<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hareg Zewdu Alehegn</style></author><author><style face="normal" font="default" size="100%">Abiodun A. Adeyemi</style></author><author><style face="normal" font="default" size="100%">Abayomi Mayowa Ajayi</style></author><author><style face="normal" font="default" size="100%">Foluke A. Fasola</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Phytochemical, Antioxidant, Anti-sickling, and Membrane Stabilization Properties of Justicia carnea Leaves and Stems Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Sickle Cell Disease</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">1-7</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Sickle cell disease (SCD) is an autosomal recessive inherited genetic blood disorder resulting from the aberrant structure of hemoglobin (Hb) that results in the production of hemoglobin S (Hb S). Objective: This study aimed to investigate the phytochemical profiles, antioxidant, anti-sickling, and membrane stabilizing activities of crude extracts of &lt;em&gt;Justicia carnea &lt;/em&gt;leaves and stems that used to treat SCD in Nigeria. &lt;strong&gt;Methods:&lt;/strong&gt; The 70 % ethanol crude extracts of the dried, powdered leaves and stems of &lt;em&gt;J. carnea&lt;/em&gt; were prepared by maceration. Reversal and inhibition activity of the plant materials were evaluated by using sodium-metabisulphite-sickled HB SS blood cells from two patients not in crisis. The membrane stabilization assays on rats' red blood cells (RBCs) and human sickled RBCs and antioxidant assays were determined following standard methods. Results were presented as Mean ± SEM. Data analysis and graph plotting were carried out using GraphPad Prism® version 8.01.&lt;strong&gt; Results:&lt;/strong&gt; The antioxidant assays indicated that &lt;em&gt;J. carnea&lt;/em&gt; leaves (JCL) had stronger DPPH activity (IC₅₀ = 245.031 ± 0.228 μg/mL). While, the stems (JCS) exhibited higher NO scavenging (84.123 ± 0.497 μg/mL). The highest reversal and inhibition percentages observed at 60, 90, and 120-minute time points. At 60th minutes reading, JCL 20 mg/mL (78.9±0.13%) demonstrated the highest reversal activity, while JCL 10 mg/mL (66.9±0.82 %) revealed the strongest inhibition effect. The extracts showed dose-dependent membrane stabilization activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The extracts demonstrated remarkable antioxidant, anti-sickling, and membrane stabilizing activities. The use of this plant could be a promising natural therapy for SCD.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hareg Zewdu Alehegn&lt;sup&gt;1,2*&lt;/sup&gt;, Abiodun A. Adeyemi&lt;sup&gt;3&lt;/sup&gt;, Abayomi Mayowa Ajayi&lt;sup&gt;4&lt;/sup&gt;, Foluke A. Fasola&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;M.Sc. Candidate, Medicinal Plants Research and Drug Development, Pan African University, Life and Earth Sciences Institute (Including Health and Agriculture), Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, ETHIOPIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Senior Lecturer, Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Senior Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, NIGERIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Reader/Consultant Haematologist Department of Haematology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarmad S. Salih. Al Qassar</style></author><author><style face="normal" font="default" size="100%">Rana Mahdi Fadhil</style></author><author><style face="normal" font="default" size="100%">Shahad A. Thanoon</style></author><author><style face="normal" font="default" size="100%">Gada A. Taqa</style></author><author><style face="normal" font="default" size="100%">Roaa Elias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Magnesium Oxide Against Orthodontically Induced Apical Root Resorption: An Experimental Rabbit Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cementum</style></keyword><keyword><style  face="normal" font="default" size="100%">Histomorphometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Magnesium oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Orthodontically induced root resorption</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodontal ligament</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">36-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Root resorption origin by orthodontic treatment (OIRR) is a frequent side effect. Thus, preservation of cementum and remodeling of the ligament (PDL) are critical in preventing such resorption. Magnesium (Mg2+) a mineral that have a dramatic role in mineralization, cell growth and regulating inflammation, however its function, in OIRR is not investigated. This study aimed to investigate the impacts of magnesium oxide (MgO) supplementation on apical root resorption, cementum and PDL. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Twenty adult male albino rabbits were randomly allocated into four groups (n = 5): negative control (no applied orthodontic force) positive control (orthodontic force applied only) low-dose MgO group (40 Mg2+/kg/day) and high-dose MgO group (80 Mg2+/kg/day). Orthodontic tooth displacement was initiated on the incisors through modified fixed orthodontic devices exerting a 40 g force over a period of three weeks. MgO was given orally once each day. Histomorphometric evaluation measured of cementoblasts, cementoclasts, fibroblasts and fibrocytes, the thickness of the cementum and PDL. Statistical analysis employed ANOVA followed by Tukey post hoc tests (&lt;em&gt;p&lt;/em&gt; ≤ 0.05). &lt;strong&gt;Results:&lt;/strong&gt; The positive control group exhibited cementum reduction, elevated cementoclast quantities diminished cementoblast levels and thinner PDL relative, to the negative control (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05). Both MgO-treated groups presented thicker cementum and PDL and fewer cementoclasts compared to the positive control with the high-dose group displaying the strongest protective impact. The number of fibroblasts significantly increased in the MgO groups. &lt;strong&gt;Conclusion:&lt;/strong&gt; MgO supplementation diminished OIRR with preserving cementum and PDL structure, suggested a potential protective role for magnesium during orthodontic treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">36</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sarmad S. Salih. Al Qassar&lt;sup&gt;1&lt;/sup&gt;, Rana Mahdi Fadhil&lt;sup&gt;2&lt;/sup&gt;, Shahad A. Thanoon&lt;sup&gt;3&lt;/sup&gt;, Gada A. Taqa&lt;sup&gt;4&lt;/sup&gt; and Roaa Elias&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pedo Ortho Prevention, College of Dentistry, University of Mosul, Mosul, Iraq. sarmadsobhi@uomosul.edu.iq; Orcid No. 0000- 0002-2758-761X.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer, Ministry of Health, Mosul, Iraq.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Lecturer, Department of Medical Instrumentation, Engineering Technology, Alnoor university, Mosul, Iraq.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Basic science, College of Dentistry, University of Mosul, Mosul, Iraq. 5Lecturer, Ministry of Health, Mosul, Iraq.