, normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed had been searched and data obtained. &lt;strong&gt;Results: &lt;/strong&gt;The pharmacopoeial spectrophotometric procedures of inulin determination in the Russian Federation are approved in a version that does not fully satisfy modern standardization criteria. Regulatory changes required in the near future. &lt;strong&gt;Conclusion: &lt;/strong&gt;Undoubtedly, to determine inulin quantitatively, it is necessary to modify the existing spectrophotometric procedures and introduce an additional alternative, more specific HPLC-RID (or similar) ones.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">415</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bokov DO1,2,&lt;sup&gt;*,#&lt;/sup&gt;, Karabeshkin DI&lt;sup&gt;3,#&lt;/sup&gt;, Samylina IA&lt;sup&gt;1&lt;/sup&gt;, Potanina OG&lt;sup&gt;4&lt;/sup&gt;, Krasnyuk II&lt;sup&gt;1&lt;/sup&gt; (junior), Malinkin AD&lt;sup&gt;2&lt;/sup&gt;, Sergunova EV&lt;sup&gt;1&lt;/sup&gt;, Kovaleva TYu&lt;sup&gt;1&lt;/sup&gt;, Bobkova NV&lt;sup&gt;1&lt;/sup&gt;, Antsyshkina AM&lt;sup&gt;1&lt;/sup&gt;, Bondar AA&lt;sup&gt;1&lt;/sup&gt;, Evgrafov AA&lt;sup&gt;1&lt;/sup&gt;, Galiakhmetova EK&lt;sup&gt;5&lt;/sup&gt;, Moiseev DV&lt;sup&gt;6&lt;/sup&gt;, Bessonov VV&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Normal physiology department, Northern State Medical University, 51Troitsky pr., 163000, Arkhangelsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutical chemistry and pharmacognosy chair, Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacognosy with a course in botany and the basics of herbal medicine, Bashkir state medical University, 3, Lenina str., Ufa, 450008, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Chair of Standardization of Medicines, Vitebsk State Medical University, 27, Frunze avenue, Vitebsk, 210062, BELARUS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;Contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saybel OL</style></author><author><style face="normal" font="default" size="100%">Rendyuk TD</style></author><author><style face="normal" font="default" size="100%">Dargaeva TD</style></author><author><style face="normal" font="default" size="100%">Nikolaev SM</style></author><author><style face="normal" font="default" size="100%">Khobrakova VB</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic Compounds and Immunomodulating Activity of Chicory (Cichorium intybus L.) Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chicory herb</style></keyword><keyword><style  face="normal" font="default" size="100%">Dry extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulating activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1104-1107</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This research aims to determine the immunomodulating activity of chicory (&lt;em&gt;Cichorium intybus&lt;/em&gt; L.) herb extract and to evaluate the prospects of development of the medicine based on it. &lt;strong&gt;Methods:&lt;/strong&gt; Object of the research was dry chicory extract obtained from herb (aerial part) of a wild plant. The chemical composition of the extract was determined by HPLC-MS method. Its immunomodulating action has been explored &lt;em&gt;in vivo &lt;/em&gt;experiments involving intact animals, as well as immunosuppressed animals, treated with azathioprine cytostatic agent. Chicory extract was administered at a dose of 30 mg/kg per os 1 time per day for 14 days. As a reference drug, Immunal (Lec Pharma, Slovenia) was used. Chicory extract action on the state of cell immune component was evaluated in delayed hypersensitivity reaction. The humoral immunity condition was evaluated by the count of antibody-forming cells determined by the local hemolysis method. The state of the macrophage component of the immune response was evaluated in the phagocytosis reaction of peritoneal macrophages in relation to colloid liquid ink particles. &lt;strong&gt;Results:&lt;/strong&gt; Dry chicory extract is capable to reduce the suppressive azathioprine effect on the cell-mediated immune response, antibody response, and phagocytosis with macrophages; it does not change the immunity indicators in intact animals. &lt;strong&gt;Conclusion: &lt;/strong&gt;Dry chicory extract contains phenolic complex of biologically active substances, namely oxycoumarins, hydroxycinnamic acids, and flavonoids. Dry chicory extract is an effective immunocorrecting agent; it should be recommended for further study and application aiming for the prevention and treatment of immunodeficiency states.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1104</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Saybel OL&lt;sup&gt;1,&lt;/sup&gt;*, Rendyuk TD&lt;sup&gt;2&lt;/sup&gt;, Dargaeva TD&lt;sup&gt;1&lt;/sup&gt;, Nikolaev SM&lt;sup&gt;3&lt;/sup&gt;, Khobrakova VB&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;FSBSI All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;FPFIS Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asmaa S Abd Elkarim</style></author><author><style face="normal" font="default" size="100%">Sahar Abdelaziz</style></author><author><style face="normal" font="default" size="100%">Hany Gouda Attia</style></author><author><style face="normal" font="default" size="100%">Hanan AA Taie</style></author><author><style face="normal" font="default" size="100%">Rafik Monir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Antioxidant Evaluation of the Flavonoids and Tannins from Synadenium grantii Hook f, (Ephorbiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ephorbiaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Synadenium grantii</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1421-1428</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The methanol extract (MeE) of the aerial parts from &lt;em&gt;Synadenium grantii &lt;/em&gt;Hook f, (Ephorbiaceae) has more Polyphenols and used to treat several diseases. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study is isolation, purification and identification of Polyphenols that showed good antioxidant activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study, purification of the MeOH-H&lt;sub&gt;2&lt;/sub&gt;O extract (70:30) from the air-dried aerial parts of &lt;em&gt;S. grantii &lt;/em&gt;resulted by different chromatographic tools. The antioxidant activities were evaluated for the examined compounds by several methods using DPPH, Reducing power, ABTS and FRAP assays. &lt;strong&gt;Results:&lt;/strong&gt; A total of&lt;strong&gt; 14 &lt;/strong&gt;compounds were isolated from this plant species for the first time. The results obtained showed that all the examined compounds possess remarkable antioxidant activity through all assays especially compounds &lt;strong&gt;2&lt;/strong&gt; and &lt;strong&gt;4&lt;/strong&gt; where they showed the highest antioxidant activity among the other compounds and very close to the results of the standard compound BHA. &lt;strong&gt;Conclusion: &lt;/strong&gt;The compounds examined have exhibited antioxidant activity with promising value as natural source antioxidant drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1421</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Asmaa S. Abd Elkarim&lt;sup&gt;1,&lt;/sup&gt;*, Sahar Abdelaziz&lt;sup&gt;2&lt;/sup&gt;, Hany Gouda Attia&lt;sup&gt;3,4&lt;/sup&gt;, Hanan A.A. Taie&lt;sup&gt;5&lt;/sup&gt;, Rafik Monir&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki-Giza-P.O.12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy department, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of pharmacognosy, faculty of pharmacy, Najran University, Najran 55461, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of pharmacognosy, faculty of pharmacy, Kafr EL- Shiekh university, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Plant Biochemistry Department, Division of Agriculture and Biological Researches, National Research Centre, 33 El-Bohouth St. (Former El-Tahrir St.), Dokki 12622, Giza, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacogonosy department, Faculty of Pharmaceutical sciences and drug manufacturing, Misr University for Science and Technology, 6th October City, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Vincent Kharisma Wangsaputra</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Wilzar Fachri</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author><author><style face="normal" font="default" size="100%">Hiroki Tanimoto</style></author><author><style face="normal" font="default" size="100%">Kiyomi Kakiuchi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Composition and Evaluation of Marine Algal Sargassum polycystum for Antioxidant Activity and In Vitro Cytotoxicity on Hela Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">phytochemisty</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum polycystum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">88-94</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Sargassum polycystum&lt;/em&gt; is one of marine algal which has a potent antioxidant anticancer activities. This research aims to investigate phytochemical composition, antioxidant activity and &lt;em&gt;in vitro &lt;/em&gt;cytotoxicity of marine algal &lt;em&gt;Sargassum polycystum &lt;/em&gt;on cervical HeLa cancer.&lt;strong&gt; Methods:&lt;/strong&gt; &lt;em&gt;Sargassum polycystum&lt;/em&gt; collected from Dompu beach, Lombok, Nusa Tenggara Barat Province, Indonesia, were extracted into organic solvent of n-hexane, ethylacetate, chloroform and ethanol, respectively. Subsequently, &lt;em&gt;Sargassum polycystum&lt;/em&gt; extracts were applied for Thin Layer Chromatography (TLC) analysis, phytochemistry test, total phenolic and total flavonoid contents, as well as for antioxidant activity test by DPPH (2,2-diphenyl-1-picrylhydrazyl) method, and in vitro cytotoxicity evaluation on HeLa cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide) assay. &lt;strong&gt;Results: &lt;/strong&gt;Phytochemical analysis of&lt;em&gt; S. polycystum&lt;/em&gt; extracts are positive for metabolites of flavonoid, steroid, tannin and glycoside. TLC analysis revealed that &lt;em&gt;S. polycystum&lt;/em&gt; extracts containing four phytochemical components. Ethylacetate extract of&lt;em&gt; S. polycystum&lt;/em&gt; showed the highest total phenolic content, and exhibited greater antioxidant activity than ethanol extract. Total phenolic and total flavonoid content in ethylacetate extract are 548.61 μg/mL and 40.06 μg /mL, respectively. Ethylacetate extract of &lt;em&gt;S. polycystum&lt;/em&gt; with IC&lt;sub&gt;50&lt;/sub&gt; value of 298.3 μg/mL is assigned to have a weak antioxidant activity against DPPH free radical. The results indicate that antioxidant activity of ethylacetate extracts of &lt;em&gt;S. polycystum&lt;/em&gt; is directly correlated with its total phenolic and flavonoid content. Moreover, &lt;em&gt;S. polycystum&lt;/em&gt; extracts demonstrated a strong anticancer activity on cervical HeLa cells with IC&lt;sub&gt;50 &lt;/sub&gt;ranging from 38.3 μg/mL to 112.8 μg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; This work confirmed that S.polycystum are promising natural antioxidant and anti-cervical cancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">88</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Anton Bahtiar&lt;sup&gt;3&lt;/sup&gt;, Vincent Kharisma Wangsaputra&lt;sup&gt;4&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Wilzar Fachri&lt;sup&gt;5,2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin1, Hiroki Tanimoto&lt;sup&gt;6&lt;/sup&gt;, Kiyomi Kakiuchi&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Gerry Kurniawan</style></author><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Profile, Antioxidant Activity and Cell Line Study of Marine Red Macroalgae Eucheuma cottonii on Lung A-549 Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell line study</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucheuma cottonii</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung A-549 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">276-281</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;In this century, cancer has increased in incidence and become one of the deadliest disease in the world. However, to date, lung cancer treatments are still not fully effective, quite expensive and very exhaustive for the patient. &lt;em&gt;Eucheuma cottonii&lt;/em&gt; is an abundant marine red macroalgae in Indonesia which have a potential anti-lung cancer properties. Aim of this research is to determine phytochemical profile of &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extracts, as well as to evaluate its antioxidant and cytotoxic effects on Lung A-549 cancer cells.&lt;strong&gt; Methods:&lt;/strong&gt; &lt;em&gt;Eucheuma cottonii&lt;/em&gt; obtained from Sorong beach, West Papua Province, Indonesia, were extracted with three different solvents, that is ethanol, ethylacetate, and n-hexane. These three &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extracts were identified for its phytochemical profiles, antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, and cytotoxic activity on lung A-549 cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis revealed that &lt;em&gt;Eucheuma cottonii&lt;/em&gt; contains metabolites of triterpenoid and alkaloid. Antioxidant activity evaluation showed ethanol extract of &lt;em&gt;Eucheuma cottonii &lt;/em&gt;has IC&lt;sub&gt;50&lt;/sub&gt; value of 559.76 μg/mL against DPPH free radical. Whereas cytotoxicity evaluation showed that ethanol extract and ethylacetate extract of &lt;em&gt;Eucheuma cottonii&lt;/em&gt; have cytotoxic effects on Lung A-549 cancer cells, with IC&lt;sub&gt;50 &lt;/sub&gt;value of 251.73 μg/ mL and 261.41 μg/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggesting that &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extract could be further developed as a natural anti-lung cancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Gerry Kurniawan&lt;sup&gt;3&lt;/sup&gt;, Nadzila Anindya Tejaputri&lt;sup&gt;3&lt;/sup&gt;, Fona Qorina&lt;sup&gt;3&lt;/sup&gt;, Qotrunnada Fithrotunnisa&lt;sup&gt;3&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Joni Tandi</style></author><author><style face="normal" font="default" size="100%">I Nyoman Edi Sutrisna</style></author><author><style face="normal" font="default" size="100%">Mentari Pratiwi</style></author><author><style face="normal" font="default" size="100%">Tien Wahyu Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Test of Nephropathy Sonchus arvensis L. Leaves on Male Rats (Rattus norvegicus) Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf Sonchus arvensis L</style></keyword><keyword><style  face="normal" font="default" size="100%">Renal</style></keyword><keyword><style  face="normal" font="default" size="100%">Tubular</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1115-1120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to determine the type of secondary metabolites compounds of the ethanol&lt;em&gt; Sonchus arvensis&amp;nbsp;&lt;/em&gt;L leaves extract, the effect of ethanol &lt;em&gt;Sonchus arvensis&lt;/em&gt; L leaves extracts the levels of blood glucose and a histopathology picture male white rat induced by streptozotocin. This study used 30 males white rats which were divided into 6 groups, namely the control of normal, negative control, positive control, doses of 200, 300 and 400 mg/kg BW. Results of the study showed that the ethanol &lt;em&gt;Sonchus arvensis&lt;/em&gt; L. leaves extracts contained compounds of alkaloids, flavonoids, phenols, saponins and tannins. &lt;em&gt;Sonchus arvensis&lt;/em&gt; L ethanol extract at a dose of 300 mg/kg BW is an effective dose in reducing blood glucose levels with an average value of decreasing blood glucose levels 101.6 mg / dL and has an effect on the regeneration of renal tubular cells with an effective dose is 300 mg / kg body weight with an average damage value of 0.28.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1115</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Joni Tandi*, I Nyoman Edi Sutrisna, Mentari Pratiwi, Tien Wahyu Handayani &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;College of pharmaceutical sciences Pelita Mas Palu, Central Sulawesi 94111, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">M Devi</style></author><author><style face="normal" font="default" size="100%">S Dhanalakshmi</style></author><author><style face="normal" font="default" size="100%">GE Thillai Govindarajan</style></author><author><style face="normal" font="default" size="100%">BA Tanisha</style></author><author><style face="normal" font="default" size="100%">Talluri Sonalika</style></author><author><style face="normal" font="default" size="100%">JE Ruth</style></author><author><style face="normal" font="default" size="100%">T Avinash</style></author><author><style face="normal" font="default" size="100%">C Jethendra Sri</style></author><author><style face="normal" font="default" size="100%">K Logeswaran</style></author><author><style face="normal" font="default" size="100%">M Nithish Ramasamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review on Phaseolus vulgaris Linn</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Food crop</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phaseolus vulgaris Linn</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1160-1164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal herbs have been discovered and used in traditional medicine practices since antiquated times. &lt;em&gt;Phaseolus vulgaris&lt;/em&gt; Linn. (Family-Fabaceae) commonly known as French bean, is a most consuming carbohydrate and protein rich food crop having medicinal values. This plant having diverse compounds like carbohydrate, proteins, flavonoids, Saponins, tannins and phenolic acid. The seeds of&lt;em&gt; Phaseolus vulgaris &lt;/em&gt;Linn. Possess having anti-urolithiatic activity and anti- obesity activity. This review provides a summary of phytochemistry and pharmacological effect of &lt;em&gt;Phaseolus vulgaris &lt;/em&gt;Linn., The plant can be further investigated for other pharmacological activities as it contains variety of chemical constituents and it is a commonly using food crop and medical remedies of this plant are sync with nature.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1160</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;M Devi&lt;sup&gt;1&lt;/sup&gt;,*, S Dhanalakshmi&lt;sup&gt;2&lt;/sup&gt;, GE Thillai Govindarajan&lt;sup&gt;3&lt;/sup&gt;, BA Tanisha&lt;sup&gt;3&lt;/sup&gt;, Talluri Sonalika&lt;sup&gt;3&lt;/sup&gt;, JE Ruth&lt;sup&gt;3&lt;/sup&gt;, T Avinash&lt;sup&gt;3&lt;/sup&gt;, C Jethendra Sri&lt;sup&gt;3&lt;/sup&gt;, K Logeswaran&lt;sup&gt;3&lt;/sup&gt;, M Nithish Ramasamy&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi 600 077, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi 600 077, Chennai, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Pharma Buddy, Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Velappanchavadi 600 077, Chennai, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shikha Dixit</style></author><author><style face="normal" font="default" size="100%">Sugandha Tiwari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review on Plants for Management of Diabetes in India: An Ethno- Botanical and Pharmacological Perspective</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes management</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnopharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">India</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1801-1810</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus is a prevalent chronic disease, which is recognized as a common threat to health in the last decade, especially in Asia. It is a lifestyle disease which may cause a number of complications in the body of humans like cardiac failure and dysfunctioning of urinary tract. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The data is obtained from various search tools and electronic databases like, scientific literature, Google scholar, Google, Pubmed, Web of science and Scopus. &lt;strong&gt;Results: &lt;/strong&gt;Major therapy for diabetes is insulin, oralantidiabetic drugs, and herbal treatment. However, insulin and oral anti-diabetic drugs come with a number of side effects and cannot be afforded by people with below poverty line. The herbal medicines have performed a satisfactory clinical practice for the management of diabetes mellitus. Moreover, pharmacological &amp;amp; phytochemical screening of medicinal plants has also witnessed the hypoglycaemic effects of these plants in treating diabetes mellitus. Majority of the modern drugs like metformin, atropine, digitalis, etc. are also originated from plants. &lt;strong&gt;Conclusion: &lt;/strong&gt;The current paper presents a review of medicinal plants used for diabetes management in India. The therapeutic potential, ethnobotanical use, and their pharmacological evaluations are highlighted for harnessing the anti-diabetic potential of these plants by the Indian healthcare system.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1801</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shikha Dixit*, Sugandha Tiwari &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Botany, DGPG College, CSJMU Kanpur, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Vincent Kharisma Wangsaputra</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author><author><style face="normal" font="default" size="100%">Hiroki Tanimoto</style></author><author><style face="normal" font="default" size="100%">Kiyomi Kakiuchi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis, Characterization, and Cytotoxicity Evaluation of Gallic Acid Nanoparticles Towards Breast T47D Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">321-327</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Gallic acid is a naturally polyphenolic acid which shows cytotoxicity against several cancer cells, as well as it displays chemo-preventive activity which is attributed to its strong apoptosis- inducing and antioxidant effects. Thus, gallic acid has become an attractive substance to be further developed due to its strong cytotoxic activity. This study aimed to synthesize gallic acid nanoparticle coating with alginate-chitosan, and evaluate its cytotoxicity against breast T47D cancer cells.&lt;strong&gt; Methods: &lt;/strong&gt;Gallic acid nanoparticle was synthesized using ionic gelation method. The yield, size and morphology of the nanoparticles were determined by UV-Vis Spectroscopy, Transmission electron microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. Cytotoxicity evaluation of gallic acid nanoparticle towards breast T47D cancer cell is carried out by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Spherical nanoparticles of gallic acid with the size of 100-200 nm has been successfully synthesized in 96% of yield. Compared to gallic acid (IC&lt;sub&gt;50&lt;/sub&gt;: 20.86 μg/mL) and alginate-chitosan nanoparticle (IC&lt;sub&gt;50&lt;/sub&gt;: 38.46 μg/mL), gallic acid coating with alginate-chitosan nanoparticles demonstrated higher cytotoxicity towards breast T47D cancer cells with IC&lt;sub&gt;50 &lt;/sub&gt;value of 9.03μg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results clearly confirmed that gallic acid nanoparticles coating with alginate-chitosan showed a strong cytotoxicity towards breast T47D cancer cells, which is potential to be developed as a candidate for new anti-breast cancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">321</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Anton Bahtiar&lt;sup&gt;3&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,2&lt;/sup&gt;, Vincent Kharisma Wangsaputra&lt;sup&gt;4&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt;, Hiroki Tanimoto&lt;sup&gt;5&lt;/sup&gt;, Kiyomi Kakiuchi&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Van Anh T Nguyen</style></author><author><style face="normal" font="default" size="100%">Thang Viet Le</style></author><author><style face="normal" font="default" size="100%">Manh Van Bui</style></author><author><style face="normal" font="default" size="100%">Toan Quoc Pham</style></author><author><style face="normal" font="default" size="100%">Son The Trinh</style></author><author><style face="normal" font="default" size="100%">Binh Nhu Do</style></author><author><style face="normal" font="default" size="100%">Lien Huong T Nguyen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tacrolimus Therapeutic Drug Monitoring in Vietnamese Renal Transplant Recipients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Renal transplantation</style></keyword><keyword><style  face="normal" font="default" size="100%">Tacrolimus</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutic drug monitoring</style></keyword><keyword><style  face="normal" font="default" size="100%">Vietnam</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">984-992</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Use of tacrolimus (Tac) is pivotal to renal transplant (RT) immunosuppressive maintenance regiments. The most frequently used means of Tac monitoring is the measurement of the trough concentration (C0) in whole blood to maintain drug efficacy and minimize the consequences of overexposure. Most previous studies focused on therapeutic drug monitoring of Tac in renal transplant recipients and assessed the clinical response of patients. Our study aimed to describe a real Tacrolimus therapeutic drug monitoring transplantation and determine the clinical outcomes in Vietnamese adult renal transplant recipients. &lt;strong&gt;Methods: &lt;/strong&gt;This retrospective study including 114 adult renal transplant patients (89 men and 25 women) with a mean age of 35.4 ± 8.98 years has been performed from August 2012 to March 2018 at Military Hospital 103 (Vietnam). Tac trough concentrations were adjusted according to the target range proposed by the European consensus conference on tacrolimus optimization. Samples for determination of tacrolimus blood levels were subdivided according to the posttransplantation period into three groups (0- 3 months (G1), 3-12 months (G2) and over 1 year (G3). Median Years of follow-up was 15.4 months [range 0.233 to 68.4 months]. &lt;strong&gt;Results:&lt;/strong&gt; A total of 3037 blood samples for the determination of tacrolimus trough concentration were obtained. Median concentrations were 6.7 (4.5 – 10.2) ng/ml, 6.4 (5.1 – 8.3) and 5.6 (4.5 to 7.1) ng/ml for G1, G2, G3, respectively. After transplantation, three acute rejection (AR) events were documented (Cellular AR: 2, Humoral AR: 1). Cytomegalovirus, BK polyomavirus, Hepatitis B virus and Hepatitis C virus were detected in 7, 4, 7 and 3 renal post- transplant recipients, respectively. There were 5 patients with post-transplant diabetes (NODAT) and all of them had to convert to cyclosporine. 6 patients developed chronic kidney disease (CKD) after transplantation and 2 case with Tac-associated nephrotoxicity with proven biopsy. This observational study provided a real Tacrolimus therapeutic drug monitoring transplantation in Vietnamese renal transplant recipients. Main outcomes were acute rejection, post-transplant viral infections, neurotoxicity, NODAT, CKD, and Tac-associated nephrotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">984</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Van Anh T. Nguyen&lt;sup&gt;1,4,6&lt;/sup&gt;, Thang Viet Le&lt;sup&gt;2,6&lt;/sup&gt;, Manh Van Bui&lt;sup&gt;3,6,&lt;/sup&gt;*, Toan Quoc Pham&lt;sup&gt;2,6&lt;/sup&gt;, Son The Trinh&lt;sup&gt;6&lt;/sup&gt;, Binh Nhu Do&lt;sup&gt;5,6&lt;/sup&gt;, Lien Huong T. Nguyen&lt;sup&gt;4,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Military Hospital 103, Ha Dong, Ha Noi 121-08, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Renal and Haemodialysis, Military hospital 103, Ha Dong, Ha Noi 121- 08, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center for Emergency Medicine, Intensive Care and Toxicology control, Military hospital 103, Ha Dong, Ha Noi 121-08, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pharmacy, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Ha Noi 110-19, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Military Science, Military Hospital 103, Ha Dong, Ha Noi 121-08, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Vietnam Military Medical University, Ha Dong, Ha Noi 121-08, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">G Tharun</style></author><author><style face="normal" font="default" size="100%">S Sivakrishnan</style></author><author><style face="normal" font="default" size="100%">JVC Sharma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toxicity Assessment, Evaluation of Antioxidant and Hepatoprotective Activity on Cordia obliqua Fruit Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cordia obliqua</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1005-1011</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cordia obliqua &lt;/em&gt;Willd plant is a genus of flowering plants in the borage family, Boraginaceae. It is also known as clammy cherry. Very little research was carried out for identification of its medicinal importance when compared to other Cordia species&lt;strong&gt; Objective: &lt;/strong&gt;To determine the safe dose and to explore the in vivo antioxidant and hepatoprotective activity of &lt;em&gt;Cordia obliqua &lt;/em&gt;fruits &lt;strong&gt;Methods:&lt;/strong&gt; As per our previous study the ethanolic and aqueous extracts were rich in phytoconstituents and exhibited good in vitro antioxidant effect. So the ethanolic and aqueous extracts were used for evaluation of activity. Acute toxicity study (LD&lt;sub&gt;50&lt;/sub&gt;) was conducted according to OECD guidelines. For hepatoprotective activity paracetamol induced hepatotoxicity was studied using standard drug like Silymarin. The antioxidant potential] of the plant extracts were tested using three tests viz, Reduced GSH, Catalase and SOD activity &lt;strong&gt;Results: &lt;/strong&gt;Acute toxicity studies showed the non-toxic nature of &lt;em&gt;Cordia obliqua&lt;/em&gt; fruit extract upto dose of 3000mg/kg body weight. Administration of Paracetamol to rats increased the levels of marker enzymes like ALT, AST and ALP. Increase in the levels of these enzymes in serum indicates damage to the liver cells. Pretreatment with aqueous and ethanolic extracts of &lt;em&gt;Cordia obliqua &lt;/em&gt;decreased the levels of ALT, AST, ALP and increased levels of total protein, total bilirubin, direct bilirubin and comparisons histology of cells of extract which are an indication for the hepatoprotective activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;The fruits of &lt;em&gt;Cordia obliqua&lt;/em&gt; are safe and effective in treatment of hepatic disorders and prevent oxidation of cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1005</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;G Tharun&lt;sup&gt;1,&lt;/sup&gt;*, S Sivakrishnan&lt;sup&gt;2&lt;/sup&gt;, JVC Sharma&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PhD Research Scholar of Department of Pharmacy, Annamalai University, Chidambaram and Asst. Professor, University College of Pharmaceutical Sciences, Palamuru University, Mahabubnagar, Telangana, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Pharmacy, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamilnadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor and Principal, Joginpally B.R Pharmacy College, Yenkapally, Moinabad, R.R. Dist. Telangana, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adelina Simamora</style></author><author><style face="normal" font="default" size="100%">Kris Herawan Timotius</style></author><author><style face="normal" font="default" size="100%">Adit Widodo Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic, Antibacterial and Antioxidant Activities of Different Extracts from Brucea javanica (L.) Merr Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Additive inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Brucea javanica</style></keyword><keyword><style  face="normal" font="default" size="100%">Mixed type inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">479-485</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The seeds of &lt;em&gt;B. javanica&lt;/em&gt; are known as herbal material for anticancer, antimalaria and antiamoeba. Limited report is available on their antidiabetic and antibacterial properties. &lt;strong&gt;Methods:&lt;/strong&gt; Methanol (ME) and Ethyl acetate extracts (EAE) were studied for their inhibition activities on α-glucosidase &lt;em&gt;in vitro&lt;/em&gt;, including combination of ME with acarbose and inhibition mechanism. Antibacterial activity was tested by well diffusion and microdilution methods. The extracts were evaluated for their &lt;em&gt;in vitro&lt;/em&gt; antioxidant property by DPPH assay, as well as their phenolic and flavonoid contents. &lt;strong&gt;Results:&lt;/strong&gt; ME exhibited a strong α-glucosidase inhibition activity (IC&lt;sub&gt;50&lt;/sub&gt; 271.97 &lt;em&gt;μ&lt;/em&gt;g/ml) compared to EAE and acarbose (IC&lt;sub&gt;50&lt;/sub&gt; of 1745.05 and 823.99 &lt;em&gt;μ&lt;/em&gt;g/ml, respectively). A low dose of ME gave an additive inhibition on α-glucosidase when combined with acarbose. By a kinetic analysis, ME was found to inhibit α-glucosidase in a mixed-type inhibition. Both ME and EAE showed strong antibacterial activities against gram negative and positive bacteria. The strongest inhibition was observed against &lt;em&gt;C. violaceum&lt;/em&gt; and &lt;em&gt;S. mutans&lt;/em&gt; for ME (MIC of both 0.387 mg/ml) and &lt;em&gt;P. aeruginosa&lt;/em&gt; for EAE (MIC 2.938 mg/ml). Both extracts showed weaker antioxidant activities than standards; IC&lt;sub&gt;50&lt;/sub&gt; 664.73 and 4225.40 μg/ml, respectively. ME was rich in phenolics (277.54 mg GAE/100 g DW), unlike EAE (1.86 mg GAE/100 g DW). &lt;strong&gt;Conclusion:&lt;/strong&gt; This study can recommend &lt;em&gt;B. javanica&lt;/em&gt; seeds as a source for antidiabetic and antibacterial agents. Combination with acarbose may have important role for the treatment of diabetes mellitus.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">479</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Adelina Simamora&lt;sup&gt;1,*&lt;/sup&gt;, Kris Herawan Timotius&lt;sup&gt;1&lt;/sup&gt;, Adit Widodo Santoso&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Krida Wacana Christian University, Jakarta- 11510, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Herbal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jakarta- 11510, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Godishala Shirisha</style></author><author><style face="normal" font="default" size="100%">Kiranmai Mandava</style></author><author><style face="normal" font="default" size="100%">Uma Rajeswari Batchu</style></author><author><style face="normal" font="default" size="100%">Kesava Rao Thammana</style></author><author><style face="normal" font="default" size="100%">Vijaya Laxmi Turpu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antitumor and Antioxidant Effects of Flavonoid Fraction of Citrus sinensis peel Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dalton lymphoma ascites</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethidium bromide</style></keyword><keyword><style  face="normal" font="default" size="100%">Methotrexate</style></keyword><keyword><style  face="normal" font="default" size="100%">Orange peel flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Tryphan blue</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">57-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cancer is one of the leading causes of death and globally the numbers of cases of cancer are increasing gradually. However, surgeries, chemotherapies have become safer, but these treatments have debilitating side effects. Flavonoids present in the human diet comprise many polyphenolic secondary metabolites with broad-spectrum pharmacological activities including their potential role as anti-cancer agents. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study was to extract, orange peel flavonoids (Orange Peel Extract) and to screen anticancer potential of OPF. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study tryphan blue dye exclusion, clonogenic assay and nuclear damage studies by ethidium bromide staining were performed to estimate &lt;em&gt;in vitro&lt;/em&gt; antitumor properties of Orange Peel Extract and subsequently &lt;em&gt;in vivo&lt;/em&gt; studies also performed using the Dalton lymphoma ascites (DLA) tumor model in Swiss albino mice. &lt;strong&gt;Results:&lt;/strong&gt;&lt;em&gt; In vitro&lt;/em&gt; studies revealed the moderate toxicity, high regenerative capacity of Orange Peel Extract and also showed changes in nuclear morphology similar to that of apoptotic cells which is one of the important aspect of an anticancer drug. &lt;em&gt;In vivo&lt;/em&gt; studies confirmed the anticancer activity of Orange Peel Extract and has increased the average life span of treated animals and restored the antioxidant enzyme levels and hematological parameters to normal which was comparable to that of standard methotrexate. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, these findings have proved that out of the two doses (50mg/kg bw and 200mg/kg bw) employed for the study lower dose (50mg/kg) was found to be more effective than higher dose (200mg/ kg). Hence flavonoid fraction of orange peels can be the better alternative to treat cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">57</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Godishala Shirisha&lt;sup&gt;1&lt;/sup&gt;, Kiranmai Mandava&lt;sup&gt;*2&lt;/sup&gt;, Uma Rajeswari Batchu&lt;sup&gt;2&lt;/sup&gt;, Kesava Rao Thammana&lt;sup&gt;2&lt;/sup&gt;, Vijaya Laxmi Turpu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biotechnology, JSS College of Pharmacy, Ootacamund Tamil nadu 643001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Bharat Institute of Technology, Ranga Reddy District, Telangana 501510, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsayed Omer</style></author><author><style face="normal" font="default" size="100%">Abdelsamed Elshamy</style></author><author><style face="normal" font="default" size="100%">Rihab Taher</style></author><author><style face="normal" font="default" size="100%">Walaa El-Kashak</style></author><author><style face="normal" font="default" size="100%">Joseph Shalom</style></author><author><style face="normal" font="default" size="100%">Alan White</style></author><author><style face="normal" font="default" size="100%">Ian Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cakile maritima Scop. Extracts Inhibit Caco2 and HeLa Human Carcinoma Cell Growth: GC-MS Analysis of an Anti-Proliferative Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brassicaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">European searocket</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">258-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Exposure to high levels of antioxidants has been linked to the treatment and prevention of some cancers. Although &lt;em&gt;Cakile maritima&lt;/em&gt; has a high antioxidant capacity, it is yet to be tested for the ability to inhibit the proliferation of cancer cells. &lt;strong&gt;Methods&lt;/strong&gt;: Solvent extracts prepared from &lt;em&gt;C. maritima&lt;/em&gt; plant material were analysed for antioxidant capacity by the DPPH free radical scavenging assay. Anti-proliferative activities against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cells were determined by an MTS based cell proliferation assay. Toxicity was determined by the Artemia franciscana bioassay. The most potent anti-proliferative extract (hexane) was further investigated using non-targeted GC-MS headspace analysis. &lt;strong&gt;Results&lt;/strong&gt;: Good DPPH radical scavenging activity was calculated for all &lt;em&gt;C. maritima&lt;/em&gt; extracts. The methanolic and ethyl acetate extracts had particularly strong antioxidant activity (IC&lt;sub&gt;50&lt;/sub&gt; of 4.7 and 3.4 μg/mL respectively). Interestingly, the hexane extract which had the lowest DPPH radical scavenging activity (IC&lt;sub&gt;50&lt;/sub&gt; 13.6 μg/mL), was the most potent inhibitor or Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa carcinoma cell growth, with IC&lt;sub&gt;50&lt;/sub&gt;’s of 12 and 126 μg/mL respectively. The ethyl acetate extract was also a potent inhibitor of proliferation (IC&lt;sub&gt;50&lt;/sub&gt; values of 185 and 468 μg/mL against Caco&lt;sub&gt;2&lt;/sub&gt; and HeLa, respectively). The methanolic extract (IC&lt;sub&gt;50&lt;/sub&gt; values of 2261 and 2046 μg/mL against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa respectively) displayed only moderate anti-proliferative activity, demonstrating that antioxidant activity did not correspond with anti-proliferative activity. All of the extracts were determined to be nontoxic in the Artemia franciscana bioassay, with LC&lt;sub&gt;50&lt;/sub&gt; values substantially &amp;gt;1000 μg/mL. Non-biased GC-MS headspace analysis of the &lt;em&gt;C. maritima&lt;/em&gt; hexane extract highlighted several interesting compounds that may contribute to the therapeutic bioactivities of the extract. &lt;strong&gt;Conclusion&lt;/strong&gt;: The lack of toxicity and the anti-proliferative activity of the hexane and ethyl acetate &lt;em&gt;C. maritima &lt;/em&gt; extracts against HeLa and Caco&lt;sub&gt;2&lt;/sub&gt; cancer cell lines indicates their potential in the treatment and prevention of some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">258</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Elsayed Omer&lt;sup&gt;1&lt;/sup&gt;, Abdelsamed Elshamy&lt;sup&gt;2&lt;/sup&gt;, Rihab Taher&lt;sup&gt;2&lt;/sup&gt;, Walaa El- Kashak&lt;sup&gt;2&lt;/sup&gt;, Joseph Shalom&lt;sup&gt;3,4&lt;/sup&gt;, Alan White&lt;sup&gt;4&lt;/sup&gt;, Ian Cock&lt;sup&gt;3,4* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal and Aromatic Plants Research , National Research Centre, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry and Natural Compounds, National Research Centre, Dokki, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Loi Vu Duc</style></author><author><style face="normal" font="default" size="100%">Xuan Bui Thi</style></author><author><style face="normal" font="default" size="100%">Ngoc Tran Minh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Constituents and Anti-Ulcer Activity of Ethylacetate Extract of the Leaves of Sanchezia nobilis Hook.F.