<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ranjini HS</style></author><author><style face="normal" font="default" size="100%">Kadmad Abdul Hameed Mohamed Azar</style></author><author><style face="normal" font="default" size="100%">S Fayazul Haq</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Vinodakumar HR</style></author><author><style face="normal" font="default" size="100%">Akash A</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Oral Toxicity Evaluation of Hydroalcoholic Extract of Salvia Officinalis Roots in Wistar Rats as per OECD 423 TG</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology</style></keyword><keyword><style  face="normal" font="default" size="100%">heart</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Salvia officinalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">577-582</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In this study, we assessed the hydroalcoholic root extract of &lt;em&gt;Salvia officinalis &lt;/em&gt;oral acute toxicity investigation using an animal model. &lt;strong&gt;Methods: &lt;/strong&gt;The investigation of acute oral toxicity was conducted using OECD 423 guidelines. The Institutional Animal Ethics Committee approved the study (IAEC). A single oral dose of &lt;em&gt;Salvia officinalis&lt;/em&gt; hydroalcoholic root extract (800, 1600, and 3200 mg/kg) was administered, and the subjects were monitored for 14 days. Animals were sacrificed on the fifteenth day, and body weight, haematological, and serum hepatic biochemical parameters were assessed and compared to the standard group. &lt;strong&gt;Results:&lt;/strong&gt;Groups treated with &lt;em&gt;Salvia officinalis&lt;/em&gt; showed no mortality or discernible alterations. The findings show that Wistar rats did not experience appreciable harmful effects from administering hydroalcoholic root extract from the &lt;em&gt;Salvia officinalis&lt;/em&gt; plant. &lt;strong&gt;Conclusions:&lt;/strong&gt; The extract can be utilized safely for therapeutic use in pharmaceutical formulations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ranjini HS&lt;sup&gt;1&lt;/sup&gt;, Kadmad Abdul Hameed Mohamed Azar&lt;sup&gt;2&lt;/sup&gt;, S Fayazul Haq&lt;sup&gt;3&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;4*&lt;/sup&gt;, Vinodakumar H R&lt;sup&gt;5&lt;/sup&gt;, Akash&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant professor, Department of Biochemistry, BGSMCH, Nagarur, Bengaluru North, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Pharmacology, Srinivas Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, INDIA .&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Sri Siddhartha Institute of Medical Sciences, Sri Siddhartha Academy of Higher Education, T Begur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Assistant Professor, 6Tutor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Carlos Orlando Garcia-Bustamante</style></author><author><style face="normal" font="default" size="100%">Edwin Cesar Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Jessica Yolanda Huarcaya-Rojas</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Julio Jose Pena-Galindo</style></author><author><style face="normal" font="default" size="100%">Esther Obdulia Franco-Soto</style></author><author><style face="normal" font="default" size="100%">Juana E. Chavez-Flores</style></author><author><style face="normal" font="default" size="100%">Robert Armando Cardenas-Orihuela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Neuroprotective Effects of Chuquiraga spinosa Less. and Baccharis genistelloides (Pers.) Lam. in a Rat Model of Transient Cerebral Ischemia-reperfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cerebral ischemia; neuroprotection; antioxidants; Chuquiraga spinosa Less.; Baccharis genistelloides (Pers.) Lam</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">620-631</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cerebral ischemia, a leading cause of disability and mortality, is strongly related to oxidative stress and inflammation, highlighting the need for neuroprotective antioxidant and cytokinemodulating agents. &lt;strong&gt;Objective: &lt;/strong&gt;To characterize the phytochemical profile and evaluate the antioxidant and neuroprotective effects of hydroalcoholic extracts of&lt;em&gt; Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG), individually and in combination, in a rat model of cerebral ischemia–reperfusion. &lt;strong&gt;Methodology: &lt;/strong&gt;Phytochemical screening and GC-MS were performed with antioxidant assays (ABTS•⁺, DPPH•, FRAP). Neurological deficit was assessed (Bederson scale), while histopathology, oxidative stress markers (MDA, GSH, SOD, CAT, NOx), and cytokines (IL-6, TNF-α, IL-1β) were measured. Groups included Normal (no ischemia), Ischemia (oral placebo), Citicoline 300 mg/kg, ChS 500 mg/kg, BaG 500 mg/kg, and the oral combination ChS 500 + BaG 500 mg/kg, all administered for seven days prior to ischemia induction. &lt;strong&gt;Results: &lt;/strong&gt;ChS had higher total phenolic content than BaG (p = 0.0079). GC-MS identified 23 compounds in ChS and 17 in BaG. The combination displayed greater antioxidant activity than either extract. At 24 h, ChS 500 mg/Kg and the combination reduced severe neurological deficit to 17% (vs. 83% in ischemia). Histopathology revealed less neuronal damage with the combination, comparable to ChS 500 mg/Kg. All treatments decreased MDA levels; the combination also enhanced GSH and CAT and significantly reduced TNF-α and IL-1β. &lt;strong&gt;Conclusion:&lt;/strong&gt; ChS and BaG extracts exert neuroprotective effects against cerebral ischemia. Their combination shows synergistic antioxidant activity against free radicals and enhances the modulation of inflammatory cytokines, supporting a greater neuroprotective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">620</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1*&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Miriam Palomino- Pacheco&lt;sup&gt;2&lt;/sup&gt;, Carlos Orlando García-Bustamante&lt;sup&gt;1&lt;/sup&gt;, Edwin César Cieza-Macedo&lt;sup&gt;1&lt;/sup&gt;, Jessica Yolanda Huarcaya-Rojas&lt;sup&gt;3&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;3&lt;/sup&gt;, Julio José Peña-Galindo&lt;sup&gt;3&lt;/sup&gt;, Esther Obdulia Franco-Soto&lt;sup&gt;3&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;4&lt;/sup&gt;, Robert Armando Cárdenas-Orihuela&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos,Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Científica del Sur, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Academic Program of Pharmacy and Biochemistry, Universidad Norbert Wiener, Lima, PERÚ&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rivan Virlando Suryadinata</style></author><author><style face="normal" font="default" size="100%">Gabriel Tirtawijaya</style></author><author><style face="normal" font="default" size="100%">Sawitri Boengas</style></author><author><style face="normal" font="default" size="100%">Priscilla Keshia Jayasaputri</style></author><author><style face="normal" font="default" size="100%">Henriette Milda Latuputty</style></author><author><style face="normal" font="default" size="100%">Nisa Kirania Dianti Mulyadi</style></author><author><style face="normal" font="default" size="100%">Nawal Fajril Haya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Beltfish (Trichiurus lepturus) Protein Intake and Physical Activity on Muscle Mass Growth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malnutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Muscle Mass</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Intake</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichiurus lepturus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">714-717</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Malnutrition cases have increased every year. One of the causes is insufficient food intake, marked by a decrease in muscle mass. Preventing malnutrition can be done by increasing muscle mass through providing daily protein intake according to needs and engaging in physical activity. The fish species Trichiurus lepturus is a high-protein source from the sea. The protein content in this fish can help promote muscle mass growth. This study aims to determine the effectiveness of protein intake from Trichiurus lepturus combined with physical activity on increasing muscle mass. The research method is experimental, using test animals (Rattus norvegicus) given protein intake and physical activity for 28 days. The animals were divided into six groups: three control groups and three treatment groups receiving different protein levels. Muscle growth was assessed by observing the enlargement of the cruris muscle using HE (hematoxylin and eosin) staining under a 4x microscope magnification. The data obtained were analyzed using ANOVA with an Bonferroni test. The results showed a significant difference between all groups (p=0.000). The treatment groups receiving protein intake and physical activity had larger muscle sizes compared to the control groups (P≤0.05). The conclusion is that protein intake accompanied by physical activity causes changes in muscle mass. Additionally, the amount of protein intake is directly proportional to the increase in muscle size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">714</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rivan Virlando Suryadinata&lt;sup&gt;1*&lt;/sup&gt;, Gabriel Tirtawijaya&lt;sup&gt;2&lt;/sup&gt;, Sawitri Boengas&lt;sup&gt;1&lt;/sup&gt;, Priscilla Keshia Jayasaputri&lt;sup&gt;1&lt;/sup&gt;, Henriette Milda Latuputty&lt;sup&gt;1&lt;/sup&gt;, Nisa Kirania Dianti Mulyadi&lt;sup&gt;1&lt;/sup&gt;, Nawal Fajril Haya&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Suvara Wattanapitayakul</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Citrus aurantifolia Root Ethanolic Extract on Lipogenesis in Palmitate-Induced Lipid Accumulation in HepG2 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid metabolism</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nonalcoholic fatty liver disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">77-83</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Citrus aurantifolia &lt;/em&gt;(lime) is mostly found in tropical and subtropical region. The lime peel and lime juice extracts have antioxidant, antidiabetic and anti-inflammatory effects. However, the pharmacological effects of the lime root remain widely unknown. Thus, the current study investigated the effects of &lt;em&gt;Citrus aurantifolia&lt;/em&gt; root ethanolic extract (CA) on lipogenesis induced by palmitic acid (PA) in HepG2 cells. &lt;strong&gt;Methods: &lt;/strong&gt;The PA-induced lipogenesis in HepG2 cells was used for measuring lipogenic gene expression and lipid accumulation of CA. Phytochemical content was also determined in CA. &lt;strong&gt;Results: &lt;/strong&gt;In PA-treated group showed the state of hepatic lipid accumulation with increased lipogenic gene, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS) and sterol regulatory element binding protein1c (SREBP1c) as compared to the control group. Interestingly, administration of CA (5-10 μg/mL) effectively reduced lipid storage and significantly decreased the expression of these lipogenic gene in PA-treated cells. Notably, CA treatment increased the gene expression of fatty acid oxidation, carnitine palmitoyl transferase 1A (CPT1A) and peroxisome proliferator-activated receptor α (PPARα). Furthermore, this study found that the major bioactive component from CA was nordentatin (coumarin group).&lt;strong&gt; Conclusions:&lt;/strong&gt; The results indicated that the CA treatment might be a useful agent for improving abnormal lipid metabolism in obesity-related nonalcoholic fatty liver disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">77</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Jarinyaporn Naowaboot&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Suvara Wattanapitayakul&lt;sup&gt;3&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;4*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abhinav Dutta</style></author><author><style face="normal" font="default" size="100%">Jyothi Sujan Prasad</style></author><author><style face="normal" font="default" size="100%">Pradyum Anand</style></author><author><style face="normal" font="default" size="100%">Chandrashekar K.S</style></author><author><style face="normal" font="default" size="100%">Venkatesh Kamath B</style></author><author><style face="normal" font="default" size="100%">Vijaya Bhaskar K</style></author><author><style face="normal" font="default" size="100%">Aswatha Ram H.N</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Analytical Evaluation of Herbal Rectal Suppositories Containing Senna Extract for the Management of Constipation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glycerine</style></keyword><keyword><style  face="normal" font="default" size="100%">herbal suppositories</style></keyword><keyword><style  face="normal" font="default" size="100%">senna extract</style></keyword><keyword><style  face="normal" font="default" size="100%">suppositories</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">438-443</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background.&lt;/strong&gt; Senna is a commonly used stimulant laxative that is typically administered orally as a senna extract tablet to treat constipation. This study aimed to formulate rectal suppositories containing senna extract, using glycerin as a base, to achieve site-specific drug delivery and reduce systemic side effects. &lt;strong&gt;Methodology. &lt;/strong&gt;The prepared suppositories were evaluated for various physicochemical and performance parameters, including visual appearance, disintegration time, in vitro dissolution, melting point, weight uniformity, drug content and HPTLC. &lt;strong&gt;Results.&lt;/strong&gt; The suppositories demonstrated satisfactory physical characteristics, with an average weight of 0.9707 g and a drug content of 0.150 ± 2% mg per suppository. The melting point was recorded at 37°C, and the complete dispersion time was 30 minutes. In vitro drug release studies revealed that the drug was fully released within 45 minutes. High-performance thin layer chromatography (HPTLC) was utilized to confirm the presence of active constituents by comparing the sample profile with that of a standard extract. &lt;strong&gt;Conclusion. &lt;/strong&gt;These findings suggest that senna extract suppositories are a promising alternative to oral tablets, providing targeted drug delivery through the rectal route for improved therapeutic outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">438</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abhinav Dutta&lt;sup&gt;1&lt;/sup&gt;, Jyothi Sujan Prasad&lt;sup&gt;1&lt;/sup&gt;, Pradyum Anand&lt;sup&gt;1&lt;/sup&gt;, Chandrashekar K.S.&lt;sup&gt;1&lt;/sup&gt;, Venkatesh Kamath B&lt;sup&gt;2&lt;/sup&gt;, Vijaya Bhaskar K&lt;sup&gt;3&lt;/sup&gt;, Aswatha Ram H.N.&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal-576104, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Baigalmaa Dovchinsuren</style></author><author><style face="normal" font="default" size="100%">Wang Qin Hu</style></author><author><style face="normal" font="default" size="100%">Jambaninj Dambiinyam</style></author><author><style face="normal" font="default" size="100%">Yerkyebulan Mukhtar</style></author><author><style face="normal" font="default" size="100%">Davaadagva Damdinjav</style></author><author><style face="normal" font="default" size="100%">Enkhjargal Dorjbal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation Strategy and Excipient Selection for Tribulus terrestris L. Tablets: A Quality-Based Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tribulus Terrestre’s L.; tablet; excipients; saponins; spectrophotometer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">370-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;To develop and evaluate a tablet formulation containing standardized dry extract of &lt;em&gt;Tribulus terrestris&lt;/em&gt; L.—a plant traditionally used in Mongolian medicine—by focusing on excipient optimization and pharmaceutical quality assessment. &lt;strong&gt;Methods: &lt;/strong&gt;Tablets were manufactured using the wet granulation method, incorporating an extract standardized to 54.45% dioscin. Various excipient ratios were investigated to determine the optimal formulation. Dioscin content was quantified using UV-visible spectrophotometry. &lt;strong&gt;Results: &lt;/strong&gt;The optimized formulation comprised 25% dry extract, 34% lactose, 34% microcrystalline cellulose, 6% PVPP, 0.5% magnesium stearate, 0.5% talc, and 4.5% HPMC. The tablets demonstrated acceptable pharmaceutical characteristics, including an average weight of 0.113 ± 0.001 g, hardness of 0.83 ± 0.23 MPa, friability of 98.17 ± 0.65%, and disintegration time of 7.30 minutes. The dioscin content was 13.50 ± 0.50 mg/g, with an assay recovery of 95.51%. Dissolution exceeded 83% in both media within 45 minutes. The similarity factor (f₂) confirmed equivalent dissolution profiles. &lt;strong&gt;Conclusion: &lt;/strong&gt;The developed&lt;em&gt; T. terrestris&lt;/em&gt; tablet formulation met pharmacopoeial standards and exhibited consistent physical, chemical, and biopharmaceutical performance, supporting its potential as a standardized herbal medicinal product for clinical and commercial application.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">370</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Baigalmaa Dovchinsuren&lt;sup&gt;1&lt;/sup&gt;, Wang Qin Hu&lt;sup&gt;3&lt;/sup&gt;, Jambaninj Dambiinyam&lt;sup&gt;1&lt;/sup&gt;, Yerkyebulan Mukhtar&lt;sup&gt;2&lt;/sup&gt;, Davaadagva Damdinjav&lt;sup&gt;1&lt;/sup&gt;, Enkhjargal Dorjbal&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Mongolian Medicine and Pharmacy, Inner Mongolian University for Nationalities, Tong Liao, CHINA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ledi Yohanis Ruruk Ali</style></author><author><style face="normal" font="default" size="100%">Gemini Alam</style></author><author><style face="normal" font="default" size="100%">Firdaus Hamid</style></author><author><style face="normal" font="default" size="100%">Andi Rofian Sultan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification of Phytochemicals and Antibacterial Activity of South Sulawesi Propolis (Apis mellifera) Using TLC and LC-MS/MSQTOF</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">LC-MS/MS-QTOF</style></keyword><keyword><style  face="normal" font="default" size="100%">propolis (Apis mellifera)</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">352-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Propolis from &lt;em&gt;Apis mellifera&lt;/em&gt; exhibits antimicrobial and antioxidant activities. Despite Indonesia’s rich biodiversity, the phytochemical profile of propolis from South Sulawesi and its antibacterial potential against &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; remain underexplored. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to tentatively identify flavonoid and glycoside compounds in &lt;em&gt;A. mellifera&lt;/em&gt; propolis from South Sulawesi and to evaluate its antibacterial activity. Methods: Propolis samples were collected from Masamba Subdistrict, South Sulawesi, and extracted using 70% ethanol through ultrasonic-assisted extraction. Phytochemical profiling and tentative compound identification were performed using Thin Layer Chromatography (TLC) and LC-MS/MS-QTOF. Antibacterial activity was tested by the disk diffusion method at concentrations of 0.25%, 0.5%, and 0.75%, with ciprofloxacin and distilled water as positive and negative controls. &lt;strong&gt;Results:&lt;/strong&gt; The analysis revealed that flavonoids and glycosides were the main constituents of the extract. These compounds were tentatively identified along with other secondary metabolites, including alkaloids, terpenoids, and phenolic compounds, indicating a complex chemical composition. Antibacterial testing showed mean inhibition zones of 11.23 mm (0.25%), 13.65 mm (0.5%), and 16.50 mm (0.75%), whereas ciprofloxacin and the negative control produced zones of 31.95 mm and 5.70 mm, respectively. ANOVA revealed significant differences among treatments (F = 232.4, p &amp;lt; 0.0001), with the 0.75% extract showing the largest mean inhibition zone. &lt;strong&gt;Conclusions: &lt;/strong&gt;These findings suggest that South Sulawesi propolis contains tentatively identified bioactive flavonoids and glycosides and demonstrates antibacterial activity against &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt;, indicating its potential as a natural antibacterial source for further investigation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">352</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ledi Yohanis Ruruk Ali&lt;sup&gt;1&lt;/sup&gt;, Gemini Alam&lt;sup&gt;2&lt;/sup&gt;, Firdaus Hamid&lt;sup&gt;3&lt;/sup&gt;, Andi Rofian Sultan&lt;sup&gt;3&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;4*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master Program of Biomedical Science, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Samsiana S</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Wahiduddin W</style></author><author><style face="normal" font="default" size="100%">Chatarina Umbul Wahyuni</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Influence of Website-Based Health Information Access Media on Primary Outcomes of Metabolic Syndrome Prevention In ASN Employees</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Booklet</style></keyword><keyword><style  face="normal" font="default" size="100%">Employee</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Literacy</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Website</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">222-230</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background : &lt;/strong&gt;Metabolic syndrome is a condition that can put all people at risk, including workers. It is important to improve health literacy related to the prevention of metabolic syndrome among workers. The association of health literacy on healthy lifestyle modification with a decrease in the prevalence of metabolic syndrome. Objective: The purpose of this study was to analyse the effect of website-based health information access media on risk factors (knowledge, self-efficacy, work stress). &lt;strong&gt;Methods : &lt;/strong&gt;The type of research used is Quasy Experimental design Nonequivalent Control Group design. The sample in this study were 62 employees from 2 government offices engaged in regional finance &amp;amp; assets and the implementation of the water resources network of South Sulawesi province. This study divided two groups, namely the intervention group, which received education through the ‘SAFETY prevent metabolic syndrome’ website and daily journal filling, and the control group, which received education with booklets, with both groups measured and monitored for 2 months. &lt;strong&gt;Results :&lt;/strong&gt; The ‘SAFETY’ websitebased health literacy model intervention was effective in improving knowledge (p=0.000), self-efficacy (p=0.004), and reducing work stress (p=0.047) in government workers, with the significant reduction in work stress demonstrating the benefits of a technology-based approach in managing stress in the work environment. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study was effective in increasing knowledge and self-efficacy and reducing work stress. Future research is recommended to expand the website intervention programme with interactive modules, explore integrated self-efficacy enhancement methods, and develop specific stress management programmes with a multidisciplinary approach.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">222</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Samsiana&lt;sup&gt;1,2*&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;5&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;5&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;6&lt;/sup&gt;, Wahiduddin&lt;sup&gt;4&lt;/sup&gt;, Chatarina Umbul Wahyuni&lt;sup&gt;7&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Student, Faculty of Public Health, Universitas Hasanuddin, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Health administration study program, faculty of sport and health science, Universitas Negeri Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Occupational Safety and Health Section, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Section of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Health Education and Behavioral Sciences, Faculty of Public Health, Universitas Hasanuddin, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rabia Zakaria</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Rahayu Indriasari</style></author><author><style face="normal" font="default" size="100%">Mardiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Muhammad Arsyad</style></author><author><style face="normal" font="default" size="100%">Nurmala Sari</style></author><author><style face="normal" font="default" size="100%">Fatmawati Mohamad</style></author><author><style face="normal" font="default" size="100%">Juli Claudia</style></author><author><style face="normal" font="default" size="100%">Siti Choirul Dwi Astuti</style></author><author><style face="normal" font="default" size="100%">Rahma Dewi Agustini</style></author><author><style face="normal" font="default" size="100%">Magdalena M.Tompunu</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Interpersonal Communication Training as an Effective Strategy to Optimize Multiple Micronutrient Supplementation (MMS) Utilization in Preventing Maternal and Neonatal Deaths</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Interpersonal Communication</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Midwives</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplementation</style></keyword><keyword><style  face="normal" font="default" size="100%">Skills</style></keyword><keyword><style  face="normal" font="default" size="100%">Training</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">399-406</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Maternal mortality remains a global health problem, with approximately 800 deaths every day, mostly due to complications such as bleeding, where severe anemia is a major predisposing factor. Multiple Micronutrient Supplementation (MMS) is now recommended as a substitute for blood supplementation tablets due to its more complete nutritional content. However, utilization of MMS still faces challenges, including low knowledge of pregnant women, negative perceptions of side effects, and misinformation. Education by health workers, especially midwives, is key to overcoming these barriers. Interpersonal communication training is a relevant strategy to improve midwives' ability to deliver information effectively and build positive relationships with pregnant women. Although MMS has begun to be implemented, studies related to the effectiveness of interpersonal communication training in the context of MMS education are still limited in Indonesia. This study aims to fill this gap and strengthen the role of midwives in antenatal care. &lt;strong&gt;Objective:&lt;/strong&gt; To assess the effect of interpersonal communication training on the utilization of multiple micronutrient supplementation on midwives' knowledge and skills. &lt;strong&gt;Methods: &lt;/strong&gt;This study was conducted in September 2024 in Bone Bolango Regency, Gorontalo Province, involving 74 coordinating midwives and village supervisors. The design used was a quasi-experimental one-group pretest-posttest to evaluate the effectiveness of interpersonal communication training on improving midwives' knowledge and skills. Knowledge was measured using a questionnaire, while skills were assessed through a post-training observation checklist. All instruments were tested for validity and reliability. Data analysis included Wilcoxon test to compare pretest and posttest scores, Spearman test to see the relationship between knowledge and skills, and Mann-Whitney test based on midwives' characteristics. Path analysis was conducted within a Structural Equation Modeling (SEM) framework with directly observed variables. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the score before the intervention was 10.80 and after the intervention was 15.23, which means there is a difference in scores between before and after the intervention. The statistical test results showed a p value (0.000) &amp;lt;0.05, which means that there is an effect of interpersonal communication training in the utilization of multiple micronutrient supplements (MMS) on the knowledge and skills of midwives. &lt;strong&gt;Conclusion: &lt;/strong&gt;Interpersonal communication training for midwives is effective in improving midwives' knowledge and skills.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">399</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rabia Zakaria&lt;sup&gt;1,2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;3*&lt;/sup&gt;, Rahayu Indriasari&lt;sup&gt;3&lt;/sup&gt;, Mardiana Ahmad&lt;sup&gt;4&lt;/sup&gt;, Muhammad Arsyad&lt;sup&gt;5&lt;/sup&gt;, Nurmala Sari&lt;sup&gt;6&lt;/sup&gt;, Fatmawati Mohamad&lt;sup&gt;2&lt;/sup&gt;, Juli Claudia&lt;sup&gt;2&lt;/sup&gt;, Siti Choirul Dwi Astuti&lt;sup&gt;2&lt;/sup&gt;, Rahma Dewi Agustini&lt;sup&gt;2&lt;/sup&gt;, Magdalena M.Tompunu&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Gorontalo Health Polytechnic Gorontalo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Midwifery, Graduate School of Hasanuddin University, Makassar, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Promotion and Behavioral Science, Faculty of Public Health, Universitas Hasanuddin. Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Magister of Hospital Administration Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Makassar, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enkhtuul Bayarsaikhan</style></author><author><style face="normal" font="default" size="100%">Turtushikh Damba</style></author><author><style face="normal" font="default" size="100%">Buyanjargal Erdenebat</style></author><author><style face="normal" font="default" size="100%">Norovnyam Ryenchinbyambaa</style></author><author><style face="normal" font="default" size="100%">Otgonsuren Daramzav</style></author><author><style face="normal" font="default" size="100%">Khuvitavilan Battulga</style></author><author><style face="normal" font="default" size="100%">Munkhzul Boldbaatar</style></author><author><style face="normal" font="default" size="100%">Myagmarsuren Badamtsetseg</style></author><author><style face="normal" font="default" size="100%">Enkhjargal Dorjval</style></author><author><style face="normal" font="default" size="100%">Davaadagva Damdinjav</style></author><author><style face="normal" font="default" size="100%">Otgonbaatar Urjin</style></author><author><style face="normal" font="default" size="100%">Maria Halabalaki</style></author><author><style face="normal" font="default" size="100%">Wirginia Kukula-Koch</style></author><author><style face="normal" font="default" size="100%">Daariimaa Khurelbat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Application of the Iceland Poppy (Papaver nudicaule L.) in Traditional Mongolian Medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Nudicaulins</style></keyword><keyword><style  face="normal" font="default" size="100%">Papaver nudicaule L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Protopine</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional Mongolian medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">71-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In recent years, there has been a considerable focus on the utilization of natural medicinal substances, including plant-based medicines and formulations. While traditional medicine has been utilizing various medicinal plants to treat a wide range of diseases, there are still many medicinal plants and substances that have not been thoroughly studied at the scientific level. One such plant is the Iceland poppy (&lt;em&gt;Papaver nudicaule L.&lt;/em&gt;) from the Papaveraceae family. Globally, the Papaveraceae family comprises 44 genera and 760 species of which 32 species, representing 7 genera, are identified within Mongolia. The Iceland poppy (&lt;em&gt;Papaver nudicaule L.&lt;/em&gt;) is extensively distributed throughout Mongolia, with all parts of the plant, including its fruit and flowers. In addition, it has been traditionally employed in Mongolian medicine to treat a variety of ailments. However, systematic research on the practical applications and studies of the status of the local Iceland poppy in both modern and traditional Mongolian medicine remains poorly reported. Therefore, we aim to conduct a comprehensive and comparative study of the Iceland poppy (Papaver nudicaule L.) and its application in the Traditional Mongolian medicinal literature and internationally published studies. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In this study, data was collected from a comprehensive review of the international and Traditional Mongolian medicine literature to understand the medicinal application of the Iceland poppy. Additionally, current study results were analyzed to assess its practical applications and efficacy in modern medicinal contexts. &lt;strong&gt;Results:&lt;/strong&gt; &quot;In a variant of Mongolian medicinal prescriptions, the Iceland poppy (Papaver nudicaule L.) is combined with the herb “Govo jad-5” Mongolian traditional prescription for treating surgical wounds, torn blood vessels, and both old and new wounds. Furthermore, the book 'Methods and Prescriptions for Using Medicinal Plants in Traditional Mongolian Medicine reports that Iceland poppy is part of a mixture of four types of poppies used to treat conditions such as diarrhea, intestinal inflammation, and dysentery, by boiling and administering the concoction. A study by Otgonpurev Sukhbaatar et al., (2018) determined that the optimal conditions for callus and suspension biomass production of &lt;em&gt;Papaver nudicaule L.&lt;/em&gt; are 1 mg/L naphthalene acetic acid and 0.5 mg/L benzyl adenine in MS media. Additionally, Gerelt-Od Yadamsuren et al., reported that the alkaloids 8,14-dihydroamurin, 8,14-dihydroflavinantin, and flavinantin from Papaver nudicaule L. exhibit significant antiviral activity against human rhinovirus-14. &lt;strong&gt;Conclusion: &lt;/strong&gt;Iceland poppy (&lt;em&gt;Papaver nudicaule L.&lt;/em&gt;) has been used in traditional Mongolian medical practice for a long time. it has been historically widely used in Mongolian traditional medicine to treat wounds under the name of “wound healer”. As reported by the scientific literature, the primary uses of these plants include inhibiting acetylcholinesterase enzyme, anti-cancer effects, as well as antioxidant and anti-inflammatory properties. Furthermore, regarding its chemical composition, researchers have conducted studies that confirm the presence of alkaloids in this plant, specifically isoquinoline alkaloids. These compounds are known for their diverse biological activities and potential therapeutic effects, which may contribute to the plant's traditional medicinal uses. In summary, the Iceland poppy (&lt;em&gt;Papaver nudicaule L.&lt;/em&gt;) has been utilized in traditional medicine for treating a variety of illnesses; however, it suggests that more comprehensive research is necessary to scientifically substantiate these applications.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enkhtuul Bayarsaikhan&lt;sup&gt;1&lt;/sup&gt;, Turtushikh Damba&lt;sup&gt;1&lt;/sup&gt;, Buyanjargal Erdenebat&lt;sup&gt;1&lt;/sup&gt;, Norovnyam Ryenchinbyambaa&lt;sup&gt;1&lt;/sup&gt;, Otgonsuren Daramzav&lt;sup&gt;2&lt;/sup&gt;, Khuvitavilan Battulga&lt;sup&gt;1&lt;/sup&gt;, Munkhzul Boldbaatar&lt;sup&gt;1&lt;/sup&gt;, Myagmarsuren Badamtsetseg&lt;sup&gt;3&lt;/sup&gt;, Enkhjargal Dorjval&lt;sup&gt;1&lt;/sup&gt;, Davaadagva Damdinjav&lt;sup&gt;2&lt;/sup&gt;, Otgonbaatar Urjin&lt;sup&gt;1&lt;/sup&gt;, Maria Halabalaki&lt;sup&gt;5&lt;/sup&gt;, Wirginia Kukula-Koch&lt;sup&gt;4&lt;/sup&gt;, Daariimaa Khurelbat&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Technology, School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical pharmacy and management, School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, POLAND. 5Department of Pharmacy, National and Kapodistrian University of Athens, Greece&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dinar S. C. Wahyuni</style></author><author><style face="normal" font="default" size="100%">Raissa. K. Putri</style></author><author><style face="normal" font="default" size="100%">Anik Arniyanti</style></author><author><style face="normal" font="default" size="100%">Sasha H. Audita</style></author><author><style face="normal" font="default" size="100%">Syaiful Choiri</style></author><author><style face="normal" font="default" size="100%">Saptono Hadi</style></author><author><style face="normal" font="default" size="100%">Rita Rakhmawati</style></author><author><style face="normal" font="default" size="100%">Estu R. Nugraheni</style></author><author><style face="normal" font="default" size="100%">Soerya D. Marliyana</style></author><author><style face="normal" font="default" size="100%">Yudi Rinanto</style></author><author><style face="normal" font="default" size="100%">Ari Satia Nugraha</style></author><author><style face="normal" font="default" size="100%">Ahmad Ainurofiq</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Metabolomic Study on Indonesian Green Tea (Camellia Sinensis L.) Cultivation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tea leaves; Camellia sinensis; metabolite profiling; 1H-NMR; Indonesia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">331-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Indonesia has been one of the largest tea producers in the world with one of the reputable plantations in Ngargoyoso region, Java Island in which the plantation specified in five green teas variants, TRI 2024, TRI 2025, Gambong, Kiara and Chinruan. Despite their premium quality, there were limited metabolites information related to varieties, altitude, and plucking position existed in Ngargoyoso. &lt;strong&gt;Objective: &lt;/strong&gt;this research aimed to investigate metabolite profiling affected by varieties, plucking positions and altitudes in the tea plantation grown in Ngargoyoso, Indonesia. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Green tea (&lt;em&gt;Camellia sinensis&lt;/em&gt; L.) grown in the plantation are five varieties TRI 2025, Gambong, TRI2024, Kiara and Chinruan in Ngargoyoso. &lt;strong&gt;Results:&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;H NMR metabolomics protocol successfully identified TRI 2025 variety to have higher levels of theanine, catechins and caffeine than other varieties. The young leaves plucking position showed a higher level of catechin, EGCG, caffeine, theobromine, and L-glutamine than the older ones. While green tea at 1159 masl contains a higher level of theanine, L-glutamin, α-glucose, β-glucose, quinic acid, and succinic acid than those at 899 masl. This makes the TRI 2025 variety at the young position can be recommended to be the best quality in taste and benefits. &lt;strong&gt;Conclusion: &lt;/strong&gt;Present study might suggest the tea quality based on metabolites profiling both for taste and benefits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">331</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dinar S. C. Wahyuni&lt;sup&gt;1*&lt;/sup&gt;, Raissa. K. Putri&lt;sup&gt;1&lt;/sup&gt;, Anik Arniyanti&lt;sup&gt;1&lt;/sup&gt;, Sasha H. Audita&lt;sup&gt;1&lt;/sup&gt;, Syaiful Choiri&lt;sup&gt;1&lt;/sup&gt;, Saptono Hadi&lt;sup&gt;1&lt;/sup&gt;, Rita Rakhmawati&lt;sup&gt;1&lt;/sup&gt;, Estu R. Nugraheni&lt;sup&gt;1&lt;/sup&gt;, Soerya D. Marliyana&lt;sup&gt;2&lt;/sup&gt;, Yudi Rinanto&lt;sup&gt;3&lt;/sup&gt;, Ari Satia Nugraha&lt;sup&gt;4&lt;/sup&gt; and Ahmad Ainurofiq&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Active Pharmaceutical Discovery and Development Research Group, Department of Pharmacy, Universitas Sebelas Maret Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Biology Education Program, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jl. Kalimantan I/2, Jember, 68121, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elmi Sariani Hasibuan</style></author><author><style face="normal" font="default" size="100%">Ayus Diningsih</style></author><author><style face="normal" font="default" size="100%">Cory Linda Futri Harahap</style></author><author><style face="normal" font="default" size="100%">Anto J. Hadi</style></author><author><style face="normal" font="default" size="100%">Hafni Nur Insan</style></author><author><style face="normal" font="default" size="100%">Rini Fitriani Dongoran</style></author><author><style face="normal" font="default" size="100%">Haslinah Ahmad</style></author><author><style face="normal" font="default" size="100%">Hapiz Arlanda Sani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microencapsulation of Paracetamol with Polycaprolacone Coating</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Microencapsulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycaprolactone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">89-94</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Paracetamol is widely used as a medicine for fever and pain. Paracetamol has a normal half-life in the blood of 2 hours. If paracetamol is consumed frequently it will cause stomach irritation. This research aims to cover the unpleasant taste of paracetamol by microencapsulating using a coating and changing the release of paracetamol microcapsules. In this study, the coating material used was polycaprolactone because polycaprolactone is a biodegradable coating material. The amount of coating used in this study was 1.5g, 3g and 4.5g. Paracetamol microencapsulation was carried out in evaluation tests, namely organoleptic examination and particle size. Then a characterization test was carried out, namely the surface morphology test of the paracetamol microencapsulation using the Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR) method and the dissolution test. The research results showed that the concentration obtained by Formula 1 was 95.66%, Formula 2 was 97.17 and F3 was 98.81. The dissolution test results showed that the largest dissolution percentage of microcapsules in formula 1 was 97.85% at 50 minutes, formula 2 was 98.13 at 55 minutes and formula 3 was 98.91% at 60 minutes. Microencapsulation of paracetamol with polycaprolactone can cover the bitter taste and changing the release of paracetamol microcapsules into sustained release preparations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elmi Sariani Hasibuan&lt;sup&gt;1*&lt;/sup&gt;, Ayus Diningsih&lt;sup&gt;1&lt;/sup&gt;, Cory Linda Futri Harahap&lt;sup&gt;1&lt;/sup&gt;, Anto J. Hadi&lt;sup&gt;2&lt;/sup&gt;, Hafni Nur Insan&lt;sup&gt;2&lt;/sup&gt;, Rini Fitriani Dongoran&lt;sup&gt;2&lt;/sup&gt;, Haslinah Ahmad&lt;sup&gt;2&lt;/sup&gt;, Hapiz Arlanda Sani&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departemen Farmasi, Fakultas Kesehatan, Universitas Aufa Royhan, Padangsidimpuan, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departemen Kesehatan Masyarakat, Fakultas Kesehatan, Universitas Aufa Royhan, Padangsidimpuan, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ace Baehaki</style></author><author><style face="normal" font="default" size="100%">Sabrina Rahmadania</style></author><author><style face="normal" font="default" size="100%">Herpandi H</style></author><author><style face="normal" font="default" size="100%">Muhammad Hendri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Peptide Production from Snakehead Fish (Channa striata) extract with the addition of Bay leaf (Syzygium polyanthum) and Basil leaf (Ocimum basilicum)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basil leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Bay leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Degree of Hydrolysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Peptides</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein Content</style></keyword><keyword><style  face="normal" font="default" size="100%">Snakehead fish</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">542-544</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to determine the effect of adding bay leaves (&lt;em&gt;Syzygium polyanthum&lt;/em&gt;) and basil leaves (&lt;em&gt;Ocimum basilicum&lt;/em&gt;) on the peptide extract of snakehead fish (&lt;em&gt;Channa Striata&lt;/em&gt;). The research utilized a Randomized Complete Block Design (RCBD) with 4 treatment factors and 3 replications. Treatments involved different leaf additions during the preparation of the fish peptide extract: control (A0), bay leaves (A1), basil leaves (A2), and both bay and basil leaves (A3). Parameters observed were protein content analysis, degree of hydrolysis, and protein profile using SDS-PAGE. The results of protein content analysis showed no significant effect on protein content, with averages of 6.25% for treatment A0, 6.09% for A1, 10.83% for A2, and 9.80% for A3. The degree of hydrolysis results indicated highly significant differences, confirmed by Tukey's Honestly Significant Difference (HSD) test at a 5% significance level: 22.21% for A0, 41.82% for A1, 52.76% for A2, and 43.66% for A3. This demonstrates very significant variation among treatments. The protein profile analysis of the snakehead fish peptide extract showed that treatments involving the addition of bay leaves and basil leaves affected the molecular weight of proteins in the range of 10-140 kDa and the number of protein bands produced.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ace Baehaki&lt;sup&gt;1*&lt;/sup&gt;, Sabrina Rahmadania&lt;sup&gt;1&lt;/sup&gt;, Herpandi&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hendri&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Jl Palembang-Prabumulih Km 32, Indralaya Ogan Ilir, South Sumatera, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Study Program of Marine, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Jl Palembang-Prabumulih Km 32, Indralaya Ogan Ilir, South Sumatera, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mandla Hlongwane</style></author><author><style face="normal" font="default" size="100%">Siphamandla Lamula</style></author><author><style face="normal" font="default" size="100%">Lisa Buwa-Komoreng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antimicrobial Activity of Medicinal Plants Commonly Used in the Treatment of Tuberculosis in the Eastern Free State, South Africa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dicoma anomala</style></keyword><keyword><style  face="normal" font="default" size="100%">Drimia depressa</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucomis autumnalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hermannia depressa</style></keyword><keyword><style  face="normal" font="default" size="100%">Lotononis lanceolata</style></keyword><keyword><style  face="normal" font="default" size="100%">Senecio harveianus</style></keyword><keyword><style  face="normal" font="default" size="100%">Thesium angulosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Xysmalobium undulatum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">155-163</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tuberculosis (TB), an airborne infectious disease that mainly infects the lungs, caused by&lt;em&gt; Mycobacterium tuberculosis.&lt;/em&gt; South Africa is one of the countries with the highest TB and multi-drugresistant TB burden.&lt;strong&gt; Objective: &lt;/strong&gt;This study aimed at screening eight medicinal plants that are frequently used by herbalists and traditional healers of the eastern Free State for the treatment of TB. &lt;strong&gt;Methods:&lt;/strong&gt; Thirty-two plant extracts were screened for the presence of phytochemicals, antibacterial, antifungal and antimycobacterial activities using standard methods. &lt;strong&gt;Results:&lt;/strong&gt; Extracts prepared from &lt;em&gt;Hermannia depressa&lt;/em&gt; and &lt;em&gt;Senecio harveianus &lt;/em&gt;displayed the best antibacterial activity against all test microorganisms ranging between 0.098 and 0.781 mg/ml while &lt;em&gt;Drimia depressa&lt;/em&gt; and &lt;em&gt;Lotononis lanceolata &lt;/em&gt;extracts displayed the best antifungal activity between 0.049 and 0.781 mg/ml. The good antimycobacterial activity was observed with organic extracts prepared from&lt;em&gt; Dicoma anomala,&lt;/em&gt; &lt;em&gt;H. depressa, L. lanceolata &lt;/em&gt;and &lt;em&gt;S. harveianus &lt;/em&gt;between 0.195 and 0.781 mg/ml. &lt;strong&gt;Discussion:&lt;/strong&gt; All plants displayed the presence of tannins and saponins and the absence of alkaloids, anthraquinones and steroids. Plants under this study demonstrated significant antibacterial, antifungal and antimycobacterial activities, with extracts prepared from &lt;em&gt;H. depressa &lt;/em&gt;and &lt;em&gt;S. harveianus &lt;/em&gt;displaying the best activity against all the test microorganisms with MIC values ranging between 0.098 and 0.781 mg/ml, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The selected medicinal plants that are used in the treatment of TB and related respiratory ailments in the eastern Free State revealed the presence of phytochemicals and significant antimicrobial activities, which explain and justify their frequent use by traditional healers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mandla Hlongwane&lt;sup&gt;1&lt;/sup&gt;, Siphamandla Lamula&lt;sup&gt;2&lt;/sup&gt;, Lisa Buwa-Komoreng&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Directorate, Mangosuthu University of Technology, Durban, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Botany Department, Faculty of Science and Agriculture, University of Fort Hare, Alice, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitrianty Sutadi Lanyumba</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Darmawansyah D</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Wahiduddin W</style></author><author><style face="normal" font="default" size="100%">Faizal Fahmi</style></author><author><style face="normal" font="default" size="100%">Anang S Otoluwa</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preconception Posyandu Performance Assessment Instrument with Europan Foundation Quality Management (EFQM) Method: Indicators, Validity and Reliability</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">EFQM</style></keyword><keyword><style  face="normal" font="default" size="100%">Instrument</style></keyword><keyword><style  face="normal" font="default" size="100%">Performance Appraisal</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception Health Post</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">40-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Preconception Posyandu is one of the preconception women's health services created to help reduce MMR, IMR and stunting prevalence in Banggai District. This study aims to create a performance assessment instrument for the Preconception Posyandu so that it can maintain the existence of the service. The development of performance assessment indicators through Focus Discussion Group (FGD) activities using the Europan Foundation Quality Management (EFQM) method consists of using 9 variables. We involved 30 village midwives and 30 preconception women at three health centers within Luwuk City to test the performance assessment instrument. Internal reliability was assessed with Cronbach's alpha and criterion validity. The performance appraisal instrument using the EFQM method obtained development results, namely from 52 indicator questions made into 92 questions, then after testing the validity of the instrument, 81 questions were declared valid and 11 questions were invalid. The results of Cronbach's alpha value, there are 5 variables with strong reliability (alpha&amp;gt; 0.80), namely leadership variables, strategic policies, staff management and partnerships and resources, while there is 1 variable with perfect reliability (alpha&amp;gt; 0.90), namely process variables, and 3 variables with sufficient reliability (alpha &amp;gt; 0.70), namely performance outcome variables, customer satisfaction and impact on society. The questions generated from the development of indicators can be used to measure performance. The service of the Preconception Posyandu Program that has been running so far, this is evidenced by the average value of the reliability test which is 0.83, which means strong reliability.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">40</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitrianty Sutadi Lanyumba&lt;sup&gt;1,10*&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;2&lt;/sup&gt;, Darmawansyah&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;5&lt;/sup&gt;, Wahiduddin&lt;sup&gt;6&lt;/sup&gt;, Faizal Fahmi&lt;sup&gt;8&lt;/sup&gt;, Anang S Otoluwa&lt;sup&gt;9,10&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Administration and Health Policy, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nutritionist, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;BKKBN Department, South Sulawesi Province, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Health Department, Gorontalo Province, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Faculty of Public Health, Tompotika University Luwuk Banggai, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hesti Riasari</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Siti Uswatun Hasanah</style></author><author><style face="normal" font="default" size="100%">Mia Aulia</style></author><author><style face="normal" font="default" size="100%">Khania Zavella</style></author><author><style face="normal" font="default" size="100%">Nurul Padilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantification of Phenolics, Flavonoids, and In Vitro Antioxidant Activity in Rosella and Breadfruit Leaf Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantification of Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">688-698</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is a country rich in biodiversity, with numerous plant species traditionally used in medicine. One such plant is breadfruit (&lt;em&gt;Artocarpus altilis&lt;/em&gt;), whose leaves contain bioactive compounds such as flavonoids, saponins, tannins, quercetin, artocarpanone, and artoindonesianin. Another plant with high medicinal value is roselle (&lt;em&gt;Hibiscus sabdariffa L.&lt;/em&gt;), a tropical plant from the Malvaceae family known for its rich phenolic content. Both plants are widely found across Indonesia and have potential as natural antioxidants. In this study, the dry extracts were prepared using the decoction method followed by spray drying. Phytochemical screening, total phenolic and flavonoid content analysis, and antioxidant activity tests were performed using standard in vitro methods. The DE2C extract (a combination of breadfruit leaves and roselle flowers) exhibited high total phenol content at 0.953 ± 0.005 g GAE/100 g and flavonoid content at 136.97 ± 5.050 μg QE/100 g. Meanwhile, the DE3C extract showed an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 540.55 ppm in the DPPH assay. Pearson correlation analysis showed a strong positive correlation between total phenolic content and antioxidant activity (R = 0.956, p &amp;lt; 0.05), while flavonoids also showed a moderate correlation (R = 0.502, p &amp;lt; 0.05). These results confirm that phenolic compounds play a key role in the antioxidant potential of the extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hesti Riasari&lt;sup&gt;1,*&lt;/sup&gt;, Sani Nurlaela Fitriansyah&lt;sup&gt;1&lt;/sup&gt;, Siti Uswatun Hasanah&lt;sup&gt;1&lt;/sup&gt;, Mia Aulia&lt;sup&gt;1&lt;/sup&gt;, Khania Zavella&lt;sup&gt;1&lt;/sup&gt;, Nurul Padilah&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Pharmaceutical Biology, Indonesia School of Pharmacy, Bandung. INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prajna R H</style></author><author><style face="normal" font="default" size="100%">Shivananda Nayak</style></author><author><style face="normal" font="default" size="100%">Priya V</style></author><author><style face="normal" font="default" size="100%">Shruthi Rai P</style></author><author><style face="normal" font="default" size="100%">Shivaraja shankara Y M</style></author><author><style face="normal" font="default" size="100%">Prashanthkumar Goudappala</style></author><author><style face="normal" font="default" size="100%">Dinesh PV</style></author><author><style face="normal" font="default" size="100%">Namratha KG</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The role of TNF-Alpha, IL-6, Adiponectin, and Leptin in Inflammation and Metabolic Dysregulation in Type 2 Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adiponectin</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic Dysregulation</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-Alpha</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">699-702</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Type 2 Diabetes Mellitus (T2DM) is characterized by chronic inflammation and metabolic dysregulation. The present study investigates the role of inflammatory markers, including TNF-alpha and IL-6, and metabolic hormones such as adiponectin and leptin, in individuals with T2DM. &lt;strong&gt;Methods:&lt;/strong&gt; A total of 147 participants diagnosed with T2DM were included in the study. Clinical and biochemical parameters, including fasting blood sugar (FBS), glycated hemoglobin (HbA1C), adiponectin, leptin, TNF-alpha, and IL-6, were measured. Descriptive statistics and correlation analysis were performed to determine associations between inflammatory markers and metabolic dysregulation.&lt;strong&gt; Results: &lt;/strong&gt;The mean age of participants was &lt;strong&gt;42.63 ± 6.38 &lt;/strong&gt;years, and the average BMI was &lt;strong&gt;28.38 ± 2.25 kg/m²&lt;/strong&gt;. FBS and HbA1C levels were &lt;strong&gt;175.72 ± 61.61 mg/dL&lt;/strong&gt; and &lt;strong&gt;7.26 ± 0.94%,&lt;/strong&gt; respectively. The mean adiponectin and leptin levels were &lt;strong&gt;4.71 ± 1.75 μg/mL&lt;/strong&gt; and &lt;strong&gt;20.58 ± 5.19 ng/mL&lt;/strong&gt;, respectively. TNF-alpha and IL-6 levels averaged &lt;strong&gt;132.00 ± 9.45 pg/mL&lt;/strong&gt; and &lt;strong&gt;33.52 ± 14.55 pg/mL&lt;/strong&gt;, respectively. Correlation analysis indicated an inverse relationship between adiponectin and BMI, while leptin was positively correlated with BMI and insulin levels. Elevated TNFalpha and IL-6 levels were associated with increased HbA1C and fasting blood glucose. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study highlights the significant role of inflammatory markers in metabolic dysregulation among T2DM patients. Elevated TNF-alpha and IL-6 levels reinforce the link between chronic inflammation and impaired glucose metabolism. These findings underscore the need for anti-inflammatory strategies in diabetes management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">699</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prajna R H&lt;sup&gt;1,2&lt;/sup&gt;, Shivananda Nayak&lt;sup&gt;3&lt;/sup&gt;, Priya V&lt;sup&gt;4*&lt;/sup&gt;, Shruthi Rai P&lt;sup&gt;5&lt;/sup&gt;, Shivaraja shankara Y M&lt;sup&gt;6&lt;/sup&gt;, Prashanthkumar Goudappala&lt;sup&gt;7&lt;/sup&gt;, Dinesh PV&lt;sup&gt;8&lt;/sup&gt;, Namratha KG&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research scholar, SaveethaResearch Center, Saveetha Institute of Medical and Technical Sciences(SIMATS), Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Biochemistry, Subbaiah Institute of Medical Science, Shivamogga, INDIA,577222&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Center of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University Chennai, INDIA,600077&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Biochemistry, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Associate Professor, Department of Biochemistry, Sri Siddhartha Medical College, Sri Siddhartha Academy of Higher Education, Tumkur, INDIA ,572107&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Professor, Department of Community medicine, KVG Medical College and Hospital, Sullia, INDIA, 574327&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor, Department of Microbiology, KVG Medical College and Hospital,Sullia , INDIA, 574327.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bassam A. Hazae</style></author><author><style face="normal" font="default" size="100%">Yetti Hernaningsih</style></author><author><style face="normal" font="default" size="100%">Puspa Wardhani</style></author><author><style face="normal" font="default" size="100%">Fatima Albadwi</style></author><author><style face="normal" font="default" size="100%">Nastasya Nunki</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Abnormalities in Hemostatic Parameters Related to Hemodialysis in End-stage Kidney Pathology: A Narrative Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Coagulation</style></keyword><keyword><style  face="normal" font="default" size="100%">End-stage Kidney Disease (ESKD)</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemodialysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemostasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1223-1230</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Chronic kidney disease (CKD) is a progressively prevalent global health issue. During the initial phases of the condition, CKD is commonly linked to a tendency for excessive blood clotting. While in the end-stage of disease, patients undergoing hemodialysis have a multitude of hemostatic abnormalities. These include prolonged bleeding time, altered platelet count, prolonged PT and aPTT, elevated FDPs and D-dimer, dysregulated vWF activity, and abnormal thrombin generation. These changes result from a combination of uremic toxicity, endothelial dysfunction, inflammatory states, and the effects of the hemodialysis procedure itself. Understanding these mechanisms is crucial for managing and mitigating the bleeding and thrombotic risks in this patient population. This review aims to systematically investigate the effects of hemodialysis on key hemostasis parameters in CKD patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bassam A. Hazae&lt;sup&gt;1&lt;/sup&gt;, Yetti Hernaningsih&lt;sup&gt;2,3,4*&lt;/sup&gt;, Puspa Wardhani&lt;sup&gt;2,3,4,5&lt;/sup&gt;, Fatima Albadwi&lt;sup&gt;6&lt;/sup&gt;, Nastasya Nunki&lt;sup&gt;1,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory Medicine Study Interest, Master Program of Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;²Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;⁴Postgraduate School of Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Institute of Tropical Disease, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Master student, Biotechnology and Bioengineering, East China University of Science and Technology, Shanghai, CHINA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Laboratory Technology, Faculty of Health, Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Evawati</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Sudirman Natsir</style></author><author><style face="normal" font="default" size="100%">Razak Thaha</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Lucy Widiasari</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of the Giving of Mp-Asi Through Food Based on Majene's Local Wisdom for Stunting Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Food based Local</style></keyword><keyword><style  face="normal" font="default" size="100%">MP-ASI</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting Prevention</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Majene Society own tradition and knowledge typical in selecting, processing, and consuming food. Use food local can maintain diversity food and culture local. Food local has proven effective for growth baby optimally. &lt;strong&gt;Goals:&lt;/strong&gt; With do comprehensive analysis to provision of MP-ASI through foodbased wisdom local Majene, expected can an effective and sustainable stunting prevention program was developed.&lt;strong&gt; Method: &lt;/strong&gt;Method research used is study qualitative with design phenomenology. Informant in study This are 103 Baduta mothers who are exclusively breastfed, and live in rural districts Pamboang and District Tameroddo. Data analyzed use content analysis through N-Vivo 12 app. &lt;strong&gt;Results:&lt;/strong&gt; Food tree chief in Tameroddo is rice red Because rice red become plant lots of fields found and easy grows in mountainous areas. Meanwhile in the Coastal Region Pamboang Still consistent with rice white or yams. Typical vegetables is leaf moringa, Langurru ', and Lallere '. Government Regency Majene push planting leaf moringa in each home easy get and help in increase continuity food, savings cost, and independence food in Majene. Besides That, leaf moringa of course known known as &quot; tree magic &quot; because mark high nutrition. Majene Society own access and consumption vegetables langngurru ' and lallere ' are just that found in the area mountains Tameroddo. Usually leaf This used as plant medicine, but in this area made as processed vegetables with add mango sour. Side dish typical Majene known with called &quot; Baupapi &quot;. Habit consumption child given Eat with Fish sauce is considered Already enough , even often this fish sauce considered as replacement vegetables , though very easy found various the main fish species in the coastal area Pamboang . Known Pineapple in local language Majene as “Pandeng” is easiest fruit found Because grow with flourish in the yards House citizen. Findings food local the has content test nutrition and recipe test so that can used as the proper MP-ASI menu for given to baby for optimal growth. &lt;strong&gt;Conclusions and Suggestions:&lt;/strong&gt; Important For ensure that kids get too consumption of fish or other protein sources as well as nutrition from vegetables and sources food other. Order child get appropriate nutrition through provision of adequate MP-ASI. Recommended to nanny , power health and government regency Majene to encourage provision of local MP-ASI with still notice mark appropriate nutrition , MP -ASI module as research output This can used as guidelines Proper provision of MP-ASI .&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Evawati&lt;sup&gt;1,*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;2&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;2&lt;/sup&gt;, Sudirman Natsir&lt;sup&gt;3&lt;/sup&gt;, Razak Thaha&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Lucy Widiasari&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Student, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Nutrition Department, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Health Promotion, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Epidemiology, Public Health Faculty, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aktsar Roskiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Abd. Malik</style></author><author><style face="normal" font="default" size="100%">Selpida Handayani</style></author><author><style face="normal" font="default" size="100%">Iskandar Zulkarnain</style></author><author><style face="normal" font="default" size="100%">Amliati A</style></author><author><style face="normal" font="default" size="100%">Nur Lailatulqadri</style></author><author><style face="normal" font="default" size="100%">Mardatilla Mamas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of Senna (Senna alexandrina MILL.) Leaf Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Senna leaf; Maceration; Phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1355-1358</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Senna leaf plant (Senna alexandrina Mill.) is empirically effective in treating several diseases. Senna leaves contain saponins, alkaloids, glycosides, flavonoids, phenols, sesquiterpenes, tannins, and phytosterols. This study aims to assess Senna leaf extract's antioxidant activity, flavonoid, and phenolic content (Senna alexandrina Mill.) with various extraction methods and solvent variations.&amp;nbsp;&lt;strong&gt;Read more . . .&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1355</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aktsar Roskiana Ahmad&lt;sup&gt;1,2*&lt;/sup&gt;, Abd. Malik&lt;sup&gt;1,2&lt;/sup&gt;, Selpida Handayani&lt;sup&gt;1&lt;/sup&gt;, Iskandar Zulkarnain&lt;sup&gt;1&lt;/sup&gt;, Amliati&lt;sup&gt;1&lt;/sup&gt;, Nur Lailatulqadri&lt;sup&gt;1&lt;/sup&gt;, Mardatilla Mamas&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Magister of Pharmacy, Universitas Muslim Indonesia, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ni Putu Ayu Reza Dhiyantari</style></author><author><style face="normal" font="default" size="100%">Dicky Hermawan</style></author><author><style face="normal" font="default" size="100%">Nurwasis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Apoptosis of The Lens Epithelial Cells After Ultraviolet-B Exposure as a Proposed Pathogenesis of Senile Cataract: Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">989-992</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cataract shares a major burden causing half of the world's visual impairment and blindness. Ultraviolet light exposure has been associated with a higher incidence of cataracts. UV irradiation causes damage to the ocular tissue through protein crosslinking, enzyme dysfunction, ion pump inhibition, genetic mutation, and cell membrane disruption. Irreversible damage causes apoptosis to the lens epithelial cells, which is the main motor of lens homeostasis. Disturbance to the lens homeostasis will result in the loss of lens transparency and the development of cataracts. Understanding the pathophysiology of UV-induced cataract may bring to better approach to slower progression of the aging of the lens and formation of cataractous lenses.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">989</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ni Putu Ayu Reza Dhiyantari, Dicky Hermawan*, Nurwasis&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramli Ramli</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cadre Assistance in Improving the Nutritional Status of Two Years Baby: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baduta Nutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Cadres</style></keyword><keyword><style  face="normal" font="default" size="100%">Mentoring</style></keyword><keyword><style  face="normal" font="default" size="100%">Two years baby.</style></keyword><keyword><style  face="normal" font="default" size="100%">underweight</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">960-965</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The Health Law mandates that efforts to improve community nutrition aim to improve the nutritional quality of individuals and society. Indonesia is still a country with a fairly high category of nutritional problems. Very underweight badgers were 1.2% and underweight badgers were 5.2%. Overcoming nutritional problems must involve various parties in society, one of the community parties who plays an important role in overcoming nutritional problems for toddlers is health cadres in the village, especially nutritional problems for toddlers. &lt;strong&gt;Objective&lt;/strong&gt;: to identify and explain scientific evidence regarding Mentoring Efforts by Cadres to improve Nutrition for Baduta and strengthen the theoretical basis that can support solving the problem being researched. &lt;strong&gt;Method:&lt;/strong&gt; Using online journal databases that can be accessed in PDF form, namely, Pubmed, Elsevier/Scopus, Crossref and Google Scholar. Other sources such as textbooks, national health reports, and dissertations. The search included studies published in the last 10 years (2012–2022). Using keywords (Kader, Nutrition Baduta, Posyandu Cadre, Cadre, Health Workers, Nutrition Health Workers). Appropriate articles were then entered into Mendeley. &lt;strong&gt;Results:&lt;/strong&gt; &lt;strong&gt;Conclusion: &lt;/strong&gt;Assistance to cadres can increase cadres' knowledge and skills in improving nutrition for children, especially toddlers and toddlers. Mentoring and empowering cadres is carried out using various methods such as counseling, training, using various tools and media.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">960</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ramli Ramli&lt;sup&gt;1,2*&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;1&lt;/sup&gt;, Veni Hadju&lt;sup&gt;1&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Public Health,&amp;nbsp;Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health&amp;nbsp;Tompotika Luwuk University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laila Tsaqilah</style></author><author><style face="normal" font="default" size="100%">Annisa Febrieza Zulkarnaen</style></author><author><style face="normal" font="default" size="100%">Hartati Purbo Dharmadji</style></author><author><style face="normal" font="default" size="100%">Risa Miliawati Nurul Hidayah</style></author><author><style face="normal" font="default" size="100%">Erda Avriyanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Case Report: High Dose Systemic Corticosteroids as the Therapy for Severe Case Impetigo Herpetiformis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Impetigo herpetiformis</style></keyword><keyword><style  face="normal" font="default" size="100%">Prednisolone</style></keyword><keyword><style  face="normal" font="default" size="100%">Pustular Psoriasis of Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">498-502</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Impetigo herpetiformis (IH) is a rare but life-threatening dermatosis of pregnancy. Early recognition and treatment of IH is important because it may cause maternal and fetal morbidity and mortality. Systemic corticosteroids remain the mainstay of treatment for IH and are considered safe for pregnancy. The purpose of this study was to present successful high-dose corticosteroids as a therapy for severe cases of IH. &lt;strong&gt;Case:&lt;/strong&gt; We reported a 34-year-old pregnant woman in third trimester of pregnancy with a two-week history of reddish patches and pustules spread almost all over her body. She had a history of the same complaint in her latest pregnancy. The diagnosis of severe IH was made based on clinical, laboratory, and histopathology findings. She was prescribed 80 mg/day of oral prednisolone. The eruption and systemic symptoms gradually improved after 12 weeks of treatment. The dose was maintained until delivery before tapered gradually and stopped. The baby was born healthy, and there were not any new lesions. &lt;strong&gt;Discussion:&lt;/strong&gt; Given the possibility of fetal and maternal complications that are potentially lifethreatening, IH needs to be detected and treated right away. The mainstay of treatment for IH is systemic corticosteroids. Steroids control the eruption by preventing polymorphonuclear cells from migrating. Due to its limited placental transmission, prednisolone is regarded to be safe for uses during pregnancy. After 12 weeks of treatment of 80 mg daily prednisolone, the eruptions were resolved and there were not any side effects of steroid observed in both the mother and the baby. &lt;strong&gt;Conclusion:&lt;/strong&gt; Impetigo herpetiformis not only needs early treatment to prevent maternal and fetal complications but also the safety of the treatment chosen. High-dose oral prednisolone is considered effective and safe to control a severe case of IH as it has low placental transmission.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">498</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laila Tsaqilah*, Annisa Febrieza Zulkarnaen, Hartati Purbo Dharmadji, Risa Miliawati Nurul Hidayah, Erda Avriyanti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran- Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Harry Kurniawan Gondo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Haryanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ciplukan Fruit Extract (Physalis angulata L.) on IL-12 and Oxidative Stress in Mice Gestational Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ciplukan fruit extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DMG</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-12</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1121-1123</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by increased blood glucose levels that occur during pregnancy. Oxidative stress in hyperglycemia increases the inflammatory response in GDM by stimulating pro-inflammatory genes. IL-12 is a pro-inflammatory cytokine that is generally involved in inflammatory responses . This research aims to determine the effect of ciplukan fruit extract against IL-12, and Oxidative Stress in Gestational Diabetes Mellitus mice . The method used in this research is RAL (Completely Randomized Design). Analysis of cytokine levels using the ELISA reading method was followed by data analysis using the ANOVA test . The results showed that the treatment given gradually increased the highest cytokine levels in the P4 group showing the highest increase with IL-12 levels of 0.246 pg/mL, SOD of 0.160 U/mg protein, and MDA of 0.070 μmol/L. In this study it can be concluded that the P4 group showed the strongest effect in all parameters, indicating the potential of the agent or intervention as an immunomodulator and antioxidant, although it requires good management of oxidative stress.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1121</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Harry Kurniawan Gondo*, Elizabeth Haryanti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Wijaya Kusuma University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tabisa Diniso</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Gugulethu M. Miya</style></author><author><style face="normal" font="default" size="100%">Simon K. Kuria</style></author><author><style face="normal" font="default" size="100%">Yiseyon S. Hosu</style></author><author><style face="normal" font="default" size="100%">Opeoluwa O. Oyedeji</style></author><author><style face="normal" font="default" size="100%">Mike O. Ojemaye</style></author><author><style face="normal" font="default" size="100%">Ludwe Majiza</style></author><author><style face="normal" font="default" size="100%">Jerry O. Adeyemi</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Citrus Extract-Mediated Zinc Oxide Nanoparticles and Their Capacity to Attenuate Free Radicals and Inflammation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory capacity</style></keyword><keyword><style  face="normal" font="default" size="100%">Citrus plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Free Radical Scavenging Activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nova mandarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Zinc oxide nanoparticle green synthesis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1222-1233</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The exploitation of plant materials for the green synthesis of nanoparticles (NPs) for biological applications, is considered an eco-friendly technology because it does not involve the use of toxic chemicals. &lt;strong&gt;Objective: &lt;/strong&gt;The study was carried out to synthesize citrus extract-mediated ZnO NPs and evaluate their free radical scavenging and anti-inflammatory capacity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;ZnO NPs were green synthesized, using the peel and leaf aqueous extracts of three citrus plants: Nova mandarin, Satsuma mandarin and Eureka lemon. The citrus extract based ZnO NPs were characterized by UV-Vis and FTIR spectroscopy, microscopy (SEM and TEM), EDX and XRD analyses. They were screened against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) free radicals. Finally, their inhibitory effects against egg albumin denaturation (EAD) were determined spectrophotometrically. &lt;strong&gt;Results:&lt;/strong&gt; The six afforded biogenic NPs consistently exhibited FTIR vibrational band around 500 cm-1, which is characteristics of a metal oxide (Zn-O) band. They also showed UV-Vis absorption peaks at 387 and 415 nm, suggesting the formation of ZnO NPs. Nova mandarin peel (NMP) ZnO NPs exhibited the best DPPH and NO radical scavenging activities, with 50% inhibitory concentration (IC50) of 7.61±0.69 and 19.93±0.40 μg/mL, respectively. It also gave the best inhibition against EAD, with an IC50 of 14.80±1.29 μg/mL. Morphological assessment of NMP extract-based ZnO NPs revealed rod-shaped particles at 35-50 nm range. &lt;strong&gt;Conclusion: &lt;/strong&gt;It has been shown through this study that citrus extract based ZnO NPs, especially those prepared with NMP, may have the capacity to attenuate free radical release and inflammation in biological systems.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1222</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tabisa Diniso&lt;sup&gt;1&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;1*&lt;/sup&gt;, Gugulethu M. Miya&lt;sup&gt;1&lt;/sup&gt;, Simon K. Kuria&lt;sup&gt;2&lt;/sup&gt;, Yiseyon S. Hosu&lt;sup&gt;3&lt;/sup&gt;, Opeoluwa O. Oyedeji&lt;sup&gt;4&lt;/sup&gt;, Mike O. Ojemaye&lt;sup&gt;4&lt;/sup&gt;, Ludwe Majiza&lt;sup&gt;5&lt;/sup&gt;, Jerry O. Adeyemi&lt;sup&gt;1&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Mthatha, 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biological and Environmental Sciences, Walter Sisulu University, Mthatha, 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Business Management and Economics, Faculty of Economics and Financial Sciences.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, University of Fort Hare, Alice, 5700, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Vunikhaya (PTY)LTD, Burnshill Location, Keiskammahoek, 5670, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Handayani H.</style></author><author><style face="normal" font="default" size="100%">Renny Novi P.</style></author><author><style face="normal" font="default" size="100%">Andik Ferdiantoro</style></author><author><style face="normal" font="default" size="100%">Afira Febriani S. W.</style></author><author><style face="normal" font="default" size="100%">Rifky Dwi Aditya Iryawan</style></author><author><style face="normal" font="default" size="100%">Diaz Syafrie A.</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Mochammad Aqilah Herdiansyah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Combination Bitter, Ginger, Turmeric Extract in Mice: Acute and Sub Acute Toxicity Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute and Sub Acute Toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50.</style></keyword><keyword><style  face="normal" font="default" size="100%">SIJAKUN (bitter</style></keyword><keyword><style  face="normal" font="default" size="100%">turmeric)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">916-922</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Herbal plants are widely used as traditional medicine for generations. Some of them are bitter, in Indonesian called Sambiloto (&lt;em&gt;Andrographis paniculata&lt;/em&gt;), red ginger in Indonesian called Jahe merah (&lt;em&gt;Zingiber officinale&lt;/em&gt; &lt;em&gt;var rubrum&lt;/em&gt;), and turmeric in Indonesian called Kunyit (&lt;em&gt;Curcuma domestica&lt;/em&gt;). This study tested extracts containing a combination of three ingredients, hereinafter named 'SIJAKUN' extract (SambIloto, JAhe, KUNyit)”. This combination has good benefits for the body, especially as an anti-inflammatory and antioxidant. This study aims to measure the acute and subacute toxic effects of 'SIJAKUN' extract. This is a true experimental study. In the acute toxicity study, the SIJAKUN extract was given to 5 groups of mice a doses of 1000 mg/kg, 2,000 mg/kg, 3,000 mg/kg, 4,000 mg/kg, and 5,000 mg/kg. After being observed for 24 hours, the number of dead mice from each group was counted to calculate the LD50 of the 'SIJAKUN' extract. Whereas in subacute toxicity, 5 groups of mice were given 0.5 ml of CMCNa solution, 'SIJAKUN' extract at doses of 25 mg/kg, 75 mg/kg, 150 mg/kg, and 25 mg/kg ibuprofen, the test substance was given orally once daily for 28 days. Then an examination was carried out: SGOT, SGPT, BUN, and serum creatinine. the results of subsequent examinations were analyzed statistically. To assess the safety of the SIJAKUN combination, it is necessary to conduct research to determine the acute and sub acut toxicity of SIJAKUN to the liver and kidneys. Based on the results of acut toxixity study conducted, no experimental animals died at one dose of 1000, 2000, 3000, 4000 and 5000 mg/kgbb ‘SIJAKUN’ extract. Based on these results, the LD50 of 'SIJAKUN' extract was above 5000 mg/kgbb. Therefore, it can be said that 'SIJAKUN' extract is a non-toxic compound. In the subacute toxicity study, examination result of SGOT, SGPT, BUN, and serum creatinin was not change significantly, with P value &amp;gt; 0.05. This result indicating no significant difference between the control group and the treatment group. It can be said that the sub-acute toxicity test found that 'SIJAKUN' extract did not toxic for liver and kidney. In acute and subacute toxicity studies that has been carried out, 'SIJAKUN' extract was classified as a non-toxic compound, so it is safe to use as herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Handayani H.&lt;sup&gt;1&lt;/sup&gt;, Renny Novi P.&lt;sup&gt;1&lt;/sup&gt;, Andik Ferdiantoro&lt;sup&gt;1&lt;/sup&gt;, Afira Febriani S. W.&lt;sup&gt;1&lt;/sup&gt;, Rifky Dwi Aditya Iryawan&lt;sup&gt;1&lt;/sup&gt;, Diaz Syafrie A.&lt;sup&gt;1&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;2,3*&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;4,5,6,7&lt;/sup&gt;, Mochammad Aqilah Herdiansyah&lt;sup&gt;6,7,8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences,&amp;nbsp;Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and&amp;nbsp;Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Postgraduate School,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences,&amp;nbsp;Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Virtual Research Center for&amp;nbsp;Bioinformatics and Biotechnology, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Division of Research and Development,&amp;nbsp;Jalan Tengah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Science and Technology,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahmat Haji Saeni</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli Abdullah</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Agus Bintara Birawida</style></author><author><style face="normal" font="default" size="100%">Suriah</style></author><author><style face="normal" font="default" size="100%">Rika Handayani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Community-Based Electronic Recording and Reporting in Indonesia: Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Health</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Monitoring</style></keyword><keyword><style  face="normal" font="default" size="100%">Recording</style></keyword><keyword><style  face="normal" font="default" size="100%">Reporting</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">860-864</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Implementing electronic-based health information systems in Indonesia has shown a significant increase in the last decade. However, many problems still need to be solved that hinder the effectiveness of this system. Studies describing the implementation of electronic-based data collection, monitoring, and reporting show confusing results. &lt;strong&gt;Aim&lt;/strong&gt;: This review aims to evaluate the implementation of community-based electronic data collection, monitoring and reporting. &lt;strong&gt;Method:&lt;/strong&gt; PRISMA guidelines was used to conduct this review. Databases used to search relevant literature including PubMed, Sciencedirect, Willey Online Library, and Proquest. Authors independently screening and extracted the data from the eligible studies. CASP for qualitative study was used to assess the quality of the study.&lt;strong&gt; Result: &lt;/strong&gt;There are nine studies that matched with the inclusion criteria. Area of recording, monitoring, and reporting including maternal and child health, NCDs, and Tuberculosis. the challenges faced by Indonesia in implementing the ERMR including internet connections, access to electricity, absence of regulations, human resources, facilities, Fragmented application, Age, Pandemic, and lack of communication. Based on those barriers, infrastructure in supporting the implementation of ERMR is the most stated in the studies included. &lt;strong&gt;Conclusion:&lt;/strong&gt; The implementation of ERMR is crucial for the Indonesian government to address immediately, given the significantly substantial benefits for the health status of the Indonesian people. The availability of adequate infrastructure, especially in remote areas, will support satisfactory public health services.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">860</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahmat Haji Saeni&lt;sup&gt;1*&lt;/sup&gt;, Andi Zulkifli Abdullah&lt;sup&gt;2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, Agus Bintara Birawida&lt;sup&gt;2&lt;/sup&gt;, Suriah&lt;sup&gt;2&lt;/sup&gt;, Rika Handayani&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Phd Student, College of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, College of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nursing, College of Nursing and Midwifery, Megarezky University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Made Subhawa Harsa</style></author><author><style face="normal" font="default" size="100%">Andiani</style></author><author><style face="normal" font="default" size="100%">Sulistiawati</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Hanik Badriyah Hidayati</style></author><author><style face="normal" font="default" size="100%">Kuntaman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Study of Paracetamol vs Paracetamol Plus Acupressure for Pain Relief in Diabetic Neuropathy Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acupressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic neuropathic pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Type II diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Visual analogue scale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">602-605</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes Mellitus (DM) is a chronic metabolic disorder that causes neuropathy. Diabetic neuropathy causes severe pain and needs therapy to relieve its pain. In Indonesia, the therapy uses paracetamol, sometimes combined with acupressure. However, the efficacy of the combination therapy needs to be better understood.&lt;strong&gt; Purpose:&lt;/strong&gt; This study aimed to elucidate the efficacy of paracetamol vs paracetamol combined with acupressure for pain relief in diabetic neuropathy patients. &lt;strong&gt;Materials and methods:&lt;/strong&gt; This study used a cross-sectional study design. Total of 70 participants were agreed to involved in this study. The patients were then interviewed, and their visual analogue scale was assessed. The data was then analysed statistically using Pearson’s correlation. &lt;strong&gt;Result:&lt;/strong&gt; Out of the 70 patients diagnosed with type II DM, 40 had Diabetic Neuropathic Pain (DNP). Shockingly, most of the patients with type II DM and DNP were females, accounting for 33 out of 40 cases (82.50%). The study found a significant correlation between the type of therapy and the decrease in VAS scores for diabetic patients with neuropathic pain (p≤0.05). Patients treated with paracetamol and acupressure showed more improvement in the VAS score than those treated with only paracetamol. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study suggests that the combination treatment could benefit DNP as an analgesic for type II DM patients. Advanced study is required to be performed using larger samples so that accurate data can be obtained.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">602</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;I Made Subhawa Harsa&lt;sup&gt;1,2&lt;/sup&gt;, Andiani&lt;sup&gt;1,3&lt;/sup&gt;, Sulistiawati&lt;sup&gt;4&lt;/sup&gt;* , Lilik Herawati&lt;sup&gt;5&lt;/sup&gt;, Hanik Badriyah Hidayati&lt;sup&gt;6&lt;/sup&gt; , Kuntaman&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Wijaya Kusuma Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayus Diningsih</style></author><author><style face="normal" font="default" size="100%">Cory Linda Futri Harahap</style></author><author><style face="normal" font="default" size="100%">Elmi Sariani Hasibuan</style></author><author><style face="normal" font="default" size="100%">Rudi Dalimunthe</style></author><author><style face="normal" font="default" size="100%">Nefonavratilova Ritonga</style></author><author><style face="normal" font="default" size="100%">Haslinah Ahmad</style></author><author><style face="normal" font="default" size="100%">Anto J. Hadi</style></author><author><style face="normal" font="default" size="100%">Hapiz Arlanda Sani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cookies Formula for Oat (Avena sativa L.) and Plainnates (Musa Paradisiaca L.) as Alternative Food Ingredients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alternative Food.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cookies</style></keyword><keyword><style  face="normal" font="default" size="100%">King Banana</style></keyword><keyword><style  face="normal" font="default" size="100%">Oats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">910-915</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Cookies in circulation have a high amount of vegetable or animal fat (20-30% based on flour weight) and fiber content low Because material main cookies Which There is in market that is flour flour, necessary innovation for develop product &lt;em&gt;cookies that are low in calories&lt;/em&gt; and &lt;em&gt;have high fiber content,&lt;/em&gt; Wrong the only one with use material main oats (&lt;em&gt;Avena sativa&lt;/em&gt; L.). The aim of this research is to analyze whether OAT ( &lt;em&gt;Avena sativa&lt;/em&gt; L. ) and Raja banana (&lt;em&gt;Musa Paradisiaca &lt;/em&gt;L.) can be formulated as cookies that have low calorie content and sensory evaluation of cookies using color, taste, aroma and texture parameters. This research is true experimental research carried out in the laboratory. Cookies made with the composition of oats and plantain are F1 ( 120gr: 80gr), F2 (150gr: 50gr), F3 (180gr: 20gr). Based on the research results obtained, it is stated that the ash content, water content, carbohydrate content, protein content, fat content and total energy (calories) are respectively as follows: In the control (0.74%; 3.38%; 92 .2%; 2.62%; 4.8% and 422kcal), F1 (3.50%; 4.70%; 78.97%; 5.25%; 12.20% and 446 kcal), F2 ( 3.42%; 4.24%; 70.99; 8.75%; 18.00; .96% and 481%). The results of the sensory test stated the p value: 0.000, which means there is a difference. Oats ( &lt;em&gt;Avena sativa&lt;/em&gt; L. ) and plantains (&lt;em&gt;Musa Paradisiaca &lt;/em&gt;L.) can be formulated into low-calorie cookies. Based on the sensory evaluation, it was stated that there were differences in the panelists' preferences for the color, taste, aroma and texture of oat and plantain cookies. In order to carry out further analysis for the application of cookies to mice as a low-calorie diet food.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">910</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayus Diningsih&lt;sup&gt;1*&lt;/sup&gt;, Cory Linda Futri Harahap&lt;sup&gt;1&lt;/sup&gt;, Elmi Sariani Hasibuan&lt;sup&gt;1&lt;/sup&gt;, Rudi Dalimunthe&lt;sup&gt;1&lt;/sup&gt;, Nefonavratilova Ritonga&lt;sup&gt;2&lt;/sup&gt;, Haslinah Ahmad&lt;sup&gt;2&lt;/sup&gt;, Anto J. Hadi&lt;sup&gt;2&lt;/sup&gt;, Hapiz Arlanda Sani&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3,*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Health,&amp;nbsp;Aufa Royhan University, Padangsidimpuan, North Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Health,&amp;nbsp;Aufa Royhan University, Padangsidimpuan, North Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hilda Harun</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Abdul Salam</style></author><author><style face="normal" font="default" size="100%">Mondastri Korib Sudaryo</style></author><author><style face="normal" font="default" size="100%">H. Muh. Syafar</style></author><author><style face="normal" font="default" size="100%">A. Ummu Salmah</style></author><author><style face="normal" font="default" size="100%">Sudirman Natsir</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development and Feasibility Test of the Self-Management Hypertension (SMH) Application for Elderly People with Hypertension in Makassar City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Elderly</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Self Management</style></keyword><keyword><style  face="normal" font="default" size="100%">SMH Application</style></keyword><keyword><style  face="normal" font="default" size="100%">TAM.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">902-909</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The Self &lt;em&gt;Management Hypertension &lt;/em&gt;(SMH) application is a digital-based educational media solution to improve knowledge of elderly with HT in managing their disease independently, easy to use and can be accessed wherever they are. &lt;em&gt;Smartphone&lt;/em&gt; -based digital technology, Recently, it has become a very common tool needed by most people, including the elderly, not only as a communication tool but can also be used as a medium for education and information. Research &lt;strong&gt;Objectives:&lt;/strong&gt; This research aims to design the development of a prototype of the SMH application and to determine the feasibility of the SMH application for self-management of hypertension for the elderly. &lt;strong&gt;Method:&lt;/strong&gt; The research method used is &lt;em&gt;Research and Development &lt;/em&gt;(R&amp;amp;D). The research subjects for the expert validation test consisted of 3 experts. Meanwhile, the application trial subjects consisted of a one-on-one trial sample of 3 elderly people and a small group trial of 12 elderly people. Data collection uses the &lt;em&gt;Technology Acceptance&lt;/em&gt; Model (TAM) questionnaire which consists of 13 questions with 4 assessment aspects, namely the convenience aspect, usefulness aspect, trust aspect and user intention aspect. There are 4 Likert scale answer choices ranging from strongly agree to strongly disagree. &lt;strong&gt;Results:&lt;/strong&gt; Expert validation results show the percentage and eligibility criteria are 86.6%. The results of one-on-one trials show that the ease of application aspect is in the range of 3.25-4.00, the usefulness aspect is in the range of 3.00-4.00, the trust aspect is in the range of 3.67-4.00 and the user intention aspect is in the range of 3.00-4. .00. Small group trials showed an average convenience aspect of 3.52, an average usefulness aspect of 3.53, an average trust aspect of 3.69 and an average user intention aspect of 3.64. &lt;strong&gt;Conclusion&lt;/strong&gt;: The SMH application has decent content, is easy to use, very useful, and trustworthy, thereby increasing the intention of elderly people with HT to use the SMH application&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">902</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hilda Harun&lt;sup&gt;1*&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;2&lt;/sup&gt;, Abdul Salam&lt;sup&gt;3&lt;/sup&gt;, Mondastri Korib Sudaryo&lt;sup&gt;4&lt;/sup&gt;, H. Muh. Syafar&lt;sup&gt;5&lt;/sup&gt;, A. Ummu Salmah&lt;sup&gt;6&lt;/sup&gt;, Sudirman Natsir5, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Student in Public Health Sciences, Public Health Sciences Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Promoter and Co Promoter, Professor Department of Epidemiology, Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Doctoral Department of Nutrition, Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar INDONESIA. 4Professor, Department of Epidemiology, Faculty of Public Health, University of Indonesia, Jakarta INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Health Promotion and Behavioral Sciences, Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professors at the Department of&amp;nbsp;Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Professor, Department of Environmental Health, Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suparmi</style></author><author><style face="normal" font="default" size="100%">Sumarto</style></author><author><style face="normal" font="default" size="100%">Hendro Ekwarso</style></author><author><style face="normal" font="default" size="100%">Isna Rahma Dini</style></author><author><style face="normal" font="default" size="100%">Ranika Paramita</style></author><author><style face="normal" font="default" size="100%">Syafrani</style></author><author><style face="normal" font="default" size="100%">Taufik Hidayat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Diversification, Organoleptic and Chemical Quality Characteristics of Processed Products Based on Thorn Fish (Hexanematichthys sagor) Smoke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diversification</style></keyword><keyword><style  face="normal" font="default" size="100%">Ecowisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Healthy</style></keyword><keyword><style  face="normal" font="default" size="100%">Nutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">606-609</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The potential of Rupat Island's marine natural resources can be seen from the diversity of its marine and mangrove ecosystems. This coastal area has natural resource potential, both marine products and no less important is its marine ecotourism area. The marine tourism area is found at Pesona Beach, Lampin Beach, Ketapang Beach, Makeruh Beach, and Putri Sembilan Beach which have an important role in increasing regional income. The aim of the research is to increase the potential of processed fishery products as souvenirs and tourism. The research method is an experiment using a completely randomized design, with treatments MS0 (smoked fish control), MS1 (smoked fish rendang) and MS2 (smoked fish rendang) and MS3 (Flossed fish). smoke) repeated 3 times. The parameters analyzed are organoleptic (appearance, texture, aroma, taste). The results of the research showed that the best treatment was MS2 (Smoked fish sorondeng) which was liked by the panelists which had the characteristics of a bright yellow color, the aroma of burnt coconut, the texture of mersik was not hard and crunchy, and the taste was savory, with a taste score of 8.6, aroma 8.4 , appearance 8.8, texture 8.5. This product has the characteristics of a bright brownish yellow color, a non-fishy aroma, a smooth texture and a very savory taste (umami). From the results of the threshold test on functional flavor powder, the threshold value was obtained, namely at a concentration of 9% with a taste value of 8.6, aroma 8. .4, appearance 8.8, texture 8.5. This product has the characteristics of a bright yellowish white color, a non-fishy aroma, a smooth texture and a very savory taste (umami)&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">606</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suparmi&lt;sup&gt;1&lt;/sup&gt;*, Sumarto&lt;sup&gt;1&lt;/sup&gt;, Hendro Ekwarso&lt;sup&gt;2&lt;/sup&gt;, Isna Rahma Dini&lt;sup&gt;3&lt;/sup&gt;, Ranika Paramita&lt;sup&gt;3&lt;/sup&gt;, Syafrani&lt;sup&gt;4&lt;/sup&gt;, Taufik Hidayat&lt;sup&gt;5&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fisheries Product Technology, Riau University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Economics, Development Economics, Riau University.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Univeristy of Hang Tuah, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Agrotechnology Study Program, Faculty of Agriculture, Universty of Lancang Kuning, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Agroindustry, National Innovation Research Agency, Laptiab Building 614, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lailatul Fadliyah</style></author><author><style face="normal" font="default" size="100%">Hendy Hendarto</style></author><author><style face="normal" font="default" size="100%">Lestari Sudaryanti</style></author><author><style face="normal" font="default" size="100%">Imam Susilo</style></author><author><style face="normal" font="default" size="100%">Anwar Ma’ruf</style></author><author><style face="normal" font="default" size="100%">Emuliana Sulpat</style></author><author><style face="normal" font="default" size="100%">Endah Sri Wijayanti</style></author><author><style face="normal" font="default" size="100%">Maya Septriana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Ethanol Extract of Phyllanthus niruri l on Malondialdehyde (MDA) Expression and Extracellular Signal- Regulated Protein Kinase-1 (ERK-1) on Vaginal Epithelial Cell Thickness in Menopausal Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ERK-1</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopausal Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri l</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginal epithelium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1305-1310</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Menopause is the condition of the ovaries stops produce estrogen so that resulting in vaginal bleeding atrophy that is become dry cause pain moment relate sexual so that lower quality life. The ROS pathway with MAPK regulates proliferation, differentiation, motility, and survival cell life. Research purposes is know influence giving extract Phyllanthus niruri l against Malondialdehyde (MDA) expression and Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) expression against thickness cell vaginal epithelium of menopausal model mice. Material from Phillantus niruri l processed become extract. Treatment animal try mice (mus muscullus) first acclimatized during one next week done ovariectomy of both ovaries, after two weeks checked vaginal examination to be sure phase diestrus (menopause). Stage treatment given extract for 21 days with dose different 14 mg, 28 mg and 56 mg/20gBW/ day. &lt;strong&gt;Methods: &lt;/strong&gt;True Experimental research method with Post Test only with control group design. Data analysis used one way ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;The research group that produced the highest average expression of Malondialdehyde (MDA) was the control group. The highest expression of Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) was in the P3 treatment group (dose 56 mg/20gBW/day). The results of statistical analysis showed that there was a significant effect of Phyllanthus niruri l extract on decreasing MDA expression with a sig value of 0.000 &amp;lt; p = 21 0.001 and increasing ERK-1 with a sig value of 0.000 &amp;lt; 0.001, but there was no effect on increasing the thickness of the vaginal wall epithelial cells in menopausal model mice. with a sig value of 0.220 &amp;gt; 0.05. &lt;strong&gt;Conclusion: &lt;/strong&gt;The three doses of phillantus niruri decreased MDA and increased ERK-1. The Folin-Ciocalteau.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1305</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lailatul Fadliyah&lt;sup&gt;1,5&lt;/sup&gt;, Hendy Hendarto&lt;sup&gt;2*&lt;/sup&gt;, Lestari Sudaryanti&lt;sup&gt;3&lt;/sup&gt;, Imam Susilo&lt;sup&gt;4&lt;/sup&gt;, Anwar Ma’ruf&lt;sup&gt;5&lt;/sup&gt;, Emuliana Sulpat&lt;sup&gt;5&lt;/sup&gt;, Endah Sri Wijayanti&lt;sup&gt;5&lt;/sup&gt;, Maya Septriana&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetric Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Midwifery Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Jiang Xi University of Traditional Chinese Medicine, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Fajar Utami</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Hayun Hayun</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Syamsu Nur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Bacterial Enzymes on Reducing Chlorogenic Acid Levels in Cascara Robusta Coffee (Coffea canephora L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bacillus subtilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cascara</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorogenic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">332-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coffee skin by-products, namely cascara, have several benefits, namely can ward off free radicals, with the ability of cascara to ward off free radicals so that cascara can potentially prevent the emergence of cancer cells. Cascara contains active compounds caffeine 1.3%, chlorogenic acid 2.6%, and caffeic acid 1.6%. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine chlorogenic acid levels in decaffeinated robusta coffee (Coffea canephora L.) and see the influence of Bacillus subtilis bacteria on reducing chlorogenic acid levels. &lt;strong&gt;Methods:&lt;/strong&gt; The experiment was conducted from June to August 2022 in the Pharmacy Laboratory, Faculty of Mathematics and Natural Sciences, Universitas Pakuan, Indonesia. Cascara robusta coffee is fermented using Bacillus subtilis with a concentration of 6% and a time of 24 hours. After fermentation, the extraction is carried out using the UAE (Ultrasonic Assisted Extraction) method. The chlorogenic acid levels and zero control of cascara robusta coffee obtained were then analyzed using Statistical Package for the Social Science (SPSS) with the Paired sample t-test method previously carried out with normality test and homogeneity test first. &lt;strong&gt;Results:&lt;/strong&gt; The study found chlorogenic acid levels produced from cascara robusta coffee that had undergone decaffeination. Quantitative analysis of chlorogenic acid levels in cascara robusta coffee was carried out using HPLC mobile phase methanolwater (adjust Orthoposphat pH 2.4), flow rate 0.7 mL/minute, with an isocratic system of an average of 14.8597%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Chlorogenic acid levels in robusta coffee cascara decaffeinated by microbial enzymes can affect chlorogenic acid levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">332</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Fajar Utami&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1*&lt;/sup&gt;, Hayun Hayun&lt;sup&gt;3&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;4,5,6&lt;/sup&gt;, Syamsu Nur&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Phytochemistry and Pharmacognosy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Math and Science, Universitas Pakuan, Jl. Raya Pakuan 1 Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Pharmaceutical Chemistry, Almarisah Madani University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manggiasih Dwiayu Larasati</style></author><author><style face="normal" font="default" size="100%">Silvia W. Lestari</style></author><author><style face="normal" font="default" size="100%">Mulyoto Pangestu</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Cryopreservation on the Sperm Ultrastructure of Mus Musculus Albinus Strain DDY: Comparison of Nakagata vs Modified vs Kitazato Cryoprotectants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cryopreservation</style></keyword><keyword><style  face="normal" font="default" size="100%">glycerol</style></keyword><keyword><style  face="normal" font="default" size="100%">mice sperm</style></keyword><keyword><style  face="normal" font="default" size="100%">raffinose</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscope</style></keyword><keyword><style  face="normal" font="default" size="100%">Trehalose</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">563-569</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sperm morphology analysis is very necessary to understand male fertility and the etiology of infertility. Currently, scanning electron microscopy (SEM) has been widely used to determine surface topology. In this study, we will compare the effects of spermatozoa cryopreservation using three different types of cryoprotectants, namely Nakagata, modification and Kitazato. The cryoprotectant compositions used are Nakagata (raffinose and skim milk), modified (glycerol and raffinose) and Kitazato (glycerol and trehalose). &lt;strong&gt;Methods:&lt;/strong&gt; SEM analysis was carried out on 8 sperm samples before cryopreservation and after the freeze-thaw process. &lt;strong&gt;Results:&lt;/strong&gt; The results obtain showed that cryoprotectant modification was able to protect spermatozoa morphology better than Nakagata and Kitazato. Analysis revealed damage to plasma membrane, acrosome and loss of mitochondria in all treatment groups compared to fresh sperm. SEM showed obvious signs of post-thaw damage such as missing plasma membranes, sperm showing damaged acrosomes and mitochondria in the middle showing structural disorganization. &lt;strong&gt;Conclusion: &lt;/strong&gt;SEM revealed that cryopreservation caused ultrastructural damage to mice sperm due to freezing and thawing. These details provide valuable data for further research to minimize the damage caused by cryopreservation to mice sperm. Apart from that, further examination using TEM is recommended to obtain a more comprehensive picture.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Manggiasih Dwiayu Larasati&lt;sup&gt;1&lt;/sup&gt;, Silvia W. Lestari&lt;sup&gt;2&lt;/sup&gt;,* Mulyoto Pangestu&lt;sup&gt;3&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;4&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;5-7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darmin Dina</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Hasnawati Amqam</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Anang S. Otoluwa</style></author><author><style face="normal" font="default" size="100%">Yulianah Sulaiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Giving Iodized Salt and Multi Micro Nutrients to Pregnant Women on the Nutritional Status of Pregnant Women in Majene Regency</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pregnant women; Iodine Salt; Multi Micro Nutrient Supplement; Nutritional status.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">779-784</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Background:&lt;/strong&gt; Maternal nutritional needs during pregnancy increase due to physiological, metabolic and anatomical changes. If the intake is insufficient, there will be deficiencies in both macro and micro nutrients. Multimicronutrient deficiency will affect the growth and anemia status of pregnant women. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine the effect of giving iodized salt and Multi Micronutrient Supplements to pregnant women on hemoglobin levels, body weight, iodine levels in urine and pregnancy outcomes. &lt;strong&gt;Method:&lt;/strong&gt; This research is an analytical research using an experimental design that controls several nonexperimental variables and there is a control group as a comparison group to understand the effect of treatment. Determining the sample in this study used a random experimental method where 200 pregnant women were used as the research sample. The results showed that there was a significant change or increase in Hb levels (p=0.006; &amp;lt;0.000; &amp;lt;0.000), body weight (p=0.001; &amp;lt;0.000; &amp;lt;0.000), lila (&amp;lt;0.0015; &amp;lt;0.000; &amp;lt;0.000 ), Iodine levels (&amp;lt;0.000; &amp;lt;0.000; &amp;lt;0.000), between the group given iodized salt and MMS and the group given MMS. In this study, in the group of pregnant women who received iodized salt and MMS intervention, on average there was an increase or change in HB levels, iodine levels, mother's weight, baby's weight and abdominal length and circumference compared to those who received MMS. for pregnant women is to regularly maintain nutritional intake during pregnancy, especially consuming iodized salt and MMS which is beneficial for the health of pregnant women and the baby they are carrying.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">779</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darmin Dina&lt;sup&gt;1,2*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Veni Hadju&lt;sup&gt;4&lt;/sup&gt;, Hasnawati Amqam&lt;sup&gt;5&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;6&lt;/sup&gt;, Wahiduddin&lt;sup&gt;7&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;8&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;9&lt;/sup&gt;, Anang S. Otoluwa&lt;sup&gt;10&lt;/sup&gt;, Yulianah Sulaiman&lt;sup&gt;11&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;D III Midwifery Study STIKES Bina Bangsa Majene Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Hasanuddin University FKM Nutrition Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Hasanuddin University FKM Public Health Science Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Hasanuddin University FKM Epiodiomology Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Hasanuddin University FKM Epidiomology Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Hasanuddin University&amp;nbsp;FKM Environmental Health Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Hasanuddin University FKM Bioastatistics Study Program, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;UNTIKA Luwuk Faculty of Public Health, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;D III Midwifery Study STIKES Bina Bangsa Majene Program, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zuraida</style></author><author><style face="normal" font="default" size="100%">Silvia Werdhy Lestari</style></author><author><style face="normal" font="default" size="100%">Mulyoto Pangestu</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Glutathione Supplementation in Cryoprotectant Modification on Tyrosine Phosphorylation, Acrosin Expression and Acrosome Reaction of Post-Thawing Spermatozoa Quality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acrosin expression</style></keyword><keyword><style  face="normal" font="default" size="100%">acrosome reaction</style></keyword><keyword><style  face="normal" font="default" size="100%">CPA modification</style></keyword><keyword><style  face="normal" font="default" size="100%">glutathione (GSH)</style></keyword><keyword><style  face="normal" font="default" size="100%">spermatozoa cryopreservation</style></keyword><keyword><style  face="normal" font="default" size="100%">tyrosine phosphorylation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">554-562</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Tyrosine phosphorylation, acrosin, and acrosome reaction play an important role in fertilisation. However, cryopreservation causes changes in tyrosine phosphorylation, acrosin expression, and acrosome reaction which affect the quality of spermatozoa. Cryoprotectant media added with antioxidants is needed to protect Spermatozoa from the effects of cryopreservation so that the quality of spermatozoa can be maintained. &lt;strong&gt;Objectives:&lt;/strong&gt; This research examined the effect of glutathione (GSH) supplementation in cryopreservation media on tyrosine phosphorylation, acrosin expression, and acrosome reaction. In this research, pure modified Cryoprotectant (CPA) was compared with CPA supplemented with GSH in three different concentrations. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The research sample was male mus musculus albinus strain Deutchland Denken Yoken (DDY). Mice spermatozoa was cryopreserved and several parameters were measured including tyrosine phosphorylation, acrosin expression, and acrosome reaction. &lt;strong&gt;Results:&lt;/strong&gt; The addition of GSH to the modified CPA increased tyrosine phosphorylation, acrosin expression, and acrosome reaction (maintaining acrosome integrity). The group with 1.00 mM GSH obtained the highest results among the other groups. Significant increases were found in tyrosine phosphorylation, acrosin expression, and acrosome reaction after the addition of 1.00 mM GSH. &lt;strong&gt;Conclusion:&lt;/strong&gt; Glutathione supplementation in modified CPA can increase tyrosine phosphorylation, acrosin expression, and acrosome reaction of frozen-thawed spermatozoa. Treatment using GSH at a dose of 1.00 mM is the most effective and modification of CPA with the addition of glutathione can improve the tyrosine phosphorylation, acrosin expression and acrosome reaction in cryopreserved spermatozoa.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">554</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zuraida&lt;sup&gt;1,2&lt;/sup&gt;, Silvia Werdhy Lestari&lt;sup&gt;3&lt;/sup&gt;,*, Mulyoto Pangestu&lt;sup&gt;4&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;6-8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia; Jl. Salemba Raya No. 6, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Midwifery, Faculty of Health, Universitas Fort de Kock Bukittinggi, Jl. Soekarno Hatta No. 11, Bukittinggi, Sumbar 26117 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Education Program in Reproduction and Development, Department of Obstetrics and Gynecology, School of Clinical Sciences, Monash University, Victoria, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Drug Development Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Human Cancer Research Center, Indonesia Medical Education and Research Institute (IMERI), Universitas Indonesia, Jalan Salemba Raya No. 6, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lina Fitriani</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Masyitha Muis</style></author><author><style face="normal" font="default" size="100%">Nurpudji Astuti Taslim</style></author><author><style face="normal" font="default" size="100%">Sri Sumarni</style></author><author><style face="normal" font="default" size="100%">M.Bambang Uswatul Firdaus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Moringa Oleifera Plus Royal Jelly Capsules in The Gestation Age and Placenta Weight of Newborns in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adverse Birth Outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1177-1182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The incidence of adverse birth outcomes (ABO) in low- and middle-income countries (LIMC) remains significantly elevated. Moringa oleifera (MO), rich nutritional profile, offers to reduce ABO. Therefore, this study aimed to evaluate the impact of MO plus royal jelly capsules on the gestational age and placental weight of newborns in Indonesia. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A quasi-experimental design setup in the Banggai district, Central Sulawesi Province. The study used a purposive sampling of 80 pregnant women from each sub-district. Moilong District received MRJ, while South Batui District was the Multiple Micronutrient Supplement (MMS) control group. Both groups took one capsule daily for six months. Data analysis using SPSS v28 for Windows, including Chi-square/Fisher's exact test, Kolmogorov- Smirnov test, Mann-Whitney test, and ANCOVA, with a significance level of p &amp;lt; 0.05. &lt;strong&gt;Results: &lt;/strong&gt;The demographic characteristics in both groups were similar (p &amp;gt; 0.05), except for BMI (p=0.031). Pregnancy outcomes data were also identical (p &amp;gt; 0.05). The Mann-Whitney test did not show a significant difference (p = 0.696) in the gestational age of delivery between the groups. However, there was a significant difference (p &amp;lt; 0.05) in the PW variable within the MRJ group, as shown by the Mann-Whitney test. After adjusting for BMI in PW, the ANCOVA test indicated a significant difference (p = 0.001).&lt;em&gt; Conclusions: &lt;/em&gt;The study concludes that MRJ and MMS interventions are effective and safe in preventing ABO in newborns based on gestational age and placental weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lina Fitriani&lt;sup&gt;1,2*&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Masyitha Muis&lt;sup&gt;5&lt;/sup&gt;, Nurpudji Astuti Taslim&lt;sup&gt;6&lt;/sup&gt;, Sri Sumarni&lt;sup&gt;7&lt;/sup&gt;, M.Bambang Uswatul Firdaus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Health, Mega Buana University, Palopo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Sciences, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Midicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratnawati Ratnawati</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Atina Hussaana</style></author><author><style face="normal" font="default" size="100%">Arrizki Azka Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tender Coconut Water Powder Enriched with Vitamin E in Preventing Oxidative Stress of Diabetes Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Tender coconut water powder; oxidative stress; Diabetes mellitus; spray drying; freeze drying</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1062-1068</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes mellitus (DM) is associated with increased oxidative stress and higher mortality rates. Analysis is needed to identify compounds in natural foods that can prevent oxidative stress. According to previous studies, tender coconut waterwith added vitamin E is more effective in preventing oxidative stress caused by DM compared to plain tender coconut water. This development is necessary to provide added value and practicality. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the potential of tender coconut water powder inriched with vitamin E on male rats diabetes by measuring the oxidative stress (SOD, GPx, MDA, IL-1, IL-6, TNF-α, and CRP levels). &lt;strong&gt;Methods:&lt;/strong&gt; An experimental method was used with a posttest control group design. A total of 36 male Wistar rats used were randomly divided into 6 groups namely normal; DM; P1 (type 2 DM + Spray Drying tender coconut water powder); P2 (type 2 DM + Spray Drying tender coconut water powder + vitamin E); P3 (type 2 DM + Freeze Drying tender coconut water powder); and P4 (type 2 DM + Freeze Drying tender coconut water powder + vitamin E). Type 2 DM induction was carried out using Streptozotocin (STZ) 65 mg/kgBW and Nicotinamide 230 mg/kgBW. Tender coconut water powder was administered daily for 4 weeks beginning on the 3rd day after inducing DM. The data obtained were analyzed using the One Way Analysis of Variance test (ANOVA).&lt;strong&gt; Result:&lt;/strong&gt; The results showed that the average levels of SOD and GPx in P4 were higher compared to P2, while MDA, IL-1, IL-6, TNF α, and CRP in P4 were lower compared to P2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Tender coconut water powder enriched with vitamin E effectively prevented oxidative stress, as indicated by increased SOD and GPx, along with decreased MDA, IL-1, IL-6, TNF α, and CRP levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1062</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratnawati Ratnawati&lt;sup&gt;1&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;1*&lt;/sup&gt;, Atina Hussaana&lt;sup&gt;2&lt;/sup&gt;, Arrizki Azka Pratama&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Resident, Faculty of Medicine, Universitas Diponegoro Semarang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Misroh Mulianingsih</style></author><author><style face="normal" font="default" size="100%">Suriah Suriah</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Veny Hadju</style></author><author><style face="normal" font="default" size="100%">Dea Wulandari</style></author><author><style face="normal" font="default" size="100%">Andi Ummu Salmah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of Booklet and Images Game Education in Anemia Adolescent Women on Anemia Prevention Knowledge, Attitudes and Behavior</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent women</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Attitudes</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Booklet</style></keyword><keyword><style  face="normal" font="default" size="100%">Image Game Education</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1183-1187</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background :&lt;/strong&gt; Risk factors for anemia in adolescents are lack of education, as well as adolescents inability to apply the information obtained in daily life. Effective health education improving adolescents knowledge, attitudes, and behaviors related to health. &lt;strong&gt;Objective :&lt;/strong&gt; This study aims to test the effectiveness of Booklet and Image game education in adolescent girls on knowledge, attitudes, and behaviors to prevennt anemia. Participants were young women aged 15-19 years in the work area of the bayan Health Center and Gangga Health Center, who were selected through a screening process of 186 participants. each location had 93 respondents. &lt;strong&gt;Method : &lt;/strong&gt;usiang a quasi-experimental two-group pre-test post-test design. In both groups, a pre-test was carried out furthermore, the intervention group was given health education through booklets and image game education, and the control group received health education with booklets. After the intervention was carried out, a pot-test was carried out on both groups. &lt;strong&gt;Results : &lt;/strong&gt;Coherence analysis showed that the control group (booklet), adolescent girl with anemia who received the booklet and image game education in the intervention group reported better knowledge about anemia (p=0,000, n2 p=0,727)attitudes about anemia (p=0,000, n2 p=0,698), and behavior of adolescent girls with anemia between the intervention group and the control group were much different after being given with anemia between the intervention group and the control group were much different after being given booklets and image game education compared to adolescent girls who only received booklets. &lt;strong&gt;Conclusion :&lt;/strong&gt; A multifaceted approach to health education can have a significant positive impact, especially when it involves interactive elements.therefore, the same educational program can be applied in various places to increase the effectiveness of a program or activity goal&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1183</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Misroh Mulianingsih&lt;sup&gt;1,5&lt;/sup&gt;, Suriah Suriah&lt;sup&gt;2&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;3&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;4&lt;/sup&gt;, Veny Hadju&lt;sup&gt;3&lt;/sup&gt;, Dea Wulandari&lt;sup&gt;5&lt;/sup&gt;, Andi Ummu Salmah&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Study Program, Faculty of Public Health, Hasanuddin University – INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Mataram Yarsi College of Health Sciences, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neni Wahyu Hastuti</style></author><author><style face="normal" font="default" size="100%">Delfitri Munir</style></author><author><style face="normal" font="default" size="100%">Reno Keumalazia Kamarlis</style></author><author><style face="normal" font="default" size="100%">Bintang Yinke Magdalena Sinag</style></author><author><style face="normal" font="default" size="100%">Adang Bachtiar</style></author><author><style face="normal" font="default" size="100%">Farhat</style></author><author><style face="normal" font="default" size="100%">Amira Permatasari Tarigan</style></author><author><style face="normal" font="default" size="100%">Delyuzar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Eosinophil Cell and Mass Appearance in Atypical Mycobacterium Infection of Lymphadenitis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atypical mycobacterium</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytology</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">664-667</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Atypical mycobacterium (ATM) is acid fast bacilli not including tuberculosis and may had opportunistic feature in environment either in air or soil. While symptoms of ATM infection may look similar with typical tuberculosis, these specific group of disease were harder to treat and would necessitate longer antibiotics consumption. While PCR may readily available to detect ATM, anatomical pathology method such as biopsy may be a cheaper alternative in low-resource settings to differentiate between atypical and typical mycobacterium infection. &lt;strong&gt;Aim:&lt;/strong&gt; To analyze correlation between eosinophil cells and eosinophil mass with ATM in lymphadenopathy patient. &lt;strong&gt;Methods: &lt;/strong&gt;This study is an analytical observational study with cross-sectional design which aimed to review diagnostic abilities of eosinophil cell and mass to detect ATM. Patient would undergo both PCR as gold standard of diagnosis and cytology biopsy aspiration as comparative diagnostic modalities. Data would be presented from SPSS v. 25. &lt;strong&gt;Results:&lt;/strong&gt; We collected 70 subjects that fulfill inclusion and exclusion criteria. Most samples were dominated by female in relatively young age. There are 37 patients with ATM in which 75,7% patients cytology result shown expression of eosinophil cells and 71,4% patients shown eosinophilic mass. Chi-square test revealed that statistical significance existed between eosinophilic cells with ATM. However, such statistical significance was not found between eosinophilic mass and ATM. &lt;strong&gt;Conclusion:&lt;/strong&gt; Eosinophilic cell can be used as alternative diagnostic modalities in diagnosing ATM. Further studies should further examine pathophysiological correlations and diagnostic power.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">664</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Neni Wahyu Hastuti&lt;sup&gt;1&lt;/sup&gt;*, Delfitri Munir&lt;sup&gt;2&lt;/sup&gt;, Reno Keumalazia Kamarlis&lt;sup&gt;3&lt;/sup&gt;, Bintang Yinke Magdalena Sinaga&lt;sup&gt;4&lt;/sup&gt;, Adang Bachtiar&lt;sup&gt;5&lt;/sup&gt;, Farhat&lt;sup&gt;2&lt;/sup&gt;, Amira Permatasari Tarigan&lt;sup&gt;4&lt;/sup&gt;, Delyuzar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;6&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Philosophy Doctor in Medicine Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ear, Nose, Throat, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomical Pathology, dr Zainoel Abidien Hospital, Universitas Syiah Kuala, Banda Aceh, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Health Policy and Administration, School of Public Health, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Honnesh N H</style></author><author><style face="normal" font="default" size="100%">Santanu Saha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anti-oxidant Activity and Flavonoid Content in Macaranga peltata Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Fraction</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Luteolin</style></keyword><keyword><style  face="normal" font="default" size="100%">Macaranga peltata</style></keyword><keyword><style  face="normal" font="default" size="100%">MPCF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1217-1221</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Macaranga peltata is a woody shrub and tree found in forest of Western Ghats of India. The leaves of M. peltata are large so used to wrap sweets in kerala. The plant is used in folk medicine and siddha medicine to treat fever, cough, wound and ulcers. There is very limited research has been conducted on exploring this plant medicinal properties and phytochemical estimation. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; In the present study attempt was made to know the antioxidant activity of MPCF by DPPH assay, FRAP assay and H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay methods and Optimization of mobile phase by TLC method and supporting major flavonoid content quantification by HPTLC method &lt;strong&gt;Results:&lt;/strong&gt; The result shown the Chloroform fraction has significant antioxidant activity of IC&lt;sub&gt;50&lt;/sub&gt; value of 123.71(DPPH assay), 185.85(FRAP assay) and 204.31(H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; assay). The TLC method optimum mobile phase was found to be Toluene: Ethyl acetate: Formic acid (5:4:0.2). The standard flavonoids used are Luteolin, Diosmin and ellagic acid. The HPTLC method results shown MPCF was found to contain 11.70% Luteolin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1217</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Honnesh N H&lt;sup&gt;1&lt;/sup&gt;, Santanu Saha&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore - 560 064, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Panner, Deralakatte, Mangaluru-575018, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Juana E. Chávez-Flores</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Maria J. Abanto-Vaella</style></author><author><style face="normal" font="default" size="100%">César D. Gamarra-Sánchez</style></author><author><style face="normal" font="default" size="100%">Yuri F. Curo-Vallejos</style></author><author><style face="normal" font="default" size="100%">Marco L. Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Icela M. Rodriguez-Haro</style></author><author><style face="normal" font="default" size="100%">Flor Soriano-López</style></author><author><style face="normal" font="default" size="100%">Renato Cueva- Veneros</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Acute Toxicity of the Ethanolic Extract of the Rhizome of Zingiber officinale Roscoe in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity test</style></keyword><keyword><style  face="normal" font="default" size="100%">Biochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">323-331</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ginger has pharmacological activities such as anticancer, antidiabetic, antioxidant, antimicrobial, anti-neuroinflammatory, and chemotherapy-induced nausea and vomiting. &lt;strong&gt;Objective:&lt;/strong&gt; The research aims to evaluate the acute toxicity of the ethanolic extract of the rhizome of Zingiber officinale Roscoe in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extract was administrated at doses of 300 and 2000 mg/ Kg/day to female and male rats. Changes in body weight were determined during the 14-day treatment period, and on the last day of treatment, blood was drawn, and euthanasia was performed, removing organs for histological analysis. Biochemical parameters were measured. &lt;strong&gt;Results:&lt;/strong&gt; The body weight of the research specimens not show statistically significant variation. In the liver, mild lymphocytic portal inflammation and moderate hepatic steatosis occurred at doses of 2000 mg/kg/day. The kidneys exhibited a mild infiltration around the renal tubules and glomeruli at the same dose. The brain showed a slight increase in the count of astrocytes with focal glial reaction at the highest dose. The stomach and heart also showed mild inflammatory processes at the dose of 2000 mg/kg/day. In biochemical parameters, statistically significant differences were observed between the dose of 2000 mg/Kg/day and the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanolic extract of the rhizome of Z. officinale in rats revealed histopathological changes in the liver, kidneys, brain, stomach, and heart, besides changes in biochemical parameters at doses of 2000 mg/Kg/day.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;2&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;4&lt;/sup&gt;, Maria J. Abanto-Vaella&lt;sup&gt;4&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;1&lt;/sup&gt;, Yuri F. Curo-Vallejos&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;3&lt;/sup&gt;, Icela M. Rodriguez- Haro&lt;sup&gt;3&lt;/sup&gt;, Flor Soriano-López&lt;sup&gt;3&lt;/sup&gt;, Renato Cueva-Veneros&lt;sup&gt;5&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Frontera, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wildan Harisma</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">Indar</style></author><author><style face="normal" font="default" size="100%">Ummu Salmah</style></author><author><style face="normal" font="default" size="100%">Syamsuar Manyullei</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Factors Affecting the Realization of Non-Physical Special Allocation Funds in The Health Sector at the Baubau City Health Office</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Budget Realization</style></keyword><keyword><style  face="normal" font="default" size="100%">Human Resources</style></keyword><keyword><style  face="normal" font="default" size="100%">Implementation</style></keyword><keyword><style  face="normal" font="default" size="100%">Leadership</style></keyword><keyword><style  face="normal" font="default" size="100%">Planning</style></keyword><keyword><style  face="normal" font="default" size="100%">Regulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">393-399</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Failure of meeting the budget realization target can result in the loss of spending benefits, because not all of the funds allocated can be utilized by the government which means there are idle funds. This study aims to investigate the factors that affect budget Realization. This study was approached using mixed method design, using a saturated sample technique where the sample used was the entire population of financial managers within the scope of the Baubau City’s Health Office and Community Health Center totaling 76 respondents. The data were collected by questionnaire techniques and in-depth interviews with 6 informants and analyzed by univariate analysis techniques, bivariate with Chi Square formula, and multivariate logistic regression analysis. The results showed that budget planning (p = 0.000), budget implementation (p = 0.000), human resources (p = 0.000), regulation (p = 0.001), and leadership (p = 0.012) influence on budget Realization. The results of logistic regression analysis show that budget planning is the most influential factor on budget Realization with p value of 0.002&amp;lt;0.005 and OR 11.353. Budget planning, budget implementation, human resources, regulations and leadership factors influence budget realization. Related parties are expected to improve the quality of human resources in the field of planning and budgeting division, which in turn, can increase budget realization.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">393</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wildan Harisma&lt;sup&gt;1*&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Amran Razak&lt;sup&gt;2&lt;/sup&gt;, Indar&lt;sup&gt;2&lt;/sup&gt;, Ummu Salmah&lt;sup&gt;3&lt;/sup&gt;, Syamsuar Manyullei&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biostatistics/KKB, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siwaporn Praman</style></author><author><style face="normal" font="default" size="100%">Narudol Teerapattarakan</style></author><author><style face="normal" font="default" size="100%">Thaneeya Hawiset</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Garcinia cowa Leaf Ethanolic Extract Induces Vasorelaxation Through eNOS/NO/sGC Pathway, Potassium, and Calcium Channels in Isolated Rat Thoracic Aorta</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ca2+ channel.</style></keyword><keyword><style  face="normal" font="default" size="100%">Endothelium</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa</style></keyword><keyword><style  face="normal" font="default" size="100%">K+ channel</style></keyword><keyword><style  face="normal" font="default" size="100%">Vasorelaxant effect</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">797-804</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Garcinia cowa Roxb. ex Choisy (G. cowa) is used in traditional medicine, both for improvement of blood circulation and indigestion, also as an antipyretic and expectorant. &lt;strong&gt;Objective:&lt;/strong&gt; This study investigated the vasorelaxant effects and possible mechanisms of action of G. cowa leaf ethanolic extract (GCE) on the rat isolated thoracic aorta. &lt;strong&gt;Methods:&lt;/strong&gt; The study examined the effects of GCE on isolated rat thoracic aorta, including both endothelium-intact and endothelium-denuded aortic rings, using an organ bath system. Specific inhibitors were used to evaluate the mechanism involved in GCE-induced vasorelaxation.&lt;strong&gt; Results:&lt;/strong&gt; GCE (0.01–10 mg/mL) relaxed endothelium-intact aortic rings, that had been precontracted with phenylephrine. Removal of the endothelium or pretreatment of endothelium-intact aortic rings with NꞶ-nitro-L-arginine methyl ester (L-NAME), or 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), significantly decreased vasorelaxation induced by the GCE. Indomethacin or propranolol had no effect on the GCE-induced relaxation of the endothelium-intact aortic rings. In endothelium-denuded aortic rings, the relaxation effect of GCE was significantly blocked by 4-aminopyridine (4-AP) and tetraethylammonium (TEA) at the maximum dose of GCE, but not by glibenclamide. In Ca&lt;sup&gt;2&lt;/sup&gt;+-free Krebs solution, GCE (5 and 10 mg/mL) significantly inhibited extracellular Ca&lt;sup&gt;2&lt;/sup&gt;+ induced contraction in pre-contracted rings with high KCl levels. &lt;strong&gt;Conclusions:&lt;/strong&gt; These findings suggest that GCE exhibits both an endothelium-dependent, which is mediated by an eNOS/NO/sGC pathway, and an endothelium-independent pathway, which involves KCa and KV channels opening and extracellular Ca&lt;sup&gt;2&lt;/sup&gt;+ influx inhibition. Kaempferol, isovitexin, quercetin, apigenin, luteolin, and amentoflavone might play a role in inducing the vasorelaxant effect of GCE.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">797</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siwaporn Praman*, Narudol Teerapattarakan, Thaneeya Hawiset &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;School of Medicine, Mae&amp;nbsp;Fah Luang University, Chiang Rai 57100, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Khairunnisa, Muhammad Faizi</style></author><author><style face="normal" font="default" size="100%">Nur Rochmah</style></author><author><style face="normal" font="default" size="100%">Yuni Hisbiyah</style></author><author><style face="normal" font="default" size="100%">Rayi Kurnia Perwitasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Girl with McCune-Albright Syndrome: Case Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">706-710</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;McCune-Albright syndrome (MAS) is a rare genetic disease characterized by skeletal, cutaneous, and endocrine system involvement. We report a 6-year-old girl with fibrous dysplasia, café-au-lait macula, and multiple hyperfunctional endocrinopathies. Treatment was palliative, the patient was planned for surgery on bilateral femur fractures and a rehabilitation program.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">706</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Khairunnisa, Muhammad Faizi*, Nur Rochmah,Yuni Hisbiyah, Rayi Kurnia Perwitasari&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anni Faridah</style></author><author><style face="normal" font="default" size="100%">Riski Gusri Utami</style></author><author><style face="normal" font="default" size="100%">Durain Parmanoan</style></author><author><style face="normal" font="default" size="100%">Risma Rahmatunisa</style></author><author><style face="normal" font="default" size="100%">Arif Adrian</style></author><author><style face="normal" font="default" size="100%">Ruhul Fitri Rosel4</style></author><author><style face="normal" font="default" size="100%">Nurul Huda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Global Research Landscape of Rendang: A Bibliometric Insight into Culinary Heritage and Innovation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bibliometric Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian Cuisine</style></keyword><keyword><style  face="normal" font="default" size="100%">Rendang</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1320-1330</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Rendang, a traditional Indonesian dish, has garnered international attention for its rich flavor and cultural significance. The study aimed to analyze the global research trends related to Rendang using bibliometric methods. By examining publications, citation patterns, and key areas of focus, we aim to provide insights into the scientific community's interest and the development of research on Rendang. The analysis utilized data from major academic databases, scopus.com. The search query keyword used was “Rendang” without restrictions on language, document type, or field of study. Visualization tools utilized include VOSviewer (version 1.16.18), and RStudio (Biblioshiny). A total of 63 documents were analyzed, revealing an annual growth rate of 3.06% and an average of 11.24 citations per document, with an international co-authorship rate of 9.524%. Indonesia and Malaysia emerged as the top-cited countries. The study recommends broadening Rendang research beyond descriptive studies to explore innovations in food processing, faster cooking methods, packaging, preservation, and health impacts. Further research should address sustainability, economic impacts, and increased international collaboration, aiming for more publications in high-impact journals. Additionally, the commercialization of ready-to-eat Rendang that preserves its traditional taste and the application of smart food technologies are essential for enhancing global research impact.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1320</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anni Faridah&lt;sup&gt;1*&lt;/sup&gt;, Riski Gusri Utami&lt;sup&gt;1&lt;/sup&gt;, Durain Parmanoan&lt;sup&gt;2&lt;/sup&gt;, Risma Rahmatunisa&lt;sup&gt;1&lt;/sup&gt;, Arif Adrian&lt;sup&gt;3&lt;/sup&gt;, Ruhul Fitri Rosel&lt;sup&gt;4&lt;/sup&gt;, Nurul Huda&lt;sup&gt;5,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Culinary Arts, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Mechanical Engineering, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Tourism, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Alumni of Technology and Vocational Education (PTK), Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Sustainable Agriculture, Universiti Malaysia Sabah, Sandakan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Adjunct Professor, Faculty of Fisheries and Marine Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Titut Harnanik</style></author><author><style face="normal" font="default" size="100%">Ketut Edy Sudiarta</style></author><author><style face="normal" font="default" size="100%">Rudi Pandapotan Napitupulu</style></author><author><style face="normal" font="default" size="100%">Arif Rahman Nurdianto</style></author><author><style face="normal" font="default" size="100%">Ni Ketut Alit Darmayanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hyperbaric Oxygen in Animal Model of Diabetes Nephropathy: Analysis of Blood Glucose, Proteinuria and Kidney Tissue Necrosis Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes Nephropaty</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperbaric Oxygen</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney Tissue Necrosis Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Proteinuria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1043-1046</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and is the main cause of 20 to 40 times higher mortality compared to diabetes without nephropathy. Therefore, the author wants to prove the effect of hyperbaric oxygen therapy (HBO) on changes in blood glucose levels, proteinuria and kidney tissue necrosis cells in DN animal models. This study used 27 male white rats Rattus Norvegicus strain Wistar, weighing 170 - 220 grams, aged 8-12 weeks, healthy and active, divided into 3 groups, namely the normal rats group (G0), the DN rats without HBO group (G1) and the DN rats with HBO group (G2). Making a DN model with Streptozotocin (STZ) induction 75 mg / kgBW intraperitoneally in a single dose. HBO was performed in a 2.4 ATA pressurized air chamber by inhaling 98% O2 for 3 x 30 minutes interspersed with inhaling normal air for 2 x 5 minutes for 5 consecutive days. The results showed a significant decrease in blood glucose levels p = 0.000 (p &amp;lt;0.05). In proteinuria levels, there was an insignificant decrease p = 0.077 (p &amp;gt; 0.05) in G2 compared to G1. Repair of kidney tissue damage was also indicated by a decrease in necrotic cells by 45.45% in G2 compared to G1. These results prove that HBO can repair kidney damage in DN model mice, so HBO is expected to be used as an additional therapy in cases of diabetic nephropathy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1043</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Titut Harnanik&lt;sup&gt;1,2,*&lt;/sup&gt;, Ketut Edy Sudiarta&lt;sup&gt;1&lt;/sup&gt;, Rudi Pandapotan Napitupulu&lt;sup&gt;1&lt;/sup&gt;, Arif Rahman Nurdianto&lt;sup&gt;1&lt;/sup&gt;, Ni Ketut Alit Darmayanti&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Marine Health, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Naval Health Institute Drs. Med. R. Rijadi S, Phys., Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Astrid Dewi Prabaningtyas</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">A Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Chatarina Umbul W</style></author><author><style face="normal" font="default" size="100%">Ummu Salmah</style></author><author><style face="normal" font="default" size="100%">Lalu Muh Saleh</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Implementation Model of Acceptance of Covid-19 Booster Vaccine in Elderly in Bogor City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acceptance of the COVID-19 Vaccine</style></keyword><keyword><style  face="normal" font="default" size="100%">Attitudes</style></keyword><keyword><style  face="normal" font="default" size="100%">Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Module</style></keyword><keyword><style  face="normal" font="default" size="100%">Peer group</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">145-149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The major impact of COVID-19 occurs especially on the elderly, however the vaccination achievement rate among them tends to be low. The COVID-19 vaccination strategy for the elderly must still be implemented even though WHO has been revoked the Public Health Emergency of International Concern (PHEIC) status for COVID-19. One approach that can be taken is to empower the elderly in the vaccination process. This research aims to see the effectiveness of changes in knowledge, attitudes and behavior of the elderly regarding acceptance of the COVID-19 vaccine after receiving educational intervention using modules using the peer group method. &lt;strong&gt;Method: &lt;/strong&gt;Quasi-experiment with a one-group pretest-posttest pattern. The research was conducted at the North Bogor Community Health Center in April-June 2023 on 66 elderly people taken using a purposive sampling technique. The questionnaire is used to look at characteristics, vaccine history, assess respondents' knowledge, attitudes and behavior regarding the COVID-19 situation. Data collection went through three stages, namely pre-test distribution, peer group method using module-19 and post-test distribution. Bivariate analysis with dependent t-test using SPSS 23.0 software.&lt;strong&gt; Results:&lt;/strong&gt; The majority of elderly people were aged 60-74 years (90.9%) and there was a significant increase (p&amp;lt;0.05) in the average score of knowledge, attitudes and behavior of elderly people before and after being given the intervention. The average knowledge score before intervention was 69.60 ± 9.51 and after intervention 80.30 ± 10.29, attitude score before intervention 80.43 ± 9.61 and after intervention 85.25 ± 11.99, and behavior score before intervention 86.29 ± 14.67 and after intervention 90.35 ± 10.34. &lt;strong&gt;Conclusion:&lt;/strong&gt; implementation of the model with intervention modules is effective in increasing knowledge, attitudes and behavior. It is hoped that with this increase, elderly people will be able to receive the COVID-19 vaccine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">145</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Astrid Dewi Prabaningtyas&lt;sup&gt;1&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, A Arsunan Arsin&lt;sup&gt;3&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;4&lt;/sup&gt;, Chatarina Umbul W&lt;sup&gt;5&lt;/sup&gt;, Ummu Salmah&lt;sup&gt;6&lt;/sup&gt;, Lalu Muh Saleh&lt;sup&gt;7&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;8&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D Candidate of Public Health Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Ph.D of Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor of Epidemiology, Faculty of Public Health, Airlangga University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor of Biostatistics and Population, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Professor of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Ph.D of Health Promotion and Behavior Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor of Environmental Health, Faculty of Public Health, Hasanuddin University INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Dheo Shalsabilla Novel</style></author><author><style face="normal" font="default" size="100%">Herland Satriawan</style></author><author><style face="normal" font="default" size="100%">Khang Wen Goh</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Sri Suwarni</style></author><author><style face="normal" font="default" size="100%">Ria Septiana</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Mochammad Aqilah Herdiansyah</style></author><author><style face="normal" font="default" size="100%">Anni Faridah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Gene Transcription of 4-Hydroxycinnamic Acid from Broccoli Fruit (Brassica oleracea var. italica) with Estrogen Receptor Beta Protein</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brassica oleracea var. italica</style></keyword><keyword><style  face="normal" font="default" size="100%">good health and well-being.</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular interaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">791-796</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;This study aims to explore the relationship between 4-Hydroxycinnamic Acid, a compound found in broccoli fruit (&lt;em&gt;Brassica oleracea &lt;/em&gt;var. &lt;em&gt;italica&lt;/em&gt;), and Estrogen Receptor Beta Protein through &lt;em&gt;in silico&lt;/em&gt; analysis. The research was conducted using Pymol, MOE 2015, Discovery Studio 2016, and Lepinski Rule software. These tools were employed to model the structure of both the compound and protein, as well as to evaluate their interaction. The results revealed a significant interaction with a Binding Affinity of -6.4182. Moreover, the Root Mean Square Deviation (RMSD) measurements yielded a value of 3.8907, indicating the degree of agreement between the compound and protein structures. Analysis using the Lepinski Rule disclosed the characteristics of the compound 4-Hydroxycinnamic Acid, including a mass of 164, two hydrogen bond donors, three hydrogen bond acceptors, a log P value of 1.490, and a molar reactivity of 44.776. These findings provide valuable insights into the potential of 4-Hydroxycinnamic Acid in interacting with Estrogen Receptor Beta Protein, which could serve as a foundation for further research on the health benefits and therapeutic applications of this compound, contributing to the goal of good health and well-being.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">791</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahadian Zainul&lt;sup&gt;1,2,3&lt;/sup&gt;*, Dheo Shalsabilla Novel&lt;sup&gt;1,2&lt;/sup&gt;, Herland Satriawan&lt;sup&gt;4&lt;/sup&gt;, Khang Wen Goh&lt;sup&gt;5&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8&lt;/sup&gt;, Sri Suwarni&lt;sup&gt;9&lt;/sup&gt;, Ria Septiana&lt;sup&gt;10&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;6,11,12,13&lt;/sup&gt;, Mochammad Aqilah Herdiansyah&lt;sup&gt;12,13,14&lt;/sup&gt;, Anni Faridah&lt;sup&gt;15,16&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;sup&gt;2&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Fellow, INTI International University, 71800, Nilai, Negeri Sembilan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Data Science and Information Technology, INTI International University, Nilai, MALAYSIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Bachelor of Pharmacy, Nusaputera College of Pharmacy Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Bachelor of Pharmacy, Kendal College of Health Kendal, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Postgraduate School, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Virtual Research Center for Bioinformatics and Biotechnology, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Division of Research and Development, Jalan Tengah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Halal Certification Division, Universitas Negeri Padang, Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Culinary Innovation Technology, Department of Family Welfare Science, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammed W. Shackori</style></author><author><style face="normal" font="default" size="100%">Ammar A. Qasim</style></author><author><style face="normal" font="default" size="100%">Nadia H. Hasan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An in Vitro Comparative Evaluation for Internal and Marginal Integrity and the Degree of Monomer Conversion of Alkasite Restorative Material</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkasite</style></keyword><keyword><style  face="normal" font="default" size="100%">Degree of Conversion</style></keyword><keyword><style  face="normal" font="default" size="100%">Marginal and Internal Adaptation</style></keyword><keyword><style  face="normal" font="default" size="100%">Micro-CT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">442-449</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; To compare and evaluate marginal and internal adaptation and to assess the degree of conversion of alkasite restoration in relation with other restorative materials. &lt;strong&gt;Methods:&lt;/strong&gt; on the buccal surface of 25 maxillary premolars a class V cavities were prepared. The teeth were randomly divided into five groups (n=5) that restored as: Group 1: alkasite without adhesive, Group 2: alkasite with adhesive, Group 3: Nanohybrid composite, Group 4: Glass ionomer cement, and Group 5: Resin modified glass ionomer cement. The teeth underwent 5000 cycles of thermocycling between 5° and 55°. Then, silver nitrate solution was infiltrated and Micro-Computed tomography analysis was performed using (LOTUS inVivo). For evaluating degree of conversion, 15 specimens in the form of a disc were prepared from Alkasite, nanohybrid composite and resin modified glass ionomer (n=5). All samples were analyzed using (FTIR) in an ATR Mode in three intervals (after 20 second. 24 hours and 7 days). The data had been analyzed using the Kruskal-Wallis, Dune and Wilcoxon tests at a 0.05 significance level. &lt;strong&gt;Result:&lt;/strong&gt; A significant difference in marginal and internal adaptation were observed among restorations (p &amp;lt; 0.05). Superior marginal and internal adaptation was obtained in this study for alkasite whether with or without bonded over nanohybrid composite. However, RMGIC and GIC show more adaptation values among other tested groups. Also degree of monomer conversion percentage varied among restorations at different intervals. &lt;strong&gt;Conclusion:&lt;/strong&gt; alkasite restorations wither with or without bonding have higher marginal and internal adaptation in comparison with nanohybrid composite but lower than that of GIC and RMGIC. Also alkasite restoration showed higher degree of conversion when compared with nanohybride composite and RMGIC after 20 second and 24 hours of polymerization&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">442</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohammed W. Shackori*, Ammar A. Qasim, Nadia H. Hasan&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Azizah</style></author><author><style face="normal" font="default" size="100%">Budi Santoso</style></author><author><style face="normal" font="default" size="100%">Abdurachman</style></author><author><style face="normal" font="default" size="100%">Hanik Badriyah Hidayati</style></author><author><style face="normal" font="default" size="100%">Ario Imandiri</style></author><author><style face="normal" font="default" size="100%">Rafhani Rosyidah</style></author><author><style face="normal" font="default" size="100%">Ratna Dwi Jayanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Increasing Oxytocin through Electroacupuncture Stimulation at LI4 and SP6 Points in Postpartum Cesarean Section</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Electroacupuncture</style></keyword><keyword><style  face="normal" font="default" size="100%">LI4</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxytocin</style></keyword><keyword><style  face="normal" font="default" size="100%">Postpartum</style></keyword><keyword><style  face="normal" font="default" size="100%">SP6</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1051-1055</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Pain from postoperative cesarean section stitches can cause physiological stress, thereby disrupting mobility and affecting the uterine involution process postpartum. Acupuncture at points LI4 and SP6 has been reported to stimulate uterine contractions and reduce pain. &lt;strong&gt;Objective:&lt;/strong&gt; To look into how electroacupuncture (EA) stimulation works at particular places LI4, SP6, and the combination of LI4 &amp;amp; SP6 with frequencies of 30, 50, and 100 Hz on the increase in oxytocin levels postpartum cesarean section. &lt;strong&gt;Method: &lt;/strong&gt;The number of respondents was 144 postpartum cesarean section patients who met the inclusion criteria, divided using the randomized controlled trial (RCT) method into 8 intervention and control groups. Oxytocin levels were analyzed through blood samples using the ELISA method, comparing results before and after the intervention as well as with the control group. &lt;strong&gt;Result:&lt;/strong&gt; The electroacupuncture intervention group's analysis at points LI4 and SP6 showed a substantial (P&amp;lt;0.05) rise in oxytocin levels when compared to the control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of this research suggest that electroacupuncture intervention following a cesarean section can induce a rise in the levels of the hormone oxytocin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1051</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurul Azizah&lt;sup&gt;1&lt;/sup&gt;, Budi Santoso&lt;sup&gt;2*&lt;/sup&gt;, Abdurachman&lt;sup&gt;2&lt;/sup&gt;, Hanik Badriyah Hidayati&lt;sup&gt;2&lt;/sup&gt;, Ario Imandiri&lt;sup&gt;3&lt;/sup&gt;, Rafhani Rosyidah&lt;sup&gt;4&lt;/sup&gt;, Ratna Dwi Jayanti&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science Faculty of Medicine, Airlangga University, Surabaya, Indonesia, and&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;H&lt;/sup&gt;ealth Science Faculty Muhammadiyah University of Sidoarjo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program of Medical Science Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Vocational Studies, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Health Science Faculty Muhammadiyah University of Sidoarjo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Midwifery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Zaeim Hafez Ahmed</style></author><author><style face="normal" font="default" size="100%">Muhammad Abdelbaeth Hassan Elfiky</style></author><author><style face="normal" font="default" size="100%">Elsayed Elagamy Elsayed Mohamed</style></author><author><style face="normal" font="default" size="100%">Ramadan Hassan Ibrahim Thabet</style></author><author><style face="normal" font="default" size="100%">Ahmed Mohamed Gad Allah</style></author><author><style face="normal" font="default" size="100%">Ahmed Abdrabo Elshenawy Elsisi</style></author><author><style face="normal" font="default" size="100%">Ahmed Abdel Nasser Ahmed Mohamed</style></author><author><style face="normal" font="default" size="100%">Tarek Shikhon</style></author><author><style face="normal" font="default" size="100%">Mostafa Abo-akrab</style></author><author><style face="normal" font="default" size="100%">Sayed A.M.Mahmoud</style></author><author><style face="normal" font="default" size="100%">Mohamed AbdelAziz Doma</style></author><author><style face="normal" font="default" size="100%">Wael Ahmed Mahmoud Khattab</style></author><author><style face="normal" font="default" size="100%">Khaled Saleh Ali Elhamaky</style></author><author><style face="normal" font="default" size="100%">Mohamed El- Salamoni</style></author><author><style face="normal" font="default" size="100%">Fatma Mahmoud Abdelraheem</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ahmad Mohamed Azab</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ahmad Mohamed Azab6</style></author><author><style face="normal" font="default" size="100%">Mohamed E EL-Refaey</style></author><author><style face="normal" font="default" size="100%">Ahmed A. Abd El-Rhman</style></author><author><style face="normal" font="default" size="100%">Ahmed F. Abdel Ghany</style></author><author><style face="normal" font="default" size="100%">Ghada Adel Hegazy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Chamomile Leaves extract in Different Doses on Renal Functions and Diabetic indices in Streptozotocin – Induced Diabetic Rat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chamomile leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1029-1035</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The prevalence of diabetes among Egyptians is rising. Therefore, there is always a demand for innovative natural medicines. Medicinal plants have long been a significant source in search of novel, effective alternatives for human therapy. Chamomile is one of the most widely used medicinal plants, which may help hyperglycemic patients by lowering blood sugar levels. Objectives: To determine how chamomile extract affects the kidneys when albino male rats with chronic diabetes are induced by streptozotocin (STZ). &lt;strong&gt;Methods:&lt;/strong&gt; The study was conducted in the Al-Azhar Faculty of Medicine (Assiut) pharmacology department animal laboratory. For this investigation, a local strain of fifty adult male albino rats was used as the animal model and weighed 120 to 150 g. In this study, rats were divided into five groups, body weight, and systolic blood pressure was measured, and blood samples were collected for measuring blood glucose and insulin level, HbA1c, Na, K, and renal function tests, and histopathological examination was done. &lt;strong&gt;Results:&lt;/strong&gt; After the study, mean glucose levels, HbA1c, urea, creatinine, K, and systolic blood pressure were significantly decreased in group IV &amp;amp; group V compared to group III. In contrast, body weight serum insulin level and Na increased dramatically in group IV &amp;amp; group V compared to group III.&lt;strong&gt; Conclusion:&lt;/strong&gt; The serum levels of urea and creatinine in diabetic patients may be positively affected by chamomile. Additionally, short-term chamomile uses benefits diabetic individuals by decreasing loss of body weight, lowering HbA1c, and increasing insulin levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1029</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohamed Zaeim Hafez Ahmed&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Abdelbaeth Hassan Elfiky&lt;sup&gt;1&lt;/sup&gt;, Elsayed Elagamy Elsayed Mohamed&lt;sup&gt;2&lt;/sup&gt;, Ramadan Hassan Ibrahim Thabet&lt;sup&gt;2&lt;/sup&gt;, Ahmed Mohamed Gad Allah&lt;sup&gt;3&lt;/sup&gt;, Ahmed Abdrabo Elshenawy Elsisi&lt;sup&gt;2&lt;/sup&gt;, Ahmed Abdel Nasser Ahmed Mohamed&lt;sup&gt;2&lt;/sup&gt;, Tarek Shikhon&lt;sup&gt;4&lt;/sup&gt;, Mostafa Abo-akrab4, Sayed A.M.Mahmoud&lt;sup&gt;5&lt;/sup&gt;, Mohamed AbdelAziz Doma&lt;sup&gt;5&lt;/sup&gt;, Wael Ahmed Mahmoud Khattab&lt;sup&gt;6&lt;/sup&gt;, Khaled Saleh Ali Elhamaky&lt;sup&gt;7&lt;/sup&gt;, Mohamed El-Salamoni&lt;sup&gt;6&lt;/sup&gt;, Fatma Mahmoud Abdelraheem&lt;sup&gt;8,&lt;/sup&gt; Mahmoud Ahmad Mohamed Azab&lt;sup&gt;6&lt;/sup&gt;, Ashraf Abdel Aty Elshenawy Emara&lt;sup&gt;6&lt;/sup&gt;, Mohamed E EL-Refaey&lt;sup&gt;1&lt;/sup&gt;, Ahmed A. Abd El-Rhman&lt;sup&gt;1&lt;/sup&gt;, Ahmed F. Abdel Ghany&lt;sup&gt;1&lt;/sup&gt;, Ghada Adel&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Al-Azhar University (Assiut), Assiut, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rachmi Hasjim</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Alwi Arifin</style></author><author><style face="normal" font="default" size="100%">Balqis</style></author><author><style face="normal" font="default" size="100%">Suriah</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Influence of Patient Satisfaction on the Loyalty of Inpatient Patients at Dr. Tadjuddin Chalid Hospital Makassar City Year 2023</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Image Hospital</style></keyword><keyword><style  face="normal" font="default" size="100%">Patient Loyalty</style></keyword><keyword><style  face="normal" font="default" size="100%">Patient Satisfaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Services Quality</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">436-441</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Patient satisfaction reflects the patient's attitude towards care consisting of emotions and perceptions of the health services provided to them, because patient satisfaction will influence patient loyalty. This research design was carried out with an analytical survey using a quantitative approach using cross sectional research, namely research carried out at the same time which aims to analyze and find out how service quality influences the level of patient satisfaction on patient loyalty. The sample in this study is the population of inpatients in 2022, namely 9,526 patients, the sampling was 276 patients, by calculating the sample size using the Lemeshow formula. The sampling technique used in this research uses the accidental sampling technique, namely a sampling technique based on chance, that is, anyone who meets the researcher by chance can be used as a sample.Based on the research results, there is a relationship between reliability and patient loyalty with statistical test results (p=0.000). Assurance has a significant relationship with patient loyalty and statistical test results (p=0.000), and empathy has a significant relationship with patient loyalty with statistical test results (p=0.000) . There is no significant relationship between physical evidence (tangible) on patient loyalty and statistical test results (p=1.000), responsiveness has no relationship on patient loyalty and statistical test results (p=0.698). Researchers' recommendations relate to patient satisfaction and patient loyalty at RSUP Dr. Tadjuddin Chalid Makassar City, to further improve the services needed by the community in general.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">436</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rachmi Hasjim&lt;sup&gt;1,*&lt;/sup&gt;, Darmawansyah&lt;sup&gt;2&lt;/sup&gt;, Alwi Arifin&lt;sup&gt;2&lt;/sup&gt;, Balqis&lt;sup&gt;2&lt;/sup&gt;, Suriah&lt;sup&gt;3&lt;/sup&gt;, Wahiduddin&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Student of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Health Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andi Muh. Maulana</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Erni Hernawati Purwaningsih</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Taifo Mahmud</style></author><author><style face="normal" font="default" size="100%">Heri Wibowo</style></author><author><style face="normal" font="default" size="100%">Bambang Pontjo Priosoeryanto</style></author><author><style face="normal" font="default" size="100%">Primariadewi Rustamadji</style></author><author><style face="normal" font="default" size="100%">Numlil Khaira Rusdi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Mechanisms of Soybean Extract on the Development of Breast Cancer Through Modulation of Cellular Immune Response</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">CD4+</style></keyword><keyword><style  face="normal" font="default" size="100%">CD8+</style></keyword><keyword><style  face="normal" font="default" size="100%">Cellular immune response</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">01-08</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Breast cancer is the most frequently diagnosed cancer in women worldwide. Consumption of soy products has been reported to reduce the incidence of and mortality rate for some cancers, including breast cancer. However, there are limited &lt;em&gt;in vivo&lt;/em&gt; studies on the inhibitory effect of soybean extracts on breast cancer. &lt;strong&gt;Objectives:&lt;/strong&gt; To examine the effect of soybean extracts on breast cancer cellular immunity and to determine the role of CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T cells in the development and outcome of breast cancer. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Rat were induced with DMBA 11 times to get a breast cancer model. A soybean extract was given at different doses starting one week before DMBA induction and continued until the end of the study. At the end of the study, peripheral blood was collected, and the lymphocytes were examined using flow cytometry. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening of soybean extract, using the Q-TOF LC/MS method, detected four bioactive components from the isoflavone and saponin groups. The incidence of tumor formation in the NeC, SE-D250, SE-D500, and SE-D1000 groups was 100%, 83%, 33%, and 33%, respectively. The highest proportion of CD4+ T cells was found in the NeC (69.35%), while the lowest was in the SE-D1000 (63.75%). The highest and lowest proportions of CD8+ T cells were found in the SE-D1000 and NeC groups, at 35.95% and 31.15%, respectively. &lt;strong&gt;Conclusions:&lt;/strong&gt; The soybean extract was able to reduce the incidence of breast tumor formation in DMBA-induced rat in a dose-dependent manner. The soy extract group's CD4+/CD8+ ratio was close to that of healthy rats compared to the DMBA-induced group without soy extract. A lowered CD4+/CD8+ ratio is followed by a lower risk of tumor formation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">01</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Andi Muh. Maulana&lt;sup&gt;1,2&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;1,3,4,5,&lt;/sup&gt;*, Erni Hernawati Purwaningsih&lt;sup&gt;1,4,6&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;1,7&lt;/sup&gt;, Taifo Mahmud&lt;sup&gt;8&lt;/sup&gt;, Heri Wibowo&lt;sup&gt;9&lt;/sup&gt;, Bambang Pontjo Priosoeryanto&lt;sup&gt;10&lt;/sup&gt;, Primariadewi Rustamadji&lt;sup&gt;3&lt;/sup&gt;, Numlil Khaira Rusdi&lt;sup&gt;11&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Purwokerto, Banyumas, Central Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Development Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Pharmaceutical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmaceutical Sciences, Oregon State University, 203 Pharmacy Building, Corvallis, Oregon 97331, UNITED STATES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Parasitology - Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Division of Veterinary Pathology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Risma Risma</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanti</style></author><author><style face="normal" font="default" size="100%">Syamsiar S.Russeng</style></author><author><style face="normal" font="default" size="100%">Apik Indarty</style></author><author><style face="normal" font="default" size="100%">Abdul Salam</style></author><author><style face="normal" font="default" size="100%">Toto Sudargo</style></author><author><style face="normal" font="default" size="100%">Abdul Fandir</style></author><author><style face="normal" font="default" size="100%">Masrif Masrif</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Intercorrelations among Hemoglobin Level, Physical Fitness, and Cognitive Score in Adolescent Girls: A Cross Sectional Study in Banggai District, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent girl</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin level</style></keyword><keyword><style  face="normal" font="default" size="100%">kognitif</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Fitness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">405-409</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Iron deficiency anemia in adolescent girls can cause decreased concentration, cognitive levels and fitness. In the long term it will have an impact on low productivity and school achievement. This study aims to analyze the correlations between hemoglobin level, physical fitness and cognitive score in Anemic adolescent girls. The research design was cross-sectional, with a sample of adolescent girls aged 12–18 years (n=139). Iron status was determined by hemoglobin levels using Hemocue. Cognitive function was measured using the Culture Fair Intelligence Test (CFIT), memory scores using the Intelligenz Structure Test (ITS), and physical fitness based on the predicted VO2max using the Bleep Test. Correlation analysis uses Pearson correlation analysis. The research results showed that overall 58.3% of students experienced anemia, of which 64.1% experienced mild anemia and 32.1% experienced moderate anemia. The average value of hemoglobin levels in respondents was 11.6 mg/dl. The mean predicted VO2 max is 25.3 kg/ m2 and kognitif score 81,02 and memori score 11,01. Pearson's test results showed that there was a significant positive correlation between hemoglobin levels and predicted VO2 max (r = 0.28, p&amp;lt;0.05) and memori score (r = 0.31, p&amp;lt;0.05). There was a weak correlation between hemoglobin levels and kognitif score (r=0.17, p=0.053). &lt;strong&gt;Conclusion:&lt;/strong&gt; There is a significant relationship between hemoglobin levels and physical fitness and cognitive function. Therefore, an intervention program is needed to increase Hb levels in adolescent girls&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Risma Risma&lt;sup&gt;1,*&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Andi Zulkifli&lt;sup&gt;3&lt;/sup&gt;, Healthy Hidayanti&lt;sup&gt;2&lt;/sup&gt;, Syamsiar S.Russeng&lt;sup&gt;4&lt;/sup&gt;, Apik Indarty&lt;sup&gt;5&lt;/sup&gt;, Abdul Salam&lt;sup&gt;2&lt;/sup&gt;, Toto Sudargo&lt;sup&gt;6&lt;/sup&gt;, Abdul Fandir&lt;sup&gt;2&lt;/sup&gt;, Masrif Masrif&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, School of Public Health, Hasanuddin University, Poltekkes Kemenkes Kendari, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Reproductive Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Poltekkes Kemenkes Jayapura, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ani Retno Prijanti</style></author><author><style face="normal" font="default" size="100%">Novi Silvia Hardiany</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Insights into Spirulina platensis Compounds Targeting TNFa and P21 in Delaying Cellular Senescence Mechanisms: An In Silico Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">p21 expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Spirulina platensis</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFa-induced cellular senescence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">809-815</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;Spirulina platensis with bioactive compounds such as Phycocyanin, β-carotene, Genistein and α-glucan, have been shown to have anti-inflammatory properties. Our present study investigation utilizes an in silico methodology to examine the molecular interactions between Spirulina platensis chemicals compound with TNFa and p21. Utilizing computational techniques molecular docking, our goal is to clarify the possible pathways by which Spirulina platensis chemicals could affect these important regulators and postpone cellular senescence. Our research may shed important light on the creation of Spirulina platensis-based therapies for ageing and age-related illnesses. Our results imply that Spirulina platensis may contribute to overall cellular health and the mitigation of cellular senescence. Phycocyanin has the most negative ΔG value is -15.0 kcal/mol. Genistein has the lowest Ki value, namely 7.299 μM. The ΔG and Ki values of Genistein were lower than Quercetin. The potential chemical interactions between substances generated from Spirulina platensis and senescence pathways, including those involving TNFa and p21, are highly intriguing for the development of innovative therapeutic approaches targeted at ameliorating cellular senescence dysfunction associated with aging.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">809</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;3*&lt;/sup&gt;, Ani Retno Prijanti&lt;sup&gt;4&lt;/sup&gt;, Novi Silvia Hardiany&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry Faculty of Medicine, UPN Veteran Jakarta, Jakarta, 12450, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Magister Program of Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kukuh Dwiputra Hernugrahanto</style></author><author><style face="normal" font="default" size="100%">Naufaldy Rifqiaulia Noerda</style></author><author><style face="normal" font="default" size="100%">Jifaldi Afrian Maharaja Dinda Sedar</style></author><author><style face="normal" font="default" size="100%">Lukas Widhiyanto</style></author><author><style face="normal" font="default" size="100%">Dwikora Novembri Utomo</style></author><author><style face="normal" font="default" size="100%">Djoko Santoso</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Cartilage-Derived Scaffolds for 3D Mesenchymal Stem Cell Culture: Promoting Chondrogenesis and Modulating Secretome Composition</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cartilage</style></keyword><keyword><style  face="normal" font="default" size="100%">Culture Technique</style></keyword><keyword><style  face="normal" font="default" size="100%">Secretome</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Three-Dimensional</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1365-1372</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The regenerative potential of stem cells lies in their secretome, a collection of signaling molecules whose composition is shaped by the cellular microenvironment and external stimuli. To enhance cartilage regeneration, a 3D culture system using a natural cartilage scaffold has been developed to create a more chondrogenic secretome. This study investigates the chondrogenic differentiation of mesenchymal stem cells (MSCs) cultured in a decellularized bovine cartilage scaffold and analyzes the resulting secretome's composition. &lt;strong&gt;Methods: &lt;/strong&gt;This study employed a randomized time series design to examine MSCs chondrogenic differentiation. A control group was cultured in standard 2D conditions, while two experimental groups were cultured in either 2D medium supplemented with chondrocyte differentiation medium (positive control) or a 3D decellularized bovine cartilage scaffold. The study hypothesized that the 3D culture would promote chondrogenesis at least as effectively as the positive control. Key chondrogenic markers were evaluated at various time points.&lt;strong&gt; Results: &lt;/strong&gt;Statistical analysis revealed significant differences in marker expression between the experimental and control groups. SOX-9 and aggrecan were elevated in both experimental groups. The 3D group showed higher RUNX-2 expression and the highest Coll-2 expression at later time points. Additionally, growth factor analysis showed the 3D group had the highest levels of IGF-1 and FGF-2 towards the end of the study. &lt;strong&gt;Conclusion: &lt;/strong&gt;3D culture of MSCs in a bovine cartilage scaffold enhances chondrogenic differentiation and produces a secretome with comparable chondrogenic potential to traditional 2D culture with differentiation medium, suggesting its promise for cartilage regeneration.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1365</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kukuh Dwiputra Hernugrahanto&lt;sup&gt;1,2,3&lt;/sup&gt;, Naufaldy Rifqiaulia Noerda&lt;sup&gt;4&lt;/sup&gt;, Jifaldi Afrian Maharaja Dinda Sedar&lt;sup&gt;2,3&lt;/sup&gt;, Lukas Widhiyanto&lt;sup&gt;2,3&lt;/sup&gt;, Dwikora Novembri Utomo&lt;sup&gt;2,3&lt;/sup&gt;, Djoko Santoso&lt;sup&gt;5,6*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Orthopaedic and Traumatology, Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Siti Khodijah Hospital, Sidoarjo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Internal Medicine, Dr Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Prafa Alif Rahmawan</style></author><author><style face="normal" font="default" size="100%">Yetti Hernaningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Compounds in Clot Waveform Analysis and D-Dimer Modulation: Implications for COVID-19 Diagnosis and Prognosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Activated partial thromboplastin time</style></keyword><keyword><style  face="normal" font="default" size="100%">Clot waveform analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">D-dimer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1373-1378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; Patients diagnosed with coronavirus disease (COVID-19) may develop hypercoagulopathy. A thromboelastogram can detect hypercoagulopathy, but it is not commonly available in all healthcare facilities. Understanding the clot waveform analysis (CWA) parameters of the CS-2500 coagulation analyzer in patients diagnosed with COVID-19 may help determine whether it can serve as an alternative. &lt;strong&gt;Methods:&lt;/strong&gt; This study measured the amounts of activated partial thromboplastin time (aPTT)-based CWA, aPTT, plasma prothrombin time (PPT), and D-dimer using the CS-2500 autoanalyzer in 177 patients confirmed with COVID-19 and 110 patients without COVID-19. Retrospective data collection was conducted using electronic medical records. COVID-19 and non-COVID-19 were distinguished by the SARS-COV-2 PCR results.&lt;strong&gt; Results: &lt;/strong&gt;Substantial differences were observed in the aPTT-based CWA parameters, including maximum coagulation velocity (Vmax), maximum coagulation acceleration (Amax), and maximum coagulation deceleration (Dmax) (p = 0.03, p = 0.03, and p = 0.02), between the COVID-19 and non-COVID-19 groups but not between survivors and non-survivors. Additionally, a substantial difference was identified in the D-dimer between the two groups (p = 0.002 and p &amp;lt; 0.001). The difference in D-dimer between both groups could be explained by the fact that non-survivors have a more prominent hypercoagulable state. &lt;strong&gt;Conclusions: &lt;/strong&gt;While the D-dimer may be a better indicator of mortality in COVID-19 patients, the aPTT-based CWA characteristics may be more helpful in differentiating between COVID-19 and non-COVID-19 patients. Further investigations on treatment interference and the specificity of this method to predict hypercoagulable states are warranted.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1373</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Prafa Alif Rahmawan&lt;sup&gt;1&lt;/sup&gt;, Yetti Hernaningsih&lt;sup&gt;2,3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Specialist, Clinical Pathology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yousra.A. Nomier</style></author><author><style face="normal" font="default" size="100%">Anugeetha Thacheril Mohanan</style></author><author><style face="normal" font="default" size="100%">Walaa A. El-Dakroury</style></author><author><style face="normal" font="default" size="100%">Dallin A. Hassan</style></author><author><style face="normal" font="default" size="100%">Sermugapandian Nithya</style></author><author><style face="normal" font="default" size="100%">Aamena Jabeen</style></author><author><style face="normal" font="default" size="100%">Eman Merghani Ali Mohammed</style></author><author><style face="normal" font="default" size="100%">Moataz B. Zewail</style></author><author><style face="normal" font="default" size="100%">Gihan F. Asaad</style></author><author><style face="normal" font="default" size="100%">Zeinah Y. Abbady</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Overview of Cancer and Treatment Challenges: Harnessing the Anti-cancer Potential of Jasminum Sambac and its Nanoparticle Formulations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Jasminum Sambac</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1069-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Cancer research strives to discover effective treatment strategies that target tumour cells while minimising the negative effects of traditional chemotherapy. Studies conducted on plant-based leads have yielded promising therapeutic activities, prompting researchers to remain vigilant in exploring further plant-based studies. Research has shown that phytochemicals found in the roots, leaves, and flowers of Jasminum sambac &lt;em&gt;(J.sambac&lt;/em&gt;) have demonstrated various active functions, including anti-inflammatory, antimicrobial, immunomodulatory, and anxiolytic effects. The progress made in nanoparticle drug delivery systems for cancer treatment is noteworthy as it allows for higher doses of medication to be delivered directly to cancer cells while minimising the negative impact on healthy cells. Various reports showcase the nanoparticle synthesis of &lt;em&gt;J.sambac&lt;/em&gt; for screening multiple diseases. This review provides an overview of cancer and the challenges of available treatments while exploring the potential of &lt;em&gt;J.sambac&lt;/em&gt; for its anticancer, cytotoxic, and antioxidant properties. Furthermore, it sheds light on the recent advances made in nanoparticle formulations of Jasminum sambac for cancer and other ailments. Disseminating these updates could encourage additional exploration into the potential anti-cancer properties of&lt;em&gt; J.sambac &lt;/em&gt;and foster the development of nanoparticles for more effective cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1069</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yousra.A. Nomier&lt;sup&gt;1*&lt;/sup&gt;, Anugeetha Thacheril Mohanan&lt;sup&gt;2 &lt;/sup&gt;*, Walaa A. El-Dakroury&lt;sup&gt;3&lt;/sup&gt;, Dallin A. Hassan&lt;sup&gt;2&lt;/sup&gt;,&amp;nbsp;Sermugapandian Nithya&lt;sup&gt;4&lt;/sup&gt;, Aamena Jabeen&lt;sup&gt;5&lt;/sup&gt;, Eman Merghani Ali Mohammed&lt;sup&gt;6&lt;/sup&gt;,&amp;nbsp;Moataz B. Zewail&lt;sup&gt;3&lt;/sup&gt;, Gihan F. Asaad&lt;sup&gt;7&lt;/sup&gt; , Zeinah Y. Abbady&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology and Clinical Pharmacy Department, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OMAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology and Toxicology Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER) (DU), Porur, Chennai 116, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmaceutics Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Clinical Practice Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Pharmacology Department, Medical Division, National Research Centre (ID: 60014618), Dokki, Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Pharmacy College, German University, Cairo, EGYPT&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman Herman</style></author><author><style face="normal" font="default" size="100%">Arsyik Ibrahim</style></author><author><style face="normal" font="default" size="100%">Junaidin Junaidin</style></author><author><style face="normal" font="default" size="100%">M. Arifuddin</style></author><author><style face="normal" font="default" size="100%">Baso Didik Hikmawan</style></author><author><style face="normal" font="default" size="100%">Siska Siska</style></author><author><style face="normal" font="default" size="100%">Tahyatul Bariroh</style></author><author><style face="normal" font="default" size="100%">Reza Yuridian Purwoko</style></author><author><style face="normal" font="default" size="100%">Lizma Febrina</style></author><author><style face="normal" font="default" size="100%">Muhammad Faisal</style></author><author><style face="normal" font="default" size="100%">Iswahyudi Iswahyudi</style></author><author><style face="normal" font="default" size="100%">Marissa Angelina</style></author><author><style face="normal" font="default" size="100%">Erwin Samsul</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile and Antidiabetic Activity of Eleutherine bulbosa Mills. Bulbs from East Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bawang Dayak</style></keyword><keyword><style  face="normal" font="default" size="100%">contaminant levels evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Eleutherine bulbosa (Mill.) Urb</style></keyword><keyword><style  face="normal" font="default" size="100%">pharmacognostic profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">118-125</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Eleutherine bulbosa (Mill.) Urb., known as Bawang Dayak, is commonly found growing in Kalimantan, Indonesia. The characteristics of the environment in which the plant grows greatly influence the characteristics of the plant and its biological activity. Objective: This study aimed to determine the pharmacognostic profile and evaluate the antidiabetic activity of E. bulbosa bulb extract obtained from Kota Bangun, Kutai Kertanegara, Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; The dried powdered of E. bulbosa bulbs was extracted using two different methods (maceration and microwave-assisted extraction). The evaluation of the sample fluorescence and non-specific parameters was done. The antidiabetic activity of the extracts was conducted using streptozocin-induced mice and histopathology analysis. &lt;strong&gt;Results:&lt;/strong&gt; The fluorescence evaluation indicated various secondary metabolites contained in E. bulbosa simplicia. Non-specific parameters include drying loss (8.83±0.2611%), water content in simplicia (8.04±0.7481%), specific gravity (1.04±0.0058%), total ash content (20.3±0.1583%), acid insoluble ash content (1.70±0.0608%), ethanol content in extract (0.99±0.0017%), lead content (0.010 mg/g), cadmium (0.091 mg/g), Arsenic (0.0003 mg/g), aflatoxin (not detected), and mold/yeast (0.8 × 105 colonies/g) meet the established regulations. Meanwhile, the antidiabetic assay showed that both extracts decreased the blood glucose levels in mice during the 14 days of treatments in a dose-dependent manner. This activity is correlated with the increased repair of pancreatic beta cells as observed by histopathological analysis. &lt;strong&gt;Conclusion:&lt;/strong&gt; The dried bulbs of E. bulbosa obtained from Kota Bangun, Kutai Kertanegara, East Kalimantan, Indonesia meet the standards set as raw materials for antidiabetic herbal medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">118</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman Herman&lt;sup&gt;1&lt;/sup&gt;, Arsyik Ibrahim&lt;sup&gt;1&lt;/sup&gt;, Junaidin Junaidin&lt;sup&gt;1&lt;/sup&gt;, M. Arifuddin&lt;sup&gt;1&lt;/sup&gt;, Baso Didik Hikmawan&lt;sup&gt;1&lt;/sup&gt;, Siska Siska&lt;sup&gt;3&lt;/sup&gt;, Tahyatul Bariroh&lt;sup&gt;4&lt;/sup&gt;, Reza Yuridian Purwoko&lt;sup&gt;5&lt;/sup&gt;, Lizma Febrina&lt;sup&gt;1&lt;/sup&gt;, Muhammad Faisal&lt;sup&gt;1&lt;/sup&gt;, Iswahyudi Iswahyudi&lt;sup&gt;2&lt;/sup&gt;, Marissa Angelina&lt;sup&gt;6&lt;/sup&gt;, Erwin Samsul&lt;sup&gt;1&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Cibinong, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kompleks Puspitek Serpong, South Tangerang and 15416, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Anam Al Arif</style></author><author><style face="normal" font="default" size="100%">Sunaryo Hadi Warsito</style></author><author><style face="normal" font="default" size="100%">Mirni Lamid</style></author><author><style face="normal" font="default" size="100%">Widya Paramita Lokapirnasari</style></author><author><style face="normal" font="default" size="100%">Aswin Rafif Khairullah</style></author><author><style face="normal" font="default" size="100%">Siti Rani Ayuti</style></author><author><style face="normal" font="default" size="100%">Sugito</style></author><author><style face="normal" font="default" size="100%">Intan Permatasari Hermawan</style></author><author><style face="normal" font="default" size="100%">Oky Setyo Widodo</style></author><author><style face="normal" font="default" size="100%">Rakhi Gangil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis of Curry Leaf Extract (Murraya koenigii L.) as a Potential Animal Feed and Medicinal Ingredient</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curry leaf extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Human health</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">471-477</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Herbal plants have been used for centuries as traditional medicine to treat various diseases. Green plants generally contain phytochemical compounds, such as vegetables and plants that add aroma to dishes, one of which is curry leaves (Murraya Koenigii). This research aims to identify the phytochemical compounds contained in curry leaves. This research was carried out from August 2023 to October 2023. The curry leaves that were obtained were converted into extract form and then the extract was tested for the content of alkaloids, flavonoids, saponins, phenolics and tannins. The research results showed that curry leaf extract contained 23.73% alkaloids, 1.24% flavonoids, 8.74% saponins, 4.4% phenolics, and 5.2% tannins. Alkaloids in plants have a role as a defense against biotic and abiotic disorders. The benefits of flavonoids in plants include anti-mutagenic, anti-inflammatory, antioxidant and anti-carcinogenic. Saponins have various benefits in the health sector, including being able to reduce cholesterol concentrations in the blood. Polyphenols have good antioxidant power because this group can provide electrons to neutralize free radical electrons formed in the body. Tannins also consist of polyphenolic compounds which have antibacterial, antioxidant and astringent activities. The results of the analysis regarding the content of secondary metabolite compounds in curry leaf extract play an important role in the development of future medicines and need to be carried out to provide knowledge to the public. This study can be a basis for bioactive content for further research to expand the use of medicinal plants in the future, especially curry plants.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">471</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohammad Anam Al Arif&lt;sup&gt;1&lt;/sup&gt;, Sunaryo Hadi Warsito&lt;sup&gt;1&lt;/sup&gt;, Mirni Lamid&lt;sup&gt;1*&lt;/sup&gt;, Widya Paramita Lokapirnasari&lt;sup&gt;1&lt;/sup&gt;, Aswin Rafif Khairullah&lt;sup&gt;2&lt;/sup&gt;, Siti Rani Ayuti3, Sugito&lt;sup&gt;3&lt;/sup&gt;, Intan Permatasari Hermawan&lt;sup&gt;4&lt;/sup&gt;, Oky Setyo Widodo&lt;sup&gt;1,5&lt;/sup&gt;, Rakhi Gangil&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Veterinary Science, National Research and Innovation Agency, Bogor, INDONESIA&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Veterinary Medicine, Universitas Syiah Kuala, Aceh, INDONESIA&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Veterinary Medicine, Universitas Wijaya Kusuma, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Theriogenology Joint Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Yamaguchi University, Yamaguchi, JAPAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Veterinary Microbiology, College of Veterinary Science and AH MHOW, Nanaji Deshmukh Veterinary University Jabalpur, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Gusti Agung Ayu Eka Putri Sunari</style></author><author><style face="normal" font="default" size="100%">Aryati Aryati</style></author><author><style face="normal" font="default" size="100%">Faradila Khoirun Nisa Hakim</style></author><author><style face="normal" font="default" size="100%">May Fanny Tanzilia</style></author><author><style face="normal" font="default" size="100%">Ida Parwati</style></author><author><style face="normal" font="default" size="100%">Rismawati Yaswir</style></author><author><style face="normal" font="default" size="100%">Budi Mulyono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Positive NS1 Antigen in Non-Dengue Virus Infection Serum: Possible Reasons for the Discrepancy with DENV PCR Results</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dengue Virus Infection.</style></keyword><keyword><style  face="normal" font="default" size="100%">NS1Ag</style></keyword><keyword><style  face="normal" font="default" size="100%">RT-PCR DENV</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">923-926</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objective: &lt;/strong&gt;A specific examination is required to distinguish between DVI and viral, bacterial, and parasitic illnesses because their clinical manifestations are nearly identical. Leukopenia and lymphocytosis are examples of non-specific tests that might be used to get a diagnosis. Non-structural protein 1 (NS1) antigen, anti-DENV antibody, or DENV-specific nucleic acid detection are more specific assays. &lt;strong&gt;Methods:&lt;/strong&gt; Virus isolation or molecular analysis of the detection of DENV nucleic acid ribonucleic acid (RNA) using RT-PCR was used to make the conclusive diagnosis of DVI. The sensitivity of the DENV RT-PCR method ranges from 28.8 to 99%. NS1 antigen is used as an initial diagnostic option in primary health care because it has a high specificity value (100%). Researchers want to analyze the positivity in non-DVI samples that have been confirmed by real-time RT-PCR examination with semi-quantitative NS1 antigen examination. Patient population aged 1-65 years with acute fever &amp;lt;5 days. A total of 130 samples of non-DVI confirmed patients by RT-PCR were examined for NS1Antigen ELISA. &lt;strong&gt;Results: &lt;/strong&gt;With a proportion of 3.08% of the total sample, the results showed that 4 NS1Antigen ELISA samples were positive. A negative DENV RT-PCR result could indicate either a true negative or a false negative. &lt;strong&gt;Conclusion: &lt;/strong&gt;The type of PCR technology, the primer used, the existence or absence of a DENV mutation, the DENV serotype, and the presence of mismatched nucleotides can all affect variations in DENV PCR sensitivity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">923</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;I Gusti Agung Ayu Eka Putri Sunari&lt;sup&gt;1&lt;/sup&gt;, Aryati Aryati&lt;sup&gt;1*&lt;/sup&gt;, Faradila Khoirun Nisa Hakim&lt;sup&gt;2&lt;/sup&gt;, May Fanny Tanzilia&lt;sup&gt;3&lt;/sup&gt;, Ida Parwati&lt;sup&gt;4&lt;/sup&gt;, Rismawati Yaswir&lt;sup&gt;5&lt;/sup&gt;, Budi Mulyono&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Airlangga – Dr. Soetomo Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Ciputra, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, IINDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Clinical Pathology, Faculty of Medicine,&amp;nbsp;Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Clinical Pathology and Laboratory Medicine, Faculty of Medicine, Public Health and Nursing,&amp;nbsp;Universitas Gadjah Mada - Dr. Sardjito General Hospital, Yogyakarta, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thigita Aga Pandaleke</style></author><author><style face="normal" font="default" size="100%">Kusworini Handono</style></author><author><style face="normal" font="default" size="100%">Dhelya Widasmara</style></author><author><style face="normal" font="default" size="100%">Hani Susianti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential of Orthosiphon Aristatus Extract in Improving Skin Lesions in Atopic Dermatitis: A Mice Model Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atopic dermatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Orthosiphon aristatus</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin lesions</style></keyword><keyword><style  face="normal" font="default" size="100%">Th2 cytokines</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">342-347</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; This research discusses the potential of Orthosiphon aristatus, a medicinal plant, in improving skin lesions in Atopic Dermatitis by regulating Th2 cytokines and showing anti-allergic activity. &lt;strong&gt;Methods:&lt;/strong&gt; The study was conducted using BALB/C mice induced with DNCB for 21 days to create an atopic dermatitis model. Then, the mice were orally administered Orthosiphon aristatus extract for 14 days (after 7 days of induction). The doses given were divided into six groups: 17.5 mg/kgbw, 35 mg/kgbw, 70 mg/kgbw, and 140 mg/kgbw. Molecular levels such as IgE, IL4, IL22, and PGE2 were analyzed from blood samples. In addition, the severity of skin lesions was assessed morphologically, and histological examination was performed to confirm clinical improvement. &lt;strong&gt;Results: &lt;/strong&gt;This study showed that the administration of Orthosiphon aristatus extract reduced the severity of skin lesions in all intervention groups. Histologically, this extract reduced epidermal thickness and mast cell infiltration. These findings were also supported by dose-dependent decreases in IgE, IL4, IL22, and PGE2 levels. So, the conclusion of this study is that Orthosiphon aristatus extract shows potential for improving skin lesions in atopic dermatitis by regulating Th2 cytokines and demonstrating anti-allergic activity in a mice model with DNCBinduced atopic dermatitis.&lt;strong&gt; Conclusion:&amp;nbsp;&lt;/strong&gt;The administration of Orthosiphon aristatus extract clinically and histologically exhibits anti-atopic effects that can be explained through the regulation of molecules such as IgE, IL4, IL22, PGE2, and NO. Orthosiphon aristatus has the potential to be a valuable herbal therapy for managing atopic dermatitis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">342</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thigita Aga Pandaleke&lt;sup&gt;1,2,*&lt;/sup&gt;, Kusworini Handono&lt;sup&gt;3&lt;/sup&gt;, Dhelya Widasmara&lt;sup&gt;4&lt;/sup&gt;, Hani Susianti&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Medical Sciences, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of medicine, Sam Ratulangi University - RD Kandou Hospital, Manado, North Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of medicine, Brawijaya University - Saiful Anwar Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of medicine, Brawijaya University - Saiful Anwar Malang, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Fajar Utami</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Hayun Hayun</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantification of Active Compounds from Coffea canephora Pierre ex A.Froehner cascara and their Potential Against MCF-7 and HeLa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cascara</style></keyword><keyword><style  face="normal" font="default" size="100%">Coffea canephora</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Isolation</style></keyword><keyword><style  face="normal" font="default" size="100%">servical cancer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">509-518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The utilization of coffee cascara, a byproduct of coffee cultivation, in cancer therapy research. This research begins with the rationale of exploring medicinal plants, especially coffee, to obtain compounds that can target cancer cells with fewer side effects. &lt;strong&gt;Objectivity: &lt;/strong&gt;This research aims to extract and evaluate the secondary metabolites from robusta coffee cascara, such as friedelin, lupeol, stigmasterol, ursolic acid, caffeine, chlorogenic acid, caffeic acid, and catechin, for their cytotoxic activity against Hela and MCF-7 cells. The aim of this research is also to identify and understand the cytotoxic mechanisms of compounds like stigmasterol, which showed significant cytotoxicity against cancer cells, paving the way for developing targeted cancer therapies from natural sources. &lt;strong&gt;Methods:&lt;/strong&gt; Robusta coffee cascara then goes to the process of extraction using ethanol, fractionation, isolation, purification, and characterization, followed by bioactivity evaluation using in vitro method through breast cancer cell line MCF-7 and cervical cancer cell line HeLa and determination of active compound levels. &lt;strong&gt;Results:&lt;/strong&gt; The cascara, a byproduct of coffee cultivation, is rich in proteins, polysaccharides, and bioactive compounds. Through extraction and purification processes, eight compounds were isolated and characterized, including &lt;strong&gt;(1)&lt;/strong&gt; friedelin, &lt;strong&gt;(2)&lt;/strong&gt; lupeol,&lt;strong&gt; (3)&lt;/strong&gt; Stigmasterol, &lt;strong&gt;(4)&lt;/strong&gt; Ursolic acid, &lt;strong&gt;(5)&lt;/strong&gt; caffeine, &lt;strong&gt;(6)&lt;/strong&gt; Chlorogenic acid, &lt;strong&gt;(7)&lt;/strong&gt; caffeic acid, and &lt;strong&gt;(8)&lt;/strong&gt; catechin. Bioactivity evaluation shows that stigmasterol (3) is the most cytotoxic compound with a value against Hela cells with an IC50 value of 25.85 μg/mL in the toxic category and against MCF-7 cells with an IC50 value of 12.83 μg/mL in the very toxic category. The results of determining the levels of active compounds in robusta coffee cascara extract showed that friedelin &lt;strong&gt;(1)&lt;/strong&gt; 0.539±0.137%; lupeol &lt;strong&gt;(2)&lt;/strong&gt; levels were 0.087±0.015%; &lt;strong&gt;(3)&lt;/strong&gt; stigmasterol 0.126±0.046%; ursolic acid &lt;strong&gt;(4)&lt;/strong&gt; 0.627±0.002%; caffeine &lt;strong&gt;(5) &lt;/strong&gt;3,203±0.069%; chlorogenic acid &lt;strong&gt;(6)&lt;/strong&gt; 0.679±0.003%; caffeic acid &lt;strong&gt;(7) &lt;/strong&gt;0.153±0.003% and catechin &lt;strong&gt;(8)&lt;/strong&gt; 0.3590.012% mg/g extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The research on robusta coffee cascara extract as a potential source of anticancer compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">509</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Fajar Utami&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;*, Hayun Hayun&lt;sup&gt;3&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;4,5,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Phytochemistry and Pharmacognosy, Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Math and Science, Universitas Pakuan, Jl. Raya Pakuan 1 Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Junjungan Kristianto Manurung</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Hamzah Hamzah</style></author><author><style face="normal" font="default" size="100%">Prihatma Kriswidyatomo</style></author><author><style face="normal" font="default" size="100%">Anggraini Dwi Sensusiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Relationship Between Blood Levels of Ubiquitin Carboxyterminal Hydrolase L1 (UCH-L1) Protein and the Severity of Traumatic Brain Injury Based on the Glasgow Coma Scale and Rotterdam CT Score</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Glasgow Coma Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Rotterdam CT score</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword><keyword><style  face="normal" font="default" size="100%">UCH-L1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">695-699</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Traumatic brain injury (TBI) is a leading cause of disability and death worldwide, with an estimated 64-74 million cases annually. The current gold standard for diagnosis is a computed tomography (CT) scan, which has limitations such as access, cost, and radiation risk. Therefore, a simple, accessible, and safe diagnostic modality is needed, one of which is biomarker examination. This study aims to establish the relationship between blood levels of the biomarker ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1) and the severity of TBI based on the Glasgow Coma Scale (GCS) and Rotterdam CT score. &lt;strong&gt;Material and Methods: &lt;/strong&gt;This observational analytic study with a cross-sectional design involved 41 samples aged 18-50 years who presented to the Emergency Department of Dr. Soetomo General Hospital, Surabaya, within 3-24 hours of the incident. UCH-L1 levels were measured from blood samples using the ELISA method, and the data on UCH-L1, GCS, and Rotterdam CT scores were analyzed with SPSS 29. &lt;strong&gt;Results:&lt;/strong&gt; The mean UCH-L1 level was 0.522 ± 0.592, with a cutoff value of &amp;gt; 0.2057, indicating moderate to severe TBI if UCH-L1 levels exceeded 0.2057. Spearman's test and correlation coefficient analysis showed a strong relationship between UCH-L1 levels and Rotterdam CT score (p &amp;lt; 0.05), as well as between UCH-L1 levels and TBI severity based on GCS (p &amp;lt; 0.05). The cutoff value for Rotterdam CT score was &amp;gt; 2, indicating moderate to severe TBI if the score exceeded 2. &lt;strong&gt;Conclusion:&lt;/strong&gt; Serum UCH-L1 levels are significantly associated with the severity of TBI based on GCS and Rotterdam CT score.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">695</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Junjungan Kristianto Manurung&lt;sup&gt;1&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1&lt;/sup&gt;*, Hamzah Hamzah&lt;sup&gt;1&lt;/sup&gt;, Prihatma Kriswidyatomo&lt;sup&gt;1&lt;/sup&gt;, Anggraini Dwi Sensusiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Radiology, Faculty of Medicine, Universitas Airlangga – Airlangga University Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Public Health &amp;amp; Preventive Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Henu Hadiyantama</style></author><author><style face="normal" font="default" size="100%">Lukisiari Agustini</style></author><author><style face="normal" font="default" size="100%">Sutjipto</style></author><author><style face="normal" font="default" size="100%">Evelyn Komaratih</style></author><author><style face="normal" font="default" size="100%">Ismi Zuhria</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author><author><style face="normal" font="default" size="100%">Ridholia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Role of α-SMA, Type 1 Collagen, and Myofibroblasts in Cicatrizing Conjunctivitis by Alkali Chemical Trauma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cicatrizing conjunctivitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Myofibroblasts</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 1 collagen</style></keyword><keyword><style  face="normal" font="default" size="100%">α -SMA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">591-596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Chemical trauma to the eye is a serious condition in the field of ophthalmology and a leading factor contributing to global blindness. Cicatrizing conjunctivitis (CC) is a term used to describe conditions marked by inflammation and the formation of scars on the conjunctiva. CC can have various causes, with one of them being chemical injury to the eye. The development of CC involves the participation of several cytokines and cells, such as α-SMA, Type 1 collagen, and Myofibroblasts. Myofibroblasts have the ability to contract through the utilization of diverse cytoskeletal proteins, which are commonly present in smooth muscle cells, including α-SMA. Actin filaments contribute to mechanically supporting cells, defining cell morphology, and facilitating cell mobility. Actin, in conjunction with myosin, participates in the muscle contraction process within muscle cells. Subsequently, type 1 collagen contributes to the healing of conjunctival wounds by providing a tensile force that aids in the closure of such wounds. As a significant constituent of the extracellular matrix, type 1 collagen plays a crucial role in maintaining the integrity of tissues.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Henu Hadiyantama&lt;sup&gt;1&lt;/sup&gt;, Lukisiari Agustini&lt;sup&gt;1*&lt;/sup&gt;, Sutjipto&lt;sup&gt;1&lt;/sup&gt;, Evelyn Komaratih&lt;sup&gt;1&lt;/sup&gt;, Ismi Zuhria&lt;sup&gt;1&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;2&lt;/sup&gt;, Ridholia&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA. 3Department of Pathology Anatomy, Faculty of Medicine/Dr. Soetomo General Academic Hospital, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">I Made Subhawa Harsa</style></author><author><style face="normal" font="default" size="100%">Andiani</style></author><author><style face="normal" font="default" size="100%">Sulistiawati</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Hanik Badriyah Hidayati</style></author><author><style face="normal" font="default" size="100%">Kuntaman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">SCN9A and SCN10A Polymorphism and Therapeutic Effectiveness of Lidocaine Local Anesthetic Injection in Subjects with Diabetic Neuropathy Pain</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic neuropathy pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Nav1.7</style></keyword><keyword><style  face="normal" font="default" size="100%">Nav1.8</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1259-1263</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetic neuropathy pain (DNP) is one of the complications experienced by more than half of the diabetic population. Treatment using lidocaine injection is one of the effective ways to manage pain in patients with DNP. Pain therapy using lidocaine locally targets the SCN9A and SCN10A genes, which encode the sodium receptors Nav1.7 and Nav1.8. The effect of lidocaine inhibits these sodium channels to reduce pain transmission. &lt;strong&gt;Purpose:&lt;/strong&gt; This study aims to analyze the effect of polymorphism of genes encoding Nav1.7 and Nav1.8 on the effectiveness of lidocaine local injection therapy in patients with DNP. &lt;strong&gt;Methods:&lt;/strong&gt; This study was an analytic observational study with a cross-sectional approach. A total of 63 people with DNP were genotyped for the SCN9A rs 6746030 gene and the SCN10A rs12632942 gene using Real-Time PCR/qPCR and DNA sequencing. &lt;strong&gt;Result: &lt;/strong&gt;The results showed that 91.2% and 70.6% of the population who experienced decreased pain had the GA mutant allele in the SCN9A rs6746030 gene and the AG mutant allele in the SCN10A rs12632942 gene. The results showed a significant association of Nav1.7 and Nav1.8 gene polymorphisms with the effectiveness of lidocaine local anesthetic injection therapy in diabetic neuropathy pain patients (p &amp;lt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study shows that there was an association between Nav1.7 and Nav1.8 gene polymorphisms and the effectiveness of lidocaine local anesthetic injection therapy in patients with DNP. Lidocaine injection therapy that targets the Nav1.7 and Nav1.8 sodium channels involving the SCN9A and SCN10A genes can be a therapeutic alternative for patients with DNP.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;I Made Subhawa Harsa&lt;sup&gt;1,2&lt;/sup&gt;, Andiani&lt;sup&gt;1,3&lt;/sup&gt;, Sulistiawati&lt;sup&gt;4*&lt;/sup&gt;, Lilik Herawati&lt;sup&gt;5&lt;/sup&gt;, Hanik Badriyah Hidayati&lt;sup&gt;6&lt;/sup&gt;, Kuntaman&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Wijaya Kusuma Surabaya University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Wijaya Kusuma Surabaya University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Wijaya Kusuma Surabaya University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Intanri Kurniati</style></author><author><style face="normal" font="default" size="100%">Agustyas Tjiptaningrum</style></author><author><style face="normal" font="default" size="100%">Raja Iqbal Mulya Harahap</style></author><author><style face="normal" font="default" size="100%">Bayu Putra Danan Jaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Serum Trace Element Levels in Type 2 DM Patients and its Correlation with Glycemic Control</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">glycemic control</style></keyword><keyword><style  face="normal" font="default" size="100%">HbA1c</style></keyword><keyword><style  face="normal" font="default" size="100%">trace element serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 diabetes mellitus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">660-663</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Type 2 diabetes mellitus, a chronic metabolic disorder, is known to impact serum trace element levels. Objectives: to investigates the association between serum trace elements (Co, Cr, and Cu) and glycemic control in individuals with type 2 diabetes. &lt;strong&gt;Material and Methods:&lt;/strong&gt; A 209 type 2 diabetes patients from Dr. H. Abdul Moeloek Hospital in Bandar Lampung and Hasan Sadikin Hospital in Bandung participated in the study. Patients underwent assessments for serum trace element levels (Co, Cr, and Cu) and glycemic control indicators (FBG and HbA1c). &lt;strong&gt;Results:&lt;/strong&gt; Results indicated significantly lower Co levels in uncontrolled diabetes versus controlled cases (P&amp;lt;0.05). Co, Cr, and Cu levels displayed a significant negative correlation with HbA1c (P&amp;lt;0.05), while Cr and Cu showed a significant negative correlation with FBG (P&amp;lt;0.05). Age did not show significant correlations with serum trace element levels. &lt;strong&gt;Conclusion:&lt;/strong&gt; serum trace element levels (Co, Cr, Cu) are inversely linked to glycemic control in type 2 diabetes individuals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">660</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Intanri Kurniati&lt;sup&gt;1&lt;/sup&gt;*, Agustyas Tjiptaningrum&lt;sup&gt;1&lt;/sup&gt;, Raja Iqbal Mulya Harahap&lt;sup&gt;2&lt;/sup&gt;, Bayu Putra Danan Jaya&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Lampung, Bandar Lampung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Padjajaran – Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Histology and Pathology Laboratory, Faculty of Medicine, Universitas Lampung, Bandar Lampung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Azizah</style></author><author><style face="normal" font="default" size="100%">Budi Santoso</style></author><author><style face="normal" font="default" size="100%">Abdurachman</style></author><author><style face="normal" font="default" size="100%">Hanik Badriyah Hidayati</style></author><author><style face="normal" font="default" size="100%">Ario Imandiri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Study is Examining How Postpartum Pain after Cesarean Section (SC) Can be Reduced by Boosting Levels of β-endorphin Through Electroacupuncture Stimulation at The Specified Points LI4 and SP6</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cesarean section</style></keyword><keyword><style  face="normal" font="default" size="100%">Electroacupuncture</style></keyword><keyword><style  face="normal" font="default" size="100%">LI4</style></keyword><keyword><style  face="normal" font="default" size="100%">Postpartum</style></keyword><keyword><style  face="normal" font="default" size="100%">SP6</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">670-676</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The physical healing process following a cesarean section surgery can induce anxiety and physiological stress due to wound pain, potentially impairing patient mobility and necessitating the administration of analgesic therapy. Pharmacological treatment sometimes proves insufficient or contraindicated for postpartum cesarean section patients, highlighting the need for non-pharmacological alternative therapies. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to investigate the impact of electroacupuncture (EA) stimulation at specific points SP6 and LI4 using frequencies of 30, 50, and 100 Hz on reducing pain intensity and increasing levels of the hormone β-endorphin in postpartum cesarean section patients. &lt;strong&gt;Method:&lt;/strong&gt; In this research, 144 postpartum cesarean section participants meeting inclusion criteria are divided into 8 groups, comprising intervention and control groups, utilizing a randomized control trial (RCT) technique. Pain intensity is measured using the pain numeric rating scale (PNRS), while levels of β-endorphin are analyzed through blood samples using the enzyme-linked immunosorbent assay (ELISA) method to compare outcomes before and after intervention. &lt;strong&gt;Result: &lt;/strong&gt;The analysis of the intervention group receiving electroacupuncture at specific points LI4 and SP6 has demonstrated effectiveness in reducing pain by increasing levels of the hormone β-endorphin, in comparison to the control group, with significant findings. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings of this study show that electroacupuncture intervention in postpartum cesarean section patients can stimulate an increase in β-endorphin hormone levels and effectively reduce postpartum cesarean section pain intensity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">670</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nurul Azizah&lt;sup&gt;1&lt;/sup&gt;, Budi Santoso2*, Abdurachman&lt;sup&gt;2&lt;/sup&gt;, Hanik Badriyah Hidayati&lt;sup&gt;2&lt;/sup&gt;, Ario Imandiri&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia, and Health Science Faculty Universitas Muhammadiyah Sidoarjo, Sidoarjo, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program of Medical Science Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Henniyati Harahap</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Anto J. Hadi</style></author><author><style face="normal" font="default" size="100%">Haslinah Ahmad</style></author><author><style face="normal" font="default" size="100%">Hapiz Arlanda Sani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Stunting and Family Socio-Cultural Determinant Factors: A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Family Behavior</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Education</style></keyword><keyword><style  face="normal" font="default" size="100%">Social Culture</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">268-275</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Stunting is a major public health problem in many developing countries including Indonesia and several ethnic groups have a very high prevalence of stunting which is caused by socio-cultural factors in the family. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to review family social and cultural factors in relation to stunting.&lt;strong&gt; Method: &lt;/strong&gt;This research uses a systematic review using the PRISMA method. There are 5 steps in this method namely determining the literature topic, searching for sources, selecting relevant sources, grouping and analyzing, and summarizing published research articles on family social culture on stunting published between 2018-2022 in the online article databases PubMed, Proquest, Scopus, Google Scholar and Sciencedirect. Data collection techniques by entering keywords in the database, keywords used: family social culture, intervention AND family environment risk of stunting*social demographics OR health education OR family empowerment OR maternal nutritional behavior OR family empowerment AND stunting. Screening consists of title, abstract, year of research, and methods used. Next, sorting the articles according to the predetermined inclusion criteria. The inclusion criteria in this study are: (1) Quantitative type of research with primary data; (2) Contains research results on socio-cultural factors that influence stunting in children; (3) the year the research was published in the last five years (2018-2022), (4) the sample used was families (children), (5) the text of the article was in English. A total of 18 of 1,544 articles met the inclusion criteria for this review material. &lt;strong&gt;Results:&lt;/strong&gt; This study shows that from the 18 selected articles it was found that stunting is caused by socio-cultural and family demographics, family nutritional behavior, and the family environment at risk of stunting. In addition, a model of health education and family empowerment based on family socio-culture was obtained. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study found that family social culture is a significant determinant of stunting.Therefore, further research needs to be carried out to complete our understanding of the complexity of the stunting problem.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">268</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Henniyati Harahap&lt;sup&gt;1,5&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;2&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;3&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;4&lt;/sup&gt;, Anto J. Hadi&lt;sup&gt;5&lt;/sup&gt;, Haslinah Ahmad&lt;sup&gt;5&lt;/sup&gt;, Hapiz Arlanda Sani&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;6,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program Student, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health Policy and Administration, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Health Promotion and Behavioral Sciences, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Public Health, Faculty of Health, Aufa Royhan University, Padangsidimpuan, North Sumatera, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cory Linda Futri Harahap</style></author><author><style face="normal" font="default" size="100%">Hakim Soleh Harahap</style></author><author><style face="normal" font="default" size="100%">Susi Yanti</style></author><author><style face="normal" font="default" size="100%">Elmi Sariani</style></author><author><style face="normal" font="default" size="100%">Anto J. Hadi</style></author><author><style face="normal" font="default" size="100%">Nefonavratilova Ritonga</style></author><author><style face="normal" font="default" size="100%">Haslinah Ahmad</style></author><author><style face="normal" font="default" size="100%">Hapiz Arlanda Sani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Testing the Effectiveness of Anti-Aging Cream Preparations with Snakefish Extract (Channa Striata)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-Aging Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Formula</style></keyword><keyword><style  face="normal" font="default" size="100%">Snakehead Fish Extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1164-1169</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Skin aging is caused by dry, rough, scaly, less elastic skin with wrinkles and fold lines. Snakehead fish extract has high antioxidant activity so it can be used as an active ingredient in &lt;em&gt;antiaging cosmetics&lt;/em&gt;.&lt;strong&gt; Objective: &lt;/strong&gt;The aim of this research was to see the effectiveness of snakehead fish extract cream as an &lt;em&gt;anti-aging agent&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;This research method includes formulating snakehead fish extract cream preparations with various concentrations including: 2.5% (F1), 5% (F2), 7.5% (F3), 10% (F4), evaluating the physical preparations in the form of: organoleptic test, homogeneity test, pH test, stability test, irritation test on volunteer skin, and&lt;em&gt; anti-aging effectiveness test&lt;/em&gt; on volunteer skin for 4 weeks with 3 parameter tests, namely water content, pores and wrinkles.&lt;strong&gt; Results:&lt;/strong&gt; The results of the study showed that there were changes that occurred in the volunteers as seen in the measurements of water content, pores and wrinkles on the volunteers' faces. A good increase in changes was found in the F4 formula (10%) in the wrinkle parameter test, namely 26.80%. The number of wrinkles in volunteers from some wrinkles to few wrinkles. The conclusion of this research shows that snakehead fish extract ( &lt;em&gt;Channa striata&lt;/em&gt; ) can be formulated in the form of a homogeneous cream dosage with a pH of 5.8 – 6.7, and is stable when stored for 12 weeks at room temperature and does not cause skin irritation. &lt;strong&gt;Conclusions: &lt;/strong&gt;There are differences in the results of each concentration of snakehead fish extract cream in influencing &lt;em&gt;anti-aging effectiveness&lt;/em&gt;. The best concentration of 10% snakehead fish extract showed better results compared to other creams in reducing the number of wrinkles on volunteers' facial skin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1164</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Cory Linda Futri Harahap&lt;sup&gt;1*&lt;/sup&gt;, Hakim Soleh Harahap&lt;sup&gt;1&lt;/sup&gt;, Susi Yanti&lt;sup&gt;1&lt;/sup&gt;, Elmi Sariani&lt;sup&gt;1&lt;/sup&gt;, Anto J. Hadi&lt;sup&gt;2&lt;/sup&gt;, Nefonavratilova Ritonga&lt;sup&gt;2&lt;/sup&gt;, Haslinah Ahmad&lt;sup&gt;2&lt;/sup&gt;, Hapiz Arlanda Sani&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Health, Aufa Royhan University, Padangsidimpuan, North Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Health, Aufa Royhan University, Padangsidimpuan, North Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alamsyah</style></author><author><style face="normal" font="default" size="100%">Lalu Muhammad Saleh</style></author><author><style face="normal" font="default" size="100%">Syamsiar S. Russeng</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Muh. Tahir Abdullah</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Tut Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Training Methods of Basic Life Support in Laypeople to Prevent Death Due to Cardiac Arrest: Scoping Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Basic Life Support</style></keyword><keyword><style  face="normal" font="default" size="100%">Laypeople.</style></keyword><keyword><style  face="normal" font="default" size="100%">Training</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">953-959</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Most major deaths worldwide are caused by cardiac arrest outside the home. Cardiac arrest is a fatal event and is still a major topic of public health. One effort that can be made to increase community knowledge and skills is to provide Basic Life Support (BLS) training using interesting methods. The purpose of this scoping review is to identify methods of BLS training in laypeople to prevent death from heart attacks. &lt;strong&gt;Methods:&lt;/strong&gt; We conducted a Scoping Review to identify BLS training methods in the community with a search process using appropriate populations, concepts, and contexts. The databases used for article searches are Science Direct, SAGE, PlosOne, Pubmed, NCBI, and Google Scholar. The selection process was carried out using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method and conducting a Critical Appraisal using The Joanna Briggs Institute checklist.&lt;strong&gt; Results&lt;/strong&gt;: From 2,996, 11 articles were selected in this review. Some of the training methods that can be carried out are in-person training, using mobile applications, CPR videos, and Virtual reality compression.&lt;strong&gt; Conclusion:&lt;/strong&gt; The BLS training methods can be used to increase the knowledge and skills of ordinary people.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">953</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Alamsyah&lt;sup&gt;1,2*&lt;/sup&gt;, Lalu Muhammad Saleh&lt;sup&gt;2&lt;/sup&gt;, Syamsiar S. Russeng&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;2&lt;/sup&gt;, Muh. Tahir Abdullah&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;, Tut Handayani&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Nursing Diploma III Study Program, Institute of Health Sciences&amp;nbsp;Pelamonia Kesdam XIV, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health,&amp;nbsp;Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Yanuar Safri</style></author><author><style face="normal" font="default" size="100%">Salim Harris</style></author><author><style face="normal" font="default" size="100%">Putera Dewa Haryono</style></author><author><style face="normal" font="default" size="100%">Ariane Benina Budiwan</style></author><author><style face="normal" font="default" size="100%">Eugenia Isadora</style></author><author><style face="normal" font="default" size="100%">Aisyah Fitriannisa Prawiningrum</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Unveiling Potential Therapies: Molecular Docking Analysis of CAMKK2 and Its Mutant Variants with CAMKK2 Inhibitors in Indonesian Patients with HIV-Sensory Neuropathy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CAMKK2 inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-SN</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">SNP</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">46-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;HIV sensory neuropathy (HIV-SN) is one among many complications that impair patients’ quality of life. Studies in Asian and African populations found that single nucleotide polymorphisms (SNPs) of calcium/ calmodulin-dependent protein kinase 2 (CAMKK2) influence the risk of HIV-SN. This study attempts to explain the influence of CAMKK2 mutations on HIV SN by studying bioinformatics interactions between CAMKK2, its mutants, and their inhibitors by molecular docking with AutoDock in order to observe their interactions with CAMKK2 inhibitors. Results showed that CAMKK2’s binding energy with its native ligand (ATP) is stronger than the mutant variant of CAMKK2MT85 and CAMKK2MT363. Conversely, interaction between CAMKK2 and its inhibitors (KN-93, STO-609, and trifluoperazine) have the lowest mean binding energy compared to CAMKK2MT85 and CAMKK2MT363. This indicates that the mutant variants have weaker interactions with the native ligand and the inhibitors, therefore disrupting the normal function of CAMKK2, its interactions with the inhibitors, while increasing the likelihood of HIV-SN.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">46</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ahmad Yanuar Safri&lt;sup&gt;1,2,3,&lt;/sup&gt;*, Salim Harris&lt;sup&gt;2,3&lt;/sup&gt;, Putera Dewa Haryono&lt;sup&gt;2,3&lt;/sup&gt;, Ariane Benina Budiwan&lt;sup&gt;2,3&lt;/sup&gt;, Eugenia Isadora&lt;sup&gt;2,3&lt;/sup&gt;, Aisyah Fitriannisa Prawiningrum&lt;sup&gt;4&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Bioinformatics Core Facilities IMERI, Medical Chemistry Department, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bambang Dwicahya</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Hasanuddin Ishak</style></author><author><style face="normal" font="default" size="100%">Firdaus Hamid</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aedes Sp. Mosquito Resistance and the Effectiveness of Biolarvicides on Dengue Vector Mortality</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aedes sp mosquito</style></keyword><keyword><style  face="normal" font="default" size="100%">Biolarvicides.</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue fever</style></keyword><keyword><style  face="normal" font="default" size="100%">Insecticide resistance</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">541-546</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Until now, dengue fever is still a public health problem in Indonesia. To control mosquito vectors, various strategic approaches have been promoted such as chemical control, biological control, resource reduction and public education. The four main classes that are widely used for mosquito control are organochlorines, organophosphates, pyrethroids and carbamates. A literature study was conducted to determine the extent of&lt;em&gt; Aedes aegypti&lt;/em&gt; resistance to several insecticides in several countries including Indonesia. This study also reviewed the effectiveness of biolarvicides on the mortality of &lt;em&gt;Aedes &lt;/em&gt;sp. All research that has been done in the last 10 years is included in this topic. In Brazil, Sri Lanka, China and Peru, there have been reports of resistance to &lt;em&gt;Aedes &lt;/em&gt;sp. against delthamethrin, pyrethroid and temephos insecticides. Meanwhile in Indonesia (Semarang, Surabaya, Banten, DKI Jakarta, North Sumatra, Jambi, Bandung, Bogor, Makassar and Palu),&lt;em&gt; Aedes &lt;/em&gt;sp. resistance occurs to insecticides of the pyrethroid, temephos, malathion, cypermethrin, and permethrin groups. Continuous monitoring of mosquito vector resistance status is very important in the effectiveness of dengue fever control. In addition, research on plants that can be used as biolarvicides is very useful for alternative control and improving public health. This review also provides better insight into the effectiveness of laboratory-tested plants as larvicides and plans for further research to be applicable to the community.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">541</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bambang Dwicahya&lt;sup&gt;1,*&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;2&lt;/sup&gt;, Hasanuddin Ishak&lt;sup&gt;2&lt;/sup&gt;, Firdaus Hamid&lt;sup&gt;3&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1,2&lt;/sup&gt;Faculty of public health, University of Tompotika, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of public health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Josina Hattu</style></author><author><style face="normal" font="default" size="100%">Darmawansyah</style></author><author><style face="normal" font="default" size="100%">Amran Razak</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Syamsiar S Russeng</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Determinants of Midwife Performance in Antenatal Care Services in Allang Care Health Centers Central Maluku District</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antenatal Care</style></keyword><keyword><style  face="normal" font="default" size="100%">Child health.</style></keyword><keyword><style  face="normal" font="default" size="100%">Health Center</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">547-552</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Antenatal care (ANC) is an important part of health care for pregnant women. Several studies conducted in high-income countries have shown that antenatal care can improve the care experience and health outcomes for pregnant women and newborns. This study aims to analyze the performance determinants of midwives in antenatal care services at the Allang Nursing Health Center, Central Maluku Regency. This type of research is a quantitative study with a cross sectional study approach. Respondents in this study were obtained by taking the entire population of 23 people using a questionnaire. Data processing was carried out using SPSS and for data analysis using statistical tests using univariate analysis tests, bivariate analysis tests and multivariate analysis tests. The results of this study indicate that there is a relationship between age, employee status and years of service to the performance of midwives in ANC services at the Allang Health Center, Central Maluku Regency and there is no relationship between knowledge and attitudes towards the performance of midwives in ANC services at Allang Health Center, Central Maluku Regency. Suggestions from this study are for the Office of Health and Midwives in Central Maluku District Provide policies in managing human resources for midwives with non-permanent employee status, with incentive arrangements that can improve performance in ANC services and carry out Antenatal care services with full sense of responsibility and seriously bearing in mind that the services provided are related to the scope of the Maternal and Child Health program to be achieved.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">547</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Josina Hattu&lt;sup&gt;1,*&lt;/sup&gt;, Darmawansyah&lt;sup&gt;2,*&lt;/sup&gt;, Amran Razak&lt;sup&gt;2&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;3&lt;/sup&gt;, Syamsiar S Russeng&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate program of of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, Makassar Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hasriani</style></author><author><style face="normal" font="default" size="100%">Andi Ummu Salmah</style></author><author><style face="normal" font="default" size="100%">Masni</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Knowledge and Skills of Cadres in Early Detection of Stunting Toddler Development in Soppeng Regency, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cadre</style></keyword><keyword><style  face="normal" font="default" size="100%">Development Disorders</style></keyword><keyword><style  face="normal" font="default" size="100%">Questionnaire.</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword><keyword><style  face="normal" font="default" size="100%">Survey</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">833-838</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; About 16% of Indonesian toddlers experience neuro developmental and brain disorders ranging from mild to severe, every two days 1,000 babies experience motor development disorders. The prevalence of stunting in South Sulawesi is in the 20th lowest ranking, namely 27.4% based on the provincial level in 2021. &lt;strong&gt;Objective:&lt;/strong&gt; Recognizing the increased knowledge and skill of cadre and mothers and toddlers in early development detection of stunted infants using a Developmental Pre-Screening Questionnaire (DPQ) in the working area of the Panincong Health Center, Soppeng Regency. &lt;strong&gt;Method:&lt;/strong&gt; This study used a quasi-experimental design with a pretest-posttest control group involving 30 cadres and 30 mothers with 15 children in each group selected by systematic random sampling. Data were analyzed using paired t-tests and Independent t-tests. &lt;strong&gt;Results&lt;/strong&gt;: The results showed that there were differences in knowledge (p=0.000) in the intervention group and differences in knowledge levels in the control group (p=0.044). The level of knowledge after treatment was greater in the intervention group (11.8%), while the knowledge after treatment in the control group was only (2.9%). There was a difference in the skills of the cadres (p=0.000) after being given the Android-based DPQ intervention. There was a difference in the knowledge (p=0.000) and skills of toddler mothers (p=0.000) after being given the Android-based DPQ intervention applied by the cadres. &lt;strong&gt;Conclusion: &lt;/strong&gt;Android-based DPQ is effective as an educational medium and as an alternative to cadres and parents in monitoring or early detection of child development using Android-based DPQ.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">833</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hasriani&lt;sup&gt;1&lt;/sup&gt;, Andi Ummu Salmah&lt;sup&gt;2,*&lt;/sup&gt;, Masni&lt;sup&gt;2&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;2&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;3&lt;/sup&gt;, Wahiduddin&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Student, Department of Reproduction Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Reproduction Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meidrin Joni</style></author><author><style face="normal" font="default" size="100%">Eryati Darwin</style></author><author><style face="normal" font="default" size="100%">Herlambang Herlambang</style></author><author><style face="normal" font="default" size="100%">Aisyah Elliyanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Analysis of Matrix Metalloproteinase-9 and Tissue Inhibitor Matrix Metalloproteinase-1 Levels in the Amniochorion Membrane Patients on Premature Rupture of Membranes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">MMP-9</style></keyword><keyword><style  face="normal" font="default" size="100%">Premature rupture of membranes.</style></keyword><keyword><style  face="normal" font="default" size="100%">TIMP-1</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">910-912</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; MMP-9 is essential for extracellular matrix remodeling, which affects the incidence of premature rupture of membranes. In addition, decreased and increased levels of TIMP-1, a preferential MMP-9 inhibitor, have been reported to be associated with premature rupture of membranes because it showed an imbalance in the MMP-9 or TIMP-1 levels. This study aims to analyze MMP-9 and TIMP-1 levels in amniochorion membrane patients on premature rupture of membranes. &lt;strong&gt;Methods:&lt;/strong&gt; An analytic observational study was conducted on 70 subjects. The MMP-9 and TIMP-1 levels in the amniochorion membrane were determined by ELISA. &lt;strong&gt;Results:&lt;/strong&gt; The results of this study indicate that the amniochorion membrane in the incidence of premature rupture of membranes is characterized by increased levels of MMP-9, while TIMP-1 levels do not differ between the incidence of premature rupture of membranes. &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on the research that has been done, it can be concluded that there are differences in protein levels of MMP-9 but there are no differences in protein levels of TIMP-1 in premature rupture of membranes&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">910</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Meidrin Joni&lt;sup&gt;1,*&lt;/sup&gt;, Eryati Darwin&lt;sup&gt;2&lt;/sup&gt;, Herlambang Herlambang&lt;sup&gt;3&lt;/sup&gt;, Aisyah Elliyanti&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Histology, Faculty of Medicine, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Sciences, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Radiology, Nuclear Medicine Division, Faculty of Medicine, Universitas Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herra Studiawan</style></author><author><style face="normal" font="default" size="100%">Sukardiman</style></author><author><style face="normal" font="default" size="100%">Indana Lazulfa</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Gastritis Activity of Cloves (Eugenia caryophyllata Thunberg) and Lime (Citrus aurantifolia) Leaf Extracts Combination in Absolute Alcohol Induced-Gastric Injury Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Citrus aurantifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Clove</style></keyword><keyword><style  face="normal" font="default" size="100%">Eugenia caryophyllata</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Lime</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">378-384</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Clove (&lt;em&gt;Eugenia caryophyllata &lt;/em&gt;Thunberg) and lime (&lt;em&gt;Citrus aurantifolia&lt;/em&gt;) are medicinal plants traditionally used to treat various diseases such as gastritis. Some studies reported that cloves leaf and lime leaf extract showed a gastroprotective effect by decreasing the gastric acid secretion and increasing the gastric mucus.&lt;strong&gt; Aim: &lt;/strong&gt;This study aims to investigate the anti-gastritis activity of the combination of ethanolic extract of cloves leaf and lime leaf extract in alcohol absolute-induced mice. &lt;strong&gt;Methods: &lt;/strong&gt;Mice were treated with the combination extract 0.7 g/kg BW, 1.4 g/kg BW, and 2.8 g/kg BW. Famotidine was used as a positive control, and Na CMC suspension was used as a negative control. After 45 minutes of oral administration, 0.14 ml/20g BW alcohol absolute was given to all mice. All groups were sacrificed one hour later. The evaluation showed that extract combination in all doses significantly decreased ulcer index (UI) compared to a negative control group (p&amp;lt;0.005) in macroscopic evaluation. &lt;strong&gt;Results: &lt;/strong&gt;In histopathologic evaluation, all doses significantly decreased mucosal edema and epithelial cell loss (p&amp;lt;0.005), but in gastric bleeding evaluation, only 0.7 and 1.4 g/kg BW doses showed a significant decrease. &lt;strong&gt;Conclusion&lt;/strong&gt;: This study showed that a combination of clove and lime leaf extracts has anti-gastritis activity and could be a possible therapeutic of anti-gastritis. The most effective dose is 1.4 g/kg BW in mice which showed the lowest ulcer index and gastric mucosal edema, bleeding and epithelial cells loss reduction on histopathological observation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herra Studiawan, Sukardiman*, Indana Lazulfa, Rosita Handayani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmaceutical Science Department, Faculty of Pharmacy, Airlangga University, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carlos Rodrigo Infante-Yupanqui</style></author><author><style face="normal" font="default" size="100%">Roberta García-de-la-Cruz</style></author><author><style face="normal" font="default" size="100%">Yanibel Hurtado-Vargas</style></author><author><style face="normal" font="default" size="100%">Rosa María Vega-Guevara</style></author><author><style face="normal" font="default" size="100%">Primy Agripina Alca-Chamba</style></author><author><style face="normal" font="default" size="100%">Rod Rosberg Bendezú-Perez</style></author><author><style face="normal" font="default" size="100%">Pavel Pool Puclla-Pareja</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comics in Health as Alternative Therapy: An Information and  Therapeutic Resource for Post-COVID-19 Patients in Ayacucho, Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1047-1051</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this research was to determine the utility of comics, as an informative and therapeutic resource, in post-COVID-19 patients, in the area of influence of the Camisea project, which is delimited to cities such as Huanta, Tambo, and Cangallo, located in Ayacucho, Peru. The methodology included an observational design, with in and out surveys being conducted during the study. The first survey sought to discover the level of approach of post-COVID-19 patients with the use of comics, while the second examined the effectiveness and usefulness after being exposed to a brochure of four comics (Figure 1) that combined humor and information related to the recovery procedures for COVID-19. The research showed that the usefulness of comics as an informative and therapeutic resource in post-COVID-19 patients in the city of Ayacucho is very significant. This was confirmed by 96% of those surveyed, since they pointed out that the comics contributed to virus infection recovery and prevention.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1047</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carlos Rodrigo Infante-Yupanqui*, Roberta García-de-la-Cruz, Yanibel Hurtado-Vargas, Rosa María Vega-Guevara, Primy Agripina Alca-Chamba, Rod Rosberg Bendezú-Perez, Pavel Pool Puclla-Pareja&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Social Sciences, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fares Khenniche</style></author><author><style face="normal" font="default" size="100%">Abderachid Slimani</style></author><author><style face="normal" font="default" size="100%">Chawki Bensouici</style></author><author><style face="normal" font="default" size="100%">Ibtissem Magboune</style></author><author><style face="normal" font="default" size="100%">Manel Srief</style></author><author><style face="normal" font="default" size="100%">Hamed Hakkom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative and Evaluative Study On Total Phenolic Content and Antioxidant Potential Within Hydromythanol Extracts and Their Fractions from All Parts of Drimia numidica (JORD. &amp; FOURR.) J.C. MANNING &amp; GOLDBLATT of Northeastern Algeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Drimia numidica</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydromythanol extracts and their fractions.</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">64-81</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Drimia numidica&lt;/em&gt; is a polyphenol-rich species that has antioxidant capacity, which makes it very important. Nevertheless, &lt;em&gt;D. numidica&lt;/em&gt; has not been studied in depth. Moreover, its capsules have not been studied so far. This detailed study compared the values of total phenolic content and antioxidant activity of all &lt;em&gt;D. numidica&lt;/em&gt; parts (scapes, flowers, bulbs, capsules, leaves, roots), from Edough Peninsula, Annaba, Algeria, using hydromethanol extracts and their fractions (cyclohexane, chloroform, ethyl acetate, and n-butanol). &lt;strong&gt;Methods&lt;/strong&gt;: The total phenolic content was determined by Folin Ciocalteo assay, and the antioxidant activity by the following methods: DPPH, Reducing Powder, Phenanthroline, Silver Nanoparticles, CUPRAC, and ABTS. Statistical analysis was done using the ANOVA test and a correlation test (between antioxidant activity and total phenolic content). &lt;strong&gt;Results: &lt;/strong&gt;The Ethyl acetate fraction was found the sample with the highest phenolic content. The same was true for the antioxidant activity in all tests except for the silver nanoparticles test in which cyclohexane extracts scored the best. Considering the methods used in general, there is a correlation between phenolic content and the highest antioxidant activity, but there are some methods that have not recorded any correlation. &lt;strong&gt;Conclusion: &lt;/strong&gt;Choosing the appropriate method or extract/fraction type is extremely important. In addition, extracts of &lt;em&gt;D. numidica &lt;/em&gt;parts could be an important natural alternative to antioxidants industrial.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">64</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fares Khenniche&lt;sup&gt;1,*&lt;/sup&gt;, Abderachid Slimani&lt;sup&gt;1&lt;/sup&gt;, Chawki Bensouici&lt;sup&gt;2&lt;/sup&gt;, Ibtissem Magboune&lt;sup&gt;2&lt;/sup&gt;, Manel Srief&lt;sup&gt;2,3&lt;/sup&gt;, Hamed Hakkom&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Plant Biology and Environnement «Médicinal Plants» Axis, Faculty of Sciences, University Badji Mokhtar- Annaba. BP 12, 23000 Annaba, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Biotechnology Research Center, Ali Mendjeli UV 3, PBOX 73, El Khroub, Constantine, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Biotechnology laboratory, National Higher School of Biotechnology, Constantine, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ali Abdallah Alqudah</style></author><author><style face="normal" font="default" size="100%">Bilal Al Hawamdeh</style></author><author><style face="normal" font="default" size="100%">Dahfer Ali</style></author><author><style face="normal" font="default" size="100%">Ibrahim Alfarrayeh</style></author><author><style face="normal" font="default" size="100%">Bilal Algataitat</style></author><author><style face="normal" font="default" size="100%">Omar Khaled Al-Mobideen</style></author><author><style face="normal" font="default" size="100%">Mohammad Alhawatema</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Antibacterial and Antioxidant Activities of Ethanolic Extracts of Four Plant Species Selected from South of Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Phenols</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">691-696</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the most ancient human medical techniques is the use of plants to treat, prevent, and cure diseases. These plants can manufacture a wide variety of natural chemicals. The present study aimed to evaluate the antibacterial activity and antioxidant capacity of ethanolic extract of four plant species (&lt;em&gt;Zizyphus lotus, Lavandula dentata, Ruta graveolens, and Dodonaea viscosa&lt;/em&gt;). Using disc diffusion and serial dilution procedures, the antibacterial abilities of these EtPEs were evaluated. The antioxidant properties were evaluated by the FRAP method and the Folin-Ciocalteu technique was used to measure the total phenolic content. Different plant extracts showed different inhibitory effects on the tested bacteria in a dose-dependent manner. Among the tested plant extracts, &lt;em&gt;D. viscose &lt;/em&gt;exhibited the highest antibacterial activity against&lt;em&gt; P. vulgaris &lt;/em&gt;and&lt;em&gt; S. aureus,&lt;/em&gt; with a minimum inhibitory concentration (MIC) value of 0.5 mg/ml. On the other hand, R. graveolens displayed the highest quantity of phenolic compounds and demonstrated the highest antioxidant activity. Notably, there was a positive correlation observed between the antioxidant activity of the plant extracts and their total phenolic content. In conclusion, the findings of this study suggest that the tested plant extracts hold potential as promising sources of natural antibacterial and antioxidant agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">691</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ali Abdallah Alqudah&lt;sup&gt;1,*&lt;/sup&gt;, Bilal Al Hawamdeh&lt;sup&gt;2&lt;/sup&gt;, Dahfer Ali&lt;sup&gt;3&lt;/sup&gt;, Ibrahim Alfarrayeh&lt;sup&gt;1&lt;/sup&gt;, Bilal Algataitat&lt;sup&gt;3&lt;/sup&gt;, Omar Khaled Al-Mobideen&lt;sup&gt;4&lt;/sup&gt;, Mohammad Alhawatema&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of applied Biology, Faculty of Science, Tafila Technical University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Emirates college for Advanced Education, Emirates, UAE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Science, Mu`tah University, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of paramedics, Prince Al-Hussein bin Abdullah II Academy of Civil Protection, AlBalqa' Applied University, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Niken Pratiwi</style></author><author><style face="normal" font="default" size="100%">Rutmauli Hutagaol</style></author><author><style face="normal" font="default" size="100%">Marwansyah</style></author><author><style face="normal" font="default" size="100%">Muhammad Pahruddin</style></author><author><style face="normal" font="default" size="100%">Erna Fauziah</style></author><author><style face="normal" font="default" size="100%">Parellangi</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Hb Levels Given Iron Supplements with and  Without Vitamin B12 to Anemia Female Industrial Workers in  Surakarta Residency Area</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron Deficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron Supplements</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin B12</style></keyword><keyword><style  face="normal" font="default" size="100%">Women Industrial Workers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1010-1015</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The research objective was to analyze the comparison of Hb levels given iron supplements with and without vitamin B12 in female industrial workers who experience anemia.&lt;strong&gt; Method: &lt;/strong&gt;The study used an experiment with a pretest-posttest control group design. The research respondents were female industrial workers who experienced anemia in the Surakarta Residency Area. The sampling method was carried out by purposive sampling. The number of samples was 33 respondents divided into a treatment group of 17 respondents and a treatment group of 16 respondents. &lt;strong&gt;Results:&lt;/strong&gt; There was no significant difference in hemoglobin levels in the control group and the treatment group as indicated by a p&amp;gt;0.05. The results of the paired t-test statistic showed that there was a significant change in hemoglobin levels in the treatment group (0,96 ± 0,40) p 0,000 (p&amp;lt;0,05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Giving iron supplementation to anemic women workers can increase hemoglobin levels. Handling of anemia in female workers can be done by making iron supplementation programs and policies in all companies that employ female workers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1010</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Niken Pratiwi&lt;sup&gt;1&lt;/sup&gt; , Rutmauli Hutagaol&lt;sup&gt;1,&lt;/sup&gt;*, Marwansyah1 , Muhammad Pahruddin&lt;sup&gt;1&lt;/sup&gt; , Erna Fauziah&lt;sup&gt;1&lt;/sup&gt; , Parellangi&lt;sup&gt;1&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;2 &lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Health Polytechnic Banjarmasin of Health Ministry, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Christina Noviasiata Djawa</style></author><author><style face="normal" font="default" size="100%">Sianny Herawati</style></author><author><style face="normal" font="default" size="100%">Ni Kadek Mulyantari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation Between Reticulocyte Hemoglobin Equivalent (RetHe) With Erythrocyte Indices in Predialytic Chronic Kidney Disease  Patients in Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Erythrocyte indices</style></keyword><keyword><style  face="normal" font="default" size="100%">Predialytic CKD</style></keyword><keyword><style  face="normal" font="default" size="100%">RET-He</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1064-1067</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Early detection and monitoring of anemia are important in CKD patients, which significantly increases the effectiveness of clinical treatment, reduce treatment cost and improve quality of life patients. Differential diagnosis of anemia based on conventional erythrocyte indices is limited, therefore it requires to be combined with other indices to determine iron deficiency. Reticulocyte hemoglobin equivalent (RET-He) is an alternative indicator of iron deficiency that is not affected by inflammation, and has been proposed as an additional marker for iron deficiency screening. &lt;strong&gt;Objective:&lt;/strong&gt; To determine the correlation between RET-He and erythrocyte indices (MCV, MCH, MCHC) in predialytic CKD patients.&lt;strong&gt; Method: &lt;/strong&gt;Cross-sectional retrospective study of predialytic CKD patient data in Prof. Ngoerah General Hospital, that were tested for RET-He and erythrocyte indices in January – March 2022. Data was collected from laboratory information system (LIS) and medical record. RET-He was measured with lightscatter flow cytometry method and erythrocyte indices was calculated.&lt;strong&gt; Result:&lt;/strong&gt; Sixty and three (63) study subjects were consisted of 37 men (58,7%) and 26 women (41,3%), with average of age was 60,68±10,52 years. The mean value of RET-He, MCV, MCH and MCHC was 30,55±2,86 pg, 89,08±7,78 fL, 28,76±2,72 pg, and 30,55±2,86 g/dL. Result of data analysis showed positive correlation between RET-He and MCV (r = 0,659), MCH (r = 0,734), and also between RET-He and MCHC (r = 0,383), with p &amp;lt; 0,05. &lt;strong&gt;Conclusion:&lt;/strong&gt; There was a significant positive correlation between RET-He with erythrocyte indices in predialytic CKD patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Christina Noviasiata Djawa&lt;/strong&gt;&lt;sup&gt;1,&lt;/sup&gt;&lt;strong&gt;*, Sianny Herawati&lt;sup&gt;2 &lt;/sup&gt;, Ni Kadek Mulyantari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Clinical Pathology Residency Education Program, Faculty of Medicine Udayana University, Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Udayana University/ Prof. Dr. I.G.N.G. Ngoerah General Hospital Denpasar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tarkeshwar Dubey</style></author><author><style face="normal" font="default" size="100%">Kancharla Bhanukiran</style></author><author><style face="normal" font="default" size="100%">Kuna Das</style></author><author><style face="normal" font="default" size="100%">Siva Hemalatha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development and Evaluation of Bio fabricated Silver Nanoparticles from Blumea lacera for In-vitro Antibacterial, Antioxidant and Anti-inflammatory Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC.</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Kukrounda</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytopharmaceuticals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">266-278</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Increasing prevalence of microbial resistance and side effects of currently available drugs compels the researchers to look for alternate therapies and formulations to overcome this problem. Plant based formulations have been proved to be most reliable agents in recent times. &lt;strong&gt;Objective: &lt;/strong&gt;In the current study, bio fabricated herbal silver nanoparticles (HSNPs) were prepared by reducing silver nitrate (AgNO&lt;sub&gt;3&lt;/sub&gt;) solution with ethyl acetate fractions (EAF) of &lt;em&gt;Blumea lacera &lt;/em&gt;extracts. These bios conjugated HSNPs were then assessed for potential anti-inflammatory and antibacterial activities along with&lt;em&gt; in vitro&lt;/em&gt; antioxidant effect. &lt;strong&gt;Methods and Results: &lt;/strong&gt;The synthesis was confirmed by absorbance peak at 441 nm due to surface plasmon resonance in UV-visible spectrophotometer. FTIR spectra of HSNPs indicated the phytochemicals having C-O bond responsible for reducing of Ag&lt;sup&gt;+&lt;/sup&gt; to Ag&lt;sup&gt;o&lt;/sup&gt;. Average size of HSNPs was found to be 59.21 nm which was in good agreement with TEM and SEM results. EDS analysis showed the existence of Silver, Nitrogen and Carbon in HSNPs. The antibacterial activity of HSNPs in terms of zone of inhibition (ZOI) &lt;em&gt;via&lt;/em&gt; disc diffusion assay and against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Escherichia coli &lt;/em&gt;was found to be 25.0±1.19 mm and 18.3±2.08 mm, respectively. The minimum inhibitory concentration (MIC) of HSNPs was found to be 50 μg/ml and 60 μg/ml against S. aureus and E. coli, respectively. The antioxidant capacity of the HSNPs was insignificant as compared to EAF but the results of anti-inflammatory activity was significant (p&amp;lt;0.05).&lt;strong&gt; Conclusion:&lt;/strong&gt; The overall result demonstrated better &lt;em&gt;in-vitro&lt;/em&gt; pharmacological potential of HSNPs compared to neat extract/EAF. Key words: Green synthesis, Phytopharmaceuticals, Inflammation, Kukrounda, HPTLC.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">266</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tarkeshwar Dubey&lt;sup&gt;1&lt;/sup&gt;, Kancharla Bhanukiran&lt;sup&gt;1&lt;/sup&gt;, Kuna Das&lt;sup&gt;2&lt;/sup&gt;, Siva Hemalatha&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Engineering &amp;amp; Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha-769008, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdul Hapid</style></author><author><style face="normal" font="default" size="100%">Ariyanti Ariyanti</style></author><author><style face="normal" font="default" size="100%">Erniwati Erniwati</style></author><author><style face="normal" font="default" size="100%">Ni Made Dharma Shantini Suena</style></author><author><style face="normal" font="default" size="100%">Ketut Agus Adrianta</style></author><author><style face="normal" font="default" size="100%">Karnita Yuniarti</style></author><author><style face="normal" font="default" size="100%">Muthmainnah Muthmainnah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Diversity of Types of Medicinal Plants and Local Wisdom of the Kaili Tribe in Processing Medicinal Plants Around the Forest Areas of Central Sulawesi, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Kaili tribe</style></keyword><keyword><style  face="normal" font="default" size="100%">Local knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Species diversity.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">535-540</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The forest area in Sigi Regency, Central Sulawesi, is a habitat for various medicinal plant species. Forest areas must be managed appropriately for the local community and society's welfare and sustainable use. One of the local people living around the forest is the Kaili tribe. The local wisdom of the Kaili tribe, who inhabit forest areas in Central Sulawesi, in managing forests and forest products, especially using plants as medicine, must be documented in research. This study aimed to identify the species, habitat, habitus, and ways of using the plant as medicine by the Kaili people in the Sigi Regency. Prior to data collection, a literature study was conducted to obtain information regarding the condition of the research location around the forest area and the ethnic/ethnic groups who live permanently around and within the forest area. This stage was then followed by interviews and field surveys. The interviews were conducted by combining purposive sampling and snowball methods. The results showed the high potency of medicinal plants around forest areas used by the Kaili tribe, with the discovery of 113 species in 51 families. Herbs are the most common habitus of medicinal plants. The habitat of medicinal plants is mainly found in the yard. The most used plant part is the leaves, which can be boiled in water and drunk directly.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">535</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdul Hapid&lt;sup&gt;1,*&lt;/sup&gt;, Ariyanti Ariyanti&lt;sup&gt;1&lt;/sup&gt;, Erniwati Erniwati&lt;sup&gt;1&lt;/sup&gt;, Ni Made Dharma Shantini Suena&lt;sup&gt;2&lt;/sup&gt;, Ketut Agus Adrianta&lt;sup&gt;3&lt;/sup&gt;, Karnita Yuniarti&lt;sup&gt;4&lt;/sup&gt;, Muthmainnah Muthmainnah&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Forestry, Faculty of Forestry, Tadulako University, Palu, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutics, Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Research Center for Biomass and Bioproduct, National Research and Innovation Agency of Indonesia, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Septina Hestiningrum</style></author><author><style face="normal" font="default" size="100%">Nur Ismi Mustika Febriani</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Ratih Tri Kusuma Dewi</style></author><author><style face="normal" font="default" size="100%">Santy Ayu Puspita Perdhana</style></author><author><style face="normal" font="default" size="100%">Nurhasan Agung Prabowo</style></author><author><style face="normal" font="default" size="100%">Yeremia Suryo Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Channa striata Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease Patients: A Randomized Controlled Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Channa striata</style></keyword><keyword><style  face="normal" font="default" size="100%">End-stage renal disease</style></keyword><keyword><style  face="normal" font="default" size="100%">hs-CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Supplementation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Albumin is a marker of nutritioinal inflammation and mortality. Chronic inflammation, as indicated by the concentration of a proinflammatory cytokine, high sensitivity C-reactive protein (hs-CRP) was reported to be high in end-stage renal disease (ESRD) patients. &lt;em&gt;Channa striata&lt;/em&gt; (CS) contains high protein that can increase albumin levels and has anti-inflammatory effects. This study was conducted to determine the effect of CS extract on serum albumin and hs-CRP on ESRD patients. &lt;strong&gt;Methods: &lt;/strong&gt;This study is a randomized, double blind, placebo-controlled study in patients with ESRD on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Subjects were randomized to either a CS or a placebo group and were given a three times daily dosage of 500 mg of CS extract or 500 mg maltodextrin, respectively for 21 days. Serum albumin and hs-CRP were measured at the baseline, and at the end of the study. &lt;strong&gt;Result: &lt;/strong&gt;Forty subjects were randomized into the study with 20 in the &lt;em&gt;Channa striata &lt;/em&gt;group and 20 in the placebo group, with HD and CAPD patient evenly distributed among the group. Significant increase in serum albumin levels (p&amp;lt;0,001) and significant decrease of hs-CRP (p&amp;lt;0,001) were observed in the treatment group compared to control group at the end of the study. At the end of the study, there was no significant difference between serum albumin, hs-CRP, and their gradient between HD and CAPD patients in the intervention group. &lt;strong&gt;Conclusion: &lt;/strong&gt;CS extract results in higher serum albumin and lower hs-CRP levels compared to placebo in our population.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wachid Putranto&lt;sup&gt;1,2,*&lt;/sup&gt;, Septina Hestiningrum&lt;sup&gt;1,2&lt;/sup&gt;, Nur Ismi Mustika Febriani&lt;sup&gt;1,2&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;3&lt;/sup&gt;, Ratih Tri Kusuma Dewi&lt;sup&gt;1,2&lt;/sup&gt;, Santy Ayu Puspita Perdhana&lt;sup&gt;1,2&lt;/sup&gt;, Nurhasan Agung Prabowo&lt;sup&gt;2,4&lt;/sup&gt;, Yeremia Suryo Pratama&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Sebelas Maret University, Surakarta, Jl. Ir. Sutami 36, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Sebelas Maret University Hospital, Jl. A. Yani 200, Sukoharjo, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rasio Putra Hutama</style></author><author><style face="normal" font="default" size="100%">Alpha Fardah Athiyyah</style></author><author><style face="normal" font="default" size="100%">I.G.M. Reza Gunadi Ranuh</style></author><author><style face="normal" font="default" size="100%">Andy Darma</style></author><author><style face="normal" font="default" size="100%">Khadijah Rizky Sumitro</style></author><author><style face="normal" font="default" size="100%">Wibi Riawan</style></author><author><style face="normal" font="default" size="100%">Ingrid S. Surono</style></author><author><style face="normal" font="default" size="100%">Subijanto Marto Sudarmo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Lactobacillus Plantarum IS-10506 on Paneth Cell Regeneration in the Ileum of Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DEFA-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Escherichia coli O55:B5</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactobacillus plantarum IS-10506</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipopolysaccharide</style></keyword><keyword><style  face="normal" font="default" size="100%">MATH-1.</style></keyword><keyword><style  face="normal" font="default" size="100%">Paneth cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">928-932</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pathogenic &lt;em&gt;Escherichia coli &lt;/em&gt;(E. coli) is the most common infectious agent among children in developing countries. Indigenous probiotics are not widely used to treat diarrhea and intestinal infections. This study aims to investigate the cell regeneration process of paneth cells after administration of &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 due to damage caused by Lipopolysaccharide (LPS) &lt;em&gt;E. coli&lt;/em&gt; O55:B5, through the expression of MATH-1 and DEFA-6. &lt;strong&gt;Methods: &lt;/strong&gt;This study used 64 paraffin blocks from Rattus norvegicus strain Sprague-Dawley divided into four groups. There were three treatments, KN, KL, KP and KPR groups, The KN group represent the administration of placebo. The KL group received LPS &lt;em&gt;E. coli &lt;/em&gt;O55:B5 on day one. The KP group received LPS &lt;em&gt;E. coli&lt;/em&gt; O55:B5 on the first day and &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 on the second day until six-day. The KPR group were administered &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS- 10506 six days prior to receiving LPS &lt;em&gt;E. coli&lt;/em&gt; O55:B5, respectively. All groups, except KN, received LPS at a dose of 250 μg/kg body weight once, and Lactobacillus plantarum IS-10506 at a dose of 2.86x1010 CFU/ day. Evaluating paneth cell regeneration, DEFA-6, and MATH-1 expression immunohistochemistry was conducted on all tissues. &lt;strong&gt;Results:&lt;/strong&gt; The expression of DEFA-6 and MATH-1 in the KP and KPR groups on day three of observation was significantly higher from the KL group. Even though the KL group achieved significant growth, the results of this expansion were significantly smaller than KP and KPR groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; After mucosal injury caused by LPS &lt;em&gt;E. coli &lt;/em&gt;O55:B5, administration of probiotic &lt;em&gt;Lactobacillus plantarum&lt;/em&gt; IS-10506 may increase paneth cell regeneration through differentiation and cell number.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">928</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rasio Putra Hutama&lt;sup&gt;1&lt;/sup&gt;, Alpha Fardah Athiyyah&lt;sup&gt;1,*&lt;/sup&gt;, I.G.M. Reza Gunadi Ranuh&lt;sup&gt;1&lt;/sup&gt;, Andy Darma&lt;sup&gt;1&lt;/sup&gt;, Khadijah Rizky Sumitro&lt;sup&gt;1&lt;/sup&gt;, Wibi Riawan&lt;sup&gt;2&lt;/sup&gt;, Ingrid S. Surono&lt;sup&gt;3&lt;/sup&gt;, Subijanto Marto Sudarmo&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine Universitas Airlangga. Dr. Soetomo General Academic Teaching Hospital, Mayjend. Prof. Dr. Moestopo No. 6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry and Biomolecular Universitas Brawijaya, Veteran Street, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Food Technology Department, Faculty of Engineering, Bina Nusantara University, Jakarta 11480, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">A. Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Aminuddin Syam</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Abd. Farid Lewa</style></author><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Moringa Leaf Extract Intervention Since Preconception Period on the Prevention of Oxidative Stress in Pregnant Women and Adverse Pregnancy Outcomes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malondialdehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">310-314</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Oxidative stress occurs due to an imbalance of oxidants and anti-oxidants and is often associated with poor pregnancy outcomes. Therefore, additional supplementation is needed since the preconception period to prevent oxidative stress and poor pregnancy outcomes. This study aims to examine the effect of supplementing Moringa leaf extract on the prevention of oxidative stress in pregnant women and poor pregnancy outcomes. &lt;strong&gt;Methods: &lt;/strong&gt;This study is an observational study with a prospective cohort study design. The research subjects were third trimester pregnant women consisting of 2 groups, namely the control group who only received Iron-Folic Acid (IFA) supplements (n = 30) and the group that received moringa leaf extract and IFA supplements (n = 26). Then an examination of Malondialdehyde (MDA) levels as a biomarker of oxidative stress was carried out using the ELISA (enzyme-link immune sorbent) method, followed by pregnancy outcomes including birth weight and birth length. Data were analyzed by unpaired t test. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that there were no significant differences in the levels of MDA, birth weight and birth length in the two groups with a p value &amp;gt; 0.05. Nevertheless, MDA level in IFA group was 49.25 nmol/ml higher than Moringa + IFA group which was 47.58 nmol/ml. Likewise, the average of birth weight and birth length in Moringa group were 3042.3 grams and 48.62 cm higher than IFA group which were 2993.7 grams and 48.23 cm. Malondialdehyde levels were also higher in women who had babies with birth weight &amp;lt; 2500 grams was 49.48 nmol/ml and birth length &amp;lt; 48 cm was 49.13 nmol/l compared to birth weight ≥ 2500 grams was 48.50 nmol/ml and birth length ≥ 48 cm was 48.62 nmol/ml but there was no significant difference in the two groups (p&amp;gt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Oxidative stress in pregnant women tends to be associated with poor pregnancy outcomes. Moringa leaf extract supplementation since preconception can prevent increased oxidative stress and improve pregnancy outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">310</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahma&lt;sup&gt;1,*&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, A. Arsunan Arsin&lt;sup&gt;3&lt;/sup&gt;, Aminuddin Syam&lt;sup&gt;2&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;, Abd. Farid Lewa&lt;sup&gt;5&lt;/sup&gt;, Haerani Harun&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Enviromental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Nutrition health, Polytechnic of Palu, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gilmar Peña-Rojas</style></author><author><style face="normal" font="default" size="100%">Luz Quispe-Calle</style></author><author><style face="normal" font="default" size="100%">Vidalina Andía-Ayme</style></author><author><style face="normal" font="default" size="100%">Alex Pereda-Medina</style></author><author><style face="normal" font="default" size="100%">Rolando Estrada- Jimenez</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Naphthaleneacetic Acid (NAA) and 6-Benzylamino Purine (BAP) on In-Vitro Propagation of &quot;Mashua&quot; (Tropaeolum tuberosum Ruíz &amp; Pavón) Morphotypes from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BAP.</style></keyword><keyword><style  face="normal" font="default" size="100%">Mashua</style></keyword><keyword><style  face="normal" font="default" size="100%">Micropropagation</style></keyword><keyword><style  face="normal" font="default" size="100%">NAA</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropaeolum tuberosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">563-568</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruız &amp;amp; Pavón “mashua” is a native species of the central Andes and different propagation methods&lt;em&gt; in vitro &lt;/em&gt;have been evaluated. However, this research has studied the &lt;em&gt;in vitro &lt;/em&gt;propagation of 15 mashua (&lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón) morphotypes from the Ayacucho and Apurímac regions (Peru) &lt;strong&gt;Objective: &lt;/strong&gt;To evaluate the effect of the additives naphthaleneacetic acid (NAA) and 6-benzylamino purine (BAP) on the micro-propagation rate of &lt;em&gt;T. tuberosum&lt;/em&gt;. &lt;strong&gt;Material and Methods: &lt;/strong&gt;For &lt;em&gt;in vitro&lt;/em&gt; establishment, seedlings were used after disinfection with sodium hypochlorite, propagated in Murashige and Skoog (MS) medium. For the evaluation of the effect of NAA and BAP additives, nodes were isolated from &lt;em&gt;in vitro&lt;/em&gt; seedlings after 30 days of cultivation and transferred to MS medium supplemented with 3% sucrose, pH 5.6 and 7 g/L of agar according to T1 (MS + NAA 1ppm) and T2 (MS + BAP 1ppm) treatments. The samples were cultivated for 28 days at 19 °C ± 2 °C with photoperiods of 16 h/light and 8 h/darkness.&lt;strong&gt; Results: &lt;/strong&gt;After evaluating 20 repetitions for each of the three treatments, the addition of NAA or BAP does not improve the micropropagation rate of practically all the morphotypes studied. Furthermore, BAP behaved as an inhibitor of the development of mashua seedlings. &lt;strong&gt;Conclusion: &lt;/strong&gt;The best micropropagation medium of &lt;em&gt;Tropaeolum tuberosum&lt;/em&gt; Ruíz &amp;amp; Pavón (mashua) is the basic Murashige and Skoog (MS) medium without the NAA or BAP additives.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gilmar Peña-Rojas&lt;sup&gt;1,*&lt;/sup&gt;, Luz Quispe-Calle&lt;sup&gt;1&lt;/sup&gt;, Vidalina Andía-Ayme&lt;sup&gt;2&lt;/sup&gt;, Alex Pereda-Medina&lt;sup&gt;3&lt;/sup&gt;, Rolando Estrada- Jimenez&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;6&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Cellular and Molecular Biology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Food Microbiology, Biological Sciences Faculty, Universidad Nacional de San Cristóbal de Huamanga, Portal Independencia 57, Ayacucho 05003, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratorio de Teledetección y Física. Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05003 PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratorio de Recursos Genéticos y Biotecnología, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Pharmacy and Biochemistry Faculty, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Anwar Daud</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">M Sabir</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author><author><style face="normal" font="default" size="100%">Tamrin Talebe</style></author><author><style face="normal" font="default" size="100%">M. Faris</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Preconcenption Moringa Leaf Extract Supplementation on Cotinine Serum Levels in Pregnant Women Exposed to Tobacco Smoke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cotinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera.</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Tobacco smoke</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">290-293</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is known for its nutrition content, antioxidant and medical benefit. Tobacco smoke contains various toxic substance and can affect the pregnancy. To reduce the tobacco smoke effect on pregnancy outcome good nutrition is needed. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to assess the effect of Moringa leaf extract on serum cotinine levels in pregnant women exposed to second-hand tobacco smoke.&lt;strong&gt; Method:&lt;/strong&gt; This is an observational study with a prospective cohort study design the study population was pregnant women which were divided by 2 groups, first group received IFA supplements only (n = 30) and the second group receive IFA and Moringa leaf extract supplements (n = 26). The tobacco smoke exposure data collected with questionnaire, and cotinine serum by blood sample. The tobacco smoke exposure and cotinine serum levels were compered between the two groups.&lt;strong&gt; Results: &lt;/strong&gt;The tobacco smoke exposures at home were higher in MO+IFA group pregnant women then the IFA group pregnant women (p&amp;lt;0,05). The cotinine serum levels in both groups were found not significantly different (p=0,535). These results indicate that pregnant woman with high exposure of tobacco smoke who MO receive have similar cotinine serum levels with the pregnant woman with lower exposure of tobacco smoke. &lt;strong&gt;Conclusion:&lt;/strong&gt; Moringa leaf extract supplementation to pregnant women with high tobacco smoke exposure has serum cotinine levels similar to pregnant women with lower exposure to tobacco smoke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Haerani Harun&lt;sup&gt;1,*&lt;/sup&gt;, Anwar Daud&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, M Sabir&lt;sup&gt;4&lt;/sup&gt;, Veni Hadju&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;, Rahma&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;4&lt;/sup&gt;, Tamrin Talebe&lt;sup&gt;6&lt;/sup&gt;, M. Faris&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Enviromental Health, Public Health Faculty Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Microbiology,Medical faculty Tadulako University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Associate professor, Ushuluddin Faculty, Datokarama State Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irham Taufiqurrahman</style></author><author><style face="normal" font="default" size="100%">Siti Hajar Norma Gupita</style></author><author><style face="normal" font="default" size="100%">Beta Widya Oktiani</style></author><author><style face="normal" font="default" size="100%">Isyana Erlita</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Eko Suhartono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ramania Leaves Extract Gel (Bouea macrophylla  Griff) on the Number of Osteoblast (in vivo Study of Post  Extraction in Wistar Rats (Rattus norvegicus))</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bouea macrophylla Griff</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteoblast</style></keyword><keyword><style  face="normal" font="default" size="100%">Ramania leaf extract gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary  metabolite</style></keyword><keyword><style  face="normal" font="default" size="100%">Tooth extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1219-1223</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ramania leaves extract contains secondary metabolite compounds such as flavonoids, steroids, phenols and terpenoids which can be used as an alternative medicine for socket wound healing. Flavonoids have anti-inflammatory and antioxidant properties that can accelerate wound healing and can stimulate the formation of osteoblasts. Analyzing the differences in the number of osteoblasts in the negative control group, positive control given aloe vera gel 15% and ramania leaf extract gel 15% on day 5, 7 and 14. This study used true experimental design with posttest-only control design, using 27 rats divide into 3 groups. The experimental animals were sacrificed on days 5, 7 and 14 for histopathological observations. Two-Way ANOVA test results obtained p value = 0.013 &amp;lt;0.05, which indicates that there is a significant difference between the use of 15% ramania leaf extract gel 15% and the number of osteoblasts on days 5, 7 and 14. Bonferroni's Post Hoc test showed a difference. The number of osteoblasts was significant among the negative control group with ramania leaf extract gel 15%. Ramania leaf extract gel 15% was proven to be able to increase the number of osteoblasts and has the potential as an alternative medicine for socket healing after tooth extraction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1219</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irham Taufiqurrahman&lt;sup&gt;1,2,&lt;/sup&gt;*, Siti Hajar Norma Gupita&lt;sup&gt;3&lt;/sup&gt; , Beta Widya Oktiani&lt;sup&gt;4&lt;/sup&gt; , Isyana Erlita&lt;sup&gt;5&lt;/sup&gt; , Andi Zulkifli&lt;sup&gt;6&lt;/sup&gt; , Veni Hadju&lt;sup&gt;6&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;6&lt;/sup&gt; , Eko Suhartono&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Periodontist, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Departement of Conservative Dentistry, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar – INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Departement of Medical Chemistry/ Biochemistry, Faculty of Medicine, Lambung Mangkurat University, Banjarbaru, South Kalimantan – INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Saiful Ardhi</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Achmad Chusnu Romdhoni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Thiamine on Serum Glutamate in Ischemic Stroke Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">Glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Ischemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Stroke.</style></keyword><keyword><style  face="normal" font="default" size="100%">Thiamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">390-392</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Thiamin or vitamin b1 is a therapy that has been widely used in neurology cases such as alcohol-induced encephalopathy and neuropathy. Thiamin has the ability to penetrate the blood brain barrier so that it is expected to be used as an additional therapy in stroke cases. Stroke is currently an emergency neurology case that causes high mortality and disability. Among the causes is because damage to large areas of the brain will cause the release of neurotransmitters such as glutamate which has excitotoxicity effects to the brain when excessive. &lt;strong&gt;Method: &lt;/strong&gt;This study used animal models of carotid artery occlusion stroke. Divided into 4 groups: control, thiamin dose of 100mg/kg, Thiamin 200mg/kg, and 400mg/kg. Serum glutamate was collected on day 7 post-action. Then evaluated by ELISA method. &lt;strong&gt;Results:&lt;/strong&gt; There was a significant difference in the form of a decrease in the average serum glutamate level between the control and the sample that received a dose of thiamine 200mg/kg and 400mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;High-dose thiamine may be considered as an additional therapy in cases of carotid artery occlusion model stroke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">390</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mohammad Saiful Ardhi&lt;sup&gt;1,2&lt;/sup&gt;, Muhammad Hamdan&lt;sup&gt;2,*&lt;/sup&gt;, Achmad Chusnu Romdhoni&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya 60132, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, 60132, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, 60132, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">Rini Apriliawati</style></author><author><style face="normal" font="default" size="100%">Sunaryo Hadi Warsito</style></author><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Widya Paramita Lokapirnasari</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Mohammad Anam Al-Arif</style></author><author><style face="normal" font="default" size="100%">Mirni Lamid</style></author><author><style face="normal" font="default" size="100%">Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Sarasati Windria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Supplementation of Microbiota Inoculant in the Early Laying Hens Feed on High Density Lipoprotein (HDL) and Low- Density Lipoprotein (LDL) in Egg Yolk</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">High Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Laying hens</style></keyword><keyword><style  face="normal" font="default" size="100%">Low Density Lipoprotein</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">270-273</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Laying hens (&lt;em&gt;Gallus gallus&lt;/em&gt;) are one of the poultries kept for their eggs. Eggs produced by chickens are used as a source of human food that contains a lot of nutrition and is affordable. Eggs also contain high levels of cholesterol in the yolk, so if consumed in large quantities, they will pose a risk of disease. This study aims to determine the effect of giving probiotics in the early layer laying hen feed on the levels of high-density lipoprotein and low-density lipoprotein in egg yolks. This study has four treatments, namely P1 = control, P2 = feed + AGP, and P3 and P4 = feed + probiotics. The probiotic used is a combination of three bacteria, namely Lactobacillus plantarum, Lactobacillus acidophilus, and Bifidobacterium sp. The sample used in this study was egg yolk, which was collected in the last week of the study. Testing for HDL and LDL levels in egg yolks was carried out using the Quantitative Colorimetric/Fluorometric Determination of HDL and LDL/VLDL method. Testing HDL and LDL levels in this study showed that the administration of probiotics had an effect in the form of increasing HDL levels but did not have an effect in the form of a significant decrease in egg yolk LDL levels during the four-week treatment period in laying hens in the early layer phase, aged 18–22 weeks. The best probiotic dose used among the three probiotic doses is 3 ml/kg of feed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">270</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bodhi Agustono&lt;sup&gt;1*&lt;/sup&gt;, Rini Apriliawati&lt;sup&gt;1&lt;/sup&gt;, Sunaryo Hadi Warsito&lt;sup&gt;6&lt;/sup&gt;, Maya Nurwartanti Yunita&lt;sup&gt;2&lt;/sup&gt;, Widya Paramita Lokapirnasari&lt;sup&gt;6&lt;/sup&gt;, Sri Hidanah&lt;sup&gt;6&lt;/sup&gt;, Emy Koestanti Sabdoningrum&lt;sup&gt;6&lt;/sup&gt;, Mohammad Anam Al-Arif&lt;sup&gt;6&lt;/sup&gt;, Mirni Lamid&lt;sup&gt;6&lt;/sup&gt;, Gandul Atik Yuliani&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Sarasati Windria&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Animal Husbandry, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Pathology Veteriner, School of Health and Life Sciences (SIKIA), Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Basic Veterinary, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biomedical Science, Faculty of Medicine, Universitas Padjajaran, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Division of Animal Husbandry, Department of Veterinary Science, Faculty of Veterinary Medicine Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sulistiawati</style></author><author><style face="normal" font="default" size="100%">Miranda Jemyma Mas’ulun</style></author><author><style face="normal" font="default" size="100%">Anggita Kanza Ramadhany</style></author><author><style face="normal" font="default" size="100%">Afiel Nadhifa Hanafie</style></author><author><style face="normal" font="default" size="100%">Rani Fitri Alfiani</style></author><author><style face="normal" font="default" size="100%">Sarah Evita Husnah</style></author><author><style face="normal" font="default" size="100%">Agnes Ilene Suprapto Puteri</style></author><author><style face="normal" font="default" size="100%">Anisa Novia Mahestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of the Aedes aegypti Mosquito Vector Control Program in Southeast Asia – A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aedes aegypti</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue Control Program</style></keyword><keyword><style  face="normal" font="default" size="100%">human and health</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Tropical Disease.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">969-975</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dengue is still a major vector-borne disease problem in the world. It is caused by infection with the Dengue virus, which can be spread through a vector in the form of the Aedes aegypti mosquito. One of the ways to reduce the incidence of dengue infection is by controlling vectors. &lt;strong&gt;Aim: &lt;/strong&gt;This study aims to analyze the effectiveness of vector control of the Aedes aegypti mosquito on the dengue incidence in Southeast Asia. Methods and findings: This study was a systematic review that examines articles with experimental research designs and cluster randomized controlled trials. The scope of this research area is limited to Southeast Asian countries during 2012-2021. There are 333 articles obtained from two sources: PubMed and ScienceDirect, by using certain keywords. Furthermore, articles were selected based on inclusion and exclusion criteria, so that 31 articles were obtained. A total of 6 articles that met the inclusion criteria were then selected for further analysis. Three journals that discussed the output in the form of the Larva Density Index (LDI) showed a decrease with significant results. Two journals that discussed biological control (Bacillus thuringiensis israelensis) got significant results in decreasing Pupal Density (PD). The two journals on chemical control (permethrin) that discussed the outcome of the presence or absence of IgG seroconversion show insignificant results.&lt;strong&gt; Conclusion&lt;/strong&gt;: All control methods are considered effective. However, among the three vector control methods studied, the control with Bacillus thuringiensis israelensis is the most effective method.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">969</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sulistiawati&lt;sup&gt;1,*&lt;/sup&gt;, Miranda Jemyma Mas’ulun&lt;sup&gt;2&lt;/sup&gt;, Anggita Kanza Ramadhany&lt;sup&gt;2&lt;/sup&gt;, Afiel Nadhifa Hanafie&lt;sup&gt;2&lt;/sup&gt;, Rani Fitri Alfiani&lt;sup&gt;2&lt;/sup&gt;, Sarah Evita Husnah&lt;sup&gt;2&lt;/sup&gt;, Agnes Ilene Suprapto Puteri&lt;sup&gt;2&lt;/sup&gt;, Anisa Novia Mahestari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Undergraduated student, Faculty of Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Komal KP</style></author><author><style face="normal" font="default" size="100%">Guruvayoorappan C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Emilia Sonchifolia-A Critical and Comprehensive Review of its  Diverse Medicinal Potential and Future as Therapeutic</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Emilia sonchifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1143-1149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Emilia sonchifolia&lt;/em&gt; (L.) DC, it belongs to the family Asteraceae or Compositae, is conventionally used in ethnomedicine, and acquires various medicinal properties. This plant has been regarded as one of the widespread traditional vegetable salads in Malaysia, Bangladesh, and India. In addendum to its avail as a vegetable, the plant has been documented with several medicinal benefits in the extravagance of night blindness, epilepsy, malaria, asthma, burns, breast abscesses, and inflammatory diseases. On scrutinization of their pharmacological properties, it has been revealed that they possess numerous notable biological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, hepatoprotective, antianxiety, and anticataract, as well as anticonvulsant activities. Concrete evidence suggests the presence of potential phytochemicals in this plant with a wide range of unknown applications. In this current review, we discuss the phytochemicals present in the plant &lt;em&gt;Emilia sonchifolia &lt;/em&gt;and emphasize the therapeutic and pharmacological activities reported so far concerning this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sardar Hussain&lt;sup&gt;1&lt;/sup&gt; , Komal KP&lt;sup&gt;2&lt;/sup&gt; , Guruvayoorappan C&lt;sup&gt;3&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Scholar, R&amp;amp;D Centre, Bharathiar University, Coimbatore 641 046, Tamil Nādu; Assistant Professor, Department of Biotechnology, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Associate Professor, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 011, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Mally Ghinan Sholih</style></author><author><style face="normal" font="default" size="100%">Nitya Nurul Fadilah</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Surya Amal</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Lina Aliyani Mardiana</style></author><author><style face="normal" font="default" size="100%">Diany Astuti</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antidiarrheal, Antispasmodic, and Antisecretory Activities of Extract and Fractions of Castanopsis costata Leaves in Animal Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal models</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">31-37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The use of traditional medicinal plants &lt;em&gt;Castanopsis costata &lt;/em&gt;in the management of diarrhea is an ancient practice in North Sumatra, Indonesia, but its safety and efficacy have not been examined scientifically in animal models. Therefore, this study aims to determine the antidiarrheal effect of &lt;em&gt;C. costata&lt;/em&gt; leaf extract and fractions&lt;em&gt; in vivo&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;The antidiarrheal activity was evaluated against animal models of diarrhea induced by castor oil, charcoal meal, and entero-pooling test. The extract group received doses of 25, 50, 100, and 200 mg/kg, while the fraction groups was treated with WFCC, EAFCC, and nHFCC, in doses of 50 and 100 mg/kg, respectively. The negative control received 10 mL/kg of the dissolving vehicle, while the positive was treated with loperamide 3 mg/kg.&lt;strong&gt; Results&lt;/strong&gt;: The results showed that EECC doses of 200 mg/kg, WFCC, and EAFCC at 50 and 100 mg/kg, respectively significantly delayed the onset of diarrhea, while WFCC and EAFCC at 100 mg/kg significantly reduced the amount of wet feces output and total feces output. In addition, only WFCC and EAFCC (at 50 and 100 mg/kg, respectively) significantly reduced the mean weight of wet feces and total feces. The percentage of maximum diarrhea inhibition was observed at the EAFCC dose of 100 mg/kg. Based on the charcoal meal test results, only EAFCC significantly inhibited the distance traveled by charcoal meal and reduced the peristaltic index at a dose of 100 mg/kg, while the percentage decrease in gastrointestinal motility was 46.87%. Similarly, in the entero-pooling test, WFCC and EAFCC significantly reduced the volume and weight of intestinal contents at a dose of 100 mg/kg, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results confirm that the extract and fractions of &lt;em&gt;C. costata&lt;/em&gt; have antidiarrheal activity. Therefore, this study provides scientific support for the traditional use of &lt;em&gt;C. costata&lt;/em&gt; in treating diarrhea.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">31</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1,*&lt;/sup&gt;, Mally Ghinan Sholih&lt;sup&gt;2&lt;/sup&gt;, Nitya Nurul Fadilah&lt;sup&gt;3&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Surya Amal&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Lina Aliyani Mardiana&lt;sup&gt;1&lt;/sup&gt;, Diany Astuti&lt;sup&gt;1&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Health Sciences, Universitas Singaperbangsa Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Health Sciences, Universitas Perjuangan Tasikmalaya, Tasikmalaya, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Parellangi</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Agus Bintara Birawida</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Oedojo Soedirham</style></author><author><style face="normal" font="default" size="100%">Pawennari Hijjang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification of Family Adaptive Behavior in The Dayak Tribe in An Effort to Prevent Stroke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Family Adaptive Behavior.</style></keyword><keyword><style  face="normal" font="default" size="100%">FGD</style></keyword><keyword><style  face="normal" font="default" size="100%">Stroke</style></keyword><keyword><style  face="normal" font="default" size="100%">The Dayak Tribe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">334-338</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The Dayak tribe inhabits a large part of West Kutai Regency, East Kalimantan Province. Hypertension is a major health problem in the West Kutai region. The family plays a role as a facilitator in reducing hypertension and preventing the risk of Stroke in family members. The purpose of this study was to identify the adaptive behavior of Dayak families in an effort to prevent Stroke. This research method is qualitative research with in-depth interviews and FGD (focus group discussion). FGDs were conducted on 7 participants with tingkat 1 and tingkat 2 hypertension patients and 3 people from traditional leaders/ culturalists. This study obtained four main themes, namely 1) Understanding health problems, 2) Utilization of medicinal plants, 3) Disease control, 4) Driving factors in reducing Stroke risk. Suggestions for health workers to be able to improve educational methods and digital health promotion not only using print media.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">334</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Parellangi&lt;sup&gt;1,2,*&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;1&lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;1&lt;/sup&gt;, Agus Bintara Birawida&lt;sup&gt;1&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;1,*&lt;/sup&gt;, Oedojo Soedirham&lt;sup&gt;3&lt;/sup&gt;, Pawennari Hijjang&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Nursing, Politeknik Kesehatan Kementerian Kesehatan Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Social and Political Sciences, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Fauzan Jauhari</style></author><author><style face="normal" font="default" size="100%">Lucia Yovita Hendrati</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author><author><style face="normal" font="default" size="100%">Asra Al Fauzi</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Eko Agus Subagio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Impact of Kaempferia galanga L. Extract on Nerve Growth  Factor Expression in A Rat Model of Traumatic Brain Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">kaempferia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Nerve Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1236-1243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Head injuries contribute significantly to morbidity and mortality globally, and there is need of effective treatment. This study focuses on evaluating NGF (Nerve Growth Factor) expression in a rat model of traumatic brain injury, exploring the potential therapeutic effects of &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract. &lt;strong&gt;Methods: &lt;/strong&gt;Male Wistar rats were used in the experiment, and traumatic brain injury was induced using Marmarou's weight drop model. Four groups of rats were studied: a negative control group, a group with traumatic brain injury without &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract, and two groups with traumatic brain injury treated with different doses of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. Rats were divided further based on the time of decapitation, either 24 or 48 hours post-injury. NGF expression was assessed using immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; The study confirmed NGF expression variations among groups, with stronger expression observed 48 hours post-injury in rats receiving 1200 mg/kgbb of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. This suggests a potential impact of the extract on NGF expression, likely attributed to its anti-inflammatory and antioxidant properties. &lt;strong&gt;Discussion:&lt;/strong&gt; &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract has known anti-inflammatory and antioxidant effects, which may contribute to increased NGF expression observed in this study. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study sheds light on the potential benefits of&lt;em&gt; Kaempferia galanga L&lt;/em&gt;. extract in promoting NGF expression and improving outcomes in traumatic brain injury, emphasizing the need for further investigation to translate these findings into clinical practice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1236</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Fauzan Jauhari&lt;sup&gt;1&lt;/sup&gt; , Lucia Yovita Hendrati&lt;sup&gt;2 *&lt;/sup&gt;, Agus Turchan&lt;sup&gt;1 &lt;/sup&gt;, Asra Al Fauzi&lt;sup&gt;1&lt;/sup&gt; , Budi Utomo&lt;sup&gt;3&lt;/sup&gt; , Eko Agus Subagio&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Population Biostatistics and Health promotion, Faculty of Public Health, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurfhadila Utami Husain</style></author><author><style face="normal" font="default" size="100%">Syahrir A Pasinringi</style></author><author><style face="normal" font="default" size="100%">Fridawaty Rivai</style></author><author><style face="normal" font="default" size="100%">Noer Bahry Noor</style></author><author><style face="normal" font="default" size="100%">Khalid Saleh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Influence of Work Engagement on Job Satisfaction and Human Resource Performance in South Sulawesi Provincial Hospital 2022</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Performance.</style></keyword><keyword><style  face="normal" font="default" size="100%">Satisfaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Work engagement</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">650-654</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the most important factors for an individual to have at work is work engagement which is a concept that can reflect that an individual has passion, focus, and also strong dedication to work at the company. Work engagement is also defined as a positive and satisfying mental state related to work that is characterized by vigor, dedication, and absorption.&lt;sup&gt;1&lt;/sup&gt; An HR can be said to be work engagement when an HR is able to make his work a priority for himself and personally for the organization besides that work engagement is personal HR who are proud to have been part of an organization so that they are able to work according to the jobdesk given (Rohana Manalu et al., 2021). This study aims to analyze the effect of Work Engagement on Job Satisfaction and HR Performance at the South Sulawesi Provincial Hospital. This type of research is quantitative research using an analytic observational design with a cross sectional study approach. The sample in this study were health workers using a stratified random sampling technique of 316 people. The samples taken in this study were 152 employees at Laburan Baji Hospital, 122 Haji Hospital and 42 people at Sayang Rakyat Hospital. Data analysis used univariate, bivariate &amp;amp; path analysis. The results showed that there was a direct effect of work engagement on job satisfaction and HR performance with a coefficient of 0.525 and 0.267 for each with a p value (0.000) &amp;lt; 0.05 (significant). In addition, there is a direct effect of job satisfaction on HR performance, namely a coefficient value of 0.620 with a p value (0.000) &amp;lt;0.05. Meanwhile, the effect of work engagement on HR performance through job satisfaction obtained a coefficient value of 0.326 with a p value (0.000) &amp;lt; 0.05. which means Work Engagement has an influence on HR Performance through Job Satisfaction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">650</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurfhadila Utami Husain&lt;sup&gt;1,*&lt;/sup&gt;, Syahrir A Pasinringi&lt;sup&gt;1&lt;/sup&gt;, Fridawaty Rivai&lt;sup&gt;1&lt;/sup&gt;, Andi Indahwaty Sidin&lt;sup&gt;1&lt;/sup&gt;, Noer Bahry Noor&lt;sup&gt;1&lt;/sup&gt;, Khalid Saleh&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hospital Administration Study Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Cardiovascular Disease, Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwi Wahyu Balebu</style></author><author><style face="normal" font="default" size="100%">Ridwan Aminuddin</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Arsunan Arsin</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Herawati</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Miracle of Moringa Oleifera Leaves for the Prevention of  Anemia: A Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera leaf extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1258-1261</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Moringa oleifera&lt;/em&gt; leaves contain very rich compounds that include nutrients, minerals, vitamins, amino acids, and many other compounds with numerous benefits for humans. This literature review discusses the benefits of Moringa oleifera leaves in preventing anemia.&lt;strong&gt; Methods:&lt;/strong&gt; This review is a narrative review using the research of international journal sources from databased, national journals in the last ten years. The keywords anemia, hemoglobin, and &lt;em&gt;Moringa oleifera/M. oleifera&lt;/em&gt; leaves were used. Based on the 35 journals reviewed, 12 studies were included in this review.&lt;strong&gt; Results:&lt;/strong&gt; The literature results show a positive relationship between Moringa leaf extract and an increase in the value of hemoglobin levels, with a p-value &amp;lt;0.05. However, this review found other benefits of &lt;em&gt;Moringa oleifera&lt;/em&gt; leaf extract, such as improving the morphology of damaged red blood cells and antioxidants. It has become an alternative in the treatment of anemia. &lt;strong&gt;Conclusions:&lt;/strong&gt; The nutrient content in Moringa leaf extract plays a significant part in increasing hemoglobin levels in the blood. Other factors that can increase the risk of anemia are micronutrient deficiency, infectious diseases (HIV/AIDS, tuberculosis, and malaria), worm infections, and genetic disorders. (25) We recommend conducting an experimental study to compare two groups given Moringa leaf extract and multi-micronutrient tablets to get more effective results in lowering the prevalence of anemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1258</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwi Wahyu Balebu&lt;sup&gt;1 *&lt;/sup&gt;, Ridwan Aminuddin&lt;sup&gt;2&lt;/sup&gt; , Veni Hadju&lt;sup&gt;2&lt;/sup&gt; , Arsunan Arsin&lt;sup&gt;2&lt;/sup&gt; , Nurhaedar Jafar&lt;sup&gt;2 &lt;/sup&gt;, Herawati&lt;sup&gt;3&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Public Health Sciences, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty Of Public Health, University of Tompotika Luwuk Banggai, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Priya Nugraha</style></author><author><style face="normal" font="default" size="100%">Pramitha Nayana Librata</style></author><author><style face="normal" font="default" size="100%">Cindy Cecilia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nonmotoric Symptoms Scale (NMSS) Validity and Reliability Test in Patients with Parkinson's Disease in Dr. Soetomo General Hospital, Surabaya, Indonesia: A Questioner Validation Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nonmotoric Symptoms Scale</style></keyword><keyword><style  face="normal" font="default" size="100%">Parkinson’s disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Validation</style></keyword><keyword><style  face="normal" font="default" size="100%">Validity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">316-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Nonmotor symptoms are common but less reported in Parkinson's disease. it’s the cause of decreased quality of life and disability in many patients with Parkinson's disease compared to the motor symptom. Our study aimed to translate the original English-language version of the nonmotor symptom scale (NMSS) into the Indonesian version of the NMSS. And also to evaluate its validity and reliability for use in Indonesian-speaking Parkinson's disease patients. This for better and valid usage of NMSS scale in the Indonesian patient and health care provider &lt;strong&gt;Material and Method: &lt;/strong&gt;This was descriptive-analytic study. Cross-cultural adaptation of NMSS and psychometric analysis of the Indonesian version of NMSS was carried out from 2 Teaching Hospital centers in Surabaya, East Java. Several other scales were also examined, including MMSE, ESS, BDI, and Scopa-Aut. A reliability test was performed using Alpha Cronbach.&lt;strong&gt; Results:&lt;/strong&gt; A total of 35 patients were included in this study. the average age was 64.03±12.92 with the female sex 42.9% (n=15) and the male 57.1% (n=20), and Hoehn and Yahr stage II 57.1% (n=20). The total average NMSS is 11.64. The validity of contents and constructs of the NMSS on each domain has been proven valid. Internal reliability of internal consistency in these tools with an alpha Cronbach value of 0.836. Each domain correlates with several other scores including MMSE, BDI, ESS, and Scopa-aut. &lt;strong&gt;Conclusion:&lt;/strong&gt; The Indonesian version of NMSS has good validity and reliability in assessing nonmotor symptoms in Parkinson's disease patients in Indonesia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">316</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Hamdan*, Priya Nugraha, Pramitha Nayana Librata, Cindy Cecilia&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Airlangga University – Dr. Soetomo General Academic Teaching Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tatik Hernawati</style></author><author><style face="normal" font="default" size="100%">Tita Damayanti Lestari</style></author><author><style face="normal" font="default" size="100%">Suzanita Utama</style></author><author><style face="normal" font="default" size="100%">Rimayanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Optimization of Osteopontin Recombinant Protein as a Candidate Supplementation for Semen Preservation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DNA clone</style></keyword><keyword><style  face="normal" font="default" size="100%">Osteopontin</style></keyword><keyword><style  face="normal" font="default" size="100%">PCR amplification.</style></keyword><keyword><style  face="normal" font="default" size="100%">Primer</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">668-673</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The recombinant protein of heterologous proteins in&lt;em&gt; Escherichia coli&lt;/em&gt; strains K12 has various and different systems tested and demands a detailed insight into the multiple factors affecting the encoded protein. One of the crucial factors is the acceptable quality of the DNA copies inserted inside the bacteria. Firstly, the amplification procedure needed to be performed well; thus, designing the primer and selecting the optimum annealing temperature are the focus indicators in this study. This study obtained a reference gene from the NCBI data bank with Reference Sequence: NM_174187.2. Two types of primers (SPP1FSPP1R and OPN1F - OPN1R) with different targeted bands were designed and selected after being reconstructed using the software. Online software such as addgene.org is also used to identify the right restriction site. The annealing temperature distinguished the PCR system used to amplify each primer. The result of this study revealed the best annealing at 65ºC successfully amplified 820 bp of the targeted band. The phenomenon not following the theory of blue-white screening is the empty plasmid control, where not a single colony grows on the media. Competent cells inserted with empty plasmids should still be able to expand on LB-Amp agar media because the presence of these plasmids is capable of providing resistance to antibiotics (in this case, ampicillin). This discrepancy is thought to have been caused by the improper insertion of the empty plasmid so that the plasmid did not enter the competent cell.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">668</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tatik Hernawati*, Tita Damayanti Lestari, Suzanita Utama, Rimayanti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Departement of Veterinary Reproduction, Faculty of Veterinary Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rubiati Hipni</style></author><author><style face="normal" font="default" size="100%">Isnaniah</style></author><author><style face="normal" font="default" size="100%">Noorhayati Maslani</style></author><author><style face="normal" font="default" size="100%">Hapisah</style></author><author><style face="normal" font="default" size="100%">Megawati</style></author><author><style face="normal" font="default" size="100%">Isrowiyatun Daiyah</style></author><author><style face="normal" font="default" size="100%">Ahmad Rizani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Activity in Dragon Fruit  Plant Extracts as Immunomodulators in Pregnant Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Dragon fruit plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant  Women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">999-1004</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dragon fruit contains many organic acids, proteins, and minerals such as potassium, magnesium, calcium, iron, and vitamin C. Several natural compounds can increase the activity of the immune system, namely flavonoids, curcumin, limonoids, vitamin C, vitamin E, and catechins. &lt;strong&gt;Objective: &lt;/strong&gt;to analyze the levels of phytochemicals and active ingredients from the fruit, skin, stem, and roots of dragon fruit plants. &lt;strong&gt;Methods: &lt;/strong&gt;This research was carried out experimentally, carried out at the Pucuk Sirih Jamu Factory. This study used fresh and ripe Dragon Fruit Plants directly taken from the Tanah Laut District garden (South Kalimantan), carried out extract preparation, phytochemical screening, and determination of phytochemical levels of red dragon fruit plants. &lt;strong&gt;Results: &lt;/strong&gt;The study found the highest secondary metabolite levels in red dragon fruit for Flavonoids in the stem (0.74%), Alkaloids in the stem (4.21%), Saponins in fruit flesh (0.45%), and Steroids in roots (2.54%). Antioxidant activity in red dragon fruit flesh (78.23%), stem (79.13%), root (8.64%), and skin (11.24%). The highest antioxidant activity in red dragon fruit stems.&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; There are groups of secondary metabolites and antioxidants contained in dragon fruit plants (fruit, skin, stems, and roots) from Kalimantan Selatan (Indonesia).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">999</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rubiati Hipni*, Isnaniah, Noorhayati Maslani, Hapisah, Megawati, Isrowiyatun Daiyah, Ahmad Rizani&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Midwifery Department of Politeknik Kemenkes Banjarmasin, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dian Iriani</style></author><author><style face="normal" font="default" size="100%">Bustari Hasan</style></author><author><style face="normal" font="default" size="100%">N Ira Sari</style></author><author><style face="normal" font="default" size="100%">Vivi Alfionita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preparation of Face Mask from Microalga Chlorella sp. and Its Potential as Antiaging</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiaging</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorella sp</style></keyword><keyword><style  face="normal" font="default" size="100%">Face mask.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">112-118</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The mask with natural extracts is more acceptable by consumers at present. The &lt;em&gt;Chlorella&lt;/em&gt; sp. is one of the microalgae which contain the antioxidant compound. The research aimed to obtain the best concentration of &lt;em&gt;Chlorella&lt;/em&gt; sp. in the manufacturing of masks and to evaluate the sensory, physical properties, chlorophyll a b, carotenoid and its antioxidant compound. Non-factorial Completely Randomized Design with 4 level treatments was used in this study with different concentrations of &lt;em&gt;Chlorella&lt;/em&gt; sp. powder whereas MW&lt;sub&gt;0&lt;/sub&gt; (without chlorella powder), MW&lt;sub&gt;1&lt;/sub&gt; (0.4% chlorella powder), MW&lt;sub&gt;2&lt;/sub&gt; (0.5% chlorella powder), MW&lt;sub&gt;3&lt;/sub&gt; (0.6% chlorella powder), triplicated. The parameter assay was observed for sensory (color, texture, and odor), physical properties (homogeneity, pH, spreadability, drying time), chlorophyll a, b, carotenoid and antioxidant activity. Based on the result of this study shows that the MW&lt;sub&gt;3&lt;/sub&gt; with 0.6% of chlorella powder was the best treatment with sensory value (8.28, 7.08, 7.37); physical properties (homogenous, 5.3, 7.5 cm, 24-30 minutes), respectively. Meanwhile, chlorophyll a 0.67 mg/L, chlorophyll b 0.89 mg/L, total chlorophyll 1.63 mg/L, carotenoid 0.84 mg/L, the antioxidant activity of Chlorella sp. mask was 246.70 mg/L. Therefore, the present study suggested that the Chlorella sp. mask could be used in cosmeceutical products, and potentially as an antiaging.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">112</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Dian Iriani*, Bustari Hasan, N Ira Sari, Vivi Alfionita&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Fisheries Products Technology, Faculty of Fisheries and Marine Science Universitas Riau, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meilla Dwi Andrestian</style></author><author><style face="normal" font="default" size="100%">Meitria Syahadatina Noor</style></author><author><style face="normal" font="default" size="100%">Resa Ana Dina</style></author><author><style face="normal" font="default" size="100%">Ayunina Rizky Ferdina</style></author><author><style face="normal" font="default" size="100%">Zulfiana Dewi</style></author><author><style face="normal" font="default" size="100%">Niken Widyastuti Hariati</style></author><author><style face="normal" font="default" size="100%">Purnawati Hustina Rachman</style></author><author><style face="normal" font="default" size="100%">Muhammad Irwan Setiawan</style></author><author><style face="normal" font="default" size="100%">Windy Tri Yuana</style></author><author><style face="normal" font="default" size="100%">Ali Khomsan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Qualitative Study on Adolescent Marriage and The Risk of  Stunting in South Kalimantan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent marriage</style></keyword><keyword><style  face="normal" font="default" size="100%">Qualitative investigation</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword><keyword><style  face="normal" font="default" size="100%">Toddler feeding pattern</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1016-1023</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; An exploratory qualitative investigation to determine the causes of adolescent marriage, analyze the effect of early marriage on stunting, and analyze the food patterns of toddlers in adolescent marriage in South Kalimantan, Indonesia.&lt;strong&gt; Method:&lt;/strong&gt; The method used is phenomenology using the FGD system and in-depth interviews. Participants include the FGD informants from the Family Planning Regional Apparatus Organization, the Office of Women's Empowerment and Child Protection and the Office of Religious Affairs from 13 Regencies/ Cities in South Kalimantan. In-depth interview informants were adolescent marriage offenders and their parents, adolescent pregnant women, midwives, integrated health service post cadres, and community leaders each taken from three Regencies/ Cities. &lt;strong&gt;Results: &lt;/strong&gt;There are not many formal adolescent marriages because they have to get a recommendation from the Religious Courts. Adolescent marriages mostly occur through informal marriages. The high rate of early marriage in South Kalimantan Province is caused by culture and weak enforcement of the rules. The incidence of adolescent marriage is caused by promiscuity and information. Meanwhile, adolescent marriage is mostly due to economic motives and limited education facilities in rural areas. Adolescent marriage is not closely related to the incidence of stunting, but low education can be a factor in the inability of parents to provide good parenting, especially feeding pratice. &lt;strong&gt;Conclusions:&lt;/strong&gt; Adolescent marriages appear to be triggered by economic motives and teenagers' desires, as well as driven by economic conditions, social influences, and a lack of encouragement to complete formal education. It was observed that stunting is more common among toddlers with adolescent mothers than toddlers with adult mothers. There is a poor feeding parenting pattern of toddlers with adolescent parents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1016</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meilla Dwi Andrestian&lt;sup&gt;1,&lt;/sup&gt;*, Meitria Syahadatina Noor&lt;sup&gt;2&lt;/sup&gt; , Resa Ana Dina&lt;sup&gt;3&lt;/sup&gt; , Ayunina Rizky Ferdina&lt;sup&gt;4&lt;/sup&gt; , Zulfiana Dewi&lt;sup&gt;5&lt;/sup&gt; , Niken Widyastuti Hariati&lt;sup&gt;6&lt;/sup&gt; , Purnawati Hustina Rachman&lt;sup&gt;7&lt;/sup&gt; , Muhammad Irwan Setiawan&lt;sup&gt;8&lt;/sup&gt; , Windy Tri Yuana&lt;sup&gt;9&lt;/sup&gt; , Ali Khomsan&lt;sup&gt;10&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;National Research and Innovation Agency, Bogor, West Jawa, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;National Research and Innovation Agency, Bogor, West Jawa, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aldila Pratiwi</style></author><author><style face="normal" font="default" size="100%">Martono Tri Utomo</style></author><author><style face="normal" font="default" size="100%">Risa Etika</style></author><author><style face="normal" font="default" size="100%">Kartika Darma Handayani</style></author><author><style face="normal" font="default" size="100%">Dina Angelika</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Relationship Between Enteral and Parenteral Nutrition on Body Weight, Incidence of NEC, Sepsis and Length of Care for Preterm Infant in Dr. Soetomo General Hospital Surabaya</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enteral</style></keyword><keyword><style  face="normal" font="default" size="100%">Hospitalization.</style></keyword><keyword><style  face="normal" font="default" size="100%">Neonatal sepsis</style></keyword><keyword><style  face="normal" font="default" size="100%">Parenteral nutrition</style></keyword><keyword><style  face="normal" font="default" size="100%">Preterm infant</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">86-89</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The incidence of preterm birth in Indonesia still accounts for the highest mortality rate. Failure to provide adequate nutrition will have an impact on growth failure, risk of infection and longer duration of care for preterm infant. This study aims to analyzing the relationship between enteral and parenteral nutrition on body weight, the incidence of NEC, the incidence of sepsis and the length of care at Dr. Soetomo Hospital Surabaya. A total 106 subjects were enrolled, 78 infants were LBW, 19 infants were VLBW. Gestational age between 32-&amp;lt;37 weeks as many as 96 subjects. 68 infants were female. A total of 49 patients (46.2%) received parenteral nutrition. There is a relationship between enteral nutrition and the incidence of sepsis (p= 0.03), parenteral nutrition and body weight (p= 0.005), parenteral nutrition and the incidence of sepsis (p= 0.001), and parenteral nutrition and the length of care for preterm infants (p= 0.001). There is a relationship between enteral nutrition with the incidence of sepsis and parenteral nutrition with body weight, incidence of sepsis and length of care in preterm infants.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">86</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Aldila Pratiwi*, Martono Tri Utomo, Risa Etika, Kartika Darma Handayani, Dina Angelika&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pediatrics, Faculty of Medicine, Universitas Airlangga, 60132, Surabaya, East Java/Dr. Soetomo General Hospital, 60286, Surabaya, East Java, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Putri Ayuni Alayyannur</style></author><author><style face="normal" font="default" size="100%">Dani Nasirul Haqi</style></author><author><style face="normal" font="default" size="100%">Fatimatuz Zahroh</style></author><author><style face="normal" font="default" size="100%">Tazkia Azrielda Munib</style></author><author><style face="normal" font="default" size="100%">Moh. Malik Alhakim</style></author><author><style face="normal" font="default" size="100%">Diah Pramesthi Ningrum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Relationship Between Individual Characteristics and the Risk of Exposure to Heat Stress in Indonesian Fishermen</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Age</style></keyword><keyword><style  face="normal" font="default" size="100%">Exercise Habits</style></keyword><keyword><style  face="normal" font="default" size="100%">Heat Stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Water Drinking Consumption.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">294-297</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Fishermen who go to sea during the day are classified as informal sector jobs that have heavy activities and are at risk of becoming dehydrated because the work climate is in a hot environment due to exposure to sunlight.&lt;strong&gt; Objective: &lt;/strong&gt;The purpose of this study was to analyze the relationship between individual characteristics and the risk of heat stress exposure to fishermen in Surabaya Coastal Area. &lt;strong&gt;Materials and&lt;/strong&gt; &lt;strong&gt;Methods:&lt;/strong&gt; This research is a cross sectional study with a sample of 100 people using accidental sampling technique. The research was conducted in the Surabaya Coastal Area from February to June 2022. The variables of this study include age, exercise habits, water drinking consumption, and risk of heat stress. The relationship analysis test used Spearman correlation and chi square. Results: Based on cross tabulation, the age interval that experienced the most heat stress was 41-50 years of age, followed by 51-60 years of age group. Respondents who exercise more are at risk of heat stress than respondents who do not exercise. Workers who consume 1-2 liters of water per day are the group that has the highest risk of heat stress. &lt;strong&gt;Conclusion&lt;/strong&gt;: No one variable has a relationship with the risk of heat stress exposure to fishermen in Surabaya, but it is still important to increase the consumption of fisherman's water and doing exercise habits among fishermen in Surabaya.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">294</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Putri Ayuni Alayyannur&lt;sup&gt;1,*&lt;/sup&gt;, Dani Nasirul Haqi&lt;sup&gt;1&lt;/sup&gt;, Fatimatuz Zahroh&lt;sup&gt;2&lt;/sup&gt;, Tazkia Azrielda Munib&lt;sup&gt;2&lt;/sup&gt;, Moh. Malik Alhakim&lt;sup&gt;3&lt;/sup&gt;, Diah Pramesthi Ningrum&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Lecturer of Department of Occupational Safety and Health, Faculty of Public Health, Universitas Airlangga, Campus C, Mulyorejo, 60115, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student of Bachelor Degree, Faculty of Public Health, Universitas Airlangga, Campus C, Mulyorejo, 60115, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Student of Bachelor Degree, Faculty of Dentistry, Universitas Airlangga, Campus A, Mayjen Prof. Dr. Moestopo Street No.47, 60132, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Employee of Health Office of Tapin District, Pembangunan Street No. 14, 71111, North Tapin, Tapin, South Kalimantan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rangki Astiani</style></author><author><style face="normal" font="default" size="100%">Mohamad Sadikin</style></author><author><style face="normal" font="default" size="100%">Aprilita Rinayanti</style></author><author><style face="normal" font="default" size="100%">Wawaimuli Arozal</style></author><author><style face="normal" font="default" size="100%">Ani Retno Prijanti</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Firdayani Firdayani</style></author><author><style face="normal" font="default" size="100%">Piter Piter</style></author><author><style face="normal" font="default" size="100%">Guntoro Halim</style></author><author><style face="normal" font="default" size="100%">Franciscus D. Suyatna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Triterpene Saponin Compounds from Centella asitica as Renin Inhibitor with Pharmacophore Modeling, Molecular Docking and In-vitro Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihypertensive.</style></keyword><keyword><style  face="normal" font="default" size="100%">Asiaticoside</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">In-vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Madecasoside</style></keyword><keyword><style  face="normal" font="default" size="100%">Renin inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">57-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Hypertension is a silent killer that causes kidney, heart, and stroke damage if not handled properly. In Indonesia, the prevalence of the population with high blood pressure is 34.11% with women 36.85% higher than men 31.34%, this shows a fairly high value so that special attention is needed on hypertension therapy. It is known that currently there are 6 types of pharmacological therapy for hypertension and one of the newest is the renin inhibitor class (Aliskiren). Indonesia has diverse natural wealth in the form of flora and fauna, with a wealth of more than 30,000 types of medicinal plants with 9500 potential herbal medicines that have not been utilized optimally, with the largest exporter of herbal medicines in the world. &lt;em&gt;Centella asiatica&lt;/em&gt; plants containing triterpenoid saponins have high renin inhibitor activity, namely the content of Asiaticoside and Madecasoside. The research method was carried out &lt;em&gt;in silico&lt;/em&gt; using molecular simulation and &lt;em&gt;in vitro &lt;/em&gt;with fluorometry (328/552 nm) to test the activity of asiaticoside and madecasoside compounds as well as a mixture of asiaticoside and madecasoside in &lt;em&gt;Centella asiatica&lt;/em&gt; plants. This is supported by the docking outcome. The docking results show that madecososide compounds have a gibbs energy close to the positive control aleskiren (-8.356 kcal/mol) and aleskiren (-9.44 kcal/mol). The experiment results showed that the triterpenoid saponin compound (madecassoside) contained an IC value of 0.71, at a concentration of 5 μg/μl, and absorbance of 1.35 A in the first minute. The strongest renin inhibition was Madecasoside compound with a concentration of 5 μg/μl with an average value of fluorescent adsorption and an average percent inhibition of 135% with the best renin inhibition at Madecasoside 5 ug/ul the first minute with absorbance values 1.19 A. Finally, the &lt;em&gt;in silico&lt;/em&gt; result corresponded to the &lt;em&gt;in vitro&lt;/em&gt; experiment. &lt;em&gt;Centella asiatica&lt;/em&gt; plants have renin inhibitor activity as antihypertensive, especially in secondary metabolites of triterpene saponins with pure madecasoside compounds compared with aliskiren as a renin inhibitor. So that the compound madecasoside has renin inhibitor activity as an antihypertensive.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">57</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rangki Astiani&lt;sup&gt;1,3,*&lt;/sup&gt;, Mohamad Sadikin&lt;sup&gt;1,2&lt;/sup&gt;, Aprilita Rinayanti&lt;sup&gt;4&lt;/sup&gt;, Wawaimuli Arozal&lt;sup&gt;1,5&lt;/sup&gt;, Ani Retno Prijanti&lt;sup&gt;1,2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,6,7&lt;/sup&gt;, Firdayani Firdayani&lt;sup&gt;8&lt;/sup&gt;, Piter Piter&lt;sup&gt;3&lt;/sup&gt;, Guntoro Halim&lt;sup&gt;3&lt;/sup&gt;, Franciscus D. Suyatna&lt;sup&gt;1,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia 10320, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology Molecular and Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10320, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas 17 Agustus 1945 Jakarta, Indonesia 14350, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy Faculty of Health Sciences, Universitas Esa Unggul, Jakarta 11510, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Technology Assesment and Application Agency (BPPT), Indonesian Science and Technology Research Center, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Himyatul Hidayah</style></author><author><style face="normal" font="default" size="100%">Surya Amal</style></author><author><style face="normal" font="default" size="100%">Nia Yuniarsih</style></author><author><style face="normal" font="default" size="100%">Farhamzah</style></author><author><style face="normal" font="default" size="100%">Anggun Hari Kusumawati</style></author><author><style face="normal" font="default" size="100%">Neni Sri Gunarti</style></author><author><style face="normal" font="default" size="100%">Ermi Abriyani</style></author><author><style face="normal" font="default" size="100%">Iin Lidia Putama Mursal</style></author><author><style face="normal" font="default" size="100%">Adinda Khansa Sundara</style></author><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sun Protection Factor Activity of Jamblang Leaves Serum Extract (Syzygium cumini)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Sun protection factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultraviolet.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">134-140</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The development of serum preparations containing natural ingredients for sun protection is growing rapidly. Jamblang (&lt;em&gt;Syzygium cumini&lt;/em&gt;) leaves are rich in phenolic compounds that can inhibit free radicals causing premature aging. Therefore, this study aims to determine the potential of &lt;em&gt;S. cumin&lt;/em&gt;i serum extract as sun protection. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was prepared and included in the serum base. The formulations were evaluated for rheological, pH, dispersion coefficient, and stability examinations. Furthermore, Sun Protection Factor was tested using a UV-Vis spectrophotometer. &lt;strong&gt;Results: &lt;/strong&gt;The test of phytochemical compounds showed the presence of alkaloids, flavonoids, polyphenols, tannins, saponins, quinones, monoterpenoids, sesquiterpenoids, triterpenoids, and steroids. The result also showed that all serum formulations met the predetermined requirements. Furthermore, the extract has protective activity against ultraviolet rays, which was indicated by the SPF value. The higher the dose of &lt;em&gt;S. cumini&lt;/em&gt; extracts in the serum formulation, the higher the value obtained. Formulations 1, 2, and 3 have SPF of 9.35±0.11, 13.26±0.16, and 26.05±0.31, respectively. This indicates that they all met the Indonesian National Standard, that a sun protection preparation must have a minimum protection factor of 4. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;S. cumini&lt;/em&gt; extract serum has the potential to be developed as a new sun protection agent against ultraviolet radiation. However, further studies are still needed to determine the mechanism of its constituent active compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">134</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Himyatul Hidayah&lt;sup&gt;1&lt;/sup&gt;, Surya Amal&lt;sup&gt;1&lt;/sup&gt;, Nia Yuniarsih&lt;sup&gt;1&lt;/sup&gt;, Farhamzah&lt;sup&gt;1&lt;/sup&gt;, Anggun Hari Kusumawati&lt;sup&gt;1&lt;/sup&gt;, Neni Sri Gunarti&lt;sup&gt;1&lt;/sup&gt;, Ermi Abriyani&lt;sup&gt;1&lt;/sup&gt;, Iin Lidia Putama Mursal&lt;sup&gt;1&lt;/sup&gt;, Adinda Khansa Sundara&lt;sup&gt;2&lt;/sup&gt;, Maulana Yusuf Alkandahri&lt;sup&gt;1,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Student of Pharmacy, Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Wilfredo Bulege-Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Luz Alexandra Javier-Silva</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre- Meza</style></author><author><style face="normal" font="default" size="100%">Victor Guillermo Sanchez-Araujo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Julia Melgar-Merino</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tanacetum Parthenium (L.) Sch Bip From Peru: Antioxidant Profile and The Antinociceptive Effect in An Experimental Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Tanacetum parthenium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">435-437</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Tanacetum parthenium&lt;/em&gt; (L.) Sch Bip known as “santa maría” (&lt;em&gt;Asteraceae&lt;/em&gt; family) is used in Peru for inflammatory diseases and also in colic, stomachache, headaches, diarrhea, among other. &lt;strong&gt;Objective:&lt;/strong&gt; The aim was to determine the antioxidant profile, and analgesic effect of ethanolic extract of flowers and leaves of &lt;em&gt;T. parthenium &lt;/em&gt;&lt;strong&gt;Material and Methods:&lt;/strong&gt; Leaves and flowers of &lt;em&gt;T. parthenium&lt;/em&gt; were soaked in 96% ethanol and the obtained extract was analyzed using chemical reactions for identifying each secondary metabolite, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) was used to determine the antioxidant capacity, and the antinociceptive effect was determined by using tail flick method.&lt;strong&gt; Results:&lt;/strong&gt; Qualitative phytochemical study indicates the presence phenolic compounds, alkaloids, flavonoids, saponins and steroids in both extracts. In DPPH assay IC&lt;sub&gt;50 &lt;/sub&gt;showed in leaves and flowers extract 452.10 ± 10.2 μg/mL and 270.70 ± 20.6 μg/mL respectively. The antinociceptive effect was better in leaves at doses 300 mg/ Kg than flower extract. &lt;strong&gt;Conclusions:&lt;/strong&gt; The ethanolic extract of flowers of &lt;em&gt;T. parthenium &lt;/em&gt;showed a high antioxidant activity and antinociceptive effect in mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Wilfredo Bulege-Gutiérrez&lt;sup&gt;2&lt;/sup&gt;, Luz Alexandra Javier-Silva&lt;sup&gt;3&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;4&lt;/sup&gt;, Victor Guillermo Sanchez-Araujo&lt;sup&gt;5&lt;/sup&gt;, Elizabeth Julia Melgar-Merino&lt;sup&gt;6&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;7&lt;/sup&gt;, José Santiago Almeida-Galindo&lt;sup&gt;8&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;9&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universidad Privada del Norte, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Peruana Los Andes, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Universidad Nacional de Huancavelica, PERU. 6Department of Chemical Sciences, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Human Medicine, Faculty of Health Science, Universidad Nacional de San Cristobal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Chemistry Pharmaceutical, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darmin Dina</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Veny Hadju</style></author><author><style face="normal" font="default" size="100%">Hasnawati Amqam</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Yulianah Sulaiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Why Preconception Treatment is Important? A Literature Reviews</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron status</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1262-1267</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Conceptional care is a concept that has been proposed to address maternal health problems and environmental risk factors during pregnancy to improve the health of both mother and fetus during pregnancy. This article provides an overview of several studies relating to preconception care that are useful for preparing for a healthy pregnancy and fetus. &lt;strong&gt;Methods: &lt;/strong&gt;This narrative review uses several sources from the Elsevier database. Key search terms such as preconception, iron status, pregnancy and fetus were used in this review. Of the 50 studies identified, 20 were eligible for inclusion in this review. &lt;strong&gt;Results:&lt;/strong&gt; Preconception care is getting an increased focus as an effective way to prevent complications during pregnancy, childbirth, and postpartum as well as preventing fetal abnormalities by estimating nutritional status in the preconception period. Preconception care is aimed at supporting the health of women before pregnancy, which is useful for improving the health of a pregnancy and preventing stunted fetal growth due to poor nutritional status in the mother. Low preconception iron status will have an impact on preconception gynecological morbidity, which will cause complications in pregnancy and cause low birth weight. &lt;strong&gt;Conclusion:&lt;/strong&gt; Preconception care when given regularly will affect the health of a pregnancy and the baby when born. Preconception care teaches women of reproductive age to minimize potential health risks from an early age so that if they have a baby, the baby is born in better health. Considering that a healthy baby is very late if it is prepared during pregnancy but must be prepared from the preconception period, that is why preconception is so important.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1262</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darmin Dina&lt;sup&gt;1,2,*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt; , Veny Hadju&lt;sup&gt;3&lt;/sup&gt; , Hasnawati Amqam&lt;sup&gt;4&lt;/sup&gt; , Wahiduddin&lt;sup&gt;4&lt;/sup&gt; , Ridwan Amiruddin&lt;sup&gt;5&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt; , Yulianah Sulaiman&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;STIKES Bina Bangsa Majene, West Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition Department Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Health Department Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Epidemiology Department, Hasanuddin University, INDONESIA. 6 STIKES Bina Bangsa Majene, West Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A Ismail</style></author><author><style face="normal" font="default" size="100%">TAFT Anuar</style></author><author><style face="normal" font="default" size="100%">IFM Suffian</style></author><author><style face="normal" font="default" size="100%">AA Abdul Hamid</style></author><author><style face="normal" font="default" size="100%">MN Omar</style></author><author><style face="normal" font="default" size="100%">BE Mustafa</style></author><author><style face="normal" font="default" size="100%">WAN Wan Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Angiotensin Converting Enzyme (ACE) Inhibition Activity by Syzygium polyanthum Wight (Walp.) Leaves: Mechanism and Specificity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">76-84</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the potential antihypertensive mechanisms include angiotensin converting enzyme (ACE) inhibition. So far, there is no in-depth study on the ACE inhibition activity of &lt;em&gt;S. polyanthum&lt;/em&gt;, an ethnomedicinal plant used in treating hypertension. Thus, we aimed to study the ACE inhibition activity of&lt;em&gt; S. polyanthum&lt;/em&gt; leaves by evaluating its potency, mechanism, and specificity.&lt;strong&gt; Methods: &lt;/strong&gt;&lt;em&gt;S. polyanthum&lt;/em&gt; leaves were macerated in a bath-sonicator with either water, methanol, ethyl acetate, and hexane producing aqueous (ASP), methanolic (MSP), ethyl acetate (EASP) and hexane (HSP) extracts. Each extract (100 μg/mL) were initially screened for ACE inhibition activity and then compared with standard drug, captopril (2.06 ng/mL), then the most active extract was further tested at 1 to 1000μg/ml. Inhibition mechanism was studied using zinc chloride and bovine serum albumin (BSA), while inhibition specificity was determined upon screening for α-chymotrypsin and trypsin inhibition activity. &lt;strong&gt;Results:&lt;/strong&gt; ASP at 100 μg/ mL exhibited the highest inhibition activity (69.43 ± 0.60 %) compared to MSP (41.63 ± 0.15 %), EASP (9.62 ± 1.60 %), and HSP (45.40 ± 0.15 %). ASP showed dose-dependent ACE inhibition activity with IC&lt;sub&gt;50&lt;/sub&gt; of 41 μg/mL. ASP’s ACE inhibition activity was significantly reduced in the presence of BSA, but not upon the presence of zinc chloride. ASP did not significantly inhibit α-chymotrypsin and trypsin. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study showed that the enzyme inhibition activity by&lt;em&gt; S. polyanthum &lt;/em&gt;leaves was specific towards ACE. The ACE inhibition possibly occurs via protein precipitation and was non-dependent to the chelation with zinc at ACE active site.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;Antihypertensive, ACE, Angiotensin converting enzyme, Hypertension, Syzygium polyanthum&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">76</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;A Ismail&lt;sup&gt;1,*&lt;/sup&gt;, TAFT Anuar&lt;sup&gt;2&lt;/sup&gt;, IFM Suffian&lt;sup&gt;3&lt;/sup&gt;, AA Abdul Hamid&lt;sup&gt;4&lt;/sup&gt;, MN Omar&lt;sup&gt;4&lt;/sup&gt;, BE Mustafa&lt;sup&gt;1&lt;/sup&gt;, WAN Wan Ahmad&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fundamental Dental and Medical Sciences, Kulliyah of Dentistry, International Islamic University Malaysia, 25200 Kuantan, Pahang, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, 25200 Kuantan, Pahang, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia, 25200 Kuantan, Pahang, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biomedicine Programme, School of Health Sciences, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">KA Radzun</style></author><author><style face="normal" font="default" size="100%">MHH Rusmidi</style></author><author><style face="normal" font="default" size="100%">Aini</style></author><author><style face="normal" font="default" size="100%">I Norisam</style></author><author><style face="normal" font="default" size="100%">N Iran</style></author><author><style face="normal" font="default" size="100%">F Pardi</style></author><author><style face="normal" font="default" size="100%">A Ismail</style></author><author><style face="normal" font="default" size="100%">WRWA Razak</style></author><author><style face="normal" font="default" size="100%">SRA Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Effects of Astaxanthin Extracted from Microalgae Hematococcus pluvialis and Combinations with Palm Tocotrienol Rich-Fraction in RAW 264.7 Macrophages</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">205-215</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Astaxanthin and tocotrienols, known as antioxidants derived from natural compounds and shown to have anti-inflammatory properties. This study aims to investigate the effects of a combination of astaxanthin extracted from&lt;em&gt; Hematococcus pluvialis&lt;/em&gt; microalga and palm tocotrienols rich-fraction (TRF) on inflammatory reaction in lipopolysaccharide (LPS)-stimulated mouse RAW 264.7 macrophages cells. MTT assay was used to test cell viability and nitrite oxide (NO) was determined using Griess assay. Isobologram confirmed that the combined treatment produced synergistic effect and measurement of inflammatory cytokines such as interleukin 6 (IL-6) and interleukin 12 (IL-12) through ELISA assay. Our results showed that the combination of astaxanthin and TRF exhibited inflammatory markers such as NO production. The concentration of astaxanthin ranging from 10 to 100 μg/mL and TRF at 4-25 μg/mL had no toxicity and achieved higher cell viability. The combination treatments led to more potent inhibition of NO production compared to single treatments. Combination Index (CI) was achieved from the combination treatments at IC80, resulting in synergism at a CI value of 0.81. Furthermore, ELISA showed that the combined treatment significantly further reduced the expression levels of pro-inflammatory cytokines IL-6 and IL-12. Our findings suggest that the combination of astaxanthin and TRF enhanced anti-inflammatory and antioxidant activities in stimulated macrophages and may act synergistically to produce health effects reducing inflammation.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key Words: &lt;/strong&gt;Inflammation, Tocotrienol-Rich Fraction, Astaxanthin, Antioxidant, Combination, Macrophages&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">205</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;KA Radzun&lt;sup&gt;1,*&lt;/sup&gt;, MHH Rusmidi&lt;sup&gt;1&lt;/sup&gt;, MAM Aini&lt;sup&gt;2&lt;/sup&gt;, I Norisam&lt;sup&gt;2&lt;/sup&gt;, N Iran&lt;sup&gt;2&lt;/sup&gt;, F Pardi&lt;sup&gt;1,3&lt;/sup&gt;, A Ismail&lt;sup&gt;1&lt;/sup&gt;, WRWA Razak&lt;sup&gt;1&lt;/sup&gt;, SRA Hafid&lt;sup&gt;2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Malaysian Palm Oil Board, No.6 Persiaran Institusi, Bandar Baru Bangi, Kajang Selangor D.E, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute for Biodiversity and Sustainable Development, Universiti Teknologi MARA, 40450, Selangor, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rina Hidayati Pratiwi</style></author><author><style face="normal" font="default" size="100%">Eva Oktarina</style></author><author><style face="normal" font="default" size="100%">Wibowo Mangunwardoyo</style></author><author><style face="normal" font="default" size="100%">Iman Hidayat</style></author><author><style face="normal" font="default" size="100%">Endang Saepudin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial Compound from Endophytic Pseudomonas azotoformans UICC B-91 of Neesia altissima (Malvaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">172-181</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Centrifugated extract of endophytic &lt;em&gt;Pseudomonas azotoformans&lt;/em&gt; strain UICC B-91 has been observed for its antimicrobial activity against Escherichia coli ATCC 8739,&lt;em&gt; Bacillus cereus &lt;/em&gt;ATCC 10876, &lt;em&gt;Staphylococcus aureus &lt;/em&gt;ATCC 6583, Staphylococcus aureus ATCC 25923,&lt;em&gt; Salmonella typhimurium&lt;/em&gt; ATCC 25241, &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; ATCC 15442, &lt;em&gt;Bacillus subtilis&lt;/em&gt; ATCC 19659 and &lt;em&gt;Candida albicans&lt;/em&gt; ATCC 10231, with minimum concentration in the range 250 μg/mL. But, the novel compound of the bioactive substances which relevant for antimicrobial activity have not been described. Further fractionation and identification of the extract by thin layer chromatography (TLC) and liquid chromatography mass spectrophotometry (LCMS-MS) detected several compound as futoamide (C&lt;sub&gt;18&lt;/sub&gt;H&lt;sub&gt;23&lt;/sub&gt;NO&lt;sub&gt;3&lt;/sub&gt;), gentialutine (C9H11NO), gentiabetine (C&lt;sub&gt;9&lt;/sub&gt;H&lt;sub&gt;11&lt;/sub&gt;NO2), 1-[(2E,4E)-2,4-decadienoyl]pyrrolidine (C&lt;sub&gt;14&lt;/sub&gt;H&lt;sub&gt;23&lt;/sub&gt;NO), lycopodine (C&lt;sub&gt;16&lt;/sub&gt;H&lt;sub&gt;25&lt;/sub&gt;NO) and dihydrolycopodine (C&lt;sub&gt;16&lt;/sub&gt;H&lt;sub&gt;27&lt;/sub&gt;NO). The majority compounds containing CHON elements with molecular weight approximately 100-450 Da.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt; Alkaloid, Antimicrobial compound, Extraction, P. azotoformans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">127</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rina Hidayati Pratiwi&lt;sup&gt;1,2,*&lt;/sup&gt;, Eva Oktarina&lt;sup&gt;3&lt;/sup&gt;, Wibowo Mangunwardoyo&lt;sup&gt;4&lt;/sup&gt;, Iman Hidayat&lt;sup&gt;5&lt;/sup&gt;, Endang Saepudin&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Mathematics and Natural Sciences Education, Faculty of Post Graduated, Universitas Indraprasta PGRI, South Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biological Education, Faculty of Mathematics and Natural Sciences, Universitas Indraprasta PGRI, East Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Master Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Biomaterial, Indonesian Institute of Sciences (LIPI), Cibinong, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidants, Total Phenolic and Flavonoid Content and Toxicity Assay of Ampelas (Tetracera macrophylla Wall.Ex Hook.F.&amp; Thoms) From Kalimantan-Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetracera macrophylla</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">642-648</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: High Reactive Oxygen Species (ROS) contribute to disease pathogenesis. Phenolic compounds and flavonoids are effective as antioxidants. &lt;strong&gt;Objective: &lt;/strong&gt;This research aimed to measure the antioxidant activity, total phenolic and flavonoid content and leaf toxicity of&lt;em&gt; Tetracera macrophylla.&lt;/em&gt;&lt;strong&gt; Methods: &lt;/strong&gt;DPPH and FRAP were used to determine antioxidants, and the Folin–Ciocalteu method was used for total phenolic content, total flavonoid content with AlCl3 and toxicity with MTT assay against RAW 264.7 cells. &lt;strong&gt;Results:&lt;/strong&gt; Methanol extract has antioxidant activity with IC50 = 81.582 μg/mL (DPPH) and 11840 mol/g (FRAP), total phenolic content of 353.781 mg GAE/g dry weight, and flavonoid content of 279.2 mg QE/g dry weight. The ethyl acetate and n-hexane extracts had weaker antioxidant activity than the methanol extracts. The IC50 toxicity assay methanol extract and ethyl acetate extract respectively showed 288.792 μg/mL and 541.472 μg/mL.&lt;strong&gt; Conclusion&lt;/strong&gt;: The methanol extract of &lt;em&gt;Tetracera macrophylla&lt;/em&gt; showed the highest yield, total phenolic content and total flavonoid content and had the highest antioxidant activity. Methanol extract has low toxicity to RAW 264.7 cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">642-648</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vera Ladeska&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3,4&lt;/sup&gt;, Kusmardi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, University of Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof.Dr. Hamka,13460, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian National Research and Innovation Institute, Serpong, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy Phytochemistry, Faculty of Pharmacy University of Pancasila, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Miloud Chakit</style></author><author><style face="normal" font="default" size="100%">Rezklah Boussekkour</style></author><author><style face="normal" font="default" size="100%">Aboubaker El Hessni</style></author><author><style face="normal" font="default" size="100%">Youssef Bahbiti</style></author><author><style face="normal" font="default" size="100%">Redouan Nakache</style></author><author><style face="normal" font="default" size="100%">Hicham El Mustaphi</style></author><author><style face="normal" font="default" size="100%">Abdelhalim Mesfioui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiurolithiatic Activity of Aqueous Extract of Ziziphus lotus on Ethylene Glycol-Induced Lithiasis in Rats </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethylene glycol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Urinary parameter</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ziziphus lotus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">596-602</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In Morocco, &lt;em&gt;Ziziphus lotus&lt;/em&gt; is commonly used as an urolithiatic agent in the traditional medicine. To confirm this effect, an aqueous extract of &lt;em&gt;Ziziphus lotus&lt;/em&gt; (AEZL) has been studied in ethylene glycolinduced urolithiasis model of rats. 30 male rats were randomly divided into five groups of six animals each. Group I served as a vehicle control and received distilled water (0.5 ml/100 g p.o.). All remaining groups received calculi inducing treatment for 28 days, comprised of 0.75% v/v ethylene glycol with 1% w/v ammonium chloride in drinking water ad libitum for 3 days followed by only 0.75% v/v ethylene glycol for 25 days. Group II served as lithiatic control and received distilled water (0.5 ml/100 g p.o.). Group III served as curative treatment group and received AEZL at doses of 150 mg/kg from 14&lt;sup&gt;th&lt;/sup&gt; day to 28&lt;sup&gt;th&lt;/sup&gt; day. Group VI served as preventive treatment group and received AEZL at doses of 150 mg/kg from 1st day to 28th day. Group V served as therapeutic and received a drug “Cystone” at dose of 750 mg/kg from 14&lt;sup&gt;th&lt;/sup&gt; day to 28&lt;sup&gt;th &lt;/sup&gt;day. The extract treatment decreased the levels of oxalate and calcium in urine. Crystalluria analysis showed that untreated rats excreted large CaOx monohydrate and few dihydrate crystals while treated animals excreted mostly small CaOx dihydrate crystals. Significant similarity was observed between preventive and therapeutic anti-urolithiatic effect of AEZL and anti-urolithiatic effect of cystone (P&amp;lt;0.001). These results demonstrated that AEZL have an anti-urolithiatic effect with preventive and therapeutic treatments in this experimental condition.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">596</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Miloud Chakit*, Rezklah Boussekkour, Aboubaker El Hessni, Youssef Bahbiti, Redouan Nakache, Hicham El Mustaphi, Abdelhalim Mesfioui&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author><author><style face="normal" font="default" size="100%">Ratnawati Ratnawati</style></author><author><style face="normal" font="default" size="100%">Atina Hussaana</style></author><author><style face="normal" font="default" size="100%">Tjahja Muhandri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Powdered Active Compounds Made from Tender Coconut Water Fortified with Vitamin E, Processed by Spray Drying and Freeze Drying</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Freeze drying.</style></keyword><keyword><style  face="normal" font="default" size="100%">Spray drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">682-686</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Tender coconut water contains antioxidants vitamin C, amino acids, L-arginine, polyphenols, selenium, and minerals that prevent oxidative stress, anemia, and inflammation. It also lowers lipid profiles, increases enzyme antioxidant status, and controls lipid peroxidation. Previous investigations have shown that tender coconut water provides health benefits but is difficult to store. This is due to its short shelf life, which can be extended by drying to obtain a dry or powdered form. A special drying method to acquire dry materials and maintain the characteristics of the raw materials is spray or freeze drying. Objective: This study aims to develop tender coconut water into a powder fortified with vitamin E and to differentiate the active compound content of the powder processed by spray and freeze drying.&lt;strong&gt; Method:&lt;/strong&gt; This study used a randomized block design and the sample used was green tender coconut water (Viridis variety) aged about 5-7 months from the Bogor area. The procedures include the purchase of tender coconut water, followed by spray and freeze drying, while the content of active compounds that are beneficial to health was also analyzed. Drying was carried out at the Seafast Center Laboratory of Research and Community Service Institute, Bogor Agricultural Institute (IPB), while the active compound content was analyzed at the Integrated Research and Testing Laboratory, Gadjah Mada University (UGM), Yogyakarta. &lt;strong&gt;Result: &lt;/strong&gt;The active compounds analyzed from powder made from tender coconut water fortified with vitamin E were vitamin C, phenol, L-Arginine, L-Histidine, L-Lycine, L-Phenylalanine, L-Isoleucine, L-Leucine, L-Valine, and minerals consisting of Cu (Copper), Fe (Iron), Mg (Magnesium), Zn (Zinc), Na (Sodium), K (Potassium), and P (Phosphor). &lt;strong&gt;Conclusion: &lt;/strong&gt;There are differences in the content of active compounds in tender coconut water powder fortified with vitamin E between freeze and spray-drying methods.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Siti Thomas Zulaikhah&lt;sup&gt;1,*&lt;/sup&gt;, Ratnawati Ratnawati&lt;sup&gt;1&lt;/sup&gt;, Atina Hussaana&lt;sup&gt;2&lt;/sup&gt;, Tjahya Muhandri&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Sultan Agung Islamic University Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Food Science and Technology, Faculty of Agricultural Technology-Bogor Agricultural Institute and Seafast Center of Research and Community Service Institute- Bogor Agricultural Institute, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ichwan Baihaki</style></author><author><style face="normal" font="default" size="100%">Beti Ernawati Dewi</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Nunuk Hariani Soekamto</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Kuswati</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Kawther Ameen Muhammed Saeed Aledresi</style></author><author><style face="normal" font="default" size="100%">Nur Farhana Mohd Yusof</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Pavel Burkov</style></author><author><style face="normal" font="default" size="100%">Marina Derkho</style></author><author><style face="normal" font="default" size="100%">Pavel Scherbakov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Asmi Citra Malina AR Tasakka</style></author><author><style face="normal" font="default" size="100%">Tengku Siti Hajar Haryuna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dengue virus</style></keyword><keyword><style  face="normal" font="default" size="100%">NS1 antigen</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombocytopenia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">813-816</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p &amp;lt;0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">813</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ichwan Baihaki&lt;sup&gt;1&lt;/sup&gt;, Beti Ernawati Dewi&lt;sup&gt;2,3&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;4,5&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;7&lt;/sup&gt;, Nunuk Hariani Soekamto&lt;sup&gt;8&lt;/sup&gt;, ANM Ansori&lt;sup&gt;9&lt;/sup&gt;, Kuswati&lt;sup&gt;10&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;11&lt;/sup&gt;, Kawther Ameen Muhammed Saeed Aledresi&lt;sup&gt;12&lt;/sup&gt;, Nur Farhana Mohd Yusof&lt;sup&gt;13&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;14&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;15&lt;/sup&gt;,&lt;sup&gt;16,17&lt;/sup&gt;, Pavel Burkov&lt;sup&gt;18&lt;/sup&gt;, Marina Derkho&lt;sup&gt;18&lt;/sup&gt;, Pavel Scherbakov&lt;sup&gt;18&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;19,20,*&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;21&lt;/sup&gt;, Asmi Citra Malina AR Tasakka&lt;sup&gt;22&lt;/sup&gt;, Tengku Siti Hajar Haryuna&lt;sup&gt;23&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Indonesia-RSUPN Cipto Mangunkusumo, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Biology Education Study Program, Faculty of Teacher Training and Education, Jember University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Biochemistry Department, Hawler Medical University, Erbil, Arbil Governorate, Iraqi Kurdistan, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;20&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;21&lt;/sup&gt;Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;22&lt;/sup&gt;Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;23&lt;/sup&gt;Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">B Halim</style></author><author><style face="normal" font="default" size="100%">RA Syahputra</style></author><author><style face="normal" font="default" size="100%">I Adenin</style></author><author><style face="normal" font="default" size="100%">HP Lubis</style></author><author><style face="normal" font="default" size="100%">F Mendrofa</style></author><author><style face="normal" font="default" size="100%">S Lie</style></author><author><style face="normal" font="default" size="100%">SE Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Phytochemical Constituent, Antioxidant Activity, Total Phenol and Total Flavonoid of Extract Ethanol Phyllanthus emblica Fruit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">63-67</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Phyllanthus emblica &lt;/em&gt;(PE) is a plant that grows widely in Indonesia, particularly on Sumatra island. In India, it is known as Indian gooseberry and is frequently used in ayurvedic medicine. PE fruit is well-known for its high antioxidant activity and a variety of pharmacological properties. The purpose of this study was to ascertain the phytochemical composition, antioxidant activity, total phenol, and total flavonoid concentrations. &lt;strong&gt;Methods:&lt;/strong&gt; The fruits were harvested in the Indonesian town of Padang Sidimpuan. Up to 700 g of dry PE fruit powder was dissolved in 96 percent ethanol and macerated for seven days, with periodic steering daily. The solution was then filtered using Whatman paper no 1, and the filtered result was evaporated under reduced pressure using a rotary evaporator until a crude extract/ethanol extract of PE (EEPE) was obtained, and the phytochemical constituents, antioxidant activity, total phenol, and flavonoid were analysed. &lt;strong&gt;Results&lt;/strong&gt;: The result shows that EEPE contains some flavonoids such as quercetine, betaine, Trigonelline, Myricitrin, Myricetin, Leucine, and Kaempferol. EEPE as an antioxidant of 7.626 ± 0.41 μg/dL. It shows that the antioxidant activity of the ethanol extract of &lt;em&gt;Phyllanthus emblica&lt;/em&gt; is strong ethanol extract of &lt;em&gt;Phyllanthus emblica &lt;/em&gt;contains Total Flavonoid was 5.816 ± 2.81(mg QE/g extract) and total phenol was 274.590 ± 13.61(mg GAE/g extract). &lt;strong&gt;Conclusions&lt;/strong&gt;: In summary, extract ethanol of Pyllanthus emblica contains flavonoid and have antioxidant activity and high total phenol and flavonoid levels.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Antioxidant, Total flavonoid, Total phenol, Phyllanthus emblica..&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;B Halim&lt;sup&gt;1,3&lt;/sup&gt;, RA Syahputra&lt;sup&gt;2,*&lt;/sup&gt;, I Adenin&lt;sup&gt;3&lt;/sup&gt;, HP Lubis&lt;sup&gt;3&lt;/sup&gt;, F Mendrofa&lt;sup&gt;4&lt;/sup&gt;, S Lie&lt;sup&gt;5&lt;/sup&gt;, SE Nugraha&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Prima Indonesia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Klinik Riyena Orthomedik, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Akademi Keperawatan Colombia Asia, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Emranul Kabir</style></author><author><style face="normal" font="default" size="100%">M. R. O. Khan Noyon</style></author><author><style face="normal" font="default" size="100%">Md. Amjad Hossain</style></author><author><style face="normal" font="default" size="100%">Pranta Acharjee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">DFT and Pharmacokinetic Study of Some Heterocyclic Aspirin Derivatives as The Cyclooxygenase Inhibitors: An In-Silico Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ADMET.</style></keyword><keyword><style  face="normal" font="default" size="100%">Aspirin</style></keyword><keyword><style  face="normal" font="default" size="100%">DFT</style></keyword><keyword><style  face="normal" font="default" size="100%">Heterocyclic compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1005-1021</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ibuprofen and aspirin are frequently used to relieve inflammation, pain, and fever. These are the two most significant non-steroidal and anti-inflammatory drugs (NSAIDs). They prevent the development of prostaglandin by blockampounds have been assessed by ibuprofen as well as quantum mechanical computations. Density functional theory (DFT) with the B3LYP/6-31G+ basis function has been used to elucidate the thermo-chemical, molecular orbital, and optimum geometrical aspects in the gas phase. Using molecular docking and non-bonding interactions, the binding affinities and behaviors of some heterocyclic aspirin analogs have been studied on human cyclooxygenase (COX-1 as well as COX-2) proteins (6Y3C and 5F19). The chemical stability of all structures is supported by geometry and thermo-chemical findings. In contrast to aspirin and ibuprofen, almost all tested analogs exhibited a substantial binding score to the receptor protein (5F19). The ADMET prediction revealed the enhanced pharmacokinetic properties of some derivatives with less acute oral toxicity. Overall, eight heterocyclic aspirin analogues 2-9 were shown to be more effective in inhibiting Cyclooxygenase-2 (5F19) than Cyclooxygenase-1 (6Y3C), indicating that they may be effective as COX-2-related inflammation therapeutic candidates.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1005</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Emranul Kabir&lt;sup&gt;1, 2,*&lt;/sup&gt;, M. R. O. Khan Noyon&lt;sup&gt;1&lt;/sup&gt;, Md. Amjad Hossain&lt;sup&gt;1&lt;/sup&gt;, Pranta Acharjee&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, Department of Chemistry, University of Chittagong, Chittagong, 4331, BANGLADESH.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Electrical and Electronic Engineering, International Islamic University Chittagong, Chittagong, 4318, BANGLADESH.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Silvia W Lestari</style></author><author><style face="normal" font="default" size="100%">Khairunnisa F Ilato</style></author><author><style face="normal" font="default" size="100%">M. Iqbal A Pratama</style></author><author><style face="normal" font="default" size="100%">Husna Qonitah</style></author><author><style face="normal" font="default" size="100%">Gito Wasian</style></author><author><style face="normal" font="default" size="100%">Amandanu Bramantya</style></author><author><style face="normal" font="default" size="100%">Firda A Husna</style></author><author><style face="normal" font="default" size="100%">Ria Margiana</style></author><author><style face="normal" font="default" size="100%">Gita Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Does Soybean (Glycine max) Supplementation Increase Oocyte Viability, Decrease Oocyte Apoptosis and Improve Embryo Development Quality? An Experimental Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">133-140</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the important factors in Assisted Reproductive Technology (ART) is embryo quality that depends on oocyte quality. Maternal nutrition in form of soybean supplementation is thought to have benefits in oocyte quality. To determine the effect soybean supplementation to the embryo quality from oocyte side. &lt;strong&gt;Methods: &lt;/strong&gt;This experimental study involved female mice from Swiss strain aged 6 weeks that were divided into two groups, group with soybean (soybean group/SG) and group without soybeans (pellet group/PG). Follicles were collected and denuded to get oocytes. The oocytes were stained with MitoTracker for assessing the mitochondrial membrane potential and TUNEL for assessing the apoptotic level. Colour intensity was assessed using a confocal microscope and determined using ImageJ software. Sperms were extracted surgically from the epididymis-vas deferens and performed preparation prior to intra cytoplasmic sperm injection (ICSI) procedure. Then, the embryos were cultured and observed for the quality. &lt;strong&gt;Result&lt;/strong&gt;: In TUNEL test, the average colour intensity of the SG was lower compared to the PG, significantly (p=0.03). While in the Mito Tracker test, the average colour intensity for the SG was higher compared to PG, not significantly (p=1.08). In addition, the embryo development on Day-1 and Day-3 showed more good embryo quality of SG compared to PG, significantly (p=0.03). &lt;strong&gt;Conclusion&lt;/strong&gt;: Soybean supplementation improved embryo quality at the cleavage stage by decreasing apoptosis of the oocytes rather than increasing the viability the oocytes.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Oocyte, Soybean, Apoptosis, Embryo development, Embryo quality.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">133</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Silvia W Lestari&lt;sup&gt;1,*&lt;/sup&gt;, Khairunnisa F Ilato&lt;sup&gt;2&lt;/sup&gt;, M. Iqbal A Pratama&lt;sup&gt;2&lt;/sup&gt;, Husna Qonitah&lt;sup&gt;3&lt;/sup&gt;, Gito Wasian&lt;sup&gt;1&lt;/sup&gt;, Amandanu Bramantya&lt;sup&gt;2&lt;/sup&gt;, Firda A Husna&lt;sup&gt;4&lt;/sup&gt;, Ria Margiana&lt;sup&gt;5&lt;/sup&gt;, Gita Pratama&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Undergraduate Study of Medicine of Faculty Medicine, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Undergraduate Study of Biology of Faculty Mathematics and Natural Science, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Master’s programme in biomedical medicine of Faculty Medicine, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Obstetry &amp;amp; Gynecology, Faculty of Medicine, Universitas Indonesia – Ciptomangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Antioxidant activity, Total Phenols and Total Flavonoids on Arginase Inhibitory Activity on Plants of Genus Sterculia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Arginase</style></keyword><keyword><style  face="normal" font="default" size="100%">Enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">322-328</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The genus of Sterculia has the main compound of phenol and flavonoids. The secondary metabolites which have an arginase inhibitory activities were phenol and flavonoids. The aim of this study was to investigate the arginase inhibitory activity from genus Sterculia. The Plant of&lt;em&gt; Sterculia: Sterculia rubiginosa Zoll.&lt;/em&gt; ex Miq., &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb., &lt;em&gt;Sterculia parkinsonii&lt;/em&gt; F. Muell, &lt;em&gt;Sterculia macrophylla &lt;/em&gt;Vent,&lt;em&gt; Sterculia Stipulata Korth. &lt;/em&gt;The simplisia were leaves and woods. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The simplisia were extracted with n-hexane, ethyl acetate and methanol. The ethyl acetate and methanol extract determined the arginase inhibition activity. The active extracts as an arginase inhibitory, determined the total flavonoids, total phenols and antioxidant activity, and the chemical content. &lt;em&gt;Sterculia comosa&lt;/em&gt; (Wall) Roxb., Sterculia macrophylla Vent, &lt;em&gt;Sterculia Stipulata Korth.&lt;/em&gt;, have arginase inhibitory activity. &lt;strong&gt;Results: &lt;/strong&gt;The ethyl acetate extracts of Sterculia Stipulata leaves is an active extract. The methanol extract which have an arginase inhibitor activity were Sterculia comosa (Wall) Roxb. wood and leaves, Sterculia macrophylla Vent., wood and leaves, &lt;em&gt;Sterculia stipulata&lt;/em&gt; &lt;em&gt;Korth., &lt;/em&gt;wood, and leaves. The methanol extract of &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb. Woods has the highest content of total phenols, antioxidant activity, and arginase inhibitory activity. The methanol extract of &lt;em&gt;Sterculia macrophylla &lt;/em&gt;Vent. has the highest content of total flavonoids, but this extract as an arginase inhibitory activity more lower than &lt;em&gt;Sterculia comosa.&lt;/em&gt; The active extract as an arginase activity was methanol extract of &lt;em&gt;Sterculia comosa &lt;/em&gt;(Wall) Roxb. &lt;strong&gt;Conclusion:&lt;/strong&gt; The total phenols were more contributed for the response of the arginase inhibitory activity much more than antioxidant activity and total flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">322</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,*&lt;/sup&gt;, Berna Elya&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3,4&lt;/sup&gt;, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt;, Rani Sauriasari&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof. Dr. Hamka University, 1340 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Indonesia University, Depok 16424, West Java, INDONESIA. 4Research Centre for Chemistry - National Research and Innovation Agency (BRIN), INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sampurna</style></author><author><style face="normal" font="default" size="100%">Andin Putri Aulia</style></author><author><style face="normal" font="default" size="100%">Eka Puji Liashari</style></author><author><style face="normal" font="default" size="100%">Happy Hapsari</style></author><author><style face="normal" font="default" size="100%">Syafrie Sahrul Gibran</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Bajakah Tea Extract (Spatholobus littoralis Hassk) on High Density Lipoprotein, Triglyceride and Total Cholesterol Levels in Male Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HDL levels</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Pirated tea extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Total cholesterol.</style></keyword><keyword><style  face="normal" font="default" size="100%">Triglycerides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">687-691</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Hyperlipidemia is the high concentrations of low-density lipoprotein, cholesterol, and triglycerides in the blood. Furthermore, hyperlipidemia has a risk factor for cardiovascular complications through atherosclerosis that triggers coronary heart disease (CHD). &lt;em&gt;Spatholobus littoralis&lt;/em&gt; Hassk known as Bajakah tea is a plant with high antioxidant content and acts as an HMG-CoA reductase inhibitor to suppress lipid metabolism disorders, increase HDL levels, and reduce triglycerides and total cholesterol. Experimental and posttest control group design methods were used to obtain 24 male Wistar rats. Furthermore, the experimental animals were randomly divided into 4 groups, namely K1 (normal rats), K2 (hyperlipidemia rats), K3 (hyperlipidemic rats + pirated tea extract dose 9 mg/200gramBW/day), and K4 (hyperlipidemic rats + simvastatin dose 0.18 mg/200 gBW/day). The study was conducted at the Center for Food and Nutrition Studies Laboratory, Gajah Mada University, Yogyakarta. Data levels of HDL, triglycerides, and total cholesterol were analyzed using the One Way Anova test and LSD post hoc to determine between groups. The results showed that an increase in triglyceride and total cholesterol and a decrease in HDL levels in the K2 group compared to the K1. Triglyceride and total cholesterol decreased in groups K3 and K4 compared to K2, and HDL levels increased in groups K3 and K4 compared to K2. Meanwhile, the results of the analysis obtained p value &amp;lt;0.05. This study concluded that the administration of Bajakah tea extract at a dose of 9 mg/200gram BW/day for 14 days increase HDL, reduce triglyceride and total cholesterol levels (p&amp;lt;0,05).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sampurna&lt;sup&gt;1,*&lt;/sup&gt;, Andin Putri Aulia&lt;sup&gt;1&lt;/sup&gt;, Eka Puji Liashari&lt;sup&gt;2&lt;/sup&gt;, Happy Hapsari&lt;sup&gt;2&lt;/sup&gt;, Syafrie Sahrul Gibran&lt;sup&gt;2&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student of the Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Sultan Agung Islamic University (UNISSULA), INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Paulus Anthony Halim</style></author><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Omega-3 Rich Fish Oil on the Kidney Changes in Mice Induced by Azoxymethane and Dextran Sodium Sulfate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azoxymethane</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextran sodium sulfate</style></keyword><keyword><style  face="normal" font="default" size="100%">Fish oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega-3</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">259-266</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: The study aimed to investigate the effect of omega-3 rich fish oil to kidney of mice induced by Azoxymethane (AOM) and DSS using histopathology parameters. &lt;strong&gt;Method:&lt;/strong&gt; The experimental mice were induced using 10 mg/kg AOM and 2% DSS for 2 weeks randomly allocated randomly into four groups as follows;&lt;strong&gt; Control Group:&lt;/strong&gt; mice that not received fish oil, Low Dose Group: mice that received 1.5 mg/day fish oil, Medium Dose Group: mice that received 3 mg/day fish oil, and High Dose Group: mice that received 6 mg/day fish oil. The omega-3 rich fish oil was given for 12 weeks. &lt;strong&gt;Result:&lt;/strong&gt; The administration of high dose omega-3 rich fish oil was able to reduced necrosis and inflammation foci compared to the control group (p&amp;lt;0.05). Furthermore, the administration of low, medium, and high dose omega-3 rich fish oil was able to significantly reduced vascular edema and cell degeneration foci (p&amp;lt;0.05). The administration of medium and high dose of omega-3 rich fish oil were able to reduce the amount of fibrosis foci compared to the control group (p&amp;lt;0.05) compared to the control group. &lt;strong&gt;Conclusion: &lt;/strong&gt;The result suggested anti-nephrotoxic effect of omega-3 rich fish oil in mice induced by azoxymethane and DSS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">02</style></accession-num><section><style face="normal" font="default" size="100%">259</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Paulus Anthony Halim&lt;sup&gt;3&lt;/sup&gt;, Wachid Putranto&lt;sup&gt;4,*&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta 10340, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, 10430, Jakarta, Indonesia, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dody Taruna</style></author><author><style face="normal" font="default" size="100%">Bambang Purwanto</style></author><author><style face="normal" font="default" size="100%">Harianto Notopuro</style></author><author><style face="normal" font="default" size="100%">Widjiati</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Lilik Herawati</style></author><author><style face="normal" font="default" size="100%">Reny I'tishom</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of High Intensity Swimming on Heat Shock Protein 70, Superoxide Dismutase and Malondialdehyde of Rattus norvegicus Male Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSP-70</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA.</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword><keyword><style  face="normal" font="default" size="100%">Strenuous physical activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">524-530</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;This study aims to analyze relationship between physical activity with high intensity swimming by proving the difference in the mean levels of HSP-70, SOD levels and MDA levels in male white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who perform vigorous-intensity physical activity compared to male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;strong&gt; Method&lt;/strong&gt;: This research is a laboratory experimental research. This research is a True Experimental Research type that uses a Post Test Only Control Group Design research design. The experimental unit consisted of 28 white rats (&lt;em&gt;Rattus norvegicus&lt;/em&gt;). The study was started by dividing the rats into 2 groups. Group 0 who did not receive heavy physical activity treatment and group 1 who received heavy intensity physical activity treatment 3 times a week for 4 weeks. &lt;strong&gt;Results: &lt;/strong&gt;The results of the Shapiro-Wilk test showed that the HSP-70 data were normally distributed (p&amp;lt;0.05). SOD and MDA data for all groups were normally distributed (p&amp;gt;0.05). The results of the Kruskal Wallis test showed that there was a significant difference in HSP-70 between groups (p &amp;gt; 0.05), the results of the Mann Whitney test showed that the HSP-70 of the K0 group was significantly different from the K1 group. The results of the analysis of variance with Brown-Forsythe showed that there was a significant difference in SOD between groups (p &amp;lt; 0.05). The results of the Games Howell test showed that the SOD of group K0 was significantly different from that of group K1. The results of the analysis of variance showed that there was a significant difference in MDA between groups (p &amp;lt; 0.05). The results of the LSD test showed that the MDA of the K0 group was significantly different from the K1 group. &lt;strong&gt;Conclusion&lt;/strong&gt;: There is a difference in the mean levels of HSP-70 in white male rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) whoperform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity. There is a difference in the mean SOD levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) which perform strenuous physical activity, lower than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not do strenuous physical activity. There is a difference in the mean MDA levels in male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) after doing strenuous physical activity, higher than male white rat (&lt;em&gt;Rattus norvegicus&lt;/em&gt;) who do not engage in strenuous physical activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">524</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dody Taruna&lt;sup&gt;1&lt;/sup&gt;, Bambang Purwanto&lt;sup&gt;2&lt;/sup&gt;, Harianto Notopuro&lt;sup&gt;2&lt;/sup&gt;, Widjiati&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;, Lilik Herawati&lt;sup&gt;2&lt;/sup&gt;, Reny I'tishom&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Affiliated Doctoral Program of Medical Science, Medical Faculty, Airlangga University, Surabaya, Indonesia. Medical Faculty, Hang Tuah University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Doctoral Program, Medical Faculty, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Audylia Hartono</style></author><author><style face="normal" font="default" size="100%">Mahrus A. Rahman</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Pomegranate Extract Supplementation (Punica granatum L.) on Clinical Manifestations of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Heart disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Pomegranate</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Sildenafil.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1061-1066</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) mechanism includes vasoconstriction and vascular remodeling. In Indonesia, sildenafil as a vasodilator is the only standard treatment for PAH. Research on pomegranate extract showed its potential as an anti-inflammatory and anti-proliferative agent that could work synergically with sildenafil in reducing pulmonary arterial pressure (PAP) &lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effect of pomegranate supplementation in the clinical manifestation of PAH in children with acyanotic CHD. Methods: This study was a randomized controlled clinical trial that compared the clinical manifestation of PAH in children with acyanotic CHD who received standard therapy for PAH and pomegranate extract supplementation with the placebo group. Observations were carried out over three months, and pre-and post-test evaluations were conducted to assess changes in PAP, functional classification of PAH, body weight, systolic blood pressure, heart rate, respiratory rate, and oxygen saturation in both groups. Statistical analysis was undertaken using the Wilcoxon, Mann-Whitney, and Spearman correlation tests.&lt;strong&gt; Results:&lt;/strong&gt; There was no significant difference in PAP reduction between the pomegranate and placebo groups (&lt;em&gt;p &lt;/em&gt;= .44) and no significant difference in the functional classification of PAH in the placebo and pomegranate groups (&lt;em&gt;p&lt;/em&gt; = .55). There was a considerable reduction in the respiratory rate in the pomegranate group (&lt;em&gt;p&lt;/em&gt; = .017). Respiratory rate was positively correlated with the functional classification of PAH &lt;em&gt;(p&lt;/em&gt; = .011).&lt;strong&gt; Conclusion:&lt;/strong&gt; There was a significant reduction in the respiratory rate in the pomegranate group that correlated with the functional classification of PAH.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1061</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Audylia Hartono&lt;sup&gt;1&lt;/sup&gt;, Mahrus A. Rahman&lt;sup&gt;1,*&lt;/sup&gt;, Budi Utomo&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health, Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iwan Sahrial Hamid</style></author><author><style face="normal" font="default" size="100%">Juni Ekowati</style></author><author><style face="normal" font="default" size="100%">Rondius Solfaine</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Efficacy of Probiotic on Duodenal TNF-α Expression and the Histological Findings in the Liver and Lung in Animal Model Canine Coronavirus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Canine coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung</style></keyword><keyword><style  face="normal" font="default" size="100%">Probiotic</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">591-597</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Currently, Canine coronavirus (CCoV) is an enteric pathogen of the Alphacoronavirus-1 species that causes mild to severe diarrhea in puppies. The pathogenesis of this infection will cause severe lymphopenia and lead to death in puppies. This study aimed to determine the administration of probiotics on TNF-α expression, histological findings of the liver and lung in mice infected with CCoV. A total of 28 mice were randomly assigned into seven treatment groups, i.e. (C-) placebo; (C+) active CCoV vaccine induction; (T1) CCov + Isopronosin; (T2) CCoV + Lactobacillus acidophilus probiotic; (T3) CCoV + Lactobacillus Acidophylus and Bifidobacterium probiotics; (T4) CCoV + colustrum fermentation probiotic; (T5) CCoV + ginger, turmeric and ginger probiotics. Thereafter, the expression of TNF-α in the duodenum was stained using immunohistochemistry, liver and lung were stained using hematoxylin eosin. The data were analyzed using the ANOVA test followed by the Tukey test with a significance level (p&amp;lt;0.05). TNF-α expression on T4 and T5 decreased significantly (p&amp;lt;0.05) compared to C+, T1, T2 and T3. Histologic findings of the liver in the C- and T4 groups showed normal features in the central vein. On the other hand, glycogen accumulation was found in hepatocyte cells, hemorrhage with sinusoid dilation, lymphocyte infiltration in centro lobular area in group C+. Lung histology showed normal features of sinusoids and alveolar septa in groups C- and T4. Meanwhile, intra-alveolar hemorrhage was found with neutrophil cell infiltration and fibrin plasma accumulation in group C+. In conclusion, colostrum fermentation probiotics can reduce TNF-α expression in the duodenum and improve the liver and lung physiology in mice infected with CCoV.