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hugo Jesús Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Miriam Palomino- Pacheco</style></author><author><style face="normal" font="default" size="100%">Carlos Orlando Garcia-Bustamante</style></author><author><style face="normal" font="default" size="100%">Edwin Cesar Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Jessica Yolanda Huarcaya-Rojas</style></author><author><style face="normal" font="default" size="100%">Jaime David Torres-Lévano</style></author><author><style face="normal" font="default" size="100%">Julio Jose Pena-Galindo</style></author><author><style face="normal" font="default" size="100%">Esther Obdulia Franco-Soto</style></author><author><style face="normal" font="default" size="100%">Juana E. Chavez-Flores</style></author><author><style face="normal" font="default" size="100%">Robert Armando Cardenas-Orihuela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Neuroprotective Effects of Chuquiraga spinosa Less. and Baccharis genistelloides (Pers.) Lam. in a Rat Model of Transient Cerebral Ischemia-reperfusion</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cerebral ischemia; neuroprotection; antioxidants; Chuquiraga spinosa Less.; Baccharis genistelloides (Pers.) Lam</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">620-631</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cerebral ischemia, a leading cause of disability and mortality, is strongly related to oxidative stress and inflammation, highlighting the need for neuroprotective antioxidant and cytokinemodulating agents. &lt;strong&gt;Objective: &lt;/strong&gt;To characterize the phytochemical profile and evaluate the antioxidant and neuroprotective effects of hydroalcoholic extracts of&lt;em&gt; Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG), individually and in combination, in a rat model of cerebral ischemia–reperfusion. &lt;strong&gt;Methodology: &lt;/strong&gt;Phytochemical screening and GC-MS were performed with antioxidant assays (ABTS•⁺, DPPH•, FRAP). Neurological deficit was assessed (Bederson scale), while histopathology, oxidative stress markers (MDA, GSH, SOD, CAT, NOx), and cytokines (IL-6, TNF-α, IL-1β) were measured. Groups included Normal (no ischemia), Ischemia (oral placebo), Citicoline 300 mg/kg, ChS 500 mg/kg, BaG 500 mg/kg, and the oral combination ChS 500 + BaG 500 mg/kg, all administered for seven days prior to ischemia induction. &lt;strong&gt;Results: &lt;/strong&gt;ChS had higher total phenolic content than BaG (p = 0.0079). GC-MS identified 23 compounds in ChS and 17 in BaG. The combination displayed greater antioxidant activity than either extract. At 24 h, ChS 500 mg/Kg and the combination reduced severe neurological deficit to 17% (vs. 83% in ischemia). Histopathology revealed less neuronal damage with the combination, comparable to ChS 500 mg/Kg. All treatments decreased MDA levels; the combination also enhanced GSH and CAT and significantly reduced TNF-α and IL-1β. &lt;strong&gt;Conclusion:&lt;/strong&gt; ChS and BaG extracts exert neuroprotective effects against cerebral ischemia. Their combination shows synergistic antioxidant activity against free radicals and enhances the modulation of inflammatory cytokines, supporting a greater neuroprotective potential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">620</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hugo Jesús Justil-Guerrero&lt;sup&gt;1*&lt;/sup&gt;, Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Miriam Palomino- Pacheco&lt;sup&gt;2&lt;/sup&gt;, Carlos Orlando García-Bustamante&lt;sup&gt;1&lt;/sup&gt;, Edwin César Cieza-Macedo&lt;sup&gt;1&lt;/sup&gt;, Jessica Yolanda Huarcaya-Rojas&lt;sup&gt;3&lt;/sup&gt;, Jaime David Torres-Lévano&lt;sup&gt;3&lt;/sup&gt;, Julio José Peña-Galindo&lt;sup&gt;3&lt;/sup&gt;, Esther Obdulia Franco-Soto&lt;sup&gt;3&lt;/sup&gt;, Juana E. Chávez-Flores&lt;sup&gt;4&lt;/sup&gt;, Robert Armando Cárdenas-Orihuela&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos,Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biochemistry, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmacognosy, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Científica del Sur, Lima, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Academic Program of Pharmacy and Biochemistry, Universidad Norbert Wiener, Lima, PERÚ&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vivian Nathaly Echegaray Florian</style></author><author><style face="normal" font="default" size="100%">Claudia Giuliana Montoya Sisniegas</style></author><author><style face="normal" font="default" size="100%">Juan Ernesto Valdiviezo-Campos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Different Extraction Solvents on the Total Phenolic Content and Antioxidant Activity of Brassica oleracea var. italica</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Broccoli</style></keyword><keyword><style  face="normal" font="default" size="100%">Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Vegetable</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">58-62</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study offers an alternative solution for the prevention and/or treatment of diseases caused by free radicals. The objective was to evaluate the effect of different solvents on the total phenolic content and antioxidant activity of Brassica oleracea var. italica (broccoli). &lt;strong&gt;Methods: &lt;/strong&gt;The sample, consisting of stems and florets of Brassica oleracea var. italica (broccoli), were collected from the Chocas community in Carabayllo, Lima, Peru. Three extracts were prepared using different solvents, including a mixture of ethanol and water. The total phenolic content was determined using the Folin-Ciocalteu method, and antioxidant capacity was evaluated using two specific assays (DPPH and ABTS). Additionally, the correlation between total phenolic content and antioxidant activity was analyzed. &lt;strong&gt;Results:&lt;/strong&gt; The hydroethanolic extract demonstrated the highest phenolic content, with 686.02 mg GAE/100 g dry matter). It also exhibited strong antioxidant activity, measuring 1035.81 mg TE/100 g DM in the DPPH assay and 6506.94 mg TE/100 g DM in the ABTS assay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The highest total phenolic content and antioxidant activity of Brassica oleracea var. italica were found in the hydroethanolic extract, which showed a significant high correlation. Frequent consumption of broccoli in the diet is recommended due to its high values.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">58</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Vivian Nathaly Echegaray Florian&lt;sup&gt;1&lt;/sup&gt;, Claudia Giuliana Montoya Sisniegas&lt;sup&gt;1&lt;/sup&gt;, Juan Ernesto Valdiviezo-Campos&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Estudiante de la Escuela de Nutrición, Facultad de Ciencias de la Salud, Universidad César Vallejo, Av. Larco 1770, Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Grupo de investigación en Productos Naturales. Escuela de Nutrición, Universidad César Vallejo, Av. Larco 1770, Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Angel Armando Marin Raico</style></author><author><style face="normal" font="default" size="100%">Rosa Isabel Florez Carrasco</style></author><author><style face="normal" font="default" size="100%">Jesus Eduardo Rojas Jaimes</style></author><author><style face="normal" font="default" size="100%">Juana Elvira Chavez Flores</style></author><author><style face="normal" font="default" size="100%">Jose Arenas Gamio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of the Ethanolic Extract of Chuquiraga weberbaueri Tovar on Glycemia in BALB/c Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant extracts</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">63-70</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus is one of the most prevalent diseases worldwide and is associated with many complications. While there are many drugs available to control blood glucose levels, many people cannot access them due to economic reasons. &lt;strong&gt;Object: &lt;/strong&gt;The aim of this study was to determine the hypoglycemic effect of the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; in mice induced with hyperglycemia. &lt;strong&gt;Methods: &lt;/strong&gt;The mice were divided into 6 groups: the first group served as a control group and was administered only physiological saline solution; the second group was induced to hyperglycemia with Alloxan. The following three groups were induced with Alloxan and additionally administered ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; at different concentrations of 100 mg/kg, 250 mg/kg, and 500 mg/kg respectively. The last group was administered Alloxan and glibenclamide. The glucose levels were measured for each group at 2, 4, and 24 hours after administering the extracts. &lt;strong&gt;Results: &lt;/strong&gt;The phytochemical analysis of the ethanolic extracts of the leaves of &lt;em&gt;Chuquiraga weberbaueri&lt;/em&gt; showed the presence of flavonoids, tannins, alkaloids and steroids. The ethanolic extracts (100 mg/kg at 2 hours and 250 mg/kg at 2 and 4 hours) demonstrated