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-ulcer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sanchezia nobilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Scopoletin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1172-1180</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Study have two objectives. First objective is about the identification of the five components. The second objective is about the antiulcer activity of the ethylacetate extract. Five compounds (1–5) were isolated from the leaves of &lt;em&gt;Sanchezia nobilis &lt;/em&gt;Hook.F. collected in Nam Dinh province by chromatographic methods. These compounds were identified as: Quercetin &lt;strong&gt;(1)&lt;/strong&gt;, Scopoletin &lt;strong&gt;(2)&lt;/strong&gt;, Kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside &lt;strong&gt;(3)&lt;/strong&gt;, Quercetin-3-O-α-L-rhamnosyl-(1→6)-β-D-glucopyranosyl-(1→3)-β-D-glucopyranoside &lt;strong&gt;(4)&lt;/strong&gt;,3’-Omethyl- 3,4-methylenedioxy ellagic acid &lt;strong&gt;(5)&lt;/strong&gt;.Their structures were elucidated by spectroscopic methods, including mass spectrometry (MS) and nuclear magnetic resonance (NMR). Compounds &lt;strong&gt;3, 4, 5&lt;/strong&gt; were isolated from the leaves of &lt;em&gt;Sanchezia nobilis &lt;/em&gt;Hook.F. for the first time. Evaluation the effect of gastric and duodenal anti-ulcer on cyteamine induced gastric ulcer models indicates at this ethylacetate extract has the effect to improve the extent of ulcer lesions treatment (54,17 %); obviously reduced the average of number pocket of ulcers (1,85 ± 0,80) and ulcer index (5,61 ± 2,69), however, it does not change the area of the ulcer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1172</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Loi Vu Duc&lt;sup&gt;1&lt;/sup&gt;,* , Xuan Bui Thi&lt;sup&gt;1&lt;/sup&gt;, Ngoc Tran Minh&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Medicine and Pharmacy, Viet nam National University, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;National Institute of Medicinal Materials, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Nurrashida Binti Mok Hallim</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Anwar Ibrahim</style></author><author><style face="normal" font="default" size="100%">Salinah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between the Effect of Precipitate and Supernatant Aloe vera Gel on Experimental Cutaneous Wound Healing Using Optical Coherence Tomography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aloe vera</style></keyword><keyword><style  face="normal" font="default" size="100%">OCT</style></keyword><keyword><style  face="normal" font="default" size="100%">Precipitate</style></keyword><keyword><style  face="normal" font="default" size="100%">Supernatant</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">405-412</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Wound healing is a fundamental response to injured tissue that results in the restoration of tissue integrity. One of the famous herbs that promote wound healing is &lt;em&gt;Aloe vera&lt;/em&gt;. Despite well known for its therapeutic effect, several studies reported inconclusive evidence regarding this. Besides, lack of evidence to postulate the superior effect of two components of Aloe vera which are the precipitate and supernatant. &lt;strong&gt;Objective:&lt;/strong&gt; Study compares the effects of precipitate and supernatant in promoting tissue repair. Evaluation takes place by using optical Coherence Tomography (OCT) and is comparable with histopathology study. &lt;strong&gt;Methods:&lt;/strong&gt; Twelve male mice were randomly divided into four groups (precipitate, supernatant, control 50% ethanol, and normal). 200 mg of Aloe vera was extracted. A standardized 2 cm longitudinal incision wound was created. All mice were given topical &lt;em&gt;Aloe vera&lt;/em&gt;, 0.5 g each, once daily and assessment of wound surface was performed using OCT. The animals were sacrificed on day 10 to evaluate histopathologically. &lt;strong&gt;Results:&lt;/strong&gt; R parameter from the OCT was utilized to analyze the data. There is no significant difference in the treatment effect between &lt;em&gt;Aloe vera&lt;/em&gt; treated group and control on day 10 post-injury. Treated animals with precipitate did not differ significantly from supernatant treated group. Nevertheless, from histopathology analysis, precipitate showed better wound reepithelialisation, collagen formation and angionesis despite having numerous inflammatory cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; OCT using R parameter is not the best choice to detect wound healing. Nevertheless, from histopathological perspective, Aloe vera accelerates wound healing and precipitate Aloe vera gel does have a superior effect from supernatant in promoting wound healing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Nurrashida Binti Mok Hallim&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Anwar Ibrahim&lt;sup&gt;3&lt;/sup&gt;, Salinah&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Anatomical Pathology, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Medicinal Chemistry, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Medicinal Physic, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nitin Govindrao Dumore</style></author><author><style face="normal" font="default" size="100%">Milind Janrao Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author><author><style face="normal" font="default" size="100%">Manish Manohar Aglawe</style></author><author><style face="normal" font="default" size="100%">Nandkishor Ramdasji Kotagale</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Withania somnifera Nicotine Induced Conditioned Place Preference in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Condition place preference</style></keyword><keyword><style  face="normal" font="default" size="100%">Nicotine</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">43-47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Herbal medicines can be novel treatment strategies for management of nicotine addiction. Withania somnifera (Ashwagandha) is an Indian medicinal plant of great medicinal value; used in many clinically proven conditions. Objective: In present study we aimed at investigating the effect of withania somnifera extract (WSE) on preventing nicotine mediated effects attributed for the development of addiction. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Mice were treated with nicotine and/or WSE and subjected to nicotine induced conditioned place preference (CPP) in male albino mice was checked.&lt;strong&gt; Results: &lt;/strong&gt;Application of two-way ANOVA showed that with preconditioning and post-conditioning values as a within-subjects (column) factor and treatment as an independent between subject (row) factor. Two-way ANOVA revealed significant effect of treatment [F(3,40)=4.119, p&amp;lt;0.05], time [F(1,40)=23.76, p&amp;lt;0.001] and interactiontreatment x time [F(3,40)=5.244, p&amp;lt;0.01] on Intra-peritoneal (ip) administration of nicotine (1 mg/kg). WSE did not produce any changes in the preference to drug-paired compartment. Factors like treatment [F(3,40) = 0.656, p&amp;gt;0.05], time [F(1,40) = 7.383, p&amp;lt;0.01] and interactiontreatment x time [F(3,40) = 0.5748, p&amp;gt;0.05] showed insignificant effects. Withania somnifera (50,100,200 mg/kg ip) coadministered with nicotine during the 6 days conditioning sessions completely abolished the acquisition of nicotine-induced CPP in mice. &lt;strong&gt;Conclusion:&lt;/strong&gt; Above data indicate that withania somnifera attenuate nicotine induced CPP. Hence it has potential as an anti-addictive therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">43</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nitin Govindrao Dumore&lt;sup&gt;1,2*&lt;/sup&gt;, Milind Janrao Umekar&lt;sup&gt;1&lt;/sup&gt;, Brijesh GulabraoTaksande&lt;sup&gt;1&lt;/sup&gt;, Manish Manohar Aglawe&lt;sup&gt;1&lt;/sup&gt;, Nandkishor Ramdasji Kotagale&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Neuroscience, Department of Pharmacology, Smt.kishoritai Bhoyar College of pharmacy Kamptee, Nagpur 441002 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Dadasaheb Balpande College of Pharmacy, Besa, Nagpur,440037 Maharashtra, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Government college of Pharmacy, Amaravati, 444601, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Guseinov MD</style></author><author><style face="normal" font="default" size="100%">Bobkova NV</style></author><author><style face="normal" font="default" size="100%">Svistunov AA</style></author><author><style face="normal" font="default" size="100%">Tarasov VV</style></author><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Sergunova EV</style></author><author><style face="normal" font="default" size="100%">Kovaleva TYu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flavonoids in Passiflora incarnata L. Dry Extract of Russian Origin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dry extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Passiflora incarnata</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1143-1147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Flavonoids are one of the main classes of biologically active substances providing the pharmacotherapeutic effect of passionflower (&lt;em&gt;Passiflora incarnata&lt;/em&gt; L.) preparations. In this article studies on the standardization of &lt;em&gt;Passiflora incarnata&lt;/em&gt; L. dry extract (PDE) by flavonoids are presented. The aim of this work was to study the composition and content of flavonoids in PDE with the help of precise modern physicochemical methods. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; PDE was prepared from crude herbal drug – &lt;em&gt;P. incarnata&lt;/em&gt; herb of Russian origin. Reverse phase HPLC-UV analysis was performed with Agilent 1100 liquid chromatograph. Chromatographic column was Atlantis C&lt;sub&gt;18&lt;/sub&gt; (250 mm × 4.6 mm × 5 μm); analytical wavelength – 350 nm; mobile phase – 0.01% formic acid solution and methanol: acetonitrile (25:75); column temperature – 35°C; analysis time – 90 min; flow rate of the mobile phase – 0.8 ml/min in gradient elution mode. Commercially available samples of flavonoids were used for identification and quantitative determination. &lt;strong&gt;Results: &lt;/strong&gt;20 compounds of flavonoid structure are presented in the PDE. 9 flavonoid compounds have been identified, they are: isovitexin, vitexin, rutoside, hyperoside, luteolin, kaempferol, kaempferitrin, orientin, and isoorientin. The content of vitexin is 0,867 ± 0,011%, the total flavonoids content in terms of vitexin is 3,762 ± 0,049%. &lt;strong&gt;Conclusion: &lt;/strong&gt;The obtained data will be used to create regulatory documentation for drugs based on PDE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Guseinov MD&lt;sup&gt;1&lt;/sup&gt;, Bobkova NV&lt;sup&gt;2&lt;/sup&gt;, Svistunov AA&lt;sup&gt;2&lt;/sup&gt;, Tarasov VV&lt;sup&gt;2&lt;/sup&gt;, Bokov DO&lt;sup&gt;2,3,&lt;/sup&gt;*, Sergunova EV&lt;sup&gt;2&lt;/sup&gt;, Kovaleva TYu&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Medical College named after Bashlarov, Amet Khan Sultan Ave., 10th km., 367915, Makhachkala, Republic of Dagestan, RUSSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, 119991, RUSSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Federal Research Center for Nutrition, Biotechnology and Food Safety, 2/14, Ustyinsky pr., Moscow, 109240, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maria Carmen S. Tan</style></author><author><style face="normal" font="default" size="100%">Marissa G. Noel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Glucosinolates, Degradation Products and Myrosinase Activity in Raphanus sativus Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-FID</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucosinolates</style></keyword><keyword><style  face="normal" font="default" size="100%">Isothiocyanates</style></keyword><keyword><style  face="normal" font="default" size="100%">LC-ESI-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Myrosinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">866-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This research was conducted to assess the gluocosinolate (GSL), isothiocyanate (ITC) and myrosinase content in two cultivars of Raphanus sativus Linn. (white and red) roots. LC-ESIMS investigation was done on desulfated GSLs since this methodology has been previously established for efficient GSL analyses. The major GSLs: sinigrin &lt;strong&gt;(1)&lt;/strong&gt; 1,2-dihydroxy-2-phenylethyl glucosinolate &lt;strong&gt;(2)&lt;/strong&gt;, 4-hydroxyglucobrassicin &lt;strong&gt;(3)&lt;/strong&gt;, glucoraphasatin &lt;strong&gt;(4)&lt;/strong&gt; and 4-methoxyglucobrassicin &lt;strong&gt;(5)&lt;/strong&gt; were found in red radishes; whereas, only &lt;strong&gt;1&lt;/strong&gt; and &lt;strong&gt;4&lt;/strong&gt; were obtained in white radishes. Myrosinase was analyzed in the tubers due to its ability to catalyze and hydrolyze GSLs into ITCs. This β-thioglucosidase enzyme was found to be over 10 times more active in red tubers (2.05E-02 units) than in white radishes (1.55E-03 units) and the results were linked to the presence/absence of the outer covering of the tubers. Due to the promising medicinal properties of the aglucone derivative of compound 4, 4-methylthio-3-butenyl isothiocyanate &lt;strong&gt;(6)&lt;/strong&gt;, the ITC analog was monitored using gas chromatographic mass spectral analyses after myrosinase-mediated hydrolysis. From the results, it can be construed that the occurrence of GSLs&lt;strong&gt; 1-5&lt;/strong&gt; and the bioactive agent &lt;strong&gt;6&lt;/strong&gt; were inherent in the R. sativus cultivars evaluated.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">866</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maria Carmen S. Tan*, Marissa G. Noel&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mfengwana Polo-Ma-Abiele H</style></author><author><style face="normal" font="default" size="100%">Mashele Samson S</style></author><author><style face="normal" font="default" size="100%">Manduna Idah T</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antibacterial, Antioxidant and Anti-Inflammatory Effects of Senecio asperulus and Gunnera perpensa from Mohale's Hoek, Lesotho</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gunnera perpensa</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Senecio asperulus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">730-739</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Traditional medicinal plants have been widely used to treat or manage various ailments for centuries in Lesotho. With an increase in multi drug resistance and undesired adverse events to current drugs challenges, there is a need for alternative drugs. &lt;strong&gt;Aim:&lt;/strong&gt; In this study we aimed at the investigation of antibacterial, antioxidant and anti-inflammatory effects of &lt;em&gt;Senecio asperulus&lt;/em&gt; and &lt;em&gt;Gunnera perpensa&lt;/em&gt; roots extracted in three solvents of different polarities. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Antibacterial activity was determined using the disc diffusion method, while antioxidant activity was determined using free radical scavenging of 2,2-diphenyl-1-picrylhydrazyl and the ferric reducing antioxidant power assay. The Lipopolysaccharide (LPS) stimulated RAW 264.7 mouse macrophage &lt;em&gt;in vitro&lt;/em&gt; model was used to evaluate the anti-inflammatory activity of both plants. Resveratrol was used as a positive control. &lt;strong&gt;Results:&lt;/strong&gt; Methanol extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; inhibited microbial growth even at the lowest concentration of 50 μg/ml. &lt;em&gt;Senecio asperulus &lt;/em&gt;dichloromethane extract was active on most bacteria with MIC’s between 50 μg/ml and 500 μg/ml. However, the water and methanol extracts of &lt;em&gt;Gunnera perpensa&lt;/em&gt; had no activity against all organisms tested. Aqueous extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; and &lt;em&gt;Gunnera perpensa&lt;/em&gt; showed free radical scavenging activity yielding EC&lt;sub&gt;50&lt;/sub&gt; values of 100 μg/ml and 25 μg/ml, respectively. The aqueous extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; showed moderate anti-inflammatory activity from 50 to 200 μg/ml. while the methanol extract was at 200 μg/ml and with no cytotoxicity. No anti-inflammatory activity was observed from all&lt;em&gt; Gunnera perpensa&lt;/em&gt; extracts using LPS-induced macrophages, this suggests that this species may be using other mechanisms for anti-inflammatory activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;The antibacterial, antioxidant and anti-inflammatory activities observed from water extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; support its ethnomedicinal use for the management of inflammation related diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">730</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mfengwana Polo-Ma-Abiele H&lt;sup&gt;1,*&lt;/sup&gt;, Mashele Samson S&lt;sup&gt;2&lt;/sup&gt;, Manduna Idah T&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Health Sciences, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Unit for Drug Discovery Research, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Applied Food Security and Biotechnology, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ika Rahayu</style></author><author><style face="normal" font="default" size="100%">Pamela Hendra Heng</style></author><author><style face="normal" font="default" size="100%">Kris H Timotius</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antioxidant Properties and α-Glucosidase Inhibition of Combined Leaf Infusions from Psidium guajava L., Syzygium polyanthum L., and Annona muricata L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anonna muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf infusion</style></keyword><keyword><style  face="normal" font="default" size="100%">Psidium guajava</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergism</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium polyanthum</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1269-1277</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Guava (&lt;em&gt;P. guajava&lt;/em&gt;), bay (&lt;em&gt;S. polyanthum&lt;/em&gt;), and soursop (&lt;em&gt;A. muricata&lt;/em&gt;) known as natural medicine. Limited report is available on their antioxidant and α-glucosidase inhibitory activities of leaf infusion. The aims of this research were to compare the antioxidant and α-glucosidase inhibitory activities of leaf infusion from guava, bay, and either as individual or combined infusions, and to analyze the chemical composition of the leaf infusion. &lt;strong&gt;Methods:&lt;/strong&gt; Air dried leaf powder of guava, bay and soursop were infused separately with boiled aquadest. The infusions were analyzed for their antioxidant activity against DPPH. The α-glucosidase inhibitory assay was conducted against α-glucosidase from &lt;em&gt;Saccharomyces cerevisiae. &lt;/em&gt;Then the infusions scanned with UV-Vis spectroscopy and analyzed with LC-MS. The synergism activities of the combined infusion were measured. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activities of leaf infusions of guava and bay showed a comparable result IC&lt;sub&gt;50&lt;/sub&gt; 12.53 ± 0.55 and 10.76 ± 0.20 μg GAE/mL, but the infusion of soursop showed lower (IC&lt;sub&gt;50&lt;/sub&gt; 19.77 ± 0.35 μg GAE/mL) than BHT as positive control (11.6 ± 0.31 μg GAE/mL). If soursop infusion was not added, then the mixture of the guava and bay infusion showed an antioxidative synergistic effect. The α-glucosidase inhibitory activities of the guava, bay and soursop infusion (0.083 ± 0.01; 0.025 ± 0.007; 0.533 ± 0.039 μg GAE/mL, respectively) were stronger than acarbose (1285 ± 148 μg/mL). The α-glucosidase inhibitory activities of the combined infusions showed a synergistic effect. The main constituents of the guava infusion were identified tentatively as chrysin and caffeoylquinic acid, for the bay infusion it was caffeoylquinic, and for the soursop infusion it was luteolin. &lt;strong&gt;Conclusions:&lt;/strong&gt; There is a significant synergism of antioxidant activity of Guava and Bay mixture. The combined infusion of Bay and Soursop or Guava and Soursop showed antagonistic effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1269</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ika Rahayu&lt;sup&gt;1&lt;/sup&gt;, Pamela Hendra Heng&lt;sup&gt;2&lt;/sup&gt;, Kris H. Timotius&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Universitas Kristen Krida Wacana (UKRIDA), Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Psychology, Universitas Tarumanagara, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thiraviyam Anand</style></author><author><style face="normal" font="default" size="100%">Mahalingam Sundararajan</style></author><author><style face="normal" font="default" size="100%">Muniyandi Anbukkarasi</style></author><author><style face="normal" font="default" size="100%">Philip Aloysius Thomas</style></author><author><style face="normal" font="default" size="100%">Pitchairaj Geraldine</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Methanolic Extract of Ocimum basilicum Exhibits Antioxidant Effects and Prevents Selenite-induced Cataract Formation in Cultured Lenses of Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Cataract</style></keyword><keyword><style  face="normal" font="default" size="100%">Crystallins</style></keyword><keyword><style  face="normal" font="default" size="100%">Ocimum basilicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">496-504</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; An extract (Methanolic) of the&lt;em&gt; Ocimum basilicum &lt;/em&gt;leaf was analysed for potential to abrogate experimental formation of cataract &lt;em&gt;in-vitro.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; Phytoconstituents were first detected in &lt;em&gt;O. basilicum&lt;/em&gt; extracts (Aqueous or methanolic) by gas chromatographic-mass spectrometric analysis. The putative antioxidant activity of these extracts was then assessed by measuring &lt;em&gt;in-vitro &lt;/em&gt;radical-scavenging activity, ion-chelating potential and reducing potency. Potential cytotoxicity of the extract on Human lenticular epithelial B3 (HLE-B3) cells was also sought. Finally, possible prevention of cataract formation by the methanolic extract was gauged in selenite-exposed lenses obtained from Wistar rats. There were 3 groups (8 Lenses in each): Group I (Lenses incubated in Dulbecco’s modified Eagle’s medium [DMEM] alone); Group II (Lenses incubated in DMEM with sodium selenite [100 &lt;em&gt;μ&lt;/em&gt;M/ml]); Group III (Lenses incubated in DMEM with selenite [100 &lt;em&gt;μ&lt;/em&gt;M/ml] and the &lt;em&gt;O. basilicum&lt;/em&gt; methanolic extract (200 &lt;em&gt;μ&lt;/em&gt;g/ml DMEM). Gross lenticular morphology was assessed. Levels of lenticular malondialdehyde (MDA) and reduced glutathione (GSH) were also measured. &lt;strong&gt;Results:&lt;/strong&gt; A higher intensity of antioxidative activity was noted in the methanolic extract than in the aqueous extract. The methanolic extract exhibited negligible cytotoxicity. On morphological examination, marked opacification was seen in all 8 Group II lenses whereas there was no opacification in 7 of 8 Group III lenses. Near normal mean levels of reduced glutathione and malondialdehyde, were noted within Group III lenses. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanolic extract of the &lt;em&gt;O. basilicum&lt;/em&gt; leaf appears to prevent selenite-induced cataract formation&lt;em&gt; in-vitro.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">496</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thiraviyam Anand1, Mahalingam Sundararajan&lt;sup&gt;1&lt;/sup&gt;, Muniyandi Anbukkarasi&lt;sup&gt;1&lt;/sup&gt;, Philip Aloysius Thomas&lt;sup&gt;2&lt;/sup&gt;, Pitchairaj Geraldine&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli- 620024, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ocular Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli- 620024, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Nguyen Van Manh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Ha Bui Thi Thu</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Le Bach Quang</style></author><author><style face="normal" font="default" size="100%">Pham Gia Khanh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A New LC/MS/MS Method for the Analysis of Phyllanthin in Rat Plasma and its Application on Comparative Bioavailability of Phyllanthin in Different Formulations after Oral Administration in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">LC-MS/MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacokinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Phospholipid</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthin</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">968-975</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The validated method was used to investigate the pharmacokinetic properties of phyllanthin in PA extract and phospholipid complex of PA extract in rat. &lt;strong&gt;Methods:&lt;/strong&gt; The separation was carried out on Acquity C&lt;sub&gt;18 &lt;/sub&gt;(50 x 2.1 mm; 1.7 μm), with a mobile phase of 10 mM aqueous amonium acetate and acetonitrile (10:90; v/v), at a flow rate of 0.2 mL/min. Felodipin was used as internal standard. Phyllanthin is extracted from a small volume of rat plasma (100 μl) by means of liquid-liquid extraction method with tert butyl methyl ether. Electrospray ionization (ESI) mass spectrometry was applied in positive mode at capillary voltage of 4000 V for both phyllanthin and IS, cone voltage of 24 V for phyllanthin and 20 V for IS, desolvation temperature of 360oC, cone gas flow of 25 L/h, collision energy of 12 V for phyllanthin and 10 V for IS. Multiple reaction monitoring (MRM) was used to monitor the transitions at m/z (Q1/Q3) 436.41/355.36 for phyllanthin and 384.20/352.18 for IS. &lt;strong&gt;Results:&lt;/strong&gt; The linear calibration curve of phyllanthin was obtained over the concentration range of 0.5 – 100 ng/mL. The intra‐ and inter‐day precisions were less than 7.08 % and the accuracies were within ± 7.55%. The Cmax values of phyllanthin from two different preparations in rat plasma after oral administration of 2.0 mg/kg were 11.44 and 31.44 ng/ml, and the AUC values were 18.07 and 41.43 h.ng/ml, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; A simple, short UPLC/MS/MS method for quantitation of phyllanthin in rat plasma in less than 2 minutes have been developed and fully validated. The bioavailability of phyllanthin from the phospholipid complex of PA extract in rat plasma was significantly improved compared with that of raw PA extract after oral administration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">968</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;#&lt;/sup&gt;, Chu Van Men&lt;sup&gt;#,&lt;/sup&gt;*, Anh Vu Tuan, Nguyen Van Manh, Thanh Chu Duc, Ha Bui Thi Thu, Hoang Van Luong, Le Bach Quang, Pham Gia Khanh&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;nstitute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paphitchaya Thetsana</style></author><author><style face="normal" font="default" size="100%">Chayanon Chaowuttikul</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specifications, Quercetin and Quercitrin Quantification in Bauhinia malabarica Leaf</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bauhinia malabarica Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf measurement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercitrin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">155-160</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Bauhinia malabarica&lt;/em&gt; Roxb. is a tropical tree that found throughout Thailand. Leaves have a sour taste and have been used in Thai remedies for wound healing, diuretic, dysentery and emmenagogue. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to focus on pharmacognostic specification and quantitative analysis of quercetin and quercitrin in &lt;em&gt;B. malabarica&lt;/em&gt; leaves. &lt;strong&gt;Methods:&lt;/strong&gt; Various methods such as macroscopic and microscopic evaluations of &lt;em&gt;B. malabarica&lt;/em&gt; leaf were studied along with physico-chemical parameters and quantitated quercetin and quercitrin using RP-HPLC. &lt;strong&gt;Results and Conclusion:&lt;/strong&gt; Whole plant, structures of dried powder crude drug, cross section of midrib and leaf measurement were established. Paracytic stomata and multicellular trichome were found on lower epidermis. &lt;em&gt;B. malabarica&lt;/em&gt; leaves from 15 sources throughout Thailand were examined the pharmacognostic specification according to WHO guideline. Physico-chemical parameters showed that loss on drying, total ash, acid insoluble ash and water content should not be more than 8.00, 7.08, 1.79 and 8.28 % of dry weight while ethanol and water soluble extractive values should not be less than 13.78 and 16.47 % of dry weight respectively. Quercetin and quercitrin were the markers for quantitative analysis using RP-HPLC with diode array detector in &lt;em&gt;B. malabarica&lt;/em&gt; ethanolic extract. Quercetin and quercitrin contents were found to be 0.18 g and 0.38 g in 100 g of dried crude drug. Method validation was determined according to ICH guideline. All results were in the acceptable range and could be used for identity, safety, efficacy and quality of &lt;em&gt;B. malabarica&lt;/em&gt; leaves in Thailand.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Paphitchaya Thetsana&lt;sup&gt;1&lt;/sup&gt;, Chayanon Chaowuttikul&lt;sup&gt;1&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt;, Nijsiri Ruangrungsi&lt;sup&gt;1,2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand, ASIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand, ASIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pushpender Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Mohan Singh Thakur</style></author><author><style face="normal" font="default" size="100%">Sahil Kapoor</style></author><author><style face="normal" font="default" size="100%">Ashwani Kumar Bhardwaj</style></author><author><style face="normal" font="default" size="100%">Ajay Sharma</style></author><author><style face="normal" font="default" size="100%">Shweta Saxena</style></author><author><style face="normal" font="default" size="100%">Om Prakash Chaurasia</style></author><author><style face="normal" font="default" size="100%">Raj kumar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Activity Study of Methanol Extract of Stems and Roots of Codonopsis clematidea from Trans-himalayan Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Codonopsis clematidea</style></keyword><keyword><style  face="normal" font="default" size="100%">Fructose</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">MER</style></keyword><keyword><style  face="normal" font="default" size="100%">MES</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">536-546</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present report aimed to study the therapeutic and phytochemical properties of stems and roots of trans-himalayan plant &lt;em&gt;Codonopsis clematidea.&lt;/em&gt; &lt;strong&gt;Material and Methods:&lt;/strong&gt; The crude samples of stems and roots were explored for their chlorophyll, carotenoid and carbohydrate content in order to understand the matrix of these two plant parts. The extraction of phytochemicals was carried out by three different methods&lt;em&gt; viz&lt;/em&gt;. sonication, maceration and soxhlet in methanol to identify the best extraction method. Further, analysis of Total Flavonoid Content (TFC) and Total Polyphenolic Content (TPC) were carried out using rutin trihydrate and gallic acid as a reference standard. Antioxidant capacity was estimated using three methods viz. 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical scavenging assay and Ferric Reducing Antioxidant Power (FRAP) assay. In addition to this, GC-MS analysis was also performed for the identification of volatile constituents of Methanol Extract of Stems (MES) and Methanol Extract of Roots (MER). &lt;strong&gt;Results: &lt;/strong&gt;The MES and Dimethylsulfoxide Extract of Stems (DES) were found to have higher Chlorophyll a (Ch&lt;sub&gt;a&lt;/sub&gt;) content in comparison to Chlorophyll b (Ch&lt;sub&gt;b&lt;/sub&gt;) and Carotenoids (C&lt;sub&gt;ca&lt;/sub&gt;). Carbohydrate profile showed that stems and roots have the highest content of fructose in comparison to other sugar moieties. The soxhlet method showed the highest percentage extractive yield in the stems as well as roots. Results revealed that the MES showed higher antioxidant potential as compared to the MER. A correlation has also found to exist between the results of TPC, TFC and antioxidant assays, since TPC and TFC are key constituents responsible for the antioxidant potential. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results have been found to suggest the richness of MES in natural phenols, flavonoids and antioxidants. Further, study should be conducted over identification and characterization of compounds present in the extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">536</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pushpender Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Mohan Singh Thakur&lt;sup&gt;1&lt;/sup&gt;, Sahil Kapoor&lt;sup&gt;1&lt;/sup&gt;, Ashwani Kumar Bhardwaj&lt;sup&gt;1&lt;/sup&gt;, Ajay Sharma&lt;sup&gt;2&lt;/sup&gt;, Shweta Saxena&lt;sup&gt;1&lt;/sup&gt;, Om Prakash Chaurasia&lt;sup&gt;1&lt;/sup&gt;, Raj Kumar&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Plant, Defence Institute of High-Altitude Research c/o 56 APO, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Sant Longowal Institute of Engineering and Technology, Longowal, Sangrur, Punjab-148106, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Bui Thi Thu Ha</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Nguyen Tung Linh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Phung Cao Dai</style></author><author><style face="normal" font="default" size="100%">Chul Soon Yong</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuminoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FACS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1037-1045</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Curcuminoids, the bioactive compounds extracted from &lt;em&gt;Curcuma longa &lt;/em&gt;consisting of Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), have shown promising biological effects, including anticancer activity. This study sought to prepare a physically stable phytosomal nanoparticles of curcuminoids (Curs-Phyto) to facilitate uptake of curcuminoids on breast cancer cells line, and further increase the cytotoxicity against cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The evaporation combined extrusion technique was employed to prepare phytosomal curcuminoids nanoparticles. The interaction between curcuminoids and phospholipid by a hydrogen bond was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), fourier transform infrared (FT-IR), and &lt;sup&gt;1&lt;/sup&gt;H nuclear magnetic resonance (&lt;sup&gt;1&lt;/sup&gt;H-NMR). Their physicochemical characterizations and stability in simulated gastric and intestinal media were investigated. The effects of Curs-Phyto on MCF-7 cells were evaluated by flow cytometry, MTS assay and cell cycle analysis. &lt;strong&gt;Results:&lt;/strong&gt; We found that the Curs-Phyto were formed at a spherical shape with good size (~ 180 nm), a narrow size distribution (PDI &amp;lt; d0.2), high complexation rate (~ 87%, 95%, and 90% for BDMC, DMC, and CUR respectively) and high loading capacity of curcuminoids. More importantly, the Curs-Phyto showed the increased cellular uptake and enhanced cytotoxicity against MCF- 7 cancer cells, compared to free curcuminoids. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results indicated that the phytosome could be a promising oral delivery system for curcuminoids for cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;1,#&lt;/sup&gt;, Bui Thi Thu Ha&lt;sup&gt;1,#&lt;/sup&gt;, Anh Vu Tuan&lt;sup&gt;1&lt;/sup&gt;, Hoang Van Luong&lt;sup&gt;1&lt;/sup&gt;, Nguyen Tung Linh&lt;sup&gt;1&lt;/sup&gt;, Thanh Chu Duc&lt;sup&gt;1&lt;/sup&gt;, Phung Cao Dai&lt;sup&gt;2&lt;/sup&gt;, Chul Soon Yong&lt;sup&gt;2&lt;/sup&gt;, Chu Van Men&lt;sup&gt;1,#&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics, College of Pharmacy, Yeungnam University, 214-1 Dae-Dong, Gyeongsan 712-749, REPUBLIC OF KOREA. #These authors contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imad M Al-Ani</style></author><author><style face="normal" font="default" size="100%">Norsidah Ku-Zaifah</style></author><author><style face="normal" font="default" size="100%">Fakhria A. Al-Joufi</style></author><author><style face="normal" font="default" size="100%">Rafidah H.Mokhtar</style></author><author><style face="normal" font="default" size="100%">Norlelawati A. Talib</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eurycoma Longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Fat-Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Seminiferous Tubules Tongkat Ali</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">808-811</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether &lt;em&gt;Eurycoma longifolia&lt;/em&gt; (EL) is able to ameliorate these effects. &lt;strong&gt;Methods:&lt;/strong&gt; Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal’s testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12&lt;sup&gt;th &lt;/sup&gt;weeks and the testes samples were processed for histological examination&lt;strong&gt; Results: &lt;/strong&gt;The testosterone level was significantly increased (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">808</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Imad M Al-Ani&lt;sup&gt;1&lt;/sup&gt;, Norsidah Ku-Zaifah&lt;sup&gt;2&lt;/sup&gt;, Fakhria A. Al- Joufi&lt;sup&gt;3&lt;/sup&gt;, Rafidah H.Mokhtar&lt;sup&gt;4&lt;/sup&gt;, Norlelawati A. Talib&lt;sup&gt;5&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;6,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dentistry, Al-Hikmah University College, Al-Yarmook, Baghdad, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Pharmacy, Al Jouf University, Aljouf, Skaka KSA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Fundamental Dental and Medical sciences, Kulliyyah of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thanyathorn Tangsongcharoen</style></author><author><style face="normal" font="default" size="100%">Somchai Issaravanich</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantitative Analysis of Hispidulin Content in Clerodendrum petasites Roots Distributed in Thailand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ben-Cha-Lo-Ka-Wi-Chian remedy</style></keyword><keyword><style  face="normal" font="default" size="100%">Clerodendrum petasites</style></keyword><keyword><style  face="normal" font="default" size="100%">hispidulin</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-PDA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1093-1099</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Clerodendrum petasites&lt;/em&gt; (Lour.) S. Moore (locally known as Mai-Thao-Yaai-Mom), belonging to the Verbenaceae family, is widely formulated into multi-herb remedy, Ben-Cha- Lo-Ka-Wi-Chian remedy, possessing antipyretic activity. &lt;em&gt;C. petasites&lt;/em&gt; exhibits many biological activities, such as antioxidant, anti-inflammatory, antipyretic, etc. The flavonoid hispidulin is one of the main active compounds present in &lt;em&gt;C. petasites&lt;/em&gt;, containing anti-atheromatous, antitumor and antispasmodic effects. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to determine the hispidulin content in the dried roots of &lt;em&gt;C. petasites &lt;/em&gt;using HPLC technique.&lt;strong&gt; Methods:&lt;/strong&gt; &lt;em&gt;C. petasites &lt;/em&gt;dried roots, collected from twelve different areas, were extracted with ethanol using Soxhlet apparatus, and then subjected to HPLC-PDA to quantify hispidulin content. The quantitative method using HPLC-PDA technique was validated.&lt;strong&gt; Results:&lt;/strong&gt; The optimized HPLC coupling with PDA detector (HPLC-PDA) was validated for the quantitative analysis of hispidulin content in &lt;em&gt;C. petasites&lt;/em&gt; roots in terms of linearity (y = 210,200,536.6667x – 448,756.2667; R&lt;sup&gt;2&lt;/sup&gt; = 0.9997), accuracy (88.82-107.69% recovery), precision (0.66% RSD for repeatability precision; 1.17% RSD for intermediate precision), limit of detection (2.30 μg/mL), limit of quantitation (7.00 μg/mL), specificity (peak purity index = 1.0000) and robustness (% RSD &amp;lt; 1). The amount of hispidulin content in the extracts of &lt;em&gt;C. petasites&lt;/em&gt; roots conducted from the validated method was found to be 0.0182 ± 0.0109 g/100 g crude drug. &lt;strong&gt;Conclusion: &lt;/strong&gt;The HPLC-PDA analysis was able to effectively determine hispidulin in &lt;em&gt;C. petasites&lt;/em&gt; roots. The hispidulin contents in &lt;em&gt;C. petasites&lt;/em&gt; dried roots from various areas in Thailand were revealed which could be used for the specification of this crude drug with reference to its chemical marker.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1093</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Thanyathorn Tangsongcharoen&lt;sup&gt;1&lt;/sup&gt;, Somchai Issaravanich&lt;sup&gt;1&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1,&lt;/sup&gt;* , Nijsiri Ruangrungsi&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Rangsit University, Pathum Thani 12000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olga Trifonova</style></author><author><style face="normal" font="default" size="100%">Olga Evdokimova</style></author><author><style face="normal" font="default" size="100%">Vera Prokofieva</style></author><author><style face="normal" font="default" size="100%">Alexey Matyushin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Rationale for Manufacturing of Cut-Pressed Granules from Herbal Raw Material Rich in Essential Oil: An Example of Chamomile Flowers and Sweet Flag Rhizome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chamomile</style></keyword><keyword><style  face="normal" font="default" size="100%">Cut-pressed granules</style></keyword><keyword><style  face="normal" font="default" size="100%">Dosage form</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet flag</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1285-1289</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Currently, there are at least 43 different dosage forms present on the Russian Federation pharmaceutical market. A novel, unique dosage form – cut-pressed granules (CPG) – was developed in order to improve manufacturing characteristics and, therefore, quality of herbal drug products released in tea bags. However, treatment conditions may result in decreased levels of active substances in some of the plants, especially those containing essential oil, which is prone to degradation. The aim of this study was to assess feasibility of CPG manufacturing from herbal raw material rich in essential oil. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Different morphological groups of raw material from two commonly used medicinal plants, chamomile (&lt;em&gt;Matricaria recutita&lt;/em&gt; L.) flowers and sweet flag (&lt;em&gt;Acorus calamus&lt;/em&gt; L.) rhizome, were chosen as the objects of the study. Qualitative composition of lipophilic constituents in herbal raw materials and CPG was assessed using thin-layer chromatography. Essential oil content was determined by steam distillation.&lt;strong&gt; Results:&lt;/strong&gt; The results confirmed equivalence of chromatographic profiles for the analyzed raw materials and CPG; thus, granulation didn’t affect qualitative composition of lipophilic components in chamomile flowers and sweet flag rhizome. The study also showed that the granulation process, in fact, promoted stability of the dosage form: during long-term storage the content of essential oil in all of the assessed cut-pressed granules was equivalent or higher than in corresponding herbal raw material. &lt;strong&gt;Conclusions:&lt;/strong&gt; It can be concluded that &lt;em&gt;Matricaria recutita &lt;/em&gt;L. flowers and &lt;em&gt;Acorus calamus&lt;/em&gt; L. rhizome can be used as herbal raw material for CPG manufacturing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1285</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olga Trifonova&lt;sup&gt;1,2&lt;/sup&gt;, Olga Evdokimova&lt;sup&gt;3&lt;/sup&gt;, Vera Prokofieva&lt;sup&gt;4&lt;/sup&gt;, Alexey Matyushin&lt;sup&gt;5&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;JSC “Krasnogorskleksredstva”, Krasnogorsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Federal State Budgetary Institution Scientific Centre for Expert Evaluation of Medicinal Products of the Ministry of Health of the Russian Federation, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;A.P. Arzamastsev Department of Pharmaceutical and Toxicological Chemistry, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Analytical and Forensic Toxicology, Sechenov First Moscow State Medical University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sasithorn Tandhavadhana</style></author><author><style face="normal" font="default" size="100%">Chayan Picheansoonthon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Reduction of Colchicine Content from Radix Gloriosae Superbae Preparata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Colchicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Gloriosae Superbae Radix</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pre-treat method</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai herbal remedy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">310-314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Gloriosae Superbae Radix is a crude drug employed in Thai herbal remedies for several ailments. Colchicine is known as an active constituent in the roots. It was reported that 7-11 mg. of colchicine may causes lethal effect in human. In Thai traditional medical practice, the roots must be treated prior use to prepare Thai herbal preparations. However, pre-treated method has not yet been well established in any literature. This study aimed to document the pre-treated method and to quantitatively compare the amount of colchicine both before and after pre-treated. &lt;strong&gt;Methods:&lt;/strong&gt; Firstly, interviewing with Thai traditional medicine experts and document the pre-treated methods of Gloriosae Superbae Radix to conclude the 2 commonly used methods. Two pre-treated methods (roasting and burning) were chosen for further study. Colchicine in Gloriosae Superbae Radix from 8 sources were analyzed before and after pre-treat by High Performance Liquid Chromatography (HPLC). &lt;strong&gt;Results:&lt;/strong&gt; After pre-treat by roasting and burning, amount of colchicine in root were significantly decreased by 40.61±9.55% (&lt;em&gt;p&lt;/em&gt;=0.000) and 26.79±10.89% (&lt;em&gt;p&lt;/em&gt;=0.001), respectively. Comparison of colchicine contents of samples after roasting and burning, the amount of colchicine decreased non statistically insignificantly (&lt;em&gt;p&lt;/em&gt;=0.110). &lt;strong&gt;Conclusion:&lt;/strong&gt; Pre-treats of Gloriosae Superbae Radix by roasting and burning had significantly reduce colchicine content. Both methods have been proven to be the effective ways in preparing certain potentially toxic crude drugs before using in compounding into Thai herbal remedies.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">310</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sasithorn Tandhavadhana, Chayan Picheansoonthon&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Faculty of Medicine, Mahasarakham University, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Balaji Kyathegowdanadoddi Srinivas</style></author><author><style face="normal" font="default" size="100%">Madhu Chakkere Shivamadhu</style></author><author><style face="normal" font="default" size="100%">Preethi Saligrama Devegowda</style></author><author><style face="normal" font="default" size="100%">Gurukar Mathew</style></author><author><style face="normal" font="default" size="100%">Theethagounder Tamizhmani</style></author><author><style face="normal" font="default" size="100%">Senthilkumar Gnanavadevel Prabhakaran</style></author><author><style face="normal" font="default" size="100%">Shankar Jayarama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening and Evaluation of Lectin and Anti-Cancer Activity from the Phloem Exudate/Sap of the Indian Dietary Ethnomedicinal Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">EAC</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemagglutination</style></keyword><keyword><style  face="normal" font="default" size="100%">Lectin</style></keyword><keyword><style  face="normal" font="default" size="100%">VEGF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">570-578</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Lectins are extremely significant biomolecules to study several biological progressions. In this present investigation, we are screening the crude phloem exudate/ sap sample from different ethnomedicinal plants were evaluated for lectin and anticancer activity. &lt;strong&gt;Methods:&lt;/strong&gt; The lectin activity of crude phloem exudate/sap samples were confirmed by haemgglutination assay and anticancer activity by using trypan blue, MTT and in-ovo CAM angiogenic assay. The tumor cell nuclei resulting in Giemsa stain, AO/EtBr stain, DNA Fragmentation and Caspase- 3 inhibitor assay. &lt;strong&gt;Results:&lt;/strong&gt; Our experimental data show that the phloem exudate/sap sample S2 (Musa Acuminata), sample S4 (Euphorbia Geniculate) exerting the potent lectin activity, sample S5 exerting very low lectin activity against the trypsinized rabbit erythrocytes and decreases the cell viability in EAC cells in-vitro. Sample S2, S4 and S5 exerts significant cytotoxic effect against the various human cancer cell lines and regressed the neovasculature (development of new blood vessels) in the developing CAM embryos when compared to the other crude samples. The apoptotic inducing activity of crude phloem exudate/sap samples was revealed by DNA fragmentation assay, caspase-3 inhibitor assay and cellular morphology were studied by fluorescence staining methods. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study reports that some of the isolated crude phloem exudate/sap samples show potent lectin activity and anti-cancer activity in different human cancer cell lines. The further additional experiment needs to purify and characterize the bioactive lectin components from the potent sample which is responsible for pro-apoptotic, anti-angiogenic activity and mechanism involved.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">570</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Balaji Kyathegowdanadoddi Srinivas&lt;sup&gt;1&lt;/sup&gt;, Madhu Chakkere Shivamadhu&lt;sup&gt;1,2&lt;/sup&gt;, Preethi Saligrama Devegowda&lt;sup&gt;3&lt;/sup&gt;, Gurukar Mathew&lt;sup&gt;4&lt;/sup&gt;, Theethagounder Tamizhmani&lt;sup&gt;5&lt;/sup&gt;, Senthilkumar Gnanavadevel Prabhakaran&lt;sup&gt;5&lt;/sup&gt;, Shankar Jayarama&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post-Graduation Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysore, Karnataka 570011, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Yuvaraja’s College, University of Mysore, Mysuru, Karnataka 570005, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Studies in Biotechnology, University of Mysore, Mysuru, Karnataka 570006, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Botany, Bharathi College, Affiliated University of Mysore, Bharathi Nagara, KM Doddi, Mandya, Karnataka 571422, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacy, Bharathi College of Pharmacy, Bharathi Nagara, KM Doddi, Mandya, Karnataka 571422, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jasmin T Tutor</style></author><author><style face="normal" font="default" size="100%">Christine L Chichioco-Hernandez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Angiotensin-Converting Enzyme Inhibition of Fractions from Eleusine indica Leaf Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">High-blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/360</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">25-28</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Solvent fractions and decoction of &lt;em&gt;Eleusine indica&lt;/em&gt; leaves were tested for their ability to inhibit angiotensin-converting enzyme (ACE), an important component of the Renin-Angiotensin- Aldosterone System which is a critical regulator of arterial blood pressure. The ACE inhibitory activity of each fraction was measured by employing a colorimetric assay based on the hydrolysis of histidyl-hippuryl-leucine (HHL) by ACE. Preliminary assay results revealed that the ethyl acetate fraction exhibited the highest antihypertensive activity with a percent inhibition of 51.51%. This fraction was considered for further isolation using a bioassay-guided fractionation scheme.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">25</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jasmin T Tutor, Christine L Chichioco-Hernandez* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Institute of Chemistry, University of the Philippines,&amp;nbsp;Diliman, Quezon City-1101, PHILIPPINES&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oukacha Amri</style></author><author><style face="normal" font="default" size="100%">Abderrahmane Zekhnini</style></author><author><style face="normal" font="default" size="100%">Abdellah Bouhaimi</style></author><author><style face="normal" font="default" size="100%">Saida Tahrouch</style></author><author><style face="normal" font="default" size="100%">Abdelhakim Hatimi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Plantar edema</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/369</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">71-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The extracts of the &lt;em&gt;Pistacia&lt;/em&gt; species are known for their anti-inflammatory activity, including fruits and oil of &lt;em&gt;P.&amp;nbsp;atlantica.&lt;/em&gt; However, the inflammatory effect of the methanolic extract of &lt;em&gt;P.&amp;nbsp;atlantica&lt;/em&gt; leaves has not been studied. This work aimed at assessing the antiinflammatory and antioxidant activities of &lt;em&gt;P.&amp;nbsp;atlantica&lt;/em&gt; leaves extract in relation to phytochemical studies of flavonoids. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was obtained using sonication of leaves powder in 80 % methanol. The analysis of phenolic compounds was carried out using thin-layer chromatography (TLC). The antioxidant activity was evaluated using DPPH, ABTS and FRAP assays. The anti-inflammatory activity was determined by the reduction of carrageenaninduced hind paw edema in mice. &lt;strong&gt;Results:&lt;/strong&gt; The TLC revealed 3 glycosylated flavonoids and gallic acid derivatives. The flavonoids identified corresponded to rutin, quercetrin and other heterosides of quercetin, kaempferol and myricetin. Total phenolics and flavonoids contents were comparable for the male and female trees. The antioxidant activity did not show a significative difference between the two sexes, except for that evaluated by the FRAP assay which was significantly greater for the male tree leaves extract. The leaves extract permitted significative reduction of the edema at h3 and 6 in a dose-dependent manner (100 and 250 mg/kg), while diclofenac used as control reduced the edema at h 1.5. This difference could be explained by the pharmacokinetic and pharmacodynamic properties of diclofenac and &lt;em&gt;P. atlantica &lt;/em&gt;leaves compounds. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;P. atlantica&lt;/em&gt; has a strong anti-inflammatory activity and constitutes a potential source for the development of new treatments.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Oukacha Amri&lt;sup&gt;1&lt;/sup&gt;, Abderrahmane Zekhnini&lt;sup&gt;2&lt;/sup&gt;*, Abdellah Bouhaimi&lt;sup&gt;2&lt;/sup&gt;, Saida Tahrouch&lt;sup&gt;1&lt;/sup&gt;, Abdelhakim Hatimi&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratoire de Biotechnologies V&amp;eacute;g&amp;eacute;tales, Facult&amp;eacute; des Sciences, 80 000 Agadir, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratoire des Syst&amp;egrave;mes Aquatiques, Facult&amp;eacute; des Sciences, 80 000 Agadir, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ladachart Taepongsorat</style></author><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activities of Ethanolic and Aqueous Extracts of Asparagus racemosus Roots</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Asparagus racemosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compound</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1129-1132</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Asparagus racemosus&lt;/em&gt; (AR) is commonly known as shatavari, satawar or satmuli in India and in Thailand it is call sam-sib or rak-sam-sib. The dried root of AR is used in Ayurveda as an antiulcerous and antiinflammatory and has medicinal/pharmacological value. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the antioxidant activities of &lt;em&gt;Asparagus racemosus&lt;/em&gt; root extracts via total phenolic and total flavonoid contents of ethanolic and aqueous extracts. Methods: Antioxidant capacity measurements were carried out by DPPH, ABTS and FRAP methods. Total phenolic and flavonoid contents were determined by the Folin-Ciocalteu method and the aluminum chloride colorimetric method, respectively. &lt;strong&gt;Results:&lt;/strong&gt; The ethanolic extract possessed higher antioxidant capacities than the aqueous extract in the three antioxidant assays (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05).These results have shown high phenolic and flavonoid contents. The ethanolic extract of AR root possessed higher amounts of phenolic and flavonoid contents than the aqueous extract.&lt;strong&gt; Conclusion:&lt;/strong&gt; The antioxidant capacity of the ethanolic extract was higher than that in the aqueous extract.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ladachart Taepongsorat&lt;sup&gt;1,*&lt;/sup&gt;, Surapong Rattana&lt;sup&gt;2, 3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Mahasarakham 44150, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Science Education, Faculty of Education, Nakhon Phanom University, Nakhon Phanom 48000, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nita Triadisti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of Fractions from Garcinia hombroniana Pierre Leaves Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Column chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Free Radicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometric thin layer chromatography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/650</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">682-685</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Radicals were compounds that generated in normal metabolism and create cell damage. A significant increase of free radical and decreased radical elimination can lead to oxidative stress. Oxidative stress plays an important role in the development of many diseases. Enhanced supply of antioxidants will help prevent the morbidity of many diseases. &lt;em&gt;Garcinia hombroniana&lt;/em&gt; Pierre has potency as an antioxidant, but study to evaluate the active fractions as an antioxidant has not been done. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the study was to evaluate antioxidant activity of fractions separated from ethyl acetate (EtOAc) and methanol (MeOH) extract of &lt;em&gt;Garcinia hombroniana&lt;/em&gt; leaves and to obtain active fractions to facilitate finding a pure antioxidant compound. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was fractionated using column chromatography, while antioxidant activity assay was conducted &lt;em&gt;in vitro&lt;/em&gt; using spectrophotometric methods with DPPH and FRAP method. &lt;strong&gt;Results:&lt;/strong&gt; EtOAc extract of &lt;em&gt;G. hombroniana&lt;/em&gt; leaves yielded EA-8 with radical scavenging percentage 32.67% (10 ppm, with DPPH method) and EA-11 with antioxidant activity percentage 25.73% (10 ppm, with FRAP method) as the most active fraction from EtOAc extract, while MeOH extract yielded M-3 with radical scavenging percentage 37.42% (10 ppm, with DPPH method) and 26.70% (10 ppm, with FRAP method) as the most active fraction from MeOH extract &lt;strong&gt;Conclusion:&lt;/strong&gt; Most active fractions has good antioxidant activity, worthy for further study to isolate antioxidant compound which is responsible for antioxidant activity. However, the percentage of radical scavenging or antioxidant activity of all active fractions were smaller than quercetin as a positive control.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nita Triadisti&lt;sup&gt;1,2&lt;/sup&gt;*, Rani Sauriasari&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia 16424, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Muhammadiyah Banjarmasin, 70114, Banjarmasin, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanveer Bilal Pirzadah</style></author><author><style face="normal" font="default" size="100%">Bisma Malik</style></author><author><style face="normal" font="default" size="100%">Inayatullah Tahir</style></author><author><style face="normal" font="default" size="100%">Reiaz Ul Rehman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Potential and Ionomic Analysis of Two Buckwheat Species from Kashmir Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aas</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Buckwheat</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Buckwheat in the past had been the staple food for many regions in the Himalaya&amp;rsquo;s and its utilization has declined with time. In recent times buckwheat gained a lot of attention as it has been placed in the list of underutilized crops by FAO. There is a strong sentiment and realization for buckwheat revival because of its neutraceutrical properties due to which it provides the consumers with extra choice for his food basket. In this context the present investigation aimed to evaluate the antioxidant potential and mineral element analysis of two buckwheat species grown in Kashmir region. &lt;strong&gt;Methods:&lt;/strong&gt; To achieve this goal, antioxidant potential of two buckwheat species was done by using standard protocols. For ionomic analysis, atomic absorption spectrophotometry (AAS) was done to unravel the macro-and micro-nutrient composition. &lt;strong&gt;Result:&lt;/strong&gt; Aqueous extract of &lt;em&gt;Fagopyrum tataricum&lt;/em&gt; exhibits higher TPC (159.51&amp;plusmn;10.3 mg gallic acid equivalent g-&lt;sup&gt;1&lt;/sup&gt; DW) and TFC (79.49&amp;plusmn;9.76 mg rutin equivalent g-&lt;sup&gt;1&lt;/sup&gt; DW). The &lt;em&gt;F. tataricum&lt;/em&gt; samples exhibit high radical scavenging activity (RSa&lt;sub&gt;50&lt;/sub&gt;=26.67&amp;mu;g ml-&lt;sup&gt;1&lt;/sup&gt;) as compared to &lt;em&gt;F. kashmirianum&lt;/em&gt; (RSa&lt;sup&gt;50&lt;/sup&gt;=34.15&amp;mu;g ml-&lt;sup&gt;1&lt;/sup&gt;). Elemental analysis revealed that calcium (Ca) was found high in &lt;em&gt;F. tataricum&lt;/em&gt; (5125&amp;plusmn;56.76ppm) while as the iron (Fe) and zinc (Zn) were found in high concentration in &lt;em&gt;F. kashmirianum&lt;/em&gt; (1122.5&amp;plusmn;25.77ppm) and (122.75&amp;plusmn;12.34ppm) respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings suggested that buckwheat extract possess excellent antioxidant property and is rich source of minerals indispensable for human health. Thus, buckwheat could be a promising alternative in functional food sector for improving the social well-being and diminishing malnutrition especially for the impoverished community.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Aqueous extract, Antioxidants, AAS, Buckwheat, DPPH, FRAP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tanveer Bilal Pirzadah&lt;sup&gt;1&lt;/sup&gt;, Bisma Malik&lt;sup&gt;1&lt;/sup&gt;, Inayatullah Tahir&lt;sup&gt;1, 2&lt;/sup&gt;, Reiaz Ul Rehman&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tanveer Bilal Pirzadah</style></author><author><style face="normal" font="default" size="100%">Bisma Malik</style></author><author><style face="normal" font="default" size="100%">Inayatullah Tahir</style></author><author><style face="normal" font="default" size="100%">Reiaz Ul Rehman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Potential and Ionomic Analysis of Two Buckwheat Species from Kashmir Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aas</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Buckwheat</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s83-s88</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Buckwheat in the past had been the staple food for many regions in the Himalaya&amp;rsquo;s and its utilization has declined with time. In recent times buckwheat gained a lot of attention as it has been placed in the list of underutilized crops by FAO. There is a strong sentiment and realization for buckwheat revival because of its nutraceutrical properties due to which it provides the consumers with extra choice for his food basket. In this context the present investigation aimed to evaluate the antioxidant potential and mineral element analysis of two buckwheat species grown in Kashmir region. &lt;strong&gt;Methods:&lt;/strong&gt; To achieve this goal, antioxidant potential of two buckwheat species was done by using standard protocols. For ionomic analysis, atomic absorption spectrophotometry (AAS) was done to unravel the macro-and micro-nutrient composition. &lt;strong&gt;Result:&lt;/strong&gt; Aqueous extract of &lt;em&gt;Fagopyrum tataricum&lt;/em&gt; exhibits higher TPC (159.51&amp;plusmn;10.3 mg gallic acid equivalent g-1 DW) and TFC (79.49&amp;plusmn;9.76 mg rutin equivalent g-1 DW). The &lt;em&gt;F.&lt;/em&gt; &lt;em&gt;tataricum&lt;/em&gt; samples exhibit high radical scavenging activity (RSa50=26.67&amp;mu;g ml-1) as compared to &lt;em&gt;F. kashmirianum&lt;/em&gt; (RSa&lt;sub&gt;50&lt;/sub&gt;=34.15&amp;mu;g ml-1). Elemental analysis revealed that calcium (Ca) was found high in &lt;em&gt;F. tataricum&lt;/em&gt; (5125&amp;plusmn;56.76ppm) while as the iron (Fe) and zinc (Zn) were found in high concentration in &lt;em&gt;F. kashmirianum&lt;/em&gt; (1122.5&amp;plusmn;25.77ppm) and (122.75&amp;plusmn;12.34ppm) respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; These findings suggested that buckwheat extract possess excellent antioxidant property and is rich source of minerals indispensable for human health. Thus, buckwheat could be a promising alternative in functional food sector for improving the social well-being and diminishing malnutrition especially for the impoverished community.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s83</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tanveer Bilal Pirzadah&lt;sup&gt;1&lt;/sup&gt;, Bisma Malik&lt;sup&gt;1&lt;/sup&gt;, Inayatullah Tahir&lt;sup&gt;1,2&lt;/sup&gt;, Reiaz Ul Rehman&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raghavendra H.L</style></author><author><style face="normal" font="default" size="100%">Prashith Kekuda T.R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiradical and Lipid Peroxidation Inhibitory Activity of Ripe and Unripe Fruit of Rubus steudneri Schweinf. (Rosaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Free radical</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Maceration</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Rubus steudneri Schweinf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/677</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">818-822</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; A free radical is a molecular species characterized by the presence of an unpaired electron in its outer orbital. Free radicals are highly reactive and are known to damage biomolecules including lipids resulting in a myriad of pathophysiological conditions. The present investigation was carried out to screen antiradical and lipid peroxidation inhibitory activity of ripe and unripe fruit of R. steudneri. &lt;strong&gt;Methods:&lt;/strong&gt; The powdered ripe and unripe fruit materials were extracted by maceration process using methanol. Antiradical activity of extracts was evaluated by DPPH and hydroxyl radical scavenging assays. Lipid peroxidation inhibition assay was carried out by estimating the thiobarbituric acid reactive substances. Both ripe and unripe fruit extracts were screened for the presence of phytochemicals viz. alkaloids, flavonoids, tannins, phenolic compounds, saponins, glycosides, sterols and triterpenoids by standard tests. &lt;strong&gt;Results:&lt;/strong&gt; Preliminary phytochemical analysis indicated that both ripe and unripe fruit extracts contain saponins, alkaloids, phenolic compounds, flavonoids, tannins, sterols and triterpenoids. When compared to unripe fruit extract, ripe fruit extract displayed marked scavenging of DPPH and hydroxyl radicals and inhibition of lipid peroxidation as indicated by lower IC&lt;sub&gt;50&lt;/sub&gt; values. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, ripe fruit extract displayed marked free radical scavenging and lipid peroxidation inhibitory activity. The presence of phenolic and flavonoid compounds in the extracts might be responsible for observed bioactivities of ripe and unripe fruit of &lt;em&gt;R. steudneri&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Short Communication</style></work-type><section><style face="normal" font="default" size="100%">818</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Raghavendra H.L&lt;sup&gt;1*&lt;/sup&gt;, Prashith Kekuda T.R&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, School of Medicine, Wollega University, Nekemte, Ethiopia, EAST AFRICA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S Campus, Balraj Urs Road, Shivamogga, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Christine May Gaylan</style></author><author><style face="normal" font="default" size="100%">John Carlo Estebal</style></author><author><style face="normal" font="default" size="100%">Ourlad Alzeus G. Tantengco</style></author><author><style face="normal" font="default" size="100%">Elena M. Ragragio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Staphylococcal and Antioxidant Properties of Crude Ethanolic Extracts of Macrofungi Collected from the Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Mushrooms</style></keyword><keyword><style  face="normal" font="default" size="100%">Philippines</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/405</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">106-109</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Macrofungi have been used in the Philippines as source of food and traditional medicines. However, these macrofungi in the Philippines have not yet been studied for different biological activities. Thus, this research determined the potential antibacterial and antioxidant activities of crude ethanolic extracts of seven macrofungi collected in Bataan, Philippines. &lt;strong&gt;Methods:&lt;/strong&gt; Kirby-Bauer disk diffusion assay and broth microdilution method were used to screen for the antibacterial activity and DPPH scavenging assay for the determination of antioxidant activity. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;F. rosea, G. applanatum, G. lucidum &lt;/em&gt;and&lt;em&gt; P. pinisitus&lt;/em&gt; exhibited zones of inhibition ranging from 6.55 &amp;plusmn; 0.23 mm to 7.43 &amp;plusmn; 0.29 mm against &lt;em&gt;S. aureus, D. confragosa, F. rosea, G. lucidum, M. xanthopus &lt;/em&gt;and&lt;em&gt; P. pinisitus&lt;/em&gt; showed antimicrobial activities against &lt;em&gt;S. aureus&lt;/em&gt; with an MIC&lt;sub&gt;50&lt;/sub&gt; ranging from 1250 &amp;mu;g/mL to 10000 &amp;mu;g/mL. &lt;em&gt;F. rosea, G. applanatum, G. lucidum, M. xanthopus&lt;/em&gt; exhibited excellent antioxidant activity with &lt;em&gt;F. rosea&lt;/em&gt; having the highest antioxidant activity among all the extracts tested (3.0 &amp;mu;g/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on the results, these Philippine macrofungi showed antistaphylococcal activity independent of the antioxidant activity. These can be further studied as potential sources of antibacterial and antioxidant compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">106</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Christine May Gaylan&lt;sup&gt;1&lt;/sup&gt;, John Carlo Estebal&lt;sup&gt;1&lt;/sup&gt;, Ourlad Alzeus G. Tantengco&lt;sup&gt;2&lt;/sup&gt;, Elena M. Ragragio&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Padre Faura Street, Ermita, Manila, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila, PHILIPPINES.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sweta Bawari</style></author><author><style face="normal" font="default" size="100%">Archana Negi Sah</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiurolithiatic Activity of Daucus carota: An In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aggregation</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FT-IR</style></keyword><keyword><style  face="normal" font="default" size="100%">Nucleation</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">880-884</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Urolithiasis is a polygenic disorder with complex etiology and even complicated treatment outcomes. Daucus carota is a widely cultivated crop with traditional claims for its antiurolithiatic potential. &lt;strong&gt;Aim:&lt;/strong&gt; Present study was an attempt to investigate the antilithic potential of D. carota root extract (DCRE) against calcium oxalate (CaOx) urolithiasis by employing &lt;em&gt;in vitro&lt;/em&gt; methods.&lt;strong&gt; Methods:&lt;/strong&gt; Nucleation, growth and aggregation assay of CaOx crystallization were used. FT-IR analysis was used for characterizing CaOx crystals. &lt;strong&gt;Results:&lt;/strong&gt; DCRE exhibited significant inhibition of nucleation, growth and aggregation of CaOx crystals. It produced a favorable morphological transformation of CaOx crystals from calcium oxalate monohydrate to calcium oxalate dihydrate. FT-IR analysis confirmed formation of calcium oxalate monohydrate crystals to be utilized for growth and aggregation assays. &lt;strong&gt;Conclusion:&lt;/strong&gt; DCRE possesses significant antiurolithiatic activity against CaOx urolithiasis&lt;em&gt; in vitro&lt;/em&gt; which could be attributed to its saponins, tannins, flavonoids and polyphenolic content.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">880</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sweta Bawari, Archana Negi Sah&lt;sup&gt;*&lt;/sup&gt;, Devesh Tewari&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital &amp;ndash; 263136, Uttarakhand, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darshanaa Arunachalam</style></author><author><style face="normal" font="default" size="100%">Sheeja Varghese</style></author><author><style face="normal" font="default" size="100%">Lakshmi Thangavelu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Anti-Protease Property of Nutmeg in Causing Delayed Disintegration of Platelet Rich Fibrin – an in vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Myristica fragrans</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodontal guided tissue regeneration</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodontitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet-rich fibrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteolysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/648</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">672-676</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Platelet-rich fibrin is a second generation platelet concentrate enhances tissue healing and is in predominant use as a barrier membrane in periodontal regeneration. However, a normal PRF membrane has rapid degradability (1-2 weeks). Myristica fragrans (nutmeg) has been found to have antiprotease property. It was hypothesized if this property helps in inhibiting degradation of PRF. &lt;strong&gt;Aim:&lt;/strong&gt; To assess whether nutmeg has any effect in inhibitingdegradability of PRF membrane and to compare the degradability of PRF at different concentrations (200mg, 100mg, 50mg) of ethanolic and crude extracts of nutmeg. &lt;strong&gt;Materials and Methodology:&lt;/strong&gt; PRF was procured from 30 ml blood from 5 different donors were cut to equal sizes into 35 pieces. They were measured at baseline and dropped in 7 sets of ependorphs containing PBS, PBS containing 200 mg, 100mg and 50 mg crude extract of nutmeg, PBS containing 200 mg, 100mg and 50 mg ethanolic extract of nutmeg. After 1 week the PRF were retrieved and measured. The percentage of remaining PRF was calculated and data analysed. &lt;strong&gt;Result:&lt;/strong&gt; It was found that there was a difference in percentages of remaining PRF between all the groups when compared to the control group, out of which, crude extract of nutmeg 200 mg group alone had a significantly lesser % of remaining PRF than the control. All ethanolic extract groups had a significantly greater % of remaining PRF when compared to that of the control. &lt;strong&gt;Conclusion:&lt;/strong&gt; Nutmeg is effective in inhibiting the degradation of PRF membrane.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">672</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Darshanaa Arunachalam&lt;sup&gt;1&lt;/sup&gt;, Sheeja Varghese&lt;sup&gt;2*&lt;/sup&gt;, Lakshmi Thangavelu &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post graduate student, Department of Periodontics,Saveetha Dental College,SIMATS.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Head of the Department,Department of Periodontics, Saveetha Dental College,SIMATS.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Pharmacology,Saveetha Dental College,SIMATS.