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">16</style></accession-num><section><style face="normal" font="default" size="100%">591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Iwan Sahrial Hamid&lt;sup&gt;1,*&lt;/sup&gt;, Juni Ekowati&lt;sup&gt;2&lt;/sup&gt;, Rondius Solfaine&lt;sup&gt;3&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pathology, Faculty of Veterinary Medicine, Universitas Wijaya Kusuma Surabaya, Surabaya, 60225, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, 13001, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Candra Irawan</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Ethanolic Extract of Rhinachantus nasutus (L.) Kurz Flower has Antioxidant, Anti-Gout, and Antibacterial Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">RnLK</style></keyword><keyword><style  face="normal" font="default" size="100%">TBHBA</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">867-872</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The goal of this research was to explore the potential of &lt;em&gt;Rhinachantus nasutus&lt;/em&gt; (L.) Kurz (RnLK) flower extract as an antioxidant utilizing the ferric reducing antioxidant power (FRAP) method; the possibility that it might be used as a treatment for gout by employing the 2,4,6-tribromo-3-hydroxybenzoic acid (TBHBA) technique, as well as the possibility that it could be used as an antibacterial agent against&lt;em&gt; E. coli &lt;/em&gt;and B. subtilis. Results: The IC&lt;sub&gt;50 &lt;/sub&gt;value for the extract's ability to serve as an antioxidant is 8.62±0.006 mg/L, indicating that it is quite effective. In addition, the extract of ethanol possesses highly potent anti-gout properties, being capable of bringing about a 81.95±0.1% reduction in uric acid levels. In spite of this, the antibacterial properties of &lt;em&gt;E. coli &lt;/em&gt;as well as &lt;em&gt;B. subtilis&lt;/em&gt; bacteria were not particularly robust. Conclusion: The RnLK flower has the potential to produce alternative chemicals with the ability to reduce blood uric acid levels, but according to the results of the test, the antibacterial activity has little impact on &lt;em&gt;E. coli&lt;/em&gt; and B. subtilis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">867</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Candra Irawan&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Food Nanotechnology, Politeknik AKA Bogor, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Miloud Chakit</style></author><author><style face="normal" font="default" size="100%">Aboubaker El Hessni</style></author><author><style face="normal" font="default" size="100%">Abdelhalim Mesfioui</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical Study of Plants Used for the Treatment of Urolithiasis in Morocco </style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Morocco.</style></keyword><keyword><style  face="normal" font="default" size="100%">Questionnaire</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Urolithiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">542-547</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Urolithiasis (UL) is a frequent pathology which affects between 5 and 20% of the population according to the countries and areas. The aim of this study was to determine the medicinal plants used traditionally by patients with UL in the Kenitra and Sidi Kacem cities (Morocco). From January 2012 to February 2015, 50 herbalists and 166 patients with urolithiasis who live in the area under study were interviewed by using structured questionnaire. The following data were recorded: name of the patients or herbalists with their age, sex name of the plant (s) (vernacular name), parts used mode of preparation and administration. A total of 42 plant species belonging to 24 families, mostly from the Apiaceae (16.66%) &lt;em&gt;Lamiaceae&lt;/em&gt; (11.9%) were used to treat the UL in the area. All the plants were prepared by decoction which are taken orally for a period of one week. &lt;em&gt;Herniaria hirsuta &lt;/em&gt;(Hh) and &lt;em&gt;Ziziphus lotus &lt;/em&gt;(Zl) were repeatedly mentioned by the patients and herbalists as most used for the management of UL in this area. It’s concluded that the traditional remedies are the first line to treat the UL in this area. Hh and Zl were the most commonly used plants in this treatment which a study of antiurolithiatic characteristics seem to be necessary to evaluate its use in therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">542</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Miloud Chakit*, Aboubaker El Hessni, Abdelhalim Mesfioui&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sri Agus Sudjarwo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Characterization of Meniran (Phyllanthus Niruri Linn) Extract Nanoparticle on Antibacterial Activity Against Salmonella Pullorum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword><keyword><style  face="normal" font="default" size="100%">Salmonella Pullorum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">369-373</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to examine the results of meniran extract (&lt;em&gt;Phyllanthus niruri Linn.&lt;/em&gt;) on antibacterial activity. &lt;em&gt;Salmonella Pullorum&lt;/em&gt; is capable of causing huge economic losses. The misuse of antimicrobials has resulted in the evolution of multidrug-resistant strains. Meniran has potential as an antibacterial because it contains many bioactive components such as alkaloids, flavonoids, tannins and saponins. Nanoparticles help in the bioavailability of plant extracts. The research was conducted by making a meniran extract nanoparticles formulation with ionic glass method using chitosan and TPP sodium with a dose difference of 5%, 10% and 20%. Each dose of meniran nanoparticles then were characterized by PSA, SEM and TEM. The result on PSA showed that size range from 192.67 nm to 385.16 nm and 5% meniran extract nanoparticles have the best homogeneity and stability. EE value showed that the increase in the dose was directly proportional to the increase in the EE value. The result on SEM showed that the overall production of nanoparticle samples, it looks like they are nano-sized. The result on TEM showed small sample morphology with a good distribution. After that, the antibacterial activity test was then carried out using the MIC and MBC tests. The results showed that 5% of meniran extract nanoparticles had the best antibacterial activity against Salmonella Pullorum.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">369</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Hidanah, Emy Koestanti Sabdoningrum*, Sri Agus Sudjarwo&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamad Al- Hamwi</style></author><author><style face="normal" font="default" size="100%">MahaAboul Ela</style></author><author><style face="normal" font="default" size="100%">Abdalla El-Lakany</style></author><author><style face="normal" font="default" size="100%">Youssef BAKKOUR</style></author><author><style face="normal" font="default" size="100%">Ziad Mahmoud</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">FTICR/MS Analysis of Micromeria Fruticosa and Teucrium Polium Growing in Lebanon</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">112-127</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Micomeria fruticosa&lt;/em&gt; and &lt;em&gt;Teucrium polium &lt;/em&gt;are&lt;em&gt; Lamiaceae &lt;/em&gt;plants found throughout the Mediterranean, including Lebanon. Aerial parts of both plants were taken from a rocky mountain in Lebanon's Bekaa region and alcoholic extraction and chromatographic separation were performed. Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) was used to examine crude extracts of both plants A and B, as well as their fractions. The mass spectra of both plants revealed great chemical complexity with a total of 6352 ions (peaks) for crude extract of plant A and 5147 ions (peaks) for extract B. The majority of chemicals found in both plants are condensed aromatics, particularly polyphenols which could explain the previously documented anticancer effects of both plants.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Micromeria, Teucrium chromatographic analysis, FTICR-MS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">112</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohamad Al- Hamwi&lt;sup&gt;1,*&lt;/sup&gt;, MahaAboul Ela&lt;sup&gt;1&lt;/sup&gt;, Abdalla El- Lakany&lt;sup&gt;1&lt;/sup&gt;, Youssef BAKKOUR&lt;sup&gt;2&lt;/sup&gt;, Ziad Mahmoud&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Beirut Arab University, LEBANON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lebanese University, LEBANON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zuhair Radhi Addai</style></author><author><style face="normal" font="default" size="100%">Meethaq Satter Abood</style></author><author><style face="normal" font="default" size="100%">Shrrog Hammed Hlail</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Profiling, Antioxidants and Antimicrobial Activity of Prickly Pear (Opuntiaficus-indica) Pulp Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Fraction</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Prickly pear pulp</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">262-267</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The objective of this study was to evaluate phytochemical screening, antioxidants and antimicrobial activity of prickly pear pulp extract. Phytochemical screening was performed on the methanolic extract of the sample followed by gas chromatography mass spectrometry (GC-MS).The antioxidant activity was determined by measuring total phenolic content (TPC), ferric reducing antioxidant power (FRAP) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The antibacterial activity was determined using paper disc method against two bacteria namely &lt;em&gt;Staphylococcus aureus and Escherichia coli. &lt;/em&gt;Total of 36 compounds belonging to phenolics, anhydrides, aldehydes, fatty acids and hydrocarbons were identified in the extracts. The highest content of total phenol and antioxidant activity (FRAP and DPPH) were found in methanol extract228.50 ± 3.67. mg GAE/100g DW, 118.63 ±3.86 mg TE/100g DW and 92.81% respectively. The maximum zone of inhibition observed was 14.45 ± 0.67 mm against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; at methanol extract. It was concluded that fractions solvent plays important roles on the bioactive compound of prickly pear pulp extract and it can be used to control infectious diseases and prevent oxidative damage.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">02</style></accession-num><section><style face="normal" font="default" size="100%">262</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zuhair Radhi Addai*, Meethaq Satter Abood, Shrrog Hammed Hlail&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology, Faculty of Education&amp;nbsp;for Pure Sciences, University of Thi-Qar, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wisnu Cahyo Prabowo</style></author><author><style face="normal" font="default" size="100%">Risna Agustina</style></author><author><style face="normal" font="default" size="100%">Yuspian Nur</style></author><author><style face="normal" font="default" size="100%">Ramila Hidayati</style></author><author><style face="normal" font="default" size="100%">Dewi Rahmawati</style></author><author><style face="normal" font="default" size="100%">M. Arifuddin</style></author><author><style face="normal" font="default" size="100%">Neneng Siti Silfi Ambarwati</style></author><author><style face="normal" font="default" size="100%">Reza Yuridian Purwoko</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Green and Optimum Extraction of Total Polyphenols Content from Mitragyna speciosa Korth. Havil Leaves using Microwave- Assisted Natural Deep Eutectic Solvent Extraction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">29-38</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The current study mainly aims to apply and optimize the microwave-assisted natural deep eutectic solvent extraction (MANDESE) method of total polyphenol content from &lt;em&gt;Mitragyna speciosa&lt;/em&gt; (Korth.) Havil leaves using response surface methodology (RSM) and its extraction mechanism using scanning electron microscopy (SEM) imaging. The extraction process was performed using the maceration and MANDESE method. Total polyphenols content was examined using Folin-Ciocalteu reagent and spectrophotometer UV-Vis. The extraction mechanism was performed using SEM imaging. The extraction condition as experimental design variable factors for optimization using RSM included NADES composition ratio, the liquid-solid ratio, extraction time, and microwave power. The results show that the MANDESE with some different combinations of NADES composition is more effective than a maceration. SEM imaging result shows that the levels of damage of cells and cell walls were more severe after extraction. The optimum extraction condition has obtained the NADES composition ratio of 3 g/g (choline chloride/sorbitol) and the liquid-solid ratio of 20 mL/g for 20 min extraction time with 60% Watts microwave power. The scale-up confirmation test was obtained the total polyphenols content of 526.12 μg GAE/g sample. This finding demonstrated the optimum condition of the MANDESE method and performed efficiently, rapidly, safely, and environmentally friendly.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Microwave-assisted natural deep eutectic solvent extraction, Mitragyna speciosa (Kort.) Havil, Response surface methodology, Total polyphenols content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">29</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wisnu Cahyo Prabowo&lt;sup&gt;1&lt;/sup&gt;, Risna Agustina&lt;sup&gt;2&lt;/sup&gt;, Yuspian Nur&lt;sup&gt;2&lt;/sup&gt;, Ramila Hidayati&lt;sup&gt;1&lt;/sup&gt;, Dewi Rahmawati&lt;sup&gt;1&lt;/sup&gt;, M. Arifuddin&lt;sup&gt;1&lt;/sup&gt;, Neneng Siti Silfi Ambarwati&lt;sup&gt;3&lt;/sup&gt;, Reza Yuridian Purwoko&lt;sup&gt;4&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;5&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmaceutical Research and Development of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, 13220 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Military Medicine, Universitas Pertahanan RI, Bogor, 16810 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hani Plumeriastuti</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Djoko Legowo</style></author><author><style face="normal" font="default" size="100%">Bilqisthi Ari Putra</style></author><author><style face="normal" font="default" size="100%">Gracia Angelina H</style></author><author><style face="normal" font="default" size="100%">Agung Budianto Achmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Histopathological Perspectives of Multiple Organs in a Red- Footed Tortoise (Chelonoidis carbonaria) with Suspected Metabolic Bone Disease: A Case Report</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hematoxylin-eosin</style></keyword><keyword><style  face="normal" font="default" size="100%">MBD</style></keyword><keyword><style  face="normal" font="default" size="100%">Septicemia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tortoise</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1075-1078</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Introduction: Exotic pet lovers' interest in keeping tortoises is increasing all over the world, including Indonesia. However, this trend cannot be separated from the potential emergence of various health problems in tortoises. One of the problems that often affects tortoises is metabolic bone disease. Metabolic bone disease (MBD) is a disorder related to the mechanisms of vitamin D and calcium metabolism, which generally occurs in reptiles, especially Chelonia and Lizards. Case Presentation: A 3-month-old redfooted tortoise, which was clinically suspected to have a MBD, was necropsied as an effort to support the provisional diagnosis through histopathological evaluation. The purpose of this examination was to analyze the impact of the disease on various organs microscopically in patients with suspected MBD. The results showed a decrease in the number of trabeculae and hematopoietic cells in the metatarsal bones; moderate myonecrotic changes and atrophy in the skeletal muscle; inflammation of the perineuron; acute tubular necrosis and mild edema of the renal cortex; congestion and an increase in the number of melanomacrophages in the liver; as well as epicarditis and myocarditis in the heart. Conclusion: Several forms of the histopathological changes seem to indicate a pathophysiological relationship between the suspected metabolic bone disease and the multiple organs examined.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">1075</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hani Plumeriastuti&lt;sup&gt;1,*&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;1&lt;/sup&gt;, Djoko Legowo&lt;sup&gt;1&lt;/sup&gt;, Bilqisthi Ari Putra&lt;sup&gt;1&lt;/sup&gt;, Gracia Angelina Hendarti&lt;sup&gt;2&lt;/sup&gt;, Agung Budianto Achmad&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Pathology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Anatomy, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effect of Carallia Brachiata Extract Through Regulation of Adipogenesis Pathways in 3T3-L1 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3T3-L1 adipocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Adipogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Carallia brachiata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">655-660</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pharmacological effects of &lt;em&gt;Carallia brachiata Merr&lt;/em&gt;. has been reported to show antioxidant effects against the development of diabetes. However, the mechanism underlying antiadipogenic activity have not been investigated. &lt;strong&gt;Objective:&lt;/strong&gt; Effect of&lt;em&gt; Carallia brachiata&lt;/em&gt; ethanolic extract was determined on inhibition of adipogenesis in 3T3-L1 adipocytes.&lt;strong&gt; Materials and Methods&lt;/strong&gt;: Adipose tissue development was performed in preadipocyte 3T3-L1 cells culture. &lt;em&gt;Carallia brachiata&lt;/em&gt; leaf (CL) and stem (CS) part were selected for measuring cytotoxicity, accumulation of lipids, and genes involved in adipogenic differentiation. &lt;strong&gt;Results:&lt;/strong&gt; During the adipogenic differentiation, CS down-regulated gene expression of adipogenic transcription factors (PPARγ, C/EBPα, aP2, FAS, LPL and SREBP1c). However, CL only suppressed SREBP1c and aP2 genes. The accumulation of lipids was suppressed by CS, but CL could not show this effect. &lt;strong&gt;Conclusion&lt;/strong&gt;: Our findings suggest that ethanol extract of &lt;em&gt;Carallia brachiata&lt;/em&gt; stem has a better anti-adipogenesis effect than the leaf part by suppressing adipogenesis-related gene expression. Moreover, inhibition of lipid storage could be decreased insulin resistance risk.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">655</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Medicine and Public Health, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dewita</style></author><author><style face="normal" font="default" size="100%">Desmelati</style></author><author><style face="normal" font="default" size="100%">Santhy W. Sidauruk</style></author><author><style face="normal" font="default" size="100%">Taufik Hidayat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Characterization of Snakehead Fish Meal Extract with Fresh, Boiled, and Steamed Treatments and Its Potential for Health Drinks and  Immunomodulators</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Food product</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunomodulator</style></keyword><keyword><style  face="normal" font="default" size="100%">Sds page.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">532-536</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Albumin is one of the proteins that currently have an important role for the organism's body. This study aims to determine the characteristics of albumin with several treatments which will later be applied to cendol drinks. The treatments for extraction and albumin flour were fresh, boiled, and steamed, which were tested for extract yield, amino acids, and molecular identification using SDS-Page. The results showed that the steam treatment of the extract produced the highest yield of 0.42g/dL. The highest amino acid was in albumin flour with boiled treatment, namely each essential amino acid, namely leucine and non-essential amino acid, namely leucine. Identification of albumin molecular weight showed that albumin was found only in fresh and flour conditions when fresh. Other results indicate the possibility of processing factors affecting the presence of albumin which is easily soluble in water. albumin isolation from snakehead fish can potentially be developed into immunomodulatory health products&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">532</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dewita&lt;sup&gt;1,*&lt;/sup&gt;, Desmelati&lt;sup&gt;1&lt;/sup&gt;, Santhy W. Sidauruk&lt;sup&gt;1&lt;/sup&gt;, Taufik Hidayat&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fishery Products Technology, University of Riau, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Agroindustry, National Innovation Research Agency, Laptiab Building 614 Puspiptek Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wisda Medika Valentidenta</style></author><author><style face="normal" font="default" size="100%">Agus Subagjo</style></author><author><style face="normal" font="default" size="100%">Dandy Hertriwibowo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Left Atrial Myxoma Presented with an Obstructive Shock, Right Ventricle Dysfunction and Pulmonary Hypertension</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Myxoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Obstructive shock</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary hypertension.</style></keyword><keyword><style  face="normal" font="default" size="100%">Right ventricle dysfunction</style></keyword><keyword><style  face="normal" font="default" size="100%">Transthoracic echocardiography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">917-920</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Myxoma is a benign primary cardiac tumour, mostly located in the left atrial. A 43 years old woman was referred with a difficulty of breathing for 3 months. The patients also complained about weakness, swollen legs, enlarged abdomen, and blood-tinged cough. The patient appeared weak with blood pressure of 80/50 mmHg and grade III/IV systolic and diastolic murmurs were found. Transthoracic echocardiography and pathology evaluation conclude a cardiac myxoma. The patient was diagnosed with a LA myxoma with an obstructive shock, right ventricular (RV) dysfunction and pulmonary hypertension, thus a surgical approach was done immediately to prevent embolism and sudden death. Cardiac features are most likely a consequence of obstructed LV inflow. Transthoracic echocardiography is a useful modality to determine the size, location, and mobility of the mass. The persistence of RV dysfunction post-surgical may be due to the chronicity of the myxoma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">917-920</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wisda Medika Valentidenta&lt;sup&gt;1,2,*&lt;/sup&gt;, Agus Subagjo&lt;sup&gt;1,2&lt;/sup&gt; , Dandy Hertriwibowo&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Dr. Soetomo General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Olivia Mahardani Adam</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdan</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mechanism of the Bioactive Sargassum cristaefolium in Inhibiting Inflammatory Mediators in a Nitroglycerin-Induced Migraine Model in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammatory mediator</style></keyword><keyword><style  face="normal" font="default" size="100%">Migraine</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitroglycerin</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum cristaefolium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">388-396</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Migraine headaches are a form of sterile neurogenic inflammation. The sterile inflammatory process of the trigeminal nerve releases the vasoactive neuropeptide CGRP which stimulates the release of inflammatory mediators. In the incidence of migraine there is an increase in TNF-α and IL-10. &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract contains flavonoids, alkaloids, triterpenoids, steroids, and tannins, which has analgesic and anti-inflammatory function. &lt;strong&gt;Method: &lt;/strong&gt;&lt;em&gt;Sargassum cristaefolium &lt;/em&gt;was extracted using maceration method with 70% ethanol as solvent. Animal models were divided into 5 groups and given NTG induction 5 times with 1 day intervals, treated for 3 weeks. All data were analyzed using IBM SPSS version 26.0. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - CGRP levels β: -0.26, p: 0.17; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - CGRP expression β: -0.04, p: 0.85; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - TNF-α levels β: -0.63, p: 0.01; &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract - TNF-α expression β: -0.40, p: 0.04; &lt;em&gt;Sargassum cristaefolium&lt;/em&gt; ethanol extract - IL-10 levels β: 0.77, p: 0.00; &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract - IL-10 expression β: 0.45, p: 0.01.&lt;strong&gt; Conclusions&lt;/strong&gt;: A significant path between the administration of &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract and a decrease in TNF-α and an increase in IL-10. But the effect of giving &lt;em&gt;Sargassum cristaefolium &lt;/em&gt;ethanol extract on CGRP levels did not have a significant relationship.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Olivia Mahardani Adam&lt;sup&gt;1,2&lt;/sup&gt;, Jusak Nugraha&lt;sup&gt;3,*&lt;/sup&gt;, Muhammad Hamdan&lt;sup&gt;4&lt;/sup&gt;, Agus Turchan&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Hang Tuah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Neurology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syeftyan Muhammad Ali Hamami</style></author><author><style face="normal" font="default" size="100%">Michelle Fai</style></author><author><style face="normal" font="default" size="100%">Ahmad Fariduddin Aththar</style></author><author><style face="normal" font="default" size="100%">M Nizam Zulfi Zakaria</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Nikolai Maksimiuk</style></author><author><style face="normal" font="default" size="100%">Nataliya Kulmakova</style></author><author><style face="normal" font="default" size="100%">Evgeniya Latynina</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Oski Illiandri</style></author><author><style face="normal" font="default" size="100%">Khoirun Nisyak</style></author><author><style face="normal" font="default" size="100%">Ernarisa Fitri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Nano transdermal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum sp. .</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">789-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy’s side effects. Fucoidan is an anticancer bioactive compound derived from &lt;em&gt;Sargassum sp&lt;/em&gt;. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from &lt;em&gt;Sargassum sp.&lt;/em&gt; against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and &lt;em&gt;in silico&lt;/em&gt; study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from &lt;em&gt;Sargassum sp&lt;/em&gt;. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">789</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syeftyan Muhammad Ali Hamami&lt;sup&gt;1&lt;/sup&gt;, Michelle Fai&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fariduddin Aththar&lt;sup&gt;1&lt;/sup&gt;, M Nizam Zulfi Zakaria&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;3&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;4&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1,3,&lt;/sup&gt; Dora Dayu Rahma Turista&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8,9&lt;/sup&gt;, Nikolai Maksimiuk&lt;sup&gt;10&lt;/sup&gt;, Nataliya Kulmakova&lt;sup&gt;11&lt;/sup&gt;, Evgeniya Latynina&lt;sup&gt;11&lt;/sup&gt;, ANM Ansori&lt;sup&gt;12&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;13,14,*&lt;/sup&gt;, Riso Sari Mandeli &lt;sup&gt;15&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;16&lt;/sup&gt;, Oski Illiandri&lt;sup&gt;17&lt;/sup&gt;, Khoirun Nisyak&lt;sup&gt;18&lt;/sup&gt;, Ernarisa Fitri&lt;sup&gt;19&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Life Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Veterinary Medicine, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Biomedicine, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Department of Pharmacy, Faculty of Public Health, Universitas Anwar Medika, Sidoarjo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Renan Dilton Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Luz Josefina Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">Melva Iparraguirre-Meza</style></author><author><style face="normal" font="default" size="100%">Mildred Hilda Cóndor- Privat</style></author><author><style face="normal" font="default" size="100%">Beatriz Lilian Galdos-Vadillo</style></author><author><style face="normal" font="default" size="100%">Jenny Mendoza-Vilcahuaman</style></author><author><style face="normal" font="default" size="100%">Rossibel Juana Muñoz-de-la-Torre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Geranium ruizii</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal therapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Pasuchaca</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">315-321</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii &lt;/em&gt;on alloxan-induced hyperglycemia in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;&lt;em&gt;Geranium ruizii&lt;/em&gt; was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (&lt;em&gt;Geranium ruizii &lt;/em&gt;extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;The hypoglycemic effect of the hydroalcoholic extract of &lt;em&gt;Geranium ruizii&lt;/em&gt;, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Renan Dilton Hañari-Quispe&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Josefa Bertha Pari- Olarte&lt;sup&gt;4&lt;/sup&gt;, Luz Josefina Chacaltana-Ramos&lt;sup&gt;4&lt;/sup&gt;, Eddie Loyola-Gonzales&lt;sup&gt;5&lt;/sup&gt;, Melva Iparraguirre-Meza&lt;sup&gt;6&lt;/sup&gt;, Mildred Hilda Cóndor-Privat&lt;sup&gt;6&lt;/sup&gt;, Beatriz Lilian Galdos-Vadillo&lt;sup&gt;6&lt;/sup&gt;, Jenny Mendoza- Vilcahuaman&lt;sup&gt;7&lt;/sup&gt;, Rossibel Juana Muñozde-la-Torre&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rezqi Handayani</style></author><author><style face="normal" font="default" size="100%">Nurul Qamariah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Peel-off Mask Formulation from Stem of Sempeng (Nepenthes gracilis) as Anti Acne Against Propionibacterium acnes Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nepenthes gracilis stem extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Peel-off mask</style></keyword><keyword><style  face="normal" font="default" size="100%">Propinibacterium acnes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">565-570</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Stem of Sempeng (Nepenthes gracilis), which contain saponin and tannin has been known had antibacterial activity against Propionibacterium acnes that usually improve severe of acne. Acne is a skin disease characterized by chronic inflammation in the polisebasca that often occurs in adolescence. &lt;strong&gt;Aims and Objective:&lt;/strong&gt; The aims of this research are to develop and test a peel-off mask prepared from stem of Sempeng extracts, which has antibacterial activity against Propionibacterium acnes. Materials and Methods: Stem of Sempeng was extracted with soxhletation method by ethanol 96%. The extract was formulated into peel-off mask with different extract concentration (0, 1, 5, 10, 15) %. Then the inhibition test of the extract and peel-off mask was measured against bacteria Propionibacterium acnes. The data analysis technique used in this study was to measure the zone diameter on a petri dish using a caliper with a millimeter (mm) unit and presented in tables and photos, the results of the inhibition zone measurement were compared with the classification of the response of the extract barrier to the growth of Clinical and Laboratory Standards Institute (CSLI) standard bacteria.&lt;strong&gt; Results&lt;/strong&gt;: The result showed that the inhibition zone of the peel off mask preparation of sempeng stem extract in F1 and F2 formulations with extract concentrations of 1% and 5% are categorized as resistant, which means that the&lt;em&gt; &lt;/em&gt;&lt;em&gt;Propionibacterium acnes &lt;/em&gt;bacteria has a low level of sensitivity so that a large inhibition zone is not formed. Whereas in the F3 formulation with a concentration of 10% is categorized as an intermediate, which means in this concentration, the mask can inhibit the growth of the inhibition zone &lt;em&gt;Propionibacterium acnes&lt;/em&gt; bacteria which is formed quite well, but in this category it will require repeated use or with high doses of use. Then in the F4 formulation with a concentration of 15%, it is categorized as susceptible, which means the mask have a good inhibitory resistance zone, this shows that the increase in high concentration, the greater the inhibition zone as well. &lt;strong&gt;Conclusion: &lt;/strong&gt;The peel off mask from ethanol extract of Sempeng stem is able to inhibit the growth of&lt;em&gt; Propionibacterium acnes &lt;/em&gt;bacteria. The peel mask preparation with concentration 1%, 5%, 10% and 15% forms a clear zone around the disc which means that this peel off mask formulation has activity to inhibits&lt;em&gt; Propionibacterium&lt;/em&gt; &lt;em&gt;acnes &lt;/em&gt;bacteria and is included in the category of susceptible interpretation according to the CLSI standard.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">12</style></accession-num><section><style face="normal" font="default" size="100%">565</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rezqi Handayani*, Nurul Qamariah&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, Universitas Muhammadiyah Palangkaraya, Palangka Raya, Central Kalimantan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Alejandro Arroyo-Sandoval</style></author><author><style face="normal" font="default" size="100%">Manuel Jesús Marin-Bravo</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Roberto Jesús Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Josefa Bertha Pari-Olarte</style></author><author><style face="normal" font="default" size="100%">Javier Hernán Chávez-Espinoza</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Eddie Loyola-Gonzales</style></author><author><style face="normal" font="default" size="100%">José Santiago Almeida-Galindo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacobotany, Phytochemical Analysis and Anti-inflammatory effect of the Ethanolic Extract of Luffa operculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Luffa operculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Saponins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">622-628</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Luffa operculata&lt;/em&gt; is a vegetable species well known in the traditional peruvian medicine for its many medicinal properties and cosmetic applications.&lt;strong&gt; Objective: &lt;/strong&gt;The aim objective was to determine the pharmacognostic characteristics of&lt;em&gt; L. operculata&lt;/em&gt; as well as observing the pharmacological effect of the ethanol extract of &lt;em&gt;L. operculata&lt;/em&gt; fruit on chronic inflammation in rats. &lt;strong&gt;Materials and Method&lt;/strong&gt;: Phytochemical analysis was carried out by using specific chemical reagents for each constituent chemical, the pharmacobotanical study was done with a histological tinction (fruit, steam and leaves), which were stained with Safranin 1% and Toluidine blue 1%; the chronical inflammation was assessed by air bag method in Holztman male rats. Doses of 100, 250 and 500 mg/Kg were tested in order to determine the anti-inflammatory effect, which was demonstrated with histopathological evaluation and lymphocytes reduction. &lt;strong&gt;Results: &lt;/strong&gt;The main findings indicate that the ethanolic extract presented saponins, alkaloids, carbohydrates, terpenes and steroids. The efficiency of lymphocyte reduction per field in the histopathological study of the granuloma was 58.4% with the middle dose of 250 mg/kg (p &amp;lt; 0.0001), which gives a dose-independent anti-inflammatory effect in rats.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;Luffa operculata &lt;/em&gt;presented anti-inflammatory effect at 250 mg/Kg by oral administration in a chronical experimental model of inflammation in rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">20</style></accession-num><section><style face="normal" font="default" size="100%">622</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Alejandro Arroyo-Sandoval&lt;sup&gt;1&lt;/sup&gt;, Manuel Jesús Marin-Bravo&lt;sup&gt;2&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;3&lt;/sup&gt;, Hugo Jesús Justil-Guerrero&lt;sup&gt;3&lt;/sup&gt;, Roberto Jesús Chávez- Asmat&lt;sup&gt;4&lt;/sup&gt;, Josefa Bertha Pari-Olarte&lt;sup&gt;5&lt;/sup&gt;, Javier Hernán Chávez-Espinoza&lt;sup&gt;5&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;6&lt;/sup&gt;, Eddie Loyola- Gonzales&lt;sup&gt;6&lt;/sup&gt;, José Santiago Almeida- Galindo&lt;sup&gt;7&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;8,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemistry and Chemical Engineering. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Plant Anatomy and Pharmacognosy. Faculty of Biology. Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Section of Neurosurgery, Hospital São Vicente de Paulo. São Paulo, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Basic Sciences, Faculty of Human Medicine, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Departament of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman</style></author><author><style face="normal" font="default" size="100%">Fajar Prasetya</style></author><author><style face="normal" font="default" size="100%">Supriatno Salam</style></author><author><style face="normal" font="default" size="100%">Hifdzur Rashif Rijai</style></author><author><style face="normal" font="default" size="100%">Hadi Kuncoro</style></author><author><style face="normal" font="default" size="100%">Rolan Rusli</style></author><author><style face="normal" font="default" size="100%">Agung Rahmadani</style></author><author><style face="normal" font="default" size="100%">Hady Anshory Tamhid</style></author><author><style face="normal" font="default" size="100%">Kuswandi</style></author><author><style face="normal" font="default" size="100%">Dewanto Harjunowibowo</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile of Simplicia and Ethanolic Leaves Extract from Indonesian Piper betle var. nigra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Black betle</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper betle var. nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">610-618</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Piper betle&lt;/em&gt; var. nigra has potency as an herbal medication. Thus it can be used as a source of medicinal raw materials. &lt;em&gt;Piper betle&lt;/em&gt; var. nigra simplicia and extracts must be controlled to obtain unswerving quality and ensure their pharmacological effects by standardizing them through several specific and non-specific parameters. Specific parameters were analyzed organoleptically in the ethanol extract, namely having a thick consistency, brownish-green or blackish-green color, a mild peculiar odor, a bitter, cherish taste, and a slightly spicy flavor. The microscopic simplicia powder profile is as follows: the lower epidermis with idioblasts in oil cells contour and upper epidermis, sclerenchyma, covering hairs, and transport bundles ladder-type thickening, and idioblasts in oil cells contour. Extract content analysis of simplicia and black betle leaves ethanol extract showed water-soluble extract content of 2.77% and 12.45% and ethanolsoluble extract content of 1.38% and 19.1%. Secondary metabolites in the ethanol extract are flavonoids, polyphenols, tannins, saponins, alkaloids, and steroids. The non-specific parameters of the simplicia and extract are as follows; total ash content of 12.1% and 7.43%; acid insoluble ash content of 4.45% and 1.57%; drying shrinkage of 14.5% and 15.85%; total lead (Pb) contamination 47.5 ppm and 1.2 ppm; and the total cadmium (Cd) contamination &amp;lt;0.2 ppm. The total bacterial contamination in the extract was 4.3x105 colonies/g. The total yeast contamination was 8.3x105 colonies/g and volumetric mass density of the water-soluble extract of 0.96 g/mL and the volumetric mass density of the ethanol-soluble extract of 1.01 g/mL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">610</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman&lt;sup&gt;1,2,*&lt;/sup&gt;, Fajar Prasetya&lt;sup&gt;1,2&lt;/sup&gt;, Supriatno Salam&lt;sup&gt;1,2&lt;/sup&gt;, Hifdzur Rashif Rijai&lt;sup&gt;1,2&lt;/sup&gt;, Hadi Kuncoro&lt;sup&gt;1,2&lt;/sup&gt;, Rolan Rusli&lt;sup&gt;1,2&lt;/sup&gt;, Agung Rahmadani&lt;sup&gt;3&lt;/sup&gt;, Hady Anshory Tamhid&lt;sup&gt;4&lt;/sup&gt;, Dewanto Harjunowibowo&lt;sup&gt;5&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceuticals Research and Development Laboratory of Pharmaca Tropics, Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Chemistry Education, Faculty of Teaching and Education, Mulawarman University, Samarinda 75123, Kalimantan Timur, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Pharmacy, Faculty of Mathematics and Natural Sciences, Islamic University of Indonesia, Jogjakarta 55584, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Physics Education, Universitas Sebelas Maret, Surakarta, 57126, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erna Harfiani</style></author><author><style face="normal" font="default" size="100%">Yudhi Nugraha</style></author><author><style face="normal" font="default" size="100%">Citra Ayu Aprilia</style></author><author><style face="normal" font="default" size="100%">Feda Anisah Makkiyah</style></author><author><style face="normal" font="default" size="100%">Ratna Puspita</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Mirella Fonda Maahury</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Asmi Citra Malina A. R. Tasakka</style></author><author><style face="normal" font="default" size="100%">Alexander Patera Nugraha</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The phytochemical and pharmacological activity of extract Kirinyuh (Chromolaena odorata L.) leaves: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromolaena odorata</style></keyword><keyword><style  face="normal" font="default" size="100%">Kirinyuh</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">580-586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;C. odorata&lt;/em&gt; L. is considered to be a plant weed that is scattered in various climates. As a weed, this plant contains a variety of beneficial secondary metabolites. Several studies have shown the benefits of &lt;em&gt;C. odorata&lt;/em&gt; L. leaf extract. This study reviews the metabolite content and the pharmacological activities of &lt;em&gt;C. odorata&lt;/em&gt; L. leaf extract. A literature search was carried out to obtain various studies related to the use of this plant extract. Secondary metabolites identified in &lt;em&gt;C. odorata&lt;/em&gt; L. are alkaloids, flavonoids, tannins, saponins, and steroids. Several reports have also shown that even though it is considered a weed, &lt;em&gt;C. odorata &lt;/em&gt;L. leaf extract also provides many benefits due to its pharmacological activities. Various pharmacological activities include anti-inflammatory, anti-microbial, antioxidant, antidyslipidemia, hematologic agent, antidiabetic and anti-cataract, analgesic and antipyretic, wound healing, anti-malaria, mosquito larvicidal, antihypercholesterolemia, and antifungal.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">580</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erna Harfiani&lt;sup&gt;1&lt;/sup&gt;, Yudhi Nugraha&lt;sup&gt;2&lt;/sup&gt;, Citra Ayu Aprilia&lt;sup&gt;1&lt;/sup&gt;, Feda Anisah Makkiyah&lt;sup&gt;3&lt;/sup&gt;, Ratna Puspita&lt;sup&gt;4&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;5,6&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;5&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;7&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;8&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;9&lt;/sup&gt;, Mirella Fonda Maahury&lt;sup&gt;10&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;11&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;12&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;12&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;12&lt;/sup&gt;, Asmi Citra Malina A. R. Tasakka&lt;sup&gt;13&lt;/sup&gt;, Alexander Patera Nugraha&lt;sup&gt;14&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;15,16,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology and Pharmacy, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Badan Riset dan Inovasi Nasional, Jakarta, INDONESIA. 3Department of Surgery, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Medical Faculty, UPN Veteran Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pattimura, Ambon, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Candra Irawan</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antioxidant Activity, and Anti- Inflammatory Potential of Rhinachantus nasutus (L.) Kurz Flower Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">2-diphenyl-1-picrylhydrazyl</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">BSA</style></keyword><keyword><style  face="normal" font="default" size="100%">RnK</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">521-526</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims: &lt;/strong&gt;The purpose of this study was to determine the content of the secondary metabolite compound in the flower extract of &lt;em&gt;Rhinachantus nasutus&lt;/em&gt; (L.) Kurz (RnK); The potential of the extract as a radical scavenger of 2,2-diphenyl-1-picrylhydrazyl (DPPH); and its potential as an anti-inflammatory by inhibiting protein denaturation with bovine serum albumin (BSA). &lt;strong&gt;Results: &lt;/strong&gt;Phytochemical screening results on the ethanolic extract of &lt;em&gt;R. nasutus&lt;/em&gt; flowers revealed the presence of steroid glycosides, alkaloids, flavonoids, phenolics, and tannins. The extract has a strong ability to scavenge DPPH radicals with an IC&lt;sub&gt;50 &lt;/sub&gt;value of 77.07 ± 0.05 mg/L. Besides that, the ethanol extract has very strong anti-inflammatory activity, with an IC50 value of 13.88 ± 0.2 mg/L. &lt;strong&gt;Conclusion: &lt;/strong&gt;According to these findings, the ethanolic extract of &lt;em&gt;R. nasutus&lt;/em&gt; flower can be used as an alternative anti-inflammatory drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">521</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Candra Irawan&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Food Nanotechnology, Politeknik AKA Bogor, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Anticancer Activity of Bioactive Compounds from Ipomoea batatas</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumoral.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">650-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ipomoea batatas&lt;/em&gt; L. (Lam.) known as &quot;sweet potato&quot; is a plant species of great importance in the human diet due to the contribution of nutrients and also for its bioactive compounds that have various medicinal properties. Its anticancer activity is one of the properties that attract the attention of researchers in the study of plant species. This review aims to make a critical compilation of current information on research that evaluated the antitumor and antiproliferative activity of &lt;em&gt;Ipomoea batatas. &lt;/em&gt;The studies included in this review show a diversity of bioactive compounds present in&lt;em&gt; Ipomoea batatas&lt;/em&gt; such as phenolic compounds, anthocyanins, flavonoids, coumarins and sterols; also isolated compounds such as pectin, peptides and glycoproteins that can be related to their biological activity. It is concluded that there are positive results about &lt;em&gt;Ipomoea batatas&lt;/em&gt; and its anticancer activity evaluated through in vitro and &lt;em&gt;in vivo &lt;/em&gt;tests. In humans, safety and efficacy trials are still lacking to support its future use and allow drug development. Further research evaluating the safety and efficacy of reported bioactive compounds in &lt;em&gt;Ipomoea batatas &lt;/em&gt;is important for the development of this promising area.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">24</style></accession-num><section><style face="normal" font="default" size="100%">650</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,*&lt;/sup&gt;, Julio Hilario- Vargas&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;3&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yulius Baki Korassa</style></author><author><style face="normal" font="default" size="100%">Nyi Mekar Saptarini</style></author><author><style face="normal" font="default" size="100%">Resmi Mustarichie</style></author><author><style face="normal" font="default" size="100%">Rini Hendriani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential of Moringa (Moringa oleifera Lamk) Seed Oil as Anti- Alopecia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-alopecia</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acids</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa Seed Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">379-387</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This review article aimed to examine the potentiality of moringa seed oil as anti-alopecia. &lt;strong&gt;Method:&lt;/strong&gt; The data was collected by studying national and international journal articles using several search engines, namely Google and Google Scholar websites, Research Gate, Sciencedirect and Scimagojr. The keywords for this article include moringa seed oil, fatty acids, phytosterol, and anti-alopecia.&lt;strong&gt; Results: &lt;/strong&gt;The result was tabulated in a table and described according to the mechanism of action of the active compounds found in moringa seed oil, fatty acids, phytosterol, and anti-alopecia. Moringa seed oil contain the phytosterol compounds (β-sitosterol, ergosterol and campesterol) show the activities that obstruct the formation of the dihydrotestosterone (DHT) compound known to be the cause of alopecia. The fatty acid compounds found in moringa seed oil (lauric acid, linoleic acid, palmitoleic acid, palmitic acid, and oleic acid) reinforce its potential to be an anti-alopecia. &lt;strong&gt;Conclusion&lt;/strong&gt;: The phytosterol and fatty acid compounds supported the growth of hair to be fertile and healthy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">379</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yulius Baki Korassa&lt;sup&gt;1,2&lt;/sup&gt;, Nyi Mekar Saptarini&lt;sup&gt;1,*&lt;/sup&gt;, Resmi Mustarichie&lt;sup&gt;1&lt;/sup&gt;, Rini Hendriani&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran. Jl. Raya Bandung Sumedang, Jatinangor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy Study Program, Health Polytechnic of Ministry of Health in Kupang, Jl. Piet A. Tallo, Liliba, Kupang – East Nusa Tenggara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology &amp;amp; Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran. Jl. Raya Bandung Sumedang, Km. 21 Jatinangor 45363&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Candra Irawan</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential of Rhinachanthus nasutus (L.) Kurz Leaves Extract as an Antioxidant and Inhibitor of α-Glucosidase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">CUPRAC method</style></keyword><keyword><style  face="normal" font="default" size="100%">RnLK</style></keyword><keyword><style  face="normal" font="default" size="100%">UAE</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">373-378</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; The goal of this study is to learn more about the antioxidant and antidiabetic properties of&lt;em&gt; Rhinachantus nasutus &lt;/em&gt;(L.) Kurz (RnLK) leaf extract. The Ultrasound-Assisted Extraction (UAE) technique was used to extract the leaf material, and the solvent used was ethanol with a 70% concentration. The total phenol content (TPC) of the extracted material was determined. The Cupric Ion Reducing Antioxidant Capacity (CUPRAC) method was used to examine antioxidant activity, whereas α-glucosidase activity was used to test antidiabetic action.&lt;strong&gt; Results:&lt;/strong&gt; The ethanol extract of RnLK leaves yielded 8.36%, with a TPC of 607.1±0.2 mg GAE/g sample. The IC&lt;sub&gt;50&lt;/sub&gt; value for leaf extract antioxidant activity was 19.1±0.1 mg/L. Furthermore, the leaf extract inhibits α-glucosidase activity and has an IC&lt;sub&gt;50&lt;/sub&gt; value of 81.3±3 mg/L, making it an antidiabetic. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanolic extract of RnLK leaves can be used as an alternative antioxidant and antidiabetic material, according to the findings of this study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><accession-num><style face="normal" font="default" size="100%">18</style></accession-num><section><style face="normal" font="default" size="100%">373</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Candra Irawan&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;3&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Food Nanotechnology, Politeknik AKA Bogor, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agniya Ali Fahmi Hikmat</style></author><author><style face="normal" font="default" size="100%">Mia Ratwita Andarsini</style></author><author><style face="normal" font="default" size="100%">Bagus Setyoboedi</style></author><author><style face="normal" font="default" size="100%">Maria Christina Shanty Larasati</style></author><author><style face="normal" font="default" size="100%">Andi Cahyadi</style></author><author><style face="normal" font="default" size="100%">I Dewa Gede Ugrasena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk Factors for Hepatotoxicity From L-Asparaginase Chemotherapy In Children With Acute Lymphoblastic Leukemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute lymphoblastic leukemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Children</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">L-asparaginase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">921-927</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; L-asparaginase chemotherapy often causes hepatotoxicity and affects complete remission in pediatric acute lymphoblastic leukemia (ALL). This study aims to investigate the risk factors that affect the incidence of hepatotoxicity caused by L-asparaginase chemotherapy in ALL children. &lt;strong&gt;Methods:&lt;/strong&gt; An observational study with prospective sampling was conducted at Dr. Soetomo Hospital, Surabaya. The inclusion criteria included ALL children aged 1-18 years, undergoing ALL Induction phase chemotherapy based on the 2018 Indonesian Children's ALL protocol as evidenced by bone marrow aspiration, receiving L-asparaginase chemotherapy, and obtaining written consent from parents or guardians. Each child had 3 ml of blood drawn from a peripheral vein to assess their complete blood count, alanine transaminase (ALT) levels, and albumin level. &lt;strong&gt;Results:&lt;/strong&gt; Thirty-two children with ALL were collected. Two of them were excluded due to allergic reaction and enable to continue the L-asparaginase chemotherapy. Thirty of them were eligible participants. Approximately 53.3% of ALL children aged ≤ seven years. Fourteen (47%) children with ALL were included in the standard-risk group and 16 (53%) of them included high-risk group. There were significant differences in ALT levels between the four stages of observation (p=&amp;lt;0.001). Twenty-two ALL children had hepatotoxicity (73.3%), while 8 had non-hepatotoxicity (26.7%). Two risk factors had a significant influence on the occurrence of hepatotoxicity due to L-asparaginase chemotherapy including age and hypoalbuminemia (p=0.045, p=0.028). &lt;strong&gt;Conclusion:&lt;/strong&gt; Age and hypoalbuminemia were the risk factors that might affect the incidents of hepatotoxicity. Clinical monitoring before and after treatment needs to be done to prevent poor outcomes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">921</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agniya Ali Fahmi Hikmat&lt;sup&gt;1&lt;/sup&gt;, Mia Ratwita Andarsini&lt;sup&gt;1,2,*&lt;/sup&gt;, Bagus Setyoboedi&lt;sup&gt;1,2&lt;/sup&gt;, Maria Christina Shanty Larasati&lt;sup&gt;1,2&lt;/sup&gt;, Andi Cahyadi&lt;sup&gt;1,2&lt;/sup&gt;, I Dewa Gede Ugrasena&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Child Health, Faculty of Medicine Universitas Airlangga, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Dr. Soetomo General Academic Teaching Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ditya Indrawati</style></author><author><style face="normal" font="default" size="100%">Linda Astari</style></author><author><style face="normal" font="default" size="100%">Afif Nurul Hidayati</style></author><author><style face="normal" font="default" size="100%">Sawitri, Damayanti</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Bagus Haryo Kusumaputra</style></author><author><style face="normal" font="default" size="100%">Medhi Denisa Alinda</style></author><author><style face="normal" font="default" size="100%">Cita Rosita Sigit Prakoeswa</style></author><author><style face="normal" font="default" size="100%">M. Yulianto Listiawan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Risk Factors of Acute and Chronic Erythema Nodosum Leprosum in Dr. Soetomo General Academic Hospital Surabaya</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute ENL</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic ENL</style></keyword><keyword><style  face="normal" font="default" size="100%">ENL</style></keyword><keyword><style  face="normal" font="default" size="100%">Leprosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Neglected disease.</style></keyword><keyword><style  face="normal" font="default" size="100%">Risk factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">766-770</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Leprosy is a chronic granulomatous infection and is one of the neglected diseases caused by &lt;em&gt;Mycobacterium leprae.&lt;/em&gt; ENL is a complex syndrome, that caused inflammation of the skin, nerves, and other organs due to an inflammatory immune response to &lt;em&gt;Mycobacterium leprae &lt;/em&gt;antigens. Acute ENL was defined as the first episode of ENL with a duration of less than 24 weeks. Chronic ENL was defined as ENL that persisted for more than 24 weeks. These types of ENL can have different risk factors and require different therapeutic interventions. Purpose: The onset of ENL is acute, but may progress to a chronic or recurrent phase and require long-term therapy. Early detection of leprosy is very important, because the infection is curable and prompt treatment can reduce nerve damage and associated stigma. Chronic ENL patients require prolonged high doses of corticosteroids to control inflammation in ENL and cause severe complications and side effects associated with morbidity and mortality.&lt;strong&gt; Methods: &lt;/strong&gt;This retrospective study was conducted using a non-probability sampling technique consecutively using a casecontrol formula in leprosy patients with ENL in the Leprosy Division of the Outpatient Dermatology and Venereology Unit RSUD Dr. Soetomo Surabaya for the period 2015 – 2020, using secondary data in the form of medical record data.&lt;strong&gt; Result: &lt;/strong&gt;The results of this study obtained leprosy patients with ENL as many as 234 patients, 56 patients with acute ENL and 89 patients with chronic ENL. 45 patients with acute ENL and 45 patients with chronic ENL were obtained from the case-control minimal sample size formula. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of the bivariate analysis test showed that there was a relationship between risk factors for coinfection and steroid therapy with the type of ENL. The presence of coinfection and steroid therapy showed that patients tend to be chronic ENL, conversely, in the absence of coinfection and without steroid therapy, patients tend to be acute ENL. The multivariate logistic regression analysis test showed a significant association between risk factors for ENL onset before MDT and the presence of coinfection with chronic ENL, whereas ENL onset after MDT and absence of coinfection were associated with acute ENL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">766</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ditya Indrawati, Linda Astari, Afif Nurul Hidayati, Sawitri, Damayanti, Budi Utomo, Bagus Haryo Kusumaputra, Medhi Denisa Alinda, Cita Rosita Sigit Prakoeswa, M. Yulianto Listiawan*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Resident of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Akram A Hammo</style></author><author><style face="normal" font="default" size="100%">Abdulla A Ahmad</style></author><author><style face="normal" font="default" size="100%">Zeina A Althanoon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Role of Gender in the Protection Against Doxorubicin-Induced Oxidative Stress</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Coenzyme Q10</style></keyword><keyword><style  face="normal" font="default" size="100%">Doxorubicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Gender difference</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">782-788</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There are gender differences in the oxidation-reduction reactions. Doxorubicin (Dox) is a chemotherapeutic drug that can produce oxidative stress which may require prevention by antioxidants. Aim: The study aimed to investigate the gender-dependent changes in Dox-induced oxidative stress, and the protective effects of coenzyme Q10 (CoQ10).&lt;strong&gt; Materials and Methods&lt;/strong&gt;: Rats were administered CoQ10 orally for 17 days. On day 13, some rats receiving CoQ10 received a single intraperitoneal dosage of Dox, whereas other rats received normal saline. Glutathione (GSH), malondialdehyde (MDA), and total anti-oxidant capacity (T-AOC) were measured in both genders of albino rats. &lt;strong&gt;Results&lt;/strong&gt;: Dox significantly reduced both GSH and T-AOC levels and caused a significant increase in MDA. The administration of CoQ10 significantly prevented these changes. Dox caused a larger reduction in GSH in males than in females, while CoQ10 caused more protection in females. Dox caused a higher increase in MDA levels in males.&lt;strong&gt; Conclusion:&lt;/strong&gt; Pre-treatments with CoQ10 may protect against Dox-induced oxidative stress, with gender-dependent variations in the extent of these Dox/CoQ10 effects.&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">782</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Akram A Hammo&lt;sup&gt;1&lt;/sup&gt;, Abdulla A Ahmad&lt;sup&gt;2,*&lt;/sup&gt;, Zeina A Althanoon&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;The primary health care sector in Al-Baaj, Nineveh Health Directorate, Ministry of Health, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of clinical and laboratory sciences, College of Pharmacy, University of Mosul, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of pharmacology and toxicology, College of Pharmacy, University of Mosul, IRAQ&lt;/p&gt;
&lt;quillbot-extension-portal&gt;&lt;/quillbot-extension-portal&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Qamariah</style></author><author><style face="normal" font="default" size="100%">Rezqi Handayani</style></author><author><style face="normal" font="default" size="100%">Jessika Maretania</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Serum Formulation of Hati Tanah Tuber Ethanol Extract from Central Kalimantan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Formulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Hati Tanah Tuber Ethanol Extract.</style></keyword><keyword><style  face="normal" font="default" size="100%">Serum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">978-982</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Lately, the use of natural cosmetics can have a good effect on the skin. One of them is traditional beauty treatments. The Serum is a preparation with low viscosity, because of its low viscosity serum is categorized as an emulsion preparation. From the results of research that has been carried out, ethanol extract of Hati Tanah tuber has great potential as an anti-acne because it can inhibit the growth of acne-causing bacteria such as&lt;em&gt; Staphylococcus aureus, Staphylococcus epidermidis, Propionibacterium acnes.&lt;/em&gt; With the innovation of serum ethanol extract of Hati Tanah tuber, it can be an option for the community later in the treatment of acne. &lt;strong&gt;Methods:&lt;/strong&gt; The formulation is made in 4 (four) formulas with different concentrations of the main ingredients used. Next is to weigh all the ingredients needed according to each formula. Then physical properties test performed. a) Organoleptic test; b) Homogeneity Test; c) pH test; d) Spreadability Test and e) Adhesion Test. &lt;strong&gt;Results: &lt;/strong&gt;The organoleptic test was carried out directly by looking at the shape and color and smelling the serum preparation of the ethanol extract of Tanah Hari tubers. The test results show that at F0 (0%) the color is clear, for F1 (0,5%) it is quite pale pink, F2 (1%) is bright pink and F3 (5%) is dark red. For scent organoleptic, F0 indicates no scent, for F1 and F2 there is a distinctive scent from the Hati Tanah tuber which is slightly pungent, while F3 shows a pungent aroma typical of the Hati Tanah tuber. The resulting serum has a thick texture at F0 and F1, a watery texture at F2 and a thinner texture at F3. All of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test.&lt;strong&gt; Conclusion: &lt;/strong&gt;The simplicia of Hati Tanah tuber can be made into an innovative cosmetic preparation in the form of serum with a concentration of 0,5%, 1% and 5%. From the results of testing the physical properties of the formulations, all of the formulas have met the physical test requirement of organoleptic properties, homogeneity, pH, and adhesion test.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">978</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurul Qamariah*, Rezqi Handayani, Jessika Maretania&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, Universitas Muhammadiyah Palangkaraya, Palangka Raya, Central Kalimantan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Rahmad Abdillah</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Hafifah Hardini</style></author><author><style face="normal" font="default" size="100%">Khalila Tri Syahbani Zuler</style></author><author><style face="normal" font="default" size="100%">Aditya Alqamal Alianta</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subacute Toxicity Test of Hydrocotyle Sibthorpioides Lam. Extract on Histopathological Images of Liver and Kidney of White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">619-626</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Hydrocotyle sibthorpioides&lt;/em&gt; Lam. in Indonesia known as pegagan embun. It has been used to increase the immune system and has been shown to have immunostimulating, anti-inflammatory and hematopoietic effects. However, there is no scientific evidence that shows this plant is safe for long-term use. Based on that circumstance, this study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Aim:&lt;/strong&gt; The study aimed to measure the safety of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam.) ethanol extract activities on liver and kidney histopathology. &lt;strong&gt;Material and Method&lt;/strong&gt;: Ethanol extract used because all the active compounds in plants extracted as a whole, and it cheaper and more efficient in the extraction process. Determine as many thirty-six white male mice as test animals and separate them into eight treatment groups. The administrated ethanol extract of Pegagan Embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) at doses of 7, 35, and 150 mg/kg BW for 7, 14, and 21 days. On days 8&lt;sup&gt;th&lt;/sup&gt;, 15&lt;sup&gt;th&lt;/sup&gt;, and 22&lt;sup&gt;nd&lt;/sup&gt;, three white male mice collected from each treatment group and collected their liver and kidney. The data analysed used a T-test with IBM SPSS type 24. &lt;strong&gt;Result: &lt;/strong&gt;LD50 of ethanol extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. &amp;gt; 15,000 mg/kg means practically not toxic. The results showed that the administration of extract &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. for 7, 14, and 21 days showed a non-significant effect on any histological damage to the liver of male white mice at doses of 7 and 35 mg/kg BW (normal histology). The non-significant effect also occurs at150 mg/kg BW for 7 days; however, it caused mild damage at a dose of 150 mg/kg BW for 14 days and moderate damage at 150 mg/kg BW for 21 days. In renal histopathology, doses of 7 mg/kg BW. for 7, 14, and 21 days showed normal histology and doses of 35 mg/kg BW for 7, 14, and 21 days showed minimal damage. The administration at doses of 150 mg/kg BW for 7 days showed mild damage, while a dose of 150 mg/kg BW for 14 and 21 days showed moderate damage. &lt;strong&gt;Conclusion:&lt;/strong&gt; It concluded that the administration of extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. did not cause severe damage to the histology of the liver and kidneys of white male mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">619</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1&lt;/sup&gt;, Rahmad Abdillah&lt;sup&gt;2&lt;/sup&gt;, Elidahanum Husni&lt;sup&gt;3&lt;/sup&gt;, Hafifah Hardini&lt;sup&gt;4&lt;/sup&gt;, Khalila Tri Syahbani Zuler&lt;sup&gt;4&lt;/sup&gt;, Aditya Alqamal Alianta&lt;sup&gt;5&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;6,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;lecturer in the Department of Physiology also as the Dean of Faculty of Medicine Universitas Andalas, Dean at the Faculty of Dentistry of Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;lecturer in Department of Biology of Pharmacy, Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Profession student in Pharmacist Program at Faculty of Pharmacy, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;lecturer in Department on Socio-economic Animal Science, Faculty of Animal Science, Universitas Andalas, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;lecturer in Department of Pharmacology, Faculty of Pharmacy, Universitas Andalas, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sesilia Rante Pakadang</style></author><author><style face="normal" font="default" size="100%">St. Ratnah</style></author><author><style face="normal" font="default" size="100%">Alfrida Monica Salasa</style></author><author><style face="normal" font="default" size="100%">Jumain</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Toll Like Receptor 4 Expression Profile in Mice Infected Mycobacterium Tuberculosis Given with Miana Leaves Extract (Coleus scutellarioides (L.) Benth) (Tuberculosis Preventive and Curative Mechanisms)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antituberculosis.</style></keyword><keyword><style  face="normal" font="default" size="100%">Miana Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR-4</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">497-505</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Tuberculosis is an infectious disease of the respiratory tract caused by Mycobacterium tuberculosis. During Mycobacterium tuberculosis infection, pathogens modulate TLR-4 receptor flow signaling, suggesting possible involvement of TLR-4 in the regulation of the host immune response. This study aims to determine the effect of miana leaf extract on the expression of toll like receptor 4 (TLR-4) in tuberculosis mice at the preventive and curative stages. &lt;strong&gt;Methods:&lt;/strong&gt; Mice were divided into 3 groups with 7x replication. Providing 14 days of preventive treatment, 14 days of incubation and 14 days of curative treatment. Group 1 and group 3 were given Miana Leaves Extract (EDM) and placebo at all three stages. Group 2 was given EDM at the preventive and incubation stages, then they were given anti-tuberculosis drugs (OAT). &lt;strong&gt;Results: &lt;/strong&gt;The results proved that EDM given as a preventive did not increase the expression of TLR-4 protein in healthy mice; Changes in expression of TLR-4 protein in M.tb-infected mice before and after curative EDM increased by 17%, after administration of placebo increased 97% and decreased 12% after OAT curative administration; Changes in expression of TLR-4 protein in M.tb-infected mice before preventive administration and after EDM curative administration increased by 20%, after administration of placebo increased 102% and decreased by 10% after the curative administration of OAT.&lt;strong&gt; Conclusions: &lt;/strong&gt;EDM has potential as antituberculosis with TLR-4 regulatory mechanism.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><accession-num><style face="normal" font="default" size="100%">03</style></accession-num><section><style face="normal" font="default" size="100%">497</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sesilia Rante Pakadang&lt;sup&gt;1,*&lt;/sup&gt;, St. Ratnah&lt;sup&gt;1&lt;/sup&gt;, Alfrida Monica Salasa&lt;sup&gt;1&lt;/sup&gt;, Jumain&lt;sup&gt;1&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Makassar Health Polytechnic Ministry of Health, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Hasanuddin University Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lukman La Basy</style></author><author><style face="normal" font="default" size="100%">Djoko Santosa</style></author><author><style face="normal" font="default" size="100%">Retno Murwanti</style></author><author><style face="normal" font="default" size="100%">Triana Hertiani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Uncover Itchy Leaves Ethnomedicine Usage: A Preliminary Study on Characterization and Bioactivity of Laportea Spp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Cox-2 inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH radical scavenging activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Itchy leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea decumana (Roxb.) Wedd</style></keyword><keyword><style  face="normal" font="default" size="100%">Laportea stimulans (L.f.) Gaud</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical profiles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">286-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Laportea decumana&lt;/em&gt; (Roxb.) Wedd. and &lt;em&gt;Laportea&lt;/em&gt; stimulans (L.f.) Miq. (Urticaceae) or itchy leaves are endogenous plants from The Maluku Islands, Indonesia, which are used topically as analgesics by local people.&lt;strong&gt; Objective&lt;/strong&gt;: As part of a preliminary investigation on the itchy leaves, this study was conducted to provide information on their macroscopic and microscopic characteristics, phytochemical profiles, and bioactivities according to the ethnomedicinal usages. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The macroscopic examination was carried out on fresh leaves. The microscopic examination was carried out on leaf powder under a light microscope. The phytochemical analyses using TLC were conducted on those crude extracts and fractions. The bioactivity assays were conducted&lt;em&gt; in vitro&lt;/em&gt; as Cox-2 inhibitory and DPPH radical scavenging activities. Results: reveal similar characteristics in the macroscopic and microscopic properties of both &lt;em&gt;Laportea &lt;/em&gt;spp. leaves. Calcium oxalate crystals were observed in&lt;em&gt; L. decumana&lt;/em&gt; but not found in &lt;em&gt;L. stimulans.&lt;/em&gt; Both species have stomata with anisocytic type. More trichomes are found in the leaves of&lt;em&gt; L. decumana,&lt;/em&gt; yet smaller and easily detachable. TLC analyses exhibited slightly different profiles. The crude extracts and fractions at 10 μg/ml showed similar inhibitory percentages on Cox-2. The DPPH scavenging activities of the crude extracts and fractions of&lt;em&gt; L. decumana &lt;/em&gt;showed active moderate activity with an IC50 value &amp;lt; 250 μg/ml, while those of &lt;em&gt;L. stimulans&lt;/em&gt; showed moderate to weak potency with an IC50 value &amp;lt; 500 μg/ml. &lt;strong&gt;Conclusion: &lt;/strong&gt;Further exploration on Laportea spp. pharmacological activity is recommended to provide stronger evidence for its ethnomedicinal usage.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">06</style></accession-num><section><style face="normal" font="default" size="100%">286</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lukman La Basy&lt;sup&gt;1,2&lt;/sup&gt;, Djoko Santosa&lt;sup&gt;3&lt;/sup&gt;, Retno Murwanti&lt;sup&gt;4&lt;/sup&gt;, Triana Hertiani&lt;sup&gt;3,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Sciences Doctoral Study Program, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy Department, Stikes Maluku Husada, Maluku 97566, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fathul Djannah</style></author><author><style face="normal" font="default" size="100%">Muhammad Nasrum Massi</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">Agussalim Bukhari</style></author><author><style face="normal" font="default" size="100%">Irda Handayani</style></author><author><style face="normal" font="default" size="100%">Muhammad Faruk</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Virgin coconut oil and tuberculosis: A mini-review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Mycobacterium tuberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Tuberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Virgin coconut oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">464-469</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Virgin coconut oil is widely promoted and used as healthy and beneficial oil. One of them is caused by antimicrobials. Caprylic, caproic acid, capric acid, lauric acid and tau glyceryl monolaurate are other VCO compositions. Furthermore, due to the non-heating manufacturing process, the content in VCO can reduce cholesterol levels of triglycerides, LDL, phospholipids, VLDL and increase HDL in blood serum. VCO consumption lowers the number of&lt;em&gt; Mycobacterium tuberculosis &lt;/em&gt;colonies while increasing the conversion of BTA sputum. Until now, the prevalence of tuberculosis (TB) disease was extremely high. VCO can be used as a supplement to help TB patients recover faster.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Mini-Review</style></work-type><section><style face="normal" font="default" size="100%">464</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fathul Djannah&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Nasrum Massi&lt;sup&gt;2&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;, Agussalim Bukhari&lt;sup&gt;3&lt;/sup&gt;, Irda Handayani&lt;sup&gt;4&lt;/sup&gt;, Muhammad Faruk&lt;sup&gt;5&lt;/sup&gt;, Anny Setijo Rahaju&lt;sup&gt;6,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Mataram, Mataram, West Nusa Tenggara INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Nutrition, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Surgeon, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universitas Airlangga Academic Hospital, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Cut Mauliza</style></author><author><style face="normal" font="default" size="100%">Ester Hidayati</style></author><author><style face="normal" font="default" size="100%">Ita Anggraini</style></author><author><style face="normal" font="default" size="100%">Riska Anggraini</style></author><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Acute Toxicity of Ki Hampelas Leaves (Sterculia rubiginosa Zoll. Ex Miq)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ki Hampelas ( Sterculia rubiginosa Zoll. Ex Miq)</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">570-576</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Ki Hampelas (&lt;em&gt;Sterculia rubiginosa&lt;/em&gt; Zoll. Ex Miq) is a medicinal plant with antioxidant and nephroprotective activity. &lt;strong&gt;Objective:&lt;/strong&gt; This research aims to prove that Ki Hampelas leaves extract through an acute toxicity test. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;This study used white male rats of the&lt;em&gt; Sprague-Dawley&lt;/em&gt; strain divided into four groups, the normal group and the 50 mg/ kg, 1000 mg/kg, 2000 mg/kg dose groups. For the acute toxicity test, a single dose with an observation of 14 days. After that, the surgery was done to see changes in the histopathology of the liver and kidneys. &lt;strong&gt;Results: &lt;/strong&gt;The administration of Ki Hampelas leaf extract in the acute toxicity test did not cause death in the tested animals. There were no significant liver and kidney changes seen from the SGOT, SGPT, creatinine, urea, and histopathology. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ki Hampelas leaves extract did not cause death and toxic effects in the acute toxicity test.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">570</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rini Prastiwi*, Ema Dewanti, Cut Mauliza, Ester Hidayati, Ita Anggraini, Riska Anggraini, Vera Ladeska&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;University of Mu- hammadiyah Prof. Dr. Hamka, Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karnirius Harefa</style></author><author><style face="normal" font="default" size="100%">Delmi Sulastri</style></author><author><style face="normal" font="default" size="100%">Ellyza Nasrul</style></author><author><style face="normal" font="default" size="100%">Syafruddin Ilyas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Several Inflammatory Markers Expression in Obese Rats given Plectranthus amboinicus (Lour.) Spreng Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Enzyme-Linked Immunosorbent Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Obese</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">172-178</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Oxidative stress is one of the inflammatory events caused by obesity. This condition is characterized by an increase in various inflammatory markers, such as intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and a cluster of differentiation 40 (CD40). This study aimed to analyze the effect of Plectranthus amboinicus (Lour.) Spreng ethanol extract on ICAM-1, VCAM-1, and CD40 in obese rats. &lt;strong&gt;Methods: &lt;/strong&gt;The study used a pure experimental method with a completely randomized design. There were 6 groups, namely, C− (negative control), C+ (positive control), CMC (soluble control), EE300 (P. amboinicus ethanol extract, 300 mg/kg body weight [BW]), EE600 (P. amboinicus ethanol extract, 600 mg/kg BW) and EE900 groups (P. amboinicus ethanol extract, 900 mg/kg BW). &lt;strong&gt;Results: &lt;/strong&gt;The results showed low levels of ICAM-1 and VCAM-1 in the blood plasma, especially in the EE900 group, but the difference was not substantial. The same trend also occurred in the expression of CD40 in the tunica intima layer of the rat aorta. &lt;strong&gt;Conclusions:&lt;/strong&gt; Thus, the administration of 900 mg/kg BW P. amboinicus ethanol extract for 45 days has the potential to treat obesity in rats through the suppression of oxidative stress and inflammatory markers (ICAM-1, VCAM-1 and CD40).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">172</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Karnirius Harefa&lt;sup&gt;1&lt;/sup&gt;, Delmi Sulastri&lt;sup&gt;1&lt;/sup&gt;, Ellyza Nasrul&lt;sup&gt;1&lt;/sup&gt;, Syafruddin Ilyas&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Programme of Biomedic, Faculty of Medicine, Universitas Andalas, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences,Universitas Sumatera Utara, Medan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Wardatun</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Noorwati Sutandyo</style></author><author><style face="normal" font="default" size="100%">Abdul Mun'im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analyzing of Urine 3-Hidroxy Propil Mercapturic Acid on Cyclophosphamide Induced Rat to Determine Ameliorating Effect of Leucaena leucocephala (Lam.) de Wit Seed Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-Hidroxypropil mercapturic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyclophosphamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Leucaena leucocephala (Lam.) de Wit</style></keyword><keyword><style  face="normal" font="default" size="100%">Urine.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1549-1556</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;A 70% ethanolic extract of&lt;em&gt; Leucaena leucocephala &lt;/em&gt;(Lam.) de Wit seeds contain a certain amount of sulfhydryl active compounds and potential for ameliorated cyclophosphamide side effects. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study was to analyze of urine 3-hidroxy propil mercapturic acid (3-HPMA) in a rat model for cyclophosphamide-induced hemorrhagic cystitis to determine the effect of&lt;em&gt; Leucaena leucocephala &lt;/em&gt;(Lam.) de Wit seeds extract.&lt;strong&gt; Materials and methods:&lt;/strong&gt; The levels of urine 3-hidroxy propil mercapturic acid was measured using LCMS/MS. Urine preparation was carried out by dilution (1:5) with mobile phase and contained a deuteurated internal standard. The LC separation was performed using a C18 column (1.7 μm; 2.1 mm × 100 mm). The mobile phase consisted of formic acid (0.1%) and formic acid (0.1%) in acetonitrile (90:10 v/v), as a starting gradient at flow rate of 0.2 ml/min with total run 7 min. &lt;strong&gt;Results: &lt;/strong&gt;The lower limit of quantification was 40 ng/ml and the linear extended to 20,000 ng/ml. The method has been successfully to be applied in determined of rat urine 3-HPMA. The results showed that the 70% ethanolic extract of seeds can increased the amount of 3-HPMA in rat urine. &lt;strong&gt;Conclusion:&lt;/strong&gt; The 70% ethanolic extract of seeds displayed a potential ameliorating effect against cyclophosphamide side effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Wardatun&lt;sup&gt;1,2&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;1,3&lt;/sup&gt;,*, Noorwati Sutandyo&lt;sup&gt;4,5&lt;/sup&gt;, Abdul Mun'im&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Program Study of Pharmacy, Universitas Pakuan, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Republic of Indonesia Defense University, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dharmais, Cancer Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Dani Sujana</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author><author><style face="normal" font="default" size="100%">Mareetha Zahra Shafirany</style></author><author><style face="normal" font="default" size="100%">Lela Sulastri</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Farhamzah</style></author><author><style face="normal" font="default" size="100%">Anggun Hari Kusumawati</style></author><author><style face="normal" font="default" size="100%">Nia Yuniarsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity of Extract and Fractions of Castanopsis costata Leaves on Alloxan-induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1589-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In North Sumatra, Castanopsis costata is commonly used by traditional practitioners for the treatment of diabetes mellitus, however, no studies have been carried out to substantiate this practice. Therefore, this study aims to evaluate the anti-diabetic activity of extract and fractions of C. costata leaves in mice with alloxan-induced diabetes. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss albino mice with alloxan-induced diabetes, were acquired and subjected to the experimental evaluations. Subsequently, the fasting blood glucose levels of the diabetic mice groups treated with glibenclamid, extract and fractions, as well as the untreated group, were evaluated after two weeks of therapy. &lt;strong&gt;Results: &lt;/strong&gt;Based on the results, the ethanolic extract of C. costata considerably reduced the mice’s blood glucose levels in a dose-dependent manner, at dosages of 25, 50, 100, and 200 mg/kgBW (% DBGL: 21.10%, 46.36%, 58.94%, and 60.93%, respectively). In addition, the water fraction of C. costata leaves produced a greater reduction in blood glucose levels (% DBGL: 78.93%), compared to the ethyl acetate and n-hexane fractions (% DBGL: 67.06% and 58.83%), respectively. Meanwhile, treatment with the antidiabetic drug, glibenclamide (5 mg/kgBW) produced a 50.75% reduction in blood glucose levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the findings, the extract and fractions of C. costata leaves were concluded to exhibit significant anti-diabetic activity. This supported the claim that traditional practitioners in North Sumatra use the plant extract for diabetes treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1589</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Dani Sujana&lt;sup&gt;2&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;2&lt;/sup&gt;, Mareetha Zahra Shafirany&lt;sup&gt;3&lt;/sup&gt;, Lela Sulastri&lt;sup&gt;4&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Farhamzah&lt;sup&gt;1&lt;/sup&gt;, Anggun Hari Kusumawati&lt;sup&gt;1&lt;/sup&gt;, Nia Yuniarsih&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Buana Perjuangan Karawang University, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitri Santy Budiarso</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Andy Howard Limengan</style></author><author><style face="normal" font="default" size="100%">Ratika Rahmasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of Methanol Fractions Stem Bark of Kayu Sarampa (Xylocarpus moluccensis (Lam.) M. Roen))</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant.</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Kayu Sarampa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1694-1701</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Methanol extract of X. moluccensis was found to be significantly effective in scavenging DPPH method. Therefore, this research is a follow-up research study from Budiarso et al (2020).. The methanol extract was then fractionated and tested for antioxidant activity. &lt;strong&gt;Objective:&lt;/strong&gt; To assess antioxidants activity of methanolic fractions from stem bark of Kayu Sarampa. &lt;strong&gt;Method:&lt;/strong&gt; The Stem bark was extracted with Reflux method using hexane, ethyl acetate, and methanol as solvent. The methanolic extract was fractionated using a chromatographic column were subjected to the antioxidant activity assay by the 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and the ferric-reducing antioxidant power (FRAP) method. &lt;strong&gt;Results: &lt;/strong&gt;F3 Fractions IC&lt;sub&gt;50&lt;/sub&gt; of &lt;em&gt;X. moluccensis &lt;/em&gt;exhibits the highest DPPH scavenging activity compared with F2, F3, ascorbic acis as control positif, F5, and F4, wich are 4.64, 6.79, 9.69, 10.49, and 227.44 respectively and Ferric reducing power from methanolic fraction of &lt;em&gt;X. moluccensis&lt;/em&gt; stembark F3 exhibits higher antioxidant power compared to F2, F1, F5, ascorbic acid and F4, respectively which are 667.8 μmol/gr, 607.8 μmol/gr, and 573.8 340.48 and 309.8 μmol/gr, respectively&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1694</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitri Santy Budiarso1, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Andy Howard Limengan&lt;sup&gt;3&lt;/sup&gt;, Ratika Rahmasari&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;National Research and Innovation Agency, University of Pancasila, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Ubaya University, Raya Rungkut, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bannan Muthi'atul Af-idah</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Alpha Glucosidase Inhibitor Screening of Merremia peltata L. as Potential Traditional Treatment for Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Merremia peltata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">902-908</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Merremia peltata&lt;/em&gt; is ethnomedicine plant used as traditional medicine in Sulawesi, Sumatra, Maluku and Papua. &lt;em&gt;M. peltata&lt;/em&gt; is used for diabetic. Diabetes mellitus therapy with inhibit activity of alpha glucosidase enzyme could delay absorption of monosaccharides after a meal and interrupt glucose transport into the circulation. &lt;strong&gt;Objective: &lt;/strong&gt;This research purpose is to investigate in vitro antioxidant activity and alpha glucosidase enzyme inhibitor leaves and stem extract of &lt;em&gt;M. peltata.&lt;/em&gt; Method: The Stem and leaves of &lt;em&gt;M. peltata &lt;/em&gt;were extracted sequentially using the UAE method using hexane, ethyl acetate, and methanol as mobile phase/solvent. The &lt;em&gt;M. peltata &lt;/em&gt;extracts were subjected to the antioxidant activity assay by the DPPH radical scavenging and FRAP method. Antidiabetic activity was determined by an enzymatic alpha glucosidase inhibitor. &lt;strong&gt;Result:&lt;/strong&gt; The extract which had best performance in antioxidant activity was stem ME with value of IC&lt;sub&gt;50 &lt;/sub&gt;in DPPH 47.41 μg/mL and total antioxidant power 340.04 μmol/g. This study showed that leaves and stem extract of M .peltata have potential alpha glucosidase inhibitors for diabetic therapy. Stem ME had the best activity with IC&lt;sub&gt;50 &lt;/sub&gt;value 47.44 μg/mL, almost two times better than acarbose as a positive control (IC&lt;sub&gt;50&lt;/sub&gt; = 98.38 μg/mL). Leaves ME, leaves EA, and stem EA also give better activity of alpha glucosidase inhibitors than acarbose with IC&lt;sub&gt;50 &lt;/sub&gt;value 67.24 μg/mL, 69.38 μg/mL, and 72.85 μg/mL, respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;&lt;em&gt;M. peltata &lt;/em&gt;has potential antioxidant and alpha glucosidase inhibitor activity for diabetic therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">902</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bannan Muthi'atul Af-idah&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Institute of Sciences and Faculty of Pharmacy, University of Pancasila, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andreas Susilo Adi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Cytotoxic Bioassay on Blumeodendron toxbrai (Blume.) Stem Bark Hexane, Dichloromethane, and Methanolic Ekstract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticytotoxic DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Blumeodendron toksbraii</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">139-141</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Blumeodendron toksbrai&lt;/em&gt;i has the potential to be anti-HIV and anti α-glucosidase. &lt;strong&gt;Objective:&lt;/strong&gt; This research was conducted to examine the effects of antioxidant and cytotoxicity&lt;em&gt; in vitro &lt;/em&gt;from these compounds from methanolic stem bark extract. Method: Stem bark to be extracted with maceration using hexane, dichloromethane, and methanol solution. Extracts were quantified with respect to&lt;em&gt; in vitro&lt;/em&gt; antioxidant activity using the 2.2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging. Anticytotoxic activity was determined by cytotoxicity assay using MCF-7 cell line with Alamar Blue method.&lt;strong&gt; Results:&lt;/strong&gt; The observed IC&lt;sub&gt;50&lt;/sub&gt; value from hexane, dichloromethane, and methanol extract for antioxidant assay were 88.33 ± 0.19 μg/ mL, 74,54 ± 0,61 μg /mL and 94.1 ± 0.19 μg/mL respectively. IC&lt;sub&gt;50&lt;/sub&gt; value of anti-cytotoxic assay from hexane extract, dichloromethane and methanol extract is 121.24 ± 0.15 μg/mL, 55 ± 0,48 μg/mL and 70.71 ± 0.15 μg/mL. Conclusion: dichloromethane extract showed good promising result for anti-oxidant and cytotoxic assay, futher study needed to isolate compound from this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">139</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Andreas Susilo Adi&lt;sup&gt;1&lt;/sup&gt;,*, Berna Elya&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hanafi, M.Sc&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Depok 16424 West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK Serpong, Tangerang Selatan, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo- Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hepatoprotective Activity of Ethanol Extract of Annona cherimola Mill. On Paracetamol-Induced Liver Toxicity in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Paracetamol</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">874-882</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Annona cherimola&lt;/em&gt; Mill. (&lt;em&gt;A. cherimola&lt;/em&gt;) is mainly characterized by its antioxidant and cytoprotective properties due to their content of phenolic compounds. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate antioxidant and hepatoprotective activity of ethanol extract of leaves from &lt;em&gt;A. cherimola &lt;/em&gt;against induced toxicity by paracetamol in rats. &lt;strong&gt;Methods&lt;/strong&gt;: Amount of total phenolics compounds of ethanol extract of &lt;em&gt;A. cherimola &lt;/em&gt;Mill. was determined by the Folin-Ciocalteu method and antioxidant activity was evaluated by DPPH method. Three doses of the ethanol extract of leaves of &lt;em&gt;A. cherimola&lt;/em&gt; (250, 500 and 750 mg/Kg/day) were administered to rats and it was evaluated biochemical blood parameters: aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were measured, liver tissue was removed for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract of leaves from&lt;em&gt; A. cherimola &lt;/em&gt;had 41.26 mg GAE/g extract and antioxidant DPPH Scavenging Activity had 85.51%.&lt;em&gt; A. cherimola &lt;/em&gt;reduced blood levels of ALT, AST and ALP, compared to control group Paracetamol, ethanol extract, being more effective at doses of 750 mg/Kg/day. Histopathological evaluation suggested that &lt;em&gt;A. cherimola&lt;/em&gt; decreased hepatic necrosis and degenerative process induced by paracetamol. &lt;strong&gt;Conclusions: &lt;/strong&gt;Hepatoprotective activity of ethanol extract of leaves of&lt;em&gt; A. cherimola&lt;/em&gt; was demonstrated, being hepatoprotective activity dose dependent and the mechanism may involve antioxidant activity and total polyphenols found in extract of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">874</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;3&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Fisiología, Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Candra Irawan</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Application of Ultrasound-Assisted Extraction on the Stem Bark of Rhinachantus Nasutus (L.) Kurz, Total Phenolic, and Its Potential as Antioxidant and Inhibitor of Alpha-Glucosidase Enzyme Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase enzyme</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhinachantus nasutus (L.) Kurz</style></keyword><keyword><style  face="normal" font="default" size="100%">Total phenolics content</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasound-assisted extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1297-1303</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aims: &lt;/strong&gt;This study aims to obtain a stem bark extract of &lt;em&gt;Rhinachantus nasutus&lt;/em&gt; (L.) Kurz through the application of ultrasound-assisted extraction (UAE) and reveal: the total phenolic content in the extract; The extract's potential as an antioxidant with copper-reducing strength parameters, and its potential as an antidiabetic by inhibiting alpha-glucosidase activity. &lt;strong&gt;Results:&lt;/strong&gt; The crude ethanol extract of R. nasutus stem bark obtained from the UAE process was 7.4896 g with a yield of 4.99%. The high total phenolic content, namely 677.3343±0.0007 mg GAE / g sample, the antioxidant activity test using the CUPRAC method gave an IC&lt;sub&gt;50 &lt;/sub&gt;value of 18.43±0.20 mg / L. In addition, the ethanol extract of stem bark has a high ability to inhibit the activity of the alpha-glucosidase enzyme with an IC&lt;sub&gt;50&lt;/sub&gt; value of 10.95±0.28 mg / L. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of the stem bark of R. nasutus from UAE has the potential as a source of antioxidants and antidiabetic.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Candra Irawan&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;3&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Analytical Chemistry; Politeknik AKA Bogor; Bogor 16154; INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong (LIPI Indonesia), INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Heba I Elkhouly</style></author><author><style face="normal" font="default" size="100%">Ahmed A Hamed</style></author><author><style face="normal" font="default" size="100%">Asmaa M El Hosainy</style></author><author><style face="normal" font="default" size="100%">Mosad A Ghareeb</style></author><author><style face="normal" font="default" size="100%">Nagwa M Sidkey</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bioactive Secondary Metabolite from Endophytic Aspergillus Tubenginses ASH4 Isolated from Hyoscyamus muticus: Antimicrobial, Antibiofilm, Antioxidant and Anticancer Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aspergillus tubenginses</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive secondary metabolite</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyoscyamus muticus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">434-442</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Endophytes are the richest sources of natural compounds, showing biological varieties and pharmacological activities. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to isolate bioactive secondary metabolites from endophytic &lt;em&gt;Aspergillus tubenginses &lt;/em&gt;with study the biological activity of the isolated bioactive compounds. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Anofinic acid were obtained from &lt;em&gt;Aspergillus tubenginses &lt;/em&gt;crude extract using chromatographic techniques and characterized by spectral analysis. &lt;strong&gt;Results: &lt;/strong&gt;Nine endophytic fungi were isolated from Hyoscyamus muticus plant. The most efficient isolate was AF3 identified as &lt;em&gt;Aspergillus tubenginses&lt;/em&gt; ASH4 by 18S rRNA gene sequencing. Anofinic acid is an isolated active metabolite biosynthesized by A. tubenginsis was extracted from ethyl acetate with UPAC name of 2,2-dimethyl-2H-1-benzopyran-6-carboxylic acid. It shows a strong antimicrobial activity against human pathogenic bacteria such as &lt;em&gt;Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans&lt;/em&gt; and&lt;em&gt; Bacillus subtilis&lt;/em&gt;. Moreover, anofinic acid inhibits biofilm formation and has antioxidant activity, with strong activity against some carcinoma cells such as HCT-116, Hep-G2 and MCF-7. &lt;strong&gt;Conclusion:&lt;/strong&gt; Anofinic acid was purified from the endophytic &lt;em&gt;Aspergillus tubenginses&lt;/em&gt; crude extract and showed antimicrobial, antibiofilm, antioxidant, anticancer activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">434</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Heba I. Elkhouly&lt;sup&gt;1&lt;/sup&gt;, Ahmed A. Hamed&lt;sup&gt;2,&lt;/sup&gt;*, Asmaa M. El Hosainy&lt;sup&gt;1&lt;/sup&gt;, Mosad A. Ghareeb&lt;sup&gt;3&lt;/sup&gt;, Nagwa M. Sidkey&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Botany &amp;amp; Microbiology Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, NRC, Dokki-Giza, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornaish El-Nile, Imbaba, Giza, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Emy Koestanti Sabdoningrum</style></author><author><style face="normal" font="default" size="100%">Sri Hidanah</style></author><author><style face="normal" font="default" size="100%">Sri Chusniati</style></author><author><style face="normal" font="default" size="100%">Soeharsono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization and Phytochemical Screening of Meniran (Phyllanthus niruri Linn) Extract's Nanoparticles Used Ball Mill Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biological production</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical compound</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1568-1572</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study was to study the characterization and phytochemical screening of meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; linn) extract's nanoparticles used ball mill method. The effect of herbal products would be maximized, a formulation that able to increase solubility, stability, bioavailability, and a targeted system was needed so the use of simplicia would be more effective. One of alternative solutions to this problem was to make the preparation of meniran extract in the form of nanoparticles. Nanoparticles made it easier for extract to be absorbed in blood plasma and were more effective in achieving the target drug itself. The manufacture of meniran nanoparticles used ball mill method. Then, meniran extract nanoparticles characterization and phytochemical screening were carried out. Meniran (&lt;em&gt;Phyllanthus niruri&lt;/em&gt; Linn) extract nanoparticle characterization consisted of size, used Particle Size Analyzer (PSA), and morphology, used Scaning Electron Microscope (SEM). Phytochemical screening of meniran extract nanoparticles used qualitative screening by reagent test. The results showed that the meniran extract nanoparticles produced an average size of 192.6 nm. The averange shape of particle was imperfectly amorphous and the dominant composition was Carbon (C). Phytochemical screening showed the content of flavonoids, tannins, saponins, terpenoids and alkaloids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1568</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Emy Koestanti Sabdoningrum&lt;sup&gt;*&lt;/sup&gt;, Sri Hidanah, Sri Chusniati, Soeharsono&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bayyinatul Muchtaromah</style></author><author><style face="normal" font="default" size="100%">Didik Wahyudi</style></author><author><style face="normal" font="default" size="100%">Mujahidin Ahmad</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Rahmi Annisa</style></author><author><style face="normal" font="default" size="100%">Lil Hanifah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chitosan-Tripolyphosphate Nanoparticles of Mango Ginger (Curcuma mangga) Extract: Phytochemical Screening, Formulation, Characterization, and Antioxidant Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chemical identification</style></keyword><keyword><style  face="normal" font="default" size="100%">Chitosan</style></keyword><keyword><style  face="normal" font="default" size="100%">Mango ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">TPP</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1065-1071</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Mango ginger (&lt;em&gt;Curcuma mangga&lt;/em&gt;) is one of Indonesia's medicinal plants widely used in most communities as a lust booster and for detoxifying purposes. Therefore, the purpose of this study is to synthesize chitosan-tripolyphosphate nanoparticles from mango ginger extract, determine their chemical contents, the nano chitosan characteristics, and its antioxidant activity. &lt;strong&gt;Methods:&lt;/strong&gt; In this study, we macerated mango ginger using 70% ethanol solvent, then performed phytochemical test and formulation of chitosan nanoparticles of mango ginger extract. The group of secondary metabolites that showed positive results with the reagent test was further identified through TLC. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that the extract contained flavonoids and triterpenoids. Also, characterization of chitosan nanoparticles from the extract was conducted with FTIR test, PSA, XRD, and SEM. Based on the results, the nano chitosan particle size was 993 nm and examination with FTIR showed the presence of N-H and P=O groups, indicating ammonium ion interaction from chitosan with the polyanion from TPP and Mango ginger. Additionally, the XRD results showed that the crystals formed were in an amorphous form, which was supported by particle morphology images from SEM. Furthermore, the nanoparticles showed very strong antioxidant activity based on the reaction with DPPH. &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on these results, the phytochemical identification of mango ginger extract showed positive results in flavonoid and triterpenoid compounds. In addition, based on the characterization of the nanoparticles, the mango ginger extract showed positive results, illustrating that the nano chitosan synthesis was successful. Furthermore, the nano chitosan has a very strong antioxidant activity with an IC50 value of 18.08 μg/mL.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1065</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bayyinatul Muchtaromah&lt;sup&gt;1,&lt;/sup&gt;*, Didik Wahyudi&lt;sup&gt;1&lt;/sup&gt;, Mujahidin Ahmad&lt;sup&gt;1&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;2&lt;/sup&gt;, Rahmi Annisa&lt;sup&gt;3&lt;/sup&gt;, Lil Hanifah&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Maulana Malik Ibrahim State Islamic University, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medical and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Soumia KEDDARI</style></author><author><style face="normal" font="default" size="100%">Mokhtaria Yasmina BOUFADI</style></author><author><style face="normal" font="default" size="100%">Meriem MOKHTAR</style></author><author><style face="normal" font="default" size="100%">Djahira HAMED</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Culture of Lactic Acid Bacteria in Natural Environments Based on Dates</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dates</style></keyword><keyword><style  face="normal" font="default" size="100%">Fermentation</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactic acid bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Medium</style></keyword><keyword><style  face="normal" font="default" size="100%">MRS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">675-681</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Lactic acid bacteria are used in the food industry and have restrictive criteria for probiotic potential. The most common growth media used for lactic acid bacteria is de Man, Rogosa, and Sharpe culture medium (MRS). &lt;strong&gt;Methods: &lt;/strong&gt;In this study, three culture media were developed (date powder DP, date core DC and date core associated with lentils CL) based on locally available plant materials with a low market value to obtain a less expensive culture medium compared to the reference medium MRS for the growth of lactic acid bacteria. Four lactic strains were used (&lt;em&gt;Lactobacillus acidophilus&lt;/em&gt; LbA-CECT4529, &lt;em&gt;Lactobacillus plantarum &lt;/em&gt;LbP-CECT 748, &lt;em&gt;Bifidobacterium animalis &lt;/em&gt;subsp lactis Bb12 and &lt;em&gt;Bifidobacterium bifidum &lt;/em&gt;Bb 443). The growth and acidification kinetics of the tested strains were evaluated. The content sugar was determinate with HPLC.&lt;strong&gt; Results: &lt;/strong&gt;All lactic bacteria were able to grow on all culture media, but the best results were obtained with MRS and DP media. No significant difference (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05) was observed between DP and MRS medium. The consumption of sugars and proteins in the DP medium was good with all tested bacteria (70.87 to 81.96% and 71.42 to 80.90%, respectively). After the analysis of sugar content of DP medium before and after fermentation with high-performance liquid chromatography (HPLC), fructose was the only sugar detected (45.28μg/ml ± 0.24). After fermentation, 83% of fructose was consumed by Bb12. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present data allow us to conclude that date medium promotes the growth of lactic bacteria and can be considered as MRS standard medium substitute.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">675</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Soumia KEDDARI&lt;sup&gt;1,&lt;/sup&gt;*, Mokhtaria Yasmina BOUFADI&lt;sup&gt;1&lt;/sup&gt;, Meriem MOKHTAR&lt;sup&gt;1&lt;/sup&gt;, Djahira HAMED&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Beneficial Microorganisms, Functional Foodand Health (LMBAFS), Faculty of Natural Sciences and Life. Abdelhamid Ibn Badis University, Mostaganem, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Hanifa Nurul Fitri</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of Bintangor Leaf (Calophyllum soulattri Burm.f) on T47D Breast Cancer Cell Line (Cytotoxicity Study with MTT Assay Method)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bintangor Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast Cancer Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Calophyllum soulattri Burm.f</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">362-367</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The public has used Bintangor leaf (&lt;em&gt;Calophyllum soulattr&lt;/em&gt;i Burm.f) for various medical treatments, including treated inflamed eyes and gout. Aim: This research aimed to determine the cytotoxic effect of ethanol extract and fraction of &lt;em&gt;Calophyllum soulattri &lt;/em&gt;Burm. f leaf toward T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. &lt;strong&gt;Methods:&lt;/strong&gt; The test used T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells, the 3-4,5-dimethylthiazol-2yl -2,5-diphenyltetrazolium bromide (MTT) test method, and ELISA Reader to determine the absorbance. This method's principle was the presence of tetrazolium salts by the reductase system in the mitochondria of living cells formed purple formazan crystals. The used parameter was the value of IC&lt;sub&gt;50&lt;/sub&gt;.&lt;strong&gt; Results:&lt;/strong&gt; The result showed that ethanol extract, n-hexane fraction, ethyl acetate fraction, and butanol fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. The values of IC&lt;sub&gt;50&lt;/sub&gt; respectively are 585.31 μg/ml; 409.33 μg/ ml; 534.08 μg/ml; and 563.22 μg/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol extract and &lt;em&gt;Calophyllum soulattri&lt;/em&gt; Burm.f leaf fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Fatma Sri Wahyuni, Hanifa Nurul Fitri, Elsa Badriyya&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suryati</style></author><author><style face="normal" font="default" size="100%">Dira Hefni</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Cytotoxicity Study of Lantana camara Linn Essential Oil on HeLa Cancer Cells Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrodistillation</style></keyword><keyword><style  face="normal" font="default" size="100%">Lantana camara</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1498-1501</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Lantana camara &lt;/em&gt;Linn (Verbenaceae) is a natural plant that thrives in tropical climates and is relatively easy to cultivate. In Indonesia, this plant is still often considered as a weed. When held, the unpleasant smell and sticky hand make people dislike this plant even though the flowers are diverse. The essential oil was extracted from the leaves of &lt;em&gt;L. camara&lt;/em&gt; by hydrodistillation. This study aimed to see how cytotoxic&lt;em&gt; L. camara &lt;/em&gt;essential oil was against HeLa carcinoma cells. This research aimed to discover if &lt;em&gt;L. camara&lt;/em&gt; essential oil was cytotoxic to HeLa cancer cells. The GC-MS investigation of an essential oil recognized ten compounds; two main constituents of the oil were Caryophyllene (27.65%) and Germacrene D (23.01%). The essential oil showed cytotoxicity on HeLa cervical cancer cell lines. The cytotoxic effect of oil was determined using MTT, IC&lt;sub&gt;50&lt;/sub&gt; values were 44.86 μg/mL + 0.07&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1498</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suryati&lt;sup&gt;1&lt;/sup&gt;,*, Dira Hefni&lt;sup&gt;2&lt;/sup&gt;, Fatma Sri Wahyuni&lt;sup&gt;2&lt;/sup&gt;, Dachriyanus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Universitas Andalas, Kampus Limau Manis, Padang, West Sumatra 25163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Andalas, Kampus Limau Manis, Padang, West Sumatra 25163, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Cristel M. Ortiz-Noriega</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Anabel D. González- Siccha</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Patricia Contreras- Vera</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Gel Based on Ipomoea batatas (Purple Sweet Potato) on Dermal Wound Healing in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1720-1726</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. (I. batatas) is a root native from South America that is characterized by its antioxidant, antimicrobial and anti-inflammatory properties. These properties contribute to the wound healing process. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of a gel based on&lt;em&gt; I. batatas&lt;/em&gt; on dermal wound healing in mice.&lt;strong&gt; Material and methods: &lt;/strong&gt;An acid ethanolic extract (1.5 N hydrochloric acid: Ethanol 96 ° 15:85, v / v) was prepared with the peels of the roots of &lt;em&gt;I. batatas&lt;/em&gt; &quot;purple sweet potato&quot;, which was incorporated into the formulations 0.5% and 1% gel. Mus musculus Balb / c with induced injury were distributed in four experimental groups: Group I (Control), which did not receive any treatment. Group II (Gel base), Group III (Gel&lt;em&gt; I. batatas&lt;/em&gt; 0.5%) and Group IV (Gel &lt;em&gt;I. batatas&lt;/em&gt; 1%) received the daily administration of topical treatments for 14 days. Wound closure was determined during the experimentation time, then they were euthanized with sodium pentobarbital 60 mg / kg / pc v.ip. to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Group IV shows a higher percentage of wound closure, which is also evidenced in histopathological changes. &lt;strong&gt;Conclusions:&lt;/strong&gt; The 1% gel based on the ethanolic extract of the peels of the roots of &lt;em&gt;Ipomoea batatas &lt;/em&gt;(L.) Lam. they show healing activity in wounds induced in mice, being the most effective treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1720</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;,*, Cristel M. Ortiz-Noriega&lt;sup&gt;1&lt;/sup&gt;, Víctor E. Villarreal- La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;2&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario- Chávarri&lt;sup&gt;2&lt;/sup&gt;, Patricia Contreras-Vera&lt;sup&gt;4&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 4Hospital Víctor Lazarte Echegaray, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Pholawat Tingpej</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author><author><style face="normal" font="default" size="100%">Thanes Fuangfoo</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aporosa villosa Stem Ethanolic Extract on Adipogenesis in 3T3-L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aporosa villosa; Adipogenesis; Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1422-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: An excessive fat accumulation is related to development of obesity. Obesity is associated with the induction of insulin resistance and diabetes mellitus conditions. &lt;em&gt;Aporosa villosa &lt;/em&gt;is a plant that found in the Northern and Northeastern region of Thailand.&lt;strong&gt; Objective: &lt;/strong&gt;The present study used 3T3-L1 adipocytes for investigating the effect of &lt;em&gt;Aporosa villosa&lt;/em&gt; stem ethanolic extract (AS) on adipogenesis. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: 3T3-L1 adipocytes were used for measuring the cytotoxicity of AS at a concentration range of 3-100 μg/mL. After adipocyte cells treated with AS (3-100 μg/mL) for 8 days, the lipid accumulation was detected by Oil Red O staining and adipogenic gene expression were determined by quantitative real-time PCR. &lt;strong&gt;Results: &lt;/strong&gt;AS extracts (3-100 μg/mL) did not show cytotoxicity on cell proliferation. After 8 days of treating 3T3-L1 adipocytes with AS at doses of 3, 10, 30 and 100 μg/mL, the lipid droplets were reduced as compared to non-treated cells. Furthermore, the adipogenic genes were measured. The regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferatoractivated receptor γ (PPARγ) and sterol regulatory element binding protein 1c (SREBP1c) were found decreasing in AS extracts. The downstream target genes of these regulators cluster of differentiation (CD) 36, fatty acid synthase (FAS) and lipoprotein lipase (LPL) were also reduced by AS treatments. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings indicate that AS extract has an inhibitory activity on adipogenesis in 3T3-L1 adipocytes via suppressing C/EBPα, PPARγ and SREBP1c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Pholawat Tingpej&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3&lt;/sup&gt;, Thanes Fuangfoo&lt;sup&gt;4 &lt;/sup&gt;&amp;nbsp;Jarinyaporn Naowaboot&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Luqyana Putri</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Ethanol Extract of Moringa Leaf (Moringa oleifera Lam) Against the Activity and Capacity of Phagocytosis of Macrofag Cells and the Percentage of Leukosit Cells of White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">macrophage cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera Lam</style></keyword><keyword><style  face="normal" font="default" size="100%">Phagocytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">706-712</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study aims to determine the activity, capacity of macrophage phagocytosis, and percentage of leukocyte cells of male mice treated with the ethanol extract of moringa leaves (&lt;em&gt;Moringa oleifera&lt;/em&gt; Lam).&lt;strong&gt; Methods: &lt;/strong&gt;Twenty male mice were divided into four equal groups. The extract was administered orally for seven days at a dose of 10; 30; 100 mg/kg; and 0.5% CMC Na suspension as a negative control. On the 8&lt;sup&gt;th&lt;/sup&gt; day, the percentage of blood cell leukocytes in mice tail was calculated using a microscope. Suspension of &lt;em&gt;Staphylococcus aureus &lt;/em&gt;was injected intraperitoneally. The peritoneal fluid was taken to figure the activity and capacity of macrophage cell phagocytosis. The activity and capacity of macrophage cells are calculated using a microscope. The data were statistically analyzed by the one-way variance analysis (ANOVA) method and Duncan test.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that giving oral ethanol extract of Moringa leaves on male could increase macrophage activity and capacity, increasing dose, macrophage activity number, and capacity increased. The highest activity and capacity was achieved at a dose of 100 mg/kg. Moringa leaf extract can also increase the percentage of banded neutrophil, lymphocytes, eosinophil cells and decrease the percentage of neutrophil cell segments and monocytes from male white mice. The highest percentage of banded neutrophil, lymphocytes, eosinophils, and reductions in the percentage of neutrophil cell segments, monocytes present at doses of 100 mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;From the result, it can conclude that ethaol extract of Moringa Leaf can increase the activity and capacity of macrophages and percentage of neutrophils.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">706</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Elsa Badriyya, Luqyana Putri, Yufri Aldi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Fitri Rachmaini</style></author><author><style face="normal" font="default" size="100%">Dian Ayu Juwita</style></author><author><style face="normal" font="default" size="100%">Rini Haryati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Giving Red-fleshed Watermelon Juice (Citrullus lanatus (Thunb.)) on Pregnant White Mice (Mus Musculus) Exposed by Monosodium Glutamate (MSG) Orally on the Number and Morphology of Fetus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Lycopene</style></keyword><keyword><style  face="normal" font="default" size="100%">Monosodium glutamate</style></keyword><keyword><style  face="normal" font="default" size="100%">Red-fleshed watermelon</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">97-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Infertility can occur due to the presence of free radicals. One of the most popular of free radical is monosodium glutamate. Free radicals from monosodium glutamate can be prevented by antioxidant compounds. Red-fleshed-fleshed watermelon is a fruit that contains antioxidant compound such as lycopene. &lt;strong&gt;Aim: &lt;/strong&gt;This research was conducted to see the effect of red-fleshed-fleshed watermelon juice on the fetus including number, morphology, visual abnormalities and body weight of pregnant white mice exposed to monosodium glutamate solution orally. Total of 25 female white mice aged around 2-3 months were used as test animals. &lt;strong&gt;Methods: &lt;/strong&gt;Pregnant white mice were divided into 5 test groups. Group I and II served as negative controls (whithout treatment) and positive controls (exposed to monosodium glutamate solution orally at dose of 1g/kgBW). Group III was given a solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 1.4 g/kgBW. Group IV was given solution of monosodium glutamate orally at dose of 1 g/KgBW added red-fleshed-fleshed watermelon juice at dose of 4.2 g/kgBW. The research data were processed using the one-way ANNOVA test. &lt;strong&gt;Results: &lt;/strong&gt;The result showed that mice body weight, fetal number and morphology (body weight, body length, tail length, and head diameter) did not significantly influence (p&amp;gt;0.05). However, it significantly affected the weight gain of mice during pregnancy. However, it significantly affected the weight gain of mice during pregnancy day 6 to day 17 of pregnancy (p&amp;lt;0.05) and found abnormalities in the fetus such as low birth weight (LBW) and haemorrhage in group II and III. &lt;strong&gt;Conclusion:&lt;/strong&gt; It can be concluded that watermelon juice at dose of 2.8 g/kgBW and 4.2 g/kgBW are effective in ward offfree radicals from monosodium glutamate orally at dose of 1 g/kgBW.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">97</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwisari Dillasamola, Fitri Rachmaini*, Dian Ayu Juwita, Rini Haryati &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faradila Amirabagya</style></author><author><style face="normal" font="default" size="100%">Rr Ayu Fitri Hapsari</style></author><author><style face="normal" font="default" size="100%">Endah Wulandari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Jatropha curcas L Seed Extract on AST/ALT Activity and The Central Vein Thickness in Liver</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AST/ALT</style></keyword><keyword><style  face="normal" font="default" size="100%">Jatropha</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">The central vein thickness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">66-72</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Jatropha is known as anti-inflammatory, antioxidant, anti-fungal, anti-cancer, and has coagulant activity. &lt;em&gt;Jatropha curcas&lt;/em&gt; (&lt;em&gt;Jatropha curcas&lt;/em&gt; L.) contains toxic compounds such as cursin, ricin and gallic acid. The liver has an important role in the process of metabolism and detoxification of xenobiotic substances. Repeated exposure to toxic compounds can damage hepatic hepatocytes. If the hepatocyte cells are injured, the AST/ALT enzyme is excreted and goes into the blood vessels, as an indicator of liver damage. This is also indicated by changes in the thickness of the central veins. This study aims to determine the effect of giving jatropha seed extract (&lt;em&gt;Jatropha curcas &lt;/em&gt;L.) on AST/ALT activity and the central vein thickness in the liver. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The research design was experimental, using male rats (&lt;em&gt;Rattus novergicus&lt;/em&gt; L) Sprague Dawley strain. The rats were given Jatropha seed extract at doses of 0, 5, 25, 50, and 250 mg/ KgBW for 28 days. To assess liver damage, measurements of AST/ ALT activity and thickness of the central vein in the liver were performed.&lt;strong&gt; Results:&lt;/strong&gt;&lt;em&gt; &lt;/em&gt;Jatropha&lt;em&gt; &lt;/em&gt;seed extract increased ALT activity at doses of 25.50, and 250 mg / KgBW compared to the control group (1.207; 1.62; 1.548 IU/L/ mg tissue x 10&lt;sup&gt;-3&lt;/sup&gt;); and increased AST activity at doses of 5, 25, 50, and 250 mg / KgBW compared to the control group (0.769; 0.974; 1.449; 1.185 IU/L/ mg tissue x 10&lt;sup&gt;-3&lt;/sup&gt;); Central vein thickness increased at doses of 25 and 50 mg/KgBW (6.17 and 4.9 μm) (Kruskal Wallis; p&amp;gt; 0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Jatropha curcas&lt;/em&gt; L. seed extract increased the activity of AST/ALT and the thickness of the central vein in the liver.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">66</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faradila Amirabagya&lt;sup&gt;1&lt;/sup&gt;, Rr Ayu Fitri Hapsari&lt;sup&gt;2&lt;/sup&gt;, Endah Wulandari&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Students Faculty of Medicine and Biology Molecular, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Histology, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, State Islmic University Syarif Hidayatullah, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Baiqi Nur Hairi</style></author><author><style face="normal" font="default" size="100%">Nadar Sukri Lubis</style></author><author><style face="normal" font="default" size="100%">Tri Wahyuni Lestari</style></author><author><style face="normal" font="default" size="100%">Putri Reno Intan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Sambiloto and Spirulina Combination on Mucin-1 Protein Expression in Medial Colon of Plasmodium berghei ANKA Infected Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Medial colon</style></keyword><keyword><style  face="normal" font="default" size="100%">Muc-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei Anka</style></keyword><keyword><style  face="normal" font="default" size="100%">Sambiloto</style></keyword><keyword><style  face="normal" font="default" size="100%">Spirulina</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1359-1365</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Malaria still be health problem in the world, especially in Eastern Indonesia. Malaria’s inflammation and metabolism defect can cause colonic damage, such as enhancement Muc-1 protein expression and goblet cells hyperplasia. Sambiloto and spirulina combination as antiinflammatory and antioxidative agent can prevent medial colon damage &lt;em&gt;Plasmodium berghei &lt;/em&gt;ANKA infected mice. The aim of the study to show the effect of sambiloto and spirulina combination on Muc-1 protein activity in medial colon &lt;em&gt;Plasmodium berghei&lt;/em&gt; ANKA infected mice. This study use preserve male Swiss Webser mice colonic tissue which has inoculated by&lt;em&gt; Plasmodium berghei &lt;/em&gt;ANKA, whose treatment group include positive control (dehyroartemisin piperaquine), negative control (carboxymethil cellulose), AP (sambiloto), AP+ES (sambiloto+spirulina extract), and AP+PS (sambiloto+spirulina powder) and terminated after 28 days of treatment. Colonic tissue was stained with immunohistochemistry and observed using light microscope (400x) in five different field and was analyzed with ImageJ® sowtware, and statisitcal analysis was done with SPSS 20.0. According to One Way ANOVA and Duncan posthoc test, only AP+PS(120,98 ±3,37), which significantly difference between negative control, AP, and AP+ES group. Meanwhile, between DHP, AP+PS group not significantly differenece. Sambiloto extract and spirulina powder combination can reduce Muc-1 protein expression in medial colon &lt;em&gt;Plasmodium berghei &lt;/em&gt;ANKA infected mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1359</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1-4&lt;/sup&gt;,*, Baiqi Nur Hairi&lt;sup&gt;5&lt;/sup&gt;, Nadar Sukri Lubis&lt;sup&gt;6&lt;/sup&gt;, Tri Wahyuni Lestari&lt;sup&gt;7&lt;/sup&gt;, Putri Reno Intan&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mouchira Abdel Salam</style></author><author><style face="normal" font="default" size="100%">Hala M. Raslan</style></author><author><style face="normal" font="default" size="100%">Doha A. Mohamed</style></author><author><style face="normal" font="default" size="100%">Aliaa Elgendy</style></author><author><style face="normal" font="default" size="100%">Rehab A. Hussein</style></author><author><style face="normal" font="default" size="100%">Omneya Moguib</style></author><author><style face="normal" font="default" size="100%">Maha Abdelhadi</style></author><author><style face="normal" font="default" size="100%">Rokia Abd El-Shafy Soliman El-Banna</style></author><author><style face="normal" font="default" size="100%">Karem Fouda</style></author><author><style face="normal" font="default" size="100%">Safenaz Y. El Sherity</style></author><author><style face="normal" font="default" size="100%">Emad N. Zikri</style></author><author><style face="normal" font="default" size="100%">Nagwa M. Ammar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone health</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone mineral density</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypocholesterolemic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">688-697</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Great concern has been raised recently concerning the therapeutic impact of soybean. The present study aims to investigate the effects of soybean on bone health and metabolic parameters in postmenopausal women. &lt;strong&gt;Methods:&lt;/strong&gt; In this clinical study, 72 healthy postmenopausal women aged between 45-65 years were given soybean bioactive fraction 2 capsules (500mg each) daily for 24 weeks. Each capsule contained 31.25 mg proteins, 3.2 mg carbohydrates and 4.84 mg isoflavones. Blood pressure, bone mineral density, plasma osteocalcin (OCN), telopeptides of collagen type I (CTX), fasting insulin and blood glucose, lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and TSH were assessed prior and after the period of the study. Insulin resistance was calculated by homeostatic model assessment-IR formula (HOMA-IR). &lt;strong&gt;Results:&lt;/strong&gt; Soy ingestion resulted in a significant increase in T score of the hip and OCN; recording -1.97±0.13/-1.76±0.12 and 22.44±0.60ng/ml/30.93±0.57ng/ml before/after treatment, respectively. A marked decrease was also detected in CTX from 2.22±0.10ng/ml to 1.48±0.08ng/ml. With regard to metabolic parameters, there was a significant decrease in fasting insulin (5.40±0.62uU/ml vs 4.15±0.45uU/ ml), however, fasting glucose and HOMA-IR showed no significant alterations. Lipid profile displayed remarkable decline in total cholesterol (188.86±7.23mg/dl vs 159.60±4.72mg/dl, triglycerides (97.09±5.23mg/dl vs 83.56±4.27mg/dl), LDL-c (75.60±3.06mg/dl vs 63.95±1.86mg/ dl) accompanied with a significant elevation in HDL-c (53.09±0.88 vs 65.81mg/dl±0.80mg/ dl). A significant decrease in both TSH (1.97±0.13 uIU/ml vs 1.40±0.08 uIU/ml) and serum creatinine (0.82±0.02mg/dl vs0.77±0.02mg/dl) was also noticed. &lt;strong&gt;Conclusion:&lt;/strong&gt; Consumption of soy improves bone health, reduces cardiovascular risk with no adverse effects on kidney, liver or thyroid functions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mouchira Abdel Salam&lt;sup&gt;1&lt;/sup&gt;, Hala M. Raslan&lt;sup&gt;2&lt;/sup&gt;, Doha A. Mohamed&lt;sup&gt;3&lt;/sup&gt;, Aliaa Elgendy&lt;sup&gt;1&lt;/sup&gt;, Rehab A. Hussein&lt;sup&gt;4,&lt;/sup&gt;*, Omneya Moguib&lt;sup&gt;2&lt;/sup&gt;, Maha Abdelhadi&lt;sup&gt;2&lt;/sup&gt;, Rokia Abd El- Shafy Soliman El-Banna&lt;sup&gt;5&lt;/sup&gt;, Karem Fouda&lt;sup&gt;3&lt;/sup&gt;, Safenaz Y. El Sherity&lt;sup&gt;5&lt;/sup&gt;, Emad N. Zikri&lt;sup&gt;1&lt;/sup&gt;, Nagwa M. Ammar&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Complementary Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Internal Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmacognosy Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biological Anthropology Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Resta Angelia</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract Activity of Pegagan Embun (Hydrocotyle sibthorpioides L.) Against Hematopoietic on Anemic Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract of Hydrocotyle sibthorpioides L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Reticulocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">866-873</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) is known to have many benefits, including as a blood booster. This study aims to determine the activity of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) on the formation of red blood cells. The parameters include the number of erythrocytes, reticulocytes, hemoglobin levels, and hematocrit values in anemic male white mice induced by chloramphenicol 130 mg/kg for 14 days. &lt;strong&gt;Methods:&lt;/strong&gt; Anemic mice consisted of 4 groups, namely the first group was given physiological NaCl, the second, third, and fourth groups were given ethanol extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) at a dose of 10, 50 and 100 mg/kgper oral every day, for 14 days. Observations were made on days 0, 14, 21, and 28. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that administration of pegagan embun extracts at a dose of 10, 50, and 100 mg/kgto anemic male white mice significantly increase the number of erythrocyte cells, the number of reticulocytes, the hemoglobin levels, and the hematocrit values (p &amp;lt;0.05). Increasing the dose and duration of pegagan embun extract administration could provide a more significant increase in the hematopoietic parameters (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt;It can be concluded that the extract of pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; L.) can be used to treat anemia in male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">866</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Dwisari Dillasamola, Elsa Badriyya, Resta Angelia, Yufri Aldi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thanh Ha Tuan Nguyen</style></author><author><style face="normal" font="default" size="100%">Ngan Nguyen Hoang</style></author><author><style face="normal" font="default" size="100%">Xuan Thanh Nguyen</style></author><author><style face="normal" font="default" size="100%">Binh Nhu Do</style></author><author><style face="normal" font="default" size="100%">Son Trinh The</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluate the Effect of Herbal Extract Remedy for Treatment of Liver Cirrhosis in in-vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CCl4</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cirrhosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Silymarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">XGTQ herbal extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">189-195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the in-vitro effect of herbal extract recepies, namely XGTQ, in the treatment of liver cirrhosis that induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet in rats. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Liver cirrhosis was induced by subcutaneously injecting CC14 (initial dose of 5,0ml/kg, followed by 1,2ml/kg twice a week in 10 weeks) in winstar rats. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered a day with fresh water and water mixed with 30% ethanol in another day. The rats were randomly divided into 5 groups and given distilled water (group 1 or control group and group 2 or cirrhosis group), silymarin (group 3 or reference group) or the herbal recipes, aka XGTQ, drug extract (group 4, 5) for 4 weeks. Blood was collected for biochemical test and livers were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.&lt;strong&gt; Results: &lt;/strong&gt;In cirrhotic wistar rats, the XGTQ herbal drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the level of enzymes AST, ALT in the blood (p&amp;lt;0.01), increasing plasma albumin and decreasing prothrobin time (p&amp;lt;0.05); improving physical condition, macroscopic and microscopic images of H&amp;amp;E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effect of herbal recipes XGTQ increased dramatically with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. &lt;strong&gt;Conclusion: &lt;/strong&gt;The aqueous extract of XGTQ herbal remedy has have a good effect in treatment of liver cirrhosis in in-vitro and to be equivalent to that of silymarin at the dose of 70 mg/kg.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">189</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Thanh Ha Tuan Nguyen&lt;sup&gt;1,2,#&lt;/sup&gt;, Ngan Nguyen Hoang&lt;sup&gt;1,#&lt;/sup&gt;, Xuan Thanh Nguyen&lt;sup&gt;1,2&lt;/sup&gt;, Binh Nhu Do&lt;sup&gt;1,2&lt;/sup&gt;, Son Trinh The&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Vietnam Military Medical University, No.160 Phung Hung st, Phuc La, Ha dong, Ha noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Military Hospital 103, No.261 Phung Hung st, Phuc La, Ha Dong, Ha Noi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;#&lt;/sup&gt;These authors contributed equally to this work and are co‐first authors&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Maribel Herrera-Ruiz</style></author><author><style face="normal" font="default" size="100%">María del Carmen Gutiérrez</style></author><author><style face="normal" font="default" size="100%">Vera Petricevich</style></author><author><style face="normal" font="default" size="100%">María Angélica Santana</style></author><author><style face="normal" font="default" size="100%">Martha Navarro</style></author><author><style face="normal" font="default" size="100%">Angélica Berenice Aguilar-Guadarrama</style></author><author><style face="normal" font="default" size="100%">Gabriel Navarrete-Vázquez</style></author><author><style face="normal" font="default" size="100%">Irene Perea-Arango</style></author><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of the Anticonvulsant, Anxiolytic, Sedative, and Neuroprotective Activities of Polysaccharides from Mycelium of Two Ganoderma Species</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">a- and b-glucan</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">GABA</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtissi</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma sp</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1161-1173</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ganoderma lucidum&lt;/em&gt; has been used as a medicinal mushroom since centuries in East Asia. Recent reports have shown that metabolites isolated from &lt;em&gt;Ganoderma&lt;/em&gt; species have shown effects on central nervous system. &lt;strong&gt;Objective:&amp;nbsp;&lt;/strong&gt;To determine the neuroprotective, anticonvulsant, anxiolytic, and sedative effects of &lt;em&gt;Ganoderma &lt;/em&gt;sp. and &lt;em&gt;Ganoderma curtisii&lt;/em&gt; polysaccharides. &lt;strong&gt;Methods:&lt;/strong&gt; Polysaccharides (Gsp-PS2 or Gc-PS2) were isolated from two &lt;em&gt;Ganoderma mycelia&lt;/em&gt; submerged cultures. Acute toxicity effects of Gc-PS2 or Gsp-PS2 on mice were treated orally with doses of 50 - 2000 mg/kg. Anticonvulsant activity was determined using three chemoconvulsants: kainic acid (KA), strychnine, or pentylenetetrazole (PTZ). Anxiolytic-like effects were determined using the elevated plus maze test on mice. GABA release evoked by GC-PS2 or Gsp-PS2 content was determined by HPLC. Neuroprotective effects of Gsp-PS2 or Gc-PS2 were determined by glial activation, histopathological changes, and immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; Gc-PS2 or Gsp-PS2 showed neuroprotective activity by diminishing neuronal death, reducing glial activation and Neu-N expression levels. Gsp-PS2 or Gc-PS2 inhibited convulsions in the KA model. An anxiolytic-like, but not a sedative effect was reported in mice treated with Gc-PS2 or Gsp-PS2. Polysaccharides Gc-PS2 or Gsp-PS2 evoked endogenous GABA release and increased its concentration within the incubation medium. Pretreatment with Gsp-PS2 or Gc-PS2 showed a reduction of the LPSinduced NO production. Gc-PS2 or Gsp-PS2 did not produce toxic effects. &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;&lt;em&gt;Ganoderma &lt;/em&gt;sp. or &lt;em&gt;Ganoderma curtisii &lt;/em&gt;polysaccharides showed neuroprotective and anticonvulsant activities in animal models. The anticonvulsant activity may involve the GABAergic neurotransmision.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1161</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Verónica Núñez-Urquiza,&lt;sup&gt;1&lt;/sup&gt; Juana Villeda- Hernández,&lt;sup&gt;2&lt;/sup&gt; Elizur Montiel-Arcos,&lt;sup&gt;3&lt;/sup&gt; Isaac Tello,&lt;sup&gt;3&lt;/sup&gt; Victoria Campos-Peña,&lt;sup&gt;2&lt;/sup&gt; Maribel Herrera-Ruiz,&lt;sup&gt;4&lt;/sup&gt; María del Carmen Gutiérrez,&lt;sup&gt;5&lt;/sup&gt; Vera Petricevich,&lt;sup&gt;6&lt;/sup&gt; María Angélica Santana,&lt;sup&gt;7&lt;/sup&gt; Martha Navarro,&lt;sup&gt;2&lt;/sup&gt; Angélica Berenice Aguilar-Guadarrama,&lt;sup&gt;1&lt;/sup&gt; Gabriel Navarrete-Vázquez,&lt;sup&gt;8&lt;/sup&gt; Irene Perea- Arango,&lt;sup&gt;5&lt;/sup&gt; Ismael León-Rivera&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina 1, Col. Centro, Xochitepec, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Centro de Investigación en Biotecnología, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Medicina, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Centro de Investigación en Dinámica Celular, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, Estados Unidos Mexicanos.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Asmaa Sayed Abd Elkarim</style></author><author><style face="normal" font="default" size="100%">Amal H. Ahmed</style></author><author><style face="normal" font="default" size="100%">Abdelbaset M. Elgamal</style></author><author><style face="normal" font="default" size="100%">Radwan El Haggar</style></author><author><style face="normal" font="default" size="100%">Alaa Khedr</style></author><author><style face="normal" font="default" size="100%">Mohamed Fouad Shalaby</style></author><author><style face="normal" font="default" size="100%">Roula Bayram</style></author><author><style face="normal" font="default" size="100%">Samah Shabana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixtures</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Herb-herb interaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal Plants.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1366-1376</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This work aims to find a new treatment based on the development of safe natural anti-diabetic mixtures. It assesses the hypoglycemic activity of natural mixtures and determines whether there are any negative side effects from the interaction of the herbs and the herbs. &lt;strong&gt;Methods:&lt;/strong&gt; Six natural mixtures were tested for anti-diabetic activity, which was confirmed by a pathological histological examination. We performed a GC-MS analysis on active mixtures 1 and 2, yielding 54 and 38 compounds, respectively. The major compounds were Gingerol, Butan-2-one and 4-(3-hydroxy-2-methoxyphenyl) (97 and 64.02 per cent). &lt;strong&gt;Results: &lt;/strong&gt;Among the six samples, the organic extract of mixture 1 and 2 showed a significant reduction in BGL compared to the standard drug glimepiride at a dose of 10 mg/kg ip and demonstrated a beneficial effect on renal function in alloxan-induced diabetic mice. These results were confirmed by a histopathological study which revealed that both mixture 1 and mixture 2 had decreased morphological and ultrastructural changes in the triggered liver. Docking of cuminaldehyde, Gingerol and α-Copaenin at the active site of human pancreatic enzymes α-amylase and aldol reductase revealed that these compounds had binding affinity at the active site of the enzymes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Our results revealed the anti-diabetic activity of non-polar mixtures consisting of long chain hydrocarbons, oils and non-polar components, thus suggesting that the herbal formulation is safe and effective for the treatment and complication of type 2 diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1366</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Asmaa Sayed Abd Elkarim&lt;sup&gt;1,*&lt;/sup&gt;, Amal H. Ahmed&lt;sup&gt;2,&lt;/sup&gt; Abdelbaset M. Elgamal&lt;sup&gt;3&lt;/sup&gt;, Radwan El Haggar&lt;sup&gt;4&lt;/sup&gt;, Alaa Khedr&lt;sup&gt;5&lt;/sup&gt;, Mohamed Fouad Shalaby&lt;sup&gt;5&lt;/sup&gt;, Roula Bayram&lt;sup&gt;5&lt;/sup&gt;, Samah Shabana&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouthst. (former EL Tahrirst.)- Dokki-Giza, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, Al-azhar University, 11884 Nasr City, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki- Giza-EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo 11795, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacognosy, Faculty of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, MUST, 6th October City, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelhak Chergui</style></author><author><style face="normal" font="default" size="100%">Latifa El Hafid</style></author><author><style face="normal" font="default" size="100%">El Amine Ajal</style></author><author><style face="normal" font="default" size="100%">Imane Zakariya</style></author><author><style face="normal" font="default" size="100%">Rachid Nejjari</style></author><author><style face="normal" font="default" size="100%">Mohammed Reda Tazi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evolution of Biometric Parameters and Oil Fatty Acid Composition of Argan &quot;Argania spinosa L. Skeels&quot; Fruits from Beni- Snassen (Eastern Region of Morocco) During Ripening</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Argan fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Beni-Snassen</style></keyword><keyword><style  face="normal" font="default" size="100%">Biometeric parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Fatty Acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Ripeness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">296-308</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Argania spinosa&lt;/em&gt; Skeels is an endemic forest essence of Morocco. The argan of the north-east of Morocco remains a virgin subject of study without enough value given to it. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study is to asses the evolution of biometric parameters and fatty acids composition of the argan fruits from Beni-Snassen region during ripening. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;4 fruit shapes harvested over seven months were characterized through the measurement of their biometric parameters (size and weight), and their composition of majority fatty acids. &lt;strong&gt;Results: &lt;/strong&gt;the studied argan tree could be classified into two major groups, namely: early-riped trees with oval or oval-apiculate fruits and late-riped trees with fusiform or spherical fruits. When considering the fruits size and weight, the highest values were recorded on late-ripened fruits, more particularly fusiform shapes. The obtained results showed, on one hand, a significant difference in the unsaturated fatty acids, according to the fruit ripeness stage and shapes, being the later significantly affecting the stearic acid content; and on another hand, it was noted an increase of oleic acid content while linoleic acid decreased. In the maturation stage, the spherical shaped fruits were found to have the highest ratio of unsaturated/saturated fatty acids.&lt;strong&gt; Conclusion:&lt;/strong&gt; The results demonstrated the possibility to predict the kernel’s weight from the fruit’s length. The results also showed the good dietary and nutritional quality of spherical shapes and that the biometric parameters are important criteria for the differentiation of argan tree fruits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdelhak Chergui&lt;sup&gt;1,&lt;/sup&gt;*, Latifa El Hafid&lt;sup&gt;2&lt;/sup&gt;, El Amine Ajal&lt;sup&gt;1&lt;/sup&gt;, Imane Zakariya&lt;sup&gt;1&lt;/sup&gt;, Rachid Nejjari&lt;sup&gt;1&lt;/sup&gt;, Mohammed Reda Tazi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Mohammed V University, Faculty of Medicine and Pharmacy, Av. Mohammed Belarabi El Alaoui, BP 6203- Rabat institut-Rabat, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Improving Agricultural Productivity, Biotechnology &amp;amp; Environment, Mohammed I University, Faculty of Science, Blvd. Mohammed VI, BP 717-Oujda, MOROCCO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Regional Center of professions of Education and Training of the Orient- Oujda, MOROCCO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Huynh Tan Hoi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Few Potential Treatments of Asthma in Vietnam</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asthma</style></keyword><keyword><style  face="normal" font="default" size="100%">Health</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Patient</style></keyword><keyword><style  face="normal" font="default" size="100%">Prevention</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">640-643</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Asthma is a chronic condition that can be fatal if it isn't treated promptly during an attack. Patients with an asthma attack cannot breathe enough air to supply the body with oxygen and within minutes, the patient can die. In Vietnam today, people can buy antibiotics on their own without the need of a doctor to prescribe or visit. Many people who only see signs of coughing, wheezing have voluntarily bought antibiotics for use. The overuse of antibiotics is very common in asthma patients. In fact, antibiotics are not effective in most types of asthma. Abuse of antibiotics is not only ineffective, but also makes the patient more tired, reduces resistance, and digestive disorders. Some antibiotics can even lead to acute asthma attacks. This article covers some of the remedies that can eradicate asthma with a combination of several fairly safe treatments. Through analysis of the scientific composition and current studies, it is possible to treat asthma and maintain good health.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">640</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Huynh Tan Hoi&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department, FPT University, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Joko Kuncoroningrat Susilo</style></author><author><style face="normal" font="default" size="100%">Dwi Winarni</style></author><author><style face="normal" font="default" size="100%">Saikhu Akhmad Husen</style></author><author><style face="normal" font="default" size="100%">Suhailah Hayaza</style></author><author><style face="normal" font="default" size="100%">Sri Puji Astuti Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Ruey-An Doong</style></author><author><style face="normal" font="default" size="100%">Win Darmanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Ganoderma applanatum Crude Polysaccharides on Carbon Tetrachloride-Induced Early Liver Fibrosis in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Crude polysaccharides</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma applanatum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1428-1436</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Liver fibrosis is a treatable disease when still at early stages. &lt;em&gt;Ganoderma applanatum &lt;/em&gt;plays role as alternative medicine. The fungi have antioxidant, anti-inflammatory, and anticancer bioactivities. This study aimed to evaluate the hepatoprotective effects of &lt;em&gt;G. applanatum &lt;/em&gt;crude polysaccharides (GACP) on liver fibrosis due to CCl4 induction. &lt;strong&gt;Methods&lt;/strong&gt;: This study was divided into six groups. BALB/c mice were given CCl4 dissolved in olive oil (2 mL/kg; 1:3) intraperitoneally (i.p) twice a week for four weeks to produce a liver fibrosis model. Distilled water (control group), silymarin 100 mg/kg and GACP 25, 50, 100 mg/kg were given once daily for four weeks. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis-α (TNF-α) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA) kit. Histopathology was stained by hematoxylin &amp;amp; eosin (H&amp;amp;E) and Masson’s trichome.&lt;strong&gt; Results: &lt;/strong&gt;The administration of GACP effectively prevented ALT, AST, TNF-α, and IL-6 levels from high elevation. Additionally, the GACP had protective effect after liver histological analysis exhibited less injury in the liver tissue.&lt;strong&gt; Conclusion: &lt;/strong&gt;The hepatoprotective effect of GACP on liver fibrosis is mainly due to avoid high elevation of pro-inflammatory cytokine. This result revealed that GACP could be a potential hepatoprotective agent for later clinical therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1428</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raden Joko Kuncoroningrat Susilo&lt;sup&gt;1&lt;/sup&gt;, Dwi Winarni&lt;sup&gt;1,*&lt;/sup&gt;, Saikhu Akhmad Husen&lt;sup&gt;1&lt;/sup&gt;, Suhailah Hayaza&lt;sup&gt;1&lt;/sup&gt;, Sri Puji Astuti Wahyuningsih&lt;sup&gt;1&lt;/sup&gt;, Ruey-An Doong&lt;sup&gt;1,2&lt;/sup&gt;, Win Darmanto&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Analytical and Environmental Sciences, National Tsing Hua University, Sec. 2 Kuang Fu Road, Hsinchu 30013, TAIWAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Afdhila Fitri</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.) With Carbon Clearance Method Towards Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbon clearance</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunostimulants</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Neutrophil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1472-1477</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;L.) has been used traditionally to cure various diseases such as anti-inflammatory, neutralizing toxins, dysentery, and others. This study aims to determine the immunostimulant effect of pegagan embun herbs extract using the carbon clearance method, the number, and the percentage of leukocyte cells. In this study, 25 male white mice were used, which were divided into five groups, groups 1, 2, and 3 given pegagan embun herbs extract in a dose of 10 mg/kgbw; 50 mg/ kgbw; 200 mg/kgbw, group 4 was given 0,5% Na CMC, and group 5 were given stimuno 50 mg/kgbw. The preparation is given orally for seven consecutive days. On the eighth day, the phagocytosis index, number, and percentage of leukocyte cells were determined. The results showed that pegagan embun herbs extract has immunostimulant activity. The phagocytosis index of the 10 mg/kgbw dose group is 1.0211, 1.27796 for the 50 mg/kgbw, and 1.5250 for the 200 mg/kgbw. Then, the number of leukocytes of the 10, 500, and 200 mg/kgbw are 8.820/μL, 9.906/μL, and 10.790/μL, respectively. The percentage of lymphocyte cells are 58,5%, 60,6% and 62,8%, and for segment neutrophil cells were 26%, 27,6% and 30% for group 10, 50, and 200 mg/kgbw extract. Based on the results, that the pegagan embun herbs extract has immunostimulant activity against male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1472</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Afriwardi&lt;sup&gt;1&lt;/sup&gt;,*, Afdhila Fitri&lt;sup&gt;2&lt;/sup&gt;, Elidahanum Husni&lt;sup&gt;2&lt;/sup&gt;, Elsa Badriyya&lt;sup&gt;2&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nolitha Nkobole</style></author><author><style face="normal" font="default" size="100%">Olusola Bodede</style></author><author><style face="normal" font="default" size="100%">Ahmed A Hussein</style></author><author><style face="normal" font="default" size="100%">Gerhard Prinsloo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro α-Glucosidase and α-Amylase Activities of Wild and Cultivated Amaranthus spp. and Isolated Compounds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">α-Amylase; α-glucosidase; Blood glucose; Diabetes mellitus; Hyperglycemia; Phytochemicals.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1614-1620</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Diabetes mellitus is a serious metabolic disorder that affects many South Africans. There is urgent need for alternative and affordable diabetic therapy from edible wild plants which have been used by the indigenous people for many years. This study presents in vitro antidiabetic effects of methanol leaf extracts of wild and cultivated Amaranthus spp. and isolated compounds. &lt;strong&gt;Methods:&lt;/strong&gt; The inhibitory effects against yeast α-glucosidase and porcine α-amylase were determined using a dilution series of ethanolic extracts of wild and cultivated leaf extracts and isolated compounds of Amaranthus spp. The aerial parts of the plant material were subjected to silica gel chromatography to yield three compounds. &lt;strong&gt;Results:&lt;/strong&gt; Wild A. hybridus showed potent α-glucosidase enzyme activity (89.92±0.04%) at the lowest concentration tested (0.125 mg/mL) in comparison to acarbose which exhibited 80.20±0.13% inhibition at the same concentration. Cultivated A. cruentus extracts inhibited α-glucosidase enzyme activity (84.95 ± 0.04%) at the lowest concentration compared to cultivated A. hybridus which exhibited inhibitory activities of 72.28 ± 0.06%. In addition, three compounds namely, α-spinasterol, palmitic acid and pheophorbide A-methyl ester isolated from wild A.cruentus were tested for in vitro antidiabetic activity. Palmitic acid demonstrated the highest inhibition against α-glucosidase for all the concentrations tested. Tested separately, the isolated compounds were weaker α-amylase enzyme inhibitors however, when the compounds were combined, inhibition of α-amylase increased to 58.49± 002% at 0.5 mg/mL. &lt;strong&gt;Conclusions:&lt;/strong&gt; Extracts and compounds of Amaranthus showed strong α-glucosidase activity inhibition and mild α-amylase activity inhibition suggesting that the extracts and compounds slow glucose absorption.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1614</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nolitha Nkobole&lt;sup&gt;1&lt;/sup&gt;,*, Olusola Bodede&lt;sup&gt;1&lt;/sup&gt;, Ahmed A Hussein&lt;sup&gt;2&lt;/sup&gt;, Gerhard Prinsloo&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Agriculture and Animal Health, University of South Africa, Science campus, Florida, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Cape Peninsular University of Technology, Symphony Way, Bellville, Western Cape, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Numlil Khaira Rusdi</style></author><author><style face="normal" font="default" size="100%">Erni Hernawati Purwaningsih</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Vivo Antimammary Tumor Effects of Soybean Extract with Targeted Lunasin (ET-Lun)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">EGFR</style></keyword><keyword><style  face="normal" font="default" size="100%">HER2</style></keyword><keyword><style  face="normal" font="default" size="100%">In-vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1269-1276</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background/Objective: &lt;/strong&gt;Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. &lt;strong&gt;Results: &lt;/strong&gt;The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). &lt;strong&gt;Conclusions: &lt;/strong&gt;These results indicated that the ET-Lun has anti-breast cancer activit&lt;em&gt;y in vivo.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1269</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Numlil Khaira Rusdi&lt;sup&gt;1,2&lt;/sup&gt;, Erni Hernawati Purwaningsih&lt;sup&gt;3,7&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;4&lt;/sup&gt;, Berna Elya&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;6-8,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA. '&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sesilia Rante Pakadang</style></author><author><style face="normal" font="default" size="100%">Maria Hilaria</style></author><author><style face="normal" font="default" size="100%">Sisilia Teresia Rosmala Dewi</style></author><author><style face="normal" font="default" size="100%">Santi Sinala</style></author><author><style face="normal" font="default" size="100%">Jumain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">MIC and MKC Analysis of Herbal Medicine in Indonesia Against Mycobacterium tuberculosis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antituberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">MIC</style></keyword><keyword><style  face="normal" font="default" size="100%">MKC</style></keyword><keyword><style  face="normal" font="default" size="100%">Plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Potential</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1058-1064</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Data shows that the success of the Directly Observed Treatment Shortcourse program(DOTS) in South Sulawesi Province was 74.8%. Causes of failure include standard drug side effects, length of treatment period and &lt;em&gt;Mycobacterium tuberculosis &lt;/em&gt;(M.tb) bacterial resistance. The development of new drugs today in addition to synthetic chemical drugs are also natural materials that have the potential as antituberculosis with various mechanisms. The aim of the research is to prove the potential of plants used by the community as tuberculosis drugs empirically based on phytochemical screening extracts, M.tb sensitivity to extracts and determine the MIC (Minimum Inhibitory Concentration) and MKC (Minimum Killing Concentration) values of M.tb. Selection of plant test materials based on survey results and Riskesdas data in 2015. Testing the potential of plant extracts based on the sensitivity of M.tb to the test material &lt;em&gt;in vitro&lt;/em&gt; with an incubation period of 7 weeks. Showed 25 plants that have been used empirically as tuberculosis drugs proved to be potential antibacterial M.tb. Phytochemical screening produces flavonoids and tannins in all extracts. Some extracts contain alkaloids, saponins and steroids. Potential tests show that the extract concentration that is effectively used as a tuberculosis drug is: Meniran leaves and miana 100 ppm. Banana peel and basil leaves 125 ppm. 150 ppm bangle rhizome. Turmeric rhizome 175 ppm. Roselle flowers, soursop leaves and lime 200 ppm. Sandalwood, bitter melon leaves and binahong 225 ppm, Curcuma rhizome, kencur, turmeric and onion tubers, gotu kola leaves, sea lava and papaya 275 ppm. Ginger rhizome, brotowali stem, noni leaf, cloves and mangosteen peel &amp;gt; 275 ppm. 90% garlic bulb extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1058</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sesilia Rante Pakadang&lt;sup&gt;1&lt;/sup&gt;, Maria Hilaria&lt;sup&gt;2&lt;/sup&gt;, Sisilia Teresia Rosmala Dewi&lt;sup&gt;1&lt;/sup&gt;, Santi Sinala&lt;sup&gt;1,&lt;/sup&gt;*, Jumain&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Health Polytechnic of the Makassar Ministry of Health, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Health Polytechnic of the Kupang Ministry of Health, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maryono</style></author><author><style face="normal" font="default" size="100%">Netti Herawati</style></author><author><style face="normal" font="default" size="100%">Meuthia Aulia Farhani Gaffar</style></author><author><style face="normal" font="default" size="100%">Sartini</style></author><author><style face="normal" font="default" size="100%">Aliyah</style></author><author><style face="normal" font="default" size="100%">Elly Wahyudin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microwave-Assisted Extraction and Identification of γ- Oryzanol from Rice Bran (Oryza sativa L. cv Ciliwung)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Microwave assisted extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice Bran (Oryza sativa L. cv Cilliwung)</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolite</style></keyword><keyword><style  face="normal" font="default" size="100%">γ- Oryzanol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1242-1247</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Rice Bran (&lt;em&gt;Oryza sativa&lt;/em&gt; L. cv Cilliwung) is a by-product of the rice milling process, consisting of an outer layer of rice grains with the whole seed institute. Rice bran oil is a result of rice bran extraction. Rice bran oil contains antioxidant compounds, one of which is oryzanol, so this study aims to determine the levels of or-oryzanol in rice bran. The stages of the research included sample preparation, extraction using Microwave-Assisted Extraction (MAE), followed by Vacuum Liquid Column Chromatography (VLCC) was extracted using the MAE method produced 30 mL of black-brown rice bran oil extract. A total of 8 grams of rice bran extract was obtained at VLCC using eluent (n-hexane: ethyl acetate) with ratios 9:1, 7:3, and 1:1, respectively. Then the five factions obtained were characterized using HPLC, and GC/MS identified the mass of the γ-oryzanol compound.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1242</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maryono&lt;sup&gt;1,&lt;/sup&gt;*, Netti Herawati&lt;sup&gt;1&lt;/sup&gt;, Meuthia Aulia Farhani Gaffar&lt;sup&gt;1&lt;/sup&gt;, Sartini&lt;sup&gt;2&lt;/sup&gt;, Aliyah&lt;sup&gt;2&lt;/sup&gt;, Elly Wahyudin&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Makassar State University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rani Wardani Hakim</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Tri Juli Edi Tarigan</style></author><author><style face="normal" font="default" size="100%">Sri Widia A Jusman</style></author><author><style face="normal" font="default" size="100%">Erni H Purwaningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Study of Acalypha indica to Leptin, Alpha Glucosidase, and its Antihyperglycemic Effect on Alpha Glucosidase</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acalypha indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha glucosidase.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiobesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1639-1647</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The purpose of this study is to find potential inhibitors of leptin as a proinflammatory adipokine and alpha glucosidase as an enzyme that mediate hyperglycaemia; to alter the chronic complications of obesity from herbal Acalypha indica (Ai). This study was conducted using in silico molecular docking to evaluate the Ai compounds interaction with leptin and alpha glucosidase. The in vitro assay to alpha glucosidase was done to explore antihyperglycemic effect of Ai, as hyperglycaemia is the key process of chronic complication of obesity. &lt;strong&gt;Material and&lt;/strong&gt; &lt;strong&gt;Methods: &lt;/strong&gt;Protein target were leptin and alpha glucosidase; compounds from Ai plant were repundusinic, mauritanin, hesperetin, acaindinin, and glucogalin in pdb format. Molecular docking using autodock vinna. In vitro assay of Ai antihyperglycemic activity was done to alpha glucosidase and was define as IC50 level. &lt;strong&gt;Result:&lt;/strong&gt; The results from the docking analysis demonstrated that compounds from Ai roots contain antihyperglycemic-antiobesity activity which acted by inhibiting leptin and alpha glucosidase receptors. Repundusininc and mauritanin compounds contain hydrogen bond with the greatest leptin enhancer activity on Ser9, Thr35, Glu8, Ser9, Thr25, Gln111, Lys211, Leu7 for repundisinic and Glu8, Thr25, Gly112 and Leu7 for mauritanin. Hesperetin, acaindinin and glucogallin were the most identical compounds with similar affinity binding value to alpha glucosidase. Ai roots was already proven as anti-hyperglycemic-antiobesity which was further confirmed by in vitro assay to alpha glucosidase (IC50 19,429 μg/ml.). &lt;strong&gt;Conclusion:&lt;/strong&gt; The results demonstrated that Ai have anti hyperglycaemic-antiobesity effects and was found to be potentially as antihyperglycemic by in vitro assay to alpha glucosidase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1639</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rani Wardani Hakim&lt;sup&gt;1,2,6&lt;/sup&gt;,*, Fadilah Fadilah&lt;sup&gt;3,6,7&lt;/sup&gt;, Tri Juli Edi Tarigan&lt;sup&gt;4&lt;/sup&gt;, Sri Widia A Jusman&lt;sup&gt;5&lt;/sup&gt;, Erni H Purwaningsih&lt;sup&gt;2,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Amaq Fadholly</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Yulanda Antonius</style></author><author><style face="normal" font="default" size="100%">Suhailah Hayaza</style></author><author><style face="normal" font="default" size="100%">Raden Joko Kuncoroningrat Susilo</style></author><author><style face="normal" font="default" size="100%">Bilqis Inayatillah</style></author><author><style face="normal" font="default" size="100%">Mada Triandala Sibero</style></author><author><style face="normal" font="default" size="100%">Sin War Naw</style></author><author><style face="normal" font="default" size="100%">Gabrielle Ann Villar Posa</style></author><author><style face="normal" font="default" size="100%">Teguh Hari Sucipto</style></author><author><style face="normal" font="default" size="100%">Soegen Soegijanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona squamosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiviral activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DENV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Vero cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">456-462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of &lt;em&gt;Annona squamosa&lt;/em&gt; leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). &lt;strong&gt;Methods: &lt;/strong&gt;In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo™ Assay. In addition, we used CellTiter-Glo&lt;sup&gt;®&lt;/sup&gt; Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. &lt;strong&gt;Results: &lt;/strong&gt;DENV-2 replication inhibited by ASLE in Vero cells with IC&lt;sub&gt;50&lt;/sub&gt; = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC&lt;sub&gt;50&lt;/sub&gt; for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for&lt;em&gt; in vivo&lt;/em&gt; assessment in the progress of a potent antiviral against DENV-2.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">456</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arif Nur Muhammad Ansori&lt;sup&gt;1&lt;/sup&gt;, Amaq Fadholly&lt;sup&gt;1&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;1&lt;/sup&gt;, Yulanda Antonius&lt;sup&gt;2,&lt;/sup&gt;*, Suhailah Hayaza&lt;sup&gt;3&lt;/sup&gt;, Raden Joko Kuncoroningrat Susilo&lt;sup&gt;3&lt;/sup&gt;, Bilqis Inayatillah&lt;sup&gt;4&lt;/sup&gt;, Mada Triandala Sibero&lt;sup&gt;5&lt;/sup&gt;, Sin War Naw&lt;sup&gt;6&lt;/sup&gt;, Gabrielle Ann Villar Posa&lt;sup&gt;7&lt;/sup&gt;, Teguh Hari Sucipto&lt;sup&gt;8,&lt;/sup&gt;*, Soegeng Soegijanto&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Doctoral Program in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Master Program in Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Myitkyina University, Myitkyina, MYANMAR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noha Abd Alkareem Younis Younis</style></author><author><style face="normal" font="default" size="100%">Rania Mohammad Hamam</style></author><author><style face="normal" font="default" size="100%">Amal Mayyas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Online Survey: Prevalence and Attitude of Jordanians Towards Using Herbal Remedies in the Pandemic COVID-19</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Botanicals.</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronavirus</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal immunomodulators</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal remedies</style></keyword><keyword><style  face="normal" font="default" size="100%">Pandemic</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1632-1638</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Coronavirus disease 2019 (COVID-19) is a new virus caused by SARS-CoV-2, a coronavirus from the coronavirus family, that can provoke severe respiratory syndrome. The disease became a pandemic in December 2019. Impaired immune modulation is one of the processes implicated in its pathogenesis, which contributes to poor COVID-19 outcomes. Many investigations have been conducted using medication to control coronaviral infections as antiviral agents or immunomodulators. The results of these tests, however, demonstrated that these medications were useless in fighting the disease. Some people believe that using herbal immunomodulators can aid in the prevention or even curing of COVID-19. Based on prior research, in the management of COVID-19, several botanicals may be useful. We go over the patient attitude and benefits of using such herbal remedies in the regimen of treating COVID-19 in Jordan.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1632</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Noha Abd Alkareem Younis Younis&lt;sup&gt;1&lt;/sup&gt;, Rania Mohammad Hamam&lt;sup&gt;2&lt;/sup&gt;,*, Amal Mayyas&lt;sup&gt;3&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Al Balqa Applied University, Aqaba Universal College, Aqaba, JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Princess Sarvath Community College, Amman, JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Health Sciences, American University of Madaba, Madaba, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Krittapat Phairoh</style></author><author><style face="normal" font="default" size="100%">Parichart Hongsing</style></author><author><style face="normal" font="default" size="100%">Chanida Palanuvej</style></author><author><style face="normal" font="default" size="100%">Nijsiri Ruangrungsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Specification and Rotenone Content in Derris elliptica Stems</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Quality evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC-densitometry</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC-image analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">124-132</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Derris elliptica &lt;/em&gt;(Wall.) Benth. (Leguminosae) is the tropical plant which has been used as natural poison as well as veterinary medicine due to its best-known phytochemical compound, rotenone to kill invertebrates and fish. However, there is no report on pharmacognostic specification and quantification of rotenone content from &lt;em&gt;D. elliptica&lt;/em&gt; stems. &lt;strong&gt;Objective: &lt;/strong&gt;This present study aimed to conduct the pharmacognostic parameters as well as to conduct the validated methods to quantify rotenone content in&lt;em&gt; D. elliptica&lt;/em&gt; stems following WHO guideline.&lt;strong&gt; Methods: &lt;/strong&gt;Dried &lt;em&gt;D. elliptica&lt;/em&gt; stems from 15 different areas in Thailand were examined for pharmacognostic secification. Their rotenone contents were quantitatively analyzed by TLC densitometry using winCATS software as well as TLC-image analysis using ImageJ free software. &lt;strong&gt;Results: &lt;/strong&gt;Macroscopic and microscopic characteristics, TLC fingerprint and physicochemical parameters were reported in this study. The water content, loss on drying, total ash content and acidinsoluble ash content were determined to be 8.81±1.30, 5.77 ±0.92, 7.35±0.63, 1.221±0.20%, respectively. The ethanol, and water-soluble extractive values were found to be 4.07±1.23 and 11.31±1.68%, respectively. Additionally, the validation method for quantification of rotenone content was developed. The contents of rotenone in &lt;em&gt;D. elliptica &lt;/em&gt;stem ethanolic extract evaluated by TLC-densitometry and TLC-image analysis were found to be 0.2870±0.1242 and 0.2844±0.1209% by dried weight, respectively. The result between these two analytical methods were shown no significant difference.&lt;strong&gt; Conclusion: &lt;/strong&gt;The validated methods were able to effectively quantify rotenone content in &lt;em&gt;D. elliptica&lt;/em&gt; stems from various locations in Thailand which could be used for the specification of this raw material with reference to its chemical marker. Thus, this study provides the necessary and adequate information for authentication and standardization of &lt;em&gt;D. elliptica &lt;/em&gt;stems.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">124</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Krittapat Phairoh&lt;sup&gt;1&lt;/sup&gt;, Parichart Hongsing&lt;sup&gt;2&lt;/sup&gt;, Chanida Palanuvej&lt;sup&gt;1&lt;/sup&gt; and Nijsiri Ruangrungsi&lt;sup&gt;1,3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Public Health Sciences Program, College of Public Health Sciences, Chulalongkorn University, Bangkok, 10330, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Integrative Medicine, Mae Fah Luang University, Chiangrai, 57100, THAILAND. 3College of Pharmacy, Rangsit University, Pathumthani, 12000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kolomiets Natalia Eduardovna</style></author><author><style face="normal" font="default" size="100%">Korolev Stepan Alexandrovich</style></author><author><style face="normal" font="default" size="100%">Isaykina Nadezhda Valentinovna</style></author><author><style face="normal" font="default" size="100%">Abramets Natalia Yurievna</style></author><author><style face="normal" font="default" size="100%">Kudryavtseva Darya Vladimirovna</style></author><author><style face="normal" font="default" size="100%">Boev Roman Sergeevich</style></author><author><style face="normal" font="default" size="100%">Zhalnina Ludmila Vladimirovna</style></author><author><style face="normal" font="default" size="100%">Ali Abdujalil Kaid Hasan</style></author><author><style face="normal" font="default" size="100%">Bondarchuk Ruslan Anatolevich</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Studies of the Leaves and Fructus of Arctium lappa L. (Asteraceae Bercht. &amp; J. Presl)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analitical standarts</style></keyword><keyword><style  face="normal" font="default" size="100%">Arctium lappa L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Fructus</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic standarts</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1734-1745</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The state quality assurance system ensures the confidence of consumers that the product meets its quality requirements. In this study, pharmacognostic standards of the leaves and fructus of burdock are specified for the first time. &lt;strong&gt;Methods: &lt;/strong&gt;Microscopic analysis was carried out by using the microscope Carl Zeiss. The UV spectrum were measured on an SF-2000 spectrophotometer. &lt;strong&gt;Results:&lt;/strong&gt; Macroscopically, the leaves are heart-shaped, broad-heart-ovate-shaped with a spaced emarginatedserrate or whole edge, with a wide, wedge-shaped, rounded, uneven base, acute apex, green on the outer surface, grayish slightly pubescent on the inner surface. The fructus are obovate or wedge-compressed, slightly curved, the color is brown/black with spots, or variegated with black spots on a gray background. The microscopic examination of the leaves revealed the presence of epidermis, large submerged and non-submerged stomata of the anomocytic type, 2 types of simple unbranched multi-cellular and glandular capitate trichomes; essential oil glands. Microscopic examination of the leaf petiole revealed the presence of 2 types of simple multi-cellular trichomes, epidermis, angular collenchyma, bicollateral bundles, parenchyma. The stomatal index value is 8.28±0.81 per 1cm2. The microscopy of the fructus revealed the presence of elongated cells of the pericarp epidermis; mesocarp; endocarp; endosperm with aleurone grains and drops of fatty oil. The qualitative phytochemical analysis of revealed the presence of polysaccharides, tannins, flavonoids, terpenoids, saponins, phenolic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; Physical and chemical parameters (moisture, extractive value, ash content) were also specified. These specific data are important for establishing diagnostic indicators for standardization, identification, preparation of new quality standards.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1734</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kolomiets Natalia Eduardovna&lt;sup&gt;1,2&lt;/sup&gt;,*, Korolev Stepan Alexandrovich&lt;sup&gt;1&lt;/sup&gt;, Isaykina Nadezhda Valentinovna&lt;sup&gt;1&lt;/sup&gt;, Abramets Natalia Yurievna&lt;sup&gt;1&lt;/sup&gt;, Kudryavtseva Darya Vladimirovna&lt;sup&gt;1&lt;/sup&gt;, Boev Roman Sergeevich&lt;sup&gt;3&lt;/sup&gt;, Zhalnina Ludmila Vladimirovna&lt;sup&gt;1&lt;/sup&gt;, Ali Abdujalil Kaid Hasan&lt;sup&gt;1&lt;/sup&gt;, Bondarchuk Ruslan Anatolevich&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Analysis, Siberian State Medical University, Tomsk, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Kemerovo State Medical University, Kemerovo, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;LLC «Visterra», Barnaul, RUSSIA. 4Office of the State Employment Service in the Kirov region, Kirov, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gouri Kumar Dash</style></author><author><style face="normal" font="default" size="100%">Mohd Haziq Bin Hashim</style></author><author><style face="normal" font="default" size="100%">Abdul Karim Russ Hassan</style></author><author><style face="normal" font="default" size="100%">Ravindran Muthukumarasamy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Studies on the Leaves of Annona muricata Linn</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Preliminary physiochemical screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">241-247</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Annona muricata&lt;/em&gt; Linn. (Family: Annonaceae) is a well-known traditional and natural medicine over the world; in Malaysia it serves as a treatment for many kinds of diseases. Studies have been reported that &lt;em&gt;A. muricata &lt;/em&gt;can be used to treat diseases due to its antibacterial, antiviral, antifungal, antitumor, anthelmintic, analgesic, hypotensive, antiinflammatory, and has immune enhancing properties. Despite having several medicinal functions and properties, however there is no standardization parameters have been reported in the literature for the leaves of&lt;em&gt; A. muricata&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;Therefore, through this research study, the macroscopical and microscopical characteristics, physicochemical parameters such as ash values, extractive values, fluorescence analysis and preliminary phytochemical analysis of the leaves were investigated.&lt;strong&gt; Results: &lt;/strong&gt;Based on the observation of the transverse section of the leaves, the presence of upper cuticle, upper epidermis, palisade cells, vascular bundle, spongy mesophyll, phloem fibers, lignified vessels, xylem vessels, collenchyma, lower epidermis, lower cuticle and parenchyma served as important key differentiating features for the studied plant. The powder microscopy revealed the presence of pieces of trichrome, collapsed uniseriate multicellular covering trichrome, spongy mesophyll, phloem fibres, xylem vessels, paracytic stomata and fragment of epidermis showing cell and palisade cell. Calcium oxalate crystals were also observed even though the captured image was slightly unclear. The phytochemical screening of the leaves was carried out using four different extracts which showed the presence of steroids, saponins, flavonoids, tannins carbohydrates and proteins, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; Based on this research finding, the pharmacognostic standardization of the plant can be established thus, providing ease in identifying and determining the purity and quality of the investigated plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">241</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gouri Kumar Dash&lt;sup&gt;1,2&lt;/sup&gt;, Mohd Haziq Bin Hashim&lt;sup&gt;1&lt;/sup&gt;, Abdul Karim Russ Hassan&lt;sup&gt;3&lt;/sup&gt;, Ravindran Muthukumarasamy&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Universiti Kuala Lumpur Royal College of Medicine Perak, Faculty of Pharmacy and Health Sciences, 30450 Ipoh, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, Odisha, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Universiti Kuala Lumpur Royal College of Medicine Perak, Faculty of Medicine, 30450 Ipoh, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author><author><style face="normal" font="default" size="100%">Rika Hartati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacological Activities and Phytochemical Compounds: Overview of Pouteria Genus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pharmacological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Pouteria genus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">577-584</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Species of Pouteria are widely spread in various countries. Pouteria is one of the genus that have diverse pharmacological activities. This review includes an overview of the species from Pouteria, phytochemical methods used in isolation of compounds from Pouteria, and their pharmacological activities. The trends in the pharmacological activity of Pouteria is antioxidant activity, antidiabetic and antimicrobial activities. However, information on its use as a traditional medicine from Pouteria was poor. Chemical compounds that have been widely isolated from Pouteria genus included phenolic acid, other phenolics non flavonoid, flavonoids, and terpenoids derivative. The most widely reported chemical compounds from Pouteria are terpenoid derivatives. Further research is needed for the mechanism of action based on the pharmacological activites of chemical compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sani Nurlaela Fitriansyah&lt;sup&gt;1,2,&lt;/sup&gt;*, Irda Fidrianny1, Rika Hartati&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung-40132, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biology, Indonesian School of Pharmacy (Sekolah Tinggi Farmasi Indonesia), Bandung-40226, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Dea Firdaus</style></author><author><style face="normal" font="default" size="100%">Nina Artanti</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Rosmalena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Constituents and In vitro Antidiabetic and Antioxidant Properties of Various Extracts of Kenikir (Cosmos caudatus) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">890-895</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (&lt;em&gt;Cosmos caudatus&lt;/em&gt;) &lt;em&gt;kenikir’s &lt;/em&gt;leaves. In previous studies, &lt;em&gt;kenikir's l&lt;/em&gt;eaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of &lt;em&gt;kenikir's&lt;/em&gt; leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various&lt;em&gt; kenikir’s &lt;/em&gt;leave extract. &lt;em&gt;Kenikir’s&lt;/em&gt; leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%. Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p&amp;lt;0.05) and antidiabetic (p&amp;lt;0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of &lt;em&gt;kenikir’s&lt;/em&gt; leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">890</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Dea Firdaus&lt;sup&gt;1&lt;/sup&gt;, Nina Artanti&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Rosmalena&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, South Tangerang, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mruthunjaya Kenganora</style></author><author><style face="normal" font="default" size="100%">Sushma Rudraswamy</style></author><author><style face="normal" font="default" size="100%">Jai Shankar Puttabuddi Hombarvalli</style></author><author><style face="normal" font="default" size="100%">Nagabhushana Doggalli</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemicals  A Novel Therapeutic Approach to Control Oral Biofilm</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dental plaque</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Microbial resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Oral biofilm</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Quorum sensing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">730-736</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Humans and micro-organisms have co-evolved having a synergetic relationship with their resident microbiome. The mouth features a diverse microbiota that grows on oral surfaces as functionally and structurally organized biofilms. The oral biofilms are accountable for causing a wide range of chronic diseases and owing to the development of antibiotic-resistant bacteria it has really become tough to treat with efficacy. Operative control of oral biofilm and the resulting infectious diseases epitomizes a significant universal challenge. For this kind of therapeutics, natural herbal products are perfect candidates because of their unique properties. The current review presents a novel approach to control and eradicate oral biofilm by the phytochemicals. Research on phytochemicals is zealously focused on health promotion, disease prevention, and also on the development of novel therapeutic interventions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">730</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mruthunjaya Kenganora&lt;sup&gt;1&lt;/sup&gt;, Sushma Rudraswamy&lt;sup&gt;2,&lt;/sup&gt;*, Jai Shankar Puttabuddi Hombarvalli&lt;sup&gt;3&lt;/sup&gt;, Nagabhushana Doggalli&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, J.S.S College of Pharmacy, Mysore, J.S.S Academy of Higher Education and Research, Mysore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Public Health Dentistry, J.S.S Dental College and Hospital, J.S.S Academy of Higher Education and Research, Mysore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Oral Medicine and Radiology, J.S.S Dental College and Hospital, J.S.S Academy of Higher Education and Research, Mysore, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Oral Medicine and Radiology, J.S.S Dental College and Hospital, J.S.S Academy of Higher Education and Research, Mysore, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amira Horchani</style></author><author><style face="normal" font="default" size="100%">Fadwa Chaabane</style></author><author><style face="normal" font="default" size="100%">Mahassen Barboura</style></author><author><style face="normal" font="default" size="100%">Imen Mokdad-Bzeouich</style></author><author><style face="normal" font="default" size="100%">Aimen Abbassi</style></author><author><style face="normal" font="default" size="100%">Amine Trabelsi</style></author><author><style face="normal" font="default" size="100%">Leila Chekir-Ghedira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry and Biological Evaluation of Daphne gnidium L. Butanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Daphne gnidium</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysosmal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide production.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1688-1693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Daphne gnidium &lt;/em&gt;L. (Thymelaeaceae) has been used in the Mediterranean basin to treat skin diseases, rheumatism and toothache.&amp;nbsp;&lt;strong&gt;Objective: &lt;/strong&gt;the aim of this study was to evaluate the biological activities of butanol extract from the &lt;em&gt;D. gnidium&lt;/em&gt; leaves. &lt;strong&gt;Methods: &lt;/strong&gt;A quantitative analysis by high‐performance liquid chromatography with a diode array detector (HPLC‐DAD) was performed. The antioxidant activities were evaluated by using three different assays: 2,2-diphenyl-l-picrylhydrazyl assay (DPPH assay), deoxyribose degradation assay and Cellular Antioxidant Activity (CAA) assay. The butanol extract was investigated for anti-inflammatory and analgesic activities in animal models. In addition, its effect on the production of NO and lysosomal activity &lt;em&gt;in vivo &lt;/em&gt;was assessed. &lt;strong&gt;Results: &lt;/strong&gt;The HPLC-DAD analysis showed the presence of daphnetin. The butanol extract had a remarkable antioxidant activity in the different systems tested. Furthermore, it has an anti-inflammatory effect by inhibiting the xyleneinduced ear edema and reduced the number of abdominal constrictions in mice indicating analgesic effect. It also was found to inhibit (NO) production and lysosomal activity &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings support the daphne use in traditional medicine for its analgesic and anti-inflammatory activities. Further investigations to elucidate its mechanism of action are required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amira Horchani&lt;sup&gt;1,&lt;/sup&gt;*, Fadwa Chaabane&lt;sup&gt;1&lt;/sup&gt;, Mahassen Barboura&lt;sup&gt;1&lt;/sup&gt;, Imen Mokdad-Bzeouich&lt;sup&gt;1&lt;/sup&gt;, Aimen Abbassi&lt;sup&gt;1&lt;/sup&gt;, Amine Trabelsi&lt;sup&gt;1&lt;/sup&gt;, Leila Chekir-Ghedira&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Unit of natural bioactive substances and biotechnology, Faculty of Pharmacy of Monastir, 5000, TUNISIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Cell and Molecular Biology, Faculty of Dental Medicine of Monastir,5000, TUNISA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Jorge L Campos-Reyna</style></author><author><style face="normal" font="default" size="100%">Víctor E Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">María V González Blas</style></author><author><style face="normal" font="default" size="100%">Cinthya L Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui- Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Julio H</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Activity of Medicinal Plants as Pain Modulators: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antinociceptive</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural product</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">248-263</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This review aims to demonstrate the relevance that medicinal plants and their promising results have in prevention and treatment of pain. The neurophysiological bases of pain have been analyzed and the potential mechanisms of action have been proposed, it has also been determined that the main experimental models used for the evaluation of the analgesic potential are: acetic acid-induced writhing test, formalin test, hot-plate test, capsaicin-induced nociception, cinnamaldehyde-induced nociception, glutamate-induced nociception, tail–flick test and tail immersion test. There are countless medicinal plants with potential analgesic activity, in some of them main responsible compounds for the activity are flavonoids (vitexin, quercetin, naringenin, astragalin, eupatilin), alkaloids (scotanamine B, bullatine A, S-(+)- dicentrine, stephalagine, lappaconitine), terpenoids (p-cymene, thymol, menthol, citronellol, myrcene, carvacrol, linalool) and saponins (siolmatroside I, cayaponoside D, cayaponoside B4, cayaponoside A1); however, all studies have only been carried out up to pre-clinical stages. Therefore, it is recommended to carry out kinetic studies of the most remarkable natural compounds, evaluate mixtures of active compounds for diminishing doses to avoide possible side effects, and continue with clinical studies of medicinal plants whose safety has already been reported.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">248</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,&lt;/sup&gt;*, Jorge L. Campos-Reyna&lt;sup&gt;2&lt;/sup&gt;, Víctor E Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, María V. González Blas&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;3&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, William Antonio Sagástegui- Guarniz&lt;sup&gt;1&lt;/sup&gt;, Luz M. Guerrero- Espino&lt;sup&gt;2&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ..&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Jorge L. Campos-Reyna</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Anabel D González-Siccha</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María V. González-Blas</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Neuroprotective Activity of Essential Oils in Memory and Learning Impairment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alzheimer disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Animal model</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurodegenerative diseases</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1312-1322</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Memory and learning is negatively affected by many factors. Alzheimer's disease is a progressive and irreversible neurological disorder that occurs gradually, a sickness that is increasingly common, and multiple scientific articles suggest that essential oils improve memory and learning and are useful in the treatment of various neurodegenerative diseases, including Alzheimer's disease. This review aims to conduct a critical collection of current information on research into both memory and learning impairment, as well as essential oils that are able to avoid this neurodegenerative disease. Currently, different animal models have been useful for the study of neurodegenerative problems that alter memory and learning, experimental pharmacological, genetic and toxicological models that can simulate specific cognitive deficit syndromes. In addition, research in this review show several essential oil compounds that present positive results in animal studies, but still lack human clinical trials. Therefore, the assessment of the safety and efficacy of these phytochemical compounds in diseases that cause memory impairment and learning, remain a promising area for future research.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review article</style></work-type><section><style face="normal" font="default" size="100%">1312</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carmen R. Silva-Correa&lt;sup&gt;1,&lt;/sup&gt;*, Jorge L. Campos-Reyna&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;3&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;2&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;, Cinthya L. Aspajo-Villalaz&lt;sup&gt;3&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;1&lt;/sup&gt;, José L. Cruzado- Razco&lt;sup&gt;1&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ace Baehaki</style></author><author><style face="normal" font="default" size="100%">Rinto</style></author><author><style face="normal" font="default" size="100%">Muhammad Hendri</style></author><author><style face="normal" font="default" size="100%">Sabri Sudirman</style></author><author><style face="normal" font="default" size="100%">Jeny Pusphyta Buana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Proximate Composition and Antioxidant Activities of Vegetable Milk from Lotus Seeds (Nolumbo nucifera)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lotus seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Nolumbo nucifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Proximate</style></keyword><keyword><style  face="normal" font="default" size="100%">Vegetable Milk</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">427-433</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to proximate composition and antioxidant activities of vegetable milk from lotus seeds (&lt;em&gt;Nolumbo nucifera&lt;/em&gt;). The research method in this study used a randomized block design with 3 levels of treatment with 3 repetitions, the treatments used were: A0 = 100% soybean (Control), A1 = boiling temperature 80⁰C, A2 = boiling temperature 90⁰C, A3 = boiling temperature 100⁰C, B1 = boiling time 10 min, B2 = boiling time 30 min and B3 = boiling time 50 min. The test parameters carried out were proximate composition (water, ash, protein, fat, carbohydrates, and antioxidants) and antioxidant activiy. The results showed the ash content of the lotus seed until the boiling time of 90 min increased, but when the temperature was increased to 100⁰C, the ash content decreased. The fat content of lotus seed milk decreased with increasing boiling time. The protein of vegetable milk from lotus seeds tend to increase with the duration of boiling. The result showed the soy milk has the highest activity (control). For lotus seed milk, the highest activity was in lotus seed milk with boiling temperature treatment of 80⁰C and boiling time for 10 min.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">427</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ace Baehaki&lt;sup&gt;1,&lt;/sup&gt;*, Rinto&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hendri&lt;sup&gt;2&lt;/sup&gt;, Sabri Sudirman&lt;sup&gt;1&lt;/sup&gt;, Jeny Pusphyta Buana&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Indralaya, South Sumatera, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Study Program of Marine Sciences, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya, Indralaya, South Sumatera, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Qualitative and Quantitative Analysis of 70% Ethanol Extract from Ruta angustifolia for Developing Anti-Hepatitis C Agents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatitis C Virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Infectious disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Ruta angustifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Rutin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">682-687</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Medicinal plants are potential sources for drug candidates. It possesses with various metabolites which have many pharmacology effects. &lt;em&gt;Ruta angustifolia&lt;/em&gt; is one of medicinal plants that has been used traditionally for liver disease. Previous study it has been demonstrated to inhibit hepatitis C virus under in vitro cell culture. It decreased protein NS3 level and gave synergistic effect in combination with simeprevir and telaprevir. This plant provides a prospective candidate to develop as anti-HCV Objective: This study evaluates the phytochemistry screening for qualitative assay and determine the concentration of rutin as marker compound for developing &lt;em&gt;R. angustifolia&lt;/em&gt; extract as anti-HCV agent.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;R. angustifolia&lt;/em&gt; leaves were extracted with 70% of ethanol. Extract and rutin were analysis their anti-HCV activity by in vitro culture cells of Huh7it. The concentration of rutin was determine by TLC densitometry. &lt;strong&gt;Results:&lt;/strong&gt; The 70% ethanol extract of &lt;em&gt;R. angustifolia &lt;/em&gt;dan rutin exhibit anti-HCV activities with IC&lt;sub&gt;50&lt;/sub&gt; value of 2.9 ± 0.8 μg/ml and 28.1 ± 5.6 μg/ml, respectively. Screening phytochemistry demonstrated to contain flavonoid, terpenoid, alkaloid and polyphenols. TLC densitometry analysis yield the concentration of rutin in extract 0.06 %. &lt;strong&gt;Conclusion:&lt;/strong&gt; Extract of 70% ethanol of &lt;em&gt;R. angustifolia &lt;/em&gt;has a potential anti-HCV activity. Extract of &lt;em&gt;R. angustifolia&lt;/em&gt; may provide a good candidate for developing anti-HCV agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Tutik Sri Wahyuni&lt;sup&gt;1,2,&lt;/sup&gt;*, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;1,2&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Science, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ehab M Mostafa</style></author><author><style face="normal" font="default" size="100%">Mohammed Gamal</style></author><author><style face="normal" font="default" size="100%">Mohammed M Ghoneim</style></author><author><style face="normal" font="default" size="100%">Shaimaa Hussein</style></author><author><style face="normal" font="default" size="100%">Ahmed H El-Ghorab</style></author><author><style face="normal" font="default" size="100%">Mohamed A Abdelgawad</style></author><author><style face="normal" font="default" size="100%">Arafa Musa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Repurposing of FDA Approved Alkaloids as COVID 19 Inhibitors; in silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloids</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Docking study</style></keyword><keyword><style  face="normal" font="default" size="100%">FDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural drugs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">110-123</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Alkaloid drugs were permitted for using as a treatment of numerous diseases. Colchicine, codeine, piperine, papaverine, ergometrine, theophylline, theobromine and caffeine are recognized safe alkaloids and used for many human disfunctions. The chemical structures of alkaloids have flexible chemical moieties with various electronic and chemical characters. COVID-19 is a horrible disease as result from that the discovering of potent drugs from previously FDA approved drugs is the main objective of this study. &lt;strong&gt;Methods:&lt;/strong&gt; docking studies were used for discovering the interactions of alkaloids with protease proteins. The nature of selected alkaloids structures was utilized for advance insights studies to predict new medical applications. &lt;strong&gt;Results: &lt;/strong&gt;Docking studies for alkaloids were completed and the obtained outcomes, displayed that all tried alkaloids have great attraction with the five protease proteins, the energy docking score ranged from -2.9516 (for colchicine with 5R82) to -24.7449 (for ergotamine with 5R80) kcal/mol with 1-5 variable interactions bond. &lt;strong&gt;Conclusion: &lt;/strong&gt;Among the tested drugs, papaverine and ergometrine revealed high docking scores for all five proteins (score ranged from, -14.1058 to 23.1619 for papaverine and, -4.7900 to 24.7449 for ergometrine) and number of interactions with all tested proteins are two to three for papaverine but for ergometrine are two to five.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">110</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ehab M. Mostafa&lt;sup&gt;1&lt;/sup&gt;, Mohammed Gamal&lt;sup&gt;2&lt;/sup&gt;, Mohammed M. Ghoneim&lt;sup&gt;3&lt;/sup&gt;, Shaimaa Hussein&lt;sup&gt;4&lt;/sup&gt;, Ahmed H. El-Ghorab&lt;sup&gt;5&lt;/sup&gt;, Mohamed A. Abdelgawad&lt;sup&gt;2,&lt;/sup&gt;*, Arafa Musa&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Department, College of Pharmacy, Jouf University, Sakaka, Aljouf, 72341, KSA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, 72341, KSA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, College of Pharmacy, Al Maarefa University, Ad Diriyah 13713, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Aljouf 72341, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Chemistry Department, College of Science, Jouf university, Sakaka, Aljouf 72341, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Okid Parama Astirin</style></author><author><style face="normal" font="default" size="100%">Adi Prayitno</style></author><author><style face="normal" font="default" size="100%">Anif Nur Artanti</style></author><author><style face="normal" font="default" size="100%">Elisa Herawati</style></author><author><style face="normal" font="default" size="100%">Afiyati Nur ‘Aini Saad</style></author><author><style face="normal" font="default" size="100%">Ajeng Dara Firstlia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Single-Dose and Combined-Dose of Nanoparticles from Soursop Leaves (Annona muricata L.) and Sappan Wood (Caesalpinia sappan L.) Induced Apoptosis and Necrosis in HeLA Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan L.</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1134-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Apart from the medical advancement of chemotherapy, various plants were known as beneficial for cancer therapy because they can kill cancer cells selectively without damaging the normal cells. Here, we showed that nanoparticles formulated from chloroform fraction of soursop (&lt;em&gt;Annona muricata&lt;/em&gt; L.) leaves and ethyl acetate fraction of sappan wood (&lt;em&gt;Caesalpinia sappan&lt;/em&gt; L.) have anti-proliferative and cytotoxic effects on HeLa cervical cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The cytotoxic effect was evaluated using a single dose of each nanoparticle and a combined dose to obtain a synergistic effect. The mechanism of induced cell death via apoptosis or necrosis pathway was evaluated using flow cytometry by incorporating Annexin V and propidium iodide.&lt;strong&gt; Results: &lt;/strong&gt;Synthesis of nanoparticles from the extract of soursop leaves (nano-SL) and extract of sappan wood (nano-SW) yielded particle sizes ranging from 248 to 317 nm. Nano-SL and nano-SW decreased the viability of HeLa cervical cancer cells in a dose-dependent manner with IC&lt;sub&gt;50 &lt;/sub&gt;values of 63,32 μg/ml dan 40,88 μg/ml, respectively. The combined dose of 1/8 IC&lt;sub&gt;50&lt;/sub&gt; from both nanoparticles showed a strong synergistic effect, as shown by the combination index value of 0.13 based on the same mode of action and different modes of action. In HeLa cells treated with a combined dose of nanoparticles, the total apoptotic cells increased two times greater than that in control cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;Nano-SL and nano-SW induce apoptosis and necrosis in HeLa cells. Combined-dose of both nanoparticles produced a synergistic effect that could reduce the amount of the required individual dose while increasing the total effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1134</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Okid Parama Astirin&lt;sup&gt;1&lt;/sup&gt;, Adi Prayitno&lt;sup&gt;2&lt;/sup&gt;, Anif Nur Artanti&lt;sup&gt;3&lt;/sup&gt;, Elisa Herawati&lt;sup&gt;1,&lt;/sup&gt;*, Afiyati Nur ‘Aini Saad&lt;sup&gt;1&lt;/sup&gt;, Ajeng Dara Firstlia&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathobiology, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Vocational College, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Friardi Ismed</style></author><author><style face="normal" font="default" size="100%">Awaliana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization Extracts and Simplicia of Limau Sundai Peel (Citrus x aurantiifolia 'sundai'), Determine Content of Nobiletin and Antibacterial Activity Test</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Citrus x aurantiifolia('sundai')</style></keyword><keyword><style  face="normal" font="default" size="100%">Nobiletin</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">Sundai lime peel fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC Densitometry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1323-1331</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: One type of oranges typical of West Sumatra, which is widely used as traditional medicine is sundai lime (&lt;em&gt;Citrus &lt;/em&gt;x &lt;em&gt;aurantiifolia&lt;/em&gt; 'sundai'); &lt;strong&gt;Aims:&lt;/strong&gt; therefore, it is necessary to standardize extracts and Simplicia, determine the content of nobiletin, and antibacterial activity test. &lt;strong&gt;Methods&lt;/strong&gt;: The standardization method was used refer to Farmakope Herbal Indonesia. TLC Densitometry was used to determine the content of the nobiletin, and the diffusion method to antibacterial activity test. To get a good standardization, the sundai lime was taken from three regions: Bukittinggi, Pariaman, and Solok. &lt;strong&gt;Results: &lt;/strong&gt;From these three regions, conclusions drawn from the macroscopic fruit peel slices were uneven and had distinctive odors. The outer surface is brown, and the inner surface is yellowish-white. From the microscopic was identified fragments in sundai lime peels consisting of hair covering, ladder-shaped transport, parenchyma with secretion cells, oxalate crystals, and parenchyma tissue and stomata. Water-soluble extract content of Simplicia ≤ 24.90 %, and ethanol-soluble extract content ≤ 17.66 %. Non-specific parameters are loss on drying ≤ 5.65 %, total ash content ≤ 5.14 %, and acid insoluble ash content ≤ 0.80 %. The specific parameters were crude extract, black, characteristic odor, Rf of nobiletin was 0.75. Rendement extract ≥ 18.80 %. Non-specific parameters of extract were water content ≤ 18.37 %, total ash content ≤ 3.93 %, and non-acidic ash content ≤ 0.27 %. The nobiletin content in the sundai lime extract Pariaman was 0.33 %, Solok 0.59 %, and Bukittinggi 0.47 %. The antibacterial test with diffusion method in three regions has moderate activities as concentrations of 20% and 15%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Sundai lime had Antibacterial activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1323</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Friardi Ismed, Awaliana&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suparmi</style></author><author><style face="normal" font="default" size="100%">Dewita</style></author><author><style face="normal" font="default" size="100%">Desmelati</style></author><author><style face="normal" font="default" size="100%">Taufik Hidayat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of the Making of Hydrolizate Protein Powder of Rebon Shrimp as a Food Nutrition Enhancement Ingredient</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetes erythreaeus</style></keyword><keyword><style  face="normal" font="default" size="100%">Dextrin</style></keyword><keyword><style  face="normal" font="default" size="100%">Gum arabic</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrolyzate</style></keyword><keyword><style  face="normal" font="default" size="100%">L plantarum sp</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1180-1185</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Rebon shrimp protein hydrolyzate has the potential to be used as a protein powder as a nutritional supplement. The aim of this study was to determine the best protein hydrolyzate concentration as a raw material for protein powder. The research was carried out in two stages, each of which was related. The first stage was made of protein hydrolyzate using 2 treatments, namely enzymatic hydrolysis (15% papain) and fermentation using 10%&lt;em&gt; L plantarum&lt;/em&gt; bacteria. The parameters observed included yield, amino acid profile and fatty acid profile. The second stage was determining the best concentration of 5 level (6%, 7%, 8%, 9%) protein hydrolyzate, as a binder was added gum arabic and dextrin (1: 0.5) the amount of 8% (w / v). observed parameters, organoleptic values, physical characteristics and degree of brightness. The results of this research can be concluded that the hydrolyzate of rebon shrimp protein with the best concentration is 9%. can be used as a protein powder as a nutritional supplement with the addition of gum arabic binder and dextrin (1: 0.5) with a yield value of 73.191% and a total amino acid of 46.70%. The content of fatty acids produced The fatty acids contained are mMyristic acid 0.264%, palmintic acid 6.361%, stearic acid 0.678%, oleic acid 16.704% (Omega 9) and linoleic acid 0.084% (Omega 6). Organoleptic value of protein powder, namely taste 8.6, aroma 8.4, appearance 8.8, texture 8.5, with the characteristics of a bright yellowish white color, not fishy aroma, fine texture and very savory taste (umami), the brightness value at the level of 97.82%.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1180</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suparmi&lt;sup&gt;1,&lt;/sup&gt;*, Dewita&lt;sup&gt;1&lt;/sup&gt;, Desmelati&lt;sup&gt;1&lt;/sup&gt;, Taufik Hidayat&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Aquatic Product Technology, Faculty of Fisheries and Marine Science, University of Riau, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Agency for Assesment and Aplication of Technology, Laptiab Building Puspiptek Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Numlil Khaira Rusdi</style></author><author><style face="normal" font="default" size="100%">Weri Lia Yuliana</style></author><author><style face="normal" font="default" size="100%">Erni Hernawati Purwaningsih</style></author><author><style face="normal" font="default" size="100%">Andon Hestiantoro</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Subchronic Toxicity of Lunasin Targeted Extract (ET-Lun) from Soybean Seed (Glycine max (L.) Merr.): Perspective from Liver Histopathology, SGOT, and SGPT Levels in Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Lunasin</style></keyword><keyword><style  face="normal" font="default" size="100%">SGOT</style></keyword><keyword><style  face="normal" font="default" size="100%">SGPT</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1384-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Lunasin Targeted Extract (ET-Lun) has a pharmacology effect in inhibiting inflammation by decreasing COX-2 and iNOS expression. ET-Lun could increase apoptosis and decrease dysplasia (p &amp;gt; 0,05). In addition, ET-Lun could decrease EGFR expression in breast cancer rats. The acute toxicity showed ET-Lun has LD50 more than 5000 mg/kg BW and was practically non-toxic. Objective: this study aimed to determine the subchronic toxicity of ET-Lun. &lt;strong&gt;Methods: &lt;/strong&gt;Male and female Sprague Dawley rats (n=40) were divided into 4 groups, the control group and treatment group ET-Lun dose of 250 mg/Kg BW, 500 mg/kg BW, and 750 mg/kg BW. The ET-Lun was administered for 90 days. On the 91st day, the animals were dissected and examined for SGOT-SGPT levels, liver histopathology, and diameter of the central vein.&lt;strong&gt; Results:&lt;/strong&gt; The SGOT-SGPT levels showed no significant difference between the treatment group and the control group (p &amp;gt; 0.05). On microscopic observation, there was no change or damage to the liver of rats in each group. The diameter of the central vein of the rat liver shows no significant difference between the control and treatment groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ET-Lun does not produce adverse effects in liver rats after subchronic treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1384</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Numlil Khaira Rusdi&lt;sup&gt;1,2&lt;/sup&gt;, Weri Lia Yuliana&lt;sup&gt;2&lt;/sup&gt;, Erni Hernawati Purwaningsih&lt;sup&gt;3,4&lt;/sup&gt;, Andon Hestiantoro&lt;sup&gt;5&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;1,4,6,7,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">María V González-Blas</style></author><author><style face="normal" font="default" size="100%">Orlando E Pretel-Sevillano</style></author><author><style face="normal" font="default" size="100%">Marco L Salazar-Castillo</style></author><author><style face="normal" font="default" size="100%">Maricielo Vaella-Alarcón</style></author><author><style face="normal" font="default" size="100%">Franco Huaccha-Cáceres</style></author><author><style face="normal" font="default" size="100%">Jonatam León-Soto</style></author><author><style face="normal" font="default" size="100%">Whendy Alaya-Davirán</style></author><author><style face="normal" font="default" size="100%">Anabel D. González-Siccha</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Luz M. Guerrero-Espino</style></author><author><style face="normal" font="default" size="100%">Julio Hilario-Vargas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz &amp; Pav.) Mez. Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gastric ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Indomethacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1072-1078</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Determine the content of total phenols and evaluate the gastroprotective effect of the extract of &lt;em&gt;Persea caerulea (&lt;/em&gt;Ruiz &amp;amp; Pav.) Mez. in mice with induced gastric ulcer. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The bark of &lt;em&gt;Persea caerulea &lt;/em&gt;was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups &lt;em&gt;P. caerulea &lt;/em&gt;treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. &lt;strong&gt;Results:&lt;/strong&gt; Higher percentages of gastric ulcer inhibition were obtained in the &lt;em&gt;P. caerulea&lt;/em&gt; 100 mg/kg (80%) and &lt;em&gt;P. caerulea &lt;/em&gt;200 mg/kg (85.71%) groups. &lt;strong&gt;Conclusions:&lt;/strong&gt; Extract of &lt;em&gt;Persea caerulea &lt;/em&gt;(Ruiz &amp;amp; Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1072</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abhel A. Calderón-Peña&lt;sup&gt;1,&lt;/sup&gt;*, Cinthya L. Aspajo-Villalaz&lt;sup&gt;1&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, María V. González-Blas&lt;sup&gt;2&lt;/sup&gt;, Orlando E. Pretel-Sevillano&lt;sup&gt;1&lt;/sup&gt;, Marco L. Salazar-Castillo&lt;sup&gt;1&lt;/sup&gt;, Maricielo Vaella-Alarcón&lt;sup&gt;1&lt;/sup&gt;, Franco Huaccha- Cáceres&lt;sup&gt;1&lt;/sup&gt;, Jonatam León-Soto&lt;sup&gt;1&lt;/sup&gt;, Whendy Alaya-Davirán&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;2&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, Luz M. Guerrero-Espino&lt;sup&gt;3&lt;/sup&gt;, Julio Hilario-Vargas&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Relin Yesika</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Activity of Kincung Flowers (Etlingera Elatior (Jack) R.M.Sm.) on Total Leukocytes and Percentage of Leukocytes in Allergic Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allergies</style></keyword><keyword><style  face="normal" font="default" size="100%">Etlingera elatior (Jack) R.M.Sm</style></keyword><keyword><style  face="normal" font="default" size="100%">Kincung Flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte Percentage</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Total Leukocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">44-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Kincung Flower (&lt;em&gt;Etlingera elatior &lt;/em&gt;(Jack) R.M.Sm.) is a native herbal plant in Southeast Asia that traditionally used to many diseases, especially in Indonesia. &lt;strong&gt;Aim: &lt;/strong&gt;This study was conducted to determine the activity of kincung (&lt;em&gt;Etlingera elatior&lt;/em&gt; (Jack) R.M.Sm.) on the total number of leukocytes and differential leukocyte cells in allergic mice.&lt;strong&gt; Material and Methods:&lt;/strong&gt; The semi-solid extract of Kincung flower (&lt;em&gt;Etlingera elatior &lt;/em&gt;(Jack) R.M.Sm.) was made by the maceration method using 70% ethanol solvent. The animals used were 20 male white mice that have allergies of skin that treated with 20% albumen antigens given on the first day 0.2 mL/20 g intraperitoneally, then on the seventh day are given antigens with the same dose subcutaneously. Allergic mice indicated by redness at the injection site. It divided into four groups: the negative control group and three dose groups (100; 300; and 1000 mg/kg). On the seventh day after administration of the extract, observed the value of total leukocytes and differential leukocyte cells in mice. &lt;strong&gt;Results:&lt;/strong&gt; The results after administration of extracts in 3 dose groups (100; 300; and 1000 mg / kg) and the negative control group showed sequentially the total number of leukocytes was: 3.95; 4.73; 6.01; and 3.6 x103/μL and the percentage of leukocytes consisting of lymphocytes: 67.6%; 62.0%; 56.8% and 70.0%, neutrophils: 22.4%; 29.2%; 36.8% and 20.0%, eosinophils: 6.4%; 5.8%, 4.2% and 6.6%, monocytes: 3.6%; 3.0%, 2.2% and 3.4%, and basophils: 1.8%; 1.4; 0.8% and 2.0%. It concluded that kincung flowers could increase total leukocytes significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), decrease lymphocytes, eosinophils, basophils significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), increase neutrophils significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05), and reduce monocytes insignificantly (&lt;em&gt;p&lt;/em&gt;&amp;gt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Kincung flowers (&lt;em&gt;Etlingera Elatior&lt;/em&gt; (Jack) R.M.Sm.) can be used as an immunomodulator and decreasing the percentage of basophil cells, and eosinophils can used as an anti-allergic drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">44</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yufri Aldi*, Elidahanum Husni, Relin Yesika &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwi Susiloningrum</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Myrna Adianti</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Mulyadi Tanjung</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Alkaloid Fraction from Melicope latifolia Leaves Inhibits Hepatitis C Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-HCV</style></keyword><keyword><style  face="normal" font="default" size="100%">Melicope latifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">N-methylflindersine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">535-540 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Hepatitis C Virus (HCV) is a major health problem, which infects approximately 170 million people among worldwide population. Moreover, there is no vaccine available to prevent HCV infection and the current anti-HCV drugs have not covered all the various genotypes and subtypes. Meanwhile, medicinal plants have been widely used to treat a variety of infectious disease. Our previous study reported that ethanol extract of &lt;em&gt;Melicope latifolia &lt;/em&gt;has been shown to exert anti-HCV activity towards a number of different virus genotypes with mainly inhibition mechanism at the entry step. Further separation was needed to purify and identify the active anti-HCV constituent using bioactivity-guided isolation method.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; Anti-HCV assay was performed using hepatocyte cell line (Huh7it) and HCV genotype 2a (JFH1). The purification of &lt;em&gt;M. latifolia &lt;/em&gt;ethanol extract (B1F) was done by liquid-liquid fractionation, vacuum liquid chromatography (VLC), and high-performance liquid chromatography (HPLC). The active fraction was further identified by thin layer chromatography (TLC) and the major constituent was determined by nuclear magnetic resonance (NMR) spectra data analysis. &lt;strong&gt;Results: &lt;/strong&gt;The fractionation of &lt;em&gt;M. latifolia&lt;/em&gt; leaves ethanol extract resulted an alkaloid fraction (B1F D2H.3) containing a major constituent N-methylflindersine. This alkaloid fraction was active to reduce HCV JFH1 with an inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) value of 6.21 µg/mL, a cytotoxicity concentration (CC&lt;sub&gt;50&lt;/sub&gt;) value of 82.64 µg/mL, and a selectivity index value of 13.31. &lt;strong&gt;Conclusion: &lt;/strong&gt;An alkaloid fraction of &lt;em&gt;M. latifolia&lt;/em&gt; (B1F D2H.3) was known to have major compound named N-methylflindersine. This alkaloid fraction exhibited strong anti-HCV against JFH1 &lt;em&gt;in vitro&lt;/em&gt;. The results indicated that this alkaloid fraction may a good candidate for anti-HCV agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">535</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwi Susiloningrum&lt;sup&gt;1&lt;/sup&gt;, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Myrna Adianti&lt;sup&gt;2,3&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Tutik Sri Wahyuni&lt;sup&gt;2,4&lt;/sup&gt;, Mulyadi Tanjung&lt;sup&gt;2,5&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;2,4&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;2,4&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Traditional Medicine Study Program, Faculty of Vocational, Universitas Airlangga, Surabaya 60286, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Abdur Rauf</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author><author><style face="normal" font="default" size="100%">Victor Fernández-Guzmán</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticarcinogenic agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Preventive medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">562-568 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To determine the ameliorative effect of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. &lt;strong&gt;Methods: &lt;/strong&gt;36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. &lt;strong&gt;Results: &lt;/strong&gt;Hematology showed that the triglyceride level was significantly lowered (P&amp;lt; 0.01) and high-density lipoprotein (HDL) level was significantly increased (P &amp;lt;0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P &amp;lt;0.01) and malondialdehyde level (P&amp;lt;0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P&amp;lt;0.01). &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt;&lt;strong&gt; &lt;/strong&gt;Chuquiraga spinosa&lt;/em&gt; showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;2,&lt;/sup&gt;*, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Abdur Rauf&lt;sup&gt;4&lt;/sup&gt;, Renán Hañari-Quispe&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa-Salvador&lt;sup&gt;6&lt;/sup&gt;, Victor Fernández-Guzmán&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Human Medicine, School of Pharmacy and Biochemistry, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, University of Swabi, Swabi-23430, KPK, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinic Pathology, Faculty of Veterinary medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Graduate School of Business, ESAN University, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Erwin Mulyawan</style></author><author><style face="normal" font="default" size="100%">Muhammad Ramli Ahmad</style></author><author><style face="normal" font="default" size="100%">Andi Asadul Islam</style></author><author><style face="normal" font="default" size="100%">Muh Nasrum Massi</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">Syafri Kamsul Arif</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of GABRB3 Protein Level After Administration of Valerian Extract (Valeriana officinalis) in BALB/c mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">BALB/c mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Diazepam</style></keyword><keyword><style  face="normal" font="default" size="100%">GABRB3 protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Valerian extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">821-827</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Valeriana officinalis is most commonly used as traditional medicine. Valerenic acid is the primary component of Valerian officinalis which inhibits the catabolism of enzyme induced breakdown of gamma amino butyric acid (GABA) in the brain, resulting in sedation. The aim of this study is to determine the level of GABRB3 protein, as part of major inhibitory neurotransmitter in the brain, after administration of Valerian extracts in BALB/c mice. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; This is an experimental study using animal model with post test-only controlled group design. Twenty healthy adult male BALB/c mice were randomly divided into four groups, negative control group (Aquadest), positive control group (Diazepam 0.025 mg/10 g), first treatment group (Valerian extract 2.5 mg/10 g) and second treatment group (Valerian extract 5 mg/10 g). The drugs were administered via gastric gavage for seven consecutive days. The blood was drawn from each mice on the first day (before treatment) and on the seventh day of experiment (2 hours after treatment). The blood sample was examined by enzyme-linked immunosorbent assay (ELISA) to determine the GABRB3 protein level. &lt;strong&gt;Results: &lt;/strong&gt;GABRB3 protein level in BALB/c mice after administration of Valerian extract was increased significantly in both treatment group (&lt;em&gt;p &lt;/em&gt;&amp;lt;0.0001). The highest increment in protein levels was found in the first treatment group with an increase of 2.988 μmol/L, compared with the second treatment group with an increase of 2.146 μmol/L. &lt;strong&gt;Conclusion: &lt;/strong&gt;GABRB3 protein level in BALB/c mice were increased after administration of Valerian extract. Administration of higher dose does not yield in higher GABRB3 protein level nor sedative effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">821</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Erwin Mulyawan&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Ramli Ahmad&lt;sup&gt;2&lt;/sup&gt;, Andi Asadul Islam&lt;sup&gt;3&lt;/sup&gt;, Muh. Nasrum Massi&lt;sup&gt;4&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;4&lt;/sup&gt;, Syafri Kamsul Arif&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology, Faculty of Medicine, Pelita Harapan University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology, Intensive Care and Pain Management, Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ace Baehaki</style></author><author><style face="normal" font="default" size="100%">Herpandi</style></author><author><style face="normal" font="default" size="100%">Susi Lestari</style></author><author><style face="normal" font="default" size="100%">Muhammad Hendri</style></author><author><style face="normal" font="default" size="100%">Febri Ariska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity with N-Hexane, Ethyl-Acetate and Ethanol Extract of Halodule uninervis Seagrass</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Haludule uninervis</style></keyword><keyword><style  face="normal" font="default" size="100%">Seagrass</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">805-808</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The purpose of this research was to observe the antidiabetic activity from N-hexane, ethylacetate and ethanol extract of &lt;em&gt;Halodule uninervis &lt;/em&gt;seagrass&lt;em&gt;.&lt;/em&gt; The antidiabetic activity with extract concentrations of 125 ppm, 250 ppm, 500 ppm, 1000 ppm and 2000 ppm from seagrass extract with ethanol solvent showed that it had the ability as an anti-diabetic agent stronger than seagrass extract with n-hexane and ethyl acetate solvents. Calculation of IC&lt;sub&gt;50&lt;/sub&gt; of &lt;em&gt;Halodule uninervis&lt;/em&gt; seagrass with ethanol extract was 74.99 ppm and ethyl acetate was 1,517,05 ppm. Glukobay as control was 0.27 ppm.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">805</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ace Baehaki&lt;sup&gt;1,&lt;/sup&gt;*, Herpandi&lt;sup&gt;1&lt;/sup&gt;, Susi Lestari&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hendri&lt;sup&gt;2&lt;/sup&gt;, Febri Ariska&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Study Program of Fisheries Product Technology, Faculty of Agriculture, Sriwijaya University, Indralaya, South Sumatera, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Study Program of Marine Sciences, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Indralaya, South Sumatera, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fania El Ridhasya</style></author><author><style face="normal" font="default" size="100%">Novia Rahim</style></author><author><style face="normal" font="default" size="100%">Muhammad Almurdani</style></author><author><style face="normal" font="default" size="100%">Rudi Hendra</style></author><author><style face="normal" font="default" size="100%">Hilwan Yuda Teruna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Constituents from Helminthostachys zeylanica (L) Hook (Ophioglossaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Helminthostacys zeylanica</style></keyword><keyword><style  face="normal" font="default" size="100%">Ophioglossaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">223-226</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The roots of tunjuk langit (&lt;em&gt;Helminthostacshys zeylanica&lt;/em&gt;) have been used traditionally in some villages in Indonesia, particularly in Riau Province. &lt;strong&gt;Objective:&lt;/strong&gt; In this study we reported two flavonoids and their antidiabetic activity. &lt;strong&gt;Material and methods: &lt;/strong&gt;Isolation of the metabolites was based on polarity fractionation method. Purification processes were conducted by vacuum liquid chromatography (VLC). Chemical structures were elucidated based on spectroscopy characteristics, including FTIR and 1D/2D NMR. &lt;strong&gt;Results: &lt;/strong&gt;The isolated compounds were identified as ugonin J and K. The antidiabetic activity was measured by &lt;em&gt;α&lt;/em&gt;-glucosidase inhibitor assay. The antidiabetic activity of ugonin J was found at IC&lt;sub&gt;50&lt;/sub&gt; 273,13±0,402 ppm and Ugonin K was found at IC&lt;sub&gt;50 &lt;/sub&gt;138,21±0,263 ppm (moderately active). &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore this plant can be used traditionally as antidiabetic medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">223</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fania El Ridhasya, Novia Rahim, Muhammad Almurdani, Rudi Hendra, Hilwan Yuda Teruna* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Pekanbaru 28293, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yesi Desmiaty</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Elastase, Anti-Tyrosinase and Anti-Oxidant of Rubus Fraxinifolius Stem Methanolic Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-Elastase</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tyrosinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Rubus fraxinifolius stem</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">271-275</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Some Rubus were reported had anti-skin aging activity. &lt;em&gt;Rubus fraxinifolius &lt;/em&gt;was one of Rubus genus which lives in Indonesian highland.&lt;strong&gt; Objective: &lt;/strong&gt;This study was to examine elastase, tyrosinase, and oxidant inhibitory activity of &lt;em&gt;R. fraxinifolius &lt;/em&gt;stem (RFS) extract. &lt;strong&gt;Methods: &lt;/strong&gt;Extraction was done by a Soxhlet apparatus using methanol as solvent. Elastase inhibition activity was determined, which based on the formation of p-nitroaniline. Tyrosinase inhibition activity evaluated based on inhibition of mushroom tyrosinase by the sample with L-DOPA as substrate. The activity of antioxidant was determined using the DPPH radical scavenger method. LC-MS was used for prediction of naturally occurring phytochemicals. &lt;strong&gt;Results: &lt;/strong&gt;The RFS extract yield was 9.03 %. The RFS extract revealed inhibition activity against elastase and tyrosinase with IC&lt;sub&gt;50&lt;/sub&gt; 128.85 ppm, and 155.19 ppm, respectively. DPPH radical scavenging activity gave IC&lt;sub&gt;50&lt;/sub&gt; 63.04 ppm. Total phenolic content of the extract was 387.99+3.21 mg GAE/g extract. The LC-MS analysis showed the presence of at least 13 different organic compounds in RFS extract, which might contribute to the bioactivity. &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, this experiment further proved that RFS extract might be useful as a natural product ingredient of anti-photoaging skincare products because of its ability to inhibit elastase, tyrosinase, and as an antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">271</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yesi Desmiaty&lt;sup&gt;1,2&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2,3&lt;/sup&gt;, Rini Prastiwi&lt;sup&gt;4&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Pancasila Univercity, Jakarta, 12640, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Chemistry Research Centre, Indonesian Institute of Sciences (LIPI), PUSPIPTEK Serpong, 15314, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Universitas Muhammadiyah Prof. Dr Hamka, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anis Yohana Chaerunisaa</style></author><author><style face="normal" font="default" size="100%">Muhaimin Muhaimin</style></author><author><style face="normal" font="default" size="100%">Syamsurizal Syamsurizal</style></author><author><style face="normal" font="default" size="100%">Harizon Harizon</style></author><author><style face="normal" font="default" size="100%">Tiana Milanda</style></author><author><style face="normal" font="default" size="100%">Imam Adi Wicaksono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antifungal Activity of Neolignan Derivatives from Eusideroxylon zwageri Against Pathogenic Fungus Microsporum gypseum</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Eusiderin</style></keyword><keyword><style  face="normal" font="default" size="100%">Eusideroxylon zwageri</style></keyword><keyword><style  face="normal" font="default" size="100%">Microsporum gypseum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">993-999</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Bulian wood (&lt;em&gt;Eusideroxylon zwageri&lt;/em&gt;) known as iron wood. It was known as wood source which fungi and insect resistant. These effects were interconnected with secondary metabolites contained within. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;Eusideroxylon zwageri&lt;/em&gt; wood powder was macerated with methanol and fractinated with n-Hexane, dichloromethane, ethyl acetate. Eusiderin I and Compound B were isolated from n-hexane fraction, while Compound C were isolated from dichloromethane fraction. Eusiderin I, compound A and Compound B were characterized using melting point, UV spectroscopy and compared with previous data. Antifungal activity test was conducted with &lt;em&gt;Microsporum gypseum&lt;/em&gt; using paper disc method. &lt;strong&gt;Results: &lt;/strong&gt;A research on antifungal activity of Neolignan derivatives from &lt;em&gt;Eusideroxylon zwageri &lt;/em&gt;against pathogenic fungus &lt;em&gt;Microsporum gypseum &lt;/em&gt;had been carried out. Eusiderin I, Compound B and Compound C were isolated from wood of &lt;em&gt;Eusideroxylon zwageri&lt;/em&gt;. All three compounds are white crystals with melting point in such 99-100 oC, 110-112 oC, 98-99 oC, respectively and UV spectrum data is similar to reference. The antifungal activity test of Eusiderin I, Compound B and Compound C from Bulian wood (&lt;em&gt;Eusideroxylon zwager&lt;/em&gt;i) to phatogen fungus of &lt;em&gt;Microsporum gypseum &lt;/em&gt;showed that with five different concentrations (5, 25, 50, 100 and 200 ppm), Eusiderin I was a potent antifungal because it had a strong activity in inhibiting the&lt;em&gt; Microsporum gypseum &lt;/em&gt;growth. The 5 days incubation test result showed that 50 ppm Eusiderin I could inhibit the &lt;em&gt;Microsporum gypseum&lt;/em&gt; colony growth. The 100 ppm Eusiderin I gave the most effective inhibition precentage because it could inhibit the &lt;em&gt;Microsporum gypseum &lt;/em&gt;colony growth (= 93.9%). &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on this data, Eusiderin I can be indicated an antifungal candidate.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">993</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anis Yohana Chaerunisaa&lt;sup&gt;1,&lt;/sup&gt;*, Muhaimin Muhaimin&lt;sup&gt;2,3&lt;/sup&gt;, Syamsurizal Syamsurizal&lt;sup&gt;2,3&lt;/sup&gt;, Harizon Harizon&lt;sup&gt;2&lt;/sup&gt;, Tiana Milanda&lt;sup&gt;4&lt;/sup&gt;, Imam Adi Wicaksono&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutic and Pharmaceutical Technology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry Education, Faculty of Education, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, University of Jambi, Jambi, 36361, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Padjadjaran University, Jatinangor, 45363, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aprilita Rina Yanti Eff</style></author><author><style face="normal" font="default" size="100%">Hermanus Ehe Hurit</style></author><author><style face="normal" font="default" size="100%">Sri Teguh Rahayu</style></author><author><style face="normal" font="default" size="100%">Muhammad Unggul Januarko</style></author><author><style face="normal" font="default" size="100%">Putu Gita Maya WM</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antihypertensive, Antidiabetic, Antioxidant and Cytotoxic Activities of Indonesian Traditional Medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ACE inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Jamu</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1623-1629</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Indonesian people have long used herbal medicine (jamu) to overcome various diseases, including hypertension and diabetes mellitus. Hypertension and diabetes mellitus are two diseases that are directly related and require proper and thorough management. &lt;strong&gt;Objectives: &lt;/strong&gt;The present study investigated the antihypertensive, antidiabetic, and cytotoxic activities ethanol extracts of Indonesian traditional medicine (jamu). Material and Methods: Jamu was extracted by maceration using ethanol. Antihypertensive and antidiabetic activity investigated by measurement of ACE inhibitor, an alpha-glucosidase inhibitor, and antioxidant activity at a concentration ranging from 125-1000 μg/mL, respectively, by in vitro method. Cytotoxic evaluation of the extract was carried out using Brine Shrimp Lethality Test (BSLT). &lt;strong&gt;Results:&lt;/strong&gt; measurements of ACE inhibitors, alpha-glucosidase inhibitor and antioxidant activity showed that herbal extracts had ACE inhibitors, alpha-glucosidase inhibitors, and antioxidant activity with IC50 values of 292.15 μg/mL, 36.13 μg/mL, and 24.43 μg/mL respectively. Ethanol extract of herbal medicine (jamu) exerts a cytotoxic effect on larvae of shrimp &lt;em&gt;Artemia salina&lt;/em&gt; with an IC50 value of 215.04 μg/mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;Jamu extract has antihypertensive and antidiabetic activity in vitro and cytotoxic effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1623</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aprilita Rina Yanti Eff&lt;sup&gt;1,&lt;/sup&gt;*, Hermanus Ehe Hurit&lt;sup&gt;1&lt;/sup&gt;, Sri Teguh Rahayu&lt;sup&gt;1&lt;/sup&gt;, Muhammad Unggul Januarko&lt;sup&gt;2&lt;/sup&gt;, Putu Gita Maya WM&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy Faculty of Health Science, Esa Unggul University, Jakarta, 1150, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Management Faculty Economics and Bussiness, Esa Unggul&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agriana Rosmalina Hidayati</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Hilkatul Ilmi</style></author><author><style face="normal" font="default" size="100%">Mulyadi Tanjung</style></author><author><style face="normal" font="default" size="100%">Tri Widiandani</style></author><author><style face="normal" font="default" size="100%">Siswandono</style></author><author><style face="normal" font="default" size="100%">Din Syafruddin</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial Activity of Flavonoid Compound Isolated from Leaves of Artocarpus altilis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Artocarpus altilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cysteine protease inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Dihydrochalcones</style></keyword><keyword><style  face="normal" font="default" size="100%">P. falciparum 3D7</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">835-842</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Artocarpus altilis&lt;/em&gt; leaves extract has previously been reported as a potential antimalarial drug. Inhibition concentration (IC&lt;sub&gt;50&lt;/sub&gt;) against &lt;em&gt;P. falciparum&lt;/em&gt; and effective dose values (ED&lt;sub&gt;50&lt;/sub&gt;) against P. berghei have been reported at 1.32 μg/ml and 0.82 mg/kg, respectively. The aim of this study is to identify the active compound from the ethanol extract of &lt;em&gt;A. Altilis&lt;/em&gt; leaves against &lt;em&gt;P. falciparum.&lt;/em&gt; Materials and Methods: The isolation of the active compound from the ethanol extract of&lt;em&gt; A. altilis &lt;/em&gt;were conducted using chromatography methods, and the chemical structure of the isolated compounds was determined based on NMR and MS spectra data. Antimalarial assay was determined using microscopic method against &lt;em&gt;P. falciparum&lt;/em&gt; 3D7 and molecular docking studies was performed using Molegro Virtual Docker version 5.5 program. &lt;strong&gt;Results:&lt;/strong&gt; A flavonoid compound, class of dihydrochalcone was finally isolated from &lt;em&gt;A. altilis &lt;/em&gt;and identified as&lt;em&gt; 1-(2,4-dihydroxy phenyl)-3-[8-hydroxy-2-methyl-2-(4-methyl-3- pentenyl)-2H-1-benzopyran-5-yl]-1-propanone&lt;/em&gt; (Compound-1). Antimalarial activity test revealed that the compound strongly inhibited &lt;em&gt;P. falciparum&lt;/em&gt; growth, with IC&lt;sub&gt;50&lt;/sub&gt; value of 1.05 μM. An in silico study to determine the mechanism of action of the compound revealed the existence a 3.BPF receptor that possesses a cysteine protease inhibitor of falcipain-2. &lt;strong&gt;Conclusion: &lt;/strong&gt;Compound-1 were isolated from the leaves of &lt;em&gt;A. Altilis&lt;/em&gt; is a good candidate of new source in the development of antimalarial drugs. An animal study using this compound is recommended before a clinical trial.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">835</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Agriana Rosmalina Hidayati&lt;sup&gt;1,2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;3,4,&lt;/sup&gt;*, Hilkatul Ilmi&lt;sup&gt;4&lt;/sup&gt;, Mulyadi Tanjung&lt;sup&gt;4,5&lt;/sup&gt;, Tri Widiandani&lt;sup&gt;6&lt;/sup&gt;, Siswandono&lt;sup&gt;6&lt;/sup&gt;, Din Syafruddin&lt;sup&gt;7,8&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;3,4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Post Graduate Student of Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Mataram, Mataram 83125, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60826, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Departement of Pharmaceutical Chemistry Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Eijkman Institute for Molecular Biology, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Parasitology, Faculty of Medicine, Hasanuddin University, Makassar 90245, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Malatee Tayeh</style></author><author><style face="normal" font="default" size="100%">Poonsit Hiransai</style></author><author><style face="normal" font="default" size="100%">Hathaichanok Kommen</style></author><author><style face="normal" font="default" size="100%">Ramida Watanapokasin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-migration and Anti-invasion Abilities of Methanolic Leaves Extract of Clerodendrum Inerme on Lung Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-invasion</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-migration</style></keyword><keyword><style  face="normal" font="default" size="100%">Clerodendrum inerme</style></keyword><keyword><style  face="normal" font="default" size="100%">Human lung adenocarcinoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1024-1031</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Clerodendrum inerme &lt;/em&gt;is a folk medicinal plant used in the treatment of various illnesses such as a cough, scrofulous infection, venereal infection, skin diseases and tumors. It exhibited many pharmacological effects including hepatoprotective, anti-inflammatory, antibacterial, anti-oxidant and anticancer properties. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study was to investigate the influence of methanolic extract of&lt;em&gt; C. inerme&lt;/em&gt; leaves on migration, invasion and adhesion activities on human lung adenocarcinoma. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Cytotoxicity, cell motility, migration, invasion and adhesion abilities were detected by MTT, wound healing, trans-well mobilization, modified Boyden chamber and cell adhesion assay, respectively. &lt;strong&gt;Results: &lt;/strong&gt;The results demonstrated that up to 400 μg/mL methanolic leaves extract has low toxicity on A549 cells showing more than 50% cell viability. At non-cytotoxic and sub-toxic doses (200 and 400 μg/mL) of methanolic leave extract significantly suppressed cell motility, migration, invasion and cell adhesion compared with the untreated control. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggested that methanolic leaves extract of &lt;em&gt;C. inerme &lt;/em&gt;inhibited migration, invasion and adhesion of A549 cells. These findings showed new therapeutic potential for &lt;em&gt;C. inerme&lt;/em&gt; in anti-metastatic therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1024</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Malatee Tayeh&lt;sup&gt;1,&lt;/sup&gt;*, Poonsit Hiransai&lt;sup&gt;1&lt;/sup&gt;, Hathaichanok Kommen&lt;sup&gt;2&lt;/sup&gt;, Ramida Watanapokasin&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Sciences, Walailak University, Nakhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Srinkharinwirot University, Bangkok 10110, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Yesi Desmiaty</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Antioxidant Activity of Sterculia stipulata Korth Woods and Leaves by FRAP Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia stipulata Korth</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">236-239</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Phenol compounds and flavonoids are known have antioxidant activity. &lt;em&gt;Sterculia &lt;/em&gt;genus has secondary metabolite rich of phenols and flavonoids. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study of the activity antioxidants of &lt;em&gt;Sterculia stipulata&lt;/em&gt; Korth. Woods and leaves by FRAP method. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Extraction done using n-hexane, ethyl acetate, and methanol. The methanol extract was determined antioxidant activity using the FRAP method and also determined the total phenols content, total flavonoids, and phytochemical screening. &lt;strong&gt;Results:&lt;/strong&gt; The antioxidant activity of wood extract was 4.74 ± 1.03 FeEAC (mol/g) while leaves extract 41.17 ± 1.99 FeEAC (mol/g). Total phenols content for wood extract 16.46 ± 3.51 mg GAE/g, for leaves extract 141.62 ± 10.54 mg GAE/g. The total flavonoids content for woods extract was 27.99 ± 0.62 mg QE/g for leaf extract 41.45 ± 5.83 mg QE/g. The compounds of woods and leaves are the same; it is consist of terpenoids, alkaloids, phenols, flavonoids, saponins, terpenoids, and negatives for anthraquinone. &lt;strong&gt;Conclusion: &lt;/strong&gt;The antioxidant activity of the leaves of &lt;em&gt;Sterculia stipulata&lt;/em&gt; Korth. is greater than its wood activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">236</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;3,4&lt;/sup&gt;, Yesi Desmiaty&lt;sup&gt;2&lt;/sup&gt;, Rani Sauriasari&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof. Dr. Hamka University, 1340 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong (LIPI Indonesia), INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy Phytochemistry, Faculty of Pharmacy Universitas Pancasila, Jakarta, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Indonesia University, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Almurdani</style></author><author><style face="normal" font="default" size="100%">Adel Zamri</style></author><author><style face="normal" font="default" size="100%">Titania T Nugroho</style></author><author><style face="normal" font="default" size="100%">Jasril Karim</style></author><author><style face="normal" font="default" size="100%">Yum Eryanti</style></author><author><style face="normal" font="default" size="100%">Rudi Hendra</style></author><author><style face="normal" font="default" size="100%">Hilwan Yuda Teruna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Antidiabetic Activities of Mempening (Lithocarpus bancanus) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lithocarpus bancanus</style></keyword><keyword><style  face="normal" font="default" size="100%">Talang Mamak Tribe</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">328-334</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Lithocarpus bancanus &lt;/em&gt;or commonly called as mempening in Talang Mamak Tribe, Indonesia is a plant that is used as a traditional medicine.&lt;strong&gt; Objective: &lt;/strong&gt;This study aim to evaluated antioxidant and antidiabetic activities of &lt;em&gt;L. bancanus&lt;/em&gt; leaves extract. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The methanol extract was obtained by maceration of the leaves. The n-hexane, dichloromethane and ethyl acetate fractions were prepared by successive partition process of the methanol extract. Antioxidant activities were evaluated by various antioxidant assays, including DPPH (1,1-diphenyl-2-picrylhydrazyl), FRAP (ferric reducing antioxidant power), CUPRAC (&lt;em&gt;cupric reducing antioxidant capacity&lt;/em&gt;), and ABTS (&lt;em&gt;2,2’-azonobis 3-ethylbenzothiazoline-6-sulfonic acid&lt;/em&gt;) method. Total phenolics were estimated based on the Folin–Ciocalteu method, while, aluminum chloride methods were employed to estimate total flavonoids. Antidiabetic activies was determined by inhibiting the activity of α-glucosidase method. Results: antioxidant activity assay against DPPH radical as well as the total phenolic and flavonoid content of &lt;em&gt;L. bancanus&lt;/em&gt; leaves showed that the methanol extract possessed IC&lt;sub&gt;50&lt;/sub&gt; value of 39.469 ± 0.273 μg/mL with total phenol and flavonoid were 11.426 ± 0.432 mg GAE/g dry weight sample and 15.423 ± 0.213 mg QE/g respectively. The FRAP, CUPRAC and ABTS values of methanol extract were 3494.302 ±0.456, 26665.501 ± 5.940 and 2857.977 ± 0.715 μM TE/g dry weight sample respectively. Antidiabetic activity of methanol extract with IC&lt;sub&gt;50&lt;/sub&gt; value of 30.565 ± 0.331 μg/mL. Conclusion: It could be concluded that leaves of &lt;em&gt;L. bancanus&lt;/em&gt; have antioxidant and antidiabetic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">328</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Almurdani&lt;sup&gt;1&lt;/sup&gt;, Adel Zamri&lt;sup&gt;1&lt;/sup&gt;, Titania T. Nugroho&lt;sup&gt;1&lt;/sup&gt;, Jasril Karim&lt;sup&gt;1&lt;/sup&gt;, Yum Eryanti&lt;sup&gt;1&lt;/sup&gt;, Rudi Hendra&lt;sup&gt;1&lt;/sup&gt;, Hilwan Yuda Teruna&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Riau, Pekanbaru 28293, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Howaida Ibrahim Abd-Alla</style></author><author><style face="normal" font="default" size="100%">Magda Tohamy Ibrahim</style></author><author><style face="normal" font="default" size="100%">Hanan Anwar Aly Taie</style></author><author><style face="normal" font="default" size="100%">Marwa Abas Hasan</style></author><author><style face="normal" font="default" size="100%">Nagwa M M Shalaby</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and the Efficacy of Sophora secundiflora and Methoxyisoflavones in the Immune Function of Pigeons Vaccinated against Paramyxovirus Serotype-1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiradical effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Immune</style></keyword><keyword><style  face="normal" font="default" size="100%">Isoflavones</style></keyword><keyword><style  face="normal" font="default" size="100%">Paramyxovirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Pigeons</style></keyword><keyword><style  face="normal" font="default" size="100%">Sophora secundiflora</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1276-1288</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present work investigated the effect of oral administration of hydroalcoholic (70% aqueous ethanol) extract (TeE) of &lt;em&gt;Sophora secundiflora&lt;/em&gt; leaves and its organic fractions n-hexane (HeE), ethyl acetate (EaE) and n-butanol (BuE) and major isolated methoxyisoflavones &lt;strong&gt;1&lt;/strong&gt; and&lt;strong&gt; 2,&lt;/strong&gt; on the cellular and humoral immune responses to live attenuated avian paramyxovirus-1 (APMV-1) vaccines in pigeons. &lt;strong&gt;Methods:&lt;/strong&gt; The structures of six isolated compounds were elucidated on the basis of chromatographic, chemical, and spectroscopic methods. The samples antioxidative and radical scavenging capabilities of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical cation and ferric reducing power were determined. Total phenolic, tannin and flavonoid contents of EaE extract were evaluated. &lt;strong&gt;Results:&lt;/strong&gt; Six compounds were isolated. Three were the methoxyisoflavones5- 7-dihydroxy-4′-methoxyisoflavone &lt;strong&gt;(1),&lt;/strong&gt; 7-hydroxy-4′methoxyisoflavone&lt;strong&gt; (2),&lt;/strong&gt; 5,4'-dihydroxy-7- methoxy-isoflavone&lt;strong&gt; (3),&lt;/strong&gt; along with isorhamnetin &lt;strong&gt;(4)&lt;/strong&gt; and two quercetin derivatives quercetin 3-glucoside &lt;strong&gt;(5) &lt;/strong&gt;and quercetin 3-rutinoside &lt;strong&gt;(6) &lt;/strong&gt;were isolated. The hydroalcoholic extract, fractions and 4'-methoxyisoflavones showed radical scavenging effect in the order of EaE &amp;gt; TeE &amp;gt; BuE &amp;gt;compound&lt;strong&gt; 1&amp;gt;&lt;/strong&gt;compound&lt;strong&gt; 2&amp;gt;&lt;/strong&gt; HeE. Stimulation of both sero-responses was observed, especially this of EaE. The results showed an increase of macrophage cells, lymphocyte and antibody titers in blood. &lt;strong&gt;Conclusion:&lt;/strong&gt; The presence of 5-hydroxyl group at A-ring may be important to show the immunostimulant and antioxidant activity of compound &lt;strong&gt;1&lt;/strong&gt;vs compound &lt;strong&gt;2&lt;/strong&gt;. The present results showed the potential abilities of EaE as antioxidant and immunomodulator agent and these would impart healthy economic benefits in vaccinated birds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Howaida Ibrahim Abd-Alla&lt;sup&gt;1,&lt;/sup&gt;*, Magda Tohamy Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Hanan Anwar Aly Taie&lt;sup&gt;3&lt;/sup&gt;, Marwa Abas Hasan&lt;sup&gt;4&lt;/sup&gt;, Nagwa M. M. Shalaby&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry of Natural Compounds, National Research Centre, El-Bohouth Street, National Research Centre, Giza-Dokki 12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Pharmacy, Sinai University, Kantara Branch, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Plant Biochemistry Department, National Research Centre, Giza-Dokki 12622, EGYPT. 4Bab El-Shaariya University Hospital, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tutik Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Hak Hotta</style></author><author><style face="normal" font="default" size="100%">Chie Aoki-Utsubo</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiviral Activity of Indonesian Medicinal Plants against Hepatitis B Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curcuma xanthorhiza</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis B Virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1108-1114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hepatitis B virus (HBV) infects more than 300 million people globally and is a common cause of liver cancer. Current therapy using reverse transcriptase inhibitors require long-term treatment and the potential risk of development of drug-resistant viruses remains an important issue to be considered. Hence, the development of new drugs is critical. Traditional medicinal plants used for the treatment of infectious diseases may provide a viable option for the discovery of anti-HBV drug candidates. &lt;strong&gt;Objective: &lt;/strong&gt;This study examined anti-HBV activity of 31 kinds of Indonesian plants. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Crude extracts of various part of plants, leaves and stem, were obtained using dichloromethane and ethanol solvent. The effect on viral entry was examined by determining levels of HBsAg expression in the supernatants of HBV-infected HepG2-NTCP cells by ELISA. The effect on HBV replication was determined by measuring HBV DNAs amounts in Hep38.7-Tet cells by quantitative real-time PCR.&lt;strong&gt; Results: &lt;/strong&gt;The extracts of &lt;em&gt;Phyllantus niruri&lt;/em&gt; leaves and &lt;em&gt;Curcuma xanthorrhiza &lt;/em&gt;showed reduction of strong HBsAg production from HepG2-NTCP cells with IC&lt;sub&gt;50&lt;/sub&gt; values of 170.48 and 270.51 μg/mL, respectively. Treatment of HepAD38.7-Tet cells with &lt;em&gt;P. niruri &lt;/em&gt;and &lt;em&gt;C. xanthorhiza &lt;/em&gt;at the highest concentration while avoiding cytotoxicity reduced extracellular HBV DNA levels by 70% and 30 % of the untreated control respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;P. niruri &lt;/em&gt;inhibited both the entry and HBV replication, thus &lt;em&gt;P. niruri &lt;/em&gt;is a promising candidate for anti-HBV drug development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1108</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tutik Sri Wahyuni&lt;sup&gt;1,2,&lt;/sup&gt;*, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;1,2,&lt;/sup&gt; Hak Hotta&lt;sup&gt;3,4&lt;/sup&gt;, Chie Aoki-Utsubo&lt;sup&gt;4&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Tropical Disease, Universitas Airlangga, Jl. Mulyorejo, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Clinical Nutrition and Dietetics, Konan Women’s University, 6-2-23 Morikitamachi, Higashinada-ku, Kobe 658-0001, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health, Kobe University Graduate School of Health Sciences, 7-10-2, Tomogaoka, Suma-ku, Kobe 654-0142, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nadilla N Atikasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Arginase Inhibitory, Antioxidant Activity, Total Phenolic Content and Total Flavonoid Content of Ethyl Acetate Extract of Caesalpiniaturtuosa Roxb Stem Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Arginase</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpiniaturtuosa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">227-231</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this study is to investigate arginase inhibition, antioxidant activity, total phenolic content and total flavonoid content of ethyl acetate extract of &lt;em&gt;Caesalpiniaturtuosa &lt;/em&gt;Roxb. &lt;strong&gt;Material and method: &lt;/strong&gt;stem bark of &lt;em&gt;Caesalpiniaturtuosa &lt;/em&gt;Roxb was extracted using hexane, ethyl acetate and methanol subsequently. The ethyl acetate extract was fractioned. Then, the fractions were subjected to arginase inhibition, antioxidant activity, total phenolic content and total flavonoid assay. Correlation was considered by statistical analysis. &lt;strong&gt;Result: &lt;/strong&gt;Out of eight fractions, two fractions have no activity. Two fractions (3 and 6) have strong activity in arginase with inhibition 90.72 % and 91.41% respectively. Fraction 3 and 6 have strong antioxidant activity with IC&lt;sub&gt;50&lt;/sub&gt; 25.98 μg/mL and 48.01 μg/mL respectively. Statistical analysis shows arginase inhibitor activity was not related with antioxidant activity, total phenolic content and total flavonoid content in this plant. &lt;strong&gt;Conclusion:&lt;/strong&gt; Activity in arginase inhibition of fraction from ethyl acetate extract of &lt;em&gt;Caesalpiniaturtuosa &lt;/em&gt;Roxb are not related to antioxidant, total phenolic and flavonoid content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">227</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nadilla N. Atikasari&lt;sup&gt;1&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2,3&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Chemistry Indonesian Institute of Science (LIPI), Serpong, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Pancasila University, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dewita</style></author><author><style face="normal" font="default" size="100%">Syahrul</style></author><author><style face="normal" font="default" size="100%">Taufik Hidayat</style></author><author><style face="normal" font="default" size="100%">Mery Sukmiwati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Blending of Chorella Patin And Microalga Fish Oil as an Associated Chorella as Potential Health Food</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Catfish oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Chorella</style></keyword><keyword><style  face="normal" font="default" size="100%">Health food supplements</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1346-1350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The use of health food supplements based on functional food components at this time has become a necessity for the community to maintain their health at optimum level. Functional food from fishery products is a food that is considered effective, because in addition to alternative food sources, the nutritional content is very good for health. This study aimed to produce high nutritional health food supplements from raw materials of &lt;em&gt;Chorella&lt;/em&gt; enriched with catfish oil. The method used in making high nutritional health food supplements is a microencapsulation experimental method with different formulations. &lt;strong&gt;Methods:&lt;/strong&gt; The experiment used organoleptic test, chemical component test with amino acids (HPLC) and Fatty acids (GC). &lt;strong&gt;Result:&lt;/strong&gt; The results showed that the best formulations based on the profiles of amino acids, fatty acids and standard AAE per day, especially oleic and linoleic essential fatty acids were B formulations (2% &lt;em&gt;Chorella&lt;/em&gt;, and 1% fish oil.