a decrease in blood glucose compared to the control group. In the toxicity test, the comparison between the control group and the “extract” treatment group showed that no conclusive results were observed with respect to the chuquiragua extract. &lt;strong&gt;Interpretation:&lt;/strong&gt; The results of the study showed that the ethanolic extract of &lt;em&gt;Chuquiraga weberbaueri &lt;/em&gt;showed the effect of reducing blood glucose in BALB/c mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Angel Armando Marin Raico&lt;sup&gt;1&lt;/sup&gt;, Rosa Isabel Florez Carrasco&lt;sup&gt;1&lt;/sup&gt;, Jesús Eduardo Rojas Jaimes&lt;sup&gt;1,2&lt;/sup&gt;, Juana Elvira Chávez Flores&lt;sup&gt;3&lt;/sup&gt;, José Arenas Gamio&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Medicina Humana, Universidad Científica del Sur, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias de la Salud, Universidad Privada del Norte, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Escuela de Farmacia y Bioquímica, Universidad Norbert Wiener, Lima-PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Departamento de Patología Clínica, Hospital Guillermo Almenara Irigoyen, Lima-PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dennis R.A. Mans</style></author><author><style face="normal" font="default" size="100%">Terrence Mawie</style></author><author><style face="normal" font="default" size="100%">Priscilla Friperson</style></author><author><style face="normal" font="default" size="100%">Meryll Djotaroeno</style></author><author><style face="normal" font="default" size="100%">Jennifer Pawirodihardjo</style></author><author><style face="normal" font="default" size="100%">Vinoj H. Sewberath Misser</style></author><author><style face="normal" font="default" size="100%">Ed P.F. Ijzerman</style></author><author><style face="normal" font="default" size="100%">Walther Jap Tjoen San</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Platelet Aggregation-Stimulatory, Antibacterial, and Cytotoxic Activities of the Fresh Stem Juice from Montrichardia arborescens Schott (Araceae) – Evidence for Wound Healing- Stimulatory Properties</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Broth microdilution</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Lack of cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Montrichardia arborescens Schott</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Platelet aggregation stimulation</style></keyword><keyword><style  face="normal" font="default" size="100%">Preliminary Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">PRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem juice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">299-306</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Montrichardia arborescens&lt;/em&gt; is traditionally used for wound healing, but without scientific evidence. In this study, the fresh stem juice was assessed for its platelet aggregation stimulatory and antibacterial activities and its safety. &lt;strong&gt;Methods: &lt;/strong&gt;The stem juice was evaluated at various dilutions for platelet aggregation-stimulatory activity in human platelet rich plasma (PRP) using norepinephrine as a positive control; antibacterial activity against &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Streptococcus pyogenes&lt;/em&gt; (gram-positive bacteria) as well as &lt;em&gt;Escherichia coli&lt;/em&gt; and Pseudomonas aeruginosa (gram-negative bacteria) in a broth microdilution method using tetracycline as a reference compound; and absence of substantial cytotoxicity against cultured CHO cells in an MTT assay. Data (means ± SDs; n ≥ 3) were evaluated for statistically significant differences (p &amp;lt; 0.05) using ANOVA with Bonferroni’s adjustments. &lt;strong&gt;Results: &lt;/strong&gt;The stem juice stimulated platelet aggregation to nearly 100% at 50% (&lt;em&gt;v/v&lt;/em&gt;) dilution and about 50% at 12.5% (&lt;em&gt;v/v&lt;/em&gt;) dilution. It did not affect the growth of &lt;em&gt;E. coli &lt;/em&gt;and &lt;em&gt;P. aeruginosa&lt;/em&gt; at 50% (&lt;em&gt;v/v&lt;/em&gt;) but partially inhibited that of &lt;em&gt;S. aureus&lt;/em&gt; at 37.5% (&lt;em&gt;v/v&lt;/em&gt;) and that of &lt;em&gt;S. pyogenes&lt;/em&gt; completely at 12.5% (&lt;em&gt;v/v&lt;/em&gt;). These effects were validated by those found with epinephrine 20 μM and tetracycline 10-60 μg/mL. CHO cell survival was only 3 ± 1% with the 50% (&lt;em&gt;v/v&lt;/em&gt;) diluted stem juice but 64 ± 2% with the 12.5% (v/v) dilution. &lt;strong&gt;Conclusion: &lt;/strong&gt;The &lt;em&gt;M. arborescens&lt;/em&gt; stem juice exhibited substantial platelet aggregation-stimulatory and antibacterial activity at 12.5% (&lt;em&gt;v/v&lt;/em&gt;) dilution which seemed safe to the normal tissues. These findings confirm its traditional use for wound healing.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">299</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dennis R.A. Mans&lt;sup&gt;1*&lt;/sup&gt;, Terrence Mawie&lt;sup&gt;2&lt;/sup&gt;, Priscilla Friperson&lt;sup&gt;1&lt;/sup&gt;, Meryll Djotaroeno&lt;sup&gt;1&lt;/sup&gt;, Jennifer Pawirodihardjo&lt;sup&gt;1&lt;/sup&gt;, Vinoj H. Sewberath Misser&lt;sup&gt;1&lt;/sup&gt;, Ed P.F. Ijzerman&lt;sup&gt;2&lt;/sup&gt;, Walther Jap Tjoen San&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, SURINAME.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Microbiology, Academic Hospital Paramaribo, Paramaribo, SURINAME.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cardiology, Academic Hospital Paramaribo, Paramaribo, SURINAME.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Citrawati</style></author><author><style face="normal" font="default" size="100%">Assyafiya Salwa</style></author><author><style face="normal" font="default" size="100%">Yuni Setyaningsih</style></author><author><style face="normal" font="default" size="100%">Cut Fauziah</style></author><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Moringa oleifera Fruit Secondary Metabolites Role in Sarcopenic Obesity via Fat Mass and Obesity-Associated Protein: An In Silico Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">and riboflavin</style></keyword><keyword><style  face="normal" font="default" size="100%">FTO protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">sarcopenic obesity (SO)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">450-457</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sarcopenic obesity (SO) refers to the coexistence of sarcopenia and obesity, pathogenic interaction between loss of skeletal muscle and function and fat-mass accumulation. Fat mass and obesityassociated (FTO) protein is one of the proteins that involved in pathophysiology of SO. &lt;em&gt;Moringa oleifera&lt;/em&gt; is one of potential drug candidates for degenerative diseases due to its various bioactive metabolites from most parts of this plant. &lt;strong&gt;Objective:&lt;/strong&gt; An&lt;em&gt; in silico&lt;/em&gt; study, employing computational methods to simulate molecular interactions through molecular docking, aims to investigate the potential of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites to interact with FTO protein. &lt;strong&gt;Methodology:&lt;/strong&gt; This study was carried out the molecular docking analysis of &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit secondary metabolites that was retrieved from database and have been screened for drug-likeness and toxicity for FTO protein inhibitor candidates. Molecular docking was using Pyrx v0.8, AutoDock 4.2.6 by AutoDockTools 1.5.7, and BIOVIA Discovery studio client 2025 as visualization tools. &lt;strong&gt;Results:&lt;/strong&gt; This study showed 9 bioactive compounds from &lt;em&gt;Moringa oleifera&lt;/em&gt; fruit is bioavailable and safe for oral drugs according to Lipinski Rule of 5 (RO5) and Oral Rat Acute Toxicity (LD50). Molecular docking results showed riboflavin is the most potential compound as FTO protein inhibitor as its strongest affinity and interaction in active site compared to FTO protein native ligands 3-methylthymidine (DT). &lt;strong&gt;Conclusion: &lt;/strong&gt;Therefore, &lt;em&gt;Moringa oleifera &lt;/em&gt;fruit is potential for SO therapy