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kris Herawan Timotius</style></author><author><style face="normal" font="default" size="100%">Adelina Simamora</style></author><author><style face="normal" font="default" size="100%">Adit Widodo Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Characteristics and In vitro Antidiabetic and Antioxidant Activities of Premna serratifolia L. Leaf Infusion and Decoction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">P. serratifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1114-1118</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Leaves of &lt;em&gt;Premna serratifolia&lt;/em&gt; L. (local name: arogo) is well known as food ingredient for fish/meat-based soup in Tentena, Indonesia. Evaluation of its bioactivities is needed. Objective: This study aimed to evaluate the &amp;alpha;-glucosidase inhibitory and antioxidant activities of infusion and decoction of &lt;em&gt;P. serratifolia&lt;/em&gt; leaves.&lt;strong&gt; Methods:&lt;/strong&gt; The leaf samples were prepared by infusion and decoction and analysed for their &amp;alpha;-glucosidase inhibitory and antioxidant activities, as well as total phenolic contents and LC-MS profiles. Results: The total phenolic content of the decoction was higher than the infusion. The UV spectra of both infusion and decoction showed peak at 325 nm and shoulder at 285 nm. Their LC-MS yielded one dominant component at 132 (100) m/z fragment, which was tentatively identified as caffeic acid. Both infusion and decoction extracts exhibited strong &amp;alpha;-glucosidase inhibition with IC&lt;sub&gt;50&lt;/sub&gt; of 4.27 and 0.046 &amp;mu;g GAE/ml, respectively. The IC&lt;sub&gt;50&lt;/sub&gt; for DPPH scavenging activity of the infusion and decoction were similar; 6.82 and 7.28 &amp;mu;g GAE/ml, respectively. But the IC&lt;sub&gt;50&lt;/sub&gt; of the infusion and decoction for ferrous ion chelating activities were different; 161.66 and 28.34 &amp;mu;g GAE/ ml, respectively. The &amp;alpha;-glucosidase inhibitory and antioxidant activities were related to the phenolic content. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study concludes that both infusion and decoction of arogo leaves have antidiabetic effect and potential antioxidant activity. The decoction of the leaves may increase its antidiabetic capacity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1114</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kris Herawan Timotius&lt;sup&gt;1,&lt;/sup&gt;*, Adelina Simamora&lt;sup&gt;1&lt;/sup&gt;, Adit Widodo Santoso&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 11510, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Herbal Medicine, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 11510, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s129-s134</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on Paracetamol-induced liver toxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetamol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 56.17%, 54.53%, 61.55% 57.29% and 53.66%.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in &lt;em&gt;S. officinalis&lt;/em&gt; and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s129</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna&lt;/strong&gt;&lt;strong&gt; Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2,*&lt;/sup&gt;, Ganga Rao Battu&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anacipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mallikarjuna Rao Talluri</style></author><author><style face="normal" font="default" size="100%">Veda Priya Gummadi</style></author><author><style face="normal" font="default" size="100%">Ganga Rao Battu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Hepatoprotective Activity of Saponaria officinalis on Paracetamol-induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponaria officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1196-1201</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The present day life style causing different illness including liver diseases and different health complications. So, there is a need to identify new chemical entities with more efficiency in the treatment of diseases and less side effects. There were many reports in recent times, about identifying new drugs from different medicinal plants and also precursors for synthesis new bioactive molecules for treating various diseases. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was carried out on root parts (rhizomes) of &lt;em&gt;S. officinalis&lt;/em&gt; for phytochemical analysis and hepatoprotective activity on paracetmol-induced liver toxicity. Materials and methods: The phytochemical analysis was carried out to know biological active compounds in different extracts of &lt;em&gt;S. officinalis&lt;/em&gt; using standard procedures and quantified the total alkaloid and phenolic contents. Hepatoprotective activity of the &lt;em&gt;S. officinalis&lt;/em&gt; extracts were carried out by using Paracetmol-induced hepatotoxicity in rats. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical analysis of &lt;em&gt;S. officinalis&lt;/em&gt; roots&amp;rsquo; extracts showed presence of sterols, terpenoids, glycosides, carbohydrates, proteins, flavanoids, alkaloids, phenols, tannins and absence of saponins and oils. The methanolic extract showed more phenolic and alkaloid contents on their quantification. The &lt;em&gt;S. officinalis&lt;/em&gt; roots extracts are found to be safe at 2000 mg/kg b. w. in acute toxicity study and showed dose dependent percentage protection on liver toxicity. Methanol extract showed more activity at 500mg/kg b. w. and is comparable with standard drug Liv 52 on altered liver biomarker enzymes AST (SGOT), ALT (SGPT), ALP, total bilirubin and total protein with percentage protection 66.67%,60.63%,65.93%,64.24% and 60.98%. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study results indicates that phytochemical constituent&amp;rsquo;s diversity in S. officinalis and those extracts possess hepatoprotective activity. Further studies are needed and should involve the isolation of pure, biologically active compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1196</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mallikarjuna Rao Talluri&lt;sup&gt;1&lt;/sup&gt;, Veda Priya Gummadi&lt;sup&gt;2&lt;/sup&gt;,*, Ganga Rao Battu&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;AnaCipher Clinical Research Organization, Ramanthapur, Hyderabad, Telangana-500013, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;AU College of Pharmaceutical Science, Andhra University, Visakhapatnam, Andhra Pradesh-530003, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarah Zielda Najib</style></author><author><style face="normal" font="default" size="100%">Wilzar Fachri</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Raymond Tjandrawinata</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cholesterol-lowering Effects of Extract from Garcinia daedalanthera in Hyperlipidemic rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">In vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Pre-clinical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1125-1128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; A native plant from Indonesia, &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; can modulate the lipid profiles of hyperlipidemic rats. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to evaluate the antihyperlipidemic potential of &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract which serves as a new potential natural product for preventing hyperlipidemia.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1125</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sarah Zielda Najib&lt;sup&gt;1&lt;/sup&gt;,&amp;nbsp;Wilzar Fachri&lt;sup&gt;2&lt;/sup&gt;,&amp;nbsp;Rani Sauriasari&lt;sup&gt;1&lt;/sup&gt;*,&amp;nbsp;Berna Elya&lt;sup&gt;1&lt;/sup&gt;, Raymond Tjandrawinata&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, University of Indonesia, Salemba, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Dexa Laboratories of Biomolecular Sciences, Cikarang, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sewan Theeramunkong</style></author><author><style face="normal" font="default" size="100%">Maleeruk Utsintong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between Volatile Oil from Fresh and Dried Fruits of Zanthoxylum rhetsa (Roxb.) DC. and Cytotoxicity Activity Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Local variation</style></keyword><keyword><style  face="normal" font="default" size="100%">Volatile oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Zanthoxylum rhetsa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">827-832</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Zanthoxylum rhetsa&lt;/em&gt; is a tree found in northern Thailand. It has been used as a traditional herb with medicinal properties. However, the comparison of composition in volatile oil from fresh and dried fruit is still not fully investigated. In study, we evaluated the constituents in oil from fruits of&lt;em&gt; Z. rhetsa&lt;/em&gt; and evaluated the cytotoxicity in non-small lung cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The hydro distillation was applied to afford the oil. The obtained oil was analyzed by GC-MS and evaluated the cytotoxicity and apoptosis in non-small lung cells by using MTT method and flow cytometry respectively. &lt;strong&gt;Results:&lt;/strong&gt; Fresh and dried fruits provided a higher yield of volatile oil by approximately 10% and 20% respectively, compared to other studies. Twenty-eight compounds were identified and the major components of fresh and dried fruits were not distinctly different. The major component, &amp;alpha;-limonene, was found in dried fruits from Phayao, southern Nan and Chiang Rai province. A high content of &amp;beta;-phellandrene was found in dried fruits from northern Nan province and the (+)-sabinene was found in high content of fresh fruits from southern Nan, Phayao and Chaing Rai province. Furthermore, the cytotoxicity tests displayed that all of oil products were active against lung cancer cells. Among the components investigated, fresh and dried fruits from southern Nan province showed to be the most potent (EC&lt;sub&gt;50&lt;/sub&gt; = 1.91 &amp;plusmn; 0.53, 1.79 &amp;plusmn; 0.43 &amp;mu;L/mL, respectively). &lt;strong&gt;Conclusion:&lt;/strong&gt; Volatile oil of &lt;em&gt;Z. rhetsa&lt;/em&gt; exhibited a strong cytotoxic properties against cytotoxic may be potentially used as natural anticancer agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">827</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sewan Theeramunkong&lt;sup&gt;1&lt;/sup&gt;, Maleeruk Utsintong&lt;sup&gt;2&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Thammasat University, 99 Moo 18 Phahonyothin Road, Klongluang, Pathumthani, 12120, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Pharmaceutical Sciences, University of Phayao, 19 Moo 2 Lumpang-Phayao Road, Mueang, Phayao 56000, THAILAND&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sewan Theeramunkong</style></author><author><style face="normal" font="default" size="100%">Maleeruk Utsintong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between Volatile Oil from Fresh and Dried Fruits of Zanthoxylum rhetsa (Roxb.) DC. and Cytotoxicity Activity Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-78</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">Sewan Theeramunkong,1 Maleeruk Utsintong,2*

1Faculty of Pharmacy, Thammasat University, 99 Moo 18 Phahonyothin Road, Klongluang, Pathumthani, 12120, THAILAND.

2School of Pharmaceutical Sciences, University of Phayao, 19 Moo 2 Lumpang-Phayao Road, Mueang, Phayao 56000, THAILAND.</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sewan Theeramunkong</style></author><author><style face="normal" font="default" size="100%">Maleeruk Utsintong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between Volatile Oil from Fresh and Dried Fruits of Zanthoxylum rhetsa (Roxb.) DC. and Cytotoxicity Activity Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal,</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-78</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Zanthoxylum rhetsa&lt;/em&gt; is a tree found in northern Thailand. It has been used as a traditional herb with medicinal properties. However, the comparison of composition in volatile oil from fresh and dried fruit is still not fully investigated. In study, we evaluated the constituents in oil from fruits of &lt;em&gt;Z. rhetsa&lt;/em&gt; and evaluated the cytotoxicity in non-small lung cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The hydro distillation was applied to afford the oil. The obtained oil was analyzed by GC-MS and evaluated the cytotoxicity and apoptosis in non-small lung cells by using MTT method and flow cytometry respectively. &lt;strong&gt;Results:&lt;/strong&gt; Fresh and dried fruits provided a higher yield of volatile oil by approximately 10% and 20% respectively, compared to other studies. Twenty-eight compounds were identified and the major components of fresh and dried fruits were not distinctly different. The major component, &amp;alpha;-limonene, was found in dried fruits from Phayao, southern Nan and Chiang Rai province. A high content of &amp;beta;-phellandrene was found in dried fruits from northern Nan province and the (+)-sabinene was found in high content of fresh fruits from southern Nan, Phayao and Chaing Rai province. Furthermore, the cytotoxicity tests displayed that all of oil products were active against lung cancer cells. Among the components investigated, fresh and dried fruits from southern Nan province showed to be the most potent (EC&lt;sub&gt;50&lt;/sub&gt; = 1.91 &amp;plusmn; 0.53, 1.79 &amp;plusmn; 0.43 &amp;mu;L/mL, respectively). &lt;strong&gt;Conclusion:&lt;/strong&gt; Volatile oil of &lt;em&gt;Z. rhetsa &lt;/em&gt;exhibited a strong cytotoxic properties against cytotoxic may be potentially used as natural anticancer agents. &lt;strong&gt;Key words:&lt;/strong&gt; &lt;em&gt;Zanthoxylum rhetsa&lt;/em&gt;, Local variation, Volatile oil, Chemical composition, Cytotoxic activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sewan Theeramunkong,&lt;sup&gt;1&lt;/sup&gt; Maleeruk Utsintong,&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;1Faculty of Pharmacy, Thammasat University, 99 Moo 18 Phahonyothin Road, Klongluang, Pathumthani, 12120, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;2School of Pharmaceutical Sciences, University of Phayao, 19 Moo 2 Lumpang-Phayao Road, Mueang, Phayao 56000, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Veerale Panchal</style></author><author><style face="normal" font="default" size="100%">Deepa Gurunathan</style></author><author><style face="normal" font="default" size="100%">Lakshmi Thangavelu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Antibacterial Efficacy of Cinnamon Extract and Calcium Hydroxide as Intracanal Medicament against E. fecalis: An In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial efficacy</style></keyword><keyword><style  face="normal" font="default" size="100%">Calcium hydroxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamon extract</style></keyword><keyword><style  face="normal" font="default" size="100%">E. feacalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Intracanal medicament</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1165-1168</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There has been an increased use of natural products as medicament in endodontic treatment due to the increased adverse effect observed in chemical products used. The natural products used aims to disinfect the root canal and provide a sterile environment as efficiently as the comparable chemical products. &lt;strong&gt;Aim:&lt;/strong&gt; To compare the antibacterial efficacy of cinnamon extract and calcium hydroxide as intracanal medicament against &lt;em&gt;E. fecalis.&lt;/em&gt; &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The study is an &lt;em&gt;in vitro&lt;/em&gt; randomized controlled study conducted on 40 single rooted permanent teeth. The study sample was divided into two groups- cinnamon extract as intracanal medicament and calcium hydroxide. The intracanal medicament was placed for 7 days. The outcome was measures using colony forming units per ml. Statistical analysis was done using Mann-Whitney&amp;rsquo;s test to compare between the two groups. &lt;strong&gt;Results:&lt;/strong&gt; Cinnamon extract intracanal medicament showed higher antibacterial efficacy as compared to calcium hydroxide. (p=0.002). &lt;strong&gt;Conclusion:&lt;/strong&gt; Cinnamon extract showed better antimicrobial efficacy against &lt;em&gt;E. feacalis&lt;/em&gt; as intracanal medicament as compared to calcium hydroxide.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">xx1165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Veerale Panchal&lt;sup&gt;1&lt;/sup&gt;, Deepa Gurunathan&lt;sup&gt;1,*&lt;/sup&gt;, Lakshmi Thangavelu &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pediatric and Preventive Dentistry. Saveetha Dental College. Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology. Saveetha Dental College. Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A. indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">M. pudica</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai folklore recipe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/512</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">480-485</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Abutilon indicum&lt;/em&gt; and &lt;em&gt;Mimosa pudica&lt;/em&gt; were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. &lt;strong&gt;Aims:&lt;/strong&gt; The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The recipe were composed of whole plants from &lt;em&gt;A. indicum&lt;/em&gt; and &lt;em&gt;M. Pudica&lt;/em&gt; (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extracts were showed significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">480</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ampa Konsue&lt;sup&gt;1*&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Sciences, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A. indicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose.</style></keyword><keyword><style  face="normal" font="default" size="100%">M. pudica</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai folklore recipe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">x</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Abutilon indicum&lt;/em&gt; and &lt;em&gt;Mimosa pudica&lt;/em&gt; were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. &lt;strong&gt;Aims:&lt;/strong&gt; The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The recipe were composed of whole plants from &lt;em&gt;A. indicum&lt;/em&gt; and &lt;em&gt;M. Pudica&lt;/em&gt; (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extracts were showed significantly (p&amp;lt;0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p&amp;lt;0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt; 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p&amp;lt; 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Thai folklore recipe, A. indicum , M. pudica , Fasting blood glucose.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">x</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ampa Konsue&lt;sup&gt;1*&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Sciences, Mahasarakham University, Maha Sarakham, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ladachart Taepongsorat</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Asparagus racemosus Root Extracts on Serum Lipid Profiles, Lipid Peroxidation and Superoxide Dismutase in Ovariectomized Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asparagus racemosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid profiles</style></keyword><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Ovariectomized rat</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1036-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Once rats have been ovariectomized they have a high risk of cardiovascular disease due to changes in the blood cholesterol and lipid profile. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the effects of &lt;em&gt;Asparagus racemosus&lt;/em&gt; (AR) root extract on the serum lipid profiles, lipid peroxidation and antioxidant levels in ovariectomized rats. &lt;strong&gt;Methods:&lt;/strong&gt; Twenty-five, two month-old female Wistar rats were randomly divided into five groups: SH, OVX,OEE, OAAR and OEAR. The daily doses of 500 mg/KgBW of the AR root extracts for five weeks.The levels of serum TG, TC, HDL, LDL, the liver, kidney and uterine tissue lipid peroxidation and SOD levels were determined. &lt;strong&gt;Results:&lt;/strong&gt; Serum TC and LDL showed no significant differences in any groups. Serum TG of the OAAR and OEAR groups were not significantly different. The serum HDL of the OAAR and OEAR groups were significantly lower than the OEE group. The liver MDA levels of the OAAR and OEAR groups were significantly decreased compared with the OVX and OEE groups while the SOD level of the OAAR group was significantly increased. The MDA levels in the kidney and uterine of the treated group showed no significant difference. The SOD levels in the kidney of the treated group were not different but the SOD levels in uterine were significantly decreased. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be believed that the lipid profiles were maybe regulated via estrogen.The AR extract has low effects on the lipid profiles at this dose and duration of treatment. The capacity of the extracts to decrease the MDA level and increase the SOD level in this study clearly reflected the antioxidant efficiency of these substances.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1036</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ladachart Taepongsorat&lt;sup&gt;1*&lt;/sup&gt;, Methin Phadungkit&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry and Natural Products Research Unit, Faculty of Pharmacy, Mahasarakham University, Mahasarakham 44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ourlad Alzeus G. Tantengco</style></author><author><style face="normal" font="default" size="100%">MARLON LIAN C. CONDES</style></author><author><style face="normal" font="default" size="100%">Hanna Hasmini T. Estadilla</style></author><author><style face="normal" font="default" size="100%">Elena M. Ragragio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Survey of Medicinal Plants used by Ayta Communities in Dinalupihan, Bataan, Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ayta</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Philippines</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">859-870</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This study documented the species of medicinal plants used by Ayta communities in Dinalupihan, Bataan. The plant parts used for medicinal purposes, preparations, mode of administration of these medicinal plants were determined. The most important species based on use values and informant consensus factors were also calculated.&lt;strong&gt; Methods:&lt;/strong&gt; A total of 26 informants were interviewed regarding the plants they utilize for medicinal purposes. Free and prior informed consents were obtained from the informants. Taxonomic identification was done in the Botany Division of the National Museum of the Philippines. Informant consensus factor (FIC) and use values (UV) were also calculated. &lt;strong&gt;Results:&lt;/strong&gt; Ayta communities listed a total of 118 plant species classified into 49 families used as herbal medicines. The Family &lt;em&gt;Fabaceae&lt;/em&gt; was the most represented plant family with 11 species. Leaves were the most used plant part (43%). Majority of medicinal preparations were taken orally (57%). It was found that &lt;em&gt;Psidium guajava L.&lt;/em&gt; and &lt;em&gt;Lunasia amara&lt;/em&gt; Blanco were the most commonly used medicinal plants in the three communities with the use value of 0.814. &lt;strong&gt;Conclusion:&lt;/strong&gt; This documentation provides a catalog of useful plants of the Ayta and serves as a physical record of their culture for the education of future Ayta generations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">859</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ourlad Alzeus G. Tantengco&lt;sup&gt;1*&lt;/sup&gt;, Marlon Lian C. Condes&lt;sup&gt;2&lt;/sup&gt;, Hanna Hasmin T. Estadilla&lt;sup&gt;2&lt;/sup&gt;, Elena M. Ragragio&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Medicine, University of the Philippines Manila, Pedro Gil Street, Ermita, Manila City, Philippines, 1000&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, College of Arts and Sciences, University of the Philippines Manila, Padre Faura St., Ermita, Manila City, Philippines, 1000.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asiya Ramzan</style></author><author><style face="normal" font="default" size="100%">Inayatullah Tahir</style></author><author><style face="normal" font="default" size="100%">Reiaz Ul Rehman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antioxidant Potential of Amaranthus caudatus L. Grown in Kashmir Region</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amaranthus</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrogen peroxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1119-1124</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants have a well-developed defensive machinery for minimizing the reactive oxygen species (ROS) associated damages in the form of enzymatic and nonenzymatic antioxidants. The &lt;em&gt;in-vitro&lt;/em&gt; mechanism of antioxidant action of plant extracts may involve direct inhibition of the ROS generation or ROS scavenging. The antioxidant activity of the extracts may be due to active constituents alone or the combination of constituents. However, the amount of constituents are known to vary according to the change in environment. &lt;strong&gt;Method:&lt;/strong&gt; In our study, antioxidant activity of &lt;em&gt;Amaranthus caudatus&lt;/em&gt; L. from two different sites (elevation sites) was investigated at three stages, (vegetative, pre flowering and post flowering) using ethanolic extract (EtOH). &lt;strong&gt;Result:&lt;/strong&gt; The phenolic and flavonoid content increased at all stages from site 1 to site 2. The total reducing power, Ferrous reducing antioxidative power (FRAP), diphenyl picryl hydrazine (DPPH) radical scavenging assay, superoxide dismutase scavenging (SOD) assay and hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) scavenging activity increased from site 1 to site 2 at all the three stages. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results reveal that the altitude and the growth stage have a significant effect on antioxidative potential of&lt;em&gt; Amaranthus.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Asiya Ramzan&lt;sup&gt;1&lt;/sup&gt; Inayatullah Tahir&lt;sup&gt;2&lt;/sup&gt; Reiaz Ul Rehman&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir- 190006, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir- 190006, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Parameswari Royapuram Parthasarathy</style></author><author><style face="normal" font="default" size="100%">Janani Murthy</style></author><author><style face="normal" font="default" size="100%">Dinesh Murugan Girija</style></author><author><style face="normal" font="default" size="100%">Srivani Telapolu</style></author><author><style face="normal" font="default" size="100%">Chamundeeswari Duraipandian</style></author><author><style face="normal" font="default" size="100%">Thyagarajan Sadras Panchatcharam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hydroalcoholic and Alkaloidal Extracts of Murraya koenigii(L.) Spreng Augments Glucose Uptake Potential against Insulin Resistance Condition in L6 Myotubes and Inhibits Adipogenesis in 3T3L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">complications</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">glucose uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">L6 myotubes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mahanine</style></keyword><keyword><style  face="normal" font="default" size="100%">α - amylase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/642</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">633-639</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Murraya koenigii&lt;/em&gt;, commonly known as &amp;ldquo;curry leaves&amp;rdquo; is native to India. The highly valued part of the plant is the leaves which possess various biological activities. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to investigate the antidiabetic effect of &lt;em&gt;Murraya koenigii&lt;/em&gt; (MK) leaf extracts, of two different solvent ratios. &lt;strong&gt;Materials and methods:&lt;/strong&gt; 70% hydroalcoholic and alkaloidal extracts of MK leaves were prepared by cold maceration method. Preliminary phytochemical analysis was carried out for both the extracts. &lt;em&gt;In vitro&lt;/em&gt; anti diabetic activity was screened by inhibitory action on &amp;alpha; &amp;ndash; amylase, &amp;alpha; &amp;ndash; glucosidase enzymes. Further, the 70% hydroalcoholic and alkaloidal extracts were assessed for glucose uptake potential, anti - adipogenic property, as well as inhibitory activity on diabetes associated complications. HPTLC quantification of major phytoconstituent was carried out. &lt;strong&gt;Results:&lt;/strong&gt; The study showed presence of various phytoconstituents such as, polyphenols, alkaloids, tannins, reducing sugars etc. The 70% hydroalcoholic and alkaloidal extracts of MK leaves exhibited &amp;gt;90% inhibition against carbohydrate metabolising enzymes compared to aqueous and absolute alcohol extracts. Both the extracts showed enhanced glucose uptake in L6 myotubes attenuating the effect of Palmitate induced insulin resistance. Significant inhibition on adipogenesis was exerted by both 70% hydroalcoholic and alkaloidal extracts of MK leaves. Besides, marked inhibition of advanced glycation end products was exhibited by the extracts. HPTLC quantification analysis of the aforementioned extracts showed the presence of major phytoconstituent, Mahanine, in it. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of the present study showed that MK possesses significant antidiabetic property and also exhibited considerable effect in preventing diabetes associated complications. The potent antidiabetic activity of MK could be attributed to the presence of Mahanine, the major active constituent, which is a carbazole alkaloid.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">633</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Parameswari Royapuram Parthasarathy&lt;sup&gt;1&lt;/sup&gt;, Janani Murthy&lt;sup&gt;1&lt;/sup&gt;, Dinesh Murugan Girija&lt;sup&gt;1&lt;/sup&gt;, Srivani Telapolu&lt;sub&gt;1&lt;/sub&gt;, Chamundeeswari Duraipandian&lt;sup&gt;2&lt;/sup&gt;, Thyagarajan Sadras Panchatcharam&lt;sup&gt;3&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;SRMC Centre for Indian Systems of Medicine, Quality assurance and Standardization, Central Research Facility, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Central Research Facility, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii</style></keyword><keyword><style  face="normal" font="default" size="100%">docking simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">leptin receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">olfactory system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">875-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice Balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">875</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation And In Vivo Effect of Essential Oil From Cinnamommum Burmannii as Antiobesity With Leptin Receptor In The Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt; olfactory system, leptin receptors, &lt;em&gt;Cinnamomum burmannii&lt;/em&gt;, docking simulation, immunohistochemistry&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi,1 Aryo Tedjo,&lt;sup&gt;2&lt;/sup&gt; Fadilah Fadilah,&lt;sup&gt;2&lt;/sup&gt; Ade Arsianti,&lt;sup&gt;2&lt;/sup&gt; Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA. *e-mail : fika.paramita@gmail.com / rafikaindah@ ui.ac.id&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramesh Toolabi</style></author><author><style face="normal" font="default" size="100%">Mohammad Reza Abai</style></author><author><style face="normal" font="default" size="100%">Mohammad Mehdi Sedaghat</style></author><author><style face="normal" font="default" size="100%">Hassan Vatandoost</style></author><author><style face="normal" font="default" size="100%">Mansooreh Shayeghi</style></author><author><style face="normal" font="default" size="100%">Saeed Tavakoli</style></author><author><style face="normal" font="default" size="100%">Mohammad Sistanizadeh Aghdam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Larviciding Activity of Acroptilon repens Extract against Anopheles stephensi, Culex pipiens and Culex quinquefaciatus under Laboratory Conditions</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acroptilon repens</style></keyword><keyword><style  face="normal" font="default" size="100%">Anopheles stephensi</style></keyword><keyword><style  face="normal" font="default" size="100%">Culex pipiens</style></keyword><keyword><style  face="normal" font="default" size="100%">Cx. quinquefaciatus</style></keyword><keyword><style  face="normal" font="default" size="100%">Larvicidal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Total extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/507</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">453-456</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Due to the emergence of insecticide resistance among the vectors of human diseases, there is a need to explore the use of plant extracts which are safe alternatives to conventional chemical larvicides used in control of vector-borne diseases. The aim of this study was to evaluate the larvicidal activity of &lt;em&gt;Acroptilon repens&lt;/em&gt; against third instar larvae of &lt;em&gt;Anopheles stephensi, Culex pipiens and Culex quinquefaciatus&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The aerial parts of &lt;em&gt;A. repens&lt;/em&gt; plants was dried in the shaded places for 3 days at 26-28&amp;deg;C. The leaves, flowers and stems were blended to crashed form using an electric blender. The larvicidal activity of total extract of &lt;em&gt;A. repens&lt;/em&gt; were evaluated against third instar larvae stage of mosquito vectors, &lt;em&gt;An. stephensi&lt;/em&gt;, &lt;em&gt;Cx. pipiens&lt;/em&gt; and &lt;em&gt;Cx. quinquefaciatus&lt;/em&gt; under laboratory conditions with 24h exposure period. Data were subjected to probit regression analysis in order to estimate the lethal concentrations for 50% and 90% mortality values. &lt;strong&gt;Result:&lt;/strong&gt; The extract of &lt;em&gt;A. repens&lt;/em&gt; exhibited significant larvicidal activity against third instar larvae of &lt;em&gt;An. stephensi&lt;/em&gt;, with 24h LC&lt;sub&gt;50&lt;/sub&gt; of 0.2970 and LC&lt;sub&gt;90&lt;/sub&gt; of 2.2097 mg/l. The LC&lt;sub&gt;50&lt;/sub&gt; and LC&lt;sub&gt;90&lt;/sub&gt; values were 2.5047 and 24.7374 mg/l for &lt;em&gt;Cx. pipiens&lt;/em&gt; and 2.9047 and 16.1459 mg/l for &lt;em&gt;Cx. quinquefaciatus&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The extract of &lt;em&gt;A. repens&lt;/em&gt; can serve as a natural larvicide against &lt;em&gt;An. stephensi&lt;/em&gt;, &lt;em&gt;Cx. pipiens&lt;/em&gt; and &lt;em&gt;Cx.quinquefaciatus&lt;/em&gt;. According to the larvicidal properties of this plant, formulating an extract of &lt;em&gt;A. repens&lt;/em&gt; which is known as an abundant agricultural weed in Iran creates an alternative to chemical larvicides and providing a job opportunities.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">453</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramesh Toolabi&lt;sup&gt;1&lt;/sup&gt;, Mohammad Reza Abai&lt;sup&gt;1*&lt;/sup&gt;, Mohammad Mehdi Sedaghat&lt;sup&gt;1&lt;/sup&gt;, Hassan Vatandoost&lt;sup&gt;1&lt;/sup&gt;, Mansooreh Shayeghi&lt;sup&gt;1&lt;/sup&gt;, Saeed Tavakoli&lt;sup&gt;2&lt;/sup&gt;, Mohammad Sistanizadeh Aghdam&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical Sciences, Tehran, IRAN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IRAN.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nair Aiswarya</style></author><author><style face="normal" font="default" size="100%">Rao Rashmi R</style></author><author><style face="normal" font="default" size="100%">Shenoy Preethi J</style></author><author><style face="normal" font="default" size="100%">Vinod Chandran</style></author><author><style face="normal" font="default" size="100%">S Teerthanath</style></author><author><style face="normal" font="default" size="100%">Pai Sunil B</style></author><author><style face="normal" font="default" size="100%">KB Rakesh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Effect of Aqueous Extract of Pimpinella anisum in Gentamicin Induced Nephrotoxicity in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aniseed</style></keyword><keyword><style  face="normal" font="default" size="100%">Drug induced nephrotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Pimpinella anisum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/532</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">403-407</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Pimpinella anisum&lt;/em&gt; known for its various medicinal properties is also a natural antioxidant and a free radical scavenger with no documented evidence as a nephroprotective agent. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the nephroprotective activity of aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds in a rodent model of gentamicin induced nephrotoxicity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Wistar albino rats of either sex, weighing 150&amp;ndash;200 g was divided into 5 groups; normal saline, gentamicin 80mg/kg, intraperitoneally for 8 days, aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; seeds at 1, 2, and 4g/kg, per oral for 8 days, the test extract administered 3 days prior and concurrently with gentamicin for 5 days. Blood urea, serum creatinine, uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed. &lt;strong&gt;Results:&lt;/strong&gt; Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in serum urea, serum uric acid, serum creatinine and blood urea nitrogen (107.5&amp;plusmn;16.92mg/dl, 0.8&amp;plusmn;0.09 mg/dl, 3.05&amp;plusmn;0.29 mg/dl, 47.8&amp;plusmn;9.07 mg/dl) respectively when compared to the saline treated groups. Co-administration of &lt;em&gt;Pimpinella anisum&lt;/em&gt; extract with gentamicin decreased the rise in these parameters in a dose dependent manner. Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; mitigated the severity of gentamicin-induced renal damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; To conclude, our data suggest that aqueous extract of &lt;em&gt;Pimpinella anisum&lt;/em&gt; exhibits renoprotective effect in gentamicin induced renal damage and further studies on its mechanism of action are warranted.