&lt;strong&gt; Conclusion:&lt;/strong&gt; The formulations B from the sample conducted in this research was the best formulations based on protein content, fat, essential amino acid profiles and essential fatty acids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1346</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dewita&lt;sup&gt;1,&lt;/sup&gt;*, Syahrul&lt;sup&gt;1&lt;/sup&gt;, Taufik Hidayat&lt;sup&gt;2&lt;/sup&gt;, Mery Sukmiwati&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Aquatic Product Technology Faculty Fisheries and Marine Science, University of Riau, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Agroindustry Technology, Agency of Assessment and Aplication of Technology, Puspiptek Serpong, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Faiza MOULAI-HACENE</style></author><author><style face="normal" font="default" size="100%">Mokhtaria Yasmina BOUFADI</style></author><author><style face="normal" font="default" size="100%">Soumia KEDDARI</style></author><author><style face="normal" font="default" size="100%">Abdelkader HOMRANI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Antimicrobial Properties of Elettaria cardamomum Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Elettaria cardamomum</style></keyword><keyword><style  face="normal" font="default" size="100%">Pathogenic strains</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1058-1063</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Cardamom, also known as&lt;em&gt; Elettaria cardamomum,&lt;/em&gt; a venerated perennial herb like the &quot;Queen of Spices&quot; belongs to the Zingiberaceae family. She holds various pharmacological activities due to its phytochemicals it contains such as; phenols, tannins, terpenoids, flavonoids, sterols. &lt;strong&gt;Methods: &lt;/strong&gt;The study included the determination of the chemical composition of&lt;em&gt; Elettaria cardamomum&lt;/em&gt; ethanolic extract (EEC) by HPLC/UV and evaluated their antimicrobial potential against ten pathogenic reference strains using two complementary techniques: the method of diffusion from solid discs and the determination of minimum inhibitory concentrations (MIC). &lt;strong&gt;Results:&lt;/strong&gt; The results obtained from chemical identification of the EEC showed the presence of polyphenolic acids (rosmarinic acid, caffeic acid, ferulic acid, etc.) and many flavonoids (kaempferol, chrysin, galangin, pinocembrine, quercetin, etc.). The results of the antimicrobial effect showed that the extract reacted positively on almost all the microbial strains tested. The EEC extract significantly inhibited the growth of microbial strains, with a broader antimicrobial spectrum with extensive action with inhibitory zones between 8 and 33 mm in diameter. Thus, this extract revealed a dose-dependent antimicrobial activity on these microbial strains used. However, the inhibitory potential of the cardamom extract was variable compared to their MIC ranging from 6.25 to 12.5 mg of dry extract/mL. Therefore, the strains least susceptible to EEC are &lt;em&gt;Bacillus subtilis, Escherichia coli, Aspergillus niger&lt;/em&gt; and&lt;em&gt; Candida albicans&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;This activity is due to the phenolic compounds produced by the EEC extract. This extract can be used for the development of plant medicines against microbial infections and fungal infestations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1058</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Faiza MOULAI-HACENE&lt;sup&gt;1&lt;/sup&gt;, Mokhtaria Yasmina BOUFADI&lt;sup&gt;2,3,&lt;/sup&gt;*, Soumia KEDDARI&lt;sup&gt;2&lt;/sup&gt;, Abdelkader HOMRANI&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Sciences and Techniques of Animal Production (LSTPA), Faculty of Natural Sciences and Life, Abdelhamid Ibn Badis University, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Beneficial Microorganisms, Functional Food and Health (LMBAFS), Faculty of Natural Sciences and Life, Abdelhamid Ibn Badis University, Mostaganem, ALGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Université Libre de Bruxelles, Brussels, BELGIUM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Diki Prayugo Wibowo</style></author><author><style face="normal" font="default" size="100%">Ria Mariani</style></author><author><style face="normal" font="default" size="100%">Siti Uswatun Hasanah</style></author><author><style face="normal" font="default" size="100%">Diah Lia Aulifa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Constituents, Antibacterial Activity and Mode of Action of Elephant Ginger (Zingiber officinale var. officinale) and Emprit Ginger Rhizome (Zingiber officinale var. amarum) Essential Oils</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical constituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Elephant ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">Emprit ginger</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">404-409</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Ginger (&lt;em&gt;Zingiber officinale&lt;/em&gt; Rosc) is a spice plant, which is extensively used worldwide, and morphologically classified into three types, including the red, “gajah” or “elephant”, and “emprit” ginger (common name in Indonesia). In addition, the extract and essential oils possess antibacterial pharmacological activities, due to the inherent constituents. The aim of this research, therefore, was to analyze the chemical constituents, test antibacterial activities, and observe the mode of action of elephant and emprit ginger rhizome essential oils. &lt;strong&gt;Methods:&lt;/strong&gt; Essential oils isolation was conducted using water and steam distillation method, while microdilution method was adopted in the testing for antibacterial activities against Gram positive and negative bacteria. Furthermore, the mode of action was evaluated using &lt;em&gt;Scanning Electron Microscopy&lt;/em&gt; (SEM). &lt;strong&gt;Results:&lt;/strong&gt; The antibacterial activity demonstrated antibacterial activities in the essential oils of elephant and emprit ginger rhizome, with minimal inhibition concentrations (MIC) value of 250-1000 μg.mL&lt;sup&gt;-1&lt;/sup&gt; and minimal bacterial concentrations (MBC) value of 500-1000 μg.mL&lt;sup&gt;-1&lt;/sup&gt;, while chemical evaluation showed the presence of 45 and 38 constituents, respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Both essential oils possess antibacterial activities against Gram positive and negative bacteria, with different strengths, which are based on chemical composition. Conversely, SEM micrographs demonstrated the ability for elephant and emprit ginger rhizome essential oils to change the morphology of bacteria.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">404</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Diki Prayugo Wibowo&lt;sup&gt;1&lt;/sup&gt;, Ria Mariani&lt;sup&gt;2&lt;/sup&gt;, Siti Uswatun Hasanah1, Diah Lia Aulifa&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Indonesian School of Pharmacy (Sekolah Tinggi Farmasi Indonesia). Jl. Soekarno Hatta No. 354, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biology, Garut University. Jl. Jati 42, Garut, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afaf E Abdel Ghani</style></author><author><style face="normal" font="default" size="100%">Sayed AA El-Toumy</style></author><author><style face="normal" font="default" size="100%">Wagdi IA El-Dougdoug</style></author><author><style face="normal" font="default" size="100%">Ahmed M Mansour</style></author><author><style face="normal" font="default" size="100%">Wafaa HB Hassan</style></author><author><style face="normal" font="default" size="100%">Hanaa M Hassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Profile and Hepatoprotective Activity of Ethyl Acetate Extracts of Euphorbia paralias and Euphorbia geniculata (Euphorbiaceae) from Egypt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Euphorbia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">UPLC-ESI-MS/MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">762-770</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Plants belonging to the genus Euphorbia were used traditionally to treat several health disorders and diseases. &lt;strong&gt;Objective:&lt;/strong&gt; the aim of this study is evaluation of secondary metabolites and hepatoprotective activity of the ethyl acetate fractions of the aerial parts of &lt;em&gt;Euphorbia paralias &lt;/em&gt;(&lt;em&gt;Ep&lt;/em&gt;) and &lt;em&gt;Euphorbia geniculata&lt;/em&gt; (&lt;em&gt;Eg&lt;/em&gt;). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;UPLC-ESI-MS/ MS technique was used for identification of the secondary metabolites. The hepatoprotective potential of the two plants was evaluated for the first time in male rats with thioacetamide induced liver injury. &lt;strong&gt;Results: &lt;/strong&gt;A total of 32 secondary metabolites were identified in the ethyl acetate fractions of the aerial parts of both species. Ellagitannins such as tetragalloyl hexoside, ellagic acid, gallic acid, and flavonoids such as kaempferol-3-O-β-(6''-galloyl-Oglucopyranoside), quercetin glycosides (glucoside and arabinoside) were found to be the major components in &lt;em&gt;Ep &lt;/em&gt;whereas flavonoid glycosides including quercetin rutinoside, quercetin glycosides (glucoside, arabinoside and rhamnoside) and kaempeferol glycoside derivatives were highly abundant in &lt;em&gt;Eg. &lt;/em&gt;Administration of thioacetamide resulted in marked elevation in liver enzymes, elevation of lipid profile and alteration in oxidative stress parameters. While pretreatment of rats with &lt;em&gt;Ep&lt;/em&gt; and&lt;em&gt; Eg&lt;/em&gt; ethyl acetate fractions significantly attenuated the hepatic toxicity through reduction of liver biomarkers, improving the redox status of the tissue and so brought down the serum biochemical parameters and lipid profile nearly toward the normal levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;The studied fractions show hepatoprotective potential with promising value as hepatoprotective drugs of natural origin in comparison with silymarin as the standard hepatoprotective drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">762</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afaf E. Abdel Ghani&lt;sup&gt;1&lt;/sup&gt;, Sayed A. A. El-Toumy&lt;sup&gt;1&lt;/sup&gt;, Wagdi I. A. El-Dougdoug&lt;sup&gt;2&lt;/sup&gt;, Ahmed M. Mansour&lt;sup&gt;2&lt;/sup&gt;, Wafaa H. B. Hassan&lt;sup&gt;2&lt;/sup&gt;, Hanaa M. Hassan&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, 44519 Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry of Tannins, National Research Center, El-Dokki- Cairo, 12622 Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Organic Chemistry, Faculty of Science, Benha University, 13518 Benha, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology Faculty of Pharmacy, El-Alazhar University Cairo Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy Faculty of Pharmacy, Zagazig University,, Zagazig, Egypt.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacy department Banha Educational Hospital, 13518 Banha, Banha, Egypt.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vishnu Priya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Janardhana Papayya Balakrishna</style></author><author><style face="normal" font="default" size="100%">Gayathri Rengasamy</style></author><author><style face="normal" font="default" size="100%">Surapaneni Krishna Mohan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemopreventive Action of Garcinia Mangostana Linn. on Hepatic Carcinoma by Modulating Ornithine Decarboxylase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diethyl nitrosamine</style></keyword><keyword><style  face="normal" font="default" size="100%">G. Mangostana extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatocellularcarcinoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Ornithine decarboxylase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1383-1388</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Ornithine decarboxylase and alpha -L- fucosidase over-expression is associated with advanced hepatocellular carcinoma (HCC) development. The objective of this study was to elucidate the action of &lt;em&gt;Garcinia Mangostana &lt;/em&gt;fruit extract (GME) on these overexpressed enzymes and apoptotic proteins in diethyl nitrosamine (DEN) induced hepatocellular carcinoma (HCC) rats. The cancer was induced using DEN to the experimental rats and treated with GME (400 mg/ kg) to find its anticancer property. The lysosomal enzymes such as alpha-L-fucosidase, beta- D-glucosidase, ornithine decarboxylase activity (ODC), apoptotic and antiapoptotic proteins such as Bcl-2, Bax and Bcl-xl and H&lt;sup&gt;3&lt;/sup&gt; thymidine incorporation assay were done to prove GME’s chemo preventive property. DEN induction caused significant increase in the activities of ornithine decarboxylase; lysosomal enzymes and increased cell proliferation with decreased apoptosis were observed. In contrast, the groups with GME treated rat’s elicited significant (&lt;em&gt;P&lt;/em&gt; &amp;lt; 0.001) reduction in ornithine decarboxylase, lysosomal enzymes and decreased cell proliferation with increased apoptosis. GME has effective chemo preventive property and can serve as an anticarcinogenic therapeutic drug against hepatocellular carcinoma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1383</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vishnu Priya Veeraraghavan&lt;sup&gt;1,&lt;/sup&gt;*, Sardar Hussain&lt;sup&gt;2&lt;/sup&gt;, Janardhana Papayya Balakrishna&lt;sup&gt;3&lt;/sup&gt;, Gayathri Rengasamy&lt;sup&gt;4&lt;/sup&gt;, Surapaneni Krishna Mohan&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Government science College, chitradurga-577501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor,10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai – 600 123, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iman AA Kassem</style></author><author><style face="normal" font="default" size="100%">Ayman A Farghaly</style></author><author><style face="normal" font="default" size="100%">Neveen S Ghaly</style></author><author><style face="normal" font="default" size="100%">Zeinab M Hassan</style></author><author><style face="normal" font="default" size="100%">Marian Nabil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Composition and Genoprotective Effect of the Flavonoidal Content of Lepidium sativum L. Methanolic Seed Extract against Cyclophosphamide- Induced DNA Damage in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomal abberations</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipidium sativum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">124-130</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Lepidium sativum&lt;/em&gt; L. (Family Brassicaceae) is known to possess different pharmacological properties. &lt;strong&gt;Objective: &lt;/strong&gt;The genoprotective role of flavonoids of &lt;em&gt;L. sativum &lt;/em&gt;methanolic seed extract (LSF) against cyclophosphamide (CP)-induced DNA damage, in somatic and germ cells of mice, as well as characterization of the flavonoidal content were carried out in this study. Chromosomal aberration analysis in somatic and germ cells were also included. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Six mice groups were used for this study. Group 1 served as a negative control. Group 2 received oral LSF (100 mg/kg b.wt.) for 5 consecutive days. Group 3 served as a positive control by receiving a single intraperitoneal (i.p.) CP dose (20 mg/kg b.wt.). The three other groups were orally administered 25, 50 and 100 mg/kg b.wt. LSF, respectively, for 5 consecutive days. On the last day of treatment, the three groups received i.p. injection of CP (20 mg/kg b.wt.). Flavonoids were identified using spectral analysis.&lt;strong&gt; Results: &lt;/strong&gt;LSF inhibited DNA aberrations in mice caused by cyclophosphamide dose dependently in the three groups with significant difference in the two groups that received doses of 50 and 100 mg/kg b.wt. The chromosomal aberrations inhibitory indices were calculated as 18 and 31 in mice somatic cells and 27 and 48 in germ cells, respectively. LSF was found to contain the flavonoids kaempferol, quercetin, kaempferol-3-O-α-L-rhamnopyranoside, kaempferol-3-O-β-D-glucopyranoside, and quercetin-3-O-β-D-galactopyranoside. &lt;strong&gt;Conclusion: &lt;/strong&gt;LSF inhibited the DNA damage induced by CP in somatic and germ cells of mice dose-dependently. The antioxidant properties associated with flavonoids might account for the genoprotective activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">124</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Iman AA Kassem&lt;sup&gt;1,&lt;/sup&gt;*, Ayman A Farghaly&lt;sup&gt;2&lt;/sup&gt;, Neveen S Ghaly&lt;sup&gt;1&lt;/sup&gt;, Zeinab M Hassan&lt;sup&gt;1&lt;/sup&gt;, Marian Nabil&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Natural Compounds Department, National Research Centre, Dokki 12622, Giza, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Genetics and Cytology Department, National Research Centre, Dokki 12622, Giza, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marissa Angelina</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Franciscus D Suyatna</style></author><author><style face="normal" font="default" size="100%">Beti Ernawati Dewi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Drug of Action Cassia Alata Leaves Extract as Antiviral to Dengue Virus Serotype-2 in vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Cassia alata</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue virus</style></keyword><keyword><style  face="normal" font="default" size="100%">Early step</style></keyword><keyword><style  face="normal" font="default" size="100%">Post infection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">864-871</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Objectives: &lt;/strong&gt;Dengue viruses (DENV) is a mosquito-borne members of the Flaviridae family.To date, more than 2.5 billion people in over 100 countries are at risk of infection, and approximately 20 million infections were reported annually. Currently, There is no specific antiviral treatment available for DENV infection. Natural products possess a wide range of biological and biochemical potential. Among them, plants are one of the most important sources for discovering new drugs for therapy. Our previous study, showed that &lt;em&gt;Cassia alata&lt;/em&gt; has potency as antiviral to DENV, however drug of action still unclear. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; We explore the drug of action of C. alata leaves exract and its fraction through time of addition studies and effect of solvents wtih the dose based on the previous study. &lt;strong&gt;Results:&lt;/strong&gt; The most effective inhibition druf of action was determined by focus assay. Meanwhile the toxicity was measured by MTT assay. These studies demosntrated that ethanol extract of &lt;em&gt;Cassia alata&lt;/em&gt; 1 mg/ml showed strong inhibition in both early step (receptor and attachment to host cells) and post infection with inhibition 96.04 % and 99.16 %.Compared with those fractions, &lt;em&gt;Cassia alata&lt;/em&gt; ethanol extract has strongest inhibition DENV in every step of virus replication. &lt;strong&gt;Conclussion: &lt;/strong&gt;&lt;em&gt;Cassia alata&lt;/em&gt; ethanol extract has strongest inhibition DENV in every step of virus replication with the average of inhibition more than 95 %. Ethyl acetate and hexane has strongest inihibition with the average of inhibition 100 %.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">864</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marissa Angelina&lt;sup&gt;1,2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Franciscus D. Suyatna&lt;sup&gt;3&lt;/sup&gt;, Beti Ernawati Dewi&lt;sup&gt;4,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Programme in Biomedical Science Faculty of Medicine, University of Indonesia, Jl. Salemba Raya 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Chemistry LIPI , Kompleks Puspiptek Serpong 15416, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology and Therapeutics Faculty of Medicine- RSCM Universitas Indonesia, Jl. Salemba Raya 6, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departement of Microbiology Faculty of Medicine, Universitas Indonesia- Cipto Mangukusumo Hospital, Jalan Pengangsaan Timur No. 16 Jakarta 10320, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elham Akbari</style></author><author><style face="normal" font="default" size="100%">Kawsar Alami</style></author><author><style face="normal" font="default" size="100%">Dawood Hossaini</style></author><author><style face="normal" font="default" size="100%">Mohammad Latif Nazari</style></author><author><style face="normal" font="default" size="100%">Mohammad Hossein Salehi</style></author><author><style face="normal" font="default" size="100%">Meysam Sajjadi</style></author><author><style face="normal" font="default" size="100%">Sayed Yousof Mousavi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Afghan Saffron (Crocus sativus L.) Aqueous Extract on Withdrawal Signs in Morphine-Dependent Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aqueous extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Crocus</style></keyword><keyword><style  face="normal" font="default" size="100%">Morphine dependence</style></keyword><keyword><style  face="normal" font="default" size="100%">Withdrawal signs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1727-1731</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Opioid dependency, as a global problem is accompanied with serious personal, economic, social and hygienic disorders. Synthetic drugs beside their efficacies, have numerous adverse effects. As the medicinal plants have low costs and adverse effects, and they are also affective on different stages of dependency treatment, they attracted the attention of the researchers in the field of medicine. This study was aimed to investigate the effect of the aqueous extract of Afghan saffron on the withdrawal signs in morphine-dependent rats. &lt;strong&gt;Methods:&lt;/strong&gt; Rats divided into 5 groups (1 Normal Saline, 1 Morphine, and 3 Extract groups). The rats that received morphine and extract became morphine-dependent by subcutaneous (s.c.) administration of morphine hydrochloride for 7 days (2.5, 2.5, 5, 10, 20, 40 mg/kg doses twice daily on 1st to 6th days respectively, and a single dose of 50 mg/kg on 7th day). The extract groups received 100, 150 and 200 mg/kg doses of the saffron aqueous extract by intraperitoneal (i.p.) administration simultaneously with morphine. Two hours after the administration of the last dose of morphine, Naloxone (3 mg/kg, i.p.) was injected and withdrawal signs were noted for 30 minutes. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the administration of the saffron aqueous extract (100, 150 and 200 mg/kg) significantly decreased most of the withdrawal signs in morphine-dependent rats (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Afghan saffron aqueous extract can alleviate the withdrawal signs in morphine-dependent rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1727</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elham Akbari&lt;sup&gt;1&lt;/sup&gt;, Kawsar Alami&lt;sup&gt;1&lt;/sup&gt;, Dawood Hossaini&lt;sup&gt;1&lt;/sup&gt;, Mohammad Latif Nazari&lt;sup&gt;1&lt;/sup&gt;, Mohammad Hossein Salehi&lt;sup&gt;2&lt;/sup&gt;, Meysam Sajjadi&lt;sup&gt;1&lt;/sup&gt;, Sayed Yousof Mousavi&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research and Technology Center, Khatam Al-Nabieen University, Karte 4, 1st street, Kabul, AFGHANISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Kabul Medical University, Ataturk avenue, Jamal Mena, 3rd District, Kabul, AFGHANISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Khatam Al- Nabieen university, Karte 4, 1st street, Kabul, AFGHANISTAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Titik Sumarawati</style></author><author><style face="normal" font="default" size="100%">Ignatius Riwanto</style></author><author><style face="normal" font="default" size="100%">Soeharyo Hadisaputro</style></author><author><style face="normal" font="default" size="100%">Edi Dharmana</style></author><author><style face="normal" font="default" size="100%">Taufiqurachman Nasihun</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Phaleria macrocapa on Atrophy and Apoptosis of Intestinal Mucous Cell and Phalerin Concentration at Portal Vein and Systemic Circulation in Adenocarcinoma Mice following Adriamycine and Cyclophosphamide Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Atrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Concentration</style></keyword><keyword><style  face="normal" font="default" size="100%">Phalerin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">603-610 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Chemotherapy has been proven capable of reducing breast cancer cell progression; however the adverse effect also emerging. Thus, diminish those adverse effects with botanical product &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;(PM) as adjuvant therapy is necessary. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to evaluate the effect of PM treatment in combination with &lt;em&gt;adriamycine&lt;/em&gt; and cyclophosphamide (AC) on intestinal apoptosis and their correlation with phalerin concentration in systemic circulation. &lt;strong&gt;Methods: &lt;/strong&gt;In the experimental study, 30 female mice with adenocarcinoma were assign into 5 groups: Neg-G, only given aquadest; Portal vein group (PMV-G) and systemic circulation groups (PMC-G), were administered PM 0.146mg/day; Portal vein group (PMACV-G) and systemic circulation group (PMACC-G), were administered &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;0,146 mg orally, &lt;em&gt;Adriamycine &lt;/em&gt;0,013 mg and Cyclophosphamide 0,0156 mg singgle dose intravenously. Phalerin concentration was measured by HPLC methods at minute 30, 60, 90, 120, 150, and 180 after treatment. At the end of study, intestinal mucous cell apoptosis was identified by TUNEL methods. &lt;strong&gt;Results: &lt;/strong&gt;independent t test analyses showed that index of apoptosis of intestinal mucous cell were significant higher in PMAC-G compared to that of Neg-G and PM-G, p &amp;lt; 0.05. In contrary, phalerin concentration in PMAC-G was significant lower compared to that of PM-G, p &amp;lt; 0.05. The Pearson analysis indicated the inverse correlation (r= -736, p&amp;gt;0.05) between apoptosis index with phalerin concentration.&lt;strong&gt; Conclusion: &lt;/strong&gt;Treatment of PM in combination with AC has been proven able to increase intestinal mucous cell apoptosis and decrease phalerin concentration. However, the inverse correlation didnot exist.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">603</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Titik Sumarawati&lt;sup&gt;1,&lt;/sup&gt;*, Ignatius Riwanto&lt;sup&gt;2&lt;/sup&gt;, Soeharyo Hadisaputro&lt;sup&gt;3&lt;/sup&gt;, Edi Dharmana&lt;sup&gt;4&lt;/sup&gt;, Taufiqurachman Nasihun&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Medical Faculty of Sultan Islamic Agung University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Surgery, Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Internal Medicine Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Parasitology Medical Faculty of Diponegoro University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry Medical Faculty of Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ratika Rahmasari</style></author><author><style face="normal" font="default" size="100%">Takahiro Haruyama</style></author><author><style face="normal" font="default" size="100%">Muhareva Raekiansyah</style></author><author><style face="normal" font="default" size="100%">Farhana Mossadeque</style></author><author><style face="normal" font="default" size="100%">Marina Ika Irianti</style></author><author><style face="normal" font="default" size="100%">Ayun Erwina Arifianti</style></author><author><style face="normal" font="default" size="100%">Nobuyuki Kobayashi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Establishment of Simple Cell-based Screening Assay and the Identification of Potent Antiviral Activity of a Plant Extract against HSV-1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HSV-1</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural product activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Simple cell-based screening</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">251-259</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Backgrounds: &lt;/strong&gt;Drug screening is a time-consuming and costly process confronted with low productivity and challenges in using animals, which limits the discovery of new drugs. The cellbased assay allows the minimization of using the animal models and can provide more relevant &lt;em&gt;in vivo &lt;/em&gt;biological information than biochemical assay. &lt;strong&gt;Objective:&lt;/strong&gt; We aimed to establish a simple cell-based screening assay for the discovery of lead extract against HSV-1. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Assay setting up was performed by optimization of the cell, incubation time, virus titer, and determination of Z value. &lt;strong&gt;Results: &lt;/strong&gt;We have successfully established reproducible methods, by setting up assay plate including determination: 1) Vero cells as a model for HSV-1 infection, 2) Incubation for 5 days as sufficient time for CPE endpoint at monolayer cells, 3) 100 TCID&lt;sub&gt;50&lt;/sub&gt;/well HSV-1 as infection titer which caused high percentage of cell detachment, 4) determination of Z value of 100 TCID&lt;sub&gt;50&lt;/sub&gt;/well infection &amp;gt; 0.5. In addition, the established system was tested using ACV as the most common anti-HSV drug. Furthermore, we demonstrated the current system to screen extracts from &lt;em&gt;Acacia nilotica, Uncaria gambir &lt;/em&gt;and &lt;em&gt;Aspalathus linearis &lt;/em&gt;against HSV-1. It was observed that the alkaline extract of Uncaria gambir exhibited the highest SI (12.5) compared to other extracts. &lt;strong&gt;Conclusion: &lt;/strong&gt;We demonstrated current cellbased screening system was reproducible and able to identify lead extracts against HSV-1 infection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">251</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ratika Rahmasari&lt;sup&gt;1&lt;/sup&gt;, Takahiro Haruyama&lt;sup&gt;2&lt;/sup&gt;, Muhareva Raekiansyah&lt;sup&gt;3&lt;/sup&gt;, Farhana Mossadeque&lt;sup&gt;4&lt;/sup&gt;, Marina Ika Irianti&lt;sup&gt;1&lt;/sup&gt;, Ayun Erwina Arifianti&lt;sup&gt;1&lt;/sup&gt;, Nobuyuki Kobayashi&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Central Research Center, AVSS, Okinawa, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;PT Sciencewerke Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Tropical Medicine, Nagasaki University, Nagasaki, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Retno Susilowati</style></author><author><style face="normal" font="default" size="100%">Lailatul Khoiriyah</style></author><author><style face="normal" font="default" size="100%">Exma Mutatal Hikmah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Estrogenic Effect of the Leaves from Katuk (Sauropus androgynus L. Merr) on Vaginal and Endometrial Atrophy in Perimenopausal Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Endometrial atrophy</style></keyword><keyword><style  face="normal" font="default" size="100%">Estrogenic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Laboratory mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Perimenopause</style></keyword><keyword><style  face="normal" font="default" size="100%">S. androgynus leaf extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginal atrophy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">240-245</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To examine the potency of estrogenic effect of Katuk (or star gooseberry or sweet leaf) &lt;em&gt;Sauropus androgynus&lt;/em&gt; L. Merr (Phyllanthaceae) leaf extract on the vaginal and endometrial atrophy in perimenopausal mice model. &lt;strong&gt;Methods: &lt;/strong&gt;Completely random experiments divided into 4 groups with 5 female mice in each group: control group (N), perimenopause group which induced by 4-vynil cyclohexene dioxide (VCD) (P0), perimenopause group followed by &lt;em&gt;S. androgynus &lt;/em&gt;leaves extract administration with 15 and 30 mg/kg BW (P15 and P30). The mice were induced to artificial perimenopause with 160 mg/kg body weight (BW) of VCD 5 times/week for 2 weeks and continuously treated with &lt;em&gt;S. androgynus&lt;/em&gt; leaf extract for 30 days. Vaginal smear examination, maturation index (MI), vaginal epithelium and endometrial thickness were observed. Data were analyzed using a standard one-way ANOVA with LSD Test by SPSS 16.0 for Windows. &lt;strong&gt;Results: &lt;/strong&gt;Administration of &lt;em&gt;S. androgynus&lt;/em&gt; leaf extract for 30 days to perimenopausal mice model significantly decreased the duration of mice diestrus phase (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.01) compared to perimenopause mice.&lt;em&gt; S. androgynus &lt;/em&gt;leaf extract treatment at dose 30 mg/kg BW led to higher vaginal epithelium thickness and maturation index compared to another group (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.01). The effective dose to enhance the vaginal epithelial and endometrial cells proliferation was 30 mg/ kg BW. &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt; S. androgynus&lt;/em&gt; leaf extract had a good estrogenic action that it might be useful for therapy of vaginal and endometrial atrophy caused by perimenopause effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">240</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Retno Susilowati*, Lailatul Khoiriyah, Exma Mutatal Hikmah&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biology, Faculty of Science and Technology, State Islamic University of Maulana Malik Ibrahim Malang, Malang 65144, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Relin Yesika</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Extract of Kincung Flower (Etlingera elatior (Jack) R.M.Sm.) Activity to Decrease IL-4 and IgE Levels in Type I Hypersensitivity White Male Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Allergies</style></keyword><keyword><style  face="normal" font="default" size="100%">Etlingera elatior (Jack) R.M.Sm</style></keyword><keyword><style  face="normal" font="default" size="100%">IgE</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-4</style></keyword><keyword><style  face="normal" font="default" size="100%">Kincung Flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">682-686</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Kincung Flower (&lt;em&gt;Etlingera elatior&lt;/em&gt; (Jack) R.M.Sm.) is a herbal plant which contains many secondary metabolites. It showed to suppress allergic reactions by inhibiting mast cell degranulation, active cutaneous anaphylaxis and decreasing the number of basophils and eosinophils. &lt;strong&gt;Aim: &lt;/strong&gt;The study conducted to determine the decreased IL-4 and IgE level of type I hypersensitivity male white mice using kincung flowers extract. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The maceration method used to make ethanol extract of Kincung flower (&lt;em&gt;Etlingera elatior&lt;/em&gt; (Jack) R.M.Sm.). The research used 25 allergic male white mice, which made by injected 20% albumen that given on the first day 0.2 mL/20 g intraperitoneally. On the seventh day are given albumen with the same dose subcutaneously. The characteristic of the allergic mice is the redness at the injection site. It divided into five groups: the negative control group, the positive control group and three dose groups (100; 300; and 1000 mg/kg). After mice given extract for seven days, then measured IgE and IL-4 levels in the serum of mice. &lt;strong&gt;Results:&lt;/strong&gt; The results after three dose groups (100; 300; and 1000 mg/kg) given, the negative and positive control group showed sequentially the IL-4 level was: 33.024; 27.933; 25.192; 23.130 and 41.538 ng/ mL. And IgE level in serum was 0.944; 0.629; 0.210; and 1,597 μg/ mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;It concluded that kincung flowers decreased IL-4 and IgE level significantly (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). So it could use as an anti-allergic drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">682</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Relin Yesika, Yufri Aldi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Huynh Tan Hoi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Great Effect of Fallopia Multiflora and Other Herbs in Poliosis Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fallopia multiflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Folk treatment</style></keyword><keyword><style  face="normal" font="default" size="100%">Health</style></keyword><keyword><style  face="normal" font="default" size="100%">Poliosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1600-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Nowadays, many people with gray hair or poliosis soon lose their confidence in life. Early gray hair is not necessarily a sign of age, but also a disease of many causes. Although not dangerous to health, but gray hair soon loses the aesthetics, making us inferiority, inferiority complex in work and life. This article discusses some herbal remedies that Vietnamese use. Its effects are quite effective and help many people lead a healthier and more confident life.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1600</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Huynh Tan Hoi*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Language Department, FPT University, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ana L Agüero-Hernández</style></author><author><style face="normal" font="default" size="100%">Catalina Rosales-López</style></author><author><style face="normal" font="default" size="100%">Cristina Herrera</style></author><author><style face="normal" font="default" size="100%">Andrés Vargas-Picado</style></author><author><style face="normal" font="default" size="100%">Rodrigo Muñoz</style></author><author><style face="normal" font="default" size="100%">Ana Abdelnour-Esquivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoglycemic Effect of Kalanchoe pinnata (Lam) Pers. Leaf Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Kalanchoe pinnata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">557-561</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Kalanchoe pinnata &lt;/em&gt;(Lam) Pers (Crasulaceae) is a succulent ornamental plant. In Costa Rica, the leaves are used as a coadjuvant treatment for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; based on traditional knowledge of natural remedies. Moreover, there are some studies mentioning its use for &lt;em&gt;Diabetes Mellitus&lt;/em&gt; as medicinal plant in several countries. This research aimed to demonstrate the antidiabetic properties of hydroalcoholic extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves through phytochemical screening, alpha amylase inhibition and rodent models. &lt;strong&gt;Methods: &lt;/strong&gt;Crude extracts of &lt;em&gt;K. pinnata&lt;/em&gt; leaves were prepared by infusion and decoction using water:ethanol (70:30) as a solvent. The extracts prepared by decoction (LAED, lyophilized-water:ethanoldecoction) and by infusion (LAEI, lyophilized-water:ethanol-infusion) were analyzed by FolinCiocalteu, HPLC and capacity of inhibition of α-amylase activity. To determine hypoglycemic activity in rats, extracts were administered orally at doses of 250, 500 and 750 mg/Kg and blood sugar levels were monitored over a four hours period using a glucometer. &lt;strong&gt;Results:&lt;/strong&gt; A significant reduction (p &amp;lt; 0.05) in blood glucose was observed after one hour in rats treated with 500 mg/Kg of LAED extract. Treatment with 750 mg/Kg LAEI induced a statistically significant reduction in blood sugar at 90, 180 and 240 min, showing that the glucose-lowering effect of this extract was greater at a higher concentration. &lt;strong&gt;Conclusions: &lt;/strong&gt;This study confirmed the hypoglycemic effect of &lt;em&gt;K. pinnata&lt;/em&gt; extracts in the acute phase in rats and supports the use of this Crassulaceae as a home remedy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">557</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ana L. Agüero-Hernández&lt;sup&gt;1,&lt;/sup&gt;*, Catalina Rosales-López&lt;sup&gt;1&lt;/sup&gt;, Cristina Herrera&lt;sup&gt;2&lt;/sup&gt;, Andrés Vargas-Picado&lt;sup&gt;3&lt;/sup&gt;, Rodrigo Muñoz&lt;sup&gt;3&lt;/sup&gt;&lt;sup&gt;&amp;nbsp;&lt;/sup&gt;and Ana Abdelnour-Esquivel&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigación en Biotecnología (CIB), del Instituto Tecnológico de Costa Rica, Cartago, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José, COSTA RICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), San José, COSTA RICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fendi Yoga Wardana</style></author><author><style face="normal" font="default" size="100%">Defi Kartika Sari</style></author><author><style face="normal" font="default" size="100%">Myrna Adianti</style></author><author><style face="normal" font="default" size="100%">Adita Ayu Permanasari</style></author><author><style face="normal" font="default" size="100%">Lidya Tumewu</style></author><author><style face="normal" font="default" size="100%">Tomoyoshi Nozaki</style></author><author><style face="normal" font="default" size="100%">Aty Widyawaruyanti</style></author><author><style face="normal" font="default" size="100%">Achmad Fuad Hafid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Anti-Amebic Activity of Cage Xanthones from Cratoxylum sumatranum Stem Bark Against Entamoeba histolytica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amoebiasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactivity-guided isolation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cratoxylum sumatranum</style></keyword><keyword><style  face="normal" font="default" size="100%">Entamoeba histolytica</style></keyword><keyword><style  face="normal" font="default" size="100%">NAD kinase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">452-458</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Amoebiasis is caused by&lt;em&gt; Entamoeba histolytica,&lt;/em&gt; which is a pathogenic species living on human colon tissues. The development of new drugs for anti-amebic are still very needed for clinical treatment. &lt;strong&gt;Objective: &lt;/strong&gt;This aims to identify the compounds in &lt;em&gt;Cratoxylum sumatranum&lt;/em&gt; for their anti-amoeba activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;In this study we used bioactivity-guided isolation and structural analysis to identified anti-amebic compounds from dichloromethane extract of &lt;em&gt;Cratoxylum sumatranum&lt;/em&gt; stem bark. Their anti-amebic activity was determined by an &lt;em&gt;in vitro&lt;/em&gt; cell-based assay against&lt;em&gt; Entamoeba histolytica &lt;/em&gt;and an enzymatic assay on NAD kinase.&lt;strong&gt; Results:&lt;/strong&gt; Two known compounds from the cage xanthone groups, namely cochinchinoxanthone (1) and cochinchinone D (2), were isolated. The structures of the cage xanthone compounds were established by extensive spectroscopic data analysis. Compound (1) showed the greatest level of anti-amebic activity both in cell-based and enzymatic assay, yielding IC&lt;sub&gt;50&lt;/sub&gt; values of 4.57 and 12.17 μg/mL, respectively. In contrast, compound (2) yielded IC&lt;sub&gt;50&lt;/sub&gt; values of 5.19 and 12.60 μg/mL, respectively. Conclusion: When considering the demonstrated anti-amebic activities, it becomes apparent that these compounds, isolated from &lt;em&gt;Cratoxylum sumatranum &lt;/em&gt;stem bark, have the potential to be further developed into effective anti-amebic medicine against &lt;em&gt;Entamoeba histolytica.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">452</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Fendi Yoga Wardana&lt;sup&gt;1&lt;/sup&gt;, Defi Kartika Sari&lt;sup&gt;2&lt;/sup&gt;, Myrna Adianti&lt;sup&gt;2,3&lt;/sup&gt;, Adita Ayu Permanasari&lt;sup&gt;2&lt;/sup&gt;, Lidya Tumewu&lt;sup&gt;2&lt;/sup&gt;, Tomoyoshi Nozaki&lt;sup&gt;4&lt;/sup&gt;, Aty Widyawaruyanti&lt;sup&gt;2,5&lt;/sup&gt;, Achmad Fuad Hafid&lt;sup&gt;2,5,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Health, Faculty of Vocational Education, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of School of International Health, Laboratorium of Biomedical Chemistry, The University of Tokyo, Tokyo, 113-0033, JAPAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Universitas Airlangga, Surabaya, 60115, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dina M Eskander</style></author><author><style face="normal" font="default" size="100%">Sherien MM Atalla</style></author><author><style face="normal" font="default" size="100%">Ahmed A Hamed</style></author><author><style face="normal" font="default" size="100%">Ezzel -Din A El-Khrisy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Investigation of Secondary Metabolites and its Bioactivity from Sarocladium kiliense SDA20 Using Shrimp Shell Wastes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibiofilm activity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC/MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sarocladium kiliense SDA20</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolities</style></keyword><keyword><style  face="normal" font="default" size="100%">Shrimp waste shell</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">636-644 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In this study we isolated bioactive compounds using different chromatographic techniques from culture filtrate of &lt;em&gt;Sarocladium kiliense&lt;/em&gt; SDA20 grown in fermentation media containing shrimp shell waste as substrate under optimum conditions. Antibacterial and antibiofilm activities of crude extract and purified compounds were evaluated. &lt;strong&gt;Methods: &lt;/strong&gt;The test fungi strain&lt;em&gt; Sarocladium kiliense&lt;/em&gt; SDA20 was isolated from Egyptian soil and identified by18 S ribosomal RNA. Optimization conditions were carried out in fermentation media containing shrimp shell waste as sole carbon source, inoculated by 10&lt;sup&gt;6&lt;/sup&gt; spores/ml of &lt;em&gt;Sarocladium kiliense&lt;/em&gt; SDA20 at pH 7.0 produce 84.5% of the total toxins. Different chromatographic techniques for ethyl acetate extract of culture filtrate of fungi were used resulting in isolation of pure compounds were elucidated spectroscopically and comparing their data in literature. GC/MS analysis of extract was used for identification of other chemical compounds. Antibacterial and biofilm activity was evaluated using MTT assay. &lt;strong&gt;Results: &lt;/strong&gt;Five compounds for the first time were identified: Cholest-5-en-3-ol (C1), Palmitic acid (C2), Oleic acid (C3), Nicotinamide (C4), Tricin (C5). GC-MS analysis showed the presence of twenty-seven compounds. Antibacterial activity of crude and pure compounds displayed a strong inhibitory activity against &lt;em&gt;Bacillus subtilis.&lt;/em&gt; C1, C4, C5 showed moderate activity against &lt;em&gt;Escherichia coli,&lt;/em&gt; followed by C2, C3. Meanwhile,&amp;nbsp;&lt;em&gt;Staphylococcus aureus&lt;/em&gt; was less susceptible to pure compounds with low activity of C3, C5. The crude extract and pure compounds displayed biofilm inhibition activity against four pathogenic bacterial strains. &lt;strong&gt;Conclusion: &lt;/strong&gt;Shrimp shell wastes are one of the economic bioproducts used for the production of bioactive secondary metabolites from fungi.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">636</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dina M Eskander&lt;sup&gt;1,&lt;/sup&gt;*, Sherien M.M. Atalla&lt;sup&gt;2&lt;/sup&gt;, Ahmed A. Hamed &lt;sup&gt;3&lt;/sup&gt;, Ezzel -Din A El-Khrisy&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Natural Compounds Department, National Research Centre, Dokki, 12622, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Chemistry of Natural and Microbial Products Dept., Pharmaceutical and Drug Industries Research Div., National Research Centre, Dokki, Giza, P.O. Box: 12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Microbial Chemistry Department, National Research Centre, 33 El-Buhouth Street, P.O. Box 12622, Dokki, Giza, EGYPT&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novia Delita</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Identification of Chemical Compounds from Garcinia fruticosa Lauterb Stem Bark Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">4-hydroxy-3-methoxy benzoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia fruticosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Isolation</style></keyword><keyword><style  face="normal" font="default" size="100%">Stigmasterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Structural elucidation</style></keyword><keyword><style  face="normal" font="default" size="100%">β-sitosterol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1641-1652</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Garcinia is a tropical plant that grows in Indonesia. Garcinia has many health benefits for the body. Garcinia contains many phenolic compounds and their derivatives, such as xanthon, flavonoids, benzophenone, lactone, and phenolic acids. &lt;em&gt;Garcinia fruticosa &lt;/em&gt;Lauterb. comes from the family Clusiaceae. The results of the phytochemical examination showed that &lt;em&gt;G. fruticosa &lt;/em&gt;bark extract contained alkaloids, flavonoids, glycosides, tannins, and saponins.&lt;strong&gt; Objective: &lt;/strong&gt;This study aims to isolate and identify chemical compounds from the ethyl acetate extract of &lt;em&gt;G. fruticosa &lt;/em&gt;Lauterb stem bark.&lt;strong&gt; Method: &lt;/strong&gt;&lt;em&gt;G. fruticosa &lt;/em&gt;Lauterb bark. dried, milled, and extracted with Step Gradient Polarity/SGP maceration using n-hexane, ethyl acetate, and methanol. Isolation was done by column chromatography and identified by thin layer chromatography and IR spectroscopy, LC-MS/MS, &lt;sup&gt;1&lt;/sup&gt;H-NMR, &lt;sup&gt;13&lt;/sup&gt;C-NMR, 2D-NMR (HSQC, HMBC). &lt;strong&gt;Results: &lt;/strong&gt;Compound D7a has a molecular weight 168.0496. The IR spectrum shows the presence of a group –OH appears on 3483 cm&lt;sup&gt;-1&lt;/sup&gt;, aromatic presence in 1609 cm&lt;sup&gt;-1&lt;/sup&gt;. The H-NMR spectrum shows the presence of aromatic signals on 6.96 (d, 8 Hz), 6.96 (d, 2 Hz) and 7.70 (dd, 8; 2 Hz). The C-NMR spectrum shows the presence of a carboxylic-COOH group appearing at 166.57 ppm, the presence of 2 x C-OH appearing at 147.18 and 151.18. In the HMBC spectrum, the -OCH&lt;sub&gt;3&lt;/sub&gt; position is located at C-3 with a correlation between the 3.79 (s) signal and the C signal at the chemical shift 147.18. &lt;strong&gt;Conclusions: &lt;/strong&gt;Structural elucidation shows that compound D7a is a 4-hydroxy-3-methoxy benzoate acid (Vanylic Acid) and isolate I-1 is an impure compound namely β-Sitosterol and Stigmasterol.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1641</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novia Delita&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;3&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;4,5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate Programme of Biology Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. Dr. Hamka, 1340 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences, Serpong, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy, Universitas Pancasila, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Wardatun</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Abdul Mun'im</style></author><author><style face="normal" font="default" size="100%">Fadlina Chany Saputri</style></author><author><style face="normal" font="default" size="100%">Noorwati Sutandyo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Leucaena leucocephala (Lam.) de Wit Seeds: A New Potential Source of Sulfhydryl Compounds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Leucaena leucocephala (Lam.) de Wit</style></keyword><keyword><style  face="normal" font="default" size="100%">Mimosine</style></keyword><keyword><style  face="normal" font="default" size="100%">Sulfhydryl compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">298-302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit seeds are considered the most widely consumed legumes by ruminants. The seeds contain around 1.5 mmol of thiol/sulfhydryl compounds per 100 g of dried seeds. The contents of the sulfhydryl compounds can act like glutathione. On the other hand, the intake of a high amount of &lt;em&gt;Leucaena leucocephala &lt;/em&gt;(Lam.) de Wit seeds is limited by mimosine because it can induce toxicity and death in ruminants.&lt;strong&gt; Objective: &lt;/strong&gt;The aim of this study was to determine sulfhydryl compound levels in &lt;em&gt;Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit seeds after the mimosine removal process. &lt;strong&gt;Materials and methods:&lt;/strong&gt; &lt;em&gt;Leucaena leucocephala&lt;/em&gt; (Lam.) de Wit seeds were soaked in aquadest for 24 hours and then dried at 40°C for 86 hours. The dried seeds were macerated at room temperature using 30%, 50%, 70%, and 96% (v/v) of ethanol as the solvent with a 1:10 solvent-to-solid ratio. Levels of dried extract yield were determined for sulfhydryl compounds and mimosine using a spectrophotometer.&lt;strong&gt; Results: &lt;/strong&gt;The 30% ethanol extract without soaking produced the highest levels of extract yield, but 70% ethanol was the most effective solvent for extracting the maximum sulfhydryl and minimum mimosine levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Ethanol solvent (70%) can be used to extract maximum levels of sulfhydryl compound and minimum levels of mimosine from &lt;em&gt;Leucaena leucocephala &lt;/em&gt;(Lam.) de Wit soaked seeds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">298</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Wardatun&lt;sup&gt;1&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;1,&lt;/sup&gt;*, Abdul Mun'im&lt;sup&gt;2&lt;/sup&gt;, Fadlina Chany Saputri&lt;sup&gt;3&lt;/sup&gt;, Noorwati Sutandyo&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Bioavailability and Bioequivalence, Faculty of Pharmacy, Universitas Indonesia, Depok 16242, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dharmais, Cancer Hospital, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bokov DO</style></author><author><style face="normal" font="default" size="100%">Potanina OG</style></author><author><style face="normal" font="default" size="100%">Nikulin AV</style></author><author><style face="normal" font="default" size="100%">Shchukin VM</style></author><author><style face="normal" font="default" size="100%">Orlova VA</style></author><author><style face="normal" font="default" size="100%">Bagirova GB</style></author><author><style face="normal" font="default" size="100%">Kakhramanova SD</style></author><author><style face="normal" font="default" size="100%">Al- Khafaji H</style></author><author><style face="normal" font="default" size="100%">Balobanova NP</style></author><author><style face="normal" font="default" size="100%">Evgrafov AA</style></author><author><style face="normal" font="default" size="100%">Samylina IA</style></author><author><style face="normal" font="default" size="100%">Krasnyuk II</style></author><author><style face="normal" font="default" size="100%">Golubeva OA</style></author><author><style face="normal" font="default" size="100%">Kuleshova ES</style></author><author><style face="normal" font="default" size="100%">Moiseev DV</style></author><author><style face="normal" font="default" size="100%">Bessonov VV</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Modern Approaches to the Analysis of Kelp (Laminaria sp.) as Pharmacopoeial Herbal Drugs and Food Products</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">alginic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Iodine</style></keyword><keyword><style  face="normal" font="default" size="100%">Kelp</style></keyword><keyword><style  face="normal" font="default" size="100%">Laminaria japonica</style></keyword><keyword><style  face="normal" font="default" size="100%">Laminaria saccharina</style></keyword><keyword><style  face="normal" font="default" size="100%">Laminarin</style></keyword><keyword><style  face="normal" font="default" size="100%">Mannitol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">929-937</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Currently, the chemical composition of&lt;em&gt; Laminaria&lt;/em&gt; J.V. Lamour. species is well studied; they have found applications in the food, cosmeceutical and pharmaceutical industries. The main groups of biologically active compounds are polysaccharides (alginic acid, laminarin, mannitol, fucoidan, and others) and minerals (iodine compounds, magnesium, potassium, calcium, iron) that are determined according to pharmacopoeial and All-Union State Standards requirements.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;For data obtaining various types of search tools and engines such as Google, Google scholar, scientific literature (including Russian sources), normative documentation of Russian Federation (State Pharmacopoeia of Russian Federation IV edition, All-Union State Standards, and others) electronic databases such as e-Library, Scopus, Web of Science, Pubmed were used. &lt;strong&gt;Results:&lt;/strong&gt; In the course of this review study, a modern characteristic of the kelp thallus as a pharmaceutical, cosmeceutical, food substance of plant origin is presented. The data on the chemical composition, harvesting, and processing of raw materials are summarized. The standardization and safety issues of kelp thallus are considered taking into account modern pharmacopoeial and food international requirements. The approaches to the qualitative and quantitative analysis of biologically active compounds (polysaccharides, iodine) and the determination of safety indicators are studied. &lt;strong&gt;Conclusions:&lt;/strong&gt; The regulatory documentation that is used in the quality control of kelp needs to be finalized and updated. For pharmacopoeial analysis, all possible physicochemical methods (gravimetric, titrimetric, spectrophotometric) should be presented in the newly approved monograph. In this case, modern procedures should be developed, including HPLC with various types of detection (determination of the carbohydrates profile and polysaccharides, including methods with acid and enzyme hydrolysis). This will ensure the required level of quality, the safety of kelp (Laminaria) raw materials.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">929</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bokov DO&lt;sup&gt;1,2,&lt;/sup&gt;*, Potanina OG&lt;sup&gt;3&lt;/sup&gt;, Nikulin AV&lt;sup&gt;3&lt;/sup&gt;, Shchukin VM&lt;sup&gt;4&lt;/sup&gt;, Orlova VA&lt;sup&gt;1&lt;/sup&gt;, Bagirova GB&lt;sup&gt;1&lt;/sup&gt;, Kakhramanova SD&lt;sup&gt;1,4&lt;/sup&gt;, Al-Khafaji H&lt;sup&gt;1&lt;/sup&gt;, Balobanova NP&lt;sup&gt;1&lt;/sup&gt;, Evgrafov AA&lt;sup&gt;1&lt;/sup&gt;, Samylina IA&lt;sup&gt;1&lt;/sup&gt;, Krasnyuk II&lt;sup&gt;1&lt;/sup&gt; (junior), Golubeva OA&lt;sup&gt;5&lt;/sup&gt;, Kuleshova ES&lt;sup&gt;6&lt;/sup&gt;, Moiseev DV&lt;sup&gt;7&lt;/sup&gt;, Bessonov VV&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Sechenov First Moscow State Medical University, 8 Trubetskaya St., bldg. 2, Moscow, 119991, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Рeoples’ Friendship University of Russia (RUDN University), 6, Miklukho-Maklaya Street, Moscow, 117198, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products”, 8/2 Petrovsky Boulevard, Moscow, 127051, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Murmansk State Technical University, 183010, str. Sportivnaya, 13, Murmansk, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Orel State University named after I.S. Turgenev, 95 Komsomolskaya st., Orel region, Orel, 302026, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Vitebsk State Medical University, 27, Frunze avenue, Vitebsk, 210062, BELARUS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Endang Hanani</style></author><author><style face="normal" font="default" size="100%">Vivi Anggia</style></author><author><style face="normal" font="default" size="100%">Ike Nurvita Amalina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ochna kirkii Oliv: Pharmacognostical Evaluation, Phytochemical Screening, and Total Phenolic Content</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromatogram profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Ochna kirkii</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1317-1324</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Ochna kirkii &lt;/em&gt;Oliv. belongs to family Ochnaceae is commonly known as “mickey mouse plants” in Asia, included in Jakarta. &lt;strong&gt;Objectives:&lt;/strong&gt; This research was conducted to study the pharmacognosy and total phenolic content. &lt;strong&gt;Methods: &lt;/strong&gt;The pharmacognosy study including the macroscopic, microscopic, fluorescence and phytochemical characteristic, which enable to identification of medicinal plant drug, as well as the total phenolic content using spectrophotometric method. Physicochemical parameters, like loss on drying, ash value, extractive values etc. were also determined following WHO guidelines. &lt;strong&gt;Results: &lt;/strong&gt;Physicochemical standard quantified include total ash 5.15% ± 0.4623, acid insoluble ash 0.32% ± 0.2614, water soluble ash 10.72% ± 0.2340, alcohol soluble extractive 12.8% ± 1.3770, ether soluble extractive 7.30% ± 1.8341, water content 5.76 % ± 0.0050, loss on drying 6.91% ± 1.6133. Preliminary phytochemical screening of the leaves showed the presence of flavonoids, tannins, phenols, saponins and triterpenoid. TLC profile of the &lt;em&gt;O.kirkii&lt;/em&gt; leaves extracts (n-hexane, DCM, ethyl acetate and 70% ethanol) showed 8, 6, 7 and 10 spots respectively; in different solvent system. The total phenolic content was 252.08 mg GAE/g± 0.4430. &lt;strong&gt;Conclusions:&lt;/strong&gt; The various macroscopic, microscopic, physical and phytochemical analysis of the &lt;em&gt;O.kirkii &lt;/em&gt;leaf is useful in standardization for quality, purity and sample identification.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1317</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Endang Hanani*, Vivi Anggia, Ike Nurvita Amalina &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. HAMKA Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vishnu Priya Veeraraghavan</style></author><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Janardhana Papayya Balakrishna</style></author><author><style face="normal" font="default" size="100%">Surapaneni Krishna Mohan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Paronychia argentea: A Critical Comprehensive Review on its Diverse Medicinal Potential and Future as Therapeutics</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-microbial</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactivity</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Paronychia argentea</style></keyword><keyword><style  face="normal" font="default" size="100%">Therapeutic value</style></keyword><keyword><style  face="normal" font="default" size="100%">Ulcerative colitis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1172-1179</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Paronychia argentea&lt;/em&gt; has been used since long as a traditional medicine for the treatment of diabetes, kidney stones, anti-microbial and many other human diseases. However, the plant has not been explored much. In the present scenario of drug resistance and toxicity associated with available drugs, there is a need for elaborated studies of plants like &lt;em&gt;Paronychia argeneta&lt;/em&gt; which had been used as folk medicines. &lt;strong&gt;Aim and Objectives:&lt;/strong&gt; The present article is focused on reviewing the ethnopharmacology, phytochemistry, traditional usage, biological activities, of &lt;em&gt;Paronychia argentea&lt;/em&gt; which has been used in traditional medicinal system for ages. The aim of the study was to assess the ethnopharmacological usage of this plant and to explore therapeutic potentials and future opportunities for research. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Information on the traditional usage and studies of the &lt;em&gt;Paronychia argentea&lt;/em&gt; was gathered from from various journals, MSc dissertation, conference abstract, local books. Various search engines including Google Scholar, Baidu Scholar, Elsevier, ACS, Pubmed, Web of Science, CNKI and EMBASE were used to collect the information along with libraries. &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Paronychia argentea&lt;/em&gt; has played an important role in traditional medicines in Algeria, Portugal, Israel and Jordan. The aerial parts of this plant are used as diuretics in Algerian traditional medicines and are used as antiurolithiasis. Leaf decoction of this plant is also used as diuretic. &lt;em&gt;Paronychia argentea&lt;/em&gt; has been used as analgesic, treatment of stomach ulcer, anorexia, and flatulence in Portugal. Scientific studies on extracts of &lt;em&gt;Paronychia&lt;/em&gt; revealed a wide range of pharmacological activities including anti-microbial activity, anti-oxidant, nephroprotective activity. Moreover, few reports have given contradictory data for usage of &lt;em&gt;Paronychia &lt;/em&gt;when compared with its traditional usage. As in the case of alpha-amylase inhibitory efficacy of PA, it was observed that PA inhibits alpha-amylase activity but later on it was proven that PA does not have a hypoglycemic effect. Main bioactive metabolites present in this plant include alkaloids, flavonoids, volatile oils, etc. &lt;strong&gt;Conclusions:&lt;/strong&gt; Based on this review, there are evidences from various studies regarding pharmacological effects of this plant as nephroprotective, anti-oxidant, anti-microbial activity. Some indications from &lt;em&gt;in vitro &lt;/em&gt;studies have confirmed the inhibitory activity of this plant extract against alpha amylase enzyme. The available literature showed that most of the activities of the &lt;em&gt;Paronychia&lt;/em&gt; can be accredited to the flavonoids present in them. Data regarding mechanisms of action of this plant along with pharmacokinetics, toxicology studies is still limited, which indicate the need of such studies for the clinical usage of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1172</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vishnu Priya Veeraraghavan&lt;sup&gt;1,&lt;/sup&gt;*, Sardar Hussain&lt;sup&gt;2&lt;/sup&gt;, Janardhana Papayya Balakrishna&lt;sup&gt;3&lt;/sup&gt;, Surapaneni Krishna Mohan&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Saveetha Dental College &amp;amp; Hospital, Saveetha Institute of Medical &amp;amp; Technical Sciences (SIMATS), Saveetha University, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Government Science College, Chitradurga-577501, , Karnataka, India&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Stem Cell Biology, Stellixir Biotech Pvt Ltd, No.V-31, 2nd floor, 10th Main Road, Peenya 2nd Stage Industrial Area, Bangalore - 560058, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Panimalar Medical College Hospital &amp;amp; Research Institute, Varadharajapuram, Poonamallee, Chennai – 600 123, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Dhanalakshmi</style></author><author><style face="normal" font="default" size="100%">N Harikrishnan</style></author><author><style face="normal" font="default" size="100%">N Srinivasan</style></author><author><style face="normal" font="default" size="100%">P Pandian</style></author><author><style face="normal" font="default" size="100%">BA Tanisha</style></author><author><style face="normal" font="default" size="100%">M Tharun Kumar</style></author><author><style face="normal" font="default" size="100%">V Lokesh</style></author><author><style face="normal" font="default" size="100%">N Yuvashri</style></author><author><style face="normal" font="default" size="100%">S Supriya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Perspective Overview on Hygrophila auriculata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hygrophila auriculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1748-1752</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Hygrophila auriculata, &lt;/em&gt;belonging to the family Acanthaceae, is a promising medicinal plant with great economic potential. The medicinal value of &lt;em&gt;H. auriculata&lt;/em&gt; has been appreciated in the ancient medical literature. The plant contains terpenoids, alkaloids, flavonoids, and is traditionally known as an aphrodisiac, renal tonic, and for its health-promoting properties. The plant is cultivated throughout India. However, systematic information on the different aspects of this species is not available. In this review, an attempt has been made to present this information.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1748</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;S Dhanalakshmi&lt;sup&gt;1,&lt;/sup&gt;*, N Harikrishnan&lt;sup&gt;2&lt;/sup&gt;, N Srinivasan&lt;sup&gt;3&lt;/sup&gt;, P Pandian&lt;sup&gt;4&lt;/sup&gt;, BA Tanisha&lt;sup&gt;5&lt;/sup&gt;, M Tharun Kumar&lt;sup&gt;5&lt;/sup&gt;, V Lokesh&lt;sup&gt;5&lt;/sup&gt;, N Yuvashri&lt;sup&gt;5&lt;/sup&gt;, S Supriya&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ),Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry &amp;amp; Analysis, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ),Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacognosy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar, Chidambaram, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pharma buddy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute (Deemed to be Univ), Velappanchavadi, Chennai – 600 077, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurlina Ibrahim</style></author><author><style face="normal" font="default" size="100%">Siti Nuryanti</style></author><author><style face="normal" font="default" size="100%">Asriani Hasanuddin</style></author><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Antihyperuricemic Activity of Ethanolic Extract of Moringa oleifera Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihyperuricemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthin Oxidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1698-1704</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is a popular plant that has been known to have several importance biological activities.&lt;strong&gt; Objectives: &lt;/strong&gt;To perform phytochemical analysis, to in vivo evaluate the antihyperuricemic activity and to measure the inhibition of ethanolic extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; seed on xanthine oxidase enzyme.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The seed were collected from Sigi regency, Central Sulawesi, Indonesia. Extraction was performed by maceration method with ethanol 96% as a solvent. Thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and spectrophotometric UV-Vis were used to determine the phytochemical contents. The antihyperuricemic activity was evaluated by using in vivo model of rat induced by potassium oxonate. The xanthin oxidase inhibitory activity was also determined by spectroscopic method by measuring the catalytic rate of xanthin oxidase enzyme. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis confirmed the presence of alkaloids, terpenoids, flavonoids, phenolics, saponin and tannin. Quantitative determination of total flavonoids and quercetin concentration found the values of 82.17 ± 0.684 mg QE/g and 0.5131 ± 0.0022 mg/g dried extract, respectively. Ethanolic extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; seed have potential antihyperuricemic activity in which it can significantly reduce the serum uric acid level on potassium oxonate-induced hyperuricemic rat model with the effective dose of 125 mg/ kg BW. Xanthin oxidase inhibitory activity showed the moderate activity with IC&lt;sub&gt;50 &lt;/sub&gt;of 88.39 μg/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study confirmed the potential of&lt;em&gt; Moringa oleifera&lt;/em&gt; seed ethanolic extract, growing in Sigi, Central Sulawesi to be developed as herbal medicinal source for antihyperuricemic drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1698</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurlina Ibrahim&lt;sup&gt;1&lt;/sup&gt;, Siti Nuryanti&lt;sup&gt;2&lt;/sup&gt;, Asriani Hasanuddin&lt;sup&gt;3&lt;/sup&gt;, Muhammad Sulaiman Zubair&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Sciences, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Teacher Training and Education, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Husbandry, Faculty of Animal Husbandry and Fisheries, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitri Santy Budiarso</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Roshamur Cahyan Forestrania</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential of Stem Bark of Kayu Sarampa (Xylocarpus moluccensis (Lam.) M. Roen)) as α-glucosidase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Kayu Sarampa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1368-1376</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The prevalence of diabetes mellitus type 2 in the world is more than 230 million people, increases about 3% in a year. Kayu Sarampa or Nyirih batu (&lt;em&gt;Xylocarpus moluccensis&lt;/em&gt; (Lam.) M. Roen) has traditionally been used to treat diabetic patient by native people in Ratahan, North Celebes, Indonesia. Therefore, this research was sequentially extracted bioactive component from stem bark of kayu sarampa showed alpha glucosidase inhibitor. &lt;strong&gt;Objective:&lt;/strong&gt; To assess antioxidants and alpha glucosidase inhibitory activity of hexane, ethyl acetate, and methanol extract from stem bark of Kayu Sarampa. &lt;strong&gt;Method:&lt;/strong&gt; The Stem bark was extracted with Reflux method using hexane, ethyl acetate, and methanol as mobile phae/solvent. The Hexane Extract (HE), Ethyl Acetic Extract (EAE) and Methanol Extract (ME) were subjected to the antioxidant activity assay by the 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and the ferric-reducing antioxidant power (FRAP) method. Antidiabetic activity was determined by enzymatic alpha-glucosidase inhibitor. &lt;strong&gt;Results:&lt;/strong&gt; The extract which had the highest activity based on the DPPH test and FRAP test was the ME compared with EAE, and HE with IC50 values of 16.51 μg/mL, 34.10 51 μg/mL, and 38.82 51 μg/mL , respectively. Ferrous equivalent antioxidant capacity (FeEAC) method, methanolic extract had a higher reduction capacity than the EH and EEA which were 148.96 μmol/gr, 48.96 μmol/gr, and 148.96 μmol/gr, respectively. The result showed that kayu sarampa stem bark exhibited antidiabetic activity due to its high inhibition compared with control (acarbose). ME showed inhibition of 53,11% followed with EAE 49,7%, HE 44,53%, and acarbose as control 29,32%.Conclusion: stem bark of kayu sarampa have bioactive component as alpha glucosidase inhibitor&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1368</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitri Santy Budiarso&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Roshamur Cahyan Forestrania&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Institute of Sciences and Faculty of Pharmacy, University of Pancasila, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Joni Tandi</style></author><author><style face="normal" font="default" size="100%">I Nyoman Edi Sutrisna</style></author><author><style face="normal" font="default" size="100%">Mentari Pratiwi</style></author><author><style face="normal" font="default" size="100%">Tien Wahyu Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Test of Nephropathy Sonchus arvensis L. Leaves on Male Rats (Rattus norvegicus) Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf Sonchus arvensis L</style></keyword><keyword><style  face="normal" font="default" size="100%">Renal</style></keyword><keyword><style  face="normal" font="default" size="100%">Tubular</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1115-1120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to determine the type of secondary metabolites compounds of the ethanol&lt;em&gt; Sonchus arvensis&amp;nbsp;&lt;/em&gt;L leaves extract, the effect of ethanol &lt;em&gt;Sonchus arvensis&lt;/em&gt; L leaves extracts the levels of blood glucose and a histopathology picture male white rat induced by streptozotocin. This study used 30 males white rats which were divided into 6 groups, namely the control of normal, negative control, positive control, doses of 200, 300 and 400 mg/kg BW. Results of the study showed that the ethanol &lt;em&gt;Sonchus arvensis&lt;/em&gt; L. leaves extracts contained compounds of alkaloids, flavonoids, phenols, saponins and tannins. &lt;em&gt;Sonchus arvensis&lt;/em&gt; L ethanol extract at a dose of 300 mg/kg BW is an effective dose in reducing blood glucose levels with an average value of decreasing blood glucose levels 101.6 mg / dL and has an effect on the regeneration of renal tubular cells with an effective dose is 300 mg / kg body weight with an average damage value of 0.28.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1115</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Joni Tandi*, I Nyoman Edi Sutrisna, Mentari Pratiwi, Tien Wahyu Handayani &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;College of pharmaceutical sciences Pelita Mas Palu, Central Sulawesi 94111, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maha A Fahmy</style></author><author><style face="normal" font="default" size="100%">Entesar E Hassan</style></author><author><style face="normal" font="default" size="100%">Noha E Ibrahim</style></author><author><style face="normal" font="default" size="100%">Emad M Hassan</style></author><author><style face="normal" font="default" size="100%">Zeinab M Hassan</style></author><author><style face="normal" font="default" size="100%">Enayat A Omara</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone marrow</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Fig</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">645-656 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present work investigated the protective effect of &lt;em&gt;Ficus carica&lt;/em&gt; (common fig) leaves methanol extract against genotoxicity and testicular damage of cisplatin (CP) and identified some of its active ingredients. &lt;strong&gt;Methods: &lt;/strong&gt;Seven main groups were investigated as follows: I. control negative, II. Control plant (600 mg/kg fig, orally), III, IV. Control positive (treated i.p with 10 and 15 mg/kg CP), V-VII. groups treated with fig (200, 400 and 600 mg/ kg) + Cisplatin (15 mg/kg). &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Ficus carica&lt;/em&gt; alleviated the destructive effects of CP in the testis, liver and bone marrow due to the presence of high amount of flavonoids and phenolic compounds. Also it has a normal effect in the tested parameters as compared with the control negative. Chromatographic investigation resulted in the identification of 6 compounds: Catechin, Luteolin-8-C-β-D glucopyranoside, Quercetin, Quercetin-3-O-β-d-glucopyranoside, Chlorogenic acid and Kaempferol-3-O-β-D-glucopyranoside. In bone marrow cisplatin induced significant percentage of chromosome abnormalities, micronuclei in polychromatic erythrocytes and toxicity to cells. On the contrary the two tested doses of cisplatin had a normal effect on spermatocyte chromosomes (germ cells). The dose 15 mg/kg induced an overexpression of the liver genes NF-kB and iNOS as indicated by real-time PCR. Different forms of histopathological alterations and instigation of the expression of TNF-α gene in the testis were detected after CP treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Ficus carica&lt;/em&gt; is a promising candidate rich in many bioactive constituents and can be used in combination with chemotherapeutic drugs to alleviate their destructive effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">645</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maha A. Fahmy&lt;sup&gt;1&lt;/sup&gt;, Entesar E. Hassan&lt;sup&gt;1,&lt;/sup&gt;*, Noha E. Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Emad M. Hassan&lt;sup&gt;3&lt;/sup&gt;, Zeinab M. Hassan&lt;sup&gt;4&lt;/sup&gt;, Enayat A. Omara&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Genetics and Cytology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medicinal and Aromatic Plants Research Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Natural Compounds Chemistry Department, National Research Centre,Dokki, Cairo, EGYPT&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pathology Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Friardi Ismed</style></author><author><style face="normal" font="default" size="100%">Dony Afriyandi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization Study of Simplicia and Extract of Calamondin (Citrus microcarpa Bunge) Peel, Quantification of Hesperidin and Antibacterial Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Citrus microcarpa Bunge</style></keyword><keyword><style  face="normal" font="default" size="100%">Hesperidin</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">777-783</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Calamondin (&lt;em&gt;Citrus microcarpa &lt;/em&gt;Bunge) is a commodity which is widely grown in Indonesia, including in western Sumatera. &lt;strong&gt;Aim: &lt;/strong&gt;This study was conducted to Standardization Study of Simplicia and Extract of Calamondin (&lt;em&gt;Citrus microcarpa&lt;/em&gt; Bunge) Peel, Quantification of Hesperidin and Antibacterial Assay. &lt;strong&gt;Materials&amp;nbsp;and Methods:&lt;/strong&gt; The semi-solid extract of Calamondin peel was made by the maceration method using 70% ethanol solvent. Then standardization study chamomile extract (Organoleptic examination of extracts, Chromatographic analysis, Total Ash, Acid-insoluble ash, Water content), quantification of hesperidin by TLC-densitometry method and antibacterial activity assay for diffusion method. The antibacterial activity of extracts against &lt;em&gt;Staphylococcus aureus, Escherichia coli, Enterococcus faecalis&amp;nbsp;&lt;/em&gt;and &lt;em&gt;Pseudomonas aeruginous. &lt;/em&gt;&lt;strong&gt;Results: &lt;/strong&gt;The organoleptic properties of the calamondin peel showed that the outer surface was brown and the inside was yellow, slightly smelly and sour taste. Microscopic characterizations obtained identifiers of calcium oxalate crystal fragments, fibers, parenchyma with oil cells, ladder-shaped transport tissue. Water and alcohol-soluble extractive are not less than 19.73% ± 0.97% and 10.26% ± 0.25%, loss on drying is not more than 10.78% ± 0.05% and the total and acidinsoluble ash is not more than 4.33% ± 0.03% and 1.01% ± 0.07%. The calamondin peel extract is described in the form of thick extract, a specific smell, a black color, bitter taste and yield not less than 25.33% ± 1.3%. Quantification of hesperidin obtained not less than 4.78% ± 0.09%, a water content of no more than 17.47% ± 0.82% and the total ash content and acid insoluble ash are not more than 4.65% ± 0.06% and 0.13% ± 0.04%. Antibacterial activity of extracts against &lt;em&gt;Staphylococcus aureus, Escherichia coli, Enterococcus faecalis&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginous &lt;/em&gt;at 15% concentration with inhibitory diameter range of 7.65 mm ± 0.36 mm to 9.96 mm ± 0.52 mm and at a concentration of 20% with inhibitory diameter ranges of 9.26 mm ± 0.72 mm to 13.39 mm ± 0.28 mm. &lt;strong&gt;Conclusion: &lt;/strong&gt;Calamondin (&lt;em&gt;Citrus microcarpa&lt;/em&gt; Bunge) peel have antioxidant and antibacterial activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">777</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Friardi Ismed, Dony Afriyandi&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Friday Super Nova</style></author><author><style face="normal" font="default" size="100%">Shofa Chasani</style></author><author><style face="normal" font="default" size="100%">Atina Hussanna</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tender Coconut Water Inhibits the Process of Lipid Peroxidation, Reduce Glucose Levels and Increase Plasma Insulin in Pregnant Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GDM</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin plasma</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Tender coconut water (TCW)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">162-167</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Diabetes during pregnancy or Gestational Diabetes Mellitus&lt;em&gt; &lt;/em&gt;(GDM) causes oxidative stress and have bad effect for mother and baby, risk of abortion, still birth, premature and preeclampsia. GDM can be prevented by monitoring the glucose level and providing rich antioxidants meals. TCW is a nutritious healthy drink rich in antioxidants, diet rich in antioxidants promotes better health, Inhibits lipid peroxidation and enhances the total antioxidant status. &lt;strong&gt;Aim and Objectives: &lt;/strong&gt;This research to investigate the effect of tender coconut water can prevent lipid peroxidation, reduce glucose levels and increase insulin plasma level on pregnant diabetic rats. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Experimental study by post test only control group design, population of pregnant wistar strain rats. Twenty four samples used in this study were randomly divided into 4 groups, K1 (pregnant rats), K2 (pregnant rats+diabetic), K3 (pregnant rats+diabetic+ glibenklamid 0.23 mg/kg BW ) and K4 (pregnant rats+diabetic+TCW 8mL/200grBW). Diabetes Mellitus were induced using Streptozotocin (STZ) 65mg/kgBW and Nicotinamid 230 mg/kgBW. Data on insulin plasma, glucose and MDA levels were analyzed using One Way Anova with significant level 0.05.&lt;strong&gt; Result: &lt;/strong&gt;The results showed that the average insulin plasma levels in group 2 decreased compared to group 1 , in group 3 and 4 it increased compared to group 2. Average glucose and MDA levels in group 2 increased compared to group 1 , in group 3 and 4 it decreased compared to group 2. The results of the analysis has the p values 0.000 (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&amp;nbsp;&lt;/strong&gt;TCW can inhibit the process of lipid peroxidation, reduce glucose levels, increase insulin plasma levels and in pregnant diabetic rats.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">162</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Friday Super Nova&lt;sup&gt;1&lt;/sup&gt;, Shofa Chasani&lt;sup&gt;2&lt;/sup&gt;, Atina Hussanna&lt;sup&gt;2&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student Program Master of Biomedical Science Faculty of Medicine Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturers Program Master of Biomedical Science Faculty of Medicine Sultan Agung Islamic University, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kartini Kartini</style></author><author><style face="normal" font="default" size="100%">Ervina Rustiana Dewi</style></author><author><style face="normal" font="default" size="100%">Fandi Achmad</style></author><author><style face="normal" font="default" size="100%">Nikmatul Ikhrom Eka Jayani</style></author><author><style face="normal" font="default" size="100%">Mochammad Arbi Hadiyat</style></author><author><style face="normal" font="default" size="100%">Christina Avanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Thin Layer Chromatography Fingerprinting and Clustering of Orthosiphon stamineus Benth. from Different Origins</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Geographical origin</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Marker</style></keyword><keyword><style  face="normal" font="default" size="100%">Principal Component Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">79-87</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Orthosiphon stamineus&lt;/em&gt; has been widely used across Asian countries for the treatment of various diseases. The quality of herbal medicine determine its safety as well as efficacy; and geographical origin is important factor contributing on the quality of herb and its products. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Thin Layer Chromatography (TLC) method combined with chemometric, Principal Component Analysis (PCA), has been employed to evaluate the quality of &lt;em&gt;Orthosiphon stamineus&lt;/em&gt; leaves collected from eleven origins in Indonesia.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that mobile phase suitable for &lt;em&gt;Orthosiphon stamineus&lt;/em&gt; was chloroform, dichloromethane, ethyl acetate (7:4:1). The method used has met the requirements of TLC system stability and precision. TLC-fingerprints analyzed with chemometrics showed an ability to discriminate &lt;em&gt;Orthosiphon stamineus&lt;/em&gt; from various origins. PCA score plot of the first two principal components (PC) clearly distinguished 3 clusters of samples, whereas the loading plot of the first two PC showed that compounds with the Rf values of 0.0-0.1, 0.1-0.2, 0.2-0.3, and 0.9-1.0 are the most important compounds for clustering of samples. &lt;strong&gt;Conclusions:&lt;/strong&gt; TLCfingerprint combined with the PCA was able to discriminate among the leaves of &lt;em&gt;Orthosiphon stamineus&lt;/em&gt; originated from various locations. TLC-fingerprints analyzed with chemometrics can be used as an alternative of marker-oriented method to evaluate the quality of &lt;em&gt;Orthosiphon stamineus.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">79</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kartini Kartini&lt;sup&gt;1,&lt;/sup&gt;*, Ervina Rustiana Dewi&lt;sup&gt;1&lt;/sup&gt;, Fandi Achmad&lt;sup&gt;1&lt;/sup&gt;, Nikmatul Ikhrom Eka Jayani&lt;sup&gt;1&lt;/sup&gt;, Mochammad Arbi Hadiyat&lt;sup&gt;2&lt;/sup&gt;, Christina Avanti&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Raya Kalirungkut Road, Surabaya 60293, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Industrial Engineering, Faculty of Engineering, University of Surabaya, Raya Kalirungkut Road, Surabaya 60293, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutic, Faculty of Pharmacy, University of Surabaya, Raya Kalirungkut Road, Surabaya 60293, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Salman</style></author><author><style face="normal" font="default" size="100%">Amalia Refina Pratiwi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Topical Anti-Inflammatory Activity of Bromelain</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bromelain</style></keyword><keyword><style  face="normal" font="default" size="100%">Exudate</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Granuloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1586-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Bromelain is a proteolytic enzyme found in pineapple plants. &lt;strong&gt;Aim:&lt;/strong&gt; This study conducted to determine the activity of bromelain enzyme as an anti-inflammatory using the Granuloma Pouch method. &lt;strong&gt;Methods: &lt;/strong&gt;The experimental animals were divided into five groups, namely the positive control group, the bromelain concentration group of 0.1%; 0.5%; 1%, and the comparison group. Experimental animals induced carrageenan 2% subcutaneously. The dosage form is given topically for 2, 4, and 6 days. The observation was made by measuring the volume of edema, the total number, and the percentage of leukocyte cells on days 2, 4, and 6. &lt;strong&gt;Results:&lt;/strong&gt; The observation results of a positive control group, bromelain concentration 0.1%, 0.5%, 1%, and the comparators, there was a significant decrease for the volume of exudate on days 2, 4, and 6 (p&amp;lt;0.05). The average total number of leukocytes also decreased significantly (p&amp;lt;0.05) in the positive control, the bromelain, and comparison group in day 2, 4, and 6. At the same time, the mean leucocyte percentage had no effect (p&amp;gt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;From the results of the study, it was concluded that the bromelain enzyme at concentration 0.1%, 0.5%, and 1% have an anti-inflammatory effect by suppressing the volume of exudate, and the total number of leucocyte.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1586</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elsa Badriyya, Salman, Amalia Refina Pratiwi, Dwisari Dillasamola, Yufri Aldi, Elidahanum Husni* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ni Putu Ermi Hikmawanti</style></author><author><style face="normal" font="default" size="100%">Endang Hanani</style></author><author><style face="normal" font="default" size="100%">Yuni Sapitri</style></author><author><style face="normal" font="default" size="100%">Wulan Ningrum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenolic Content and Antioxidant Activity of Different Extracts of Cordia sebestena L. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Boraginaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia sebestena</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Folin-Ciocalteu</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1311-1316</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Cordia sebestena&lt;/em&gt; L. (Boraginaceae) wildly planted in Jakarta, Indonesia. The secondary metabolites of plants have biological and pharmacological activities, such as antioxidant. The antioxidant activity of plants might be due to their phenolic compounds.&lt;strong&gt; Objective: &lt;/strong&gt;To determine the total phenolic content and evaluate the antioxidant activity of&lt;em&gt; C. sebestena &lt;/em&gt;leaves extracts (n-hexane, dichloromethane, ethyl acetate, and 70% ethanol). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The total phenolic content was determined using spectrophotometric methods with a Folin-Ciocalteu reagent. The antioxidant activity of the extracts was determined by its ability to inhibit DPPH radicals through IC&lt;sub&gt;50 &lt;/sub&gt;values (ppm).&lt;strong&gt; Results: &lt;/strong&gt;The highest total phenolic content (167.61 ± 0.56 mg GAE/g) and best antioxidant activity (31.41 ppm) were found in 70% ethanol extract of &lt;em&gt;C. sebestena&lt;/em&gt; compared to other extracts (ethyl acetate &amp;gt; dichloromethane &amp;gt; n-hexane). &lt;strong&gt;Conclusion: &lt;/strong&gt;The &lt;em&gt;C. sebestena&lt;/em&gt; leaves have a good potential as a source of natural antioxidant, and further research, is recommended to evaluate the antioxidant activity using another method.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1311</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ni Putu Ermi Hikmawanti&lt;sup&gt;1,2&lt;/sup&gt;, Endang Hanani&lt;sup&gt;1,2,&lt;/sup&gt;*, Yuni Sapitri&lt;sup&gt;2&lt;/sup&gt;, Wulan Ningrum&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Universitas Muhammadiyah Prof. DR. HAMKA Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. HAMKA Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Huynh Tan Hoi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vietnamese Medicinal Plants Useful in Treatments of Gout</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gout</style></keyword><keyword><style  face="normal" font="default" size="100%">Health</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1693-1697</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Gout is a metabolic pathology associated with an increase in the concentration of uric acid in the blood, characterized by episodes of acute arthritis or chronic arthritis caused by deposition of mononatri urate crystals in joints and connective tissue. Long ago, gout was considered a rare disease and a disease of the rich. Since the early years of the 21&lt;sup&gt;st&lt;/sup&gt; century, the incidence of gout and increased uric acid is increasing rapidly around the world. Clinical manifestations of the disease, the age and gender of the patient, related diseases, response to treatment, adverse consequences of the disease, its association with cardiovascular disease, kidney disease, etc. There are many changes in the negative direction that make the disease become incurable in many patients. Even in developed countries, the disease is not managed and monitored closely, increasing the rate of illness, death, disability and quality of life. The article focuses on the causes, manifestations of gout and, most importantly, the introduction of some herbs used in Vietnam. The scientific components, its effective effects have been confirmed by some documents and trusted by patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1693</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Huynh Tan Hoi*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Language Lecturer, FPT University, VIETNAM.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zulhabri Othman</style></author><author><style face="normal" font="default" size="100%">Hamimi Rasyiqah Hassan Khalep</style></author><author><style face="normal" font="default" size="100%">Azrina Zainal Abidin</style></author><author><style face="normal" font="default" size="100%">Halijah Hassan</style></author><author><style face="normal" font="default" size="100%">Santosh Fattepur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Chicken Chorioallantoic Membrane (CAM) assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia. L leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">White Leghorn eggs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">12-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use &lt;em&gt;Morinda citrifolis.&lt;/em&gt; L extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25%, 50% and 75% of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. &lt;strong&gt;Results:&lt;/strong&gt; Analysis have shown significant differences (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75% extracts showed 37.1% reductions of blood vessel compared to groups 50% and 25% extracts which showed 4% and 12.8% respectively. The phytochemical screening has showed that &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts was positive for flavonoid, phenols and phytosterols. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">12</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Zulhabri Othman&lt;sup&gt;1,2*&lt;/sup&gt;, Hamimi Rasyiqah Hassan Khalep&lt;sup&gt;1&lt;/sup&gt;, Azrina Zainal Abidin&lt;sup&gt;1&lt;/sup&gt;, Halijah Hassan&lt;sup&gt;1&lt;/sup&gt;, Santosh Fattepur&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Graduate Studies, Post-Graduate Centre, Management and Science University, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Andi Hamdillah</style></author><author><style face="normal" font="default" size="100%">Alim Isnansetyo</style></author><author><style face="normal" font="default" size="100%">Indah Istiqomah</style></author><author><style face="normal" font="default" size="100%">Indun Dewi Puspita</style></author><author><style face="normal" font="default" size="100%">Desy Putri Handayani</style></author><author><style face="normal" font="default" size="100%">Takushi Kaneko</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activity of Coastal Plants and Marine Sponges from Kei Island Indonesia against Bacterial Fish Pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Coastal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Fish pathogen</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine sponge</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolite</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">812-817</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The objective of this study was to investigate the antibacterial activity of coastal plants and marine sponges extracts against fish bacterial pathogens. &lt;strong&gt;Methods:&lt;/strong&gt; Samples were extracted by maceration and the extracts were examined for their antibacterial activities against &lt;em&gt;Streptococcus&lt;/em&gt; sp. BJ0509, &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC 6538,&lt;em&gt; Aeromonas hydrophila&lt;/em&gt; BA03 and &lt;em&gt;Vibrio parahaemolyticus&lt;/em&gt; 29S by means of paper disc diffusion method. Active extracts were partitioned and purified by column chromatography. The purified substance was tested for Minimum Inhibitory Concentration (MIC) against seven bacterial fish pathogens namely&lt;em&gt; Streptococcus &lt;/em&gt;sp., &lt;em&gt;Vibrio parahaemolyticus&lt;/em&gt;, &lt;em&gt;V. alginolyticus, V. harveyi, Photobacterium damselae, Aeromonas hydrophila and A. dhakensis.&lt;/em&gt; &lt;strong&gt;Results: &lt;/strong&gt;The highest antibacterial activity against all bacteria used in the assay was demonstrated by OKA 6, a bark extract sample of a coastal plant, &lt;em&gt;Diospyros maritima.&lt;/em&gt; It showed a diameter of inhibition zones against &lt;em&gt;Streptococcus &lt;/em&gt;sp. BJ0509, &lt;em&gt;S. aureus&lt;/em&gt; ATCC 6538, &lt;em&gt;A. hydrophila&lt;/em&gt; BA03 and &lt;em&gt;V. parahaemolyticus&lt;/em&gt; 29S of 19, 33, 18, and 18 mm, respectively. The column chromatography fraction of OKA 6 inhibited the growth of &lt;em&gt;S. aureus&lt;/em&gt; ATCC 6538 with MIC of 3.125 μg/mL. The MIC of this fraction against seven bacterial fish pathogens ranged &amp;lt; 0.098 to 3.125 μg/mL. The antibacterial activity of partially purified substance obtained from column chromatography fractionation of OKA 6 was higher than those of oxytetracycline and kanamycin. &lt;strong&gt;Conclusions: &lt;/strong&gt;This result indicates that antibacterial activity of the partially purified substance is potentially higher than those of the commercial antibiotics tested. It further indicates that OKA 6 extract from &lt;em&gt;D. maritima&lt;/em&gt; can serve as a promising resource for the development of therapeutic agents against bacterial infections in aquaculture.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">812</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Andi Hamdillah&lt;sup&gt;1&lt;/sup&gt;, Alim Isnansetyo&lt;sup&gt;1,*&lt;/sup&gt;, Indah Istiqomah&lt;sup&gt;1&lt;/sup&gt;, Indun Dewi Puspita&lt;sup&gt;1&lt;/sup&gt;, Desy Putri Handayani&lt;sup&gt;1&lt;/sup&gt;, Takushi Kaneko&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada, Jl. Flora, Bulaksumur, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Global Alliance for TB Drug Development, Research and Development, 40 Wall Street, 24&lt;sup&gt;th&lt;/sup&gt; Floor, New York, NY, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marcos Ignacio Jimenez Zuniga</style></author><author><style face="normal" font="default" size="100%">Alejandro Jonathan Hurtado Mariles</style></author><author><style face="normal" font="default" size="100%">Jose Luis Castrejon Flores</style></author><author><style face="normal" font="default" size="100%">Jose Antonio Mondragon Herrera</style></author><author><style face="normal" font="default" size="100%">Maria Guadalupe Ramirez Sotelo</style></author><author><style face="normal" font="default" size="100%">Genaro Ivan Ceron Montes</style></author><author><style face="normal" font="default" size="100%">Yolanda de las Mercedes Gomez y Gomez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant-Like Effects of Dracocephalum moldavica L. in Mouse Models of Immobility Tests</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Dracochepalum moldavica L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail suspension test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">976-983</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this investigation was to evaluate the antidepressant activity of the ethanolic extracts of “toronjil azul”(&lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L.). &lt;strong&gt;Methodology:&lt;/strong&gt; The forced swimming test (FST) and tail suspension test (TST) were performed on CD-1 mice to evaluate the antidepressant activity of the ethanolic extracts. The ethanolic extracts were administered orally at an 80 and 100 mg/kg. The animals were dosed 1, 6 and 24 h before initiating the FST assay and 40 minutes before for the TST assay. Imipramine and fluoxetine were dosed at 15 mg/kg, while the flavonoid quercetin was given an a lower concentration of 10 mg/kg as a positive controls. &lt;strong&gt;Results:&lt;/strong&gt; The extracts of &lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L. and significantly decreased the immobility time in the FST and TST assays when compared with the negative control and reported similar values than those obtained with the positive controls. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results obtained indicate that extract of &lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L. have antidepressant effect similar to those obtained by.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">976</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marcos Ignacio Jiménez Zúñiga&lt;sup&gt;1&lt;/sup&gt;, Alejandro Jonathan Hurtado Mariles&lt;sup&gt;1&lt;/sup&gt;, José Luis Castrejón Flores&lt;sup&gt;2&lt;/sup&gt;, José Antonio Mondragón Herrera&lt;sup&gt;1,3&lt;/sup&gt;, María Guadalupe Ramírez Sotelo&lt;sup&gt;1&lt;/sup&gt;, Genaro Iván Cerón Montes&lt;sup&gt;4&lt;/sup&gt;, Yolanda de las Mercedes Gómez y Gómez&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratorio de Farmacología, Instituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Biotecnología Molecular y Cultivo Celular, Av. Acueducto, La Laguna Ticomán, C.P.: 07340, Gustavo A. Madero, Ciudad de México, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro Médico Nacional Siglo XXI, Hospital de Cardiología, Laboratorio de Patología Molecular, Avenida Cuauhtémoc 330, Doctores, C.P.: 06720, Cuauhtémoc, Ciudad de MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Tecnológica de Tecámac, Laboratorio de Bioprocesos, Carretera Federal México-Pachuca, Km. 37.5, Predio Sierra Hermosa, C.P. 55740. Tecámac, Estado de México, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Isni Rizqi Putri</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Elastase Activity of Rumput Teki (Cyperus rotundus L.) Rhizome Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cyperus rotundus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Elastase</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin ageing</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">754-758</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Excessive reactive oxygen species (ROS) often trigger the activation of elastase to degrade the elastin, an extracellular matrix (ECM) protein that provides resilience and elasticity of the skin. Therefore, the inhibition of elastase could reduce the wrinkles formation in the skin. Rumput teki (&lt;em&gt;Cyperus rotundus &lt;/em&gt;L.) is used empirically to increase the skin elasticity but the scientific justification was still limited. This study aimed to determine the activity of&lt;em&gt; Cyperus rotundus &lt;/em&gt;L (CyR) in inhibiting the elastase activity. &lt;strong&gt;Methods:&lt;/strong&gt; Extraction of CyR was performed by maceration method using 70% ethanol. The inhibition percentage and IC&lt;sub&gt;50&lt;/sub&gt; were determined by the colorimetric method using porcine pancreatic elastase (PPE) and N-Succ-(Ala)3-p- nitroanilide (SANA) as substrate. Phytochemical screening, determination of Total Phenolic content (TPC), and Total Flavonoid Content (TFC) were also performed to calculate the level of phenolic and flavonoid content in the sample.&lt;strong&gt; Results: &lt;/strong&gt;The extract of CyR rhizomes contained TPC and TFC of 62.72 mgGAE/g and 10.72 mgEQ/g extract respectively and showed an inhibitory activity on elastase with IC&lt;sub&gt;50&lt;/sub&gt; of 178.72 μg/mL, smaller than IC&lt;sub&gt;50&lt;/sub&gt; of quercetin as reference drug (200.00 μg/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; This finding suggested that extract of CyR rhizomes could be used as elastase inhibitor but the further research still needs to be developed.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">754</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Isni Rizqi Putri, Rosita Handayani, Berna Elya*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424 West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rohan S. Phatak</style></author><author><style face="normal" font="default" size="100%">Chitra C. Khanwelkar</style></author><author><style face="normal" font="default" size="100%">Somnath M. Matule</style></author><author><style face="normal" font="default" size="100%">Kailas D. Datkhile</style></author><author><style face="normal" font="default" size="100%">Anup S. Hendre</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antihyperlipidemic Activity of Murraya koenigii Leaves Methanolic and Aqueous Extracts on Serum Lipid Profile of High Fat-Fructose Fed Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Atherogenic index</style></keyword><keyword><style  face="normal" font="default" size="100%">High fat-fructose diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">lipid profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Murraya Koenigii</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">836-841</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dyslipidemia has been considered as one of coronary risk factors contributing to the cardiovascular diseases. The beneficial effects of &lt;em&gt;Murraya koenigii&lt;/em&gt; leaf on HFFD induced hyperlipidemia in rats has been very less reported in the recent review of literature.&lt;strong&gt; Aim and Objectives:&lt;/strong&gt; To study the hypolipidemic activity of &lt;em&gt;Murraya koenigii&lt;/em&gt; leaves on the serum lipid profile in HFFD rat model. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Thirty-six rats of either sex were randomly divided into six groups of six animals each. HFFD was fed p.o to all rats from Groups I, II, IV, V and VI except Group III throughout the period of 14 weeks. Group III rats received normal diet and water &lt;em&gt;ad libitum &lt;/em&gt;only. Group I, II, IV and V were treated respectively with AEMK (200 mg/kg/day, p. o), MEMK (200 mg/kg/day, p. o), MET (50 mg/kg/day, p. o) and ATO (10 mg/kg/day, p. o). On the last day of experimental study, blood was collected by retro-orbital puncture method. BSL and lipid profile were assessed. &lt;strong&gt;Results: &lt;/strong&gt;Elevated levels of TC, TG, LDL-C, VLDL-C and diminished level of HDL-C were observed in group VI. &lt;em&gt;Murraya koenigii&lt;/em&gt; leaves extract exhibited significant hypolipidemic effect on serum TC and LDL-C in rats owing to its hypocholesterolemic properties. AIP was highly significant in both of AEMK and MEMK extracts. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results of the present study have suggested that the antihyperlipidemic activity of &lt;em&gt;Murraya koenigii&lt;/em&gt; leaves leading to decrease in serum lipid parameters mainly TC, LDL-C along with atherogenic risk might be due to its presence of bioactive compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">836</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rohan S. Phatak&lt;sup&gt;1,*&lt;/sup&gt;, Chitra C. Khanwelkar&lt;sup&gt;1&lt;/sup&gt;, Somnath M. Matule&lt;sup&gt;1&lt;/sup&gt;, Kailas D. Datkhile&lt;sup&gt;2&lt;/sup&gt;, Anup S. Hendre&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Molecular Biology and Genetics, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Krishna Institute of Medical Sciences, Karad-415110, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Luján-Carpio Elmer</style></author><author><style face="normal" font="default" size="100%">Medina-Salazar Henry</style></author><author><style face="normal" font="default" size="100%">Mayor-Vega Alexander</style></author><author><style face="normal" font="default" size="100%">Medrano-Canchari Karola</style></author><author><style face="normal" font="default" size="100%">Mazuelos-Rivas María</style></author><author><style face="normal" font="default" size="100%">Lizarraga-Castañeda Zaida</style></author><author><style face="normal" font="default" size="100%">Pante-Medina Carlos</style></author><author><style face="normal" font="default" size="100%">Salazar-Granara Alberto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Inflammatory and Neurobehavioral Effects of the Leaves from Maytenus macrocarpa (Ruiz and Pavon) Briquet in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Maytenus</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Neurobehavioral manifestations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">75-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (Chuchuhuasi) has long been employed in Peru as a traditional alternative therapy for several diseases, including cancer, arthritis and diarrhea. Recent studies show that several species of Maytenus have effects on nociceptive and inflammatory signaling, as well as toxic effects on behavioral neuronal pathways.&lt;strong&gt; Aims:&lt;/strong&gt; The aim of this study is to evaluate the anti-inflammatory effects and neurobehavioral side manifestations of the leaf of&lt;em&gt; Maytenus macrocarpa&lt;/em&gt; (Ruiz and Pavón) Briquet. &lt;strong&gt;Methods and Materials:&lt;/strong&gt; Experimental study, double blind. 60 male albino mice strain Balb/c were divided in ten groups and each group, was orally feed with different doses of ethanolic extracts of &lt;em&gt;Maytenus macrocarpa&lt;/em&gt; (500, 750, 1000, 1250 and 1500 mg/kg), others group received distilled water, caffeine 32 mg/kg, diazepam 32 mg/kg, diclofenac 15 mg/kg and the last group without substance. Neurobehavioral effects were assessed by the Irwin test. The anti-inflammatory activity was measured by the Carrageenan paw oedema test. Statistical analysis was performed with ANOVA test and Fisher exact test. &lt;strong&gt;Results:&lt;/strong&gt; Anti-inflammatory effects of &lt;em&gt;M. macrocarpa&lt;/em&gt; were observed in a non-significant trend of dose dependent form. &lt;em&gt;M. macrocarpa&lt;/em&gt; displayed an anti-inflammatory effect at 1250 mg/kg and these effects were higher in comparison with diclofenac (74.14% vs 58.62%, one way ANOVA, &lt;em&gt;p&lt;/em&gt;&amp;lt;0.05). Neurobehavioral side effects secondary to &lt;em&gt;M. macrocarpa&lt;/em&gt; therapy were also identified, these included excitation, abnormal gait, abdominal cramps, piloerection, stereotypes and scratching (Fisher exact, p&amp;lt;0.05, CI 95%). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;M. macrocarpa&lt;/em&gt; leaves presented anti-inflammatory activity and concomitants neurobehavioral side effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">75</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Luján-Carpio Elmer&lt;sup&gt;1,2&lt;/sup&gt;, Medina-Salazar Henry&lt;sup&gt;1,2&lt;/sup&gt;, Mayor-Vega Alexander&lt;sup&gt;1,2&lt;/sup&gt;, Medrano-Canchari Karola&lt;sup&gt;1&lt;/sup&gt;, Mazuelos-Rivas María&lt;sup&gt;1&lt;/sup&gt;, Lizarraga-Castañeda Zaida&lt;sup&gt;1,2&lt;/sup&gt;, Pante-Medina Carlos&lt;sup&gt;1&lt;/sup&gt;, Salazar-Granara Alberto&lt;sup&gt;1,2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Universidad de San Martín de Porres. Facultad de Medicina Humana. Instituto de Investigación, Centro de Investigación de Medicina Tradicional y Farmacología. Lima, PERÚ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Sociedad Científica de Estudiantes de Medicina de la Universidad de San Martin de Porres. Lima, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Enrique Javier Aguilar-Felices</style></author><author><style face="normal" font="default" size="100%">Marta Romero-Viacava</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Pablo Común-Ventura</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Bertha Pari-Olarte</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Activity of the Germinated Seed of Four Varieties of Amaranthus Caudatus L. from Peru</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amaranthus caudatus L.</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Germinated seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">588-593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to determine the antioxidant activity of four varieties of germinated seeds of Centenario, Cristalino, Oscar Blanco and Taray of &lt;em&gt;Amaranthus caudatus&lt;/em&gt; L. compared to non-germinated seeds. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The determination of total phenols was carried out by using Folin-Ciocalteu, total flavonoids by the method of aluminum chloride and the antioxidant activity by the methods of DPPH, ABTS and FRAP. &lt;strong&gt;Results:&lt;/strong&gt; Cristalino variety had the highest germination (3.0 cm of height) and all varieties had a 50% germination rate. Cristalino and Taray varieties had the highest content of total phenolics (GAE 32.92 and 35.00 mg/g sample), Cristalino variety had higher content of flavonoids (580.95 mg QE/g) (P &amp;lt; 0.05); Cristalino and Taray varieties showed greater scavenging activity of DPPH radical (151.85 and 151.38 mg TE/g sample), ABTS (178.09 and 180.18 mg TE/g sample); and reducing capacity of the ferric ion (FRAP) (132.75 and 136.42 mg TE/g of sample). &lt;strong&gt;Conclusion:&lt;/strong&gt; Sprouts of Cristalino and Taray varieties had higher antioxidant activity than non-germinated seeds and they are directly related to higher content of total phenols and flavonoids.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">588</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Enrique Javier Aguilar- Felices&lt;sup&gt;1&lt;/sup&gt;, Marta Romero- Viacava&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;3&lt;/sup&gt;*, Pablo Común-Ventura&lt;sup&gt;1&lt;/sup&gt;, Ricardo Yuli-Posadas&lt;sup&gt;4&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;5&lt;/sup&gt;, Bertha Pari-Olarte&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Botany, Faculty of Biological Sciences, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy and Traditional Medicine, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iman Mansi</style></author><author><style face="normal" font="default" size="100%">Nasser A. Awadh Ali</style></author><author><style face="normal" font="default" size="100%">Nizar M. Mhaidat</style></author><author><style face="normal" font="default" size="100%">Khaled Hussain</style></author><author><style face="normal" font="default" size="100%">Ali G. Al-kaf</style></author><author><style face="normal" font="default" size="100%">Sirajudheen Anwar</style></author><author><style face="normal" font="default" size="100%">William N. Setzer</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Biological Activity of the Essential Oil Isolated from the Leaves of Achillea fragrantissima Growing Wild in Yemen</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achillea fragrantissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemisia ketone</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1077-1081</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Yemen is diverse in its geography and rich in its natural flora. &lt;em&gt;Achillea fragrantissima&lt;/em&gt; grown wild in Yemen is widely used in folkloric medicine. &lt;strong&gt;Objectives:&lt;/strong&gt; To investigate the chemical composition, cytotoxicity, xanthine oxidase inhibitory and tyrosinase inhibitory activities of the essential oil isolated form the leaves of &lt;em&gt;Achillea fragrantissima&lt;/em&gt; (Forssk.) Sch. Bip. growing wild in Yemen. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The oil was collected after hydrodistillation for 3 h, the oil composition was analyzed by GC-MS and assayed for biological activities. Results: Artemisia ketone (49.53%), camphor (14.73%), α-bisabolol (11.20%), α-bisabolol oxide B (2.62%) were the main components of the oil. The MTT assay of the oil on two human colorectal cancer cell lines (SW480 and HCT-116) showed IC&lt;sub&gt;50&lt;/sub&gt; values of 110.1 and 134.6 μg ml⁻¹, respectively. Xanthine oxidase inhibitory and tyrosinase inhibitory activity assays were performed but exhibited only marginal activities. &lt;strong&gt;Conclusion: &lt;/strong&gt;the components of the essential oil could be excellent anticancer drugs for treatment of colon cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1077</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Iman Mansi&lt;sup&gt;1,&lt;/sup&gt;*, Nasser A. Awadh Ali&lt;sup&gt;2,3&lt;/sup&gt;, Nizar M. Mhaidat&lt;sup&gt;4&lt;/sup&gt;, Khaled Hussain&lt;sup&gt;5&lt;/sup&gt;, Ali G. Al-kaf&lt;sup&gt;3&lt;/sup&gt;, Sirajudheen Anwar&lt;sup&gt;6&lt;/sup&gt;, William N. Setzer&lt;sup&gt;7,8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical pharmacy and Pharmacy Practice, Faculty of Pharmaceutical sciences, The Hashemite University, P.O. Box 330127, Zarqa 13133, JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, Faculty of Clinical Pharmacy, Albaha University, Al Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Pharmacognosy &amp;amp; Medicinal Chemistry Department, Faculty of Pharmacy, Sana’a University, Sana’a, YEMEN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of clinical pharmacy and Pharmacy practice, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid-JORDAN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Chemistry Department, Faculty of Sciences, Sana’a University, YEMEN.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Pharmacology &amp;amp; Toxicology Department, Faculty of Clinical Pharmacy,Hail University, Hail, KSA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ali Mohamed El Shamy</style></author><author><style face="normal" font="default" size="100%">Seham Salah El Din El Hawary</style></author><author><style face="normal" font="default" size="100%">Heba Ahmed Fahmy</style></author><author><style face="normal" font="default" size="100%">Shahira Mohammed Ezzat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative DNA Fingerprinting and Botanical Study of Certain Haworthia and Gasteria Species Growing in Egypt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gasteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Haworthia</style></keyword><keyword><style  face="normal" font="default" size="100%">Macromorphology</style></keyword><keyword><style  face="normal" font="default" size="100%">Micromorphology</style></keyword><keyword><style  face="normal" font="default" size="100%">RAPD-PCR</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">388-394</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Haworthia&lt;/em&gt; Duval and &lt;em&gt;Gasteria&lt;/em&gt; Duval are succulent plants, native to South Africa. They have been used worldwide in folk medicine. They are members of the Alooideae subfamily, which has been always viewed as a taxonomically confusing sub-family. The present study aims to differentiate between &lt;em&gt;Haworthia limifolia&lt;/em&gt; Marloth, &lt;em&gt;Gasteria carinata&lt;/em&gt; (Mill.) Duval and &lt;em&gt;Gasteria minima&lt;/em&gt; Poelln. growing in Egypt. &lt;strong&gt;Methods:&lt;/strong&gt; A comparative botanical and genetic investigation is presented. Macromorphological and micromorphological botanical features of the leaves and stems of the species under investigation using the entire specimens, transverse sections and isolated elements. Moreover, their DNA was extracted from the leaf samples and RAPD-PCR analysis was made using 10 primers. &lt;strong&gt;Results:&lt;/strong&gt; The comparative botanical criteria of the examined leaves and stems were identified. Furthermore, the total number of amplified products produced by the ten primers was 98 fragments. Primers OPB-07, OPB-01 and OPB-02, recording high percentage of polymorphism (78.6, 70.6 and 57.1%, respectively), can be used to differentiate between the examined species. While primers OPB-01, OPB-04, OPB-07 and OPB-08, generating fragments with wide molecular size (17, 14, 14 and 11fragments, respectively), can be used for the identification of &lt;em&gt;Haworthia limifolia&lt;/em&gt;, &lt;em&gt;Gasteria carinata&lt;/em&gt; and &lt;em&gt;Gasteria minima&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The macromorphological, micromorphological and genetic identifying parameters presented in the current study revealed good crieteria to authenticate and differentiate between &lt;em&gt;Haworthia limifolia&lt;/em&gt; Marloth, &lt;em&gt;Gasteria carinat&lt;/em&gt;a (Mill.) Duval and &lt;em&gt;Gasteria minima&lt;/em&gt; Poelln.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Ali Mohamed El Shamy&lt;sup&gt;1&lt;/sup&gt;, Seham Salah El Din El Hawary&lt;sup&gt;1&lt;/sup&gt;, Heba Ahmed Fahmy&lt;sup&gt;2,&lt;/sup&gt;*, Shahira Mohammed Ezzat&lt;sup&gt;1,3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, 11562, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th October, 12566, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hamdoon Abdelhamid Mohammed</style></author><author><style face="normal" font="default" size="100%">Mohsen Saleh Al-Omer</style></author><author><style face="normal" font="default" size="100%">Adel Mohammed Ahmed</style></author><author><style face="normal" font="default" size="100%">Nadia Elbialy Hashish</style></author><author><style face="normal" font="default" size="100%">Hasan Meshal Alsaedi</style></author><author><style face="normal" font="default" size="100%">Suliman Abdulaziz Alghazy</style></author><author><style face="normal" font="default" size="100%">Ahmed Abdelfattah Hafez Abdellatif</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Study for the Volatile Oil Constituents and Antimicrobial Activity of Rhanterium epapposum Oliv. Growing in Qassim, Saudi Arabia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Comparative study</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Hot extraction. Cold extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhanterium epapposum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">195-199</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Rhanterium epapposum&lt;/em&gt; is an herbaceous plant widely distributed in the Gulf region and used by Bedouins as antiseptic for wounds, skin infections and in gastrointestinal disturbances. &lt;strong&gt;Aim:&lt;/strong&gt; The study aimed to compare the results obtained from volatile oil analysis of &lt;em&gt;R. epapposum &lt;/em&gt;growing in Buraydah, Qassim with reported data of the same plant growing in Riyadh “Al-Majmaah” and Northern border region of Saudi Arabia. Both cold and hot extracts of the &lt;em&gt;R. epapposum &lt;/em&gt;were used to find the best extraction method to be adopted as an antimicrobial agent. Methods: Volatile oils were distillated using Clevenger apparatus and analyzed by GC-MS. The plant powder was extracted by cold maceration and hot contentious extraction methods. Furthermore, antimicrobial activity was conducted using the agar diffusion method.&lt;strong&gt; Results:&lt;/strong&gt; The hydro-distillation of &lt;em&gt;R. epapposum&lt;/em&gt; growing in Qassim region yielded 0.5 % w/w of the total volatile oils. Moreover, forty-three compounds of 97.68% of the volatile oil components were identified while modephene, caryophyllene, linalyl acetate and epizonarene were the major components of volatile oils. Nevertheless, the volatile oils diversity and concentrations were found to be different in &lt;em&gt;R. epapposum &lt;/em&gt;growing in Buraydah, as compared with the plant growing in Riyadh and the northern border region of Saudi Arabia which almost due to the differences in the environmental condition. Among all extracts, ethyl acetate hot extract showed the best inhibition to bacterial strains while fugal strain &lt;em&gt;Candida albicans&lt;/em&gt; growth was better inhibited by hot &lt;em&gt;n&lt;/em&gt;-hexane extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Volatile oils were active against all microbial strains. Hot extracts were more active against bacterial strains while the opposite effects were found against &lt;em&gt;Candida albicans &lt;/em&gt;which was generally inhibited by the cold extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hamdoon Abdelhamid Mohammed&lt;sup&gt;1,2,*&lt;/sup&gt;, Mohsen Saleh Al-Omer&lt;sup&gt;1&lt;/sup&gt;, Adel Mohammed Ahmed&lt;sup&gt;1&lt;/sup&gt;, Nadia Elbialy Hashish&lt;sup&gt;1,6&lt;/sup&gt;, Hasan Meshal Alsaedi&lt;sup&gt;3&lt;/sup&gt;, Suliman Abdulaziz Alghazy&lt;sup&gt;3&lt;/sup&gt;, Ahmed Abdelfattah Hafez Abdellatif&lt;sup&gt;4,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Medicnal Chemistry and Pharmacognosy department, Faculty of Pharmacy, Qassim University, Buraydah, 51452, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy department, Faculty of Pharmacy, Al-Azhar University, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Pharm. D. student, Faculty of Pharmacy, Qassim University, Buraydah, 51452, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutics and Industrial pharmacy department, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmaceutics department, Faculty of Pharmacy, Qassim University, Buraydah, 51452, KINGDOM OF SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pharmacognosy , College of Pharmacy, Mansoura University, Egypt).&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Nurrashida Binti Mok Hallim</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Anwar Ibrahim</style></author><author><style face="normal" font="default" size="100%">Salinah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between the Effect of Precipitate and Supernatant Aloe vera Gel on Experimental Cutaneous Wound Healing Using Optical Coherence Tomography</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aloe vera</style></keyword><keyword><style  face="normal" font="default" size="100%">OCT</style></keyword><keyword><style  face="normal" font="default" size="100%">Precipitate</style></keyword><keyword><style  face="normal" font="default" size="100%">Supernatant</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">405-412</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Wound healing is a fundamental response to injured tissue that results in the restoration of tissue integrity. One of the famous herbs that promote wound healing is &lt;em&gt;Aloe vera&lt;/em&gt;. Despite well known for its therapeutic effect, several studies reported inconclusive evidence regarding this. Besides, lack of evidence to postulate the superior effect of two components of Aloe vera which are the precipitate and supernatant. &lt;strong&gt;Objective:&lt;/strong&gt; Study compares the effects of precipitate and supernatant in promoting tissue repair. Evaluation takes place by using optical Coherence Tomography (OCT) and is comparable with histopathology study. &lt;strong&gt;Methods:&lt;/strong&gt; Twelve male mice were randomly divided into four groups (precipitate, supernatant, control 50% ethanol, and normal). 200 mg of Aloe vera was extracted. A standardized 2 cm longitudinal incision wound was created. All mice were given topical &lt;em&gt;Aloe vera&lt;/em&gt;, 0.5 g each, once daily and assessment of wound surface was performed using OCT. The animals were sacrificed on day 10 to evaluate histopathologically. &lt;strong&gt;Results:&lt;/strong&gt; R parameter from the OCT was utilized to analyze the data. There is no significant difference in the treatment effect between &lt;em&gt;Aloe vera&lt;/em&gt; treated group and control on day 10 post-injury. Treated animals with precipitate did not differ significantly from supernatant treated group. Nevertheless, from histopathology analysis, precipitate showed better wound reepithelialisation, collagen formation and angionesis despite having numerous inflammatory cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; OCT using R parameter is not the best choice to detect wound healing. Nevertheless, from histopathological perspective, Aloe vera accelerates wound healing and precipitate Aloe vera gel does have a superior effect from supernatant in promoting wound healing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Nurrashida Binti Mok Hallim&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Anwar Ibrahim&lt;sup&gt;3&lt;/sup&gt;, Salinah&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Anatomical Pathology, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Medicinal Chemistry, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Medicinal Physic, Faculty of Medicine, Universitas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hesti Riasari</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Rika Hartati</style></author><author><style face="normal" font="default" size="100%">Kusnandar Anggadiredja</style></author><author><style face="normal" font="default" size="100%">Sukrasno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Extraction Methods, Antioxidant Activities, Total Phenol in Seeds and Seed Shells of Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) From Lampung and South Sumatra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Archidendron bubalinum (Jack) Nielsen</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Seed shell</style></keyword><keyword><style  face="normal" font="default" size="100%">Seeds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1278-1284</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Kabau is one of the famous plants in Lampung and South Sumatra. Kabau is usually used as an ingredient to increase the aroma of cooking. Kabau is a plant belongs to the same genus with &lt;em&gt;Archidendron pauciflorium&lt;/em&gt; (Benth.) IC. Nielsen and in the same family with &lt;em&gt;Leucaena leucocephala &lt;/em&gt;L. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this research was to compare the total phenolic content and the antioxidant activity between seed and fruit carp (shell) of kabau grown in Lampung and South Sumatra. &lt;strong&gt;Method: &lt;/strong&gt;Kabau seeds and the shells were obtained from Lampung and South Sumatra. Extractions were conducted by maceration and a continuous extraction using Soxhlet apparatus with ethanol as the solvent. Phenolic content and the antioxidant activity of the extract were then measured. &lt;strong&gt;Results:&lt;/strong&gt; The antioxidant activity and high phenol levels were found in kabau shell extract obtained by maceration method with IC-50 value of seed shell from Lampung 17.61 μg/mL and 44, 7 μg / mL for those from South Sumatra. Phenol content of seed shell from Lampung 11.74 g GAE / 100 g and South Sumatra 5.88 g GAE / 100 g&lt;strong&gt;. Conclusion: &lt;/strong&gt;Based on the research that has been done, it can be concluded that high antioxidant activity and high levels of total phenol were found in shell extract obtained by maceration of shell from Lampung and South Sumatra.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1278</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hesti Riasari&lt;sup&gt;1,2&lt;/sup&gt;,*, Sani Nurlaela Fitriansyah&lt;sup&gt;2&lt;/sup&gt;, Rika Hartati&lt;sup&gt;1&lt;/sup&gt;, Kusnandar Anggadiredja&lt;sup&gt;1&lt;/sup&gt;, Sukrasno&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, Bandung 40132, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian School of Pharmacy. Jl. Soekarno Hatta 354, Bandung 40266 West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Towseef Hassan</style></author><author><style face="normal" font="default" size="100%">Elanchezhiyan C</style></author><author><style face="normal" font="default" size="100%">Insha Naseer</style></author><author><style face="normal" font="default" size="100%">S Marimuthu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Perillyl Alcohol (POH) A Monoterpene on Lipid Peroxidation and Antioxidant Status in High Fat Diet-Low Dose STZ Induced Type 2 Diabetes in Experimental Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">High Fat Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Perillyl alcohol</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptozotocin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1434-1441</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The plan of this study was to assess the protective activity of Perillyl alcohol (POH) on the levels of lipid peroxidation (LPO) by-products and antioxidant defense systems in the plasma and other tissues of normal and High Fat Diet-Low Dose Streptozotocin (STZ) induced type 2 diabetes in wistar rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The experimental diabetes was induced in animals by High Fat Diet-Low Dose STZ (35 mg/kg i.p.) injection, and treatment with Perillyl alcohol at the dose of (50mg/kg b.w and 100mg/kg b.w) was continued for 30 days. At the end of treatment period, oxidative stress parameters like lipid peroxidation by-products; enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-enzymic antioxidants including reduced glutathione, Vitamin C and Vitamin E were measured in the plasma and tissues of experimental rats. &lt;strong&gt;Results:&lt;/strong&gt; In untreated diabetic rats an increase was seen in the levels of lipid peroxidation by-products and significant decrease was seen in antioxidant enzymes. Oral administration of Perillyl alcohol a monocyclic monoterpene to diabetic rats for 30 days caused a significant reduction in the levels of lipid peroxidation by-products and an increase in the activities of antioxidant enzymes, when the same were compared with the untreated diabetic group. &lt;strong&gt;Conclusion:&lt;/strong&gt; The result of this study indicates that Perillyl alcohol has anti lipid peroxidation and antioxidant status potential in experimental diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1434</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Towseef Hassan, Elanchezhiyan C*, Insha Naseer, S. Marimuthu&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Zoology, Annamalai University, Annamalainagar, Chidambaram-608002, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eka Sunarwidhi Prasedya</style></author><author><style face="normal" font="default" size="100%">Ni Wayan Riyani Martyasari</style></author><author><style face="normal" font="default" size="100%">Candra Dwipayana Hamdin</style></author><author><style face="normal" font="default" size="100%">Masao Miyake</style></author><author><style face="normal" font="default" size="100%">Daisuke Kobayashi</style></author><author><style face="normal" font="default" size="100%">Sri Widyastuti</style></author><author><style face="normal" font="default" size="100%">Akihiro Hazama</style></author><author><style face="normal" font="default" size="100%">Haji Sunarpi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effectiveness of Methanol Solvent Extraction for Red Macroalgae Acanthophora spicifera Antitumoric Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acanthophora</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroalgae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">450-454</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Red macroalgae &lt;em&gt;Acanthophora spicifera&lt;/em&gt; is commonly found in most parts of Indonesia coastal areas. However, information regarding their potential pharmaceutical uses remains largely unexplored. This study evaluates the antiproliferative activity of &lt;em&gt;Acanthophora spicifera&lt;/em&gt; collected from Indonesian extracted with different solvents of ethanol and methanol. &lt;strong&gt;Methods:&lt;/strong&gt; Cytotoxicity and antiproliferative activity of &lt;em&gt;A. spicifera&lt;/em&gt; crude ethanol extract (AS-EtOH) and &lt;em&gt;A. spicifera&lt;/em&gt; crude methanol extract (AM-MetOH) were evaluated with Lactate dehidrogenase (LDH) and Trypan blue exclusion assay in Human cervical cancer (HeLa) cells for 72h. Concentration of extracts treated in HeLa cells were 6.25 to 200 &lt;em&gt;μ&lt;/em&gt;g/mL. Viability staining with fluorescence stain Hoechst33342/PI was conducted to investigate apoptotic activity. Potential apoptotic activity of treatments was confirmed by DNA fragmentation assay. &lt;strong&gt;Results:&lt;/strong&gt; AS-MetOH demonstrated high cytotoxicity in HeLa cells with IC&lt;sub&gt;50&lt;/sub&gt; of 127.3 ± 33.13 &lt;em&gt;μ&lt;/em&gt;g/mL. However, AS-EtOH IC&lt;sub&gt;50&lt;/sub&gt; values could not be determined in this study. Antiproliferative activity was highly significant in AS-MetOH treated cells as cell density was suppressed to 20 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL compared to AS-EtOH (73 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL) and untreated cells (83 x 10&lt;sup&gt;4&lt;/sup&gt; cells/mL). Finally, apoptotic activity could be determined in AS-MetOH treated cells with increase PI fluorescence emitting cells and DNA fragmentation. On the other hand, apoptotic activity was not observable in AS-EtOH treated cells based on fluorescence viability staining and DNA fragmentation assay. &lt;strong&gt;Conclusion:&lt;/strong&gt; Current results show methanol solvent as an effective solvent to promote potential pharmaceutical properties of macroalgae &lt;em&gt;A. spicifera. &lt;/em&gt;Further advanced studies in a compound level from&lt;em&gt; A. spicifera&lt;/em&gt; methanol fraction would be reasonable for development of macroalgae based anticancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eka Sunarwidhi Prasedya&lt;sup&gt;1&lt;/sup&gt;, Ni Wayan Riyani Martyasari&lt;sup&gt;2&lt;/sup&gt;, Candra Dwipayana Hamdin&lt;sup&gt;2&lt;/sup&gt;, Masao Miyake&lt;sup&gt;4&lt;/sup&gt;, Daisuke Kobayashi&lt;sup&gt;4&lt;/sup&gt;, Sri Widyastuti&lt;sup&gt;3&lt;/sup&gt;, Akihiro Hazama&lt;sup&gt;4&lt;/sup&gt;, Haji Sunarpi&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bioscience and Biotechnology Research Centre, Faculty of Mathematics and Natural Sciences, University of Mataram, Nusa Tenggara Bar- 83126, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Medical Faculty, University of Mataram, Nusa Tenggara Bar-83126 INDONSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Food Science and Agroindustrial Technology, University of Mataram, Nusa Tenggara Bar-83126 INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Cellular and Integrative Physiology, Fukushima Medical University, Fukushima, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Najib</style></author><author><style face="normal" font="default" size="100%">Aktsar Roskiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Virsa Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">ELISA Test on Cordia myxa L. Leaf Extract for alpha-Glucosidase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acarbose</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordia myxa L.</style></keyword><keyword><style  face="normal" font="default" size="100%">ELISA</style></keyword><keyword><style  face="normal" font="default" size="100%">IC50</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">358-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aimed:&lt;/strong&gt; Determine the potential of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf on inhibited α-glucosidase. Material: ELISA Kit, Ethanol 96%, Colomn Chromatography, n-hexane, ethyl acetate, Glocobay®.&amp;nbsp; &lt;strong&gt;Method:&lt;/strong&gt; Sample from &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf extracted by ethanol 96% then evaporated to get the sticky extract. The sticky extract of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf fractionated by column chromatography with n-hexane, n-hexane: ethyl acetate (90:10; 80:20; 75:25; 70:30; 65:35; 60:40; 55:45; 50:50) &lt;strong&gt;Assay:&lt;/strong&gt; The fractions assayed by ELISA (Enzyme-Linked Immunosorbent Assay) with acarbose (Glucobay ®) as the comparator.&lt;strong&gt; Result:&lt;/strong&gt; The results showed that the n-hexane fraction is the highest potency on inhibited α-glucosidase with the noncompetitive mechanism. The IC&lt;sub&gt;50&lt;/sub&gt; of n-hexane fraction is 0.53 ppm been while the acarbose is 6.85 ppm. &lt;strong&gt;Conclusion:&lt;/strong&gt; The n-hexane fraction of &lt;em&gt;Cordia myxa&lt;/em&gt; L. leaf has the highest potency to use for possible decrease blood glucose level.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ahmad Najib&lt;sup&gt;1,*&lt;/sup&gt;, Aktsar Roskiana Ahmad&lt;sup&gt;1&lt;/sup&gt;, Virsa Handayani&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Phytochemistry Division-Pharmacognosy- Phytochemistry Laboratory, Faculty of Pharmacy Universitas Muslim Indonesia, Makassar- INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Division-Pharmacognosy- Phytotochemistry Laboratory, Faculty of Pharmacy Universitas Muslim Indonesia, Makassar- INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusnandar Anggadiredja</style></author><author><style face="normal" font="default" size="100%">I Ketut Adnyana</style></author><author><style face="normal" font="default" size="100%">Dewi Safitri</style></author><author><style face="normal" font="default" size="100%">Siti Farah Rahmawati</style></author><author><style face="normal" font="default" size="100%">Tomi Hendrayana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanol Extract of Gardenia augusta (L.) Merr. Flowers Produces Sleep Improvement in Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flowers</style></keyword><keyword><style  face="normal" font="default" size="100%">Gardenia augusta (L.) Merr.</style></keyword><keyword><style  face="normal" font="default" size="100%">Improvement</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword><keyword><style  face="normal" font="default" size="100%">Sleep</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1449-1454</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sleep disorder may have detrimental consequences on health and one of the treatments is the use of hypnotics. Unfortunately, hypnotics treatment may also be accompanied by side effects and lead to dependence. The present study aimed to investigate the sleep improving effects of ethanol extract of &lt;em&gt;Gardenia augusta&lt;/em&gt; (L.) Merr. flowers in rat model. &lt;strong&gt;Methods: &lt;/strong&gt;Rats were assigned into group receiving the extract (at 0.9 or 1.8 g/kg), the reference drug crocetin (at 0.9 mg/kg) or vehicle, once a day orally for 15 days. &lt;strong&gt;Results: &lt;/strong&gt;Tested on day 1 and 14 of treatment, the rats receiving 1.8 g/kg of the extract showed improvements in sleep latency, sleep duration, sleep efficiency, wake episodes, and sleep cycle, which were significantly different from crocetin. Furthermore, tested on day 2 and 15 of treatment, the rats treated with 1.8 g/kg extract demonstrated superior sedative rating scale compared to crocetin. &lt;strong&gt;Conclusions: &lt;/strong&gt;Results of the present study indicates the potential of Gardenia augusta (L.) Merr. flower extract to be used as an adjunct treatment for sleep disorder.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1449</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusnandar Anggadiredja*, I Ketut Adnyana, Dewi Safitri, Siti Farah Rahmawati, Tomi Hendrayana&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology and Clinical Pharmacy, School of Pharmacy Institut Teknologi Bandung, Jl. Ganesa 10 Bandung 40132, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ghanashyam Mahato</style></author><author><style face="normal" font="default" size="100%">Bangamoti Hansda</style></author><author><style face="normal" font="default" size="100%">Nilanjana Banerjee</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanicals used for the Treatment of Skin Diseases with Special Emphasis on Carbuncle Disease from Purulia District of West Bengal in India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbuncle</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Fidelity level</style></keyword><keyword><style  face="normal" font="default" size="100%">Informant consensus factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Purulia</style></keyword><keyword><style  face="normal" font="default" size="100%">Use value</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">745-753</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;From time immemorial ethnic people of Purulia district of West Bengal are well acquainted with different plant resources for the treatment of various skin diseases including 'carbuncle' and others skin diseases. Carbuncle, caused by the methicillin resistant Staphylococcus aureus is of major concern in this part of India, mostly dominated by tribes like Majhi, Munda, Santal, Birhor, Ho and Rajwar etc. Hot climate, overcrowded households, improper sanitation, very poor economic background and frequent burn accidents are of major issues for spreading of these bacterial infections. &lt;strong&gt;Objective:&lt;/strong&gt; Present authors are trying to summarize these ethno-medicinal knowledge of the local, conservative traditional healers by using structured questionnaires given to them and are trying to analyze these information from scientific perspective. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Plant samples were collected from March 2014 to May 2016, mostly during their flowering stage and a total of 62 people, both male (84%) and female (16%) were interviewed. Informant consensus factor, fidelity level and use value were calculated. &lt;strong&gt;Results:&lt;/strong&gt; Fifty-nine herbal plants belongs to 35 families were recorded for the cure of various skin diseases, among which 10 plants are used individually during medication whereas 9 polyherbal formulations were used in various combinations during treatment. Five species of the families Moraceae and Asteraceae was found to be the most common medicinal plants, among which 44.89% are herbaceous in habit. Leaves (55.55%) are the most common plant part for their use. &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, the present paper has been written to document this rapidly vanishing huge knowledge of folklore which should be digitally conserved for futuristic approach on medicinal plants in India.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">745</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ghanashyam Mahato&lt;sup&gt;1&lt;/sup&gt;, Bangamoti Hansda&lt;sup&gt;2&lt;/sup&gt;, Nilanjana Banerjee&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Assistant Professor, Department of Botany, A.M. College, Jhalda, Purulia, West Bengal-723202, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Scholar, Department of Botany and Forestry, Vidyasagar University, Midnapore, West Bengal-721102, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Botany, Vidyasagar University, Paschim Medinipur, West Bengal-721102, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Md. Mahmudul Hasan</style></author><author><style face="normal" font="default" size="100%">Md. Rezuan Al Mahmud</style></author><author><style face="normal" font="default" size="100%">Md. Gaziul Islam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of Bio-active Compounds in Ethanol Extract of Putranjiva roxburghii Wall. Fruit Peel</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit peel</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmaceutical ingredients</style></keyword><keyword><style  face="normal" font="default" size="100%">Putranjiva roxburghii</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">146-149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Putranjiva roxburghii&lt;/em&gt; Wall. has long been used in folkloric medicine for treating arthralgia, fever, hemorrhoids, muscle pain and rheumatism. But no reports were found regarding phytochemical constituents in &lt;em&gt;P. roxburghii&lt;/em&gt; fruit peel. Therefore, this study was designed to analyze extract of &lt;em&gt;P. roxburghii&lt;/em&gt; fruit peel (PRFP). &lt;strong&gt;Methods:&lt;/strong&gt; Gas chromatography-mass spectrometry (GC-MS) analysis of the ethanol extract of PRFP was carried out by using a GC-MS equipment. &lt;strong&gt;Results:&lt;/strong&gt; The GC-MS analysis has revealed the existence of different phytochemical compounds in the ethanolic extract of PRFP. The major compounds in PRFP extract are Cyclohexanol, 5-methyl-2-(1-methylethenyl)- (4.56%), 6-Octen-1-ol, 3,7-dimethyl- (41.07%), Geraniol (2.45%), (1R,2S,5R)-2-(2-Hydroxy-2-propanyl)-5-methylcyclohexanol (14.09%), 2,6-Octadiene, 2,6-dimethyl- (7.04%), p-Menthane-3,8-diol, cis-1,3,trans-1,4- (3.39%), 2,6-Octadien- 1-ol, 3,7-dimethyl-, acetate (6.69%) and 13-Docosenamide, (Z)- (2.83%). A total of 25 compounds identified representing 99.98% of total ethanolic extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall finding suggests that PRFP contain various phytocomponents and is recommended as an important source of pharmaceutical ingredients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">146</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Md. Mahmudul Hasan&lt;sup&gt;*&lt;/sup&gt;, Md. Rezuan Al Mahmud, Md. Gaziul Islam&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Molecular Biology and Protein Science Laboratory, Department of Genetic Engineering and Biotechnology, Faculty of Life and Earth Sciences, University of Rajshahi, Rajshahi-6205, BANGLADESH.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Boualem HARFI</style></author><author><style face="normal" font="default" size="100%">Lakhdar KHELIFI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hairy Root Technology: Effect of Etiolation on Datura sp. Transgenic Root Induction and Hyoscyamine Production</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Datura sp.</style></keyword><keyword><style  face="normal" font="default" size="100%">Etiolation</style></keyword><keyword><style  face="normal" font="default" size="100%">Gas chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">Hairy roots</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyoscyamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">991-995</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Hyoscyamine, because of its medicinal properties, is an important tropane alkaloid. In order to implement a biotechnological process for its production, hairy roots of&lt;em&gt; Datura &lt;/em&gt;species resulting from genetic transformation by &lt;em&gt;Agrobacterium rhizogenes&lt;/em&gt; A4 strain have been the subject of this work. In the &lt;em&gt;in vitro &lt;/em&gt;alkaloids production programs, optimization of the transformation is a crucial step for obtaining a large number of root lines allowing the selection of efficient lines. &lt;strong&gt;Methods:&lt;/strong&gt; The conditions for hairy roots induction were explored by studying the effect of &lt;em&gt;Datura&lt;/em&gt; sp. &lt;em&gt;in vitro&lt;/em&gt; seedling etiolation on the genetic transformation. The first step was the establishment of &lt;em&gt;Datura&lt;/em&gt; &lt;em&gt;in vitro&lt;/em&gt; plantlet cultures followed by the hairy roots induction with A4 strain of &lt;em&gt;A. rhizogenes&lt;/em&gt;. The confirmation of the genetic transformation was performed by polymerase chain reaction (PCR) analysis of rolB gene in the roots. After hyoscyamine extraction, it was analyzed (quantitatively and qualitatively) by gas chromatography. Results: 343 root lines were obtained in total, 96 root lines from non-etiolated &lt;em&gt;Datura in vitro&lt;/em&gt; seedlings and 247 root lines from etiolated &lt;em&gt;in vitro&lt;/em&gt; plantlets. After the selection of six transgenic root lines, tow root lines from each species (&lt;em&gt;D. tramonium, D. tatula &lt;/em&gt;and&lt;em&gt; D. innoxia&lt;/em&gt;), one from non-etiolated &lt;em&gt;in vitro &lt;/em&gt;plantlet and one from etiolated &lt;em&gt;in vitro&lt;/em&gt; plantlet, the most hyoscyamine content was 8.43 mg/g D.W. obtained with &lt;em&gt;D. tatula&lt;/em&gt; etiolated &lt;em&gt;in vitro&lt;/em&gt; seedling. &lt;strong&gt;Conclusion: &lt;/strong&gt;The etiolated&lt;em&gt; in vitro&lt;/em&gt; plantlets seem more favorable to hairy roots induction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">991</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Boualem HARFI&lt;sup&gt;1,2,&lt;/sup&gt;*, Lakhdar KHELIFI&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Biotechnology Research Center (C.R.Bt), Constantine, ALGERIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;National Higher School of Agronomy (ENSA – El-Harrach), Algiers, ALGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwitiyanti</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Solvent on the Characteristics of Standardized Binahong Leaf (Anredera cordifolia (Ten.) Steenis)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anredera cordifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">LCMS</style></keyword><keyword><style  face="normal" font="default" size="100%">Simplicia</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1463-1470</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Binahong is a plant that has the potential to be used as a traditional herbal medicine in Indonesia, and has several kinds of classes of compounds, one of them is a flavonoids glycosides (vitexin). Previous research reported that binahong leaves have pharmacological activities as antihyperglycemic, antihyperlipidemic, antibacterial, and others. A traditional plant that has proven efficacious needs to be standardized to ensure the quality and its safety. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to characteristics of binahong leaves simplicia obtained from Bogor, West Java. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The crude extract was obtained by the maceration method using 40%, 70%, and 96% ethanol solvent. The selected extract then standardized, which includes macroscopic and microscopic observations and sets the standard parameter values binahong leaf extract. Parameters LCMS to identify active compounds semiquantitatively. &lt;strong&gt;Results: &lt;/strong&gt;The yield of binahong ethanol extract from 40%, 70%, 96% showed a value of 10.9%, 11.4%, and 12.32%, respectively. From these results, 96% ethanol extract has proceeded for standardization. Macroscopic observation results showed that binahong leaves simplicia has a fine and notched form with 5-10 cm long and 3-7 cm diameter. The microscopic binahong leaves contain palisade tissue, parenchymal tissue, chlorophyll grains, rosette Caoxalate crystals, and spiral type. Phytochemical screening of binahong leaves showed the presence of alkaloids, flavonoids, saponins, tannins, steroids, and phenolic compounds.The standardization of binahong leaves ethanol extract down showed a levels of ethanol-soluble extract&amp;gt; 14.8%, water-soluble extract content &amp;gt; 13.5%, drying &amp;lt; 10%, water content &amp;lt; 8.9%, total ash content &amp;lt; 7.2%. LCMS profiles showed that ethanolic extract 40%, 70%, and 96% all contained vitexin at retention time 5.02 minutes, and m/z values 433.1111. &lt;strong&gt;Conclusion: &lt;/strong&gt;96% ethanolic extract of binahong leaves contains vitexin with pharmacognostic parameters carried out following the standards listed in the Indonesian herb pharmacopeia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1463</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwitiyanti&lt;sup&gt;1&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;3&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;4,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduated Program of Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Bioanalysis and Bioequivalence, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Stefandi J Wijaya</style></author><author><style face="normal" font="default" size="100%">Arry Yanuar</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Rezi Riadhi Syahdi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico Analysis of Flavonoid Glycosides and its Aglycones as Reverse Transcriptase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Reverse transcriptase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1252-1255</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; HIV continues to be a major global public health issue, having claimed more than 35 million lives so far. In 2016, 1 million people died from HIV-related causes globally. HIV-1 reverse transcriptase is one of HIV’s vital enzymes for virus reproduction. If the enzyme is inhibited, the virus multiplication could be significantly decreased. There are currently many treatments for HIV, but more effective treatment is always needed because of the possibility of drug resistance and side effects for long-term use. Based on the previous study, there are some natural compounds with high affinity to the HIV-1 reverse transcriptase enzyme. Some of these compounds are flavonoid glycosides. &lt;strong&gt;Aims and Method:&lt;/strong&gt; This study was aimed to learn more about &lt;em&gt;in silico&lt;/em&gt; HIV-1 reverse transcriptase inhibitory activities of flavonoid glycosides using docking method. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that the most recommended flavonoid glycosides are those with the lowest binding energy, which were kaempferol-3-O-rhamnoside, myricetin-3-O-rhamnoside and quercetin-3-O-rhamnoside. This was due to the interactions of all three flavonoid rings and sugar moiety with key amino acid residues, which were Leu100, Lys101, Glu138, Tyr181, His235 and Tyr318. &lt;strong&gt;Conclusion: &lt;/strong&gt;Flavonoid glycosides with rhamnose as glycone showed lower binding energy on HIV-1 reverse transcriptase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Stefandi J Wijaya, Arry Yanuar, Rosita Handayani, Rezi Riadhi Syahdi* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mfengwana Polo-Ma-Abiele H</style></author><author><style face="normal" font="default" size="100%">Mashele Samson S</style></author><author><style face="normal" font="default" size="100%">Manduna Idah T</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antibacterial, Antioxidant and Anti-Inflammatory Effects of Senecio asperulus and Gunnera perpensa from Mohale's Hoek, Lesotho</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gunnera perpensa</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Senecio asperulus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">730-739</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Traditional medicinal plants have been widely used to treat or manage various ailments for centuries in Lesotho. With an increase in multi drug resistance and undesired adverse events to current drugs challenges, there is a need for alternative drugs. &lt;strong&gt;Aim:&lt;/strong&gt; In this study we aimed at the investigation of antibacterial, antioxidant and anti-inflammatory effects of &lt;em&gt;Senecio asperulus&lt;/em&gt; and &lt;em&gt;Gunnera perpensa&lt;/em&gt; roots extracted in three solvents of different polarities. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Antibacterial activity was determined using the disc diffusion method, while antioxidant activity was determined using free radical scavenging of 2,2-diphenyl-1-picrylhydrazyl and the ferric reducing antioxidant power assay. The Lipopolysaccharide (LPS) stimulated RAW 264.7 mouse macrophage &lt;em&gt;in vitro&lt;/em&gt; model was used to evaluate the anti-inflammatory activity of both plants. Resveratrol was used as a positive control. &lt;strong&gt;Results:&lt;/strong&gt; Methanol extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; inhibited microbial growth even at the lowest concentration of 50 μg/ml. &lt;em&gt;Senecio asperulus &lt;/em&gt;dichloromethane extract was active on most bacteria with MIC’s between 50 μg/ml and 500 μg/ml. However, the water and methanol extracts of &lt;em&gt;Gunnera perpensa&lt;/em&gt; had no activity against all organisms tested. Aqueous extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; and &lt;em&gt;Gunnera perpensa&lt;/em&gt; showed free radical scavenging activity yielding EC&lt;sub&gt;50&lt;/sub&gt; values of 100 μg/ml and 25 μg/ml, respectively. The aqueous extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; showed moderate anti-inflammatory activity from 50 to 200 μg/ml. while the methanol extract was at 200 μg/ml and with no cytotoxicity. No anti-inflammatory activity was observed from all&lt;em&gt; Gunnera perpensa&lt;/em&gt; extracts using LPS-induced macrophages, this suggests that this species may be using other mechanisms for anti-inflammatory activity. &lt;strong&gt;Conclusion: &lt;/strong&gt;The antibacterial, antioxidant and anti-inflammatory activities observed from water extracts of &lt;em&gt;Senecio asperulus&lt;/em&gt; support its ethnomedicinal use for the management of inflammation related diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">730</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mfengwana Polo-Ma-Abiele H&lt;sup&gt;1,*&lt;/sup&gt;, Mashele Samson S&lt;sup&gt;2&lt;/sup&gt;, Manduna Idah T&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Health Sciences, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Unit for Drug Discovery Research, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Applied Food Security and Biotechnology, Central University of Technology, Free State, Private Bag X20539, Bloemfontein, 9300, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ika Rahayu</style></author><author><style face="normal" font="default" size="100%">Pamela Hendra Heng</style></author><author><style face="normal" font="default" size="100%">Kris H Timotius</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Antioxidant Properties and α-Glucosidase Inhibition of Combined Leaf Infusions from Psidium guajava L., Syzygium polyanthum L., and Annona muricata L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anonna muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf infusion</style></keyword><keyword><style  face="normal" font="default" size="100%">Psidium guajava</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergism</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium polyanthum</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1269-1277</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Guava (&lt;em&gt;P. guajava&lt;/em&gt;), bay (&lt;em&gt;S. polyanthum&lt;/em&gt;), and soursop (&lt;em&gt;A. muricata&lt;/em&gt;) known as natural medicine. Limited report is available on their antioxidant and α-glucosidase inhibitory activities of leaf infusion. The aims of this research were to compare the antioxidant and α-glucosidase inhibitory activities of leaf infusion from guava, bay, and either as individual or combined infusions, and to analyze the chemical composition of the leaf infusion. &lt;strong&gt;Methods:&lt;/strong&gt; Air dried leaf powder of guava, bay and soursop were infused separately with boiled aquadest. The infusions were analyzed for their antioxidant activity against DPPH. The α-glucosidase inhibitory assay was conducted against α-glucosidase from &lt;em&gt;Saccharomyces cerevisiae. &lt;/em&gt;Then the infusions scanned with UV-Vis spectroscopy and analyzed with LC-MS. The synergism activities of the combined infusion were measured. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activities of leaf infusions of guava and bay showed a comparable result IC&lt;sub&gt;50&lt;/sub&gt; 12.53 ± 0.55 and 10.76 ± 0.20 μg GAE/mL, but the infusion of soursop showed lower (IC&lt;sub&gt;50&lt;/sub&gt; 19.77 ± 0.35 μg GAE/mL) than BHT as positive control (11.6 ± 0.31 μg GAE/mL). If soursop infusion was not added, then the mixture of the guava and bay infusion showed an antioxidative synergistic effect. The α-glucosidase inhibitory activities of the guava, bay and soursop infusion (0.083 ± 0.01; 0.025 ± 0.007; 0.533 ± 0.039 μg GAE/mL, respectively) were stronger than acarbose (1285 ± 148 μg/mL). The α-glucosidase inhibitory activities of the combined infusions showed a synergistic effect. The main constituents of the guava infusion were identified tentatively as chrysin and caffeoylquinic acid, for the bay infusion it was caffeoylquinic, and for the soursop infusion it was luteolin. &lt;strong&gt;Conclusions:&lt;/strong&gt; There is a significant synergism of antioxidant activity of Guava and Bay mixture. The combined infusion of Bay and Soursop or Guava and Soursop showed antagonistic effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1269</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ika Rahayu&lt;sup&gt;1&lt;/sup&gt;, Pamela Hendra Heng&lt;sup&gt;2&lt;/sup&gt;, Kris H. Timotius&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Universitas Kristen Krida Wacana (UKRIDA), Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Psychology, Universitas Tarumanagara, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elly Wardani</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Influence of Extraction on the Yield, Phytochemical and LCMS Profile from Standardized Kemuning Leaf (Murraya paniculata (L.) Jack)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Murraya paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Standardization of extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1455-1462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Mahanimbine alkaloid is carbazole alkaloids found in kemuning (&lt;em&gt;Murraya paniculata &lt;/em&gt;(L.) Jack) potentially as antihyperlipidemia. Chemical compounds from plants can be obtained by extraction. The aim of this study was to determine influence of extraction solvents on the yield, phytochemistry and LCMS profiles from standardized kemuning to produce safe and quality medicinal raw materials.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;The study was used kinds of ethanol concentration with different polarity as a solvent for extraction. Solvent 40%, 70% and 96% of ethanol were used for maceration of simplicia from Bogor, West Java. The extract obtained was evaluated for the content of alkaloid compounds for LCMS then extracts were selected to be proceed to standardized extract quality.&lt;strong&gt; Results: &lt;/strong&gt;The LCMS results showed that all 40%, 70% and 96% ethanol extracts contained Candidate Mass 354,19014 compounds which were thought to be e alkaloids based on the m/z value. Phytochemical screening in all extracts contained alkaloid compounds, flavonoids, saponins, tannins and steroids/triterpenoids. 96% ethanolic extract contained non-specific parameter such as content of compounds soluble in water 22,73%, soluble in ethanol 17,37%, drying down 9,10%, water content 18,36%, total ash content 4,18%, the yield of extracts was 33,45%, microbial contamination &amp;lt;3,0.10&lt;sup&gt;4&lt;/sup&gt; (7,0.10&lt;sup&gt;4&lt;/sup&gt;) colony/g and mold yeast number 0 colony/g. The total gravimetric alkaloid level was 1,031%. &lt;strong&gt;Conclusions:&lt;/strong&gt; 96% ethanolic extract of kemuning contains mahanimbine alkaloids and has met the standard quality requirements of extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elly Wardani&lt;sup&gt;1&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;2&lt;/sup&gt;, Abdul Mun’im&lt;sup&gt;3&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;4,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduated Program of faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, , West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Bioanalysis, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, , West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Phytochymestry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, , West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, , West Java 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sendangratri</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effects of Different Varieties of Sweet Potato (Ipomoea batatas L.) Tubers Extracts on Lipoxygenase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas L</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato tubers</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoid contents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1195-1198</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sweet potatoes (&lt;em&gt;Ipomoea batatas&lt;/em&gt; L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to determine IC&lt;sub&gt;50 &lt;/sub&gt;value of sweet potato tubers extracts in inhibiting lipoxygenase activity. &lt;strong&gt;Methods:&lt;/strong&gt; Dried tubers of sweet potato were macerated with ethanol 70%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC&lt;sub&gt;50&lt;/sub&gt; value and total flavonoid contents obtained from each extracts were analyzed statistically. &lt;strong&gt;Results: &lt;/strong&gt;IC&lt;sub&gt;50 &lt;/sub&gt;value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Total flavonoid contents and IC&lt;sub&gt;50&lt;/sub&gt; values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sendangratri&lt;sup&gt;1&lt;/sup&gt;, Rosita Handayani&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nina Handayani</style></author><author><style face="normal" font="default" size="100%">Hidayat Sujuti</style></author><author><style face="normal" font="default" size="100%">Nur Permatasari</style></author><author><style face="normal" font="default" size="100%">Achmad Rudijanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Niacin Regulates Glucose Reactive Protein (GRP78), Protein Carbonyl Content (PCC) and Malondialdehyde (MDA) in the Hyperglycemic Human Lens Epithelial Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetic cataract</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">GRP78</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Niacin</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">PCC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">8-11</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Niacin is part of the chemical structure of coenzymes nicotinamide adenine nucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Previous studies suggested that a high niacin intake could decrease the prevalence of cataracts, which may delay the onset of diabetic cataract. &lt;strong&gt;Aim:&lt;/strong&gt; The aim of this study was to evaluate the effect of niacin on the hyperglycemia-induced osmotic stress and oxidative stress in human lens epithelial cells. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Human lens epithelial cells were cultured in a high glucose condition. Oxidative stress markers, including malondialdehyde (MDA), protein carbonyl content (PCC) and glucose reactive protein (GRP), were measured using TBARS analysis (MDA) and ELISA (PCC and GRP) after 72 h incubation.&lt;strong&gt; Results:&lt;/strong&gt; The MDA levels increased after high glucose administration relative to that in the control group (p &amp;lt;0.05). Further, the groups that were co-treated with niacin showed decrease in the MDA levels for all doses of niacin and the lowest mean MDA level was obtained with 100 μM niacin. There was a decrease in the PCC levels for all doses, whereas the lowest mean PCC level was observed at a 100 μM niacin dose. The GRP levels increased after high glucose administration as compared with the control group. Also, the groups that were co-treated with niacin exhibited statistically significant reduction.&lt;strong&gt; Conclusion:&lt;/strong&gt; These results suggest that niacin can inhibit the osmotic stress and oxidative stress which may lead to the progression of a diabetic cataract. Also, it may maintain lens transparency by acting as a precursor for glutathione biosynthesis and an antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">8</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Nina Handayani&lt;sup&gt;1,2,*&lt;/sup&gt;, Hidayat Sujuti&lt;sup&gt;3&lt;/sup&gt;, Nur Permatasari&lt;sup&gt;4&lt;/sup&gt;, Achmad Rudijanto&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Endocrinology and Metabolic Disease, Department of Internal Medicine, Faculty of Medicine, Brawijaya University, Saiful Anwar Hospital Malang, Malang, East Java,INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S Dhanalakshmi</style></author><author><style face="normal" font="default" size="100%">C N Hemalatha</style></author><author><style face="normal" font="default" size="100%">Sai Ramya Bharathi</style></author><author><style face="normal" font="default" size="100%">C Dhivya</style></author><author><style face="normal" font="default" size="100%">S Vanishree</style></author><author><style face="normal" font="default" size="100%">V Rekha</style></author><author><style face="normal" font="default" size="100%">V Vijayalakshmi</style></author><author><style face="normal" font="default" size="100%">A Hari priya</style></author><author><style face="normal" font="default" size="100%">Sai Monisha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Optimization Method for Determination of Swelling Factor Linum usitatissimum Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Formulation parameter</style></keyword><keyword><style  face="normal" font="default" size="100%">Seed</style></keyword><keyword><style  face="normal" font="default" size="100%">Swelling index</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">936-943</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; Aspire of the investigation is to amend the method for determination of swelling factor of seeds, so it can be determined to optimize the minimum errors which will be reproducible. Swelling factor is play key role if the phytoconsitituent rich in mucilage and polysaccharide which constitute a diverse class of biological macromolecules. &lt;strong&gt;Background:&lt;/strong&gt; Sugar molecules play a broad range of physiochemical properties which are widely used for applications in Pharmacy and the present investigation work is related to determine the effect of parameters such as quantity of seed, volume and nature of solvent, time interval of agitation, time of measurement of result, Effect of quantity of seeds on swelling factor determination. Solvent Optimized technic gives superlative results over IP method. &lt;strong&gt;Methods:&lt;/strong&gt; The swelling factor of &lt;em&gt;Linum usitatissimum&lt;/em&gt; was evaluated by using different polar to non-polar solvents by using the standard procedure. During the determination, the role of physical parameter were calculated by comprising the swelling factor with agitation and temperature. &lt;strong&gt;Results:&lt;/strong&gt; According to the observations, the lower concentration levels of swelling index used as an alternative binder to starch. keeping one parameter as variable while all other parameters constant, it was observed that the swelling index of gives better results using the solvents plain distilled water, seeds moistened with alcohol. It was also observed that agitation at every three hours till the process of 24 hours is maintained would give better results, keeping one parameter as variable while all other parameters constant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">936</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;S Dhanalakshmi&lt;sup&gt;1,&lt;/sup&gt;*, C N Hemalatha&lt;sup&gt;2&lt;/sup&gt;, Sai Ramya Bharathi&lt;sup&gt;3&lt;/sup&gt;, C Dhivya&lt;sup&gt;4&lt;/sup&gt;, S Vanishree&lt;sup&gt;5&lt;/sup&gt;, V Rekha&lt;sup&gt;6&lt;/sup&gt;, V Vijayalakshmi&lt;sup&gt;7&lt;/sup&gt;, A Hari priya&lt;sup&gt;8&lt;/sup&gt;, Sai Monisha&lt;sup&gt;9&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Dr.M.G.R Educational and Research Institute, Velappanchavadi, Chennai – 600 077, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Srinivasa Naidu Parijatham Kanchana</style></author><author><style face="normal" font="default" size="100%">Agnel Arul John Nayagam</style></author><author><style face="normal" font="default" size="100%">Sandra Horta</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile of Root and Stem of Indigofera Tirunelvelica Sanjappa</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloid</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigofera tirunelvelica Sanjappa</style></keyword><keyword><style  face="normal" font="default" size="100%">Root</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1580-1586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The focus on herbal plants as medicine is increasing rapidly because of their efficacy and less side effects. The medicinal plants are great alternative as they are renewable and non exhaustive resources. In India these medicinal plants have been part of the people’s life dating back from centuries. &lt;strong&gt;Objectives:&lt;/strong&gt; The present study is aimed to evaluate anatomical characterization of stem and root of &lt;em&gt;Indigofera tirunelvelica&lt;/em&gt; Sanjappa for the first time which can be used in the identification and standardisation of &lt;em&gt;Indigofera tirunelvelica&lt;/em&gt; Sanjappa. &lt;strong&gt;Results: &lt;/strong&gt;The stem and root of the plant were evaluated for their microscopic features. In that histochemical localisation of secondary metabolites and transverse section of stem and root were studied. The histochemical localisation result reveals the presence of terpenoids, alkaloids, flavonoids and lignin were found in epidermal, cortical and xylem regions of the stem. Alkaloids, Terpenoids, phenols and lignin were found in the different areas of root. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study thus emphasis the potentiality of the plant as a drug.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1580</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Srinivasa Naidu Parijatham Kanchana&lt;sup&gt;1&lt;/sup&gt;, Agnel Arul John Nayagam&lt;sup&gt;2,&lt;/sup&gt;*, Sandra Horta&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, St, Francis College for Women (Autonomous), Hyderabad, Telangana, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;PG and research Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous), Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Biochemistry, St, Francis College for Women (Autonomous), Hyderabad, Telangana, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Endang Hanani</style></author><author><style face="normal" font="default" size="100%">Sri Harsodjo Wijono Soewandi</style></author><author><style face="normal" font="default" size="100%">Hayati</style></author><author><style face="normal" font="default" size="100%">Nellysa Revita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical and Preliminary Phytochemical Evaluation of Cordia sebestena L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Boraginaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromatography Profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1100-1105</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cordia sebestena&lt;/em&gt; L. belongs to family Boraginaceae is commonly known as “Geiger Tree” in Indonesia, it is generally found in Indonesia included Jakarta, and many other countries. Some researchers have revealed the presence of several pharmacology activities. Thus this study is an attempt to present an overview of pharmacognostic and phytochemical evaluation reported on this plant. &lt;strong&gt;Objective: &lt;/strong&gt;In the present investigation, various pharmacognostic standards have been investigated to prove the authenticity of the plant for the claimed traditional uses. This will help in the identification of powder drug prior to using in medicine. &lt;strong&gt;Methods:&lt;/strong&gt; Macroscopic, microscopic and physicochemical evaluation, of the drug was performed using standardized procedures as mentioned in the WHO and Indonesian Herb Pharmacopoeia guidelines.Thin layer chromatography profile was done using some different mobile phase system to the identification of the drug. &lt;strong&gt;Results: &lt;/strong&gt;The physicochemical parameters such as moisture content, ethanol- and water-soluble extractive, total ash, acidinsoluble ash value, were determined. Phytochemical screening showed the presence of alkaloids, flavonoids, phenols, saponins, tannins, steroids, terpenoids in the ethanolic extracts of leaf of this plant. The TLC profile of &lt;em&gt;n&lt;/em&gt;-hexane, dichloromethane and methanol extract were carried out 5, 7 and 2 spots respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study on pharmacognostical, physicochemical and phytochemical standards could be useful information for authentication and preparation monograph for &lt;em&gt;C.sebestena&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1100</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Endang Hanani&lt;sup&gt;1,2,&lt;/sup&gt;*, Sri Harsodjo Wijono Soewandi&lt;sup&gt;1,2&lt;/sup&gt;, Hayati&lt;sup&gt;1,2&lt;/sup&gt;, Nellysa Revita&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. HAMKA, Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdullahi Aliyu Ebbo</style></author><author><style face="normal" font="default" size="100%">Dahiru Sani</style></author><author><style face="normal" font="default" size="100%">Mohammed Musa Suleiman</style></author><author><style face="normal" font="default" size="100%">Abubakar Ahmed</style></author><author><style face="normal" font="default" size="100%">Adamu Zoaka Hassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Composition, Proximate Analysis and Antimicrobial Screening of the Methanolic Extract of Diospyros mespiliformis Hochst ex a. Dc (ebenaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Diospyros mespiliformis</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Proximate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">362-368</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; &lt;em&gt;Diospyros mespiliformis&lt;/em&gt; is one plant used by the natives for the treatment of certain diseases including wounds. In this present study, preliminary screening of the methanolic leaf extract of &lt;em&gt;D. mespiliformis&lt;/em&gt; was carried out for its phytochemical and proximate constituents in addition to investigating its antimicrobial activity against four bacteria species. &lt;strong&gt;Methodology:&lt;/strong&gt; Preliminary phytochemical and proximate analysis were carried out using standard methods. The antimicrobial activity was conducted using the whole in-plate and broth serial micro dilution assays on two Gram positive bacteria (&lt;em&gt;Staphylococcus aureus, Salmonella typhymurium&lt;/em&gt;) and two Gram negative bacteria (&lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and Escherichia coli). &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening showed the presence of alkaloids, tannins, saponins, glycosides, anthraquinones, flavonoids and volatile oil. Similarly, preliminary proximate analysis of the root, bark and leaf extracts of &lt;em&gt;D. mespiliformis&lt;/em&gt; exerts revealed the presence of carbohydrate, crude protein, moisture, lipid and nitrogen, ash and fibre. The extract demonstrated greater inhibitory activity on &lt;em&gt;P. aeruginosa, S. aureus&lt;/em&gt; and &lt;em&gt;E. coli&lt;/em&gt; (MIC=156.25 μg/ml) than on S. typhymurium (MIC=312.5 μg/ml). &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings revealed that the crude methanolic extract of &lt;em&gt;D. mespiliformis&lt;/em&gt; and its fractions demonstrated broad spectrum antimicrobial activity in a dose dependent manner.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abdullahi Aliyu Ebbo&lt;sup&gt;1,2,*&lt;/sup&gt;, Dahiru Sani&lt;sup&gt;2&lt;/sup&gt;, Mohammed Musa Suleiman&lt;sup&gt;2&lt;/sup&gt;, Abubakar Ahmed&lt;sup&gt;3&lt;/sup&gt;, Adamu Zoaka Hassan&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, NIGERIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, NIGERIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Ahmadu Bello University Zaria, NIGERIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Veterinary Surgery, Faculty of Veterinary Medicine, Ahmadu Bello University Zaria, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nguyen Van Long</style></author><author><style face="normal" font="default" size="100%">Bui Thi Thu Ha</style></author><author><style face="normal" font="default" size="100%">Anh Vu Tuan</style></author><author><style face="normal" font="default" size="100%">Hoang Van Luong</style></author><author><style face="normal" font="default" size="100%">Nguyen Tung Linh</style></author><author><style face="normal" font="default" size="100%">Thanh Chu Duc</style></author><author><style face="normal" font="default" size="100%">Phung Cao Dai</style></author><author><style face="normal" font="default" size="100%">Chul Soon Yong</style></author><author><style face="normal" font="default" size="100%">Chu Van Men</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytosomal Nanoparticles Preparation of Curcuminoids to Enhance Cellular Uptake of Curcuminoids on Breast Cancer Cell Line MCF-7</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular uptake</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcuminoids</style></keyword><keyword><style  face="normal" font="default" size="100%">FACS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytosome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1037-1045</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Curcuminoids, the bioactive compounds extracted from &lt;em&gt;Curcuma longa &lt;/em&gt;consisting of Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), have shown promising biological effects, including anticancer activity. This study sought to prepare a physically stable phytosomal nanoparticles of curcuminoids (Curs-Phyto) to facilitate uptake of curcuminoids on breast cancer cells line, and further increase the cytotoxicity against cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The evaporation combined extrusion technique was employed to prepare phytosomal curcuminoids nanoparticles. The interaction between curcuminoids and phospholipid by a hydrogen bond was confirmed by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), fourier transform infrared (FT-IR), and &lt;sup&gt;1&lt;/sup&gt;H nuclear magnetic resonance (&lt;sup&gt;1&lt;/sup&gt;H-NMR). Their physicochemical characterizations and stability in simulated gastric and intestinal media were investigated. The effects of Curs-Phyto on MCF-7 cells were evaluated by flow cytometry, MTS assay and cell cycle analysis. &lt;strong&gt;Results:&lt;/strong&gt; We found that the Curs-Phyto were formed at a spherical shape with good size (~ 180 nm), a narrow size distribution (PDI &amp;lt; d0.2), high complexation rate (~ 87%, 95%, and 90% for BDMC, DMC, and CUR respectively) and high loading capacity of curcuminoids. More importantly, the Curs-Phyto showed the increased cellular uptake and enhanced cytotoxicity against MCF- 7 cancer cells, compared to free curcuminoids. &lt;strong&gt;Conclusion: &lt;/strong&gt;These results indicated that the phytosome could be a promising oral delivery system for curcuminoids for cancer treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nguyen Van Long&lt;sup&gt;1,#&lt;/sup&gt;, Bui Thi Thu Ha&lt;sup&gt;1,#&lt;/sup&gt;, Anh Vu Tuan&lt;sup&gt;1&lt;/sup&gt;, Hoang Van Luong&lt;sup&gt;1&lt;/sup&gt;, Nguyen Tung Linh&lt;sup&gt;1&lt;/sup&gt;, Thanh Chu Duc&lt;sup&gt;1&lt;/sup&gt;, Phung Cao Dai&lt;sup&gt;2&lt;/sup&gt;, Chul Soon Yong&lt;sup&gt;2&lt;/sup&gt;, Chu Van Men&lt;sup&gt;1,#&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Biomedicine and Pharmacy, Vietnam Military Medical University, 222-Phung Hung Street, Ha Dong District, Hanoi, VIETNAM.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmaceutics, College of Pharmacy, Yeungnam University, 214-1 Dae-Dong, Gyeongsan 712-749, REPUBLIC OF KOREA. #These authors contributed equally to this work.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rezqi Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential Herbs of Medicinal Forests from Central Kalimantan as a Inhibitor of Staphylococcus aureus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inhibitory test</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal forest</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicines</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">740-744</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Central Kalimantan is one of the largest provinces in Indonesia with a wealth of medicinal herbaceous plant species. This province was the origin of various medicinal plants such as tabat barito, akar kuning, pasak bumi and some other medicinal plants that were useful for human health. &lt;strong&gt;Methods: &lt;/strong&gt;This paper explain about inhibitory test extracts etanol of Hati Tanah (&lt;em&gt;Angiotepris&lt;/em&gt; Sp) tubers and Sangkareho leaves (&lt;em&gt;Callicarpa longifolia&lt;/em&gt; Lam.) in &lt;em&gt;Staphylococcus aureus &lt;/em&gt;bacteria with concentration 1%, 5%, 10%, and 15%. Both plants has been utilized by the community as a traditional medicine to treat minor to moderate injuries such as postpartum. &lt;strong&gt;Results:&lt;/strong&gt; The results for extract Hati Tanah was 15.63 mm, 16.97 mm, 25.42 mm, 28.40 mm and the results for and Sangkareho leaves was 1 mm, 2.68 mm, 3.9 mm, 6.2 mm. Inhibitory test studies have also been performed on the N-Butanol fraction from ethanol extract Hati Tanah tubers of the soil at the same concentrations and bacteria. The inhibited zone results was 15.65 mm, 23.20 mm, 24.15 mm, 26.25 mm. &lt;strong&gt;Conclusion: &lt;/strong&gt;Medicinal forest plants origin of Central Kalimantan is Hati Tanah tubers and Sangkareho leaves has potential as a traditional medicine in inhibiting and killing &lt;em&gt;Staphylococcus aureus &lt;/em&gt;bacteria.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">740</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rezqi Handayani* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Health Science, Universitas Muhammadiyah Palangkaraya, Central Borneo, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Robert Palomino-De-La-Gala</style></author><author><style face="normal" font="default" size="100%">Hugo Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Cristian Aguilar-Carranza</style></author><author><style face="normal" font="default" size="100%">Jaime Martínez-Heredia</style></author><author><style face="normal" font="default" size="100%">Edwin Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Carlos García-Bustamante</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez- Asmat</style></author><author><style face="normal" font="default" size="100%">Lester Dominguez-Huarcaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baccharis genistelloides</style></keyword><keyword><style  face="normal" font="default" size="100%">Benign prostatic hyperplasia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Dutasteride</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">858-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men, with oxidative stress postulated as an important factor in its development.&lt;strong&gt; Objective:&lt;/strong&gt; To evaluate the protective effect of the association of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG) on benign prostatic hyperplasia in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sixty-six male rats were randomized into groups: 1) Inductor Group: Testosterone enanthate (ET) 25 mg/Kg on days 8 and 14 intramuscularly. 2) Group P80: Polysorbate-80 3% 10 mL / Kg. 3) Positive Group: ET + Dutasteride (DU) 0.5 mg / Kg, 4) ET + ChS 250, 5) ET + ChS 500, 6) ET + BaG250, 7) ET + BaG 500, 8) ET + ChS 250 + BaG 250, 9) ET + ChS 500 + BaG 500, 10) ET + ChS 250 + BaG 500, 11) ET + ChS 500 + BaG250. PSA, nitric oxide (NO) and malondialdehyde (MDA), prostate dimensions by ultrasound and histopathological findings were quantified as main markers. &lt;strong&gt;Results:&lt;/strong&gt; Lower levels of NO, MDA and PSA were observed in all groups treated with extract compared to the Inductor group (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.01), with the reductive capacity of the mixture ChS 250 + BaG 500 and ChS 500 + BaG 250 compared with Dutasteride (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). The volume of the prostate was lower in the Dutasteride, P80 and ChS250 + BaG500 groups compared to the inducer (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). Regarding the histopathological study, it was observed that the association of variable doses (ChS250 + BaG500 and ChS500 + BaG250) had a better protective effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; Under experimental conditions, the association of the extracts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; and &lt;em&gt;Baccharis genistelloides &lt;/em&gt;has an effect in the protection of BPH induced with testosterone, which could be linked to its antioxidant capacity of the extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">858</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Robert Palomino-De-La- Gala&lt;sup&gt;1,2&lt;/sup&gt;, Hugo Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Rojas-Armas&lt;sup&gt;1,2&lt;/sup&gt;, Cristian Aguilar-Carranza&lt;sup&gt;3&lt;/sup&gt;, Jaime Martínez-Heredia&lt;sup&gt;1,2&lt;/sup&gt;, Edwin Cieza-Macedo&lt;sup&gt;1,2&lt;/sup&gt;, Carlos García- Bustamante&lt;sup&gt;1,2&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;4&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Roberto Chávez- Asmat&lt;sup&gt;6&lt;/sup&gt;, Lester Dominguez-Huarcaya&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Clinical Research, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Instituto Nacional Cardiovascular, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Physiology laboratory. Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imad M Al-Ani</style></author><author><style face="normal" font="default" size="100%">Norsidah Ku-Zaifah</style></author><author><style face="normal" font="default" size="100%">Fakhria A. Al-Joufi</style></author><author><style face="normal" font="default" size="100%">Rafidah H.Mokhtar</style></author><author><style face="normal" font="default" size="100%">Norlelawati A. Talib</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eurycoma Longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Fat-Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Seminiferous Tubules Tongkat Ali</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">808-811</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether &lt;em&gt;Eurycoma longifolia&lt;/em&gt; (EL) is able to ameliorate these effects. &lt;strong&gt;Methods:&lt;/strong&gt; Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal’s testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12&lt;sup&gt;th &lt;/sup&gt;weeks and the testes samples were processed for histological examination&lt;strong&gt; Results: &lt;/strong&gt;The testosterone level was significantly increased (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">808</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Imad M Al-Ani&lt;sup&gt;1&lt;/sup&gt;, Norsidah Ku-Zaifah&lt;sup&gt;2&lt;/sup&gt;, Fakhria A. Al- Joufi&lt;sup&gt;3&lt;/sup&gt;, Rafidah H.Mokhtar&lt;sup&gt;4&lt;/sup&gt;, Norlelawati A. Talib&lt;sup&gt;5&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;6,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dentistry, Al-Hikmah University College, Al-Yarmook, Baghdad, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Pharmacy, Al Jouf University, Aljouf, Skaka KSA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Fundamental Dental and Medical sciences, Kulliyyah of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dwitiyanti</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Molecular Docking of Vitexin in Binahong (Anredera cordifolia (Ten.) Steenis) Leaves Extract on Glibenclamide-CYP3A4 Interaction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">Glibenclamide</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitexin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1471-1476</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Diabetes Mellitus is a disease that has a high prevalence in Indonesia. About 90-95% of all diabetes cases were caused by the failure or incapability of insulin target cells to respond to the insulin in normal state. The use of glibenclamide antidiabetic drugs with herbs has been occurred frequently in the community. Vitexin, one of active compounds in binahong (&lt;em&gt;Anredera cordifolia&lt;/em&gt; (Ten.) Steenis) leaves, has been known to have an antidiabetic effects. This study aimed to determine the molecular docking interaction of glibenclamide and vitexin in binahong leaves against CYP3A4 as antidiabetic drug. &lt;strong&gt;Method: &lt;/strong&gt;Molecular docking methods were carried out using Autodock Vina software and interaction was visualized using discovery studio. &lt;strong&gt;Results: &lt;/strong&gt;The study indicated that the value of glibenclamide complex free energy with CYP3A4 was -3.2 kcal/mol and the stability has increasing to -4.4 kcal/mol after docked with vitexin. The glibenclamide and vitexin complexes had 7 Pi alkyl hydrophobic bonds, 1 hydrocarbon hydrogen bond 1 Pi-cation electrostatic interactions, other interactions between Pi bond and sulfur atoms in cysteine amino acid residues, Pi bond interactions in phenylalamin aromatic groups with electron pairs oxygen atom. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study concluded that vitexin could improve glibenclamide stability.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1471</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dwitiyanti&lt;sup&gt;1&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;3&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;4,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduated Program of faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Bioanalysis, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java 16424, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Augustine A. Ahmadu</style></author><author><style face="normal" font="default" size="100%">Bilqis A. Lawal</style></author><author><style face="normal" font="default" size="100%">Anas Haruna</style></author><author><style face="normal" font="default" size="100%">Lukman Mustapha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Tetrahydroxy Flavone from Acacia auriculiformis A. Cunn Ex Benth. (Fabaceae) with Novel Kinase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CDK9</style></keyword><keyword><style  face="normal" font="default" size="100%">DYRK1A</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein kinases</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetrahydroxyflavone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">559-563</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The decoctions of the bark of &lt;em&gt;Acacia auriculiformis&lt;/em&gt; are used in folkloric medicine to relieve pain and inflammation and as remedy for cancer. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this work is to screen the extract and fractions of &lt;em&gt;Acacia auriculiformis&lt;/em&gt; for protein kinase inhibitory activity and also to isolate and characterize chemical entities from this plant and evaluate their protein kinase inhibitory activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Kinase inhibitory activity were assayed in appropriate buffer, with either protein or peptide as substrate in the presence of 15&lt;em&gt;μ&lt;/em&gt;M (33-P) ATP (3,000Ci/mmol; 10mCi/ml) in a final volume of 30&lt;em&gt;μ&lt;/em&gt;L. Controls were performed with appropriate dilutions of dimethyl sulphoxide. A portion of the Chloroform extract, ethylacetate and n-butanol soluble fractions of the stem bark of &lt;em&gt;Acacia auriculiformis&lt;/em&gt; were screened against a panel of disease-related protein kinases and the active fractions was tested over a wide range of concentrations from 0.016 to 50&lt;em&gt;μ&lt;/em&gt;g/ml and the IC&lt;sub&gt;50&lt;/sub&gt; values were determined from the dose response curve. The most active fraction was subjected to chromatographic separation using Silica gel G column chromatography and sephadex LH-20 to give compound I. The structure of the isolated compound was elucidated using NMR and LCMS. &lt;strong&gt;Results:&lt;/strong&gt; The Primary screening of the extract and fractions showed that the chloroform extract was inactive against all the protein kinases investigated, while the ethylacetate and n-butanol soluble fractions inhibited all the protein kinases tested. Compound I also inhibited all the kinases tested. The IC&lt;sub&gt;50&lt;/sub&gt; of the active fractions and compound were also evaluated. Ethylacetate fraction inhibited all the kinases tested with the highest activity against Haspine kinase with IC&lt;sub&gt;50&lt;/sub&gt; of 1.0 &lt;em&gt;μ&lt;/em&gt;g/ml, while n-butanol also gave the highest activity against Haspine kinase with 1C&lt;sub&gt;50 &lt;/sub&gt;of 1.3 &lt;em&gt;μ&lt;/em&gt;g/ml. From the active ethylacetate fractions 3, 4’, 7, 8- tetrahydroxy flavone was isolated. The Compound exhibited the maximal activity against DYRK1A kinase with an IC&lt;sub&gt;50&lt;/sub&gt; of 2.05 &lt;em&gt;μ&lt;/em&gt;g/ml followed by CDK9 with an IC&lt;sub&gt;50&lt;/sub&gt; of 2.28 &lt;em&gt;μ&lt;/em&gt;g/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; 3, 4’,7, 8- tetrahydroxy flavone was isolated was found to be a DYRK1A and CDK9 inhibitor which might justify the anticancer potential of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">559</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Augustine A. Ahmadu&lt;sup&gt;1,*&lt;/sup&gt;, Bilqis A. Lawal&lt;sup&gt;2&lt;/sup&gt;, Anas Haruna&lt;sup&gt;1&lt;/sup&gt;, Lukman Mustapha&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharm and Medicinal Chemistry, Kaduna State University, Tafawa Balewa Road, Kabala Costain, Kaduna, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy and Drug Development, University of Ilorin, Ilorin, Kwara, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramadanil</style></author><author><style face="normal" font="default" size="100%">Damry</style></author><author><style face="normal" font="default" size="100%">Rusdi</style></author><author><style face="normal" font="default" size="100%">Baharuddin Hamzah</style></author><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Traditional Usages and Phytochemical Screenings of Selected Zingiberaceae from Central Sulawesi, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Central Sulawesi Indonesia</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional usages</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiberaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">505-510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Zingiberaceae&lt;/em&gt; is one of the significant components of the herbaceous ground flora of Southeast Asia tropical forests. This family includes some medicinally important species, in particular the members of genera of&lt;em&gt; Alpinia, Curcuma&lt;/em&gt;, &lt;em&gt;Etlingera&lt;/em&gt; and &lt;em&gt;Zingiber&lt;/em&gt; (Van Balgooy, 2001). &lt;strong&gt;Objective:&lt;/strong&gt; to identify the traditional usages and evaluate for phytochemical screening of selected&lt;em&gt; Zingiberaceae&lt;/em&gt; from Central Sulawesi, Indonesia. &lt;strong&gt;Material and Methods:&lt;/strong&gt; &lt;em&gt;Zingiberaceae&lt;/em&gt; samples were collected from the Lore Lindu National Park (LLNP), Central Sulawesi Indonesia and its surroundings and evaluated for their phytochemical contents by using TLC method with particular spraying reagents. &lt;strong&gt;Results:&lt;/strong&gt; the plants were used by the local ethnics for different daily and medicinal purposes. All part of each selected species of &lt;em&gt;Zingiberaceae&lt;/em&gt; contain flavonoid, tannins, saponins, triterpenoid and alkaloid although steroids were only found in the leaves of &lt;em&gt;Etlingera flexuosa&lt;/em&gt;, &lt;em&gt;Curcuma mangga&lt;/em&gt; and &lt;em&gt;Alpinia galanga.&lt;/em&gt; Alkaloids were only found in the rhyzome of &lt;em&gt;Etlingera flexuosa&lt;/em&gt;, &lt;em&gt;Curcuma aerugynosa, Zingiber montanum&lt;/em&gt;. Besides it was also detected in leaves of both&lt;em&gt; Alpinia rubricaulis&lt;/em&gt; and &lt;em&gt;Etlingera acanthoides&lt;/em&gt;. Additionally, Alkaloids were also discovered in the stem of &lt;em&gt;Ammomum aculeata&lt;/em&gt;,&lt;em&gt; Alpinia galanga&lt;/em&gt; and &lt;em&gt;Curcuma mangga&lt;/em&gt;.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">505</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ramadanil&lt;sup&gt;1,*&lt;/sup&gt;, Damry&lt;sup&gt;2&lt;/sup&gt;, Rusdi&lt;sup&gt;2&lt;/sup&gt;, Baharuddin Hamzah&lt;sup&gt;3&lt;/sup&gt;, Muhammad Sulaiman Zubair&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathemathics and Natural Sciences, Tadulako University, Palu City, Central Sulawesi 94148, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Animal Husbandry, Faculty of Animal Husbandry and Fishery, Tadulako University, Palu City, Central Sulawesi 94148, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Education Chemistry, Faculty of Teaching and Education, Tadulako University, Palu City, Central Sulawesi 94148, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, Faculty of Mathemathics and Natural Sciences, Tadulako University, Palu City, Central Sulawesi 94148, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Novi Yantih</style></author><author><style face="normal" font="default" size="100%">Alfadella Methananda</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Wahono Sumaryono</style></author><author><style face="normal" font="default" size="100%">Lestari Rahayu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Validation of High-Performance Liquid Chromatography for Determination of Bromelain in Pineapple (Ananas comosus (L) Merr) Water</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bromelain</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pineapple water</style></keyword><keyword><style  face="normal" font="default" size="100%">Storage</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">901-906</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of the present study was to validate HPLC method for analysis bromelain levels in pineapple water and application that method to determine the storage time of pineapple water. &lt;strong&gt;Methods:&lt;/strong&gt; The reversed phase of HPLC method was tested and optimized before it is validated. The composition and the flow rate of the mobile phase is the optimized parameter. The analytical parameters validated were detection limits, linearity, accuracy and precision. Pineapple water was stored for 8 h at 10ºC and bromelain was determined using the validated HPLC method.&lt;strong&gt; Result: &lt;/strong&gt;The optimum mobile phase composition was methanolwater (70:30) with a flow rate of 1 ml/min. The detector concentration-response was linear with coefficient of determination of 0.993. The accuracy of HPLC method at a recovery of 1 and 2% bromelain was 106.37 ± 1.94% and 98.12 ± 1.29% (n = 5), respectively. The precision, expressed as the coefficients of variation (CV), at 1 and 2% bromelain were 1.83 and 1.32% (n = 5), respectively. Bromelain level at zero time was 81.53%. After storage for 8 h at 10ºC, bromelain levels in pineapple juice appeared to decrease not statistically significant (p &amp;gt; 0.05), with to mean value of 78.46 ± 2.88%. &lt;strong&gt;Conclusion:&lt;/strong&gt; The HPLC method developed was valid to analyze accurately concentrations of bromelain in pineapple water and it can be used to study the shelf life of pineapple water based on bromelain content. The bromelain content in pineapple juice was not statistically significantly different after 8 h storage at 10°C.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">901</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Novi Yantih&lt;sup&gt;1,&lt;/sup&gt;*, Alfadella Methananda&lt;sup&gt;1&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;2&lt;/sup&gt;, Wahono Sumaryono&lt;sup&gt;1&lt;/sup&gt;, Lestari Rahayu&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Pancasila, South Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author><author><style face="normal" font="default" size="100%">Subehan Lallo</style></author><author><style face="normal" font="default" size="100%">Masteria Yunovilsa Putra</style></author><author><style face="normal" font="default" size="100%">Tri Aryono Hadi</style></author><author><style face="normal" font="default" size="100%">Ibrahim Jantan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial and Cytotoxic Activities of Sponges Collected off the Coast of Togean Islands, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT</style></keyword><keyword><style  face="normal" font="default" size="100%">Sponges</style></keyword><keyword><style  face="normal" font="default" size="100%">Togean Islands</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">988-992</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Marine sponges (Porifera: Demospongia) have astonishing structural diversity and broad biological activities.&lt;strong&gt; Aims:&lt;/strong&gt; To evaluate the antibacterial and cytotoxic activities of five sponges collected off the coast of Togean Islands, Indonesia, identified as &lt;em&gt;Spheciospongia inconstan, Melophlus sarasironum, Oceanapia amboinensis, Biemna&lt;/em&gt; sp and &lt;em&gt;Axinella&lt;/em&gt; sp. &lt;strong&gt;Methods and Material:&lt;/strong&gt; All dried sponges materials were extracted by maceration method using methanol and then evaporated by the rotary evaporator to obtain viscous extracts. The determination of antibacterial activity was performed by well agar diffusion method against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Escherichia coli&lt;/em&gt; while the cytotoxic activity was determined by MTT methods on human breast adenocarcinoma (MCF-7) and human colon colorectal carcinoma (HCT-116), followed by determination of the apoptosis mechanism by Annexin V-FTIC assay. &lt;strong&gt;Results:&lt;/strong&gt;&lt;em&gt; M. sarasinorum and Axinella&lt;/em&gt; sp showed strong inhibition against S.aureus and E.coli with the diameter of inhibition of 14.21 &amp;plusmn; 0.92 mm and 14.36 &amp;plusmn; 0.92 mm, and 10.01 &amp;plusmn; 2.65 mm and 12.07 &amp;plusmn; 1.54 mm, respectively. Moreover, they also exhibited potent cytotoxicity on HCT-116 with IC&lt;sub&gt;50&lt;/sub&gt; values of 0.002 and 8.518 &amp;mu;g/mL, respectively. Meanwhile, on MCF-7, only M. sarasinorum showed moderate inhibition with an IC&lt;sub&gt;50&lt;/sub&gt; value of 87.35 &amp;mu;g/mL. Annexin V-FTIC assay clearly showed that the cytotoxic mechanism of &lt;em&gt;M. sarasinorum and Axinella&lt;/em&gt; sp on HCT-116 and MCF-7 was via apoptosis induction. &lt;strong&gt;Conclusion:&lt;/strong&gt; The sponges of &lt;em&gt;M. Sarasinorum and Axinella&lt;/em&gt; sp are undergoing further analysis to identify the active constituents which could be developed as potential antibacterial and anticancer agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">988</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Muhammad Sulaiman Zubair&lt;sup&gt;1*&lt;/sup&gt;, Subehan Lallo&lt;sup&gt;2&lt;/sup&gt;, Masteria Yunovilsa Putra&lt;sup&gt;3&lt;/sup&gt;, Tri Aryono Hadi&lt;sup&gt;3&lt;/sup&gt;, Ibrahim Jantan&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Sciences, Tadulako University, Kampus Bumi Tadulako, Palu, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Centre for Oceanography, Indonesian Institute of Sciences, Jl. Pasir Putih I, Ancol Timur, Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug and Herbal Research Center, Faculty of Pharmacy, National University of Malaysia, Kuala Lumpur, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oukacha Amri</style></author><author><style face="normal" font="default" size="100%">Abderrahmane Zekhnini</style></author><author><style face="normal" font="default" size="100%">Abdellah Bouhaimi</style></author><author><style face="normal" font="default" size="100%">Saida Tahrouch</style></author><author><style face="normal" font="default" size="100%">Abdelhakim Hatimi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity of Methanolic Extract from Pistacia atlantica Desf. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanolic extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Plantar edema</style></keyword><keyword><style  face="normal" font="default" size="100%">TLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/369</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">71-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The extracts of the &lt;em&gt;Pistacia&lt;/em&gt; species are known for their anti-inflammatory activity, including fruits and oil of &lt;em&gt;P.&amp;nbsp;atlantica.&lt;/em&gt; However, the inflammatory effect of the methanolic extract of &lt;em&gt;P.&amp;nbsp;atlantica&lt;/em&gt; leaves has not been studied. This work aimed at assessing the antiinflammatory and antioxidant activities of &lt;em&gt;P.&amp;nbsp;atlantica&lt;/em&gt; leaves extract in relation to phytochemical studies of flavonoids. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was obtained using sonication of leaves powder in 80 % methanol. The analysis of phenolic compounds was carried out using thin-layer chromatography (TLC). The antioxidant activity was evaluated using DPPH, ABTS and FRAP assays. The anti-inflammatory activity was determined by the reduction of carrageenaninduced hind paw edema in mice. &lt;strong&gt;Results:&lt;/strong&gt; The TLC revealed 3 glycosylated flavonoids and gallic acid derivatives. The flavonoids identified corresponded to rutin, quercetrin and other heterosides of quercetin, kaempferol and myricetin. Total phenolics and flavonoids contents were comparable for the male and female trees. The antioxidant activity did not show a significative difference between the two sexes, except for that evaluated by the FRAP assay which was significantly greater for the male tree leaves extract. The leaves extract permitted significative reduction of the edema at h3 and 6 in a dose-dependent manner (100 and 250 mg/kg), while diclofenac used as control reduced the edema at h 1.5. This difference could be explained by the pharmacokinetic and pharmacodynamic properties of diclofenac and &lt;em&gt;P. atlantica &lt;/em&gt;leaves compounds. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;P. atlantica&lt;/em&gt; has a strong anti-inflammatory activity and constitutes a potential source for the development of new treatments.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Oukacha Amri&lt;sup&gt;1&lt;/sup&gt;, Abderrahmane Zekhnini&lt;sup&gt;2&lt;/sup&gt;*, Abdellah Bouhaimi&lt;sup&gt;2&lt;/sup&gt;, Saida Tahrouch&lt;sup&gt;1&lt;/sup&gt;, Abdelhakim Hatimi&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratoire de Biotechnologies V&amp;eacute;g&amp;eacute;tales, Facult&amp;eacute; des Sciences, 80 000 Agadir, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratoire des Syst&amp;egrave;mes Aquatiques, Facult&amp;eacute; des Sciences, 80 000 Agadir, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raghavendra H.L</style></author><author><style face="normal" font="default" size="100%">Prashith Kekuda T.R</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiradical and Lipid Peroxidation Inhibitory Activity of Ripe and Unripe Fruit of Rubus steudneri Schweinf. (Rosaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Free radical</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Maceration</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Rubus steudneri Schweinf</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/677</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">818-822</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; A free radical is a molecular species characterized by the presence of an unpaired electron in its outer orbital. Free radicals are highly reactive and are known to damage biomolecules including lipids resulting in a myriad of pathophysiological conditions. The present investigation was carried out to screen antiradical and lipid peroxidation inhibitory activity of ripe and unripe fruit of R. steudneri. &lt;strong&gt;Methods:&lt;/strong&gt; The powdered ripe and unripe fruit materials were extracted by maceration process using methanol. Antiradical activity of extracts was evaluated by DPPH and hydroxyl radical scavenging assays. Lipid peroxidation inhibition assay was carried out by estimating the thiobarbituric acid reactive substances. Both ripe and unripe fruit extracts were screened for the presence of phytochemicals viz. alkaloids, flavonoids, tannins, phenolic compounds, saponins, glycosides, sterols and triterpenoids by standard tests. &lt;strong&gt;Results:&lt;/strong&gt; Preliminary phytochemical analysis indicated that both ripe and unripe fruit extracts contain saponins, alkaloids, phenolic compounds, flavonoids, tannins, sterols and triterpenoids. When compared to unripe fruit extract, ripe fruit extract displayed marked scavenging of DPPH and hydroxyl radicals and inhibition of lipid peroxidation as indicated by lower IC&lt;sub&gt;50&lt;/sub&gt; values. &lt;strong&gt;Conclusion:&lt;/strong&gt; Overall, ripe fruit extract displayed marked free radical scavenging and lipid peroxidation inhibitory activity. The presence of phenolic and flavonoid compounds in the extracts might be responsible for observed bioactivities of ripe and unripe fruit of &lt;em&gt;R. steudneri&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Short Communication</style></work-type><section><style face="normal" font="default" size="100%">818</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Raghavendra H.L&lt;sup&gt;1*&lt;/sup&gt;, Prashith Kekuda T.R&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;2&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, School of Medicine, Wollega University, Nekemte, Ethiopia, EAST AFRICA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, S.R.N.M.N College of Applied Sciences, N.E.S Campus, Balraj Urs Road, Shivamogga, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Yesi Desmiaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Arginase Inhibitory, Antioxidant Activity and Pharmacognosy Study of Sterculia macrophylla Vent. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Arginase</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostical</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia macrophylla</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1109-1113</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The purpose of this study was to investigate the arginase inhibitory activity, antioxidant activity, and also pharmacognostical study of &lt;em&gt;Sterculia macrophylla&lt;/em&gt; leaves. The main component of genus &lt;em&gt;Sterculia&lt;/em&gt; was flavonoid that was well known to demonstrate arginase inhibitory activity. &lt;strong&gt;Methods:&lt;/strong&gt; Sample was extracted gradually using n-hexane, ethyl acetate, and methanol solvents, subsequently. The n-hexane, ethyl acetate, and methanol extract were determined for their arginase inhibitory activity. The most active extract was methanol extract. This extract was determined for its antioxidant activity, arginase inhibitory activity, identification of chemical compound, chromatogram profile and determined the content of total flavonoid. The leaves and powder of &lt;em&gt;Sterculia macrophylla&lt;/em&gt; were identified with microscopic and macroscopic evaluation. &lt;strong&gt;Results:&lt;/strong&gt; The most active extract was methanol extract with IC&lt;sub&gt;50&lt;/sub&gt; 114,659 &amp;mu;g/mL for arginase inhibitory activity and IC&lt;sub&gt;50&lt;/sub&gt; 78.47 &amp;mu;g/mL for DPPH scavenging activity. The secondary metabolite of methanol extract presence compound of alkaloid, flavonoid, tannin, terpene, and glycoside. The total flavonoid content was 141.10 mg/gram extract. The star-shape trichoma was identified as a specific fragment. &lt;strong&gt;Conclusion:&lt;/strong&gt; The methanol extract of &lt;em&gt;Sterculia macrophylla&lt;/em&gt; showed activity as arginase inhibitor and antioxidant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1109</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Rani Sauriasari&lt;sup&gt;3&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;4&lt;/sup&gt;, Yesi Desmiaty&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy Universities Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof. Dr. Hamka University, 1340 Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Indonesia University, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Science, Serpong (LIPI) INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy Universitas Pancasila, Depok, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sylvia Utami Tunjung Pratiwi</style></author><author><style face="normal" font="default" size="100%">Titik Tri Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Attenuation of Pseudomonas aeruginosa Virulence by Some Indonesian Medicinal Plants Ethanolic Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-pathogenic drugs</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Quorum quenching</style></keyword><keyword><style  face="normal" font="default" size="100%">Quorum sensing inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">983-987</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; One strategy to address the emergence of infectious diseases supported by the increasing cases of microbial antibiotic resistance is the development of anti-pathogenic drugs, a quorum quenching compound(s) capable of inhibiting microbial communication (quorum sensing inhibitor). &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; is one of the most common source of chronic opportunistic infections, which demonstrates the most consistent resistance to antimicrobial agents. Quorum sensing (QS) controls secretion of virulence factors in &lt;em&gt;P. aeruginosa&lt;/em&gt;.&lt;strong&gt; Aim:&lt;/strong&gt; This study aims to discover quorum sensing inhibitors (QSI) from some Indonesian medicinal plants ethanol extract to analyze their inhibitory activities against QS-mediated virulence factors in&lt;em&gt; P. aeruginosa&lt;/em&gt;. &lt;strong&gt;Settings and Design:&lt;/strong&gt; &lt;em&gt;In-vitro&lt;/em&gt; experimental study-laboratory setting &lt;strong&gt;Material and Methods:&lt;/strong&gt; Indonesian medicinal plant ethanolic extracts were tested for their capability to inhibit &lt;em&gt;P. aeruginosa&lt;/em&gt; motility, biofilm formation using microtiter plate method, pyocyanin and LasA production using LasA staphylolytic assay. Statistical analysis used: Statistical significance of the data were determined using one way ANOVA, followed by Dunnett&amp;rsquo;s test. Differences were considered significant with P values of 0.05 or less. &lt;strong&gt;Results:&lt;/strong&gt; Ethanolic extract of &lt;em&gt;T. catappa&lt;/em&gt; leaves and &lt;em&gt;A. alitilis&lt;/em&gt; flower capable to inhibit &lt;em&gt;P. aeruginosa&lt;/em&gt; motility as well as pyocyanin production and biofilm formation. Both extracts also showed capability in reducing LasA protease production. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;T. catappa&lt;/em&gt; and &lt;em&gt;A. alitilis&lt;/em&gt; are an interesting sources of innovative plant derived quorum quenching compound(s), thus can be used in the development of new antipathogenic drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">983</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sylvia Utami Tunjung Pratiwi&lt;sup&gt;1,2*&lt;/sup&gt;, Titik Tri Handayani&lt;sup&gt;1,2&amp;nbsp;&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Centre for Natural Anti-infective Research (CNAIR), Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">NMU</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/359</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to evaluate the possible protective effect of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 &amp;mu;g/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 and &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the anti-inflammatory, antioxidant, and anticancer properties of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;2&lt;/sup&gt;*, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;3&lt;/sup&gt;, C&amp;eacute;sar Franco-Quino&lt;sup&gt;3&lt;/sup&gt;, Ren&amp;aacute;n Ha&amp;ntilde;ari-Quispe&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima. PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga de Ica, Ica, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Physiology and Pharmacology, Faculty of Dentistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Animal Physiology, Universidad &amp;Aacute;ndina N&amp;eacute;stor C&amp;aacute;ceres Vel&amp;aacute;squez, Puno, PERU.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meri Susanti</style></author><author><style face="normal" font="default" size="100%">Sanusi Ibrahim</style></author><author><style face="normal" font="default" size="100%">Yahdiana Harahap</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison between High Performance Thin Layer Chromatography and High Performance Liquid Chromatography Methods for Determination of Rubraxanthone in the Stem Bark Extract of Garcinia cowa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">High Performance Liquid Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">High performance Thin layer Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">rubraxanthone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s42-s47</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To develop simple, rapid, accurate methods for determination of rubraxanthone in the stem bark extract of &lt;em&gt;Garcinia cowa&lt;/em&gt; using High Performance Thin Layer Chromatography (HPTLC) and High Performance Liquid Chromatography (HPLC). &lt;strong&gt;Methods:&lt;/strong&gt; The HPTLC method was performed on aluminum plate precoated with silica gel 60 F254 using Chloroform: Ethyl acetate: Methanol: Formic acid (88:2:2:8) as a developing system. Quantification was achieved using densitometric measurements at 243 nm. The HPLC method involved a 5 &amp;mu;m C18 column and an isocratic solvent using 0.4% formic acid: methanol (12:88) with a flow rate 1 mL minute-&lt;sup&gt;1&lt;/sup&gt;. Quantitation was also achieved with ultraviolet detection at 243 nm based on peak area. All necessary validation tests for both methods were done for their comparison. The results obtained by these two different quantification methods were compared by Tukey&amp;rsquo;s-test. &lt;strong&gt;Results:&lt;/strong&gt; Both assays provided good linearity, accuracy, precision, specificity and limits of detection and quantitation for determination of rubraxanthone in The Stem Bark extract of &lt;em&gt;G. cowa.&lt;/em&gt; &lt;strong&gt;Conclusion:&lt;/strong&gt; Both methods revealed reasonable validation parameters concerning linearity, accuracy, precision, specificity and limits of detection and quantitation. A statistical comparison of the quantitative analysis of rubraxanthone in extract did not show any statistically significant difference between two analysis methods. As both methods were found to be equal, they therefore can be used for the analysis of rubraxanthone in the Stem Bark extract of &lt;em&gt;G. cowa&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s42</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Meri Susanti&lt;sup&gt;1&lt;/sup&gt;, Sanusi Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Yahdiana Harahap&lt;sup&gt;3&lt;/sup&gt;, Dachriyanus&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University, West Sumatra, 25163, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, 16424, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramdan Btissam</style></author><author><style face="normal" font="default" size="100%">El Malki Fatima</style></author><author><style face="normal" font="default" size="100%">Eddarraji Kamal</style></author><author><style face="normal" font="default" size="100%">Greche Hassane</style></author><author><style face="normal" font="default" size="100%">NHIRI Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Composition and Antibacterial Activity of Hydro-Alcohol and Aqueous Extracts Obtained from the Lamiaceae Family</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous Extract.</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoic Content</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydro-Alcohol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Lamiaceae Family</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/402</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">81-91</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Plant from the &lt;em&gt;Lamiaceae&lt;/em&gt; family are considered as dietary spices and medicinal herbs traditionally used in medicine for the treatment of several pathologies. &lt;strong&gt;Objective:&lt;/strong&gt; Evaluation of the &lt;em&gt;in vitro&lt;/em&gt; antibacterial activity of ethanol and aqueous extracts of nine Moroccan plants from the Lamiaceae family against six bacterial strains regularly implicated in toxiinfection. &lt;strong&gt;Method:&lt;/strong&gt; The antibacterial activities of hot (HAE), cold (CAE) aqueous extracts and ethanolic extracts (EE) were evaluated using agar-well diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and IC&lt;sub&gt;50&lt;/sub&gt; against six foodborne bacteria (&lt;em&gt;Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa&lt;/em&gt; and &lt;em&gt;Salmonella enterica&lt;/em&gt;). Total phenolic and flavonoid contents were assessed as well. &lt;strong&gt;Results:&lt;/strong&gt; In the present study, the ethanol extracts were rich in polyphenols, with middling values of flavonoids, and relatively poor in condensed tannins. The presence of saponins, essential oils, irroides, alkaloids, anthocyanins, and aldehydes was recorded. The effect of the extracts was directly bactericidal for &lt;em&gt;B. cereus&lt;/em&gt; and &lt;em&gt;L. monocytogenes&lt;/em&gt;; for the other strains, the MBC value was twice higher than that of MIC. However, the ethanol extract (EE) of &lt;em&gt;O. majorana&lt;/em&gt; and &lt;em&gt;T. satureioides &lt;/em&gt;showed the highest antibacterial activity. With the principal component analysis, it was demonstrated that the nine &lt;em&gt;Lamiaceae&lt;/em&gt; family plants possess a powerful antibacterial effect, correlated with their phenolic content. &lt;strong&gt;Statistical analysis:&lt;/strong&gt; Analysis of variance was performed by uni-varied ANOVA in the software SPSS 22 Fr. &lt;strong&gt;Conclusion:&lt;/strong&gt; The active compounds were thermostable and soluble in ethanol and water. The antimicrobial activities of the plants extracts investigated may contribute to understand their involvement in traditional medicine against many microbial infections.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">81</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ramdan Btissam&lt;sup&gt;1&lt;/sup&gt;, El Malki Fatima&lt;sup&gt;2&lt;/sup&gt;, Eddarraji Kamal&lt;sup&gt;1,2&lt;/sup&gt;, Greche Hassane&lt;sup&gt;3&lt;/sup&gt; and Nhiri Mohamed&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Biology, Laboratory of Biochemistry and Molecular Genetics, Faculty of Science and Technology, University Abdelmalek Essaadi, BP 416, Tangier 90000, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Microbiology, Department of Hygiene and Food Safety, Pasteur Institute of Morocco, Tangier 90000, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;National Institute of Medicinal and Aromatic Plants, University of Sidi Mohamed Ben Abdellah, BP 8857, 30100 Atlas, Fes, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt;, Ethanol, Methanol, U87 cell line, Antiproliferative.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohd Adzim Khalili Rohin</style></author><author><style face="normal" font="default" size="100%">Mimie Noratiqah Jumli</style></author><author><style face="normal" font="default" size="100%">Norhaslinda Ridzwan</style></author><author><style face="normal" font="default" size="100%">Atif Amin Baig</style></author><author><style face="normal" font="default" size="100%">Ahmad Zubaidi Abdul Latif</style></author><author><style face="normal" font="default" size="100%">Norhayati Abd Hadi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Gynura procumbens Extracts on Anti-Proliferative Activity and its Associated Morphological Changes of Human Glioblastoma multiforme Cell Line (U-87)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiproliferative</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Gynura procumbens</style></keyword><keyword><style  face="normal" font="default" size="100%">Methanol</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/514</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">492-496</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Gynura procumbens&lt;/em&gt; (Lour.) Merr is a well-known traditional herb and is widely used for traditional medicine by human. Previous clinical studies have shown the benefit effect of this leaves with inflammation, high blood pressure and others. This study aims to investigate the effect of methanol, ethanol, and ethyl acetate extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; on U-87 cell line, human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cell line. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, effect of methanol, ethanol and ethyl acetate extracts on U-87 cell line was determined by MTT-based anti-proliferative assay and any significant changes to the cells towards apoptotic changes was observed under a light microscope. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; was found to have high anti-proliferative effect on U-87 cell line with IC&lt;sub&gt;50&lt;/sub&gt; less than 20&amp;mu;g/ml. By comparing IC&lt;sub&gt;50&lt;/sub&gt; value, ethanol and methanol extracts of &lt;em&gt;Gynura procumbens&lt;/em&gt; had high potential for anti-proliferative effect on U- 87 cell line. Therefore, ethanol and methanol extracts can be a potential anti-proliferative effect on U-87 cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; To the best of our knowledge, this is the first study of exploring the effect of &lt;em&gt;Gynura procumbens&lt;/em&gt; extracts using three different polarity (methanol, ethanol, ethyl acetate) effect on U-87 cell line, Human &lt;em&gt;Glioblastoma multiforme&lt;/em&gt; cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">492</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohd Adzim Khalili Rohin&lt;sup&gt;1,3,4&lt;/sup&gt;, Mimie Noratiqah Jumli&lt;sup&gt;1&lt;/sup&gt;, Norhaslinda Ridzwan&lt;sup&gt;1&lt;/sup&gt;, Atif Amin Baig&lt;sup&gt;2&lt;/sup&gt;, Ahmad Zubaidi Abdul Latif&lt;sup&gt;2&lt;/sup&gt;, Norhayati Abd Hadi&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Nutrition and Dietetic, Faculty of Health Sciences, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), Medical Campus, 20400 Kuala Terengganu, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centre for Continuing Education (CCE), Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute for Community (Health) Development, Universiti Sultan Zainal Abidin (UniSZA), Gong Badak Campus, 21300 Kuala Nerus, Terengganu, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marni Karo</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">WaOde Salma</style></author><author><style face="normal" font="default" size="100%">Ilhamjaya Patellongi</style></author><author><style face="normal" font="default" size="100%">Rosdiana Natzir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Miana (Coleus scutellariodes (L) Benth) to Expression of mRNA IL-37 in Balb/c Mice Infected Candida albicans</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CFU</style></keyword><keyword><style  face="normal" font="default" size="100%">Interleukin-37 mRNA</style></keyword><keyword><style  face="normal" font="default" size="100%">Miana</style></keyword><keyword><style  face="normal" font="default" size="100%">Realtime PCR</style></keyword><keyword><style  face="normal" font="default" size="100%">Vulvovaginal Candidiasis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/358</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">16-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Miana (&lt;em&gt;Coleus scutellariodes&lt;/em&gt; (L) Benth) are a herbal medicine with potential anti-inflammatory properties in patients infected with vulvovaginal candidiasis. The objective of this work was to the analyze IL-37 expression following administration of miana leaf extract (MLE) in an animal model of vulvovaginal candidiasis. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Adult Balb/c mice, aged 8&amp;ndash;12 weeks and weighing 30&amp;ndash;40 g, were divided into five groups. Four groups were administered &lt;em&gt;Candida albicans&lt;/em&gt; via intravaginal inoculation with a diluted dose of 10&lt;sup&gt;-2&lt;/sup&gt;/ ml and were treated with either MLE, a placebo, or ketoconazole; one group constituted the healthy control and was only treated with MLE. Real-time PCR was used to measure the expression of IL-37. &lt;strong&gt;Results:&lt;/strong&gt; These findings indicated that a component within MLE may mediate its anti-inflammatory characteristics, as indicated by the increase in mRNA IL-37 expression in mice inoculated with &lt;em&gt;C. albicans&lt;/em&gt;. The highest increase in fungal load to 101.6 CFU was observed in the placebo group at day 14. Whereas for the mice treated with MLE at 750 mg/kg b.w, the fungal load only increased to 30.0 CFU, similar to that of mice treated with ketoconazole (29.6 CFU). In the mice treated with MLE at 500 mg/kg b.w, the fungal load increased to 68.2 CFU. &lt;strong&gt;Conclusion:&lt;/strong&gt;&amp;nbsp;Fungiostatic effect of MLE 750 mg/kg BB is not less than ketoconazole and MLE may act as anti-inflammatory throught its role as an antioxidant so it could potentially be used as an alternative treatment in humans especially patients with vulvovaginal candidiasis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">16</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Marni Karo&lt;sup&gt;1&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;*, WaOde Salma&lt;sup&gt;3&lt;/sup&gt;, Ilhamjaya Patellongi&lt;sup&gt;4&lt;/sup&gt;, Rosdiana Natzir&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Midwifey Program of Medistra Health Higher School, Jakarta. Indonesia andSchool of Post Graduate Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Biology and Immunology Laboratory for Infection Diseases, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 3&lt;/sup&gt;Department Nutrition, Faculty of Medicine, Halu Oleo University, Kendari, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistic, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Senouci Bereksi</style></author><author><style face="normal" font="default" size="100%">Hafida Hassaïne</style></author><author><style face="normal" font="default" size="100%">Chahrazed Bekhechi</style></author><author><style face="normal" font="default" size="100%">Djamel Eddine Abdelouahid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of some Medicinal Plants Extracts Commonly Used in Algerian Traditional Medicine against some Pathogenic Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacterial resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydromethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition zones</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">MICs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/516</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">507-512</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to evaluate the antibacterial activity of hydromethanolic extracts of &lt;em&gt;Berberis vulgaris&lt;/em&gt;, &lt;em&gt;Cassia angustifolia&lt;/em&gt;, &lt;em&gt;Cinnamomum cassia, Cistus monspeliensis, Nigella sativa, Punica granatum, Rhus tripartata, Withania frutescens and Zingiber officinale&lt;/em&gt; against different Gram-positive and Gram-negative reference bacterial strains. &lt;strong&gt;Methods:&lt;/strong&gt; The evaluation of antibacterial activity for different extracts of each plant was carried out using the disc diffusion method and determination of minimum inhibitory concentration (MIC). &lt;strong&gt;Results:&lt;/strong&gt; The plant extracts showed zone of inhibition ranging from 06.0 to 23.0 mm against one or more tested bacteria, and their efficacy in terms of MICs where ranged from 0.1 to 12.8 mg/mL. The Refluxed and Macerated extracts of these plants have shown relatively similar results in terms of diameters of inhibition and MICs. The extracts of &lt;em&gt;B. vulgaris, C. monspeliensis and P. granatum&lt;/em&gt; demonstrated relatively high activity as compared to the other plant extracts mainly against &lt;em&gt;S. aureus, E. faecalis and E. cloacae&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study indicate that hydromethanolic extracts of these plants have antibacterial activity against the different tested bacterial strains. This activity supports their use in treatment of infections caused by such resistant bacteria.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">507</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohamed Senouci Bereksi&lt;sup&gt;1*&lt;/sup&gt;, Hafida Hassa&amp;iuml;ne&lt;sup&gt;2&lt;/sup&gt;, Chahrazed Bekhechi&lt;sup&gt;1&lt;/sup&gt;, Djamel Eddine Abdelouahid&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Natural Products, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Applied Microbiology in Food, Biomedical and Environment, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamed Senouci Bereksi</style></author><author><style face="normal" font="default" size="100%">Hafida Hassaïne</style></author><author><style face="normal" font="default" size="100%">Chahrazed Bekhechi</style></author><author><style face="normal" font="default" size="100%">Djamel Eddine Abdelouahid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial Activity of Some Medicinal Plants Extracts Commonly Used in Algerian Traditional Medicine against Some Pathogenic Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bacterial resistance.</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydromethanolic extracts</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition zones</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">MICs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">x</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">XX-XX</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The objective of this study was to evaluate the antibacterial activity of hydromethanolic extracts of &lt;em&gt;Berberis vulgaris, Cassia angustifolia, Cinnamomum cassia, Cistus monspeliensis, Nigella sativa, Punica granatum, Rhus tripartata, Withania frutescens and Zingiber officinale&lt;/em&gt; against different Gram-positive and Gram-negative reference bacterial strains. &lt;strong&gt;Methods:&lt;/strong&gt; The evaluation of antibacterial activity for different extracts of each plant was carried out using the disc diffusion method and determination of minimum inhibitory concentration (MIC). &lt;strong&gt;Results:&lt;/strong&gt; The plant extracts showed zone of inhibition ranging from 06.0 to 23.0 mm against one or more tested bacteria, and their efficacy in terms of MICs where ranged from 0.1 to 12.8 mg/mL. The Refluxed and Macerated extracts of these plants have shown relatively similar results in terms of diameters of inhibition and MICs. The extracts of &lt;em&gt;B. vulgaris, C. monspeliensis and P. granatum&lt;/em&gt; demonstrated relatively high activity as compared to the other plant extracts mainly against &lt;em&gt;S. aureus, E. faecalis and E. cloacae&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; Findings of this study indicate that hydromethanolic extracts of these plants have antibacterial activity against the different tested bacterial strains. This activity supports their use in treatment of infections caused by such resistant bacteria.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Medicinal plants, Hydromethanolic extracts, Antibacterial activity, Inhibition zones, MICs, Bacterial resistance.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2s</style></issue><work-type><style face="normal" font="default" size="100%">x</style></work-type><section><style face="normal" font="default" size="100%">XX</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohamed Senouci Bereksi&lt;sup&gt;1*&lt;/sup&gt;, Hafida Hassa&amp;iuml;ne&lt;sup&gt;2&lt;/sup&gt;, Chahrazed Bekhechi&lt;sup&gt;1&lt;/sup&gt;, Djamel Eddine Abdelouahid&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Natural Products, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA. &lt;sup&gt;2&lt;/sup&gt;Laboratory of Applied Microbiology in Food, Biomedical and Environment, Department of Biology, University of Tlemcen, 13000 Tlemcen, ALGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Parichat Phalanisong</style></author><author><style face="normal" font="default" size="100%">Kanit Vichitphan</style></author><author><style face="normal" font="default" size="100%">Jaehong Han</style></author><author><style face="normal" font="default" size="100%">Sukanda Vichitphan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">High Antioxidant and Phenolic Contents Related to Antibacterial Activity against Gastrointestinal Pathogenic Bacteria of Some Thai Medicinal Plants</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscope</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/488</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">341-348</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Thai medicinal plants were used as the traditional medicines and as part of everyday plants diet. Plants contain a mixture of phytochemical and exhibit a lot of functional food and medicinal properties. This project aims to investigate the potential of selected Thai medicinal plants according to the properties of their antioxidant and antibacterial activities. &lt;strong&gt;Methods:&lt;/strong&gt; The eighteen plants were extracted using maceration method with 95% ethanol. The antioxidant activity was evaluated by DPPH and FRAP assay. The total phenolic content was evaluated by Folin-Ciocalteu phenol reagent. The antibacterial activity was evaluated by agar disc diffusion method. The extract which exhibited high antioxidant and antibacterial activity was selected to observe morphological changes by the scanning electron microscope (SEM). &lt;strong&gt;Results:&lt;/strong&gt; The extract of &lt;em&gt;Caesalpinia sappan&lt;/em&gt; showed the highest activities on both antioxidant assayed by FRAP method and total phenolic contents, however, exhibited high antioxidant assayed by DPPH compared to &lt;em&gt;Bauhinia strychnifolia&lt;/em&gt; extract. Moreover, the extract of &lt;em&gt;C. sappan&lt;/em&gt; showed the excellent antibacterial activities against six pathogenic bacteria in Gastro-intestinal tract. The morphological change by SEM was selected for further investigation antibacterial activities of &lt;em&gt;C. sappan&lt;/em&gt; extract. The results showed that the inhibitory effect to those bacterial strains could be caused by the disruption of the cell membrane and decrease biofilm formation after treatment with the extract. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of &lt;em&gt;C. sappan&lt;/em&gt; exhibited strong antioxidant and antibacterial activities against the six pathogenic bacteria. This result suggested that &lt;em&gt;C. sappan&lt;/em&gt; could be applied to use for medicinal purpose and functional products.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">341</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Parichat Phalanisong&lt;sup&gt;1,2,&lt;/sup&gt; Kanit Vichitphan&lt;sup&gt;2,3&lt;/sup&gt;*, Jaehong Han&lt;sup&gt;4&lt;/sup&gt;, Sukanda Vichitphan&lt;sup&gt;2,3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Graduate School, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Faculty of Technology, Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Fermentation Research Center for Value Added Agricultural Products (FerVAAP), Khon Kaen University, Khon Kaen, THAILAND.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Integrative Plant Science, Chung-Ang University, Anseong, KOREA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sandhya Panicker</style></author><author><style face="normal" font="default" size="100%">Veluthat Kolangara Haridasan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity Study on U87 Cells Using Root Extracts of Plumbago Species and GC-MS Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactive constituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">U87 cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s71-s76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Plumbago is a genus of medicinal plants that are used in recent years to induce significant levels of apoptosis in various cancer cells. Purpose: The test substances that are obtained from Plumbago species are studied for their cytotoxicity against U87 cell line in a dose dependent manner and were first subjected to GC-MS study to know the bioactive constituents present in them. Methods: GC-MS was done using ethanol extracts of the roots of both the species. In vitro cytotoxicity of the roots of two species of Plumbago &amp;ndash;&lt;em&gt;P. zeylanica&lt;/em&gt; (sample I) and &lt;em&gt;P.&amp;nbsp;auriculata&lt;/em&gt; (sample II) were tested against U87 cell line. Test samples were taken at concentrations ranging from 400&amp;mu;g/ml to 3.12&amp;mu;g/ml to determine the percentage growth inhibition of both the test substances on U87 cell line. Results: GC-MS analysis on root extracts of P.zeylanica showed the presence of 27 phytochemical constituents and P.auriculata 16 in number .The test substances, Sample I and Sample II exhibited a cytotoxic CTC50 value of 88.07&amp;plusmn;4.4 and 23.11&amp;plusmn;0.9 respectively. Conclusion: &lt;em&gt;P.&amp;nbsp;zeylanica &lt;/em&gt;is more effective than &lt;em&gt;P.&amp;nbsp;auriculata&lt;/em&gt; in terms of its cytotoxicity as well in the number of useful bioactive compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s71</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sandhya Panicker&lt;sup&gt;1,*&lt;/sup&gt;, Veluthat Kolangara Haridasan&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Research and Development centre, Bharathiar University, Coimbatore-641046, Tamil Nadu, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, Post Graduate and Research Centre, St Joseph&amp;rsquo;s College, Bangalore -560027, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Adrian Hutchings</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Interactive Antimicrobial Activity of Embelica officinalis Gaertn. Fruit Extracts and Conventional Antibiotics against Some Bacterial Triggers of Autoimmune Inflammatory Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amla</style></keyword><keyword><style  face="normal" font="default" size="100%">ankylosing spondylitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Combinational therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Indian gooseberry</style></keyword><keyword><style  face="normal" font="default" size="100%">Multi-drug resistant bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">multiple sclerosis</style></keyword><keyword><style  face="normal" font="default" size="100%">rheumatoid arthritis</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/646</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">654-662</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Embelica officinalis&lt;/em&gt; Gaertn. is an Indian plant which is known for its therapeutic properties. It is especially well known as a component of the Ayuverdic medicine Triphala. This study focuses on the growth inhibitory activity of &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts against some bacterial triggers of autoimmune inflammatory diseases, both alone and in combination with conventional antibiotics. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;E. officinalis&lt;/em&gt; fruit powder was extracted with solvents of varying polarity and screened for bacterial growth inhibition by disc diffusion assay. The minimum inhibitory concentration (MIC) was quantified by both liquid dilution and disc diffusion techniques. To screen for combinatorial effects, the &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts were combined with a range of conventional antibiotics and tested against each bacteria using a liquid dilution assay. Toxicity was examined using &lt;em&gt;Artemia&lt;/em&gt; nauplii and HDF bioassays. &lt;strong&gt;Results:&lt;/strong&gt; The ethyl acetate &lt;em&gt;E. officinalis&lt;/em&gt; fruit extract displayed the strongest growth inhibitory activity against all of the bacterial triggers of autoimmune inflammatory disease. This extract was a particularly potent inhibitor of P. aeruginosa growth, with an MIC values as low as 264 &amp;mu;g/mL. The ethyl acetate extract was also a moderate to strong growth inhibitor of &lt;em&gt;P. mirabilis&lt;/em&gt;, &lt;em&gt;K. pneumonia&lt;/em&gt; and &lt;em&gt;A. baylyi&lt;/em&gt;, with MIC values generally 1000-1500 &amp;mu;g/mL. The methanolic and aqueous extracts also inhibited the growth of all bacteria, although generally with only moderate to low activity. Whilst no synergistic interactions were detected in combinations containing the &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts and conventional antibiotics, a number of combinations produced additive effects. These combinations are beneficial as they provide enhanced antibacterial efficacy compared to treatment with the antibiotic or extract components alone. No antagonistic interactions were detected. Therefore, use of the extracts in combination with conventional antibiotics would not compromise the antibiotics efficacy. All extracts were nontoxic in the &lt;em&gt;Artemia&lt;/em&gt; nauplii and HDF toxicity assays, further indicating their potential for medicinal use. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;E. officinalis&lt;/em&gt; fruit extracts were moderate inhibitors of the bacterial triggers of selected autoimmune inflammatory diseases. Furthermore, the extracts potentiated the activity of chloramphenicol and tetracycline against otherwise resistant bacterial strains. Isolation of the active compounds and the potentiating agents may be beneficial in antibiotic drug design.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">654</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Adrian Hutchings&lt;sup&gt;1&lt;/sup&gt;, Ian Edwin Cock &lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1,2*&lt;/strong&gt; &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland, AUSTRALIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland, AUSTRALIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Heba Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Mortada Mohamed El-Sayed</style></author><author><style face="normal" font="default" size="100%">Afaf Ahmed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Maher Mahmoud Hashash</style></author><author><style face="normal" font="default" size="100%">Ahmed Mohamed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Tarek Aboushousha</style></author><author><style face="normal" font="default" size="100%">El-Sayed Saleh Abdel-Hameed</style></author><author><style face="normal" font="default" size="100%">Ezzat El-Sayed Abdel- Lateef</style></author><author><style face="normal" font="default" size="100%">Eman Abdalla Morsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Ascorbic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenyl etanoid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/410</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">136-147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: &lt;em&gt;Lantana camara&lt;/em&gt; and &lt;em&gt;Cucurbita pepo&lt;/em&gt; and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of &lt;em&gt;L. camara&lt;/em&gt; by HPLC-ESI- MS. &lt;strong&gt;Methods:&lt;/strong&gt; Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. &lt;strong&gt;Results:&lt;/strong&gt; The defatted methanolic extract and ethyl acetate fraction of &lt;em&gt;L. camara&lt;/em&gt; showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of &lt;em&gt;L. camara&lt;/em&gt; extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; The phytochemical constituents of &lt;em&gt;L. camara &lt;/em&gt;are responsible for their nephroprotective activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Heba Abdel-Hady&lt;sup&gt;1&lt;/sup&gt;*, Mortada Mohamed El-Sayed&lt;sup&gt;1&lt;/sup&gt; , Afaf Ahmed Abdel-Hady&lt;sup&gt;2&lt;/sup&gt;, Maher Mahmoud Hashash&lt;sup&gt;3&lt;/sup&gt;, Ahmed Mohamed Abdel-Hady&lt;sup&gt;4&lt;/sup&gt;, Tarek Aboushousha&lt;sup&gt;4&lt;/sup&gt;, El-Sayed Saleh Abdel-Hameed&lt;sup&gt;1&lt;/sup&gt;, Ezzat El-Sayed Abdel-Lateef&lt;sup&gt;1&lt;/sup&gt;, Eman Abdalla Morsi&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;ClinicalChemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science, Ain Shams University, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pathology Department, Theodor Bilharz Research Institute, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laura Aracely Contreras-Angulo</style></author><author><style face="normal" font="default" size="100%">Denisse Vega-Gaxiola</style></author><author><style face="normal" font="default" size="100%">Alexis Emus-Medina</style></author><author><style face="normal" font="default" size="100%">Jose Basilio Heredia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Leaves of Hedeoma patens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bioactives</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical/ Nutraceutical Industries</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oils</style></keyword><keyword><style  face="normal" font="default" size="100%">Hedeoma patens J</style></keyword><keyword><style  face="normal" font="default" size="100%">Oregano</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">921-924</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oregano is a plant consumed as a spice and used to a lesser extent as a medicinal plant for the treatment of respiratory and stomach diseases, among others. Oregano is made up of a large number of species and is currently under study for its antimicrobial, antioxidant, anti-inflammatory and hypoglycemic properties. However, pharmacognostic studies of some wild species are lacking. &lt;strong&gt;Methods:&lt;/strong&gt; The present research aims to identify taxonomically and to evaluate the morphological characteristics of &lt;em&gt;Hedeoma patens&lt;/em&gt;, a plant used as oregano in Mexico. &lt;strong&gt;Results:&lt;/strong&gt; The specimens were identified as &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and their main morphological features were trichome-pelted sites for synthesis of essential oils. &lt;strong&gt;Conclusion:&lt;/strong&gt; The plant used in Badiraguato, Sinaloa is &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and the structures that synthesize phenolic compounds and essential oils could suggest a potential use of this plant and will form a basis for future research.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">921</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Laura Aracely Contreras-Angulo, Denisse Vega-Gaxiola, Alexis Emus-Medina, Jose Basilio Heredia* &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Centro de Investigaci&amp;oacute;n en Alimentaci&amp;oacute;n y Desarrollo A.C., Carretera a Eldorado Km 5.5 Campo el Diez, Culiac&amp;aacute;n, Sinaloa, M&amp;Eacute;XICO. 80110.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laura Aracely Contreras-Angulo</style></author><author><style face="normal" font="default" size="100%">Denisse Vega-Gaxiola</style></author><author><style face="normal" font="default" size="100%">Alexis Emus-Medina</style></author><author><style face="normal" font="default" size="100%">Jose Basilio Heredia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Study of Leaves of Hedeoma patens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-76</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Oregano is a plant consumed as a spice and used to a lesser extent as a medicinal plant for the treatment of respiratory and stomach diseases, among others. Oregano is made up of a large number of species and is currently under study for its antimicrobial, antioxidant, anti-inflammatory and hypoglycemic properties. However, pharmacognostic studies of some wild species are lacking. &lt;strong&gt;Methods:&lt;/strong&gt; The present research aims to identify taxonomically and to evaluate the morphological characteristics of &lt;em&gt;Hedeoma patens&lt;/em&gt;, a plant used as oregano in Mexico. &lt;strong&gt;Results:&lt;/strong&gt; The specimens were identified as &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and their main morphological features were trichome-pelted sites for synthesis of essential oils. &lt;strong&gt;Conclusion:&lt;/strong&gt; The plant used in Badiraguato, Sinaloa is &lt;em&gt;Hedeoma patens&lt;/em&gt; J. and the structures that synthesize phenolic compounds and essential oils could suggest a potential use of this plant and will form a basis for future research.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt; Key words:&lt;/strong&gt; Essential oils, Bioactives, &lt;em&gt;Hedeoma patens&lt;/em&gt; J, Oregano, Pharmacognostic, Chemical/ Nutraceutical Industries.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Laura Aracely Contreras-Angulo, Denisse Vega-Gaxiola, Alexis Emus-Medina, Jose Basilio Heredia*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Centro de Investigaci&amp;oacute;n en Alimentaci&amp;oacute;n y Desarrollo A.C., Carretera a Eldorado Km 5.5 Campo el Diez, Culiac&amp;aacute;n, Sinaloa, M&amp;Eacute;XICO. 80110.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognosy, Phytochemical Study and Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia rubiginosa zoll. ex Miq</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/526</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">571-575</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Sterculia rubiginosa &lt;/em&gt;Zoll ex.Miq leaves have been used as traditional medicine in Indonesia. There is no report about pharmacognosy and phytochemical study with this plant.&lt;strong&gt;Objective:&lt;/strong&gt; The main aim of this research is to establish pharmacognosy, phytochemical study and antioxidant activity of &lt;em&gt;Sterculia rubiginosa&lt;/em&gt; Zoll.ex. Miq. Leaves. The plant used to cure many diseases of Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; In the present study, pharmacognosy and phytochemical study of plant material were performed as per the Indonesian Herb Pharmacopoeia. &lt;strong&gt;Results:&lt;/strong&gt; Microscopy powder of &lt;em&gt;Sterculia rubiginosa&lt;/em&gt; Zoll.ex. Miq. Leaves shows star shape trichoma as a specific fragment. Physicochemical parameters including total ash (17,152 %), acid-insoluble ash (0,922 %), water-soluble extractive (1,610 % w/w), alcohol-soluble extractive (4,524 % w/w), hexane-soluble extractive (4,005 % w/w), and ethyl acetate-soluble extractive (3,160 % w/w) were evaluated. Phytochemical screening of ethanol extracts showed the presence of tannins, flavonoids, alkaloids, steroids-terpenoids, glycosides, and phenols. And absent of saponins and Anthraquinones. Antioxidant activity with IC&lt;sub&gt;50&lt;/sub&gt; 157, 4665 ppm and flavonoid total was 59,436 mg/g quercetin equivalent. &lt;strong&gt;Conclusion:&lt;/strong&gt; The pharmacognosy, physiochemical, and phytochemical evaluation provides information for the safety, identification, and class of chemical constituent&amp;rsquo;s presents in this crude extract.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">571</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,2*&lt;/sup&gt;, Berna Elya&lt;sup&gt;2&lt;/sup&gt;, Rani Sauriasari&lt;sup&gt;3&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;4&lt;/sup&gt;, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy and Science Muhammadiyah Prof.Dr. Hamka University, 1340 Jakarta 16470, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy- Phytochemistry, Faculty of Pharmacy Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Indonesia University, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Centre for Chemistry Indonesian Institute of Science, Jakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Atun</style></author><author><style face="normal" font="default" size="100%">Sri Handayani</style></author><author><style face="normal" font="default" size="100%">Anna Rakhmawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potential Bioactive Compounds Isolated from Boesenbergia rotunda as Antioxidant and Antimicrobial Agents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Boesenbergia rotunda</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/517</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">513-518</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study was conducted to identify some bioactive compounds of &lt;em&gt;Boesenbergia rotunda rhizome&lt;/em&gt; and to test as antioxidant and antimicrobial agents. &lt;strong&gt;Methods:&lt;/strong&gt; The milled dried rhizome of &lt;em&gt;B. Rotunda&lt;/em&gt; (5kg) was extracted exhaustively with ethanol. The ethanol extract was partitioned three times by n-hexane, chloroform, and ethyl acetate respectively. Each fraction was fractionated by vacuum liquid chromatography (VLC) and then purified by column chromatography gravitation. Structural identification of all pure compounds were elucidated based on spectroscopic methods (UV, IR, and NMR).The antioxidant activity was tested by 2,2-diphenyl- 1-picrylhydrazyl (DPPH). Antimicrobial character was screened for activities againts pathogenic bacteria i.e. &lt;em&gt;Escherichia coli&lt;/em&gt; ATCC-11229, Staphylococcus aureus ATCC-25923, Staphylococcus epidermidis FNCC-0048, and Streptococcus mutans by the disk-diffusion method. The assay was done in triplicate, and chloramphenicol was used as the positive control. Results and &lt;strong&gt;Discussion:&lt;/strong&gt; From ethanol extract of &lt;em&gt;B. rotunda&lt;/em&gt; three known compounds of flavanones, namely 2&amp;rsquo;,4&amp;rsquo;-dihydroxy-6-methoxychalcone (compound-1), 5-hydroxy-7- methoxyflavanone (compound-2), and 5,7-dihydroxyflavanone (compound-3) were isolated. The ethanol extract of &lt;em&gt;B. rotunda&lt;/em&gt; and the three isolated compounds -1,-2, and -3 showed an antioxidant activity with the IC value of 92.64; 46.66; 62.84, and 62.66 &amp;mu;g/mL, respectively. The zone of inhibition of extract and the three isolated compounds showed moderate activity against &lt;em&gt;Escherichia coli&lt;/em&gt; ATCC-11229, &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC-25923, &lt;em&gt;Staphylococcus epidermidis&lt;/em&gt; FNCC-0048, and &lt;em&gt;Streptococcus mutans&lt;/em&gt;.The maximum zone of inhibition was 13.20&amp;plusmn;0.76 mm at the maximum concentration used (500 &amp;mu;g/mL) against &lt;em&gt;Escherichia coli&lt;/em&gt; ATCC-11229, and the minimum inhibitory concentration(MIC) for each bacteria was found to be 0.5&amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; The result of the study suggests that &lt;em&gt;B. rotunda&lt;/em&gt; rhizome contains potential bioactive compounds which could be suitable for antioxidant and the treatment of various infections caused by &lt;em&gt;Escherichia coli&lt;/em&gt; ATCC-11229, &lt;em&gt;Staphylococcus aureus&lt;/em&gt; ATCC- 25923, &lt;em&gt;Staphylococcus epidermidis&lt;/em&gt; FNCC-0048, and &lt;em&gt;Streptococcus mutans&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">513</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sri Atun&lt;sup&gt;1*&lt;/sup&gt;, Sri Handayani&lt;sup&gt;1&lt;/sup&gt;, Anna Rakhmawati&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology Education, Faculty of Mathematics and Natural Science, Universitas Negeri Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Robert Hotman Sirait</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">Syafri K.Arief</style></author><author><style face="normal" font="default" size="100%">Tigor P. Simanjuntak</style></author><author><style face="normal" font="default" size="100%">Bambang Suprayogi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Profile of HMGB1 mRNA Expression and TLR4 Protein in BALB/c Mice Model Sterile Injury after Systemic Lidocaine Administration</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HMGB1 mRNA</style></keyword><keyword><style  face="normal" font="default" size="100%">lidocaine</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterile injury</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR4</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/529</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">586-589</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; High mobility group box 1 (HMGB1) is a cytokine proinflamation which contributes to inflammation. HMGB1 physically interacts with toll like receptor 4 (TLR4) to release macrophage cytokines. The aim of this study was to demonstrate the effectiveness of systemic lidocaine administration to inhibit the expression of HMGB1 mRNA and TLR4 protein in mice BALB/c mice with sterile injury. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Twenty adult male BALB/c mice were divided into lidocaine and control groups. A sterile injury is done by closed fracturing the left thigh bone of the mice. The lidocaine group was treated with 2 mg/kgBW lidocaine through tail vein injection after 4 h of sterile injury. The control group was given distilled water therapy as a substitute for lidocaine. Mice blood is extracted from the tail vein before trauma, 4 h after trauma, and 2 h after the administration of lidocaine and distilled water is complete. The HMGB1 mRNA expression was examined by quantitative real-time polymerase chain reaction (qPCR) while the TLR4 protein level was determined with enzyme-linked immunosorbent assay (ELISA) according to the manufacturer&amp;rsquo;s instructions. &lt;strong&gt;Result:&lt;/strong&gt; The HMGB1 mRNA expression and TLR4 protein levels in BALB/c that sustained inflammation due to a sterile injury was significantly decreased in the lidocaine group (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.00). &lt;strong&gt;Conclusion:&lt;/strong&gt; Administration systemic 2 mg/kgBW of lidocaine is effectively inhibits HMGB1 mRNA and TLR4 protein in mice that sustain inflammation due to a sterile injury.&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">586</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Robert Hotman Sirait&lt;sup&gt;1&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;, Syafri K.Arief&lt;sup&gt;3&lt;/sup&gt;, Tigor P. Simanjuntak&lt;sup&gt;4&lt;/sup&gt;, Bambang Suprayogi&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Biology and Immunology Laboratory, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anesthesiology, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Obstetric and Gynecology, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Otorhinolaryngology, Faculty of Medicine, Christian University of Indonesia, Jakarta, Indonesia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thriveni Vasanthkumar</style></author><author><style face="normal" font="default" size="100%">Manjunatha Hanumanthappa</style></author><author><style face="normal" font="default" size="100%">Prabhakar BT</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of Dietary Curcumin and Capsaicin on LPS-Induced Inflammation in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Capsaicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid peroxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">LPS</style></keyword><keyword><style  face="normal" font="default" size="100%">Septic shock</style></keyword><keyword><style  face="normal" font="default" size="100%">Superoxide dismutase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/659</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">725-729</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aimed to evaluate the anti-inflammatory potency of combined curcumin and capsaicin against lipopolysaccharide (LPS) induced organ damage in mice. &lt;strong&gt;Methods:&lt;/strong&gt; Adult male albino mice were distributed into five experimental groups for treatment with olive oil, LPS, curcumin, capsaicin and their combination, respectively, for 7 days prior to LPS induced inflammation. At the end of the experiment, blood samples were collected and used for the analysis of serum non-specific enzymes including serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), total bilirubin (TB), urea, creatinine and sugar, while the organ homogenates were subjected for the evaluation of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutothione S transferase (GST), nitric oxide (NO); lipid peroxidation (LPO) and it was further confirmed by histopathological study of different organs. &lt;strong&gt;Results and Conclusion:&lt;/strong&gt; Curcumin, capsaicin and their combination had shown significant restoration of non-specific serum enzymes, antioxidant enzymes and attenuated inflammatory cells infiltration thereby preventing tissue/organ damage in LPS-challenged mice. However, the protective effect was found to be more when the two compounds were fed in combination. This beneficial potency of combined spice treatment is may be due to the contribution of diversified active moieties of curcumin and capsaicin in combination compared to individual molecules.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">75</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Thriveni Vasanthkumar&lt;sup&gt;1&lt;/sup&gt;, Manjunatha Hanumanthappa&lt;sup&gt;1&lt;/sup&gt;*, Prabhakar BT&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of PG Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta, Shimoga, Karnataka, INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular Biomedicine Laboratory, Postgraduate Department of Studies and Research in Biotechnology, Sahyadri Science college, Kuvempu University, Shimoga, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">La Hamidu</style></author><author><style face="normal" font="default" size="100%">Aktsar Roskiana Ahmad</style></author><author><style face="normal" font="default" size="100%">Ahmad Najib</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Qualitative and Quantitative Test of Total Flavonoid Buni Fruit (Antidesma bunius (L.) Spreng) with UV-Vis Spectrophotometry Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidesma bunius L. Spreng</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectrophotometry UV-VIS</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/367</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">60-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The aim of this research is to determine of total flavonoid content in the Buni fruit (&lt;em&gt;Antidesma bunius &lt;/em&gt;L. Spreng) extract. The extract was produced by stratified maceration method with the different solvent, i.e &lt;em&gt;n&lt;/em&gt;-Hexane, Ethyl acetate and ethanol. The analysis of chemical compound using chemical reagent and Thin Layer Chromatography (TLC) method. The method is used to determines total flavonoid contains Buni fruit (&lt;em&gt;Antidesma bunius&lt;/em&gt; L.) extract was based on the amount of Rutin Equivalent (RE) were used. The result shows that the flavonoid content higher in the &lt;em&gt;n&lt;/em&gt;-Hexane extract is 10.72 %, then ethyl acetate extract is 7.9 % and 3.56 % ethanol extract was counted to or as a Rutin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">60</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;La Hamidu&lt;sup&gt;1&lt;/sup&gt;*, Aktsar Roskiana Ahmad&lt;sup&gt;2&lt;/sup&gt;, Ahmad Najib&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Pharmacognosy-Phytochemistry Laboratory, Faculty of Pharmacy, Universities Muslim Indonesia, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Evi Sulastri</style></author><author><style face="normal" font="default" size="100%">Muhammad Sulaiman Zubair</style></author><author><style face="normal" font="default" size="100%">Nurafni Israyanti Anas</style></author><author><style face="normal" font="default" size="100%">Syakila Abidin</style></author><author><style face="normal" font="default" size="100%">Ririen Hardani</style></author><author><style face="normal" font="default" size="100%">Risfah Yulianti</style></author><author><style face="normal" font="default" size="100%">Aliyah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenolic, Total Flavonoid, Quercetin Content and Antioxidant Activity of Standardized Extract of Moringa oleifera Leaf from Regions with Different Elevation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Kelor</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s104-s108</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Moringa oleifera&lt;/em&gt; is the famous plant that has been used as medicinal plant for diverse pharmacological activity. &lt;strong&gt;Aims:&lt;/strong&gt; To evaluate the total phenolic, total flavonoid, quercetin content as well as the antioxidant activity of standardized extract of &lt;em&gt;Moringa oleifera&lt;/em&gt; (Lamk) leaf, collected from three regions with different elevation.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The leaves were extracted by maceration method using ethanol 96% and evaporated by rotary evaporator to obtain the viscous extract. The determination of total phenolic and total flavonoid were performed by spectroscopic method, while the quercetin concentration were determined by high performance liquid chromatography (HPLC). The antioxidant activity was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. &lt;strong&gt;Results:&lt;/strong&gt; Ethanolic extracts of &lt;em&gt;Moringa oleifera&lt;/em&gt; leaf from region with medium altitude (Sigi regency) showed higher total phenolic, total flavonoid, quercetin concentration and antioxidant activity than regions with low and high altitude (Parigi and Palu cities). &lt;strong&gt;Conclusion:&lt;/strong&gt; This study reveals the potency of standardized extracts of &lt;em&gt;Moringa oleifera&lt;/em&gt; growing in medium altitude (Sigi regency) to be developed as antioxidant herbal medicine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s104</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Evi Sulastri&lt;sup&gt;1&lt;/sup&gt;, Muhammad Sulaiman Zubair&lt;sup&gt;1,*&lt;/sup&gt;, Nurafni Israyanti Anas&lt;sup&gt;1&lt;/sup&gt;, Syakila Abidin&lt;sup&gt;1&lt;/sup&gt;, Ririen Hardani&lt;sup&gt;1&lt;/sup&gt;, Risfah Yulianti&lt;sup&gt;2&lt;/sup&gt;, Aliyah&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Sciences, Tadulako University, Kampus Bumi Tadulako, 94118, Palu, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Hasanuddin University, 90245, Makassar, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arunodaya Hosahalli Sumithregowda</style></author><author><style face="normal" font="default" size="100%">Krishna Venkatarangaiah</style></author><author><style face="normal" font="default" size="100%">Kumaraswamy Malleshappa Honnenahally</style></author><author><style face="normal" font="default" size="100%">Vinaykumar Nagenahalli Manjunath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity and Oral Acute Toxicity Studies of Litsea glutinosa C. B (ROB) Stem Bark Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast adenocarcinoma cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology.</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea glutinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/191</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">880-886</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Litsea glutinosa&lt;/em&gt; (Lauraceae) stem bark is widely used in folk medicine as a hepatoprotective, anti-diarrheal and anti-dysenteric drug but there is a lack of information about its toxicity. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate cytotoxicity and acute toxicity of the stem bark ethanol extract (BEE). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;In vitro&lt;/em&gt; cytotoxicity of BEE was measured against breast adenocarcinoma, prostate, and colon carcinoma cell lines. In the acute toxicity tests, rats received oral doses of BEE as 1000, 2000, and 3000 mg/kg body weight. Mortality, signs of toxicity, body weight, food consumption, and gross findings were observed for 14 days. Blood samples were collected from anesthetized animals and used for hematological and biochemical parameters. Histopathological study was performed using liver and kidney samples. &lt;strong&gt;Results:&lt;/strong&gt; The BEE does not show significant cytotoxic effect against the tested cell lines up to the range from 5 to 320 &amp;mu;g/ml. In acute toxicity study, also lethality was not observed up to 3000 mg/kg b.w. No significant differences were noticed in body and organ weights and histopathology examinations between the control and treated groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study authenticates stem BEE may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and evidences the medicinal use of this plant in folk medicine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">880</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arunodaya Hosahalli Sumithregowda, Krishna Venkatarangaiah&lt;sup&gt;*&lt;/sup&gt;, Kumaraswamy Malleshappa Honnenahally, Vinaykumar Nagenahalli Manjunath &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of PG Studies and Research in Biotechnology, Kuvempu University, Shankaraghatta 577 451, Shivamogga, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sonam Sharma</style></author><author><style face="normal" font="default" size="100%">Siva Hemalatha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">DNA Fingerprinting Profile and Quality Control Standardization of Folklore Medicinal Plant Exacum lawii</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DNA fingerprinting</style></keyword><keyword><style  face="normal" font="default" size="100%">Exacum lawii</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS.</style></keyword><keyword><style  face="normal" font="default" size="100%">Swertiamerin</style></keyword><keyword><style  face="normal" font="default" size="100%">Ursolic acid</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/175</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">775-785</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context and Aim:&lt;/strong&gt; &lt;em&gt;Exacum lawii &lt;/em&gt;(Gentianaceae) is bitter folk medicinal herb. The study deals with molecular investigation by DNA fingerprinting profile of &lt;em&gt;Exacum lawii&lt;/em&gt;, quality control and phytochemical standardization of &lt;em&gt;Exacum lawii&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; The DNA fingerprinting profile was performed by RAPD technique using 3 pairs of primers. The quality control standardization was done as per the WHO guidelines and official methods of AOAC. Phytochemical standardization employed quantitative estimations of phytoconstituents by spectrophotometric and identification using GCMS technique. The quantification of Swertiamerin and Ursolic acid in &lt;em&gt;Exacum lawii&lt;/em&gt; was carried by HPLC. &lt;strong&gt;Results:&lt;/strong&gt; Macroscopical and microscopical examination confirmed the diagnostic morphological and histological features. The content of vitamins, minerals and fatty acids were estimated. Physicochemical parameters obtained within the provided limits as per WHO. The phytochemical screening of ethanolic extract and its fraction revealed the presence of alkaloids, flavonoids, phenols, tannins, terpenoids, glycosides and steroids Total phenolics (57.4mg/g tannic acid equivalent), total tannins (15.3 mg/gm), total flavonoids (51.4 mg/gm rutin equivalent), total flavonols (5.4 mg/gm) and carbohydrates (12.6 mg/gm D-fructose equivalent) content were estimated using spectroscopic techniques. The GC-MS data revealed 20 compounds. Swertiamerin and Ursolic acid content was 119.59 mg/gm and 5.34 mg/gm respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; Present study provides the referential information to develop a monograph for quality control standardization of &lt;em&gt;Exacum lawii&lt;/em&gt;.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; &lt;em&gt;Exacum lawii&lt;/em&gt;, DNA fingerprinting, Swertiamerin, Ursolic acid, GC-MS.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">775</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sonam Sharma, Siva Hemalatha&lt;sup&gt;*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, Uttar Pradesh, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daniel Rodrigo Cavalcante de Araújo</style></author><author><style face="normal" font="default" size="100%">Luís Cláudio Nascimento da Silva</style></author><author><style face="normal" font="default" size="100%">Wolfgang Harand</style></author><author><style face="normal" font="default" size="100%">Júlia Morais Fernandes</style></author><author><style face="normal" font="default" size="100%">Thaciane da Cunha Soares</style></author><author><style face="normal" font="default" size="100%">Silvana Maria Zucolotto Langassner</style></author><author><style face="normal" font="default" size="100%">Raquel Brandt Giordani</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Alexandre Gomes da Silva</style></author><author><style face="normal" font="default" size="100%">Márcia Vanusa da Silva</style></author><author><style face="normal" font="default" size="100%">Maria Tereza dos Santos Correia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Semi arid area</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.73</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">435-440</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Anadenanthera colubrina&lt;/em&gt; (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of&lt;em&gt; A. colubrina&lt;/em&gt;. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Samples were collected in Catimbau National Park (Bu&amp;iacute;que, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. &lt;strong&gt;Results:&lt;/strong&gt; All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (&amp;rho;: -0.99), EALE (&amp;rho;: -0.81), CHFE (&amp;rho;: -0.81), EAFE (&amp;rho;: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. &lt;em&gt;colubrina&lt;/em&gt;, however these extracts showed more chemical diversity during dry months.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Daniel Rodrigo Cavalcante de Ara&amp;uacute;jo&lt;sup&gt;1&lt;/sup&gt;, Lu&amp;iacute;s Cl&amp;aacute;udio Nascimento da Silva&lt;sup&gt;2&lt;/sup&gt;, Wolfgang Harand&lt;sup&gt;3&lt;/sup&gt;, J&amp;uacute;lia Morais Fernandes&lt;sup&gt;4&lt;/sup&gt;, Thaciane da Cunha Soares&lt;sup&gt;4&lt;/sup&gt;, Silvana Maria Zucolotto Langassner&lt;sup&gt;4&lt;/sup&gt;, Raquel Brandt Giordani&lt;sup&gt;4&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;5&lt;/sup&gt;, Alexandre Gomes da Silva&lt;sup&gt;1&lt;/sup&gt;, M&amp;aacute;rcia Vanusa da Silva&lt;sup&gt;1&lt;/sup&gt;, Maria Tereza dos Santos Correia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Produtos Naturais, Departamento de Bioqu&amp;iacute;mica, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Mestrado em Biologia Parasit&amp;aacute;ria, Universidade CEUMA, Maranh&amp;atilde;o, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Instituto Nacional do Semi-&amp;Aacute;rido (INSA), Para&amp;iacute;ba, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Farm&amp;aacute;cia, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sridevi I Puranik</style></author><author><style face="normal" font="default" size="100%">Shridhar C Ghagane</style></author><author><style face="normal" font="default" size="100%">Rajendra B Nerli</style></author><author><style face="normal" font="default" size="100%">Sunil S Jalalpure</style></author><author><style face="normal" font="default" size="100%">Murigendra B. Hiremath</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antioxidant and Anticancer Activity of Simarouba glauca Leaf Extracts on T-24 Bladder Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant; Anticancer; Bladder Cancer; Phytochemical; Simarouba glauca.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/195</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">906-912</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Screening of preliminary phytochemicals, evaluation of &lt;em&gt;in vitro&lt;/em&gt; antioxidant and &lt;em&gt;in vitro&lt;/em&gt; anticancer activities of &lt;em&gt;Simarouba glauca&lt;/em&gt; leaf extracts on T-24 Bladder cancer cell line. Materials and &lt;strong&gt;Methods:&lt;/strong&gt; Herbal extraction was carried out by Soxhlet method using chloroform, ethylacetate, methanol, ethanol, aqueous and hydroalcohol. Phytochemical investigation was done using biochemical tests. Total phenolic content was estimated by Folin-Ciocalteu reagent (FCR) method. Antioxidant potential of leaf extracts was analyzed by Ferric ion reducing antioxidant power (FRAP) assay, Phosphomolybdenum (PM) assay and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. &lt;em&gt;In vitro&lt;/em&gt; anticancer activity on T-24 bladder cancer cell line was assessed by MTT assay. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; Statistical analysis of data was performed by analysis of variance (one-way ANOVA) and level of statistical significance between groups was carried out using GraphPad Prism version 5.0 for Windows (GraphPad Software, San Diego, CA, USA). &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis revealed the presence of rich secondary metabolite present in all the solvent extracts. Hydroalcoholic extract showed highest presence of phenolic content (92.38&amp;plusmn;0.29 mg/g) GAE. Ethanol and methanol extract showed highest antioxidant capacity in DPPH, FRAP and PM assay as compared to the other extracts based on the test performed. The results confirmed that ethanol extract significantly (p&amp;lt;0.05) inhibited T-24 cell line with IC50 value (533.55&amp;plusmn;25.02 &amp;mu;g/mL) as compared to standard drug doxorubicin (0.16&amp;mu;M/mL). &lt;strong&gt;Conclusions:&lt;/strong&gt; The results of the present findings strengthen the potential property of &lt;em&gt;Simarouba glauca&lt;/em&gt; as a resource for the discovery of novel antioxidant and anticancer agents.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">906</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sridevi I. Puranik&lt;sup&gt;1,2&lt;/sup&gt;, Shridhar C. Ghagane&lt;sup&gt;3&lt;/sup&gt;, Rajendra B. Nerli&lt;sup&gt;4&lt;/sup&gt;, Sunil S. Jalalpure&lt;sup&gt;5,6&lt;/sup&gt;, Murigendra B. Hiremath&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology and Microbiology, Karnatak University Dharwad-580003, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, K.L.E&amp;rsquo;S R. L. Science Institute (Autonomous), Belagavi-590001, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Urology, KLES Kidney Foundation, KLES Dr. Prabhakar Kore Hospital &amp;amp; Medical Research Centre, Belagavi-590001, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Urology, KLE University&amp;rsquo;s JN Medical College, KLES Kidney Foundation, KLES Dr. Prabhakar Kore Hospital &amp;amp; Medical Research Centre, Belagavi-590010, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;KLE University&amp;rsquo;s Dr. Prabhakar Kore Basic Science Research Centre, Belagavi- 590010, Karnataka, INDIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;KLE University&amp;rsquo;s College of Pharmacy, Nehru Nagar, Belagavi-590010, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Krishnendu Acharya</style></author><author><style face="normal" font="default" size="100%">Kanad Das</style></author><author><style face="normal" font="default" size="100%">Soumitra Paloi</style></author><author><style face="normal" font="default" size="100%">Arun Kumar Dutta</style></author><author><style face="normal" font="default" size="100%">Manoj Emanuel Hembrom</style></author><author><style face="normal" font="default" size="100%">Somanjana Khatua</style></author><author><style face="normal" font="default" size="100%">Arvind Parihar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Exploring a novel edible mushroom Ramaria subalpina: Chemical characterization and Antioxidant activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Ferrous ion chelating</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">India.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">30-34</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; During macrofungal inventorisation from an unexplored subalpine forest of Sikkim Himalayas, a new edible mushroom, &lt;em&gt;Ramaria subalpina&lt;/em&gt; was found and documented in consultation with the forest dwellers. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present study was to understand the antioxidative potentiality and bioactive constituents of a novel taxon, &lt;em&gt;Ramaria subalpina&lt;/em&gt;, that is highly prized by the ethnic people of subalpine Sikkim Himalayas, India, for its flavor, texture and gastronomic delicacy since time immemorial. &lt;strong&gt;Methods:&lt;/strong&gt; Chemical composition and antioxidant properties of methanolic extract of dried basidiocarps were assessed using HPLC and several in vitro assay systems. &lt;strong&gt;Results:&lt;/strong&gt; Methanolic extract had phenolics in highest amount, among which pyrrogallol was identified. It also showed potent antioxidant activity. Conclusion: The present study suggests that &lt;em&gt;Ramaria subalpina&lt;/em&gt; has strong medicinal prospects. This novel mushroom can safely be added to the world&amp;rsquo;s edible mushrooms list.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">30</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Krishnendu Acharya&lt;sup&gt;1*&lt;/sup&gt;, Kanad Das&lt;sup&gt;2&lt;/sup&gt;, Soumitra Paloi&lt;sup&gt;1&lt;/sup&gt;, Arun Kumar Dutta&lt;sup&gt;1&lt;/sup&gt;, Manoj Emanuel Hembrom&lt;sup&gt;3&lt;/sup&gt;, Somanjana Khatua&lt;sup&gt;1&lt;/sup&gt;, and Arvind Parihar&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, Molecular and Applied Mycology and Plant Pathology Laboratory, University of Calcutta, 35, Ballygunge Circular Road, Kolkata&amp;ndash;700019, West Bengal, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Cryptogamic Unit, Botanical Survey of India, P.O.&amp;ndash;Botanic Garden, Howrah&amp;ndash;711103, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Central National Herbarium, Botanical Survey of India, Central National Herbarium, P. O.&amp;ndash;Botanic Garden, Howrah &amp;ndash; 711103, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Thriveni Vasanthkumar</style></author><author><style face="normal" font="default" size="100%">Manjunatha Hanumanthappa</style></author><author><style face="normal" font="default" size="100%">Prabhakar BT</style></author><author><style face="normal" font="default" size="100%">Santhosh Kondajji Hanumanthappa</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Curcumin and Capsaicin against Lipopolysaccharide Induced Liver Damage in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ALP.</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsaicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Curcumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipopolysaccharide</style></keyword><keyword><style  face="normal" font="default" size="100%">SGOT</style></keyword><keyword><style  face="normal" font="default" size="100%">SGPT</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/201</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">947-951</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study was undertaken to evaluate the possible ameliorative role of curcumin, capsaicin and their combination against lipopolysaccharide (LPS) induced hepatic toxicity in mice. &lt;strong&gt;Methods:&lt;/strong&gt; Animals were distributed into five experimental groups: Normal control, vehicle control, curcumin, capsaicin and combined curcumin and capsaicin treatment groups respectively, for 7 days prior to LPS induced liver toxicity (3 mg/kg b.w. in saline). Hepatoprotective effect of individual and combined spice principles were evidenced by the measurement of serum marker enzyme activities such as, SGPT, ALP and TB and it was further confirmed by histopathological observation of liver tissue section. &lt;strong&gt;Results:&lt;/strong&gt; The administration of LPS increased serum nonspecific enzymes (SGOT; 174.2&amp;plusmn;3.79 IU/L, SGPT; 124.0&amp;plusmn;3.14 IU/L, ALP; 320.15&amp;plusmn;3.88 IU/L and total bilirubin level; 2.32&amp;plusmn;1.23 mg/dL), however dietary curcumin and capsaicin decreased the activities of these non&amp;ndash;specific serum enzymes including total bilirubin indicating amelioration of the severe LPS induced hepatotoxicity, while the combined spice principles were more significant as shown by the levels of enzymes activities SGOT; 89.9&amp;plusmn;1.39 IU/L, SGPT; 85.9&amp;plusmn;1.83 IU/L, ALP; 138.4&amp;plusmn;2.05 IU/L including total bilirubin level; 0.86&amp;plusmn;0.03 mg/dL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Dietary curcumin and capsaicin individually are protective to LPS induced hepatotoxicity, the beneficial effect was found to be more when the two compounds were fed in combination.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">947</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Thriveni Vasanthkumar&lt;sup&gt;1&lt;/sup&gt;, Manjunatha Hanumanthappa&lt;sup&gt;1&lt;/sup&gt;, Prabhakar BT&lt;sup&gt;2&lt;/sup&gt;, Santhosh Kondajji Hanumanthappa&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Kuvempu University, Shankaraghatta - 577 451 Shimoga, Karnataka (St), INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Molecular biomedicine laboratory, Postgraduate department of studies and research in biotechnology, Sahyadri science college, Kuvempu University, Shimoga-577203, Karnataka (St), INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rudra Pratap Singh</style></author><author><style face="normal" font="default" size="100%">Gangadharappa H.V.</style></author><author><style face="normal" font="default" size="100%">Mruthunjaya K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">&lt;i&gt;Cuminum cyminum&lt;/i&gt; – A Popular Spice: An Updated Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Cuminaldehyde</style></keyword><keyword><style  face="normal" font="default" size="100%">Cymene</style></keyword><keyword><style  face="normal" font="default" size="100%">Spice</style></keyword><keyword><style  face="normal" font="default" size="100%">Thymol</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.51</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">292-301</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Spices are bio-nutrient supplements that enhance the taste, flavor and aroma of food and also treat several diseases. Cumin (&lt;em&gt;Cuminum cyminum&lt;/em&gt;) is one such most popular spice that is used as a culinary spice for their special aromatic effect. Cumin is a traditional and much used spice from Middle Ages because it was an icon of love and fidelity. Cumin is available in different appearances such as anise, fennel and black cumin and the difference between them is their characteristics. The proximate analysis of the cumin seeds reveals that they contain fixed oil, volatile oils, acids, essential oils, protein and other elements. In cumin, contains an important component such as pinene, cymene, terpinene, cuminaldehyde, oleoresin, thymol and others that have shown their uses according to the disease. Cumin has proved several benefits with the help of availability of nutrients. It is an important element of iron for energy, immunity systems, lactation and skin diseases. Cumin also shown various pharmacological effects but has some side effects. So, volatile plants generally come out as a complex mixture of less molecular weight lipophilic compounds that derived from different biosynthetic pathways and also contribute to a variety of physiological functions.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Rudra Pratap Singh, Gangadharappa H.V.*, Mruthunjaya K &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagar, Mysuru, Karnataka, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Endang Hanani</style></author><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Lina Karlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Indonesian Mirabilis jalapa Linn. : A Pharmacognostical and Preliminary Phytochemical Investigations</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromatography Profile</style></keyword><keyword><style  face="normal" font="default" size="100%">Flourescence Character</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Nyctaginaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.108/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">683-688</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Mirabilis jalapa Linn.&lt;/em&gt; is an important medicinal plant and used extensively by the people from different countries for the treatment of several disorders. The plant was the raw material for the herb-drug product, so some parameters identified were needed to ensure the safety, quality and efficacy of the product. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study was to undertake pharmacognostical studies to fulfill the work required for the identification the &lt;em&gt;M. jalapa&lt;/em&gt; plant, which is collected from the Bogor area, Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; Macroscopic and microscopic evaluation, fluorescence standards, phytochemical screening and physicochemical parameters were carried out on the above plant. &lt;strong&gt;Results:&lt;/strong&gt; The parameters values of total ash, water soluble and acid insoluble ash were obtained 11.81, 5.06 and 0.41%, respectively. Moisture content, alcohol, water and ether soluble extractive were found to be 12.41, 11.02, 18.63 and 7.17% respectively. The results of preliminary phytochemical analysis of aqueous ethanolic extract of this drug were positive for alkaloids, tannins, flavonoids, steroid, triterpenoids, saponin, phenols, glycosides and carbohydrate. Thin layer chromatography (TLC) of alcoholic, chloroform and aqueous extracts showed 9, 7 and 4 spots respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study on botanical pharmacognosy and TLC profile of this plant above thus provides useful information for correct identification and quality control parameters for the crude drugs, and also will be useful in making monograph of the plant.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">683</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Endang Hanani*, Rini Prastiwi, Lina Karlina &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Faculty of Pharmacy and Sciences, University of Muhammadiyah Prof. Dr. HAMKA Jl. Delima II/IV Klender, Jakarta 13460, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Savin Chanthala Ganapathi</style></author><author><style face="normal" font="default" size="100%">Rajendra Holla</style></author><author><style face="normal" font="default" size="100%">Shivaraja Shankara</style></author><author><style face="normal" font="default" size="100%">Sunil Kumar Koppala Narayana</style></author><author><style face="normal" font="default" size="100%">Ravi Mundugaru</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Microscopical Evaluation, Phytochemical Analysis and HPTLC Fingerprinting of Tuber of Actinoscirpus grossus (L.f.) Goetgh. &amp; D.A.Simpson</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethanol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality control</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/pj-9-5/10.5530pj.2017.5.104/index.html</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">657-662</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Actinoscirpus grossus&lt;/em&gt; (L.f.) Goetgh. &amp;amp; D.A.Simpson (Cyperaceae), is a Perennial with long stolons and rhizomes ending in small tubers. It is popularly known as Kasheruk in Sanskrit. The plant is traditionally used as anti-diarrheal, anti-emetic, and tonic to the liver. In order to do the detail standardization of plant macro-microscopical observation, phytochemical analysis and HPTLC Finger printing of tuber was performed according to pharmacopoeia procedure. Microscopic analysis has showed thick-walled polygonal epidermal cells of young root stalk in surface view, elongated phloem parenchyma filled with starch grains, spiral to annular vessel fragments and simple starch grains scattered all over the powder. Phytochemical analysis showed presence of carbohydrate, coumarins, flavanoids, steroid, tannin, and terpenoid. Ethanol extract of plant were fingerprinted in toluene: ethyl acetate (7:3). The developed plates were visualized in UV 254, 366, and then derivatised with vanillin sulphuric acid and scanned under UV 254 and 366 nm. These specific identities will be useful in identification and authentication of the raw drug.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">657</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Savin Chanthala Ganapathi&lt;sup&gt;1&lt;/sup&gt;, Rajendra Holla&lt;sup&gt;2&lt;/sup&gt;, Shivaraja Shankara&lt;sup&gt;3&lt;/sup&gt;, Sunil Kumar Koppala Narayana&lt;sup&gt;4*&lt;/sup&gt;, Ravi Mundugaru&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, KVG Medical College and Hospital, Sullia, Dakshina Kannada, Karnataka, 574327. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, KS Hegde Medical Academy, NITTE University, Deralakatte, Mangalore, Karnataka, 575018. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, KVG Medical College &amp;amp; Hospital, Sullia, Dakshina Kannada, Karnataka, 574327. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Research Officer, Department of Pharmacognosy, Siddha Central Research Institute, Central Council for Research in Siddha, Arumbakkam, Chennai, 600106. INDIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;SDM Centre for Research in Ayurveda and Allied Sciences, Laxminarayana Nagar, Kuthpady, Udupi, Karnataka, 574118. INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Rawan El-Haj</style></author><author><style face="normal" font="default" size="100%">Dania Shoumar</style></author><author><style face="normal" font="default" size="100%">Rana Alaaeddine</style></author><author><style face="normal" font="default" size="100%">Yousra Fakhro</style></author><author><style face="normal" font="default" size="100%">Natalie Tawil</style></author><author><style face="normal" font="default" size="100%">Farah Shaer</style></author><author><style face="normal" font="default" size="100%">Amani Daher</style></author><author><style face="normal" font="default" size="100%">Natalie Awada</style></author><author><style face="normal" font="default" size="100%">Ali Sabra</style></author><author><style face="normal" font="default" size="100%">Khouloud Atwi</style></author><author><style face="normal" font="default" size="100%">Malak Khaled</style></author><author><style face="normal" font="default" size="100%">Raneem Messi</style></author><author><style face="normal" font="default" size="100%">Nour Abouzaher</style></author><author><style face="normal" font="default" size="100%">Mohamed Houri</style></author><author><style face="normal" font="default" size="100%">Samer Al Jallad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Current therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathy Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.72</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">425-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. &lt;strong&gt;Methods:&lt;/strong&gt; A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. &lt;strong&gt;Results:&lt;/strong&gt; One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients&amp;rsquo; quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. &lt;strong&gt;Conclusion:&lt;/strong&gt; Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Karim Raafat&lt;sup&gt;*&lt;/sup&gt;, Rawan El-Haj, Dania Shoumar, Rana Alaaeddine, Yousra Fakhro, Natalie Tawil, Farah Shaer, Amani Daher, Natalie Awada, Ali Sabra, Khouloud Atwi, Malak Khaled, Raneem Messi, Nour Abouzaher, Mohamed Houri and Samer Al Jallad &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, LEBANON,&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Neneng Siti Silfi Ambarwati</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Amarila Malik</style></author><author><style face="normal" font="default" size="100%">Muhamad Hanafi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic and Antimicrobial Studies of Garcinia latissima Miq. Leaves (Clusiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia Latissima</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostical</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituent</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.80</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">493-498</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Garcinia latissima &lt;/em&gt;Miq known as Dolo magota (Maluku), is a medicinal plant belonging to the family Clusiaceae. The purpose of the research was to explore the phytoconstituents present, pharmacognostic details, and their antimicrobial efficacy. &lt;strong&gt;Methods:&lt;/strong&gt; The preliminary phytochemical components were qualitatively examined using the standard method systems. The antimicrobial screening was carried out using the good diffusion method and the minimum inhibitory concentration (MIC) using dilution method. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening of different extract of &lt;em&gt;G. latissima &lt;/em&gt;Miq leaves revealed the presence of tannins, saponins, and alkaloids and the results were tabulated. The ethyl acetate and methanolic extracts from its leaves showed antimicrobial activity especially for&lt;em&gt; Bacillus subtilis&lt;/em&gt;, a positive bacteria; the hexane extract did not show any activity against the selected microba. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of the phytochemical and bio-efficacy study revealed most valuable information and also support the continued sustainable use of this leaves in the traditional system of medicine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">493</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Neneng Siti Silfi Ambarwati&lt;sup&gt;1*&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;2&lt;/sup&gt;, Berna Elya&lt;sup&gt;3*&lt;/sup&gt;, Amarila Malik&lt;sup&gt;4&lt;/sup&gt;, Muhamad Hanafi&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Health and Beauty, Faculty of Engineering, Jakarta State University, Jl. Rawamangun Muka, East Jakarta, INDONESIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok 16424, INDONESIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Microbiology- Biotechnology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, Depok 16424, INDONESIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences-LIPI, PUSPIPTEK, Serpong 15314, INDONESIA.&lt;/em&gt;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pinal A. Harde</style></author><author><style face="normal" font="default" size="100%">Mamta B. Shah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Studies and HPLC Analysis of Roots of Helicteres isora (L.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal,</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Helicteres isora</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Oleanolic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Sapogenins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.84</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">523-527</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The juice of roots of &lt;em&gt;Helicteres isora &lt;/em&gt;Linn. has been widely used as an antidiabetic in traditional medicine. &lt;strong&gt;Objective:&lt;/strong&gt; The present study deals with pharmacognostical studies and determination of oleanolic acid from the roots of &lt;em&gt;H. isora &lt;/em&gt;by new HPLC method. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Detailed study of morphological, microscopical characteristics, physicochemical parameters and phytochemical screening of roots were carried out. The sapogenins were isolated from the roots of &lt;em&gt;H. isora.&lt;/em&gt; RP-HPLC method was developed and validated for estimation of oleanolic acid from the sapogenins of roots of &lt;em&gt;H. isora.&lt;/em&gt; &lt;strong&gt;Results:&lt;/strong&gt; Detailed quality control parameters of roots of &lt;em&gt;H. isora&lt;/em&gt; were reported. Total content of oleanolic acid was 0.075%w/w from roots of &lt;em&gt;H.&lt;/em&gt; &lt;em&gt;isora determined&lt;/em&gt; by HPLC. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study is useful for accurate identification and authentication of roots of &lt;em&gt;H. isora.&lt;/em&gt; The HPLC method for determination of oleanolic acid from the roots of &lt;em&gt;H. isora &lt;/em&gt;is efficient, precise, reliable and sensitive and can be adopted for routine analysis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">523</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Pinal A. Harde &lt;sup&gt;1*&lt;/sup&gt; and Mamta B. Shah&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, C.K. Pithawalla Institute of Pharmaceutical Science and Research, Surat, Gujarat, INDIA. &lt;/em&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, L. M. College of Pharmacy, Ahmedabad, Gujarat, INDIA.&lt;/em&gt;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Dessy Arisanty</style></author><author><style face="normal" font="default" size="100%">Nelsi Fitri Hayaty</style></author><author><style face="normal" font="default" size="100%">Dian Ayu Juwita</style></author><author><style face="normal" font="default" size="100%">Almahdy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Sub-acute Toxicity Study of The Ethyl Acetate Fraction of Asam Kandis Rinds (Garcinia cowa Roxb.) on the Liver and Renal Function in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Creatinine serum</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa rinds</style></keyword><keyword><style  face="normal" font="default" size="100%">SGPT</style></keyword><keyword><style  face="normal" font="default" size="100%">Sub-acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight ratio of liver and kidney</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.58</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">345-349</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study investigated the sub acute toxicity of the ethyl acetate fraction of asam kandis (&lt;em&gt;Garcinia cowa Roxb&lt;/em&gt;) Rinds in mice. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Sub acute toxicity study was carried out by giving orally at dose 500, 1000 dan 2000 mg / kgBW extract to five mice at 21 days. Animals were observed individually for any clinical signs of toxicity or mortality for 14 days. Measured parameters were SGPT levels, serum creatinine levels, weight ratio of liver and kidney. Extract was given orally at dose 500, 1000 and 2000 mg/kgBW for 21 days. Observations were done on day 8th, 15th and 22th using blood serum, liver and kidneys of mice. Data were analyzed by using two-way ANOVA followed by Duncan&amp;rsquo;s Multiple Range Test. &lt;strong&gt;Results:&lt;/strong&gt; The ethyl acetate fraction of &lt;em&gt;G. cowa&lt;/em&gt; at doses 500, 1000 and 2000 mg/kgBW gave significant effect on increasing SGPT levels and decreasing levels of serum creatinine (p &amp;lt;0.05). The length of treatment gave significant effect on decreasing levels of serum creatinine, weight ratio of liver and kidney (p &amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; The dosage of the ethyl acetate fraction of asam kandis rinds provides significant effect on the SGPT and serum creatinine levels of male white mice. The duration of administration of ethyl acetate fraction of asam kandis rinds provides significant effect on serum creatinine levels, the weight ratio of liver and kidney organ of male white mice.&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">345</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Dessy Arisanty&lt;sup&gt;2&lt;/sup&gt;, Nelsi Fitri Hayaty&lt;sup&gt;1&lt;/sup&gt;, Dian Ayu Juwita&lt;sup&gt;1&lt;/sup&gt;, Almahdy&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, West Sumatera, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Andalas University, West Sumatera, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Atun</style></author><author><style face="normal" font="default" size="100%">Sri Handayani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of Nanoparticles Produced by Ethanol Extract of Boesenbergia rotunda Rhizome Loaded with Chitosan and Alginic Acid and its Biological Activity test</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">alginic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">B. rotunda</style></keyword><keyword><style  face="normal" font="default" size="100%">chitosan-alginic acid combination</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles chitosan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/291</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">142-147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;B. rotunda&lt;/em&gt; used as a traditional medicine to treat illnesses such as rheumatism, muscle pain, febrifuge, gout, gastrointestinal disorders, flatulence, carminative, stomach ache, dyspepsia, and peptic ulcer. To enhance the stability, solubility and activity of the extract &lt;em&gt;B. rotunda&lt;/em&gt;, should be developed into a product nanoparticles. &lt;strong&gt;Objective:&lt;/strong&gt; This work reports the synthesis of nanoparticles produced by ethanol extract of &lt;em&gt;Boesenbergia rotunda&lt;/em&gt; rhizome loaded with chitosan and alginic acid, and its biological activity test as antioxidant. &lt;strong&gt;Method:&lt;/strong&gt; The synthesis of nanoparticles used an ionic gelation. Activity of the nanoparticle products as antioxidant was tested by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. &lt;strong&gt;Results:&lt;/strong&gt; This work showed that nanoparticles chitosan produced by ethanol extract &lt;em&gt;B. rotunda&lt;/em&gt; can be synthesized at a concentration (% w/v) of chitosan/ Na-TPP (sodium tripolyphosphate) and ratio of 8: 1, the size range of the nanoparticles were 389 to 877 nm, with a zeta potential of + 41.87 mV, and precentage nanoparticle 98.1%. The corresponding nanoparticles alginic acid can be synthesized at a concentration (% w/v) of alginic acid/ Ca2+ and ratio of 5: 1, the size range of the nanoparticles were 197 to 877 nm, with a zeta potential of -82.1 mV, and precentage nanoparticle 90.2%. Furthermore, nanoparticles result of the combination of alginic acid &amp;ndash;chitosan can be synthesized at a concentration (% w/v) alginic acid/chitosan/ca2+ and ratio of 6.7: 2: 1, the size range of the nanoparticle were 226 to 877 nm, and precentage nanoparticle 29.7%. The morphology of each nanoparticle products was spherical and a smooth surface. The chitosan-alginic acid nanoparticles show higher activity than the starting material ethanol extract of&lt;em&gt; B. rotunda.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">142</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sri Atun*, Sri Handayani &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Chemistry Education, Faculty Mathematics and Natural Science, Yogyakarta State University Jl. Colombo No. 1 Depok, Sleman, Yogyakarta, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Paula Carrión-Prieto</style></author><author><style face="normal" font="default" size="100%">Pablo Martín-Ramos</style></author><author><style face="normal" font="default" size="100%">Salvador Hernández-Navarro</style></author><author><style face="normal" font="default" size="100%">Iosody Silva-Castro</style></author><author><style face="normal" font="default" size="100%">Manuela Ramos-Silva</style></author><author><style face="normal" font="default" size="100%">Jesús Martín-Gil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vibrational Analysis and Thermal Behavior of Salvia hispanica, Nigella sativa and Papaver somniferum Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ATR-FTIR</style></keyword><keyword><style  face="normal" font="default" size="100%">Black cumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chia</style></keyword><keyword><style  face="normal" font="default" size="100%">Poppy</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/293</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">157-162</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Salvia hispanica&lt;/em&gt; L., &lt;em&gt;Nigella sativa&lt;/em&gt; L. and &lt;em&gt;Papaver somniferum&lt;/em&gt; L. are involved in opiate-dependent behavior. It is known that the seeds of these three herbs contain high amounts of antioxidants, which are helpful in disease prevention, but further research is needed on some of their other phytochemical components (terpene alkaloids, benzoquinones and others), which are claimed to affect human opioid receptors. &lt;strong&gt;Methods:&lt;/strong&gt; Seeds from the three afore mentioned plants have been studied by ATR-FTIR vibrational spectroscopy and thermo analytical techniques (TG/DTG, DTA and DSC). &lt;strong&gt;Results:&lt;/strong&gt; The infrared spectrum has confirmed the presence of the ester carbonyl of terpenoid alkaloids (such as nigellamine) and the fully conjugated cyclic dione structure of quinones (e.g., thymoquinone). As regards the thermal stability of these seeds, small differences have been observed in their thermal profiles (endothermic effects at around 333&amp;ordm;C for chia, 268&amp;ordm;C for black cumin and 319&amp;ordm;C for poppy seeds), which can be ascribed to their different content in carbohydrates. &lt;strong&gt;Conclusions:&lt;/strong&gt; The functional groups of the main active constituents and the thermal behavior of these three seeds have been elucidated.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">157</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Paula Carri&amp;oacute;n-Prieto,&lt;sup&gt;1&lt;/sup&gt; Pablo Mart&amp;iacute;n-Ramos,&lt;sup&gt;2&lt;/sup&gt;* Salvador Hern&amp;aacute;ndez-Navarro,&lt;sup&gt;1&lt;/sup&gt; Iosody Silva-Castro,&lt;sup&gt;1&lt;/sup&gt; Manuela Ramos- Silva,&lt;sup&gt;3&lt;/sup&gt; Jes&amp;uacute;s Mart&amp;iacute;n-Gil&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Agriculture and Forestry Engineering Department, ETSIIAA, Universidad de Valladolid, Avenida de Madrid 44, 34004 Palencia, SPAIN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Agricultural and Environmental Sciences, Higher Polytechnic School of Huesca, University of Zaragoza, Carretera de Cuarte, s/n, 22071 Huesca, SPAIN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;CFisUC, Department of Physics, University of Coimbra, Rua Larga, P-3004-516 Coimbra, Portugal.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Yakoob</style></author><author><style face="normal" font="default" size="100%">Nargis Begum Tajuddin</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas Mohammed Hussain</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Archunan Govindaraju</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Hypoglycemic Activities of Clausena anisata (Willd.) Hook F. Ex Benth. Root Mediated Synthesized Silver Nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">C. anisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Glucose and Silver nitrate</style></keyword><keyword><style  face="normal" font="default" size="100%">Silvernanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">579-586</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The present study was carried out to examine the hypoglycemic effect of Silver Nanoparticles (SNPs) using ethanolic root extract of &lt;em&gt;Clausena anisata&lt;/em&gt; (Willd.) Hook. f. ex Benth. A cost effective and eco friendly technique for green synthesis of SNPs from 1mM AgNO&lt;sub&gt;3&lt;/sub&gt; solution through the root extract was carried out. The biosynthesized SNPs were characterized using UV spectrophotometry, Field Emission Scanning Electron Microscopy (FESEM), X-ray Diffraction analysis (XRD), Energy Dispersive Spectroscopy (EDS) and Fourier transform infra-red (FTIR) spectrometry. DPPH assay was done to determine the antioxidant activity and for &lt;em&gt;in vitro&lt;/em&gt; hypoglycemic activity glucose uptake by yeast cells, alpha amylase inhibition assay, adsorption capacity and glucose diffusion assay was performed. The SNPs of ethanolic root extract were found to be spherical in shape and up to 32.75 nm average in size. They showed alpha amylase inhibitory activity of 83.60% at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The glucose uptake by yeast cells was found to increase with an increase in concentration. The maximum glucose uptake was found to be 69.51% at 10mM concentration. The molar concentration of glucose was directly proportional to the glucose binding capacity of extracts.The rate of glucose diffusion across the membrane was found to increase from 30 to 180 minutes. The DPPH scavenging activity was found to be potent (74.07%) at 500 &lt;em&gt;&amp;mu;&lt;/em&gt;g/ml. The hypoglycemic effect exhibited by the SNPs was revealed by simple in vitro model of yeast cells, mediated by glucose adsorption, increasing glucose diffusion and glucose transport across the cell membrane.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">579</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Yakoob&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum Tajuddin&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas Mohammed Hussain&lt;sup&gt;2&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Ishtiaq Qadri&lt;sup&gt;3&lt;/sup&gt;* and Archunan Govindaraju&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department Of Biotechnology, Jamal Mohamed College (Autonomous), Trichy- 20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department Of Botany, Jamal Mohamed College (Autonomous), Trichy- 20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;King Fahad Medical Research Centre, King Abdul Aziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Center For Pheromone Technology, Department Of Animal Science, Bharathidasan University Tiruchirappalli-620 024, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Yakoob</style></author><author><style face="normal" font="default" size="100%">Nargis Begum Tajuddin</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas Mohammed Hussain</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gc-Ms Analysis of Ethanolic Stem Extract of Clausena anisata (Willd.) Hook F Ex Benth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">C. anisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">maceration and phytoconstituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">576-578</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; In the present study, the bioactive components present in the ethanol stem extract of &lt;em&gt;Clausena anisata&lt;/em&gt; was analyzed by using Gas Chromatography Mass Spectrometry analysis technique (GC-MS). &lt;em&gt;Clausena anisata&lt;/em&gt;, a medicinal plant belonging to the family &lt;em&gt;Rutaceae&lt;/em&gt;, is represented by 20 species available in India and used traditionally for the treatment of several ailments but there is a requirement to identify its phytoconstituents, its target, mode of action and treatment using plant products either alone or in combination with synthetic drugs. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;Clausena anisata&lt;/em&gt; stem was procured from Manamettupatti, a village of Pudukottai District, Tamil Nadu. The shade dried stem was powdered and extracted using ethanol by maceration method. One microlitre of the extract was subjected to GC-MS analysis to detect the presence of bioactive compounds present in the stem of &lt;em&gt;C. anisata&lt;/em&gt;.&lt;strong&gt; Results:&lt;/strong&gt;The results showed that the ethanol stem extract of &lt;em&gt;C. anisata&lt;/em&gt; contained nine bioactive compounds, of which the major one is n-hexadecanoic acid (78.54%), followed by 8-octadecenoic acid, methyl ester, [E]- (6.638%). The total number of compounds obtained was compared with National Institutes of Standard and Technology (NIST) library that contains more than 62,000 known compounds based on retention time and molecular mass. &lt;strong&gt;Conclusion: &lt;/strong&gt;In this study, nearly nine compounds have been identified from the ethanolic stem extract of &lt;em&gt;C. anisata &lt;/em&gt;using GC-MS analysis which was mainly composed of fatty acids and sterols. The GC-MS analysis is used to understand the nature of active principles present in this plant revealed that the plant can be used as a potential source of new useful drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">576</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Yakoob&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum Tajuddin&lt;sup&gt;1&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas Mohammed Hussain&lt;sup&gt;1&lt;/sup&gt;, Ishtiaq Qadri&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Jamal Mohamed College (Autonomous), Trichy, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Kau University, Jeddah, K.S.A.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Han-jing Yan</style></author><author><style face="normal" font="default" size="100%">Meng-ling He</style></author><author><style face="normal" font="default" size="100%">Wei-Jian Huang</style></author><author><style face="normal" font="default" size="100%">Dong-mei Li</style></author><author><style face="normal" font="default" size="100%">Xiao-fang Yu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Induction of hairy roots and plant regeneration from the medicinal plant Pogostemon Cablin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Agrobacterium rhizogenes</style></keyword><keyword><style  face="normal" font="default" size="100%">ATCC15834.</style></keyword><keyword><style  face="normal" font="default" size="100%">C58C1</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant regeneration</style></keyword><keyword><style  face="normal" font="default" size="100%">Pogostemon cablin.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">50-55</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;An efficient transformation system for the medicinal and aromatic plant, &lt;em&gt;Pogostemon cablin &lt;/em&gt;Benth was developed by using &lt;em&gt;Agrobacterium rhizogenes &lt;/em&gt;ATCC15834 and C58C1. Hairy roots formed directly from the cut edges of leaf explants after infection for 2 days. The highest frequency of leaf explant transformation by &lt;em&gt;A. rhizogenes&lt;/em&gt; ATCC15834 and C58C1 were 83.3% and 80.5% after pre culture about 2 days and infection by the bacterium containing 15 mg l&lt;sup&gt;-1 &lt;/sup&gt;acetosyringone about 25 min. The PCR ampliﬁcation showed that rolB genes of Ri plasmid of &lt;em&gt;A. rhizogenes&lt;/em&gt; were integrated and expressed into the genome of transformed hairy roots. The optimum medium for callus induction of hairy roots consisted of 2.0 mg l&lt;sup&gt;-1&lt;/sup&gt; benzyladenine (BA) and 0.1 mg l&lt;sup&gt;-1&lt;/sup&gt; a-naphthaleneacetic acid (NAA); while optimum medium for adventitious shoot regeneration from these cultures consisted of 0.1 mg l&lt;sup&gt;-1&lt;/sup&gt; BA and 0.1 mg l&lt;sup&gt;-1&lt;/sup&gt; NAA. Adventitious shoots could be rooted on 1/2MS. PCR analysis conﬁrmed that rol genes of TL-DNA of Ri plasmid was integrated with at least three copies into the genome of hairy roots-regenerated &lt;em&gt;P. cablin&lt;/em&gt; plants. The results presented provide a possibility for breeding of a new cultivar of &lt;em&gt;P. cablin.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">50</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Han-Jing Yan&lt;sup&gt;1*&lt;/sup&gt;, Meng-ling He&lt;sup&gt;1&lt;/sup&gt;, Wei-Jian Huang&lt;sup&gt;1&lt;/sup&gt;, Dong-mei Li&lt;sup&gt;2&lt;/sup&gt; and Xiao-fang Yu&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Center, Guangzhou Guangdong, 510006 China.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Shunde Polytechnic, Foshan 528300, China.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of foreign languages, Guangdong Pharmaceutical University, Guangzhou Guangdong, 510006 China.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vijaya Anand</style></author><author><style face="normal" font="default" size="100%">Manikandan</style></author><author><style face="normal" font="default" size="100%">Vijaya Kumar</style></author><author><style face="normal" font="default" size="100%">Sampath Kumar</style></author><author><style face="normal" font="default" size="100%">Pushpa</style></author><author><style face="normal" font="default" size="100%">Agaath Hedina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmacological overview of Psidium guajava Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Psidium guajava</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">314-320</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Psidium guajava &lt;/em&gt;Linn. possesses useful medicinal benefits. It has been recognized as the medicinally essential phytoconstituents, such as phenolic, flavonoid and carotenoid. Numerous pharmacological investigation have confirmed that the ability of this plant is to exhibit antimicrobial, antidiabetic, cardioprotective, neuroprotective, hepatoprotective, antioxidant and anticancer activities and it supports the traditional uses. This is a comprehensive of the phytoconstituents and pharmacological benefits.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">314</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Vijaya Anand&lt;sup&gt;1&lt;/sup&gt;, Manikandan&lt;sup&gt;2&lt;/sup&gt;, Vijaya Kumar&lt;sup&gt;2&lt;/sup&gt;, Sampath Kumar&lt;sup&gt;3&lt;/sup&gt;, Pushpa&lt;sup&gt;4&lt;/sup&gt;, Agaath Hedina&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Genetics and Molecular Biology, Bharatiar University, Coimbatore-641 046, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, M.I.E.T. Arts and Science College,Tiruchirappalli-620 007, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry and Biosciences, SASTRA University, Kumbakonam-612 001, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Microbiology, Cauvery College for Women, Tiruchirappalli-620 018,Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Agaath Hedina</style></author><author><style face="normal" font="default" size="100%">Punniya Kotti</style></author><author><style face="normal" font="default" size="100%">Juveriyah Kausar</style></author><author><style face="normal" font="default" size="100%">Sivasamy</style></author><author><style face="normal" font="default" size="100%">Vijaya Anand</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmacological overview of Terminalia chebula Retz</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-arthritic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-carcinogenic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-fungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory.</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Free radical</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Renoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Terminalia chebula</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">307-309</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Phytotherapy is the traditional method used to cure many diseases. Various medicinal plants found in many parts of India are well known for their various medicinal values. The &lt;em&gt;Terminalia chebula&lt;/em&gt; Retz. a native plant of Asia is found to have various properties like anti-oxidant and free radical scavenging activity, anti-carcinogenic activity, ant-imutagenic activity, anti-bacterial activity, anti-fungal activity, anti-viral activity, anti-diabetic, renoprotective activity, cardio-protective activity, anti-inflammatory and anti-arthritic activity. These properties of &lt;em&gt;T. chebula&lt;/em&gt; discussed in this review are mainly due to the presence of various types of phytoconstituents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">307</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Agaath Hedina&lt;sup&gt;1&lt;/sup&gt;, Punniya Kotti&lt;sup&gt;2&lt;/sup&gt;, Juveriyah Kausar&lt;sup&gt;1&lt;/sup&gt;, Sivasamy&lt;sup&gt;1&lt;/sup&gt;, Vijaya Anand&lt;sup&gt;1&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Kanchi Shri Krishna College of Arts and Science, Kancheepuram, Tamil Nadu, INDIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Siva Hemalatha</style></author><author><style face="normal" font="default" size="100%">Priyanka Sharma</style></author><author><style face="normal" font="default" size="100%">Satyendra Kuldip Prasad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quality Control standardization of Wild Himalayan Pear: Pyrus pashia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">HPLC.</style></keyword><keyword><style  face="normal" font="default" size="100%">Lupeol</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyrus pashia</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword><keyword><style  face="normal" font="default" size="100%">total flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">352-360</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;To establish the pharmacognostical and phytochemical standardization parameters of &lt;em&gt;Pyrus pashia&lt;/em&gt; fruits in order to ensure quality and safety of this traditionally acclaimed medicinal tree. &lt;strong&gt;Methods:&lt;/strong&gt; The fresh fruits of &lt;em&gt;P. pashia &lt;/em&gt;were collected and dried. Fruit was subjected to various pharmacognostical investigations, Extraction procedures, and preliminary phytochemical screening, according to WHO guidelines. Ethanolic extract was standardized to total phenolic and flavonoid content, followed by phytochemical quantification of &lt;em&gt;P. pashia&lt;/em&gt; extract using lupeol as a chemical marker by HPLC method. &lt;strong&gt;Results: &lt;/strong&gt;In the present study, microscopy of the fruit showed typical characteristics of berry, having thick fleshy pericarp differentiated into thin epicarp and thick mesocarp having wide radiating carpel chambers with one or two seeds attached in axile placentum. Further, physicochemical evaluation was done like, loss on drying, total ash value, acid insoluble ash value, water soluble ash value, fluorescence analysis etc. Heavy metal and pesticide residue analysis was also performed. Furthermore, ethanolic extract of &lt;em&gt;Pyrus pashia&lt;/em&gt; (EPP) obtained from cold maceration and phytochemical screening of different fractions obtained by liquid partitioning revealed the presence of various secondary metabolites such as glycosides, steroids, triterpenoids, phenols flavonoids etc. Moreover, the total phenolic content and total analysis revealed that fruits are rich source of phenols and flavonoid. The HPLC chromatogram suggested that EPP contained 4.24% w/w of lupeol. &lt;strong&gt;Conclusion:&lt;/strong&gt; Pharmacognostical and phytochemical investigation will ensure quality and safety of this medicinal plant, furthermore HPLC quantification will aid in authentication and development of monograph.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">352</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Siva Hemalatha&lt;sup&gt;1&lt;/sup&gt;*, Priyanka Sharma&lt;sup&gt;1&lt;/sup&gt;, Satyendra Kuldip Prasad&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi-221005, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Rashtrakant Tukadoji Maharaj Nagpur University, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Juveriyah Kausar</style></author><author><style face="normal" font="default" size="100%">Durai Muthumani</style></author><author><style face="normal" font="default" size="100%">Agaath Hedina</style></author><author><style face="normal" font="default" size="100%">Sivasamy</style></author><author><style face="normal" font="default" size="100%">Vijaya Anand</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review of the phytochemical and pharmacological activities of Euphorbia hirta Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-apoptotic.</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-bacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Diuretic</style></keyword><keyword><style  face="normal" font="default" size="100%">Euphorbia hirta</style></keyword><keyword><style  face="normal" font="default" size="100%">Sedative</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">310-313</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The use of plant extract to cure diseases has been the traditional way used in many parts of the world. The synthetic drugs used now are more prone to cause side effects than curing the disease. Hence, the use of plant extract has now emerged due to their effective action against the disease without causing any side effects. The plants belonging to the family called Euphorbia are widely used in medicine for its wide medicinal properties. The plant &lt;em&gt;Euphorbia hirta&lt;/em&gt; has properties like anti-bacterial, anti-diarrheal, anti-allergic, diuretic, anti-oxidant, anti-tumor, anti-diabetic, anxiolytic and sedative activity. This review contains the detailed information about all the properties of &lt;em&gt;E. hirta.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">310</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Juveriyah Kausar &lt;sup&gt;1&lt;/sup&gt;, Durai Muthumani &lt;sup&gt;2&lt;/sup&gt;, Agaath Hedina &lt;sup&gt;1&lt;/sup&gt;, Sivasamy &lt;sup&gt;1&lt;/sup&gt;, Vijaya Anand &lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Human Genetics and Molecular Biology, Bharatiar University, Coimbatore &amp;ndash; 641 046, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Kanchi Shri Krishna College of Arts and Science, Kilambi,&amp;nbsp;Kancheepuram &amp;ndash; 631 551, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abirami Hariharan</style></author><author><style face="normal" font="default" size="100%">Tajuddin Nargis Begum</style></author><author><style face="normal" font="default" size="100%">Mohamed Hussain Muhammad Ilyas</style></author><author><style face="normal" font="default" size="100%">Hussain Syed Jahangir</style></author><author><style face="normal" font="default" size="100%">Premkumar Kumpati</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Archunan Govindaraju</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of Plant Mediated gold Nanoparticles using Azima Tetracantha Lam. Leaves extract and Evaluation of their Antimicrobial Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial Activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Azima tetracantha Leaves Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Biosynthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Gold Nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">507-512</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The demand for nanoparticles is increasing day by day due to their wide range of applications in various areas including pharmaceutical industry. Nanoparticles are formally synthesized by chemical methods in which the toxic and flammable chemicals are used. &lt;strong&gt;Methods: &lt;/strong&gt;This article reports about an effective, rapid and eco-friendly technique for the fabrication of gold nanoparticles from gold chloride solution using &lt;em&gt;Azima tetracantha&lt;/em&gt; Lam. leaves extract. The effects of the leaves extract of &lt;em&gt;Azima tetracantha&lt;/em&gt;, the concentration of Gold chloride solution, the time of the reaction and the effect of tem&amp;not;perature on the rate of the reaction were investigated. The synthesized gold nanoparticles (AuNPs) were characterized by using various techniques such as Dynamic Light Spectroscopy (DLS), Scanning Electron Microscopy (SEM), UV-Vis spectra gave surface plasmon resonance (SPR) at 540 nm, Fourier Transform Infrared spectroscopy (FTIR) and X-ray diffraction (XRD). This revealed the reduction of gold ions (Au&lt;sup&gt;+&lt;/sup&gt;) to gold metal (Au&lt;sup&gt;0&lt;/sup&gt;) which indicated the formation of gold nanoparticles (AuNPs). &lt;strong&gt;Results:&lt;/strong&gt; The antimicrobial action of biosynthesized AuNPs indicated effective activity against bacterial pathogens &lt;em&gt;Aeromonas liquefaciens&lt;/em&gt;, &lt;em&gt;Enterococcus fecalis&lt;/em&gt;, &lt;em&gt;Micrococcus luteus&lt;/em&gt;, &lt;em&gt;Salmonella typhimurium&lt;/em&gt; and fungal pathogens &lt;em&gt;Candida albicans&lt;/em&gt;, &lt;em&gt;Cryptococcus sp, Microsporum canis, Trichophyton rubrum&lt;/em&gt;.&lt;strong&gt; Conclusion:&lt;/strong&gt; This revealed that gold nanoparticles could provide a safer alternative to conventional antimicrobial agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">507</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Abirami Hariharan&lt;sup&gt;1&lt;/sup&gt;, Tajuddin Nargis Begum&lt;sup&gt;2&lt;/sup&gt;, Mohamed Hussain Muhammad Ilyas&lt;sup&gt;3&lt;/sup&gt;, Hussain Syed Jahangir&lt;sup&gt;3&lt;/sup&gt;, Premkumar Kumpati&lt;sup&gt;4&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;2&lt;/sup&gt;, Archunan Govindaraju&lt;sup&gt;5&lt;/sup&gt;, and Ishtiaq Qadri&lt;sup&gt;6*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;1Department of Biotechnology, Cauvery College for Women, Trichy- 18, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biotechnology, Jamal Mohamed College (Autonomous), Trichy-20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Botany, Jamal Mohamed College (Autonomous), Trichy-20, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biomedical Sciences, Bharathidasan University, Trichy-24, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Animal Science, Center for Pheromone Technology, Bharathidasan University Tiruchirappalli-620 024, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;King Fahad Medical Research Centre, King Abdul Aziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yi-ming Li</style></author><author><style face="normal" font="default" size="100%">Yan-Ru Liu</style></author><author><style face="normal" font="default" size="100%">Bing-Kun Xiao</style></author><author><style face="normal" font="default" size="100%">Jian-Yun Yang</style></author><author><style face="normal" font="default" size="100%">Rong-Qing Huang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Dynamic Comparison of Free Radical Scavenging Abilities of Hypericum Perforatum L., Herba Verbenae Officinalis, and Valeriana Officinalis L. Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS•+</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH•</style></keyword><keyword><style  face="normal" font="default" size="100%">Herba Verbena Officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypericum perforatum L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopause Oxidative Stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Valeriana officinalis L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">198-204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The purpose of this research was to compare the dynamic antioxidant activities and the free radical scavenging abilities of three botanical supplements, &lt;em&gt;Hypericum perforatum L&lt;/em&gt;. (HPL),&lt;em&gt; Herba Verbena Officinalis &lt;/em&gt;(HVO), and &lt;em&gt;Valeriana officinalis L. &lt;/em&gt;(VO), which have been reported to effectively treat menopause symptoms. &lt;strong&gt;Methods:&lt;/strong&gt; The antioxidant activities of the three supplements were determined by the ferric reducing ability of plasma (FRAP) assay. In addition, their free radical scavenging abilities were studied by ftheir interactions with the stable radicals of 2, 2&amp;rsquo;-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). &lt;strong&gt;Results: &lt;/strong&gt;The results indicated that the HPL ethanolic extract exhibited greater antioxidant activity (1.2688 &amp;plusmn; 0.01 mmol Trolox/g) than the HVO ethanolic extract (1.1686&amp;plusmn; 0.043 mmol Trolox/g) and the VO ethanolic extract (0.2579 &amp;plusmn; 0.0031 mmol Trolox/g) as compared to Nilestriol (0.0026&amp;plusmn;0.0012), a positive control agent in the experiment. Moreover, the HPL extract showed remarkable free radical scavenging activity against ABTS&lt;strong&gt;&amp;bull;&lt;/strong&gt;+, and the HVO extract was the most potent against DPPH&lt;strong&gt;&amp;bull;&lt;/strong&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These activities may be attributed to the total flavonoid or phenolic acid contents of among these extracts.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;ABTS&amp;bull;+, DPPH&amp;bull;,&lt;em&gt; Hypericum perforatum L.,&lt;/em&gt;&lt;em&gt;Herba Verbena Officinalis&lt;/em&gt;, Menopause Oxidative Stress, &lt;em&gt;Valeriana officinalis L.&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">198</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Yi-ming Li&lt;sup&gt;1&lt;/sup&gt;,Yan-Ru Liu&lt;sup&gt;2,3&lt;/sup&gt;, Bing-Kun Xiao&lt;sup&gt;2&lt;/sup&gt;, Jian-Yun Yang&lt;sup&gt;2&lt;/sup&gt;, Rong-Qing Huang&lt;sup&gt;2* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anhui Medical University,Hefei 230032, P. R.China;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Beijing Institute of Radiation Medicine, Haidian District, Beijing 100850, P.R. China;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;The School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenhe District, Shenyang 110016, P.R. China&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yi-ming Li</style></author><author><style face="normal" font="default" size="100%">Yan-Ru Liu</style></author><author><style face="normal" font="default" size="100%">Bing-Kun Xiao</style></author><author><style face="normal" font="default" size="100%">Jian-Yun Yang</style></author><author><style face="normal" font="default" size="100%">Rong-Qing Huang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Dynamic Comparison of Free Radical Scavenging Abilities of Hypericum Perforatum L., Herba Verbenae Officinalis, and Valeriana Officinalis L. Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS•+</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH•</style></keyword><keyword><style  face="normal" font="default" size="100%">Herba Verbena Officinalis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypericum perforatum L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopause Oxidative Stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Valeriana officinalis L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">198-204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; The purpose of this research was to compare the dynamic antioxidant activities and the free radical scavenging abilities of three botanical supplements, &lt;em&gt;Hypericum perforatum&lt;/em&gt; L. (HPL), &lt;em&gt;Herba Verbena Officinalis&lt;/em&gt; (HVO), and &lt;em&gt;Valeriana officinalis&lt;/em&gt; L. (VO), which have been reported to effectively treat menopause symptoms. &lt;strong&gt;Methods:&lt;/strong&gt; The antioxidant activities of the three supplements were determined by the ferric reducing ability of plasma (FRAP) assay. In addition, their free radical scavenging abilities were studied by ftheir interactions with the stable radicals of 2, 2&amp;rsquo;-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH). &lt;strong&gt;Results:&lt;/strong&gt; The results indicated that the HPL ethanolic extract exhibited greater antioxidant activity (1.2688 &amp;plusmn; 0.01 mmol Trolox/g) than the HVO ethanolic extract (1.1686&amp;plusmn; 0.043 mmol Trolox/g) and the VO ethanolic extract (0.2579 &amp;plusmn; 0.0031 mmol Trolox/g) as compared to Nilestriol (0.0026&amp;plusmn;0.0012), a positive control agent in the experiment. Moreover, the HPL extract showed remarkable free radical scavenging activity against ABTS&lt;strong&gt;&amp;bull;&lt;/strong&gt;+, and the HVO extract was the most potent against DPPH&lt;strong&gt;&amp;bull;&lt;/strong&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These activities may be attributed to the total flavonoid or phenolic acid contents of among these extracts.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">198</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Yi-ming Li&lt;sup&gt;1&lt;/sup&gt;, Yan-Ru Liu&lt;sup&gt;2,3&lt;/sup&gt;, Bing-Kun Xiao&lt;sup&gt;2&lt;/sup&gt;, Jian-Yun Yang&lt;sup&gt;2&lt;/sup&gt;, Rong-Qing Huang&lt;sup&gt;2*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Anhui Medical University,Hefei 230032, P. R.China.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Beijing Institute of Radiation Medicine, Haidian District, Beijing 100850, P.R. China.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;The School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenhe District, Shenyang 110016, P.R. China.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author><author><style face="normal" font="default" size="100%">Mshelia Emmanuel Halilu</style></author><author><style face="normal" font="default" size="100%">Aliyu Muhammad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis and Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aqueous decoction of the stem back of Mangifera indica L. has been traditionally used for the treatment of various illnesses among them includes anaemia. Aims: The aim of this study was to investigate the anti-anaemic properties of standardized stem bark extract of M. indica in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An in vivo animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed and to ascertain the level of haemolysis. GC-MS was used determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed presence of 15 compounds viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of Mangefera indica L. This finding highlights the potentials of the extract and M. indica in the treatment of haemolytic anaemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;1*&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in Wister rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Dec, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The aqueous decoction of the stem back of&lt;em&gt; Mangifera indica&lt;/em&gt; L. has been traditionally used for the treatment of various illnesses among them includes anaemia.&lt;strong&gt; Aims: &lt;/strong&gt;The aim of this study was to investigate the anti-anaemic properties of the standardized stem bark extract of &lt;em&gt;M. indica&lt;/em&gt; in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An&lt;em&gt; in vivo&lt;/em&gt; animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed to determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration was increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt when while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed the presence of 15 compounds among viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of &lt;em&gt;Mangefera indica&lt;/em&gt; L. This finding highlights the potentials of the extract&lt;em&gt; M. indica&lt;/em&gt; in the treatment of haemolytic anaemia.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;2,4-dinitrophenylhydrazine, Anaemia, GC-MS analysis, Haemolysis &lt;em&gt;Mangifera indica&lt;/em&gt; L.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;*1&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haroon Khan</style></author><author><style face="normal" font="default" size="100%">Murad Ali Khan</style></author><author><style face="normal" font="default" size="100%">Abdul Rauf</style></author><author><style face="normal" font="default" size="100%">Ashhad Haleemi</style></author><author><style face="normal" font="default" size="100%">Shivkanya Fuloria</style></author><author><style face="normal" font="default" size="100%">Neeraj Kumar Fuloria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition on Urease and Thermal Induced Protein Denaturation of commonly used Antiulcer Herbal Products. Study based on in-vitro assays</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Akseer ULCER</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiurease activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Endemali</style></keyword><keyword><style  face="normal" font="default" size="100%">in-vitro assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal induced protein denaturation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">147-151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;In-vitro&lt;/em&gt; urease inhibitory and thermal induced protein denaturation inhibitory activities was performed for two commonly used herbal products Endemali and Akseer ULCER in the treatment of ulcers. &lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the antiulcer potential of two commonly used herbal products, Endemali, Akseer ULCER. &lt;strong&gt;Material and Method:&lt;/strong&gt; In urease inhibitory assay, enzyme solution, extract, diferent regaents added and absorbance was measured at 630 nm (50 min, pH 8.2) and thiourea used as standard. In protein denaturation assay, the egg albumin was mixed with different concentration of test compounds, buffer absorbance was measured. Aspirin was used as standard. &lt;strong&gt;Results:&lt;/strong&gt; The Endemali had a profound effect on the urease activity in a concentration dependent manner with EC50value of 0.468 mg/ml. The Akseer ULCER antagonized the urease activity markedly with EC&lt;sub&gt;50&lt;/sub&gt; value of 0.374 mg/ml. These tested herbal products caused marked inhibition of thermal induced protein denaturation in a concentration dependent manner. The potency in the form of EC&lt;sub&gt;50&lt;/sub&gt; for Endemali, Akseer ULCER was measured as 323, 337 &amp;mu;g/ml respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; In short, the tested herbal drug showed strong inhibition on urease activity and inhibition on thermal induced protein denaturation thus our study validated their uses in the treatment of ulcers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">147</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Haroon Khan&lt;sup&gt;*1&lt;/sup&gt;, Murad Ali Khan&lt;sup&gt;2&lt;/sup&gt;, Abdul Rauf&lt;sup&gt;3&lt;/sup&gt;, Ashhad Haleemi&lt;sup&gt;4&lt;/sup&gt;, Shivkanya Fuloria&lt;sup&gt;5&lt;/sup&gt;, Neeraj Kumar Fuloria&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, University of Peshawar, Peshawar-25120, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmcy, AIMST University,Semeling Campus, Bedong, Kedah Darul Aman-08100, Malyasia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haroon Khan</style></author><author><style face="normal" font="default" size="100%">Murad Ali Khan</style></author><author><style face="normal" font="default" size="100%">Abdul Rauf</style></author><author><style face="normal" font="default" size="100%">Ashhad Haleemi</style></author><author><style face="normal" font="default" size="100%">Shivkanya Fuloria</style></author><author><style face="normal" font="default" size="100%">Neeraj Kumar Fuloria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition on Urease and Thermal Induced Protein Denaturation of commonly used Antiulcer Herbal Products. Study based on in-vitro assays</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Akseer ULCER</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiurease activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Endemali</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal induced protein denaturation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">16th Jan, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">147-151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;In-vitro&lt;/em&gt; urease inhibitory and thermal induced protein denaturation inhibitory activitieswasperformed for two commonly used herbal productsEndemali and Akseer ULCER in the treatment of ulcers.&lt;strong&gt;Objectives: &lt;/strong&gt;to evaluate the antiulcer potential of two commonly used herbal products, Endemali, Akseer ULCER. &lt;strong&gt;Material and Method:&lt;/strong&gt; In urease inhibitory assay , enzyme solution, extract, diferentregaents added and absorbance was measured at 630 nm (50 min, pH 8.2) and thiourea used as standard. In protein denaturation assay the egg albumin was mixed with different concentration of test compounds, buffer absorbance was measured. Aspirin was used as standard. &lt;strong&gt;Results:&lt;/strong&gt; The Endemalihad a profound effect on the urease activity in a concentration dependent manner with EC&lt;sub&gt;50&lt;/sub&gt; valueof 0.468 mg/ml. The Akseer ULCER antagonized the urease activity markedly with EC&lt;sub&gt;50 &lt;/sub&gt;value of 0.374 mg/ml.These tested herbal products caused marked inhibition of thermal induced protein denaturation in a concentration dependent manner. The potency in the form of EC&lt;sub&gt;50 &lt;/sub&gt;for Endemali, Akseer ULCER was measured as 323, 337 &amp;micro;g/mlrespectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; In short, the tested herbal drug showed strong inhibition on urease activity and inhibition on thermal induced protein denaturation thus our study validated their uses in the treatment of ulcers.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Akseer ULCER, Endemali, Antiurease activity, Thermal induced protein denaturation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">147</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Haroon Khan&lt;sup&gt;*1&lt;/sup&gt;, Murad Ali Khan&lt;sup&gt;2&lt;/sup&gt;, Abdul Rauf&lt;sup&gt;3&lt;/sup&gt;, Ashhad Haleemi&lt;sup&gt;4&lt;/sup&gt;, Shivkanya Fuloria&lt;sup&gt;5&lt;/sup&gt;, Neeraj Kumar Fuloria&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Chemical Sciences, University of Peshawar, Peshawar -25120, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, University of Peshawar, Peshawar -25120, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmcy, AIMST University,Semeling Campus, Bedong, Kedah Darul Aman-08100, Malyasia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ehouman Evans</style></author><author><style face="normal" font="default" size="100%">Koné Mamidou Witabouna</style></author><author><style face="normal" font="default" size="100%">Tra Bi Fézan Honora</style></author><author><style face="normal" font="default" size="100%">Bakayoko Adama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Iron Reducing and Radical Scavenging Activities of 13 Medicinal Plants From Côte d’Ivoire</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Côte d’Ivoire</style></keyword><keyword><style  face="normal" font="default" size="100%">FRAP</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron.</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">266-270</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Oxidative stress has been involved in the development of varied human diseases. The aim of this study was to evaluate the iron reducing power and the antiradical activity of 13 plants traditionally used as medicinal plants in C&amp;ocirc;te d&amp;rsquo;Ivoire. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; FRAP (ferric reducing antioxidant power) and ABTS (2,2&amp;rsquo;-azino-bis(3-ethylbenzothiazoline- 6-sulfonic acid)) assays were used to assess the antioxidant property of 80% methanol extracts prepared from the 13 plants.&lt;strong&gt; Results:&lt;/strong&gt; A high iron reducing activity was exhibited by extracts from leaves of &lt;em&gt;Leea guineensis&lt;/em&gt; (42.76 &amp;plusmn; 28.54 mg of TE/gdry extract) and &lt;em&gt;Bersama abyssinica&lt;/em&gt; (39.77 &amp;plusmn; 31.29 mg of TE/g dry extract). &lt;em&gt;Smeathmannia pubescens&lt;/em&gt; (% ABTS = 92.44 &amp;plusmn; 12.93%), &lt;em&gt;L. guineensis&lt;/em&gt; (%ABTS = 89.73 &amp;plusmn; 15.10%), &lt;em&gt;Keetia venosa&lt;/em&gt; (% ABTS = 88.78 &amp;plusmn; 17.36 %) and &lt;em&gt;Sapium ellipticum&lt;/em&gt; (%ABTS = 85.86 &amp;plusmn; 25.10%), showed promising antiradical activity with IC&lt;sub&gt;50&lt;/sub&gt; values of 4.50, 5.00, 5.40 and 5.70 &amp;mu;g/mL respectively. These values are (p &amp;lt; 0.05) close to those of Trolox (CI&lt;sub&gt;50&lt;/sub&gt; = 4.10 &amp;mu;g/mL) and ascorbic acid (CI&lt;sub&gt;50&lt;/sub&gt; = 4.90 &amp;mu;g/mL). &lt;strong&gt;Conclusion: &lt;/strong&gt;Our findings confirm the traditional use of the studied plants in treatment of various ailments. The results obtained provide promising baseline information for using these medicinal plants for improving the health status of the population.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">266</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ehouman Evans&lt;sup&gt;1&lt;/sup&gt;, Kon&amp;eacute; Mamidou Witabouna&lt;sup&gt;1,2,*&lt;/sup&gt;, Tra Bi F&amp;eacute;zan Honora&lt;sup&gt;1&lt;/sup&gt; and Bakayoko Adama&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;UFR Sciences de la Nature, Universit&amp;eacute; Nangui Abrogoua, BP 801 Abidjan 02, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Centre Suisse de Recherches Scientifiques en C&amp;ocirc;te d&amp;rsquo;Ivoire, BP 1303 Abidjan 01, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ehouman Evans</style></author><author><style face="normal" font="default" size="100%">Koné Mamidou Witabouna</style></author><author><style face="normal" font="default" size="100%">Bakayoko Adama</style></author><author><style face="normal" font="default" size="100%">Tra Bi Fézan Honora</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Iron Reducing and Radical Scavenging Activities of 13 Medicinal Plants From Côte d’Ivoire</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">29th Apr, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">204-211</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Oxidative stress has been involved in the development of varied human diseases. The aim of this study was to evaluate the iron reducing power and the antiradical activity of 13 plants traditionally used as medicinal plants in C&amp;ocirc;te d&amp;rsquo;Ivoire. FRAP (ferric reducing antioxidant power) and ABTS (2,2&amp;rsquo;-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) assays were used to assess the antioxidant property of 80 % methanol extracts prepared from the 13 plants. A high iron reducing activity was exhibited by extracts from leaves of Leea guineensis (42.76 &amp;plusmn; 28.54 mg of TE/gdry extract) and Bersama abyssinica (39.77 &amp;plusmn; 31.29 mg of TE/g dry extract). Smeathmannia pubescens (% ABTS = 92.44 &amp;plusmn; 12.93 %), L. guineensis (%ABTS = 89.73 &amp;plusmn; 15.10 %), Keetia venosa (% ABTS = 88.78 &amp;plusmn; 17.36 %) and Sapium ellipticum (% ABTS = 85.86 &amp;plusmn; 25.10 %), showed promising antiradical activity with IC50 values of 4.50, 5.00, 5.40 and 5.70 &amp;micro;g/mL respectively. These values are (p&amp;lt; 0.05) close to those of Trolox (CI50 = 4.10 &amp;micro;g/mL) and ascorbic acid (CI50 = 4.90 &amp;micro;g/mL). Our findings confirm the traditional use of the studied plants in treatment of various ailments. The results obtained provide promising baseline information for using these medicinal plants for improving the health status of the population.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;ABTS, Antioxidants, C&amp;ocirc;te d&amp;rsquo;Ivoire, FRAP, Medicinal plants&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ehouman Evans&lt;sup&gt;a&lt;/sup&gt;, Kon&amp;eacute; Mamidou Witabouna&lt;sup&gt;a,b,*&lt;/sup&gt;, Bakayoko Adamaa,&lt;sup&gt;b&lt;/sup&gt; and Tra Bi F&amp;eacute;zan Honora&lt;sup&gt;a &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department UFR Sciences de la Nature, Universit&amp;eacute; Nangui Abrogoua, BP 801 Abidjan 02, C&amp;ocirc;te d&amp;#39;Ivoire, AFRICA.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Department Centre Suisse de Recherches Scientifiques en C&amp;ocirc;te d&amp;rsquo;Ivoire, BP 1303 Abidjan 01, C&amp;ocirc;te d&amp;#39;Ivoire, AFRICA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Md. Azizur Rahman</style></author><author><style face="normal" font="default" size="100%">Arshad Hussain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and analytical evaluation of Cordia dichotoma Linn. leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cordia dichotoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC chromatogram.</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameters</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">58-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; An ethnomedicinally important plant, &lt;em&gt;Cordia dichotoma&lt;/em&gt; Linn is practiced in various indigenous systems of medicine and popular among the various ethnic groups in India for the cure of variety of ailments as an astringent, anthelmentic, diuretic, demulcent, anti-diabetic and expectorant. Because of the increasing demand, maintaining quality standards is the need of the day. &lt;strong&gt;Aims and Objectives:&lt;/strong&gt; The present study was designed to set standard pharmacognostical, physicochemical, phytochemical, fluorescence and HPTLC chromatographic profile of the leaves of &lt;em&gt;Cordia dichotoma &lt;/em&gt;Linn (CD). &lt;strong&gt;Materials and Methods: &lt;/strong&gt;CD, which was previously authenticated, was subjected to pharmacognostical, physicochemical, fluorescence and high performance thin-layer chromatography (HPTLC) analysis as per standard protocol. &lt;strong&gt;Results and Conclusion:&lt;/strong&gt; The final observations were recorded. The loss on drying at 105&amp;ordm;C was found to be 8.5% w/w, total ash value 13% w/w, acid-insoluble ash 5.07% w/w, water-soluble ash 5.49% w/w, water-soluble extractive 9.2% w/w, alcohol-soluble extractive 5.81% w/w and pH (1% aqueous extract) 6.88. Phytochemical screening showed the presence of steroid, carbohydrate, alkaloid, saponin, cardiac glycosides, flavonoid and phenolic compounds in methanolic extract. The CD fluorescence was seen in UV light and it was of different colour in different solvents. HPTLC analysis revealed 5 peaks at wavelength 366 nm with max R&lt;sub&gt;f&lt;/sub&gt; values in the range of 0.3 to 0.93. The purity and quality of the leaves of &lt;em&gt;Cordia dichotoma&lt;/em&gt; or pharmaceutical preparations prepared from it can be tested by pharmacognostical, physicochemical, fluorescence and HPTLC observations of the present study.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Md. Azizur Rahman&lt;sup&gt;*&lt;/sup&gt;, Arshad Hussain&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;UP-CST Sponsored Project Lab, Faculty of Pharmacy, Integral University, Lucknow, U.P. (India) 226026.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Md Azizur Rahman</style></author><author><style face="normal" font="default" size="100%">Arshad Hussain</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and analytical evaluation of Cordia dichotoma Linn. leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cordia dichotoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Fluorescence analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC chromatogram.</style></keyword><keyword><style  face="normal" font="default" size="100%">Physicochemical parameters</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">58-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; An ethnomedicinally important plant, &lt;em&gt;Cordia dichotoma &lt;/em&gt;Linn is practiced in various indigenous systems of medicine and popular among the various ethnic groups in India for the cure of variety of ailments as an astringent, anthelmentic, diuretic, demulcent, anti-diabetic and expectorant. Because of the increasing demand, maintaining quality standards is the need of the day. &lt;strong&gt;Aims and Objectives:&lt;/strong&gt; The present study was designed to set standard pharmacognostical, physicochemical, phytochemical, fluorescence and HPTLC chromatographic profile of the leaves of &lt;em&gt;Cordia dichotoma&lt;/em&gt; Linn (CD). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; CD, which was previously authenticated, was subjected to pharmacognostical, physicochemical, fluorescence and high performance thin-layer chromatography (HPTLC) analysis as per standard protocol. &lt;strong&gt;Results and Conclusion: &lt;/strong&gt;The final observations were recorded. The loss on drying at 105&amp;ordm;C was found to be 8.5% w/w, total ash value 13% w/w, acid-insoluble ash 5.07% w/w, water-soluble ash 5.49% w/w, water-soluble extractive 9.2% w/w, alcohol-soluble extractive 5.81% w/w and pH (1% aqueous extract) 6.88. Phytochemical screening showed the presence of steroid, carbohydrate, alkaloid, saponin, cardiac glycosides, flavonoid and phenolic compounds in methanolic extract. The CD fluorescence was seen in UV light and it was of different colour in different solvents. HPTLC analysis revealed 5 peaks at wavelength 366 nm with max R&lt;sub&gt;f&lt;/sub&gt; values in the range of 0.3 to 0.93. The purity and quality of the leaves of &lt;em&gt;Cordia dichotoma&lt;/em&gt; or pharmaceutical preparations prepared from it can be tested by pharmacognostical, physicochemical, fluorescence and HPTLC observations of the present study..&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;&lt;em&gt;Cordia dichotoma&lt;/em&gt;, Fluorescence analysis, Physicochemical parameters, HPTLC chromatogram.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Md. Azizur Rahman, Arshad Hussain</style></custom1><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Md. Azizur Rahman&lt;sup&gt;*&lt;/sup&gt;, Arshad Hussain &lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;UP-CST Sponsored Project Lab, Faculty of Pharmacy, Integral University, Lucknow, U.P. (India) 226026&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amit Kumar Srivastava</style></author><author><style face="normal" font="default" size="100%">Srivastava Abhinav Siddharth</style></author><author><style face="normal" font="default" size="100%">Nagar Hemant</style></author><author><style face="normal" font="default" size="100%">Srivastava Rajnish</style></author><author><style face="normal" font="default" size="100%">Deepa</style></author><author><style face="normal" font="default" size="100%">Shukla Gaurav</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholine</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitussive</style></keyword><keyword><style  face="normal" font="default" size="100%">Bronchoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Citric acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough variant asthma (CVA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF)</style></keyword><keyword><style  face="normal" font="default" size="100%">Histamine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th June 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">5-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the pharmacological potential of ethanolic extract of &lt;em&gt;Woodfordia fruticosa&lt;/em&gt; (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. &lt;strong&gt;Material and Method:&lt;/strong&gt; Antitussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1% histamine and 2% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA.&lt;strong&gt; Results:&lt;/strong&gt; EEWF at aerosolic dose of 6% w/v exhibit decrease in of the average coughs frequency (4.83&amp;plusmn;0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75% and decreases number of coughs (7.16&amp;plusmn;0.47) at 200 mg/kg as compared to control (14.16&amp;plusmn;0.60). &lt;strong&gt;Conclusion:&lt;/strong&gt; EEWF at 200 mg/kg dose exhibited bronchoprotective and antitussive effects against aerosol induced CVA.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt; Acetylcholine, Antitussive, Bronchoprotection, Citric acid, Cough, Cough variant asthma (CVA), Ethanolic extract of &lt;em&gt;Woodfordia fruticosa&lt;/em&gt; (L.) Kurz (EEWF), Histamine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Amit Kumar Srivastava&lt;sup&gt;*1&lt;/sup&gt;, Srivastava Abhinav Siddharth&lt;sup&gt;2&lt;/sup&gt;, Nagar Hemant&lt;sup&gt;2&lt;/sup&gt;, Srivastava Rajnish&lt;sup&gt;3&lt;/sup&gt;, Deepa&lt;sup&gt;4&lt;/sup&gt; and Shukla Gaurav&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology Sapience Bio-analytical Research Lab. Indrapuri, Bhopal (M.P.) India.&lt;br /&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Truba Institute of Pharmacy, Karond, Gandhi Nagar Bypass Road, Bhopal (M.P.) India.&lt;br /&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Moradabad Educational Trust, Ram Ganga vihar, Civil lines, Moradabad (U.P.) India.&lt;br /&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, NRI Institute of Pharmaceutical Sciences, SajjanSingh Nagar, Raisen Road, Bhopal (M.P.) India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amit Kumar Srivastava</style></author><author><style face="normal" font="default" size="100%">Srivastava Abhinav Siddharth</style></author><author><style face="normal" font="default" size="100%">Nagar Hemant</style></author><author><style face="normal" font="default" size="100%">Srivastava Rajnish</style></author><author><style face="normal" font="default" size="100%">Deepa</style></author><author><style face="normal" font="default" size="100%">Shukla Gaurav</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acetylcholine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tussive</style></keyword><keyword><style  face="normal" font="default" size="100%">Bronchoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Citric acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough</style></keyword><keyword><style  face="normal" font="default" size="100%">Cough variant asthma (CVA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF)</style></keyword><keyword><style  face="normal" font="default" size="100%">Histamine.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">296-299</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the pharmacological potential of ethanolic extract of &lt;em&gt;Woodfordia fruticosa&lt;/em&gt; (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. &lt;strong&gt;Material and Method:&lt;/strong&gt; Anti-tussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1% histamine and 2% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. &lt;strong&gt;Results:&lt;/strong&gt; EEWF at aerosolic dose of 6% w/v exhibit decrease in of the average coughs frequency (4.83 &amp;plusmn; 0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75% and decreases number of coughs (7.16 &amp;plusmn; 0.47) at 200 mg/kg as compared to control (14.16 &amp;plusmn; 0.60). &lt;strong&gt;Conclusion:&lt;/strong&gt; EEWF at 200 mg/kg dose exhibited bronchoprotective and anti-tussive effects against aerosol induced CVA.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Amit Kumar Srivastava&lt;sup&gt;*1&lt;/sup&gt;, Srivastava Abhinav Siddharth&lt;sup&gt;2&lt;/sup&gt;, Nagar Hemant&lt;sup&gt;2&lt;/sup&gt;, Srivastava Rajnish&lt;sup&gt;3&lt;/sup&gt;, Deepa&lt;sup&gt;4&lt;/sup&gt; and Shukla Gaurav&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology Sapience Bio-analytical Research Lab. Indrapuri, Bhopal (M.P.) India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Truba Institute of Pharmacy, Karond, Gandhi Nagar Bypass Road, Bhopal (M.P.) India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Moradabad Educational Trust, Ram Ganga vihar, Civil lines, Moradabad (U.P.) India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, NRI Institute of Pharmaceutical Sciences, SajjanSingh Nagar, Raisen Road, Bhopal (M.P.) India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kamal Hasan</style></author><author><style face="normal" font="default" size="100%">Thangavelu Lakshmi</style></author><author><style face="normal" font="default" size="100%">Thirumalai Kumaran Rathinam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Phytochemical Analysis and In vitro Anti-helmenthic activity of Achyranthes aspera Leaf extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achyranthes aspera</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-helmenthic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Laxative</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">397-399</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the preliminary phytochemical analysis and &lt;em&gt;in vitro&lt;/em&gt;- Antihelmenthic activity of leaf extract of &lt;em&gt;Achyranthes aspera&lt;/em&gt;.&lt;strong&gt; Background:&lt;/strong&gt; &lt;em&gt;Achyranthes aspera &lt;/em&gt;is an annual, stiff-erect herb found commonly as a weed throughout India. The leaf ethyl acetate extract showed high larvicidal activity on the tick larvae of Rhipicephalus. It strengthen the liver and kidneys, strengthening muscles, tendons and bones, anti-inflammatory, anti-toxin, urine laxative, normalize menstruation, hemostatic, ease childbirth. Chemical Ingredients includes Akirantin, glokosa, galactose, reilosa, ramnosa, and alkaloids. Hentriakontan, sapogenin, Betaine, ecdysterone, triterpenoid saponins. &lt;strong&gt;Methods:&lt;/strong&gt; Preliminary phytochemical analysis was done by adopting the method of Evans. Antihelmenthic assay is performed by standard protocol. &lt;strong&gt;Result:&lt;/strong&gt; The present study reveals the presence of few secondary metabolites and the extract exhibitspotent Antihelmenthic activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the present study it can be concluded that &lt;em&gt;Achyranthes aspera&lt;/em&gt; leaf extract possessed marked &lt;em&gt;in vitro&lt;/em&gt; Anti helminthic effect.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">397</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kamal Hasan&lt;sup&gt;1&lt;/sup&gt;, Thangavelu Lakshmi&lt;sup&gt;2*&lt;/sup&gt; and Thirumalai Kumaran Rathinam&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Bachelor of Dental Surgery, Saveetha Dental College, Saveetha University, Chennai, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacognosy, Sree ramachandra University, Chennai, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deepali Pandey</style></author><author><style face="normal" font="default" size="100%">Apurva Joshi</style></author><author><style face="normal" font="default" size="100%">S. Hemalatha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quality Control Standardization and In-Vitro Antioxidant Activity of Aganosma dichotoma K. Schum Root</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">74-82</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Aganosma dichotoma&lt;/em&gt; K. Schum (AD) is a large climber with very stout stem belonging to the family &lt;em&gt;Apocynaceae&lt;/em&gt;. The Plant has significant medicinal value as described in traditional system of medicine. The objective of the present study is to scientifically develop a standard monograph for AD on the basis of its pharmacognostical and phytochemical aspects.&lt;strong&gt; Methods:&lt;/strong&gt; The study includes quality control standardization as per the standard methods provided in World Health Organization for standardization of medicinal plants. Fluorescence drug analysis, preliminary phytochemical screening of different fractions, quantification of some phytoconstituents and &lt;em&gt;in-vitro&lt;/em&gt; antioxidant activity were also carried out. Quantification of Quercetin in the ethanolic extract of&lt;em&gt; A. dichotoma&lt;/em&gt; was determined by HPTLC analysis. The ethanolic extract of root of &lt;em&gt;A. dichotoma&lt;/em&gt; was subjected to &lt;em&gt;in-vitro&lt;/em&gt; antioxidant activity. &lt;strong&gt;Results:&lt;/strong&gt; The diagnostic characters of &lt;em&gt;A. dichotoma&lt;/em&gt; root were evaluated on the basis of macroscopical and microscopical characters. Physicochemical parameters were evaluated such as 6.7% w/w loss on drying with; ash values (in % w/w): 13.75 total ash, 5.75 acid-insoluble ash, 3.6 water-soluble ash; Extractive values (% w/w): 12.75 water, 11.82 ethanol, 2.26 ethyl acetate, 3.13 chloroform, and 3.16 pet ether; foaming index 181.81; swelling index 3.2 ml/g; hemolytic activity 227.89 unit/gm of powder drug and crude fiber content was 19.4%. Total numbers of starch grain in 1 mg of root powder were 2,49,981. Quantification of quercetin in the ethanolic extract was assessed by HPTLC analysis and was found to contain 2.40%, w/w. &lt;strong&gt;Conclusion:&lt;/strong&gt; The parameters determined in the present study may provide necessary information for identification and authentication of plant material.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">74</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Deepali Pandey, Apurva Joshi, S. Hemalatha&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi (U.P.)221005, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Deepali Pandey</style></author><author><style face="normal" font="default" size="100%">Apurva Joshi,</style></author><author><style face="normal" font="default" size="100%">Hemalatha, S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quality Control Standardization and In-Vitro Antioxidant Activity of Aganosma dichotoma K. Schum Root</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aganosma dichotoma</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">in-vitro antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Nov, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">74-82</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Aganosma dichotoma&lt;/em&gt; K. Schum (AD) is a large climber with very stout stem belonging to the family Apocynaceae. The Plant has significant medicinal value as described in traditional system of medicine. The objective of the present study is to scientifically develop a standard monograph for AD on the basis of its pharmacognostical and phytochemical aspects. &lt;strong&gt;Methods:&lt;/strong&gt; The study includes quality control standardization as per the standard methods provided in World Health Organization for standardization of medicinal plants. Fluorescence drug analysis, preliminary phytochemical screening of different fractions, quantification of some phytoconstituents and&lt;em&gt; in-vitro &lt;/em&gt;antioxidant activity were also carried out. Quantification of Quercetin in the ethanolic extract of&lt;em&gt; A. dichotoma &lt;/em&gt;was determined by HPTLC analysis. The ethanolic extract of root of&lt;em&gt; A.&lt;/em&gt;&lt;em&gt;dichotoma &lt;/em&gt;was subjected to&lt;em&gt; in-vitro &lt;/em&gt;antioxidant activity. &lt;strong&gt;Results:&lt;/strong&gt; The diagnostic characters of &lt;em&gt;A.dichotoma &lt;/em&gt;root were evaluated on the basis of macroscopical and microscopical characters. Physicochemical parameters were evaluated such as 6.7% w/w loss on drying with; ash values (in % w/w): 13.75 total ash, 5.75 acid-insoluble ash, 3.6 water-soluble ash; Extractive values (% w/w): 12.75 water, 11.82 ethanol, 2.26 ethyl acetate, 3.13 chloroform, and 3.16 pet ether; foaming index 181.81; swelling index 3.2 ml/g; hemolytic activity 227.89 unit/gm of powder drug and crude fiber content was 19.4%. Total numbers of starch grain in 1 mg of root powder were 2,49,981. Quantification of quercetin in the ethanolic extract was assessed by HPTLC analysis and was found to contain 2.40%, w/w. &lt;strong&gt;Conclusion: &lt;/strong&gt;The parameters determined in the present study may provide necessary information for identification and authentication of plant material.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Aganosma dichotoma&lt;/em&gt;, HPTLC,&lt;em&gt; in-vitro&lt;/em&gt; antioxidant activity, Pharmacognosy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><custom1><style face="normal" font="default" size="100%">Deepali Pandey, Apurva Joshi, S. Hemalatha</style></custom1><section><style face="normal" font="default" size="100%">74</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Deepali Pandey, Apurva Joshi, S. Hemalatha&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Applied Nutrition Division, Defence Food Research Laboratory (DRDO), Ministry of Defence, India&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Weifang Long</style></author><author><style face="normal" font="default" size="100%">Qi Ding</style></author><author><style face="normal" font="default" size="100%">Yujie Chen</style></author><author><style face="normal" font="default" size="100%">Jiqing Hu</style></author><author><style face="normal" font="default" size="100%">Luyang Li</style></author><author><style face="normal" font="default" size="100%">Fei Zhang</style></author><author><style face="normal" font="default" size="100%">Dingrong Wan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantitative Determination and Variation Tendencies of Flavonoids in Five Selaginella Plant Drugs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Amentoflavone content</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Selaginella</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoids content</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-Vis spectrophotometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Variation tendencies</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">378-382</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Weifang Long&lt;sup&gt;1&lt;/sup&gt;, Qi Ding&lt;sup&gt;1&lt;/sup&gt;, Yujie Chen&lt;sup&gt;2&lt;/sup&gt;, Jiqing Hu&lt;sup&gt;1&lt;/sup&gt;, Luyang Li&lt;sup&gt;1&lt;/sup&gt;, Fei Zhang&lt;sup&gt;1&lt;/sup&gt; and Dingrong Wan&lt;sup&gt;1,3*&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, College of Pharmacy, South-Central University for Nationalities, Wuhan, China. &lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Hainan Provincial Key Laboratory of R &amp;amp; D of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, China. 3The Modernization Engineering Technology Research Center of Ethnic Minority Medicine of Hubei Province, China.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shazia Usmani</style></author><author><style face="normal" font="default" size="100%">Arshad Hussain</style></author><author><style face="normal" font="default" size="100%">A.H.A Farooqui</style></author><author><style face="normal" font="default" size="100%">Mohd.Arshad</style></author><author><style face="normal" font="default" size="100%">Sahabjada Siddiqui</style></author><author><style face="normal" font="default" size="100%">Mohd.Ahmad</style></author><author><style face="normal" font="default" size="100%">Shadma Wahab</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiproliferative activity of crude extract and fractions obtained from Digera muricata on Hela cell lines of human cervix and A549 cell lines of Human Lung.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-(4</style></keyword><keyword><style  face="normal" font="default" size="100%">4 diphenyltetrazolium bromide assay</style></keyword><keyword><style  face="normal" font="default" size="100%">5-dimethylthiazol-2yl)-2</style></keyword><keyword><style  face="normal" font="default" size="100%">A549 Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Digera muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">32-38</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Digera muricata&lt;/em&gt; (Linn.) of family Amaranthaceae is an ethanobotanically important plant species traditionally used against various disorders. Cytotoxic potential of methanolic extract and its fractions were investigated against Hela and A&lt;sub&gt;549&lt;/sub&gt; cell lines. Crude extract of Digera muricata was prepared in methanol by Continuous Hot Soxhlation technique. Crude extract was fractionated into two organic and one aqueous fraction by the help of Column Chromatography. MTT assay was used to evaluate the reduction of viability of the cancer cell lines. Cell viability was inhibited by crude extract of &lt;em&gt;Digera muricata&lt;/em&gt; in a dose dependent manner ranging from 25&amp;mu;g/ml to 250&amp;mu;g/ml. Apoptosis assays using nucleic acid stains namely PI exclusion assay and Hoestch/PI assay were performed by the help of fluorescence microscopy. Morphological analysis was done by calculation of Apoptotic ratio and Percentage apoptosis. Our results suggests that methanolic and aqueous fraction of the extract of &lt;em&gt;Digera muricata&lt;/em&gt; can be good source of cytotoxic compounds.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; 3-(4,5-dimethylthiazol-2yl)-2,4 diphenyltetrazolium bromide assay, A&lt;sub&gt;549&lt;/sub&gt; cell line, cytotoxic,
Digera muricata, HeLa cell line.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Shazia Usmani&lt;sup&gt;a*&lt;/sup&gt;&lt;sub&gt;, &lt;/sub&gt;Arshad Hussain&lt;sup&gt;a&lt;/sup&gt;, A.H.A Farooqui&lt;sup&gt;b&lt;/sup&gt;, Mohd.Arshad&lt;sup&gt;c&lt;/sup&gt;, Sahabjada Siddiqui&lt;sup&gt;c&lt;/sup&gt;, Mohd.Ahmad&lt;sup&gt;a&lt;/sup&gt;, Shadma Wahab&lt;sup&gt;a&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;a&lt;/sup&gt;Faculty of Pharmacy, Integral University, Kursi Road, Lucknow-226026, INDIA.&lt;/p&gt;&lt;p&gt;&lt;sup&gt;b&lt;/sup&gt;Faculty of Biosciences, Integral University, Kursi Road, Lucknow-226026, INDIA.&lt;/p&gt;&lt;p&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Zoology, Faculty of Life Sciences, Lucknow University, Lucknow, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Natesh Prabhu</style></author><author><style face="normal" font="default" size="100%">Sanjay Hadigal</style></author><author><style face="normal" font="default" size="100%">Ullal sheetal D</style></author><author><style face="normal" font="default" size="100%">Sushma DS</style></author><author><style face="normal" font="default" size="100%">Ashok Shenoy K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Tribulus Terrestris on Learning And Memory in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hebb William Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Learning</style></keyword><keyword><style  face="normal" font="default" size="100%">Memory</style></keyword><keyword><style  face="normal" font="default" size="100%">T Maze</style></keyword><keyword><style  face="normal" font="default" size="100%">Tribulus terrestris</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">68-71</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The present study was designed to evaluate the effect of aqueous extract of fruits of &lt;em&gt;Tribulus terrestri&lt;/em&gt;s on learning and memory in rodents. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received &lt;em&gt;Tribulus terrestris&lt;/em&gt; orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. &lt;strong&gt;Results:&lt;/strong&gt; Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p&amp;lt;0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p&amp;lt;0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group.&lt;strong&gt; Conclusion: &lt;/strong&gt;The aqueous extract of fruits of &lt;em&gt;Tribulus terrestris&lt;/em&gt; showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Hebb William Maze, Learning, Memory, T Maze, &lt;em&gt;Tribulus terrestris&lt;/em&gt;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Natesh Prabhu, Sanjay Hadigal, Ullal Sheetal D&lt;sup&gt;*&lt;/sup&gt;, Sushma DS and Ashok Shenoy K&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Kasturba Medical College, Light House Hill Road, Mangalore-575001, Manipal University, Manipal, Karnataka, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manish Kumar,</style></author><author><style face="normal" font="default" size="100%">Satyendra K. Prasad,</style></author><author><style face="normal" font="default" size="100%">Damiki Laloo,</style></author><author><style face="normal" font="default" size="100%">Apurva Joshi,</style></author><author><style face="normal" font="default" size="100%">Siva Hemalatha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical and phytochemical standardization of Houttuynia cordata Thunb.: A potent medicinal herb of North–Eastern India and China</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Houttuynia cordata</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Quercetin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">34-42</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt;&lt;em&gt;Houttuynia cordata&lt;/em&gt; Thunb. (Saururaceae) is one of the perennial herb indigenous to North-East India and China. Despite the popular utilization of this herb as medicine, still no study has been reported so far regarding the pharmacognostical standardization. Thus, the aim of the present study was to scientifically establish a standard monograph on the basis of pharmacognostical and phytochemical aspects. &lt;strong&gt;Methods:&lt;/strong&gt; The quality control standardization of&lt;em&gt; H. cordata&lt;/em&gt; was done as per the methods described in the World Health Organization guidelines (2002). &lt;strong&gt;Results:&lt;/strong&gt; The diagnostic characters of the &lt;em&gt;H. Cordata&lt;/em&gt; leaf and rhizome portion were evaluated based on the macroscopical and microscopical characters. Determination of various physicochemical parameters such as water soluble ash (1.12% w/w), acid insoluble ash (4.02% w/w), sulphated ash (3.15% w/w), alcohol soluble extractive (12.8% w/w), water soluble extractive (14.9% w/w), loss on drying (3.42% w/w) and crude fibres content (13.10% w/w) was ascertained. Heavy metal, microbial load, fluorescence drug analysis, and preliminary phytochemical screening of different fractions were also carried out. Total phenols (45.74 mg/g tannic acid equivalent, TAE), tannins (33.29mg/g TAE), flavonoids (104.55 mg/g rutin equivalent, RE), and flavonols (17.16mg/g RE) were quantified from the ethanolic extract of the whole plant. Quantification of quercetin in the ethanolic extract was assessed by HPTLC analysis and was found to contain 4.39%, w/w. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained qualitative and quantitative standards will provide referential information for correct identification and standardization of this medicinal plant.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key Words: &lt;/strong&gt;&lt;em&gt;Houttuynia cordata&lt;/em&gt;, pharmacognosy, quercetin, HPTL.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Manish Kumar, Satyendra K. Prasad, Damiki Laloo, Apurva Joshi and Siva Hemalatha&lt;sup&gt;*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi&amp;ndash;221005, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Damiki Laloo,</style></author><author><style face="normal" font="default" size="100%">Satyendra K. Prasad,</style></author><author><style face="normal" font="default" size="100%">Manish Kumar,</style></author><author><style face="normal" font="default" size="100%">Siva Hemalatha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostical and phytochemical standardization of the roots of Potentilla mooniana Wight</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Heavy metals</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenolics</style></keyword><keyword><style  face="normal" font="default" size="100%">Potentilla mooniana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">70-79</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt;Potentilla mooniana&lt;/em&gt; Wight. (PM) (Family: Rosaceae) is a plant commonly grown at the higher altitudes (1500&amp;ndash;3660 meter) of the lower Asian continent and is traditionally used to treat gastric and mouth disorders. The present study was aimed to scientifically develop a standard monograph for PM on the basis of pharmacognostical and phytochemical aspects. &lt;strong&gt;Methods:&lt;/strong&gt; Pharmacognostically the roots were analyzed following the standard parameters prescribed under WHO guidelines and Indian Herbal Pharmacopoeia.&lt;strong&gt; Results:&lt;/strong&gt; Morphologically, the roots are cylindrical, dark brown and astringent to bitter in taste. Histologically, the root section showed the formation of secondary growth with wood formation and central lignified xylem vessels. Physicochemical standards quantified includes foreign organic matter (1.20% w/w), loss on drying (9.66% w/w), total ash (12.65% w/w), acid insoluble ash (4.65% w/w), water soluble ash (0.5% w/w), alcohol soluble extractive (21.3% w/w), water soluble extractive (14.6% w/w), foaming index (142.85), swelling index (6.5), haemolytic index (37.77). Quantification of pesticide residue content and heavy metals such as Pb, Cd, Zn and Hg was analyzed and were found to be present within the permissible limits. Powdered drug showed the presence of lignified xylem vessels with scalariform and spiral thickenings, tracheids, starch grains and fibres. Phytochemical screening showed the presence of phenolics, tannins, flavonoids, steroids, saponins, sugars, and amino acids. Quantification of phytoconstituents were also investigated such as phenolics (84.15mg/g tannic acid equivalent, TAE), tannins (65.31mg/g TAE), flavonoids (9.53mg/g rutin equivalent, RE), flavonols (2.01mg/g RE), saponins (20.75mg/g diosgenin equivalent, DE), sapogenins (15.4mg/g DE) and carbohydrates (56.8mg/g D&amp;ndash;fructose equivalent). TLC of the root extract was also analyzed in the present study.&lt;strong&gt; Conclusion:&lt;/strong&gt; In conclusion, the diagnostic characters obtained from the roots of &lt;em&gt;P. mooniana&lt;/em&gt; will provide beneficial information in identifying and comparing this plant from other closely related Potentilla species.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt;Potentilla mooniana&lt;/em&gt;, Pharmacognosy, phytochemical, polyphenolics, heavy metal.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Damiki Laloo, Satyendra K. Prasad, Manish Kumar and Siva Hemalatha&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi&amp;ndash;221 005, Uttar Pradesh, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiruthika Dhanraj</style></author><author><style face="normal" font="default" size="100%">Renuka Saravanan</style></author><author><style face="normal" font="default" size="100%">Sheik Abdulla Shahul Hameed</style></author><author><style face="normal" font="default" size="100%">Sivakumar Ramalingam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anticancer Potential of Vitus vinifera Seed Against Breast Cancer Cells - MDA-MB-231</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitus vinifera seed</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1064-1071</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present research is to evaluate the anti-cancer effect of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed on MDA-MB-231 cell line. &lt;strong&gt;Methods: &lt;/strong&gt;The &lt;em&gt;Vitus vinifera &lt;/em&gt;(Grape) seed were dried, powdered and subjected to methanol, chloroform and ethyl acetate extraction by cold maceration followed by preliminary phytochemical screening. The extracts of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed were subjected to assess anti-oxidant status, anti-proliferative activity by MTT assay, GC-MS analysis and apoptotic effect by determining LDH activity on MDA-MB-231. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that methanolic extract of grape seed showed appreciable anti-oxidant and anti-cancer potential compared with other two extracts. GC-MS mass spectrum of methanolic extract of seed revealed the presence of Dotriacontane, Linoleic acid and Decanoic acid ethyl ester, 1,2,3, propenetriol, monocetate, and Dichloro methyl propane sulfone were detected. &lt;strong&gt;Conclusion: &lt;/strong&gt;The data obtained in this work could be useful as a chemical standard in checking the genuineness of this plant source. Data of the results further depicted that the selected traditional &lt;em&gt;Vitus vinifera &lt;/em&gt;seed could be used not only as a potential anti-cancer and good antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiruthika Dhanraj, Renuka Saravanan, Sheik Abdulla Shahul Hameed, Sivakumar Ramalingam*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry and Biosciences, SASTRA Deemed to be University, Srinivasa Ramanujam Centre, Kumbakonam 612001, Tamil Nadu, INDIA.&lt;/p&gt;
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