candidates through regulation of FTO protein activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Citrawati&lt;sup&gt;1,2&lt;/sup&gt;, Assyafiya Salwa&lt;sup&gt;1*&lt;/sup&gt;, Yuni Setyaningsih&lt;sup&gt;1,2&lt;/sup&gt;, Cut Fauziah&lt;sup&gt;1&lt;/sup&gt;, Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Centre for Moringa Oleifera, Universitas Pembangunan Nasional Veteran Jakarta, South Jakarta, Jakarta, 12450, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitrianty Sutadi Lanyumba</style></author><author><style face="normal" font="default" size="100%">Muhammad Syafar</style></author><author><style face="normal" font="default" size="100%">Darmawansyah D</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanty</style></author><author><style face="normal" font="default" size="100%">Wahiduddin W</style></author><author><style face="normal" font="default" size="100%">Faizal Fahmi</style></author><author><style face="normal" font="default" size="100%">Anang S Otoluwa</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preconception Posyandu Performance Assessment Instrument with Europan Foundation Quality Management (EFQM) Method: Indicators, Validity and Reliability</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">EFQM</style></keyword><keyword><style  face="normal" font="default" size="100%">Instrument</style></keyword><keyword><style  face="normal" font="default" size="100%">Performance Appraisal</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception Health Post</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">40-46</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Preconception Posyandu is one of the preconception women's health services created to help reduce MMR, IMR and stunting prevalence in Banggai District. This study aims to create a performance assessment instrument for the Preconception Posyandu so that it can maintain the existence of the service. The development of performance assessment indicators through Focus Discussion Group (FGD) activities using the Europan Foundation Quality Management (EFQM) method consists of using 9 variables. We involved 30 village midwives and 30 preconception women at three health centers within Luwuk City to test the performance assessment instrument. Internal reliability was assessed with Cronbach's alpha and criterion validity. The performance appraisal instrument using the EFQM method obtained development results, namely from 52 indicator questions made into 92 questions, then after testing the validity of the instrument, 81 questions were declared valid and 11 questions were invalid. The results of Cronbach's alpha value, there are 5 variables with strong reliability (alpha&amp;gt; 0.80), namely leadership variables, strategic policies, staff management and partnerships and resources, while there is 1 variable with perfect reliability (alpha&amp;gt; 0.90), namely process variables, and 3 variables with sufficient reliability (alpha &amp;gt; 0.70), namely performance outcome variables, customer satisfaction and impact on society. The questions generated from the development of indicators can be used to measure performance. The service of the Preconception Posyandu Program that has been running so far, this is evidenced by the average value of the reliability test which is 0.83, which means strong reliability.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">40</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitrianty Sutadi Lanyumba&lt;sup&gt;1,10*&lt;/sup&gt;, Muhammad Syafar&lt;sup&gt;2&lt;/sup&gt;, Darmawansyah&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Healthy Hidayanty&lt;sup&gt;5&lt;/sup&gt;, Wahiduddin&lt;sup&gt;6&lt;/sup&gt;, Faizal Fahmi&lt;sup&gt;8&lt;/sup&gt;, Anang S Otoluwa&lt;sup&gt;9,10&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Promotion, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Administration and Health Policy, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nutritionist, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;BKKBN Department, South Sulawesi Province, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Health Department, Gorontalo Province, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Faculty of Public Health, Tompotika University Luwuk Banggai, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hesti Riasari</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Siti Uswatun Hasanah</style></author><author><style face="normal" font="default" size="100%">Mia Aulia</style></author><author><style face="normal" font="default" size="100%">Khania Zavella</style></author><author><style face="normal" font="default" size="100%">Nurul Padilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantification of Phenolics, Flavonoids, and In Vitro Antioxidant Activity in Rosella and Breadfruit Leaf Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Quantification of Phenolics</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">688-698</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is a country rich in biodiversity, with numerous plant species traditionally used in medicine. One such plant is breadfruit (&lt;em&gt;Artocarpus altilis&lt;/em&gt;), whose leaves contain bioactive compounds such as flavonoids, saponins, tannins, quercetin, artocarpanone, and artoindonesianin. Another plant with high medicinal value is roselle (&lt;em&gt;Hibiscus sabdariffa L.&lt;/em&gt;), a tropical plant from the Malvaceae family known for its rich phenolic content. Both plants are widely found across Indonesia and have potential as natural antioxidants. In this study, the dry extracts were prepared using the decoction method followed by spray drying. Phytochemical screening, total phenolic and flavonoid content analysis, and antioxidant activity tests were performed using standard in vitro methods. The DE2C extract (a combination of breadfruit leaves and roselle flowers) exhibited high total phenol content at 0.953 ± 0.005 g GAE/100 g and flavonoid content at 136.97 ± 5.050 μg QE/100 g. Meanwhile, the DE3C extract showed an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 540.55 ppm in the DPPH assay. Pearson correlation analysis showed a strong positive correlation between total phenolic content and antioxidant activity (R = 0.956, p &amp;lt; 0.05), while flavonoids also showed a moderate correlation (R = 0.502, p &amp;lt; 0.05). These results confirm that phenolic compounds play a key role in the antioxidant potential of the extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hesti Riasari&lt;sup&gt;1,*&lt;/sup&gt;, Sani Nurlaela Fitriansyah&lt;sup&gt;1&lt;/sup&gt;, Siti Uswatun Hasanah&lt;sup&gt;1&lt;/sup&gt;, Mia Aulia&lt;sup&gt;1&lt;/sup&gt;, Khania Zavella&lt;sup&gt;1&lt;/sup&gt;, Nurul Padilah&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Pharmaceutical Biology, Indonesia School of Pharmacy, Bandung. INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Benti Etika</style></author><author><style face="normal" font="default" size="100%">Desy Kurniawati</style></author><author><style face="normal" font="default" size="100%">Melindra Mulia</style></author><author><style face="normal" font="default" size="100%">Rahni Darussalam</style></author><author><style face="normal" font="default" size="100%">Okta Suryani</style></author><author><style face="normal" font="default" size="100%">Edi Nasra</style></author><author><style face="normal" font="default" size="100%">Nada frista</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Adsorption of Metanil Yellow Using Flavonoid Extract from Longan Peel (Dimocarpus longan): Optimization of pH and Concentration</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adsorption</style></keyword><keyword><style  face="normal" font="default" size="100%">Batch</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Longan Peel</style></keyword><keyword><style  face="normal" font="default" size="100%">Metanil Yellow</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1315-1319</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Water pollution can come from industrial waste containing various toxic pollutants, one of which is dye. Hazardous dyes are stable and resistant to biodegradation due to their complex aromatic structure, so dyes need to be treated. Metanil Yellow is a dye that is harmful to aquatic life and the human body. One method that can be used is adsorption with the batch method because it has the advantage of low cost and simple processing. Flavonoid extracts have high potential to be used as biosorbents because they have hydroxyl and carbonyl groups. This study aims to determine the potential of flavonoid extracts to adsorb metanil yellow dye using optimum pH and solution concentration and to determine its absorption capacity. The results showed that the optimum pH obtained was at pH 2 and the optimum solution concentration was at 150 ppm with an absorption capacity of 9.22078 mg/g.