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">403</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nair Aiswarya&lt;sup&gt;1&lt;/sup&gt;, Rao Rashmi R&lt;sup&gt;1*&lt;/sup&gt;, Shenoy Preethi J&lt;sup&gt;1&lt;/sup&gt;, Vinod Chandran&lt;sup&gt;2&lt;/sup&gt;, S Teerthanath&lt;sup&gt;3&lt;/sup&gt;, Pai Sunil B&lt;sup&gt;1&lt;/sup&gt;, KB Rakesh&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, K S Hegde Medical Academy, Nitte University, Deralakatte, Mangalore, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Debasish Pradhan</style></author><author><style face="normal" font="default" size="100%">Toffa Dasmohapatra</style></author><author><style face="normal" font="default" size="100%">Gitanjali Tripathy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation of Curcumin on Diabetic Retinopathy in Alloxan-induced Diabetes through NF-KB and Brn3a Related Mechanism</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brn3a</style></keyword><keyword><style  face="normal" font="default" size="100%">CaKMII</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">NF-KB</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/486</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">324-332</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetic retinopathy is one of the most common micro vascular complication of diabetes and involves an abnormal pathology of major retinal pigment epithelium, inter retinal oedema and intraocular neovascularisation where pro-inflammatory proteins including ICAM-1,iNOS and VEGF release by activation of enzyme CaMKII/NF-kB expression Diabetic induced oxidative stress followed by deactivation of Brn3a expression in the retinal ganglionic cells are also early events in pathogenesis of Diabetic retinopathy. These factors are important contributors to the development of clinically significant diabetic retinopathy. &lt;strong&gt;Objective:&lt;/strong&gt; Objective of this study to examine the effect of curcumin with antioxidant and anti-inflammatory properties obtained from &lt;em&gt;Curcuma longa&lt;/em&gt; against diabetes-induced retinal vascular damage and its mechanism of action by &lt;em&gt;in-vivo&lt;/em&gt; in retinas of rat rendered diabetic by alloxan and &lt;em&gt;in vitro&lt;/em&gt; in western blotting and RGC tissue culture. &lt;strong&gt;Method:&lt;/strong&gt; We administered curcumin or saline vehicle to experimental animals daily for 12 weeks. Vascular permeability, expression of CaMK II/NF-kB, Retinal morphology and neuropathic change of the retinal ganglion cells were investigated. &lt;strong&gt;Results:&lt;/strong&gt; As an anti-oxidant, curcumin raised Retinal Ganglionic cells by increasing Brn3a expression during oxidative stress condition and subsequently decreased the expression of inflammatory mediators such as VEGF, iNOS and ICAM-1 as an anti-inflammatory agent by inhibiting CaMKII and NF-kB expression. &lt;strong&gt;Conclusion:&lt;/strong&gt; Curcumin, a common food additive has beneficial effects in experimental studies of diseases that are characterised by increased oxidative stress and inflammatory reactions. It appears to be a useful adjunct therapy to possibly inhibit the progression of retinopathy, sight threatening complication faced by diabetic patients.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">324</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Debasish Pradhan&lt;sup&gt;1*&lt;/sup&gt;, Toffa Dasmohapatra&lt;sup&gt;2&lt;/sup&gt;, Gitanjali Tripathy&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Sciences,Creighton University, Carlifornia Plaza,Omaha,NE68102, USA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences,Utkal University, Odisha, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department Of Pharmacy, Government Polytechnic, Chandrashekharpur, Odisha, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gengqiu Tang</style></author><author><style face="normal" font="default" size="100%">Xiaojing Lin</style></author><author><style face="normal" font="default" size="100%">Xiudi Lai</style></author><author><style face="normal" font="default" size="100%">Xue Gong</style></author><author><style face="normal" font="default" size="100%">Shengguo Ji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Studies of Psychotria rubra(Lour.)Poir.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacog Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Identification</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Poir</style></keyword><keyword><style  face="normal" font="default" size="100%">Psychotria rubra(Lour.)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January-2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/474</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">249-255</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Various traditional systems of medicine enlightened the importance of &lt;em&gt;Psychotria rubra&lt;/em&gt; (Lour.) Poir to have a great medicinal value. The present study was carried out to provide a scientific basis of the identification and the authenticity of &lt;em&gt;Psychotria rubra &lt;/em&gt;(Lour.) Poir with the help of pharmacognostic parameters, which is not done before. &lt;strong&gt;Methods:&lt;/strong&gt; Roots, stems, and leaves of &lt;em&gt;P. rubra were&lt;/em&gt; collected for Pharmacognostic studies involving macros, microscopic evaluation, histochemistry and physicochemical parameters analysis like Ash value, Moisture content, Fluorescence analysis and Thin Layer Chromatography&lt;em&gt; et al&lt;/em&gt;.&lt;strong&gt; Results:&lt;/strong&gt; Transverse section of root was found like stone cells, calcium oxalate crystal and vessels in circular shape. Transverse section of stem showed the presence of lenticels and stone cell bands. Transverse section of leaf vein revealed the presence of shaft type of porosity. Powder microscopy revealed the presence of cork cells, stone cells, crystals and resin, fibers, needle crystal beam, thread tracheid and scalariform tracheid. Phytochemical investigation was found like alkaloids, flavones, carbohydrates, saponins, tannins and volatile oils. Results obtained in physicochemical parameters like Total ash value, acid insoluble ash and moisture content were 9.77%, 0.68% and 1.28%, respectively. The leaching degree of &lt;em&gt;P. rubra&lt;/em&gt; was higher in ethanol(75%, v/v) and methanol solutions than that in chloroform, petroleum ether, and tetrachloromethane solutions. Thin Layer Chromatography (TLC) of the extract revealed 4 spots with the Rf values 0.47, 0.46, 0.46, 0.47 with the solvent system of chloroform: methanol: water: formic acid(7:3:1:0.1). &lt;strong&gt;Conclusion:&lt;/strong&gt; The observations confirmed that&lt;em&gt; P. rubra &lt;/em&gt;has an obvious Pharmacognostic characteristics, which will be useful towards providing a reliable basis for identification, purity, quality and classification of the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">249</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Gengqiu Tang, Xiaojing Lin, Xiudi Lai, Xue Gong, Shengguo Ji&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangdong, CHINA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Archana Negi Sah</style></author><author><style face="normal" font="default" size="100%">Sweta Bawari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical Evaluation of Rhododendron arboreum Sm. from Uttarakhand</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Burans</style></keyword><keyword><style  face="normal" font="default" size="100%">Himalaya</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">SEM</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/519</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">527-532</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Rhododendron arboreum&lt;/em&gt; Sm. commonly known as Burans is an important plant of the Himalayan region. It is the national flower of Nepal and state tree of Uttarakhand. The present study pertains to the pharmacognostical evaluation of &lt;em&gt;R. arboreum&lt;/em&gt; from Uttarakhand. &lt;strong&gt;Methods:&lt;/strong&gt; Macroscopy, microscopy by free hand section cutting and with the help of scanning electron microscopy (SEM) were done along with the physicochemical analysis. Preliminary phytochemical studies and fluorescence analysis was also carried out. &lt;strong&gt;Results:&lt;/strong&gt; Results revealed that the leaves contain paracytic or amphiparacytic stomata in cluster form. The epidermal cells were long and spongy. The cells also contain some grooves and papillae throughout the surface. Preliminary phytochemical analysis showed the presence of different secondary metabolites like alkaloids carbohydrates, phenols, proteins, saponins, and tannins. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;R. arboreum&lt;/em&gt; from Uttarakhand region was investigated for its morphological and cytological characteristics with the help of scanning electron microscopy for the first time. The results provide details on the presence of several specific characters which are important for the identification of the genuine crude drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">527</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Devesh Tewari, Archana Negi Sah&lt;sup&gt;*&lt;/sup&gt;, Sweta Bawari &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Technology, Bhimtal Campus, Kumaun University, Nainital, Uttarakhand, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jeyavel Renukadevi</style></author><author><style face="normal" font="default" size="100%">Ganesan Nandhinidevi</style></author><author><style face="normal" font="default" size="100%">Muthiah Bavanilatha</style></author><author><style face="normal" font="default" size="100%">Hemanath Tharani</style></author><author><style face="normal" font="default" size="100%">Rajarajan Sathiyabama</style></author><author><style face="normal" font="default" size="100%">Subramani Vasumathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacophore Modelling of Brassicaceae Members as Potent HIF (Hypoxia Inducible Factor) Inhibitors Involved in Cancer Angiogenesis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Brassicaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">HIF</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacophore</style></keyword><keyword><style  face="normal" font="default" size="100%">Simulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/673</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">798-802</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Angiogenesis is considered as an essential pathological feature of cancer due to its interplay between cancer and other diseases. Natural products found to act as antiangiogenic agents that mediate the angiogenic switch between pro and anti angiogenic factors. Among the different targets, HIF is an important and critical factor that stands as a key mediator between angiogenesis, inflammation and cancer. In our study different phytochemicals of Brassicaceae were analysed for their drug like properties and mapped for pharmacophore development. The developed pharmacophore was virtually screened and further subjected to Lipinski and ADMET filters. The molecular interaction studies of the 10 retrieved compounds were studied by binding with HIF. Among the compounds 1stdrug like molecule HTS 0115 (C&lt;sub&gt;15&lt;/sub&gt;H&lt;sub&gt;21&lt;/sub&gt;BrN&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;) was found to have best docked score and its interaction was further validated using dynamics simulation. The compound found to share the pharmacophoric features with progoitrin a biochemical form of glucosinolate with reported anticancer and anti thyroid activities. Thus the drug like compound HTS 0115 can be further optimised as a putative HIF inhibitor in tumor angiogenesis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jeyavel Renukadevi&lt;sup&gt;*1&lt;/sup&gt;, Ganesan Nandhinidevi&lt;sup&gt;1&lt;/sup&gt;, Muthiah Bavanilatha&lt;sup&gt;2&lt;/sup&gt;, Hemanath Tharani&lt;sup&gt;1&lt;/sup&gt;, Rajarajan Sathiyabama&lt;sup&gt;1&lt;/sup&gt;, Subramani Vasumathi&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Anna University, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Sathyabama University, Chennai, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tamilarasan Tamil Kumar</style></author><author><style face="normal" font="default" size="100%">Seeni Mohamed Salique</style></author><author><style face="normal" font="default" size="100%">Mohamed Hussain Muhammad Ilyas</style></author><author><style face="normal" font="default" size="100%">Nooruddin Thajuddin</style></author><author><style face="normal" font="default" size="100%">Annamalai Panneerselvam</style></author><author><style face="normal" font="default" size="100%">Mohamed Khan Syed Ali Padusha</style></author><author><style face="normal" font="default" size="100%">Hussain Syed Jahangir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antimicrobial Studies in Leaf Extracts of Indigofera aspalathoides (Vahl.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activities</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigofera aspalathoides</style></keyword><keyword><style  face="normal" font="default" size="100%">MS</style></keyword><keyword><style  face="normal" font="default" size="100%">NMR</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1208-1215</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In traditional Indian herbal medicine, the plant &lt;em&gt;Indigofera aspalathoides&lt;/em&gt; (Vahl.) has been used to treat various human ailments. &lt;strong&gt;Methods and Results:&lt;/strong&gt; Various phytochemical compounds (Rf value) such as Tannin (1.14), Flavonoid (1.14), Saponin (0.87), Sterol (0.88) and Phenol (0.86) were found in the leaf extract. The antimicrobial effects of the phytoconstituents were examined for three bacterial and fungal species. The highest anti-bacterial and antifungal activities were found in flavonoid compound, where the maximum zone of inhibition was recorded in &lt;em&gt;Staphylococcus aureus&lt;/em&gt; 18mm compared to positive control chloramphenicol (24mm). 13mm observed in &lt;em&gt;A. flavus&lt;/em&gt; and &lt;em&gt;A. ochraceous&lt;/em&gt; where positive control streptomycin exhibits 18mm. GC-MS analysis revealed the presence of three major compounds in 8&amp;alpha; (2H)-Phenanthrenol, 7-ethenyldodecahydro-1,1,4&amp;alpha;, 7-tetramethyl-, acetate, [4&amp;alpha;s(4&amp;alpha;&amp;alpha;, 4b&amp;alpha;, 7&amp;alpha;, 8&amp;alpha;&amp;alpha;, 10&amp;alpha;&amp;alpha;)], Benzoic acid, 4-methyl- , 2-oxo-2- phenylethyl ester and Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1S-(1&amp;alpha;,2&amp;alpha;,5&amp;alpha;)] in the crude extracts. The preparative HPLC analysis proved the presence of single peak from the crude flavonoid compounds, where the absorption maximum was between 207-290nm exhibited by the UV spectrum analysis. FTIR spectrum confirmed the presence of amide group, phenol group, carboxylic acid, alkynyl, alkene and aromatic ring. NMR studies proved the presence of phenyl group, methyl group and H&lt;sub&gt;2&lt;/sub&gt;C-CH group and their molecular weight recorded as 353 through the mass spectrum analysis. &lt;strong&gt;Conclusion:&lt;/strong&gt; The identified compound considered as the vital compound to design the &amp;ldquo;green antimicrobial drugs&amp;rdquo;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1208</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tamilarasan Tamil Kumar&lt;sup&gt;1&lt;/sup&gt;, Seeni Mohamed Salique&lt;sup&gt;1&lt;/sup&gt;, Mohamed Hussain Muhammad Ilyas&lt;sup&gt;1&lt;/sup&gt;, Nooruddin Thajuddin&lt;sup&gt;2&lt;/sup&gt;, Annamalai Panneerselvam&lt;sup&gt;3&lt;/sup&gt;, Mohamed Khan Syed Ali Padusha&lt;sup&gt;4&lt;/sup&gt;, Hussain Syed Jahangir&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post Graduate and Research Department of Botany, Jamal Mohamed College (Autonomous), Tiruchirappalli-620020, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Post Graduate and Research Department of Botany and Microbiology, A. Veeriya Vandayar Memorial Sri Pushpam College (Autonomous), Poondi-613503, Thanjavur District, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Post Graduate and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Tiruchirappalli-620020, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Consolacion Y. Ragasa</style></author><author><style face="normal" font="default" size="100%">Maria Carmen S. Tan</style></author><author><style face="normal" font="default" size="100%">Ma. Ellenita De Castro</style></author><author><style face="normal" font="default" size="100%">Mariquit M. De Los Reyes</style></author><author><style face="normal" font="default" size="100%">Glenn G. Oyong</style></author><author><style face="normal" font="default" size="100%">Chien-Chang Shen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sterols from Lentinus tigrinus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cerevisterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Ergosterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Lentinus tigrinus</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyporaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Stellasterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1079-1081</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; To investigate the chemical constituents of the dichloromethane extract of the fruiting bodies of the mushroom &lt;em&gt;Lentinus tigrinus&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The chemical constituents of &lt;em&gt;L. tigrinus&lt;/em&gt; were isolated by silica gel chromatography, while the chemical structures of the isolated compounds were identified by NMR spectroscopy. &lt;strong&gt;Results:&lt;/strong&gt; The dichloromethane extract of the fruiting bodies of &lt;em&gt;L. tigrinus&lt;/em&gt; afforded cerevisterol (&lt;strong&gt;1&lt;/strong&gt;), and a mixture of stellasterol (&lt;strong&gt;2&lt;/strong&gt;) and ergosterol (&lt;strong&gt;3&lt;/strong&gt;) in about 4:5 ratio. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first report on the isolation of &lt;strong&gt;1-3&lt;/strong&gt; from the fruiting bodies of&lt;em&gt; L. tigrinus.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1079</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Consolacion Y. Ragasa&lt;sup&gt;1,2&lt;/sup&gt;*, Maria Carmen S. Tan&lt;sup&gt;1&lt;/sup&gt;, Ma. Ellenita De Castro&lt;sup&gt;3&lt;/sup&gt;, Mariquit M. De Los Reyes&lt;sup&gt;3,4&lt;/sup&gt;, Glenn G. Oyong&lt;sup&gt;5&lt;/sup&gt;, Chien-Chang Shen&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry Department, De La Salle University Science and Technology Complex Leandro V. Locsin Campus, Bi&amp;ntilde;an City, Laguna 4024, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 3&lt;/sup&gt;Biology Department, De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 4&lt;/sup&gt;Biology Department, De La Salle University Science and Technology Complex Leandro V. Locsin Campus, Bi&amp;ntilde;an City, Laguna 4024, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Molecular Science Unit Laboratory, Center for Natural Science and Environmental Research, De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 6&lt;/sup&gt;National Research Institute of Chinese Medicine, Ministry of Health and Welfare, 155-1, Li-Nong St., Sec. 2, Taipei 112, TAIWAN.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Consolacion Y. Ragasa</style></author><author><style face="normal" font="default" size="100%">Maria Carmen S. Tan</style></author><author><style face="normal" font="default" size="100%">Virgilio C. Linis</style></author><author><style face="normal" font="default" size="100%">Chien-Chang Shen</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Triterpene and a Depside from Parmotrema austrocetratum Elix and J. Johnst.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atranorin</style></keyword><keyword><style  face="normal" font="default" size="100%">Parmeliaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Parmotrema austrocetratum</style></keyword><keyword><style  face="normal" font="default" size="100%">Rimelia austrocetrata</style></keyword><keyword><style  face="normal" font="default" size="100%">Zeorin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s27-s29</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Parmotrema austrocetratum&lt;/em&gt; Elix and J. Johnst. (syn. &lt;em&gt;Rimelia austrocetrata&lt;/em&gt; Elix and J. Johnst.) which belongs to a large genus of lichenized fungi, &lt;em&gt;Parmotrema Massalongo&lt;/em&gt; under family Parmeliaceae was investigated for its chemical constituents. &lt;strong&gt;Methods:&lt;/strong&gt; The compounds were isolated by silica gel chromatography and their chemical structures were elucidated by NMR spectroscopy. Results: Chemical investigation of the dichloromethane extract of &lt;em&gt;Parmotrema austrocetratum&lt;/em&gt; Elix and J. Johnst. has led to the isolation of zeorin &lt;strong&gt;(1)&lt;/strong&gt; and atranorin &lt;strong&gt;(2).&lt;/strong&gt; &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;P. austrocetratum&lt;/em&gt; shares similar chemical characteristic with other Parmotrema species which afforded atranorin. This work highlights the first reported isolation of &lt;strong&gt;1&lt;/strong&gt; from &lt;em&gt;P. austrocetratum&lt;/em&gt; and the genus Parmotrema.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s27</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Consolacion Y. Ragasa&lt;sup&gt;1,2,*&lt;/sup&gt;, Maria Carmen S. Tan&lt;sup&gt;1&lt;/sup&gt;, Virgilio C. Linis&lt;sup&gt;3&lt;/sup&gt;, Chien-Chang Shen&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Chemistry, De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry Department, De La Salle University Science and Technology Complex Leandro V. Locsin Campus, Bi&amp;ntilde;an City, Laguna 4024, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 3&lt;/sup&gt;Department of Biology , De La Salle University, 2401 Taft Avenue, Manila 1004, PHILIPPINES.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;National Research Institute of Chinese Medicine, Ministry of Health and Welfare, 155-1, Li-Nong St., Sec. 2, Taipei, TAIWAN.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandkishor Ramdas Kotagale</style></author><author><style face="normal" font="default" size="100%">Ankit Kedia</style></author><author><style face="normal" font="default" size="100%">Rupali Gite</style></author><author><style face="normal" font="default" size="100%">Shubham Nilkanth Rahmatkar</style></author><author><style face="normal" font="default" size="100%">Dinesh Yugraj Gawande</style></author><author><style face="normal" font="default" size="100%">Milind Janraoji Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Withaferin A attenuates Alcohol Abstinence Signs in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Corticosterone</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol withdrawal</style></keyword><keyword><style  face="normal" font="default" size="100%">HPA axis</style></keyword><keyword><style  face="normal" font="default" size="100%">Withaferin A.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1190-1195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Withania somnifera&lt;/em&gt; (WS) have been reported to inhibit acquisition and expression conditioned place preference, self-administration and withdrawal anxiety of psychostimulants. In the present work, we have assessed the effect of withaferin A on somatic and affective symptoms of ethanol withdrawal syndrome in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Animals had given free access to ethanol uninterrupted for 21 days through liquid diet. Withaferin A (5, 10 and 20 mg/kg) was injected (ip) either during the development of ethanol dependence phase (days 15 &amp;ndash; 21 or 30 min before ethanol withdrawal assessment. Withdrawal signs characterized by changes in somatic signs were measured in the open field followed by evaluation of anxiety parameters, locomotion, and depressive behavior. &lt;strong&gt;Results:&lt;/strong&gt; Withaferin A treatment 30 min before 24 h postethanol withdrawal assessment did not alter the scores of somatic behavioral signs in ethanol abstinence animals. However, withaferin A (10 and 20 mg/kg, ip) from day 15-21 prevented the ethanol withdrawal-induced elevated scores of somatic behaviors, hyperlocomotion, depressive behavior, and anxiety. Withaferin A treatment did not influence the blood ethanol levels in dependent and withdrawn animals. However, withaferin A administration attenuated the elevated plasma corticosterone and ACTH levels in ethanol-withdrawn rats, suggesting withaferin A induced anti-stress effect and stabilization of HPA axis activity could have facilitated the inhibitory effect of withaferin A on ethanol withdrawal syndrome. &lt;strong&gt;Conclusion:&lt;/strong&gt; The finding supports further investigation of withaferin A and other bioactive components of WS in alcohol addiction.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1190</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nandkishor Ramdas Kotagale, Ankit Kedia, Rupali Gite, Shubham Nilkanth Rahmatkar, Dinesh Yugraj Gawande, Milind Janraoji Umekar, Brijesh Gulabrao Taksande&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Division of Neuroscience, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ea Kristine Clarisse B. Tulin</style></author><author><style face="normal" font="default" size="100%">Ma Theresa P. Loreto</style></author><author><style face="normal" font="default" size="100%">Edgardo E. Tulin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alpha-Glucosidase Inhibitory Activity and Fractionation of Bioactive Compounds from bark Extracts of Sibucao (Caesalpinia sappan L.) In the Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Fractionation</style></keyword><keyword><style  face="normal" font="default" size="100%">Type II diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.60</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">356-360</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Diabetes is a chronic disease that affects millions of people around the world. Although conventional medicine is available, it is usually accompanied by serious side effects such as gastrointestinal problem. Thus, the search for alternative medicine from natural sources is of primary importance. &lt;strong&gt;Context:&lt;/strong&gt; The study is concerned with &lt;em&gt;Caesalpinia sappan L.&lt;/em&gt; found in the vicinity of Baybay City, Leyte Philippines. Furthermore, it deals with ethanolic and aqueous extracts of the bark only. It was conducted to determine the alpha-glucosidase inhibitory activity of C. sappan to provide evidence to support its efficacy as a folkloric medicinal plant. &lt;strong&gt;Aims:&lt;/strong&gt; This work aimed to evaluate the alpha-glucosidase inhibitory activity of aqueous and ethanolic bark extracts of Sibucao (&lt;em&gt;Caesalpinia sappan L.&lt;/em&gt;) and to partially fractionate its bioactive compounds. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Extracts were prepared in increasing concentration to get IC&lt;sub&gt;50&lt;/sub&gt; values. Samples were analysed in triplicate both for extracts and fractions collected from chromatography. &lt;strong&gt;Methods and Material:&lt;/strong&gt; &lt;em&gt;Caesalpinia sappan L.&lt;/em&gt; bark samples were collected from the vicinity of Visayas State University. Plant materials were dried, weighed and stored. Aqueous and ethanolic bark extracts were prepared using water and 20% ethanol. The total phenolic content of the extracts were determined and the &amp;alpha;-glucosidase inhibitory activity of crude bark and aqueous extracts were measured using the method of Kim &lt;em&gt;et al&lt;/em&gt;., 2011. Partial fractionation of bioactive compounds was done successively using gradient elution. The &amp;alpha;-glucosidase inhibitory activity of fractions were then determined and Rf values of active compounds were measured using thin layer chromatography (TLC). &lt;strong&gt;Results:&lt;/strong&gt; Results revealed that aqueous extract (2000 ppm) and ethanolic extract (2000 ppm) show high &amp;alpha;-glucosidase inhibitory activity of 100% and 59% respectively. IC&lt;sub&gt;50&lt;/sub&gt; values of aqueous and ethanolic extract were found to be 300.52 &amp;plusmn; 1.467 ppm and 1560.81 &amp;plusmn; 2.582 ppm, respectively. TLC of fractions show 7 peaks for aqueous extract and 6 peaks for ethanolic extract in which compound with Rf value 0.70 had the highest inhibitory activity of 65%. &lt;strong&gt;Conclusions:&lt;/strong&gt; Taken together, the high &amp;alpha;-glucosidase inhibitory activity of aqueous extracts support the effectiveness of C. sappan L. bark decoctions. In addition, results from bioassay-guided fractionation can be used as an effective tool for further isolation and characterization of &amp;alpha;-glucosidase inhibitors from Caesalpinia sappan L. in the Philippines.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">356</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ea Kristine Clarisse B. Tulin, Ma Theresa P. Loreto, Edgardo E. Tulin &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Biotechnology, Visayas State University, President, Visayas State University,PHILIPPINES.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Patcharee Poolsil</style></author><author><style face="normal" font="default" size="100%">Wilawan Promprom</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-Hyperglycemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-Hyperlipidemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Houttuynia cordata Thumb</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.65</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">382-387</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; Various properties of &lt;em&gt;Houttuynia cordata&lt;/em&gt; Thumb. has been reported. However, few studies on its pharmacological effects have been documented. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80% ethanol extract of &lt;em&gt;H. cordata&lt;/em&gt; (HCE). Their antioxidant activity and acute toxicity were also conducted. &lt;strong&gt;Methods:&lt;/strong&gt; HCE at a dose of 250 mg/kg was oral given to Streptozotocin-induced diabetic rats daily for 8 weeks. DPPH assay and HCE at the doses of 1,000, 2,000 and 3,000 mg/kg were employed in antioxidant and acute toxicity studies. &lt;strong&gt;Results:&lt;/strong&gt; HCE lowered FBG in the diabetic, but not in the normal treated rats. HCE did not affect the body weight of all rats, but recovered TP, Alb, Glob, BUN, CREA, UA, TB, AST, ALT, ALP, and reduced the elevated CHO, TG and LDL in the diabetic rats. HCE possessed relatively low antioxidant activity with IC&lt;sub&gt;50&lt;/sub&gt; of 115.98&amp;plusmn; 0.82 &amp;mu;g/mL compared to Vitamin C (42.54+1.37 &amp;mu;g/ml), but did not produce any symptoms of acute toxicity. &lt;strong&gt;Conclusions:&lt;/strong&gt; The extract of &lt;em&gt;H. cordata&lt;/em&gt; may have beneficial properties and is a new agent for diabetic treatment and improve renal and hepatic functions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">382</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Patcharee Poolsil&lt;sup&gt;*&lt;/sup&gt;, Wilawan Promprom, Chusri Talubmook &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Sciences, Mahasarakham University, Maha Sarakham Province 44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity, Biochemical Components and Sub-Chronic Toxicity of Different Brown Rice Kefir Powders</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical Components</style></keyword><keyword><style  face="normal" font="default" size="100%">Brown Rice Kefir Powder</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-Chronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.66</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">388-394</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; This study aimed to investigate and compare antioxidant activity, biochemical components and subchronic toxicity of brown rice kefir powder from three different coloured rice varieties; Khao Dawk Mali 105 (KDMLKP, white), Red Hawm (RHKP, red), and Hawm Nil (HNKP, dark purple), with cow milk kefir powder (CMKP). &lt;strong&gt;Medthods:&lt;/strong&gt; Antioxidant activity performed by using ferric reducing antioxidant power (FRAP) assay and 2, 2&amp;acute;-diphenyl-1-picrylhydrazyl (DPPH) assay. Biochemical components values including gamma-aminobutyric acid and alpha-tocopherol were determined using high performance liquid chromatography, but total phenolic compounds was detemined using the Folin-Ciocalteu reagent. Sub-chronic toxicity test, KDMLKP, RHKP and HNKP at the doses of 150 mg/kg were given orally to the rats every day for 90 days. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activity showed that brown rice kefir powders were significantly (p&amp;le;0.05) higher than cow milk kefir powder. Interestingly, HNKP provided the highest FRAB value and the lowest IC&lt;sub&gt;50&lt;/sub&gt; of DPPH assay. HNKP had also the highest biochemical component values. Repeat administration of KDMLKP, RHKP and HNKP did not produce any symptoms of sub-chronic toxicity; mortality, hematological values, and blood biochemistry in the rats. Moreover, RHKP produced HDL increasing without CHO, TG and LDL changing in rats. &lt;strong&gt;Conclusions:&lt;/strong&gt; These data indicate that brown rice kefir powders show no sub-chronic toxicity and exhibit more antioxidant activity and biochemical component values than cow milk kefir powder. Surprisingly, RHKP showed HDL increasing while HNKP had the highest potent antioxidant activity and biochemical components. Thus, both rice kefir powders are safe and probably a new biochemical resource for health.&lt;/p&gt;`</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Supaporn Chunchom&lt;sup&gt;1&lt;/sup&gt; Chusri Talubmook&lt;sup&gt;1&lt;/sup&gt;, Sirirat Deeseenthum&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science, Mahasarakham University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham 44150, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Antioxidant Innovation Research Unit, Faculty of Technology, Mahasarakham, University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham 44150, THAILAND&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Soheir Mohamed El Zalabani</style></author><author><style face="normal" font="default" size="100%">Soad Hanna Tadros</style></author><author><style face="normal" font="default" size="100%">Abeer Mohamed El Sayed</style></author><author><style face="normal" font="default" size="100%">Areej Almaktouf Daboub</style></author><author><style face="normal" font="default" size="100%">Amany Amen Sleem</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile and Biological Activities of Essential oil of Aerial parts of Artemisia monosperma Del. Growing in Libya</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiinflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemisia monosperma</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil composition</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Libya.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.92</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">578-586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; From the bioactivity stand point &lt;em&gt;Artemisia monosperma&lt;/em&gt; Del. is reputed to have antispasmodic and anthelmintic properties. Various types of secondary metabolites were reported in A. &lt;em&gt;monosperma &lt;/em&gt;plants from different localities. &lt;strong&gt;Objective:&lt;/strong&gt; The current study was planned aiming to investigate the influence of stage of development on the composition, antimicrobial, antiinflammatory and antioxidant activities of the essential oil derived from the aerial parts of the Libyan plants. &lt;strong&gt;Material and Methods:&lt;/strong&gt; A. &lt;em&gt;monosperma&lt;/em&gt; volatiles were hydro-distilled from aerial parts of Libyan plants, collected at different stages of growth: before flowering (A1), and at beginning (A2) and by the end (A3) of flowering stage. Yields ranged from 0.16-0.26 ml/100g fresh material (A3, highest). GC/FID and GC/MS analyses were performed. &lt;strong&gt;Results:&lt;/strong&gt; Among 16-20 identified components (97.63-99.00% of total composition), 11 were common in all samples. A1 and A2 showed close amounts of hydrocarbons (63.56 and 66.55%), but lesser than A3 (88.36%); monoterpenoids were mainly represented by sabinene (13.15-22.85%), &amp;beta;-pinene (9.00-24.03%) and &amp;beta;-cis-ocimene (3.73-12.92%); while sesquiterpenoids appeared absent. Among oxygenated components (11.29, 31.08 and 35.44 % in A3, A2 and A1), bornyl acetate was the major monoterpenoid (8.00-31.00%, highest in A1); and the sesquiterpenoid, &amp;beta;-eudesmol (8.01%) was detected in A2 only. Moreover, A2 demonstrated significant antifungal effect against &lt;em&gt;Aspergillus fumigatus&lt;/em&gt; and &lt;em&gt;Geotricum candidum &lt;/em&gt;(MIC 0.98 and 0.24 &amp;mu;g/ml). &lt;strong&gt;Conclusion:&lt;/strong&gt; A3 exerted the highest anti-inflammatory activity as compared to the other volatiles. A1 restored the reduced blood GHS level in diabetic animals almost as efficiently as Vitamin E. The antioxidant activity of the volatiles is decreased during the flowering stage, being the highest before flowering (A1); this could be associated to the decreasing bornyl acetate content of the samples.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">578</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Soheir Mohamed El Zalabani&lt;sup&gt;1&lt;/sup&gt; , Soad Hanna Tadros&lt;sup&gt;1&lt;/sup&gt;, Abeer Mohamed El Sayed&lt;sup&gt;1*&lt;/sup&gt;, Areej Almaktouf Daboub &lt;sup&gt;2&lt;/sup&gt; and Amany Amen Sleem&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, College of pharmacy, CairoUniversity, Cairo, EGYPT. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, College of pharmacy, AL Zawia University, LIBYA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;3&lt;/sup&gt;Pharmacology Department, National Research Center, El-Dokki, Giza, EGYPT&lt;/em&gt;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bisma Malik</style></author><author><style face="normal" font="default" size="100%">Tanveer Bilal Pirzadah</style></author><author><style face="normal" font="default" size="100%">Inayatullah Tahir</style></author><author><style face="normal" font="default" size="100%">Reiaz Ul Rehman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemo-profiling, Antioxidant Potential and Ionomic Analysis of Cichorium intybus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aas</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant Activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Cichorium Intybus</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS.</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/197</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">917-928</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cichorium intybus&lt;/em&gt; commonly called as chicory or coffee weed was traditionally used for the treatment of various ailments associated with liver, kidney and heart. The aim of the present study was phytochemical screening, in-vitro evaluation of antioxidant potential, element analysis of wild and cultivated chicory and GC-MS analysis of methanolic leaf extract of wild chicory grown in Kashmir Himalaya. &lt;strong&gt;Method:&lt;/strong&gt; To achieve this goal, the qualitative and quantitative analysis was done to determine the antioxidant potential. Element analysis was done using AAS and metabolite fingerprinting was done using GC-MS to ascertain the presence of active phytoconstituents in chicory leaves. &lt;strong&gt;Results:&lt;/strong&gt; The qualitative screening of leaf extracts from wild and cultivated chicory indicates the presence of important bioactive constituents. The leaf extract of wild chicory constituted the higher amount of total phenol and flavonoid contents and also showed strong radical scavenging activities of DPPH, SOD and hydrogen peroxide radical as indicated by lower values of IC50 compared to cultivated chicory. Furthermore, both extracts of wild chicory showed the highest total antioxidant potential for the reduction of Fe3+ to Fe2+ when compared with cultivated chicory. The results from the elemental analysis shows that leaf extract of wild chicory exhibits higher concentration of elements as compared to cultivated one, thus can be used as a potential bio-fortified crop. The GC-MS analysis determines the presence of 78 different compounds in the methanolic leaf extract of wild chicory. The major phytochemical constituents were phytol (7.96%) and stigmat-5-en-3-ol (6.45%). &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of the present study suggested the therapeutic potential of chicory leaves; particularly wild chicory proves to be a potent source of natural antioxidant against free radical associated damages. Metabolite profiling study revealed important metabolites having potent pharmacological actions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">917</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bisma Malik&lt;sup&gt;1&lt;/sup&gt;, Tanveer Bilal Pirzadah&lt;sup&gt;1&lt;/sup&gt;, Inayatullah Tahir&lt;sup&gt;2&lt;/sup&gt;, Reiaz Ul Rehman&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Bioresources, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, University of Kashmir, Srinagar, Jammu and Kashmir, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Areeya Suchantabud</style></author><author><style face="normal" font="default" size="100%">Teeraporn Katisart</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chronic Toxicity of Leaf Extract from Sphagneticola trilobata (L.) Pruski</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood biochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematological values</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological feature</style></keyword><keyword><style  face="normal" font="default" size="100%">S. trilobata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.55</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">323-328</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Sphagneticola trilobata&lt;/em&gt; (L.) Pruski. is a member of the family Asteraceae and has used traditionally in the prevention and treatment of various diseases. &lt;strong&gt;Aim:&lt;/strong&gt; The research was aimed to determine chronic toxicity of 80% ethanolic leaf extract from &lt;em&gt;S.trilobata&lt;/em&gt; (STLE). Materials and Methods: STLE at the doses of 200 or 400 mg/kg b. w. was oral given to the healthy Wistar rats daily for 90 days. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Statistical analysis was carried out using F-test (One-Way ANOVA) followed by Duncan&amp;rsquo;s New Multiple Range Test. &lt;strong&gt;Results:&lt;/strong&gt; STLE did not produce any signs or symptoms of chronic toxicity. And also, the mortal rat was not observed during a period of an observation. Furthermore, STLE did not alter the body weight, relative organ (liver, pancreas, kidney and heart) weight, hemoglobin (Hb), hematocrit (Hct), red blood cell (RBC), white blood cell (WBC), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), neutrophil, lymphocyte, monocyte, platelet, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN), creatinine, blood cell characteristics, ultrastructure of RBC, and histological features of hepatic, pancreatic and renal tissues in the STLE treated rats comparing to control rats. &lt;strong&gt;Conclusions:&lt;/strong&gt; These findings indicate that the leaf extract from &lt;em&gt;S. trilobata&lt;/em&gt; exerts non chronic toxicity in rats and can be used safely as a traditional medicine or diet complement without any effect on hepatic and renal functions. &lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Areeya Suchantabud&lt;sup&gt;1*&lt;/sup&gt;, Teeraporn Katisart&lt;sup&gt;2&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Candidate, Faculty of Science, Mahasarakham University, Kantarawichai, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Science, Mahasarakham University, Kantarawichai, Maha Sarakham,44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Balachandran Karpaga Raja Sundari</style></author><author><style face="normal" font="default" size="100%">Srivani Telapolu</style></author><author><style face="normal" font="default" size="100%">Bilikere S</style></author><author><style face="normal" font="default" size="100%">Dwarakanath</style></author><author><style face="normal" font="default" size="100%">Sadras. P. Thyagarajan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic and Antioxidant Effects in Various Tissue Extracts of Plumbago zeylanica: Implications for Anticancer Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549 Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Alcoholic Root Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC Quantification</style></keyword><keyword><style  face="normal" font="default" size="100%">Plumbagin</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcriptome Analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.111/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">706-712</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Complex natural products are emerging as a potent alternate and complement in anticancer therapies due to its multiple mechanisms of action and minimal effects on nontarget cells/tissues. Some of the traditional herbal formulations contain &lt;em&gt;Plumbago zeylanica &lt;/em&gt;L, (commonly known as Chitraka or Chitramoolam) to treat various disorders for centuries in Africa and Asia. &lt;strong&gt;Methods:&lt;/strong&gt; The quantity of Plumbagin was detected in different tissues of &lt;em&gt;P. zeylanica&lt;/em&gt; through HPTLC analysis. We evaluated and compared the alcoholic tissue extracts of leaf, stem and root of &lt;em&gt;P. zeylanica&lt;/em&gt; with standard pure Plumbagin for its &lt;em&gt;in vitro&lt;/em&gt; cytotoxic effects (metabolic viability; MTT assay) in A549 Lung cancer cells and antioxidant potential (DPPH free radical scavenging and total phenol content). RNA sequencing and transcriptome analysis was performed in the most potent tissues of &lt;em&gt;P. zeylanica&lt;/em&gt; demonstrating efficient pharmacological activity. &lt;strong&gt;Results:&lt;/strong&gt; The root extract containing 1.3% of plumbagin exhibited strongest scavenging potential with 50% radical scavenging (IC&lt;sub&gt;50&amp;nbsp;&lt;/sub&gt;value of 3.99 &lt;em&gt;&amp;mu;&lt;/em&gt;g) in comparison with 35.85 &lt;em&gt;&amp;mu;&lt;/em&gt;g in stem (0.2% Plumbagin) and 18.06 &lt;em&gt;&amp;mu;&lt;/em&gt;g in leaf with 0.00007% Plumbagin. The &lt;em&gt;in vitro&lt;/em&gt; cytotoxicity in A549 cells also showed that the root extract was most potent with an IC&lt;sub&gt;50&amp;nbsp;&lt;/sub&gt;value of 164.5&amp;nbsp;&lt;em&gt;&amp;mu;&lt;/em&gt;g as compared to extracts from stem (IC&lt;sub&gt;50&lt;/sub&gt;= 379.5&amp;mu;g) and leaf (IC50= 274.9 &lt;em&gt;&amp;mu;&lt;/em&gt;g). &lt;strong&gt;Conclusion:&lt;/strong&gt; The strong antioxidant potential shown by the &lt;em&gt;P. zeylanica &lt;/em&gt;extract demonstrates its ability to protect the non-target (normal) cells against oxidative stress, while the cytotoxic effects suggest that it could inhibit the growth of cancerous cells. Further, transcriptome analysis predicted the expression of potent gene transcripts coding for quinone biosynthesis in the root tissues of &lt;em&gt;P. zeylanica.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">706</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Balachandran Karpaga Raja Sundari&lt;sup&gt;1*&lt;/sup&gt;, Srivani Telapolu&lt;sup&gt;2&lt;/sup&gt;, Bilikere S. Dwarakanath&lt;sup&gt;3&lt;/sup&gt;, Sadras. P. Thyagarajan&lt;sup&gt;4* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. DST-National Post-Doctoral Fellow, Herbal and Indian Medicine Research Laboratory, Central Research Facility, Sri Ramachandra University, Porur, Chennai-600116, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Ph.D Scholar, Herbal and Indian Medicine Research Laboratory, Central Research Facility, Sri Ramachandra University, Chennai-600116, Tamil INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Ph.D., Professor (Research), Central Research Facility, Sri Ramachandra University, Chennai-600 116, Tamil Nadu. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Ph.D., M.D., D.Sc. Professor of Eminence &amp;amp; Dean (Research), Central Research Facility, Sri Ramachandra University, Chennai-600116, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Astrid Tilaar</style></author><author><style face="normal" font="default" size="100%">Anna Ranti</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Efficacy Study of Snake Fruit (Salacca edulis Reinw Var. Bongkok) Extract as Skin Lightening Agent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Melanin index</style></keyword><keyword><style  face="normal" font="default" size="100%">Salacca edulis Reinw</style></keyword><keyword><style  face="normal" font="default" size="100%">Snake fruit extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/306</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">235-238</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The whitening skin product market has been growing significantly in Asia Pacific. Indonesia is one of those countries that mainly think that having a white color skin is simply beautiful. Therefore, it motivates Indonesian women to buy more whitening product for their beauty needs. &lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this research is to find raw material for whitening product from Indonesian plants that can be useful as skin lightening agents. This study investigated the potential of snake fruit (&lt;em&gt;Salacca edulis&lt;/em&gt; Reinw var. Bongkok) ethanolic extract as skin lightening agent. Fruits of &lt;em&gt;Salacca edulis&lt;/em&gt; Reinw contains flavonoids which have been reported to play a part in skin depigmentation. &lt;strong&gt;Methods:&lt;/strong&gt; A randomized double-blind study on 17 human volunteers showed marked skin lightening effects using cream containing 3% extract as there was a significant reduction in skin melanin index which compared favorably with the base cream (p &amp;lt;0,05). &lt;strong&gt;Results:&lt;/strong&gt; The result strongly suggested that snake fruit ethanolic extract can be used as raw material for skin lightening agents and therefore Indonesia dependency on imported raw materials could be reduced.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">235</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Astrid Tilaar&lt;sup&gt;1,2&lt;/sup&gt;, Anna Ranti&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun&amp;rsquo;im&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, Indonesia.&amp;nbsp;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Martha Tilaar Innovation Centre, Jakarta, Indonesia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ampa Konsue</style></author><author><style face="normal" font="default" size="100%">Chayan Picheansoonthon</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fasting Blood Glucose Levels and Hematological Values in Normal and Streptozotocin-Induced Diabetic Rats of Mimosa pudica L. Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose level</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematological values</style></keyword><keyword><style  face="normal" font="default" size="100%">Mimosa pudica</style></keyword><keyword><style  face="normal" font="default" size="100%">Red blood cell</style></keyword><keyword><style  face="normal" font="default" size="100%">White blood cell</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.54</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">315-322</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt;&amp;nbsp;&lt;em&gt;M. pudica&lt;/em&gt; is a common plant found in moist waste ground, lawns, open plantations and weedy thickets. &lt;strong&gt;Aims:&lt;/strong&gt; The fasting blood glucose levels (FBG) and hematological values of &lt;em&gt;M. pudica aqueous&lt;/em&gt;(MPA) and hydro-ethanolic (MPHE) extract were evaluated in normal and streptozotocin (STZ)-induced diabetic rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; MPA and MPHE 125, 250 and 500 mg/kg body weight (b.w.) were administered orally and daily to the rats for 8 weeks. The FBG were determined weekly. Red blood cells (RBC), hemoglobin (HM. pudicab), hematocrit (Hct), platelet, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cells (WBC), lymphocytes, monocytes, neutrophils and eosinophil were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; MPA and MPHE had no effect on blood glucose levels in normal rats. All doses of all extracts showed significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing FBG in diabetic rats. Especially MPA at the dose of 250 mg/kg b.w. showed more potent significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) decreasing blood glucose levels than anti-diabetic drug glibenclamide at the end of experiment. All extracts had no effect on RBC, Hb, Hct, platelet, MCH, MCHC, lymphocytes, monocytes neutrophils and eosinophils. Surprisingly, the extracts were decreased WBC and MCV in diabetic rats. In addition, all of the extracts did not produce the alteration of blood cells structure in all rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study indicated that the extracts were hypoglycemic effect and improve hematological values in diabetes which confirms the traditional use of the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ampa Konsue&lt;sup&gt;1&lt;/sup&gt;, Chayan Picheansoonthon&lt;sup&gt;2,3&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Candidate, Faculty of Medicine, Mahasarakham University, Maha Sarakham, 44000, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Alternative Medicine College Chandrakasem Rajabhat University, Chatuchak, Bangkok 10900, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 3&lt;/sup&gt;The Academy of science, The Royal Institute Sanam Suea Pa Khet Dusti Bangkok 10300, THAILAND.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Sciences, Mahasarakham University, Maha Sarakham 44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nita Triadisti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fractionation and α-glucosidase Inhibitory Activity of Fractions from Garcinia hombroniana Pierre Leaves Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Column chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fractionation</style></keyword><keyword><style  face="normal" font="default" size="100%">Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.79</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">488-492</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus become one of the biggest global health problems of the 21st century. Type 2 diabetes play role for the majority of cases of diabetes worldwide which is characterized by the increase of postprandial blood glucose level. Maintaining postprandial glucose level through inhibition of &amp;alpha;-glucosidase is one of the essential strategies in the treatment of diabetes. Inhibitory effect of &amp;alpha;-glucosidase was commonly used to identify active compounds potentially to treat diabetes. Natural resources have potency as antidiabetic that can be used in diabetes treatment. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of the study is to separate active fraction in the crude extract of &lt;em&gt;Garcinia hombroniana&lt;/em&gt; leaves to facilitate obtaining a pure biologically active compound as the &amp;alpha;-glucosidase inhibitor. &lt;strong&gt;Methods:&lt;/strong&gt; Fractionation to separate active fraction was performed using column and thin layer chromatography methods while &amp;alpha;-glucosidase inhibitory activity assay was performed i&lt;em&gt;n vitro&lt;/em&gt; using spectrophotometric methods at &amp;lambda; 400 nm. &lt;strong&gt;Results:&lt;/strong&gt; Ethyl acetate and methanol extract of &lt;em&gt;G. hombroniana&lt;/em&gt; yielded 14 and 12 fractions, respectively. Two fractions with the higher percent inhibition compared to other factions are fraction 8 from ethyl acetate extract (FEA8) and fraction 3 from methanol extract (FM3). The IC&lt;sub&gt;50&lt;/sub&gt; values of FEA8, FM3 and acarbose are 16.370 &amp;mu;g/mL, 59.042 &amp;mu;g/mL, and 39.534 &amp;mu;g/mL respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Fraction 8 from ethyl acetate extract of &lt;em&gt;G. hombroniana&lt;/em&gt; leaves (FEA8) was separated and known in this study as the most bioactive &amp;alpha;-glucosidase inhibitor agent compared with another extract, fractions, and acarbose.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">488</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nita Triadisti&lt;sup&gt;*&lt;/sup&gt;, Rani Sauriasari, Berna Elya&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Faculty of Pharmacy, University of Indonesia, 16424, Depok, INDONESIA.&lt;/em&gt;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B. Samuel Thavamani</style></author><author><style face="normal" font="default" size="100%">Vanitha Subburaj</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Studies on Basella rubra Different Extracts as Inhibitors of Key Enzymes Linked to Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basella rubra</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Postprandial hyperglycemia</style></keyword><keyword><style  face="normal" font="default" size="100%">α-Amylase inhibitory activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">107-111</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Enzyme, inhibiting carbohydrate metabolism and thereby decreasing glucose level is a class of drugs helpful in the management of type 2 Diabetes mellitus. Naturally existing &amp;alpha;-amylase and &amp;alpha;-glucosidase inhibitors from medicinally significant plants are shown to be effective in the management of postprandial hyperglycemia. In this investigation, leaf extract (BRLE), stem extract (BRSE), fruit extract (BRFRE) and flower extract (BRFLE) of &lt;em&gt;Basella rubra &lt;/em&gt;were subjected to evaluate their antioxidant potential and their possible inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase. BRLE, BRSE, BRFRE, BRFLE (at concentration 100&amp;mu;g/ml) exhibited 65.78, 56.84, 63.1, 61.03% of &amp;alpha;-amylase inhibitory activity respectively with IC&lt;sub&gt;50&lt;/sub&gt; values of 71.66, 89.69, 73.68, 80.37 &amp;mu;g/ml respectively. In the same way BRLE, BRSE, BRFRE, BRFLE (at concentration 100 &amp;mu;g/ml) exhibited 97.63, 92.79, 82.17, 92.71 % of &amp;alpha;-glucosidase inhibition with an IC&lt;sub&gt;50&lt;/sub&gt; value of 26.97, 28.53, 41.30, 38.80 &amp;mu;g/ml respectively. Among the samples, the leaf extract of &lt;em&gt;B. rubra&lt;/em&gt; registered higher content of total phenolics and flavonoids and also higher antioxidant activity in DPPH, nitric oxide and NBT radical scavenging assays. Though all the parts had shown potent inhibitory effects on &amp;alpha;-amylase and &amp;alpha;-glucosidase, the highest inhibitory potency was observed in the leaf extract of &lt;em&gt;Basella rubra&lt;/em&gt;&amp;nbsp;(p&amp;lt;0.001).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">107</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;B. Samuel Thavamani&lt;sup&gt;1&lt;/sup&gt;* and Vanitha Subburaj&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Sanjo College of Pharmaceutical Studies, Vellapara, Chithali P.O., Kuzhalmannam, Palakkad 678702, Kerala, India.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamilnadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anita Paulina Tambunan</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Raymond Rubianto Tjandrawinata</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Extraction Parameters on the Yield, Phytochemical, TLC-Densitometric Quantification of Quercetin, and LC-MS Profile, and how to Standardize Different Batches for Long Term from Ageratum conyoides L. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Lc-Ms</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Standardization.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tlc-Densitometric</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/174</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">767-774</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Ageratum conyzoides&lt;/em&gt; Linn is one of the Indonesian herbs are used as folk medicine. There are many studies to the therapeutic activity. However, the study of the influence in extraction parameters and how to standardize different batches of plant is still limited. &lt;strong&gt;Objective:&lt;/strong&gt; The present study was designed to investigate the influence of extraction parameters on the variables matter, yield, phytochemical profile, and total quercetin from &lt;em&gt;A. conyzoides L&lt;/em&gt;. leaves extract. The study also evaluates Liquid Chromatography-Mass Spectroscopy (LC-MS) and TLC fingerprint profiles of the extract to determine the proper quality of plant material of &lt;em&gt;A. conyzoides L&lt;/em&gt;. leaves. &lt;strong&gt;Methods:&lt;/strong&gt; Different temperatures (from 0&amp;deg;C to 60&amp;deg;C), solvent types (water and 70% ethanol (%v/v), and extraction time (192 h VS 2 h) were used to investigate the influence of extraction parameters. The profiles of extract were performed by TLC and LC-MS method. &lt;strong&gt;Results:&lt;/strong&gt; The extract yield was influenced by temperature, solvent types, and time extraction. Our results suggest that the digestion technique at 60&amp;deg;C with 70% ethanol for 2h was recommended for the extraction method to obtained high yield and quercetin content as bioactive compound in &lt;em&gt;A. conyzoides L&lt;/em&gt;. leaves extract. The range of quercetin content (40&amp;ndash;52 ppm) combined with TLC and LC-MS profile can be used to determine the proper quality of plant material. &lt;strong&gt;Conclusion:&lt;/strong&gt; All parameter of extraction have an affect on the yield extract and total quercetin on the final extract. Thus, there is a need an optimized method to obtain the suitable method.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">767</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Anita Paulina Tambunan&lt;sup&gt;1&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;1*&lt;/sup&gt;, Raymond Rubianto Tjandrawinata&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Dexa Laboratories of Biomolecular Sciences, Dexa Medica, Cikarang, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Rawan El-Haj</style></author><author><style face="normal" font="default" size="100%">Dania Shoumar</style></author><author><style face="normal" font="default" size="100%">Rana Alaaeddine</style></author><author><style face="normal" font="default" size="100%">Yousra Fakhro</style></author><author><style face="normal" font="default" size="100%">Natalie Tawil</style></author><author><style face="normal" font="default" size="100%">Farah Shaer</style></author><author><style face="normal" font="default" size="100%">Amani Daher</style></author><author><style face="normal" font="default" size="100%">Natalie Awada</style></author><author><style face="normal" font="default" size="100%">Ali Sabra</style></author><author><style face="normal" font="default" size="100%">Khouloud Atwi</style></author><author><style face="normal" font="default" size="100%">Malak Khaled</style></author><author><style face="normal" font="default" size="100%">Raneem Messi</style></author><author><style face="normal" font="default" size="100%">Nour Abouzaher</style></author><author><style face="normal" font="default" size="100%">Mohamed Houri</style></author><author><style face="normal" font="default" size="100%">Samer Al Jallad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Current therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathy Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.72</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">425-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. &lt;strong&gt;Methods:&lt;/strong&gt; A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. &lt;strong&gt;Results:&lt;/strong&gt; One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients&amp;rsquo; quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. &lt;strong&gt;Conclusion:&lt;/strong&gt; Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Karim Raafat&lt;sup&gt;*&lt;/sup&gt;, Rawan El-Haj, Dania Shoumar, Rana Alaaeddine, Yousra Fakhro, Natalie Tawil, Farah Shaer, Amani Daher, Natalie Awada, Ali Sabra, Khouloud Atwi, Malak Khaled, Raneem Messi, Nour Abouzaher, Mohamed Houri and Samer Al Jallad &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, LEBANON,&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Worathat Thitikornpong</style></author><author><style face="normal" font="default" size="100%">Boonsri Ongpipattanakul</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specification and Mangiferin Content of Aquilaria crassna Leaves.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacog Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aquilaria crassna leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangiferin</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC image analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC-densitometry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January-2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/481</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">293-298</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&amp;nbsp;&lt;/strong&gt;&lt;em&gt;Aquilaria&amp;nbsp;crassna&lt;/em&gt;&amp;nbsp;Pierre ex Lecomte (Thymelaeaceae) has been used as a medicinal plant in many aspects. Previous research has revealed that &lt;em&gt;A. crassna&lt;/em&gt; leaves contain mangiferin as an active compound. Although the active component has been investigated, the pharmacognostic specification and quantification of mangiferin from &lt;em&gt;A. crassna&lt;/em&gt; leaves have never been established. &lt;strong&gt;Objective:&lt;/strong&gt; The current study aimed to conduct and develop a pharmacognostic standard according to WHO guidance as well as the validated method for quantifying mangiferin content. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Dried &lt;em&gt;A. crassna&lt;/em&gt; leaves from 15 separated locations throughout Thailand were investigated for pharmacognostic specification. Their mangiferin contents were quantitatively analysed by TLC densitometry with win CATS software. &lt;strong&gt;Results:&lt;/strong&gt; Macroscopic-, microscopic- characteristics and TLC fingerprinting combined with physicochemical parameters were reported in this study. The loss on drying, moisture content, and total ash content as well as acid-insoluble ash content were determined to be 8.62 &amp;plusmn; 0.13, 8.16 &amp;plusmn; 0.14, 6.82 &amp;plusmn; 0.09 and 1.49 &amp;plusmn; 0.03%, respectively. Ethanol- and waterextractive values were found to be 9.05 &amp;plusmn; 0.39 and 16.94 &amp;plusmn; 0.22 %, respectively. In addition, the validation method for quantifying the mangiferin content was developed. The contents of mangiferin in A.&lt;em&gt; crassna&lt;/em&gt; leaf extract determined by TLC-densitometry and TLC-image analysis were found to be 1.2992 &amp;plusmn; 0.5980 and 1.3036 &amp;plusmn; 0.5874 % by dried weight, respectively. The results between these two analytical methods were shown to have an insignificant difference. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study provides the necessary information for authentication and standardisation of &lt;em&gt;A. crassna &lt;/em&gt;leaves.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">293</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Worathat Thitikornpong&lt;sup&gt;1&lt;/sup&gt;, Boonsri Ongpipattanakul&lt;sup&gt;2&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt;, Nijsiri Ruangrungsi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1,3*&lt;/strong&gt; &lt;br /&gt;&lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Public Health Sciences, Chulalongkorn University, Bangkok 10330, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;CU Drug and Health Products Innovation Promotion Center, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Rangsit University, Patumthani 12000, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Harsha L</style></author><author><style face="normal" font="default" size="100%">Lakshmi Thangavelu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Screening of Ethanolic Extracts of Medicinal Herbal Drugs Against Oral Microbes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti cariogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Dental caries</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products Pathogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Oral bacteria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/300</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">201-203</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The aim of the present study is to screen the ethanolic extracts of medicinal herbal drugs against oral microbes. &lt;strong&gt;Objective:&lt;/strong&gt; In this study, 3 medicinal herbs were evaluated for antimicrobial activity against five common oral bacteria as a screen for potential candidates for the development of natural antibiotics. &lt;strong&gt;Methods:&lt;/strong&gt; Ethanolic extracts of medicinal herbs were tested for activity against Enterococcus faecalis, Lactobacillus acidophilus, Streptococcus mutans, and Streptococcus sanguis grown in brain heart infusion (BHI) broth. A broth microdilutionassay was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). A disk diffusion assay was performed by inoculating bacterial cultures on BHI agar plates with paper disks soaked in each of the medicinal herb extracts. &lt;strong&gt;Results:&lt;/strong&gt; The ethanolic extracts of many of the 3 medicinal herbs showed antimicrobial activity against the five types of pathogenic oral bacteria. The extracts of Caralluma fimbriata, Hemidesmus indicus, and Grape seed effectively inhibited the growth of oral bacteria and showed distinct bactericidal activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggest that alternative medicines with proven antimicrobial effects, such as Caralluma fimbriata, Hemidesmus indicus, and Grape seed may be useful for the treatment of dental diseases.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">201</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Harsha L&lt;sup&gt;1&lt;/sup&gt; , Lakshmi Thangavelu&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bachelor of Dental College and Hospitals , Saveetha Dental College and Hospitals, Chennai, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Chennai, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Napapach Chaimum-aom</style></author><author><style face="normal" font="default" size="100%">Sanong Chomko</style></author><author><style face="normal" font="default" size="100%">Chusri Talubmook</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toxicology and Oral glucose Tolerance Test (OGTT) of Thai Medicinal Plant Used for Diabetes controls, Phyllanthus acidus L. (EUPHORBIACEAE)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus acidus</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">58-61</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present study aimed to investigate toxicity and oral glucose tolerance test (OGTT) of &lt;em&gt;Phyllanthus acidus&lt;/em&gt; leaf extract (PAE) on Wistar rat. &lt;strong&gt;Methods: &lt;/strong&gt;PAE was prepared and administered orally to experimental animals used. The extract was tested for toxicity in rats at a dose of 0, 1,000, 1,500 and 2,000 mg/kg body weight p.o once daily for 14 days. The hypoglycemic effects of PAE on normal rats and orally glucose-induced hyperglycemic rats were compared with distilled water and glibenclamide. A single dose (250 mg/kg body weight) of PAE was administered and blood glucose level was obtained by pricking the tail vain using glucometer at time -30, 0, 30, 60, 120 and 240 minutes. &lt;strong&gt;Results:&lt;/strong&gt; All doses of the extract did not exert any sign or symptom of toxicity and the dead rat was not found. The body weight, white blood cell (WBC), mean corpuscular volume (MCV), platelet (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), blood chemistry, blood urea nitrogen (BUN), creatinine, alkaling phosphatase (ALP) and organ weight of liver were not significantly different between control and treated rats. However, red blood cell (RBC), hematocrit (HCT), lymphocyte (LYM), and hemoglobin (Hb) at a dose 1,500 mg./kg body weight were significantly lower than those in the control group. The blood glucose levels of PAE treated groups were not different with control and Glybenclamide treated. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of the present study can be concluded that the PAE are practically non-toxic at a lower dose.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Napapach Chaimum-aom&lt;sup&gt;1*&lt;/sup&gt;, Sanong Chomko&lt;sup&gt;2&lt;/sup&gt;, Chusri Talubmook&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Candidate, Faculty of Sciences, Kantarawichai, MahaSarakham 44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Science, Kantarawichai, MahaSarakham 44150, Thailand.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Yakoob</style></author><author><style face="normal" font="default" size="100%">Nargis Begum Tajuddin</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas Mohammed Hussain</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Archunan Govindaraju</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hypoglycemic Activities of Clausena anisata (Willd.) Hook F. Ex Benth. Root Mediated Synthesized Silver Nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">C. anisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose and Silver nitrate</style></keyword><keyword><style  face="normal" font="default" size="100%">Silvernanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">579-586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The present study was carried out to examine the hypoglycemic effect of Silver Nanoparticles (SNPs) using ethanolic root extract of &lt;em&gt;Clausena anisata&lt;/em&gt; (Willd.) Hook. f. ex Benth. A cost effective and eco friendly technique for green synthesis of SNPs from 1mM AgNO&lt;sub&gt;3&lt;/sub&gt; solution through the root extract was carried out. The biosynthesized SNPs were characterized using UV spectrophotometry, Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction analysis (XRD), Energy Dispersive Spectroscopy (EDS) and Fourier transform infra-red (FTIR) spectrometry. DPPH assay was done to determine the antioxidant activity and for &lt;em&gt;in vitro&lt;/em&gt; hypoglycemic activity glucose uptake by yeast cells, alpha amylase inhibition assay, adsorption capacity and glucose diffusion assay was performed. The SNPs of ethanolic root extract were found to be spherical in shape and up to 32.75 nm average in size. They showed alpha amylase inhibitory activity of 83.60% at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The glucose uptake by yeast cells was found to increase with an increase in concentration. The maximum glucose uptake was found to be 69.51% at 10mM concentration. The molar concentration of glucose was directly proportional to the glucose binding capacity of extracts.The rate of glucose diffusion across the membrane was found to increase from 30 to 180 minutes. The DPPH scavenging activity was found to be potent (74.07%) at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The hypoglycemic effect exhibited by the SNPs was revealed by simple in vitro model of yeast cells, mediated by glucose adsorption, increasing glucose diffusion and glucose transport across the cell membrane.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">579</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Yakoob&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum Tajuddin&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas Mohammed Hussain&lt;sup&gt;2&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Ishtiaq Qadri&lt;sup&gt;3&lt;/sup&gt;* and Archunan Govindaraju&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department Of Biotechnology, Jamal Mohamed College (Autonomous), Trichy- 20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department Of Botany, Jamal Mohamed College (Autonomous), Trichy- 20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;King Fahad Medical Research Centre, King Abdul Aziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Center For Pheromone Technology, Department Of Animal Science, Bharathidasan University Tiruchirappalli-620 024, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author><author><style face="normal" font="default" size="100%">Benjamart Cushnie</style></author><author><style face="normal" font="default" size="100%">Ladachart Taepongsorat</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Constituents and in vitro anticancer activity of  Tiliacora triandra leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">In vitro anticancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxoanolobine</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Tiliacora triandra</style></keyword><keyword><style  face="normal" font="default" size="100%">Yanang.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">1-3</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: &lt;em&gt;&amp;nbsp;Tiliacora triandra&lt;/em&gt; (F. &lt;em&gt;Menispermaceae&lt;/em&gt;) is edible and is also known for medicinal values. The leaves are a popular flavoring in Southeast Asia, especially in the northeast of Thailand.&amp;nbsp; The objectives of this study were to determine the major constituents of the leaves of &lt;em&gt;T. triandra&lt;/em&gt;, and assess their anticancer activities against human cancer cell lines. &lt;strong&gt;Methods&lt;/strong&gt;: The leaves were extracted by a soxhlet apparatus with petroleum ether, dichloromethane, ethyl acetate and water. Major constituents were then purified and identified using chromatographic procedures and various spectroscopic techniques.&amp;nbsp; &lt;em&gt;In vitro&lt;/em&gt; anticancer activity tests of &lt;em&gt;T. triandra&lt;/em&gt; extracts were performed by resazurinmicroplate assay (REMA), and tested with 3 cell lines: oral cavity cancer (KB), lung cancer (NCI-H187) and breast cancer (MCF-7) cell lines. &lt;strong&gt;Results&lt;/strong&gt;: The result indicated that the main compound of &lt;em&gt;T. triandra&lt;/em&gt; leaves was oxoanolobine. The methanol extract showed the highest cytotoxic activity against lung cancer (NCI-H187) cell line whereas the water extract exhibited the highest activity against oral cavity cancer (KB) cell line. The IC&lt;sub&gt;50&lt;/sub&gt; of oxoanolobine against the NCI-H187 cell line was 27.60 &amp;plusmn; 4.30 &amp;micro;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp; &lt;em&gt;T. triandra&lt;/em&gt; leaves contain oxoanolobine as the major constituent and have the potential of anticancer activity but are required to be investigated further.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Surapong Rattana&lt;sup&gt;1&lt;/sup&gt;, Benjamart Cushnie&lt;sup&gt;2&lt;/sup&gt;, Ladachart Taepongsorat&lt;sup&gt;3&lt;/sup&gt; and Methin Phadungkit&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, Mahasarakham University, Kantarawichai, Maha Sarakham-44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2,4&lt;/sup&gt;Faculty of Pharmacy, Mahasarakham University, Kantarawichai, Maha Sarakham-44150, Thailand.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Mahasarakham University, Meuang, MahaSarakham-44000, Thailand.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muniyandi Anbukkarasi</style></author><author><style face="normal" font="default" size="100%">Philip A Thomas</style></author><author><style face="normal" font="default" size="100%">Mahalingam Sundararajan</style></author><author><style face="normal" font="default" size="100%">Pitchairaj Geraldine</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gas Chromatography - Mass Spectrometry Analysis and In vitro Antioxidant Activity of the Ethanolic Extract of the Leaves of Tabernaemontana divaricata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Metal chelating activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Reducing power</style></keyword><keyword><style  face="normal" font="default" size="100%">Tabernaemontana divaricata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">451-458</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To identify phytoconstituents present in an ethanolic extract of the leaves of &lt;em&gt;Tabernaemontana divaricata &lt;/em&gt;and to evaluate its in-vitro antioxidant potential. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was subjected to gas chromatography- mass spectrometry analysis to identify phytoconstituents, and screened for hydroxyl, superoxide and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power and metal-chelating activity as a measure of potential antioxidant activity. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS analysis of the extract revealed the presence of 96 phytoconstituents, of which 17 are reported to be bioactive and 11 of these to possess antioxidant potential. When tested&lt;em&gt; in-vitro&lt;/em&gt;, the extract exhibited the most potent radical-scavenging activity at a maximum concentration of 10 mg/ml, scavenging effects of 64%, 67% and 69% and corresponding half maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values of 6.7 mg/ml, 6.8 mg/ml and 6.2 mg/ml on hydroxyl, superoxide and DPPH radicals, respectively. Ascorbic acid used as a standard (10 mg/ml) showed scavenging effects of 73%, 73% and 75% and corresponding IC&lt;sub&gt;50 &lt;/sub&gt;values of 5.3 mg/ml, 5.8 mg/ml and 5.2 mg/ml, respectively, on hydroxyl, superoxide and DPPH radicals. At 10 mg/ml, the extract and an ethylenediaminetetraacetic acid standard exhibited 68% and 78%, respectively, chelation of ferrous ions; at the same concentration, the reducing power of the extract and that of a butylated hydroxytoluene standard was found to be 3.855 and 4.308, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; These observations strongly suggest that the ethanolic extract of &lt;em&gt;T. divaricata&lt;/em&gt; leaves has potent&lt;em&gt; in-vitro&lt;/em&gt; antioxidant activity and thereby could act as a possible therapeutic agent for oxidative stressinduced pathological states.