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1315</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Benti Etika, Desy Kurniawati *, Melindra Mulia, Rahni Darussalam, Okta Suryani, Edi Nasra, Nada frista&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Alwy Arifin</style></author><author><style face="normal" font="default" size="100%">Amaliah Amriani AS</style></author><author><style face="normal" font="default" size="100%">Darmawansyah, Amran Razak</style></author><author><style face="normal" font="default" size="100%">Muh. Yusri Abadi</style></author><author><style face="normal" font="default" size="100%">Muhammad Al- Fajrin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Fraud Potential Control Based on Input and Process in Dadi Regional Hospital, Makassar City</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Financing system</style></keyword><keyword><style  face="normal" font="default" size="100%">JKN</style></keyword><keyword><style  face="normal" font="default" size="100%">Prevention of potential fraud</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">668-670</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The risk of large losses arising from acts of fraud (fraud) requires the government to issue Permenkes No. 16 of 2019 concerning the prevention and handling of fraud (fraud) and the imposition of administrative sanctions against fraud (fraud) in the implementation of the health insurance program. It's just that in its implementation, there are still a number of problems related to the inefficiency of Health BPJS services which ultimately indicate the occurrence of fraud. For this reason, efforts to prevent fraud are needed. This study aims to look at the input and process of fraud control at the Dadi Regional Special Hospital (RSKD) Makassar City. This study uses a qualitative approach with descriptive analysis method by selecting informants by purposive sampling. This research is seen from the input components and process components in the implementation of the National Health Insurance. The research results show that input components include policies, personnel and facilities. The process component includes driving factors and inhibiting factors for potential fraud. Factors driving the potential for fraud are differences in understanding between the verifier and the doctor in charge of the patient regarding the diagnosis, the lack of outreach about fraud prevention and the absence of a JKN anti-fraud team. Factors inhibiting potential fraud are the Implementation of Standard Operations, code of ethics, coordination between parties involved, Clinical Pathway and supervision from the SPI team (Internal Supervisory Team).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">668</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muhammad Alwy Arifin*, Amaliah Amriani AS, Darmawansyah, Amran Razak, Muh. Yusri Abadi, Muhammad Al- Fajrin&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Health Administration and Policy, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mochamad Syahroni Fardiansyah</style></author><author><style face="normal" font="default" size="100%">Tomy Lesmana</style></author><author><style face="normal" font="default" size="100%">Edwin Danardono</style></author><author><style face="normal" font="default" size="100%">Denny Septarendra</style></author><author><style face="normal" font="default" size="100%">Ismu Nugroho</style></author><author><style face="normal" font="default" size="100%">Adhitya Angga Wardhana</style></author><author><style face="normal" font="default" size="100%">Anton Sugianto</style></author><author><style face="normal" font="default" size="100%">Rena Normasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Association of CRP, Procalcitonin, Lactate, and Albumin Levels with In-Hospital Mortality Post-Definitive Laparotomy in Patients with Complicated Intra-Abdominal Infections</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Complicated intraabdominal infection</style></keyword><keyword><style  face="normal" font="default" size="100%">Damage control laparotomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory mediators</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">805-808</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Complicated intra-abdominal infection (cIAI) still has a high mortality rate due to organ dysfunction despite advances in supportive care. Unlike other sources of septicemia, cIAI requires source control surgery, which is crucial for improving outcomes. The strategy for source control varies depending on the degree of inflammation associated with cIAI; the more severe the inflammation, the less aggressive the surgery needs to be. Therefore, we need a reliable parameter to predict the degree of inflammation before any physiological rearrangement or organ dysfunction occurs due to excessive inflammation from surgery. The literature shows that CRP, procalcitonin, lactate, and albumin are associated with the degree of inflammation. Thus, it’s necessary to study about mentioned parameters for being reference determination strategy of surgery in cIAI, classical definitive laparotomy, or rapid source control laparotomy (RSCL). &lt;strong&gt;Methods: &lt;/strong&gt;We have collected data from CIAI patients at Dr. Soetomo Regional General Hospital in Surabaya, Indonesia, covering November 2022 to April 2024. Our primary focus is assessing the inflammation level associated with the compensated or decompensated phase. The decompensated phase signifies an excessive inflammatory response, with one indication being in-hospital mortality. Subsequently, we performed univariate and multivariate analyses using the SPSS program to determine which laboratory parameters (CRP, Procalcitonin, Lactate, and Albumin) are most associated with in-hospital mortality. &lt;strong&gt;Results:&lt;/strong&gt; Between November 2022 and April 2024, there were 309 patients with complicated intra-abdominal infections (cIAI). Among the patients, 61.8% were male and 38.2% were female. The majority of patients (27.17%) were aged 61-70. The causes of cIAI included perforated appendicitis (22.65%), perforated peptic ulcer (21.69%), complications from previous surgeries (18.13%), large bowel perforation (12.29%), small bowel perforation (11.33%), intraperitoneal abscess (11.33%), and other causes (2.58%). Statistically, lactate was found to be the most accurate predictor of intraoperative hemodynamic instability (p-value &amp;lt; 0.001; correlation coefficient of 0.481), followed by albumin (p-value &amp;lt; 0.001; correlation coefficient of 0.357). CRP and Procalcitonin were less accurate, with correlation coefficients of 0.182 and 0.272, respectively. The determined cut-off points for lactate and albumin were 1.94 and 2.73, for CRP and Procalcitonin were 23,24 and 47,95. Abnormal laboratory finding in our study mean CRP above cut off point, Procalcitonin above cut off point, lactate above cut off point and albumin below cut off point. More than 2 laboratories finding, in-hospital mortality 66,7%, 2 laboratory finding in-hospital mortality 42,8% and only 1 laboratory finding in-hospital mortality 28,4%. &lt;strong&gt;Conclusions&lt;/strong&gt;: CRP, Procalcitonin, Lactate and Albumin have relation statistically significant with in-hospital mortality. Lactate and albumin are better than CRP and procalcitonin in our study, and consider RSCL for more than 2 parameter abnormal laboratory findings CRP, procalcitonin, lactate or albumin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">805</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mochamad Syahroni Fardiansyah&lt;sup&gt;1&lt;/sup&gt;, Tomy Lesmana&lt;sup&gt;2*&lt;/sup&gt;, Edwin Danardono&lt;sup&gt;2&lt;/sup&gt;, Denny Septarendra&lt;sup&gt;2&lt;/sup&gt;, Ismu Nugroho&lt;sup&gt;2&lt;/sup&gt;, Adhitya Angga Wardhana&lt;sup&gt;2&lt;/sup&gt;, Anton Sugianto&lt;sup&gt;2&lt;/sup&gt;, Rena Normasari&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Trainee of Digestive Surgery, Medical Faculty, Universitas Airlangga, Soetomo General Academic Hospital, Surabaya INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Consultant of Digestive Surgery, Medical Faculty, Universitas Airlangga, Soetomo General Academic Hospital, Surabaya INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Pathology Anatomy Department, Medical Faculty, Universitas Jember, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Handayani H.