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">451</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muniyandi Anbukkarasi&lt;sup&gt;1&lt;/sup&gt;, Philip A Thomas&lt;sup&gt;2&lt;/sup&gt;, Mahalingam Sundararajan&lt;sup&gt;1&lt;/sup&gt;, Pitchairaj Geraldine&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli- 620 024, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ocular Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli- 620 001, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Yakoob</style></author><author><style face="normal" font="default" size="100%">Nargis Begum Tajuddin</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas Mohammed Hussain</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gc-Ms Analysis of Ethanolic Stem Extract of Clausena anisata (Willd.) Hook F Ex Benth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">C. anisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">maceration and phytoconstituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">576-578</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; In the present study, the bioactive components present in the ethanol stem extract of &lt;em&gt;Clausena anisata&lt;/em&gt; was analyzed by using Gas Chromatography Mass Spectrometry analysis technique (GC-MS). &lt;em&gt;Clausena anisata&lt;/em&gt;, a medicinal plant belonging to the family &lt;em&gt;Rutaceae&lt;/em&gt;, is represented by 20 species available in India and used traditionally for the treatment of several ailments but there is a requirement to identify its phytoconstituents, its target, mode of action and treatment using plant products either alone or in combination with synthetic drugs. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;Clausena anisata&lt;/em&gt; stem was procured from Manamettupatti, a village of Pudukottai District, Tamil Nadu. The shade dried stem was powdered and extracted using ethanol by maceration method. One microlitre of the extract was subjected to GC-MS analysis to detect the presence of bioactive compounds present in the stem of &lt;em&gt;C. anisata&lt;/em&gt;.&lt;strong&gt; Results:&lt;/strong&gt;The results showed that the ethanol stem extract of &lt;em&gt;C. anisata&lt;/em&gt; contained nine bioactive compounds, of which the major one is n-hexadecanoic acid (78.54%), followed by 8-octadecenoic acid, methyl ester, [E]- (6.638%). The total number of compounds obtained was compared with National Institutes of Standard and Technology (NIST) library that contains more than 62,000 known compounds based on retention time and molecular mass. &lt;strong&gt;Conclusion: &lt;/strong&gt;In this study, nearly nine compounds have been identified from the ethanolic stem extract of &lt;em&gt;C. anisata &lt;/em&gt;using GC-MS analysis which was mainly composed of fatty acids and sterols. The GC-MS analysis is used to understand the nature of active principles present in this plant revealed that the plant can be used as a potential source of new useful drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">576</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Yakoob&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum Tajuddin&lt;sup&gt;1&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas Mohammed Hussain&lt;sup&gt;1&lt;/sup&gt;, Ishtiaq Qadri&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Jamal Mohamed College (Autonomous), Trichy, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Kau University, Jeddah, K.S.A.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Y</style></author><author><style face="normal" font="default" size="100%">Nargis Begum T</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas MH</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Archunan Govindaraju</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green synthesis, Antioxidant Potential and Hypoglycemic Effect of Silver Nanoparticles using Ethanolic Leaf Extract of Clausena anisata (Willd.) Hook. F. Ex Benth. of Rutaceae</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">565-575</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The current study was conducted to examine the hypoglycemic effect of Silver Nano particles (SNPs) using ethanolic leaf extract of &lt;em&gt;Clausena anisata &lt;/em&gt;(Willd.) &lt;em&gt;Hook f. &lt;/em&gt;ex Benth. A cost effective and eco-friendly technique for the green synthesis of SNPs from 1mM AgNO&lt;sub&gt;3&lt;/sub&gt; solution through the leaf extract was carried out. The biosynthesized SNPs were characterized using UV spectro photometry, Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction analysis (XRD), Energy Dispersive Spectroscopy (EDS) and Fourier transform infra-red (FTIR) spectrometry. DPPH assay was done to determine the antioxidant activity and for &lt;em&gt;in vitro&lt;/em&gt; hypoglycemic activity glucose uptake by yeast cells, alpha-amylase inhibition assay, adsorption capacity and glucose diffusion assay was carried out. The SNPs of ethanol leaf extract were found to be spherical in shape and up to 60.67 nm average in size. They showed alpha-amylase inhibitory activity of 80.32% at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml and IC&lt;sub&gt;50&lt;/sub&gt; 100 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The glucose uptake by yeast cells was found to increase with an increase in concentration. The maximum glucose uptake was found to be 68.29% at 10mM concentration. The molar concentration of glucose was directly proportional to the glucose binding capacity of extracts. The rate of glucose diffusion across the membrane was found to increase from 30 to 180 minutes. The DPPH scavenging activity was found to be potent (71.60%) at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The hypoglycemic effect exhibited by the SNPs was revealed by simple &lt;em&gt;in vitro &lt;/em&gt;model of yeast cells, mediated by glucose absorption, increasing glucose diffusion and glucose transport across the cell membrane.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">565</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Y&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum T&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas MH&lt;sup&gt;2&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Archunan Govindaraju&lt;sup&gt;3&amp;nbsp;&lt;/sup&gt;and Ishtiaq Qadri&lt;sup&gt;4&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG &amp;amp; Research Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli,INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;PG &amp;amp; Research Department of Botany, Jamal Mohamed College, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Science, Bharathidasan University Tiruchirappalli-620 024, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;King Fahd Medical Research Centre, Jeddah, K.S.A.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Debasish Pradhan</style></author><author><style face="normal" font="default" size="100%">Gitanjali Tripathy</style></author><author><style face="normal" font="default" size="100%">Rakesh Kumar Pradhan</style></author><author><style face="normal" font="default" size="100%">Shaktiprasad Pradhan</style></author><author><style face="normal" font="default" size="100%">Soumyashree Rupambika Moharana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition of MDR1 in mammary cell carcinoma reverses Multidrug Resistance by SOCS1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MDR1gene</style></keyword><keyword><style  face="normal" font="default" size="100%">Multidrug resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">RNA interference.</style></keyword><keyword><style  face="normal" font="default" size="100%">SOCS1 gene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">103-112</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Suppressors of cytokine signalling (SOCS1), a newly indentified antiapoptotic molecule is a downstream effector of the receptor tyrosine kinase-Ras signalling pathway. Current study has uncovered that SOCS1 may have wide and imperative capacities, particularly because of its close correlation with malignant tumors. &lt;strong&gt;Methods:&lt;/strong&gt; To investigate the impact of SOCS1 on MDR, we analyzed the expression of P-gp and SOCS1 by immunohistochemistry and found there was positive correlation between them. At that point we effectively interfered with RNA translation by the contamination of siRNA of SOCS1 into MCF7/ ADM breast cancer cell lines through a lentivirus, and the expression of the target gene was significantly inhibited. &lt;strong&gt;Results:&lt;/strong&gt; After RNAi the drug resistance was reduced altogether and the expression of MDR1 mRNA and P-gp in MCF7/ADM cell lines demonstrated a significant decrease. Likewise the expression of P53 protein increased in a statistically significant manner (p&amp;le;0.01) after RNAi exposure. Moreover, flow cytometry analysis uncovers that cell cycle and anti-apoptotic enhancing capacity of cells changed after RNAi treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; These outcomes proposed SOCS1 may take part in breast cancer MDR by managing MDR1 and P53 expression, changing cell cycle and enhancing the anti-apoptotic ability of cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">103</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Debasish Pradhan*, &lt;/strong&gt;&lt;strong&gt;Gitanjali Tripathy,&lt;/strong&gt; &lt;strong&gt;Rakesh Kumar Pradhan, Shaktiprasad Pradhan, Soumyashree Rupambika Moharana&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar, Odisha, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shantha Thirumalai Ramaseshan</style></author><author><style face="normal" font="default" size="100%">Patchaimal Pitchaiah</style></author><author><style face="normal" font="default" size="100%">Vandana Bharti</style></author><author><style face="normal" font="default" size="100%">Kishore Kumar Ramakrishna</style></author><author><style face="normal" font="default" size="100%">Venkateshwarlu Gaddam</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Chinmay Rath</style></author><author><style face="normal" font="default" size="100%">Anupam Mangal</style></author><author><style face="normal" font="default" size="100%">Padhi Madan Mohan</style></author><author><style face="normal" font="default" size="100%">Dhiman Kartar Singh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical, Phytochemical and Nutritional Evaluation of Glinus oppositifolius (L.) Aug. DC</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Histochemical studies.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Powder microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">Thin layer Chromatography.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">31-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The primary aim of the study was to establish the pharmacognostic standards along with nutritional values on the important medicinal herb &lt;em&gt;Glinus oppositifolius &lt;/em&gt;(L.) Aug&lt;em&gt;. &lt;/em&gt;DC., commonly known as Parpata in South India. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Pharmacognostical, physicochemical, nutritional evaluation along with the TLC profiling and preliminary phytochemical screening was carried out. &lt;strong&gt;Results: &lt;/strong&gt;Histological study of different parts of the plant revealed the presence of different cellular structures viz. stem showed the presence of multi cellular to unicellular trichomes, collateral vascular bundles, starch grains etc. Mesophyll of the leaves was embedded with starch grains with clustered calcium oxalate and prism shaped crystals. Anomocytic stomata were present on both the epidermis of the leaf. Powder microscopy exhibited multi cellular trichomes, clustered calcium oxalate, fibres etc. Physicochemical and histochemical studies revealed the presence of various secondary metabolites and different minerals within the acceptable limits. Thin layer chromatographic profiling showed different spots suggesting the presence of specific phytoconstituents in different extracts. The plant also revealed good nutritional value with calorific value of about 245 kcal/100g; Vitamin C 112 mg/100 g and higher amount of calcium etc. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results are beneficial to establish the quality control parameters of the plant species and may be served as future reference for the identification and authentication of the genuine crude drug and also provide sufficient data to recognize the use of the plant as dietary suppliment.&amp;nbsp;&amp;nbsp; &amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">31</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shantha Thirumalai Ramaseshan&lt;sup&gt;1*&lt;/sup&gt;, Patchaimal Pitchaiah&lt;sup&gt;1&lt;/sup&gt;, Prathapa Reddy Maramreddy&lt;sup&gt;1&lt;/sup&gt;, Vandana Bharti&lt;sup&gt;1&lt;/sup&gt;, Kishore Kumar Ramakrishna&lt;sup&gt;1&lt;/sup&gt;, Venkateshwarlu Gaddam&lt;sup&gt;1&lt;/sup&gt;, Devesh Tewari&lt;sup&gt;2&lt;/sup&gt;, Chinmay Rath&lt;sup&gt;2&lt;/sup&gt;, Anupam Mangal&lt;sup&gt;2&lt;/sup&gt;, Padhi Madan Mohan&lt;sup&gt;2&lt;/sup&gt; and Dhiman Kartar Singh&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&amp;nbsp;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;National Ayurveda Dietetics Research Institute, Central Council for Research in Ayurvedic Sciences, Ashoka pillar, Jayanagar, Bangalore-560011, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Government of India, Janakpuri, New Delhi-110058, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shantha Thirumalai Ramasheshan</style></author><author><style face="normal" font="default" size="100%">Patchaimal Pitchaiah</style></author><author><style face="normal" font="default" size="100%">Prathapa Reddy Maramreddy</style></author><author><style face="normal" font="default" size="100%">Vandana Bharti</style></author><author><style face="normal" font="default" size="100%">Kishore Kumar Ramakrishana</style></author><author><style face="normal" font="default" size="100%">Venkateshwarlu Gaddam</style></author><author><style face="normal" font="default" size="100%">Devesh Tewari</style></author><author><style face="normal" font="default" size="100%">Anupam Kumar Mangal</style></author><author><style face="normal" font="default" size="100%">Madan Mohan Padhi</style></author><author><style face="normal" font="default" size="100%">Kartar Singh Dhiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical Standardization of Goraksha pods: an important Nutritive and antidiabetic Plant</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cluster beans</style></keyword><keyword><style  face="normal" font="default" size="100%">Goraksha</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pods. Histochemical studies.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">424-429</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Goraksha or cluster beans are an annual legume found throughout India. It is also extensively cultivated for its pods used as vegetable for its high nutritive value, antidiabetic properties and for the source of guargum.&lt;strong&gt; Methods: &lt;/strong&gt;Macroscopy, microscopy, powder microscopy, histochemical studies and preliminary phytochemical studies on the pods of Goraksha has been carried out highlighting its importance along with important diagnostic characters, which will help in the identification of pods both in fresh form as well as in dry form. &lt;strong&gt;Results:&lt;/strong&gt; Study revealed presence of distantly arranged elongated uniseriate warty trichomes in the outer most layer of epidermis, presence of stone cells, simple starch grains and very small calcium oxalate crystals in the hypodermal region. Presence of unevenly thickened row of palisade layer of macro sclereids in the outer most layer of cotyledon region. Phytochemical studies revealed the presence of alkaloids carbohydrates, phenols, proteins, saponins, starch, steroids, and tannins. &lt;strong&gt;Conclusion: &lt;/strong&gt;The pharmacognostical standardization revealed the presence of various specific characters which are important for the identification of the genuine pods of&lt;em&gt; Cyamopsis tetragonoloba&lt;/em&gt; (L.) Taub.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">424</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shantha Thirumalai Ramasheshan&lt;sup&gt;1*&lt;/sup&gt;, Patchaimal Pitchaiah&lt;sup&gt;1&lt;/sup&gt;, Prathapa Reddy Maramreddy&lt;sup&gt;1&lt;/sup&gt;, Vandana Bharti&lt;sup&gt;1&lt;/sup&gt;, Kishore Kumar Ramakrishana&lt;sup&gt;1&lt;/sup&gt;, Venkateshwarlu Gaddam, Devesh Tewari&lt;sup&gt;2&lt;/sup&gt;, Anupam Kumar Mangal&lt;sup&gt;2&lt;/sup&gt;, Madan Mohan Padhi&lt;sup&gt;2&lt;/sup&gt;, Kartar Singh Dhiman&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Regional Ayurveda Research Institute for Metabolic Disorders (CCRAS, Min. of AYUSH) Ashoka pillar, Jayanagar, Bengaluru-560011, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Central Council for Research in Ayurvedic Sciences, Ministry of AYUSH, Govt. of India, Janakpuri, New Delhi-110058, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cristiane Cardoso Correia Teixeira</style></author><author><style face="normal" font="default" size="100%">Tatiana Pereira de Freitas Cabral</style></author><author><style face="normal" font="default" size="100%">João Paulo Barreto de Sousa</style></author><author><style face="normal" font="default" size="100%">Simone de Pádua Teixeira</style></author><author><style face="normal" font="default" size="100%">Jairo Kenupp Bastos</style></author><author><style face="normal" font="default" size="100%">Luis Alexandre Pedro de Freitas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Quality Assurance For Peumus Boldus M Products By Botanic Profiling, Extraction Optimization, HPLC Quantification And Antioxidant Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Boldine</style></keyword><keyword><style  face="normal" font="default" size="100%">Peumus boldus</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">264-272</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The boldo leaf has several traditional folk medicinal uses, such as for gallbladder, hepatic problems, digestive disorders, rheumatism and others. In the work reported herein, botanic profiling, extraction optimization by Soxhlet, quantification of boldine by an easy/simple to run HPLC method and antioxidant assay are proposed for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules.&lt;strong&gt; Materials and Methods; &lt;/strong&gt;In this present work we are studying a systematic approach in the quality assurance study of quality assurance for &lt;em&gt;Peumus boldus&lt;/em&gt; M products by the ascertainment of pharmacobotanic parameters for boldo identification, investigation of the extraction parameters by Soxhlet method, development and validation of an easy/simple to run HPLC method to quantify boldine in the raw drug, extracts, commercial tablets, capsules and coated tablets, and antioxidant assay.&lt;strong&gt; Results:&lt;/strong&gt; The plant material was submitted to a pharmacognostic evaluation through morpho-anatomical diagnosis, showing that starlike trichomes can be used for boldo authentication. The HPLC validated analytical method is reliable, accurate and precise for boldine quantification. Furthermore, the Soxhlet extraction conditions were optimized.&lt;strong&gt; Conclusion:&lt;/strong&gt; The methods proposed in this paper can be used for the quality assurance of boldo dried leaves, standardized extracts, dried extracts, tablets and capsules.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">264</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Cristiane Cardoso Correia Teixeira, Tatiana Pereira de Freitas Cabral, Jo&amp;atilde;o Paulo Barreto de Sousa, Simone de P&amp;aacute;dua Teixeira, Jairo Kenupp Bastos, Luis Alexandre Pedro de Freitas* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Departamento de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas, N&amp;uacute;cleo de Pesquisas em Produtos Naturais e Sint&amp;eacute;ticos, Faculdade de Ci&amp;ecirc;ncias Farmac&amp;ecirc;uticas de Ribeir&amp;atilde;o Preto, Universidade de S&amp;atilde;o Paulo, Via do Caf&amp;eacute;, S/N, 14040-903, Ribeir&amp;atilde;o Preto, SP, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iman Nasrollahi</style></author><author><style face="normal" font="default" size="100%">Ebrahim Talebi</style></author><author><style face="normal" font="default" size="100%">Zahra Nemati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study on Silybum marianum Seed through Fatty Acids Comparison, Peroxide Tests, Refractive Index and Oil Percentage</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Milk Thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Peroxide</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">595-597</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;In this study, &lt;em&gt;milk thistle&lt;/em&gt; seeds were collected from four regions of Iran (Ahvaz, Lorestan, Kazeroon and Zarghan). The oil extracted from seeds of plant using n-hexane solvent extraction soxhlet. The extracted oil was analyzed by gas chromatography and fatty acids were identified in all four samples. In all four samples, the oil refractive index of &lt;em&gt;Milk thistle&lt;/em&gt; oil fatty acids vis. Linoleic acid, Oleic acid, Palmitic acid was evaluated. The Peroxide test and determination of oil percentage was performed in &lt;em&gt;Milk thistle&lt;/em&gt; seed oil.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">595</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Iman Nasrollahi&lt;sup&gt;1&lt;/sup&gt;*, Ebrahim Talebi&lt;sup&gt;1&lt;/sup&gt;, Zahra Nemati&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Young Researchers and Elite Club, Darab Branch, Islamic Azad University, Darab, Fars, Iran&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Shiraz branch Islamic Azad university , Shiraz , Fars, IRAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nahid Mahmoud Hassan El-Ameen</style></author><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Asaad Khalid</style></author><author><style face="normal" font="default" size="100%">Fatima Elfatih</style></author><author><style face="normal" font="default" size="100%">Mona Awad Kamel</style></author><author><style face="normal" font="default" size="100%">Bassem Yousif Sheikh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-diabetic Properties of Thymoquinone is unassociated with Glycogen Phosphorylase Inhibition</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycogen phosphorylase inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Thymoquinone.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">406-410</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Nigella sativa&lt;/em&gt; L. (Black seed), is commonly used by traditional healers as a remedy for more than four thousand years. The antidiabetic property of &lt;em&gt;N. sativa&lt;/em&gt; seeds oil is attributable to the presence of Thymoquinone (TQ). On the other hand many studies have been designed to investigate the possible effects of the TQ in Streptozotocin (STZ) and nicotinamide (NA)-induced diabetes in rats. &lt;strong&gt;Aim of the study: &lt;/strong&gt;The aim of this study was to elucidate the mechanisms underlying the glucose lowering effects of thymoquinone. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; and &lt;em&gt;in silico&lt;/em&gt; using glycogen phosphorylase (GPa) enzyme assay and docking tools were used. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of TQ for 60 days, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. GPa activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phosphate. TQ at a concentration of 0.05 Mm inhibits GPa activity by only 14.9%. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results show that TQ at 60 mg/kg b.w is associated with potential antihyperglycemic effects. Furthermore, anti-diabetic properties of TQ are unassociated with glycogen phosphorylase inhibition.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">406</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nahid Mahmoud Hassan El-Ameen&lt;sup&gt;1*&lt;/sup&gt;, Manal Mohamed Elhassan Taha&lt;sup&gt;1*&lt;/sup&gt;, Siddig Ibrahim Abdelwahab&lt;sup&gt;1&lt;/sup&gt;, Asaad Khalid&lt;sup&gt;1&lt;/sup&gt;, Fatima Elfatih&lt;sup&gt;2&lt;/sup&gt;, Mona Awad Kamel&lt;sup&gt;1&lt;/sup&gt; and Bassem Yousif Sheikh&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biomedical Research Unit, Researcher at Medical Research Center, Jazan University, Jazan, Saudi Arabia.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry Medicinal and Aromatic Plants Research Institute, National Centre for Research, P. O. Box 2420 Khartoum, Sudan.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Surgery, MABL Chair, College of Medicine, Taibah University, Saudi Arabia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bassem Yousef Sheikh</style></author><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Waleed Syaed Koko</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial Effects of Thymoquinone on Entamoeba histolytica and Giardia lamblia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Entamoeba histolytica</style></keyword><keyword><style  face="normal" font="default" size="100%">Giardia lamblia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Prophetic Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Thymoquinone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">168-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Parasitic infections are a major difficulty in tropical and subtropical countries. Traditionally medicinal plants have been used in folk medicine to treat parasitic infections and are a valuable source of novel anti-parasitics. &lt;strong&gt;Objective: &lt;/strong&gt;In our search for therapeutic alternatives to anti- protozoal chemotherapy, thymoquinone, the active ingredient of Black cumin (Nigella sativa) was examined. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Thymoquinone was tested against Entamoeba histolytica and Giardia lamblia using in vitro susceptibility assays and the mortality of the parasites were then obtained using the standard calculations. The compound was also tested for 48 and 72 hours on both parasites. &lt;strong&gt;Results:&lt;/strong&gt; The current study indicate that the mortality of TQ showed 85.5%, 91.5% and 96.8% mortality on E. histolytica for 25 ppm at 24 hr, 48 and 72 hr, respectively, with IC50 2&amp;yen;10-19,. On the other hand, this natural compound showed a mortality of 82.83%, 91.76% and 96.62% mortality on G. lamblia for 25 ppm at 24 hr, 48 and 72 hr, respectively, with IC50 4.8&amp;yen;10-5. Metrondizole powder gave 70.9% mortality at 156 ppm at the same times.&lt;strong&gt; Conclusion:&lt;/strong&gt; The current results indicate that TQ is more potent on E. histolytica compared to G. lamblia. Further pharmacological studies were needed to help in the clinical presentation of thymoquinone.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">168</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Bassem Yousef Sheikh&lt;sup&gt;1&lt;/sup&gt;, Manal Mohamed Elhassan Taha&lt;sup&gt;2,&lt;/sup&gt; Waleed Syaed Koko&lt;sup&gt;3&lt;/sup&gt;, and Siddig Ibrahim Abdelwahab&lt;sup&gt;3&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Al-Moalim MA Bin Ladin (MABL) chair for Scientific Miracles of Prophetic Medicine, College of Medicine, Taibah University, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Unit of Biomedical Research, Medical Research Centre, Jazan University, P.O. Box 114 Jazan, Jazan 45142, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Medicinal and Aromatic Research Institute, National Research Centre, Khartoum, SAUDI ARABIA. 4Unit of Biomedical Research, Substance Abuse Research Centre, Jazan University, P.O. Box 114 Jazan, Jazan 45142, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Syam Mohan,</style></author><author><style face="normal" font="default" size="100%">Manal Moahmed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Rashad Bin Mohammed Alsanosy</style></author><author><style face="normal" font="default" size="100%">Hamed Karimian</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Cytotoxicity of Smokeless Tobacco (Shammah) In Hepg2 and WRL68 Cells Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro models</style></keyword><keyword><style  face="normal" font="default" size="100%">Saudi Arabia</style></keyword><keyword><style  face="normal" font="default" size="100%">Shammah.</style></keyword><keyword><style  face="normal" font="default" size="100%">Smokeless tobacco</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance Absue Research Centre</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">242-248</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Shammah is a traditional form of chewing tobacco [Smokeless tobacco, (ST)] that is commonly used in the Middle east specially Saudi Arabia (KSA), Yemen and Sudan. The cytotoxicity of Sudanese and Yemenis ST hexane and methanol extracts was evaluated using MTT assay. Annexin-V assay has been used to detect the induction of apoptosis. Luminescence based assay also been conducted to check the level of caspases enzyme. The involvement of cell cycle check point arrest has been performed using flow cytometry analysis. The current study found that ST has the capacity to induce cell toxicity in human liver cells. The inhibitory capacity of ST in HepG2 and WRL 68 has been found to be 151 &amp;plusmn; 2.5 and 305 &amp;plusmn; 11.5 &amp;mu;g/ml for 24 h. An early apoptosis induction in HepG2 cells was observed by annexin V assay, which clearly exhibited significantly increased early and late apoptosis phases both at 24 and 48 h. Both the caspases-8 and-9 level was found to be increased by the introduction of ST to HepG2 cells significantly (p&amp;lt;0.05). Moreover the ST extract was able to arrest the cell cycle check point at G2/M phase. A significantly increasing pattern of hypodiploid phases of cells also been observed, which confirm the apoptosis induction again. Collectively, results presented in this study demonstrated that the ST, which is used as a euphoritic substance of abuse also, has significant level of toxicity in human cells. Moreover the mode of cell death was found to be though programmed cell death which is closely associated with cell cycle arrest.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Hepatotoxicity,&lt;em&gt; In vitro&lt;/em&gt; models, Saudi Arabia, Smokeless tobacco, Substance Absue Research Centre, Shammah.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">242</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Siddig Ibrahim Abdelwahab&lt;sup&gt;*1&lt;/sup&gt;, Syam Mohan&lt;sup&gt;2&lt;/sup&gt;, Manal Moahmed Elhassan Taha&lt;sup&gt;2&lt;/sup&gt;, Rashad Bin Mohammed Alsanosy&lt;sup&gt;1&lt;/sup&gt; and Hamed Karimian&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Substance Abuse Research Centre, Jazan University, 11420, Jazan, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Research Center, Jazan University, 11420, Jazan, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Rashad Bin Mohammed Alsanosy</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Syam Mohan</style></author><author><style face="normal" font="default" size="100%">Manal Moahmed Elhassan Taha</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Hamed Karimian</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Cytotoxicity of Smokeless Tobacco (Shammah) In Hepg2 and WRL68 Cells Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro models</style></keyword><keyword><style  face="normal" font="default" size="100%">Saudi Arabia</style></keyword><keyword><style  face="normal" font="default" size="100%">Shammah</style></keyword><keyword><style  face="normal" font="default" size="100%">Smokeless tobacco</style></keyword><keyword><style  face="normal" font="default" size="100%">Substance Absue Research Centre</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jul-Aug 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">242-248</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Shammah is a traditional form of chewing tobacco [Smokeless tobacco, (ST)] that is commonly used in the Middle east specially Saudi Arabia (KSA), Yemen and Sudan. The cytotoxicity of Sudanese and Yemenis ST hexane and methanol extracts was evaluated using MTT assay. Annexin-V assay has been used to detect the induction of apoptosis. Luminescence based assay also been conducted to check the level of caspases enzyme. The involvement of cell cycle check point arrest has been performed using flow cytometry analysis. The current study found that ST has the capacity to induce cell toxicity in human liver cells. The inhibitory capacity of ST in HepG2 and WRL 68 has been found to be 151 &amp;plusmn; 2.5 and 305 &amp;plusmn; 11.5 &amp;mu;g/ml for 24 h. An early apoptosis induction in HepG2 cells was observed by annexin V assay, which clearly exhibited significantly increased early and late apoptosis phases both at 24 and 48 h. Both the caspases-8 and-9 level was found to be increased by the introduction of ST to HepG2 cells significantly (p&amp;lt;0.05). Moreover the ST extract was able to arrest the cell cycle check point at G2/M phase. A significantly increasing pattern of hypodiploid phases of cells also been observed, which confirm the apoptosis induction again. Collectively, results presented in this study demonstrated that the ST, which is used as a euphoritic substance of abuse also, has significant level of toxicity in human cells. Moreover the mode of cell death was found to be though programmed cell death which is closely associated with cell cycle arrest&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">242</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Siddig Ibrahim Abdelwahab&lt;sup&gt;*1&lt;/sup&gt;, Syam Mohan&lt;sup&gt;2&lt;/sup&gt;, Manal Moahmed Elhassan Taha&lt;sup&gt;2&lt;/sup&gt;, Rashad Bin Mohammed Alsanosy&lt;sup&gt;1&lt;/sup&gt; and Hamed Karimian&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Substance Abuse Research Centre, Jazan University, 11420, Jazan, Saudi Arabia 2Medical Research Center, Jazan University, 11420, Jazan, Saudi Arabia 3Department of Pharmacy, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dini Hara Triastuti</style></author><author><style face="normal" font="default" size="100%">Helmi Arifin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of the Leaves of Asam Kandis (Garcinia cowa Roxb.) on T47D Breast Cancer Cell line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asam kandis</style></keyword><keyword><style  face="normal" font="default" size="100%">Beast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">369-371</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To investigate the cytotoxic effect of ethanolic extract of the leaves of asam kandis (Garcinia cowa Roxb.) against T47D breast cancer cells. &lt;strong&gt;Methods:&lt;/strong&gt; The cytotoxicity of ethanol extract was carried out by measuring the activity of mitochondrial dehydrogenase in living cells that have ability to convert dissolved MTT pale yellow to purple formazan product. The extract was added at various concentrations (0.1, 1, 10 and 100 &amp;mu;g/mL). The level of cytotoxicity was determined by calculating the IC50 value that was based on the percentage of the cell death after 24 hours treatment with the extract. Cell morphological changes were observed by using inverted microscope. &lt;strong&gt;Results:&lt;/strong&gt; The IC50 value showed that ethanol extract of leaves of asam kandis could resist T47D breast cancer cells with IC50 6.13 &amp;plusmn; 3.51 &amp;mu;g/mL. The statistic results proved that ethanol extract of the leaves of asam kandis could inhibit the growth of T47D breast cancer cells significantly at concentrations of 10 &amp;mu;g/mL and 100 &amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results suggest that ethanol extract of the leaves of asam kandis was potential source of herbal medicine for cancer-related ailments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">369</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni*, Dini Hara Triastuti and Helmi Arifin&lt;/strong&gt; Department of Pharmacy, Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Rashad Elsanousi</style></author><author><style face="normal" font="default" size="100%">Bassem Y. Sheikh</style></author><author><style face="normal" font="default" size="100%">Mahmood Ameen Abdulla</style></author><author><style face="normal" font="default" size="100%">Saif Eldeen Babiker</style></author><author><style face="normal" font="default" size="100%">Husham Elraih</style></author><author><style face="normal" font="default" size="100%">Eldaw Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">157-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Sider (&lt;em&gt;Ziziphus spina-christi&lt;/em&gt; (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. &lt;strong&gt;Aim of the study:&lt;/strong&gt; The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95% ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. Results: Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax). &lt;strong&gt;Conclusion: &lt;/strong&gt;Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manal Mohamed Elhassan Taha</style></author><author><style face="normal" font="default" size="100%">Siddig Ibrahim Abdelwahab</style></author><author><style face="normal" font="default" size="100%">Rashad Elsanousi</style></author><author><style face="normal" font="default" size="100%">Bassem Y. Sheikh</style></author><author><style face="normal" font="default" size="100%">Mahmood Ameen Abdulla</style></author><author><style face="normal" font="default" size="100%">Saif Eldeen Babiker</style></author><author><style face="normal" font="default" size="100%">Husham Elraih</style></author><author><style face="normal" font="default" size="100%">Eldaw Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Sidr Honey on the prevention of ethanol-induced gatroulcerogenesis: role of antioxidant and antiapoptotic mechanism</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiapoptotic Mechanism</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastro protection</style></keyword><keyword><style  face="normal" font="default" size="100%">monofloral nectar</style></keyword><keyword><style  face="normal" font="default" size="100%">Sidr Honey.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">13th Feb, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">157-164</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Sider &lt;em&gt;(Ziziphus spina-christi&lt;/em&gt; (L.) Desf.) Honey has been used for the treatment of gastrointestinal disorders including peptic ulcer. &lt;strong&gt;Aim of the study:&lt;/strong&gt; The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. The mechanism of the antiulcer effect of sider honey was studied placing emphasis on its role to block oxidative damage and apoptosis during ethanol-induced gastric ulceration in rats. &lt;strong&gt;Materials and methods: &lt;/strong&gt;Experimental animals were orally treated with sidr honey (100, 250 and 500 mg/kg, respectively) or omeprazole and subsequently exposed to 95%ethanol (5 mL/Kg, orally) to induce acute gastroulcerogenesis. Effectiveness of sidr honey was evaluated using ulcer index, pH of gastric juice, mucus content, morphological analyses, glutathione assay and malondialdehyde level. The anti-apoptotic role of sidr honey was studied using immunohistochemical staining of gastric tissues using monoclonal antibodies of Bax pathway. &lt;strong&gt;Results: &lt;/strong&gt;Dose-response studies in ethanol-induced ulcer indicate that sidr honey significantly blocks gastric lesions at lower dose (100 mg/kg). Lipid peroxidation and glutathione depletion were significantly inhibited by sidr honey. Sidr honey modulated the immuno-expression of mitochondrial associated protein (Bax).&lt;strong&gt; Conclusion:&lt;/strong&gt; Thus, sider honey plays a considerable role in gastro protection by acting as a potent antioxidant and antiapoptotic agent. Future study is required to explore its potential clinical usage.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Antiapoptotic Mechanism, Antioxidant Agents, Gastro protection, Monofloral Nectar, Sidr Honey.