</style></author><author><style face="normal" font="default" size="100%">Renny Novi P.</style></author><author><style face="normal" font="default" size="100%">Andik Ferdiantoro</style></author><author><style face="normal" font="default" size="100%">Afira Febriani S. W.</style></author><author><style face="normal" font="default" size="100%">Rifky Dwi Aditya Iryawan</style></author><author><style face="normal" font="default" size="100%">Diaz Syafrie A.</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Mochammad Aqilah Herdiansyah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Combination Bitter, Ginger, Turmeric Extract in Mice: Acute and Sub Acute Toxicity Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute and Sub Acute Toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Ginger</style></keyword><keyword><style  face="normal" font="default" size="100%">LD50.</style></keyword><keyword><style  face="normal" font="default" size="100%">SIJAKUN (bitter</style></keyword><keyword><style  face="normal" font="default" size="100%">turmeric)</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">916-922</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Herbal plants are widely used as traditional medicine for generations. Some of them are bitter, in Indonesian called Sambiloto (&lt;em&gt;Andrographis paniculata&lt;/em&gt;), red ginger in Indonesian called Jahe merah (&lt;em&gt;Zingiber officinale&lt;/em&gt; &lt;em&gt;var rubrum&lt;/em&gt;), and turmeric in Indonesian called Kunyit (&lt;em&gt;Curcuma domestica&lt;/em&gt;). This study tested extracts containing a combination of three ingredients, hereinafter named 'SIJAKUN' extract (SambIloto, JAhe, KUNyit)”. This combination has good benefits for the body, especially as an anti-inflammatory and antioxidant. This study aims to measure the acute and subacute toxic effects of 'SIJAKUN' extract. This is a true experimental study. In the acute toxicity study, the SIJAKUN extract was given to 5 groups of mice a doses of 1000 mg/kg, 2,000 mg/kg, 3,000 mg/kg, 4,000 mg/kg, and 5,000 mg/kg. After being observed for 24 hours, the number of dead mice from each group was counted to calculate the LD50 of the 'SIJAKUN' extract. Whereas in subacute toxicity, 5 groups of mice were given 0.5 ml of CMCNa solution, 'SIJAKUN' extract at doses of 25 mg/kg, 75 mg/kg, 150 mg/kg, and 25 mg/kg ibuprofen, the test substance was given orally once daily for 28 days. Then an examination was carried out: SGOT, SGPT, BUN, and serum creatinine. the results of subsequent examinations were analyzed statistically. To assess the safety of the SIJAKUN combination, it is necessary to conduct research to determine the acute and sub acut toxicity of SIJAKUN to the liver and kidneys. Based on the results of acut toxixity study conducted, no experimental animals died at one dose of 1000, 2000, 3000, 4000 and 5000 mg/kgbb ‘SIJAKUN’ extract. Based on these results, the LD50 of 'SIJAKUN' extract was above 5000 mg/kgbb. Therefore, it can be said that 'SIJAKUN' extract is a non-toxic compound. In the subacute toxicity study, examination result of SGOT, SGPT, BUN, and serum creatinin was not change significantly, with P value &amp;gt; 0.05. This result indicating no significant difference between the control group and the treatment group. It can be said that the sub-acute toxicity test found that 'SIJAKUN' extract did not toxic for liver and kidney. In acute and subacute toxicity studies that has been carried out, 'SIJAKUN' extract was classified as a non-toxic compound, so it is safe to use as herbal medicine.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Handayani H.&lt;sup&gt;1&lt;/sup&gt;, Renny Novi P.&lt;sup&gt;1&lt;/sup&gt;, Andik Ferdiantoro&lt;sup&gt;1&lt;/sup&gt;, Afira Febriani S. W.&lt;sup&gt;1&lt;/sup&gt;, Rifky Dwi Aditya Iryawan&lt;sup&gt;1&lt;/sup&gt;, Diaz Syafrie A.&lt;sup&gt;1&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;2,3*&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;4,5,6,7&lt;/sup&gt;, Mochammad Aqilah Herdiansyah&lt;sup&gt;6,7,8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine,&amp;nbsp;Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences,&amp;nbsp;Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and&amp;nbsp;Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Postgraduate School,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences,&amp;nbsp;Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Virtual Research Center for&amp;nbsp;Bioinformatics and Biotechnology, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Division of Research and Development,&amp;nbsp;Jalan Tengah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Science and Technology,&amp;nbsp;Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Engla Merizka</style></author><author><style face="normal" font="default" size="100%">Septelia Inawati Wanandi</style></author><author><style face="normal" font="default" size="100%">Budiman Bela</style></author><author><style face="normal" font="default" size="100%">Silvia Tri Widyaningtyas</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Analysis Molecular Simulation IL6R Alpha with TCZ and HIL6: Mechanism in Inflammatory Responses</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Binding affinity</style></keyword><keyword><style  face="normal" font="default" size="100%">HIL6</style></keyword><keyword><style  face="normal" font="default" size="100%">IL6</style></keyword><keyword><style  face="normal" font="default" size="100%">IL6R</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular dynamics.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">738-743</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In cases of inflammation, there is typically a connection between IL6R and HIL6. If there is an excessive level of activity in this connection, it can lead to a cytokine storm. Tocilizumab (TCZ), also known as AntiIL-6R, is a biologic drug that is a recombinant humanized monoclonal antibody. It is specifically used to treat inflammatory and autoimmune diseases that are associated with cytokine storms. &lt;strong&gt;Method:&lt;/strong&gt; This study utilizes in silico analysis to assess the ability of TCZ, a biosimilar, to block IL6R and compares it to the blocking effect of HIL6. Validation of the 3D structure of the IL6R was performed using a Ramachandran plot. &lt;strong&gt;Results&lt;/strong&gt;: The IL6R alpha subunit had a validation score of 97.86%, while the IL6R beta subunit had a validation value of 95.54%. The molecular docking analysis reveals that the TCZ light chain forms a complex with IL6R, yielding a docking score of -16.4 kcal mol-1. Similarly, the TCZ heavy chain also interacts with IL6R, resulting in a docking value of -15.5 kcal mol-1. Notably, both scores are higher than the docking score of the control, which involves IL6R with HIL6, measuring -12.5 kcal mol- 1. The root mean square fluctuation (RMSF) value of the IL6R protein in the presence of TCZ (Tocilizumab) is consistently below 2, with an average range of 0.04-0.09. &lt;strong&gt;Conclusion&lt;/strong&gt;: The affinity between IL6R and TCZ is greater than the affinity between IL6R and HIL6.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">738</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Engla Merizka&lt;sup&gt;1,2&lt;/sup&gt;, Septelia Inawati Wanandi&lt;sup&gt;3,4*&lt;/sup&gt;, Budiman Bela&lt;sup&gt;5,6&lt;/sup&gt;, Silvia Tri Widyaningtyas&lt;sup&gt;6&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;7,8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Science, Faculty of Medicine,&amp;nbsp;Universitas Indonesia, 10430 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;sup&gt;2&lt;/sup&gt;Diploma Programs for Medical Technology, Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof.DR.HAMKA, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Molecular Biology and Proteomics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Microbiology, Faculty of Medicine,&amp;nbsp;Universitas Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Virology and Cancer&amp;nbsp;Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, 10430 Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine,&amp;nbsp;Universitas Indonesia, Jalan Salemba Raya number 4, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Bioinformatics Core Facilities -&amp;nbsp;IMERI, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya number 6, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meity Ardiana</style></author><author><style face="normal" font="default" size="100%">Nastiti Imana Intansari</style></author><author><style face="normal" font="default" size="100%">Asiyah Nurul Fadila</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Consequences of Hypertension and Obesity on Coronary Heart Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Body Mass Index</style></keyword><keyword><style  face="normal" font="default" size="100%">Cardiovascular Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Coronary Heart Disease</style></keyword><keyword><style  face="normal" font="default" size="100%">High blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1331-1335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Coronary heart disease (CHD) is the leading cause of death worldwide. At present, more than 20 million adults suffer from CHD, and the number keeps increasing. Hypertension and obesity, known risk factors of CHD, are also inclining in prevalence. Given the diversities of world population, studies on correlation of hypertension and obesity in the incidence of CHD still have a lot to unveil. &lt;strong&gt;Aim:&lt;/strong&gt; to analyze the association between hypertension and obesity to CHD as both independent and dependent risk factors. &lt;strong&gt;Method: &lt;/strong&gt;A cross-sectional descriptive study on 100 hypertensive subjects was conducted from March to November 2022. Subjects were selected by simple random sampling technique. The data were collected by anamnesis, physical examination, laboratory examination, electrocardiography, and by checking on medical records if needed. Statistical analysis was conducted using SPSS. &lt;strong&gt;Result:&lt;/strong&gt; The mean age of the study samples was 58.64 years old. The mean value of BMI was 25.77 ± 5.21 SD, and 53.6% of the participants was obese. 33% of the subjects were diagnosed with CHD. There was no correlation between obesity and CHD (OR = 0.582, 95% CI = 0.245-1.382); between hypertension on therapy or without therapy and CHD (OR= 0.729, 95% CI= 0.15-15.09). There was also no correlation between length of hypertension and CHD (R= 0.117; p = 0.27). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study shows no significant correlations between hypertension, obesity, and CHD. Whether socioeconomic and demographic profile play a part in the association of hypertension and obesity with CHD, specifically for Indonesian ethnicities, should be studied further.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1331</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meity Ardiana¹'², Nastiti Imana Intansari¹'²*, Asiyah Nurul Fadila¹'²&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lailatul Fadliyah</style></author><author><style face="normal" font="default" size="100%">Hendy Hendarto</style></author><author><style face="normal" font="default" size="100%">Lestari Sudaryanti</style></author><author><style face="normal" font="default" size="100%">Imam Susilo</style></author><author><style face="normal" font="default" size="100%">Anwar Ma’ruf</style></author><author><style face="normal" font="default" size="100%">Emuliana Sulpat</style></author><author><style face="normal" font="default" size="100%">Endah Sri Wijayanti</style></author><author><style face="normal" font="default" size="100%">Maya Septriana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect Ethanol Extract of Phyllanthus niruri l on Malondialdehyde (MDA) Expression and Extracellular Signal- Regulated Protein Kinase-1 (ERK-1) on Vaginal Epithelial Cell Thickness in Menopausal Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ERK-1</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Menopausal Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri l</style></keyword><keyword><style  face="normal" font="default" size="100%">Vaginal epithelium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1305-1310</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Menopause is the condition of the ovaries stops produce estrogen so that resulting in vaginal bleeding atrophy that is become dry cause pain moment relate sexual so that lower quality life. The ROS pathway with MAPK regulates proliferation, differentiation, motility, and survival cell life. Research purposes is know influence giving extract Phyllanthus niruri l against Malondialdehyde (MDA) expression and Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) expression against thickness cell vaginal epithelium of menopausal model mice. Material from Phillantus niruri l processed become extract. Treatment animal try mice (mus muscullus) first acclimatized during one next week done ovariectomy of both ovaries, after two weeks checked vaginal examination to be sure phase diestrus (menopause). Stage treatment given extract for 21 days with dose different 14 mg, 28 mg and 56 mg/20gBW/ day. &lt;strong&gt;Methods: &lt;/strong&gt;True Experimental research method with Post Test only with control group design. Data analysis used one way ANOVA. &lt;strong&gt;Results: &lt;/strong&gt;The research group that produced the highest average expression of Malondialdehyde (MDA) was the control group. The highest expression of Extracellular Signal-Regulated Protein Kinase-1 (ERK-1) was in the P3 treatment group (dose 56 mg/20gBW/day). The results of statistical analysis showed that there was a significant effect of Phyllanthus niruri l extract on decreasing MDA expression with a sig value of 0.000 &amp;lt; p = 21 0.001 and increasing ERK-1 with a sig value of 0.000 &amp;lt; 0.001, but there was no effect on increasing the thickness of the vaginal wall epithelial cells in menopausal model mice. with a sig value of 0.220 &amp;gt; 0.05. &lt;strong&gt;Conclusion: &lt;/strong&gt;The three doses of phillantus niruri decreased MDA and increased ERK-1. The Folin-Ciocalteau.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1305</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lailatul Fadliyah&lt;sup&gt;1,5&lt;/sup&gt;, Hendy Hendarto&lt;sup&gt;2*&lt;/sup&gt;, Lestari Sudaryanti&lt;sup&gt;3&lt;/sup&gt;, Imam Susilo&lt;sup&gt;4&lt;/sup&gt;, Anwar Ma’ruf&lt;sup&gt;5&lt;/sup&gt;, Emuliana Sulpat&lt;sup&gt;5&lt;/sup&gt;, Endah Sri Wijayanti&lt;sup&gt;5&lt;/sup&gt;, Maya Septriana&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Obstetric Gynecology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Midwifery Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Vocational Studies, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Jiang Xi University of Traditional Chinese Medicine, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mila Islamia</style></author><author><style face="normal" font="default" size="100%">Abul Fauzi</style></author><author><style face="normal" font="default" size="100%">Eka Prasetiawaty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Conservative Vs Surgical Therapy on the Quality of Life of Patients with Maxillofacial Trauma: A Systematic Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">conservative treatment</style></keyword><keyword><style  face="normal" font="default" size="100%">Maxillofacial trauma</style></keyword><keyword><style  face="normal" font="default" size="100%">MMF</style></keyword><keyword><style  face="normal" font="default" size="100%">ORIF</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality of life</style></keyword><keyword><style  face="normal" font="default" size="100%">surgical treatment</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1218-1222</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Selecting the best treatment strategy for maxillofacial trauma patients has grown challenging as a result of the continuous discussion on how different therapies affect these patients' quality of life. The purpose of this research is to methodically evaluate how conservative care and surgical care affect patients with maxillofacial trauma's quality of life.