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manal Mohamed Elhassan Taha&lt;sup&gt;1*&lt;/sup&gt;, Siddig Ibrahim Abdelwahab&lt;sup&gt;1&lt;/sup&gt;, Rashad Elsanousi&lt;sup&gt;1&lt;/sup&gt;, Bassem Y. Sheikh&lt;sup&gt;2&lt;/sup&gt;, Mahmood Ameen Abdulla&lt;sup&gt;3&lt;/sup&gt;, Saif Eldeen Babiker&lt;sup&gt;1&lt;/sup&gt;, Husham Elraih&lt;sup&gt;1&lt;/sup&gt;, Eldaw Mohamed&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Research Centre, Jazan University, Jazan, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;MABL Scientific Chair, Department of Surgery, College of Medicine, Taibah University, Saudi Arabia&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR.</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of Plectranthusamboinicusto test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC&lt;sub&gt;50&lt;/sub&gt; values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01 &amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;sup&gt;b&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan</style></author><author><style face="normal" font="default" size="100%">Gunasekar Ramya</style></author><author><style face="normal" font="default" size="100%">Madhusudhanan Gogulramnath</style></author><author><style face="normal" font="default" size="100%">Rajarajeswaran Jayakumar</style></author><author><style face="normal" font="default" size="100%">M.S. Kanthimathi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of cytotoxic, DNA protecting and LPS induced MMP-9 down regulation activities of Plectranthus amboinicus (Lour) Spreng. essential oil.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antigenotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">RT- PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Zymogram</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt;Plectranthus amboinicus&lt;/em&gt; (Lour) Spreng is a known medicinal plant used in Siddha and Ayurveda medicines in India. It has enormous medicinal potential to treat various diseases. &lt;strong&gt;Methods:&lt;/strong&gt; The present study focused on the use of essential oil obtained from the leaves of &lt;em&gt;Plectranthus amboinicus&lt;/em&gt; to test cytotoxicity against breast (MCF-7) and colorectal (HT-29) cancer cell lines, to protect DNA from H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; induced genotoxicity through comet assay and to treat inflammation in lipopolysaccharide (LPS) induced over expression of matrix metalloproteinase-9 (MMP-9) in human peripheral blood mononuclear cells (PBMCs) by gelatin zymogram and inhibition at transcriptional level confirmed using RT-PCR (reverse transcriptase polymerase chain reaction). &lt;strong&gt;Results:&lt;/strong&gt; Cytotoxicity of essential oil against MCF-7 and HT-29 cancer cell lines revealed the IC50 values of 53 &amp;plusmn; 0.01 and 87 &amp;plusmn; 0.01&amp;mu;g/mL respectively. At 200 &amp;mu;g/mL essential oil protected against 75% of DNA damage in 3T3-L1 fibroblast cells. Essential oil showed significant reduction in production of MMP-9 in a concentration dependent manner. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, the results showed that essential oil of &lt;em&gt;P. amboinicus&lt;/em&gt; is a potent bioactive substance and it could be used in herbal medicine preparations.&lt;br /&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Essential oil , Cytotoxicity , Antigenotoxicity, Zymogram, RT- PCR.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Ramaraj Thirugnanasampandan, Gunasekar Ramya, Madhusudhanan Gogulramnath, Rajarajeswaran Jayakumar, M.S. Kanthimathi</style></custom1><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramaraj Thirugnanasampandan&lt;sup&gt;a,*&lt;/sup&gt;, Gunasekar Ramya&lt;sup&gt;a&lt;/sup&gt;, Madhusudhanan Gogulramnath&lt;sup&gt;a&lt;/sup&gt;, Rajarajeswaran Jayakumar&lt;sup&gt;b&lt;/sup&gt;, M.S. Kanthimathi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Laboratory of Plant Tissue Culture and Molecular Bioprospection, PG and Research Department of Biotechnology, Kongunadu Arts and Science College, GN Mills, Coimbatore, Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramya Bashyam</style></author><author><style face="normal" font="default" size="100%">Malarvili Thekkumalai</style></author><author><style face="normal" font="default" size="100%">Velavan Sivanandham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytoconstituents of Bryonopsis laciniosa fruit by UV-Visible Spectroscopy and FTIR analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bryonia laciniosa</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytonutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">165-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To Investigate the phytochemicals present in &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit. &lt;strong&gt;Methodology: &lt;/strong&gt;Qualitative, Quantitative screening, Compound Identification by UV-Visible method and identification of functional group of the active chemical components were followed by standard procedures. &lt;strong&gt;Result: &lt;/strong&gt;The results showed the presence of phytonutrients like reducing sugar, terpenoids, triterpenoids, aminoacids, anthroquinone, polyphenols, glycosides, anthocyanins, tannins, coumarins, emodins, saponins, total alkaloids, total flavonoids, lignin and serpentine. These substances may be responsible for the health related properties of the plant which are based on antioxidant, anticancer, antipyretic, antiaphoretic, antidiabetic, anti-inflammation, antiheamatisum, antimicrobial and antiviral activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study supports the popular use of &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit in preparation of various pharmaceutical formulations for human welfare.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ramya Bashyam&lt;sup&gt;1&lt;/sup&gt;, Malarvili Thekkumalai&lt;sup&gt;2&lt;/sup&gt; and Velavan Sivanandham&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Madudupandiyar College, Thanjavur, Tamil Nadu, South India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramya Bashyam</style></author><author><style face="normal" font="default" size="100%">Malarvili Thekkumalai</style></author><author><style face="normal" font="default" size="100%">Velavan Sivanandham</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytoconstituents of Bryonopsis laciniosa fruit by UV-Visible Spectroscopy and FTIR analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bryonia laciniosa</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytonutrients</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">165-170</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To Investigate the phytochemicals present in &lt;em&gt;Bryonopsis laciniosa&lt;/em&gt; fruit. &lt;strong&gt;Methodology:&lt;/strong&gt; Qualitative, Quantitative screening, Compound Identification by UV-Visible method and identification of functional group of the active chemical components were followed by standard procedures.&lt;strong&gt; Result:&lt;/strong&gt; The results showed the presence of phytonutrients like reducing sugar, terpenoids, triterpenoids, aminoacids, anthroquinone, polyphenols, glycosides, anthocyanins, tannins, coumarins, emodins, saponins, total alkaloids, total flavonoids, lignin and serpentine. These substances may be responsible for the health related properties of the plant which are based on antioxidant,anticancer, antipyretic, antiaphoretic, antidiabetic, anti-inflammation, antiheamatisum, antimicrobial and antiviral activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study supports the popular use of&lt;em&gt; Bryonopsis laciniosa&lt;/em&gt; fruit in preparation of various pharmaceutical formulations for human welfare.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Bryonia laciniosa,&lt;/em&gt; FTIR, Phytochemical screening, Phytonutrients, UV-Vis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">165</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramya Bashyam&lt;sup&gt;1&lt;/sup&gt;, Malarvili Thekkumalai&lt;sup&gt;2&lt;/sup&gt; and Velavan Sivanandham&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;P.G. and Research Department of Biochemistry, Rajah Serfoji Govt. College [Autonomous], Thanjavur-613 005, Tamil Nadu, South India.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Madudupandiyar College, Thanjavur, Tamil Nadu, South India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">Jorge Triana</style></author><author><style face="normal" font="default" size="100%">José L Eiroa</style></author><author><style face="normal" font="default" size="100%">José M Padrón</style></author><author><style face="normal" font="default" size="100%">Gabriela B Plata</style></author><author><style face="normal" font="default" size="100%">Ernesto V Abel-Santos</style></author><author><style face="normal" font="default" size="100%">Luis A. Báez</style></author><author><style face="normal" font="default" size="100%">Diana C Rodríguez</style></author><author><style face="normal" font="default" size="100%">Marco A Jiménez</style></author><author><style face="normal" font="default" size="100%">María F Pérez-Pujols</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flavonoids from Eupatorium illitum and Their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-Hydroxybenzoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">7-Methoxy-aromadendrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ermanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eupatorium illitum</style></keyword><keyword><style  face="normal" font="default" size="100%">Kumatakenin</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">178-181</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To isolate the chemical constituents of the aerial parts from&lt;em&gt; Eupatorium illitum&lt;/em&gt;, elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of &lt;em&gt;Eupatorium illitum&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The flavonoids Kumatakenin (&lt;strong&gt;1&lt;/strong&gt;), Ermanin (&lt;strong&gt;2&lt;/strong&gt;), 7-methoxy-aromadendrin (&lt;strong&gt;3&lt;/strong&gt;) and Naringenin (&lt;strong&gt;4&lt;/strong&gt;), together with 4-hydroxybenzoic acid (&lt;strong&gt;5&lt;/strong&gt;) were isolated. Compounds &lt;strong&gt;1, 2, 4&lt;/strong&gt; and &lt;strong&gt;5&lt;/strong&gt; were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for &lt;strong&gt;5&lt;/strong&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compounds 1-5 are reported for first time from &lt;em&gt;Eupatorium illitum&lt;/em&gt;. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">178</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Qu&amp;iacute;rico A Castillo&lt;sup&gt;*1,2&lt;/sup&gt;, Jorge Triana&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; L Eiroa&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; M Padr&amp;oacute;n&lt;sup&gt;4&lt;/sup&gt;, Gabriela B Plata&lt;sup&gt;4&lt;/sup&gt;, Ernesto V Abel-Santos&lt;sup&gt;5&lt;/sup&gt;, Luis A. B&amp;aacute;ez&lt;sup&gt;1&lt;/sup&gt;, Diana C Rodr&amp;iacute;guez&lt;sup&gt;1&lt;/sup&gt;, Marco A Jim&amp;eacute;nez&lt;sup&gt;2&lt;/sup&gt;, Mar&amp;iacute;a F P&amp;eacute;rez-Pujols&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;3Departamento de Qu&amp;iacute;mica, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Org&amp;aacute;nica &amp;ldquo;Antonio Gonz&amp;aacute;lez&amp;rdquo; (IUBO-AG), Centro de Investigaciones Biom&amp;eacute;dicas de Canarias (CIBICAN), C/Astrof&amp;iacute;sico Francisco S&amp;aacute;nchez 2, 38206. La Laguna, Spain.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Quírico A Castillo</style></author><author><style face="normal" font="default" size="100%">Jorge Triana</style></author><author><style face="normal" font="default" size="100%">José L Eiroa</style></author><author><style face="normal" font="default" size="100%">José M Padrón</style></author><author><style face="normal" font="default" size="100%">Gabriela B Plata</style></author><author><style face="normal" font="default" size="100%">Ernesto V Abel-Santos</style></author><author><style face="normal" font="default" size="100%">Luis A. Báez</style></author><author><style face="normal" font="default" size="100%">Diana C Rodríguez</style></author><author><style face="normal" font="default" size="100%">Marco A Jiménez</style></author><author><style face="normal" font="default" size="100%">María F Pérez-Pujols</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Flavonoids from Eupatorium illitum and Their Antiproliferative Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-Hydroxybenzoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">7-Methoxy-aromadendrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ermanin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eupatorium illitum</style></keyword><keyword><style  face="normal" font="default" size="100%">Kumatakenin</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">178-181</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To isolate the chemical constituents of the aerial parts from &lt;em&gt;Eupatorium illitum,&lt;/em&gt; elucidate their structures and evaluate their antiproliferative activity on human cancer cell lines. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The ethanolic extract of&lt;em&gt; Eupatorium illitum&lt;/em&gt; afforded five compounds, which were characterized using spectroscopic techniques and by comparison with data from the literature. Antiproliferative activities of selected isolates were evaluated.&lt;strong&gt; Results:&lt;/strong&gt; The flavonoids Kumatakenin (&lt;strong&gt;1&lt;/strong&gt;), Ermanin (&lt;strong&gt;2&lt;/strong&gt;), 7-methoxy-aromadendrin (&lt;strong&gt;3&lt;/strong&gt;) and Naringenin (&lt;strong&gt;4&lt;/strong&gt;), together with 4-hydroxybenzoic acid (&lt;strong&gt;5&lt;/strong&gt;) were isolated. Compounds &lt;strong&gt;1, 2, 4&lt;/strong&gt; and &lt;strong&gt;5&lt;/strong&gt; were evaluated for their antiproliferative activity on the human cancer cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), and T-47D (breast) presenting a wide range of bioactivities. In general, best results were observed for &lt;strong&gt;5&lt;/strong&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compounds &lt;strong&gt;1-5&lt;/strong&gt; are reported for first time from &lt;em&gt;Eupatorium illitum&lt;/em&gt;. Isolated phytochemicals show moderate to low antiproliferative activities when evaluated on the aforementioned human cancer cell lines.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Eupatorium illitum&lt;/em&gt;, Ermanin, 4-Hydroxybenzoic acid, Kumatakenin, 7-Methoxy-aromadendrin, Naringenin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">178</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Qu&amp;iacute;rico A Castillo&lt;sup&gt;*1,2&lt;/sup&gt;, Jorge Triana&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; L Eiroa&lt;sup&gt;3&lt;/sup&gt;, Jos&amp;eacute; M Padr&amp;oacute;n&lt;sup&gt;4&lt;/sup&gt;, Gabriela B Plata&lt;sup&gt;4&lt;/sup&gt;, Ernesto V Abel-Santos&lt;sup&gt;5&lt;/sup&gt;, Luis A. B&amp;aacute;ez&lt;sup&gt;1&lt;/sup&gt;, Diana C Rodr&amp;iacute;guez&lt;sup&gt;1&lt;/sup&gt;, Marco A Jim&amp;eacute;nez&lt;sup&gt;2&lt;/sup&gt;, Mar&amp;iacute;a F P&amp;eacute;rez-Pujols&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Qu&amp;iacute;mica, Facultad de Ciencias, Universidad Aut&amp;oacute;noma de Santo Domingo, Ciudad Universitaria, Santo Domingo D.N., Dominican Republic.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Qu&amp;iacute;mica, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017 Las Palmas de Gran Canaria, Canary Islands, Spain.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;BioLab, Instituto Universitario de Bio-Org&amp;aacute;nica &amp;ldquo;Antonio Gonz&amp;aacute;lez&amp;rdquo; (IUBO-AG), Centro de Investigaciones Biom&amp;eacute;dicas de Canarias (CIBICAN), C/Astrof&amp;iacute;sico Francisco S&amp;aacute;nchez 2, 38206. La Laguna, Spain.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry and Biochemistry, University of Nevada-Las Vegas, Las Vegas, NV 89154.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">VR Patil</style></author><author><style face="normal" font="default" size="100%">VM Thakare</style></author><author><style face="normal" font="default" size="100%">VS Joshi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory Activity of Atalantia monophylla DC. roots</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atalantia monophylla</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell-mediated immune response</style></keyword><keyword><style  face="normal" font="default" size="100%">Humoral immune response</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">37-43</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The objective of the present study was to evaluate the immunomodulatory activity of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;, were administered orally, in the doses of 10 mg/kg and 30 mg/kg, to evaluate the immunomodulatory activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Methanolic fraction showed most significant effect when compared with control group, in the dose of 30 mg/kg, in the &lt;em&gt;E.Coli&lt;/em&gt; induced abdominal sepsis and Carbon Clearence Test as models for non-specific immune response. In the models of the Specific immune response, cell mediated immune response to SRBC-delayed type of hypersensitivity (DTH) the methanolic fraction in the dose 30 mg/kg, when compared with control group, showed most significant effect on decrease in footpad edema after treatment. &lt;strong&gt;Results:&lt;/strong&gt; Humoral immune response was assessed by Sheep erythrocyte agglutination test, in which the Methanolic fraction of &lt;em&gt;Atalantia monophylla&lt;/em&gt; in the dose of 30 mg/kg showed most significant (p&amp;lt;0.05) increase in antibody titer after treatment when compared with control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present investigation reports that the Methanolic fraction of the ethanolic extract of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;, in the dose of 30 mg/kg showed most significant immunomodulatory activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;V. R. Patil, V. M. Thakare, V.S. Joshi&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy, TVES&amp;rsquo;s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur &amp;ndash; 425503, Dist- Jalgaon, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">V. R. Patil</style></author><author><style face="normal" font="default" size="100%">V. M. Thakare</style></author><author><style face="normal" font="default" size="100%">V.S. Joshi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunomodulatory Activity of Atalantia monophylla DC. roots</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atalantia monophylla</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell-mediated immune response</style></keyword><keyword><style  face="normal" font="default" size="100%">Humoral immune response.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">37-43</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The objective of the present study was to evaluate the immunomodulatory activity of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;. In the present study Pet. Ether, Chloroform and Methanolic fractions of the ethanolic extract of the roots of&lt;em&gt; Atalantia monophylla&lt;/em&gt;, were administered orally, in the doses of 10 mg/kg and 30 mg/kg, to evaluate the immunomodulatory activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Methanolic fraction showed most significant effect when compared with control group, in the dose of 30 mg/kg, in the&lt;em&gt; E.Coli&lt;/em&gt; induced abdominal sepsis and Carbon Clearence Test as models for non-specific immune response. In the models of the Specific immune response, cell mediated immune response to SRBC - delayed type of hypersensitivity (DTH) the methanolic fraction in the dose 30 mg/kg, when compared with control group, showed most significant effect on decrease in footpad edema after treatment. &lt;strong&gt;Results:&lt;/strong&gt; Humoral immune response was assessed by Sheep erythrocyte agglutination test, in which the Methanolic fraction of&lt;em&gt; Atalantia monophylla &lt;/em&gt;in the dose of 30 mg/kg showed most significant (p&amp;lt;0.05) increase in antibody titer after treatment when compared with control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present investigation reports that the Methanolic fraction of the ethanolic extract of the roots of &lt;em&gt;Atalantia monophylla&lt;/em&gt;, in the dose of 30 mg/kg showed most significant immunomodulatory activity.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Atalantia monophylla&lt;/em&gt;, Immunomodulatory, Phagocytosis, Cell-mediated immune response, Humoral immune response.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">V. R. Patil, V. M. Thakare, V.S. Joshi</style></custom1><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;V. R. Patil, V. M. Thakare, V.S. Joshi&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy, TVES&amp;rsquo;s Honorable Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur &amp;ndash; 425503, Dist- Jalgaon, Maharashtra, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lakshmi Thangavelu</style></author><author><style face="normal" font="default" size="100%">Rajendran Ramasamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Acetyl Cholinesterase Inhibitory assay of Acacia catechu Willd Ethanolic Seed Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acacia catechu seed</style></keyword><keyword><style  face="normal" font="default" size="100%">Acetyl cholinesterase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Alzheimer’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurodegenerative</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometric analysis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">280-282</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim &amp;amp; objective:&lt;/strong&gt; The aim of this study was to evaluate acetyl cholinesterase inhibitory activity of &lt;em&gt;Acacia catechu &lt;/em&gt;ethanolic seed extract to introduce a new source for management of Alzheimer&amp;rsquo;s disease. &lt;strong&gt;Background:&lt;/strong&gt; Alzheimer&amp;rsquo;s disease is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elderly population and is estimated to account for 50&amp;ndash;60% of dementia cases in persons over 65 years of age. It is likely that the inhibition of acetyl cholinesterase by &lt;em&gt;Acacia catechu&lt;/em&gt; ethanolic seed extract that is rich in flavonoids and antioxidants may aid in the protection of neurodegenerative disorders and ultimately Alzheimer&amp;rsquo;s disease. &lt;strong&gt;Methods:&lt;/strong&gt; Anti cholinesterase activity is determined by adopting &lt;em&gt;In vitro &lt;/em&gt;standard protocol. &lt;strong&gt;Results:&lt;/strong&gt; According to the obtained results, the inhibitory activity (IC&lt;sub&gt;50&lt;/sub&gt; values, &amp;mu;g /ml) of extracts was 204.38 &amp;plusmn; 2.54 &amp;mu;g/ ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results indicated and confirmed the traditional use of &lt;em&gt;Acacia catechu&lt;/em&gt; ethanolic seed extract for management of central nervous system disorders. It showed the moderate activity in inhibition of acetyl cholinesterase at various concentrations. However, further investigations on identification of active components in the extracts are needed.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">280</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Lakshmi Thangavelu&lt;sup&gt;*1&lt;/sup&gt; and Rajendran Ramasamy&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Chennai, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Green Chem Herbal Extracts and Formulations, Bangalore, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kavitha R</style></author><author><style face="normal" font="default" size="100%">Chittibabu CV</style></author><author><style face="normal" font="default" size="100%">Subha TS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation of Indigenous Medicinal Plant Kedrostis foetidissima (Jacq.) Cogn</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kedrostis foetidissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Powder microscopy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">52-57</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ingeneral, members of Cucurbitaceae are well exploited for their medicinal, economic and culinary values, however few of them are less exploited. The present study deals with pharamcognostical evaluation of one such plant namely &lt;em&gt;Kedrostis foetidissima &lt;/em&gt;(Jacq.) Cogn.called as Appakovai in Tamil. Methods: Pharmacognostic evaluations were carried out by organoleptic evaluation, anatomical studies and powder microscopy of leaves, roots and root tubers. &lt;strong&gt;Results:&lt;/strong&gt; Organoleptic evaluation revealed that the characteristic white tubers, as storage organs, leaves exhibited a foetidodour when crushed. Anatomy of leaves showed lithocysts and anomocytic stomata, root showed the presence of fissured periderm and cleaved vascular bundles and that of root tubers showed 3 or 4 exarch xylem. Powder microscopy of root tubers showed narrow and wide fibers; long, narrow and drum shaped vessels and scattered sclereids. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present Pharmacognostic and Powder microscopic studiesreveals that, the characteristic features of this plantparts resembles, the other members of cucurbitaceae.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kavitha R&lt;sup&gt;1,2*&lt;/sup&gt; Chittibabu CV&lt;sup&gt;2,3*&lt;/sup&gt;, SubhaTS&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;a1&lt;/sup&gt;PG Department of Botany, Bharathi Women&amp;rsquo;s College, Chennai 600 108., Tamil Nadu, India.&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Prist University,Tanjore., Tamil Nadu, India.&lt;br /&gt;
&lt;sup&gt;3&lt;/sup&gt;PG Department of Botany, Nandhanam Arts College for Men, Chennai.600035., Tamil Nadu, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kavitha R</style></author><author><style face="normal" font="default" size="100%">Chittibabu CV</style></author><author><style face="normal" font="default" size="100%">Subha TS</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation of Indigenous Medicinal Plant Kedrostis foetidissima (Jacq.) Cogn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kedrostis foetidissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Powder microscopy.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">52-57</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Ingeneral, members of Cucurbitaceae are well exploited for their medicinal, economic and culinary values,however few of them are less exploited.The present study deals with pharamcognostical evaluation ofone such plant namely &lt;em&gt;Kedrostis foetidissima &lt;/em&gt;(Jacq.) Cogn.called as Appakovai in Tamil. &lt;strong&gt;Methods:&lt;/strong&gt; Pharmacognostic evaluationswere carried out by organoleptic evaluation, anatomical studies and powder microscopy of leaves, roots and root tubers. &lt;strong&gt;Results: &lt;/strong&gt;Organoleptic evaluation revealed that the characteristic white tubers, as storage organs, leaves exhibited a foetid odour when crushed. Anatomy of leaves showed lithocysts and anomocytic stomata,root showed the presence of fissured periderm and cleaved vascular bundlesand that of root tubers showed 3 or 4 exarch xylem. Powder microscopy of root tubers showed narrow and wide fibers; long, narrow and drum shaped vessels and scattered sclereids. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present Pharmacognostic and Powder microscopic studiesreveals that, the characteristic features of this plantparts resembles, the other members of cucurbitaceae.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Kedrostis foetidissima, Pharmacognosy, Powder microscopy&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Kavitha R, Chittibabu CV, SubhaTS</style></custom1><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kavitha R&lt;sup&gt;1,2*&lt;/sup&gt; Chittibabu CV&lt;sup&gt;2,3*&lt;/sup&gt;, SubhaTS&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG Department of Botany, Bharathi Women&amp;rsquo;s College, Chennai 600 108., Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Prist University,Tanjore., Tamil Nadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;PG Department of Botany, Nandhanam Arts College for Men, Chennai.600035., Tamil Nadu, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thangavelu Lakshmi</style></author><author><style face="normal" font="default" size="100%">Rajendran Ramasamy</style></author><author><style face="normal" font="default" size="100%">Rathinam Thirumalaikumaran</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Phytochemical analysis and In vitro Antioxidant, FTIR Spectroscopy, Anti-diabetic activity of Acacia catechu ethanolic seed extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acacia catechu seed</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha glucosidase</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">FTIR Spectroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">356-362</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the preliminary phytochemical analysis and in vitro antioxidant activity, anti-diabetic effect of ethanolic seed extract of Acacia catechu against the alpha amylase and alpha glucosidase digestive enzymes in the pancreas and small intestine. &lt;strong&gt;Methods:&lt;/strong&gt; Preliminary phytochemical analysis was done by adopting the method of Evans. Antioxidant assay is performed by DPPH, ABTS and FRAP assay, Anti diabetic activity was determined by modified method of miller, the extract at different concentrations was tested for mammalian alpha amylase and alpha glucosidase enzyme inhibitory assay under the controlled experimental conditions and subjected to determination of absorbance. &lt;strong&gt;Results: &lt;/strong&gt;The present study reveals the presence of few secondary metabolites and the extract exhibits potent Antioxidant activity and a concentration dependent inhibition of Alpha amylase and Alpha glucosidase.&lt;strong&gt; Conclusion:&lt;/strong&gt; From the present study it can be concluded that ethanolic seed extract of Acacia catechu possessed marked in vitro antioxidant and anti-diabetic effect. The effect was plausibly due to the presence of phenolic contents of Acacia catechu&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">356</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Thangavelu Lakshmi&lt;sup&gt;*1&lt;/sup&gt;, Rajendran Ramasamy&lt;sup&gt;2&lt;/sup&gt; and Rathinam Thirumalaikumaran&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Chennai, India. 2Department of R and D, Green Chem Herbal Extracts and Formulations, Bangalore, India. 3Department of Pharmacognosy, Faculty of Pharmacy, Sree Ramachandra Medical College and Research Institute, chennai, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammadi M</style></author><author><style face="normal" font="default" size="100%">Majd A</style></author><author><style face="normal" font="default" size="100%">Nejadsattari T</style></author><author><style face="normal" font="default" size="100%">Hashemi M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Anticancer Activities of Ocimum basilicum L. cv. Dark Opal (Lamiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-(4</style></keyword><keyword><style  face="normal" font="default" size="100%">4 diphenyltetrazolium bromide assay</style></keyword><keyword><style  face="normal" font="default" size="100%">5-dimethylthiazol-2yl)-2</style></keyword><keyword><style  face="normal" font="default" size="100%">A549 Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Digera muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cell line.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">S</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants used in folk and traditional medicines have been accepted as therapeutic drug development in modern medicine.Although manystudies have been focused on Lamiaceae family,few studies on medical effects of purple basil have been performed until now. &lt;strong&gt;Objective:&lt;/strong&gt; Ocimum basilicum cv. dark opal was chosen for this study as it has been used in Persian traditional medicine and many Iranian dishes. It was considered important to determine the cytotoxicity effect andthe reductive capacity of the purple basil oils and extracts, as this may indicate their potential as antioxidants. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The reducing power activity of both essential oils of the leaves (before flowering) and the seeds and also methanolic extracts of roots and aerial parts (stem-leaf) (collected prior flowering), and flowers were determined by utilizing of FRAP. Also the MTT assay has been used in order to consider in vitro cytotoxicity of essential oils and extracts on cancerous cell line (MCF-7). Moreover, the extracts were analyzed by HPLC to comprise the rate of some phenolic compounds.&lt;strong&gt; Results: &lt;/strong&gt;The purple basil extracts have more powerful antioxidant activity than the essential oils. MCF-7 revealed to have a meaningful cell death when compared with controls, and the oils were found to be more effective than the extracts. Also the phytochemical analysis of the extracts has led to the identification of 3 phenolic compounds (Rosmarinic acid, p-Coumaric acid and Ferulic acid). &lt;strong&gt;Conclusion:&lt;/strong&gt; Our study tends to validate the traditional use of this medicinal herb as complementary and alternative medicine.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Words:&lt;/strong&gt; purple basil, antioxidant, MCF-7, HPLC.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shazia Usmani&lt;sup&gt;*1&lt;/sup&gt;, Arshad Hussain&lt;sup&gt;1&lt;/sup&gt;, A. H. A. Farooqui&lt;sup&gt;2&lt;/sup&gt;, Mohammed Arshad&lt;sup&gt;3&lt;/sup&gt;, Sahabjada Siddiqui&lt;sup&gt;3&lt;/sup&gt;, Mohammed Ahmad&lt;sup&gt;1&lt;/sup&gt;, Shadma Wahab&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India, &lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Faculty of Biosciences, Integral University, Lucknow, Uttar Pradesh, India, &lt;sup&gt;3&lt;/sup&gt;Department of Zoology, Faculty of Life Sciences, Lucknow University, Lucknow, Uttar Pradesh, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S. A. Thube</style></author><author><style face="normal" font="default" size="100%">M. J. Patil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Wound Healing Potential of Some Indian Herbal Extracts and it’s Formulation in Acne Vulgaris</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acne</style></keyword><keyword><style  face="normal" font="default" size="100%">excision model</style></keyword><keyword><style  face="normal" font="default" size="100%">incision model</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2nd July 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">37-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt;&lt;em&gt;Butea monosperma&lt;/em&gt;, &lt;em&gt;Barleria prionitis&lt;/em&gt;, &lt;em&gt;Casuarina equisetifolia&lt;/em&gt;, &lt;em&gt;Dalbergia sissoo&lt;/em&gt;, and &lt;em&gt;Lagenaria siceraria&lt;/em&gt; are reported to possess anti-acne, anti-infl ammatory, anti-ulcer, and wound healing activity. The present work is aimed at evaluating the wound healing potential of these plant materials in acne vulgaris. &lt;strong&gt;Methodology:&lt;/strong&gt; Individual gel formulations containing extracts of the above mentioned drugs and their polyherbal gels were evaluated by excision and incision wound model (&lt;em&gt;in vivo&lt;/em&gt;) in Sprague Dawley rats.&lt;strong&gt; Results:&lt;/strong&gt; The individual gel formulations showed signifi cant reduction in wound size when compared with the untreated group. The rates of wound closure after the application of the gels were compared with the untreated wounds. The polyherbal formulation containing all the extracts was found to be more benefi cial when compared to remaining treated groups. Healing under scab and formation of normal epithelial cells were better than other individual formulations. As well as vascular changes, cellular infi ltration, and necrosis were found less. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the results, it may be concluded that the plants are endowed with signifi cant wound healing activity, thereby justifying its traditional medicinal use in acne vulgaris as a separate entity and in combination. Chemical components such as tannins, fl avonoids, saponins, and alkaloids present in the extracts can be responsible for the foresaid activity.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Acne, excision model, incision model, wound healing.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;S. A. Thube&lt;sup&gt;1*&lt;/sup&gt;, M. J. Patil&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, M.C.E. Society&amp;rsquo;s Allana College of Pharmacy, Pune, Maharashtra, India,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, M.M&amp;rsquo;s College of Pharmacy, Tathawade, Pune, Maharashtra, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chuanchom Khuniad</style></author><author><style face="normal" font="default" size="100%">Worathat Thitikornpong</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic evaluation and chrysazin quantitation of Xyris indica flowering heads</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Chrysazin</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic specification</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantitative analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Xyris indica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">16-22</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The present study aimed to establish quality specification of &lt;em&gt;Xyris indica&lt;/em&gt; L. flowering heads. The pharmacognostic parameters were investigated. Chrysazin contents were analyzed by TLC image analysis using ImageJ software compared to TLC-densitometry. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;X. indica&lt;/em&gt; flowering heads from 15 different sources in Thailand were collected. Morphological and physicochemical parameters were characterized. Chrysazin was successively extracted and determined by TLC image analysis using ImageJ software and TLC-densitometry. &lt;strong&gt;Results:&lt;/strong&gt; Macroscopic study was illustrated as whole plant drawing. The microscopic study showed fragment of corolla, seeds, pollen grain and staminode. The pharmacognostic parameters revealed that the loss on drying, total ash, acid-insoluble ash and water content should be not more than 6.90, 2.50, 0.41, and 11.12 of % dry weight respectively while water and ethanol-soluble extractive values should be not less than 6.59 and 4.03 of % dry weight respectively. TLC fingerprint revealed clearly chrysazin yellow fluorescent band at 365 nm. Chrysazin quantitation by TLC image analysis and TLC densitometry were developed and validated. Chrysazin content was 0.022 &amp;plusmn; 0.001 % dry weight by both methods. There was no statistically significantly difference between these methods. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study provided pharmacognostic specification and chrysazin content of &lt;em&gt;X. indica&lt;/em&gt; flowering heads that can be used for basic quality control and standardization of plant material. TLC image analysis using ImageJ software showed reliable and convenient for analysis of chrysazin content in this crude drug.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Xyris indica&lt;/em&gt;, Pharmacognostic specification, Chrysazin, Quantitative analysis, Antimicrobial activities&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Chuanchom Khuniad&lt;sup&gt;a&lt;/sup&gt;, Worathat Thitikornpong&lt;sup&gt;b&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;a*&lt;/sup&gt; and Nijsiri Ruangrungsi&lt;sup&gt;a,c&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;College of Public Health Sciences, Chulalongkorn University, Bangkok-10330, Thailand&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok-10330, Thailand&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;c&lt;/sup&gt;Faculty of Pharmacy, Rangsit University, Pathumthani-12000, Thailand.&lt;/p&gt;</style></auth-address></record></records></xml>