&lt;strong&gt; Methods:&lt;/strong&gt; A systematic search was undertaken using PubMed, Cochrane Library, and Wiley Online Library to locate the most recent 20 years of research comparing the effects of various treatments on the quality of life of patients with maxillofacial injuries. We also looked through relevant researchers' references to find further studies. Articles were selected by applying a search strategy based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA) guidelines.&lt;strong&gt; Results: &lt;/strong&gt;This systematic review comprised 9 comparison studies with 944 individuals in total. The findings show that patients with maxillofacial trauma had lower quality of life initially, but that after receiving therapy, their quality of life increased to varying degrees, depending on the type of treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; The majority of research revealed that patients who received MMF or ORIF did not significantly vary in terms of quality of life; however, those who were treated conservatively reported a notable improvement when compared to those who received surgical treatment (MMF/ORIF).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1218</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mila Islamia&lt;sup&gt;1&lt;/sup&gt;, Abul Fauzi&lt;sup&gt;2*&lt;/sup&gt;, Eka Prasetiawaty&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Lecturer at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Resident at the Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Lina Fitriani</style></author><author><style face="normal" font="default" size="100%">Citrakesumasari</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Sudirman Nasir</style></author><author><style face="normal" font="default" size="100%">Apik Indarty Moedjiono</style></author><author><style face="normal" font="default" size="100%">Masyitha Muis</style></author><author><style face="normal" font="default" size="100%">Nurpudji Astuti Taslim</style></author><author><style face="normal" font="default" size="100%">Sri Sumarni</style></author><author><style face="normal" font="default" size="100%">M.Bambang Uswatul Firdaus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Moringa Oleifera Plus Royal Jelly Capsules in The Gestation Age and Placenta Weight of Newborns in Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adverse Birth Outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Multiple Micronutrient Supplement</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy outcomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnant women</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1177-1182</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The incidence of adverse birth outcomes (ABO) in low- and middle-income countries (LIMC) remains significantly elevated. Moringa oleifera (MO), rich nutritional profile, offers to reduce ABO. Therefore, this study aimed to evaluate the impact of MO plus royal jelly capsules on the gestational age and placental weight of newborns in Indonesia. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; A quasi-experimental design setup in the Banggai district, Central Sulawesi Province. The study used a purposive sampling of 80 pregnant women from each sub-district. Moilong District received MRJ, while South Batui District was the Multiple Micronutrient Supplement (MMS) control group. Both groups took one capsule daily for six months. Data analysis using SPSS v28 for Windows, including Chi-square/Fisher's exact test, Kolmogorov- Smirnov test, Mann-Whitney test, and ANCOVA, with a significance level of p &amp;lt; 0.05. &lt;strong&gt;Results: &lt;/strong&gt;The demographic characteristics in both groups were similar (p &amp;gt; 0.05), except for BMI (p=0.031). Pregnancy outcomes data were also identical (p &amp;gt; 0.05). The Mann-Whitney test did not show a significant difference (p = 0.696) in the gestational age of delivery between the groups. However, there was a significant difference (p &amp;lt; 0.05) in the PW variable within the MRJ group, as shown by the Mann-Whitney test. After adjusting for BMI in PW, the ANCOVA test indicated a significant difference (p = 0.001).&lt;em&gt; Conclusions: &lt;/em&gt;The study concludes that MRJ and MMS interventions are effective and safe in preventing ABO in newborns based on gestational age and placental weight.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Lina Fitriani&lt;sup&gt;1,2*&lt;/sup&gt;, Citrakesumasari&lt;sup&gt;2&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Sudirman Nasir&lt;sup&gt;3&lt;/sup&gt;, Apik Indarty Moedjiono&lt;sup&gt;4&lt;/sup&gt;, Masyitha Muis&lt;sup&gt;5&lt;/sup&gt;, Nurpudji Astuti Taslim&lt;sup&gt;6&lt;/sup&gt;, Sri Sumarni&lt;sup&gt;7&lt;/sup&gt;, M.Bambang Uswatul Firdaus&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Health, Mega Buana University, Palopo, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Sciences, Faculty of Public Health, Universitas Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biostatistics and Demographics, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Occupational Health and Safety, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Faculty of Midicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herry Cahya Fathani</style></author><author><style face="normal" font="default" size="100%">Herdiani Sulistyo Putri</style></author><author><style face="normal" font="default" size="100%">Prananda Surya Airlangga</style></author><author><style face="normal" font="default" size="100%">Christrijogo Sumartono Waloejo</style></author><author><style face="normal" font="default" size="100%">Ira Sari Yudaniayanti</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effective Dose of Cocoa as a Preemptive Analgesic and Anti- Inflammatory Agent Assessed through Pain Scale and Tumor Necrosis Factor Alpha (TNF-α) in an Acute Pain Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cocoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Pain Degree Analgesia</style></keyword><keyword><style  face="normal" font="default" size="100%">TNF-α</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1134-1137</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pain is a significant issue for 40-50% of hospital patients, with 10-50% of acute pain cases potentially progressing to chronic pain. Pain-associated inflammation often involves the release of mediators, including Tumor Necrosis Factor Alpha (TNF-&lt;strong&gt;α&lt;/strong&gt;). Cocoa beans contain polyphenols, catechins, anthocyanidins, and proanthocyanidins, compounds believed to possess analgesic properties. This study aims to assess cocoa's potential as an oral preemptive analgesic agent in an acute pain mouse model, with an emphasis on its impact on inflammation through TNF-&lt;strong&gt;α&lt;/strong&gt; levels.&lt;strong&gt; Methods: &lt;/strong&gt;This true experimental study involved 24 male white mice split into four groups: a control group (K0) receiving a placebo, a treatment group receiving 15 mg/kg BW oral paracetamol (Kpct), a treatment group receiving 0.5 mg/g BW cocoa (K1), and a treatment group receiving 1 mg/g BW cocoa (K2). Pain response was measured using TNF-&lt;strong&gt;α&lt;/strong&gt; levels and the von Frey test. The Kruskal-Wallis test and One-Way ANOVA were employed for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;Cocoa at doses of 0.5 mg/g BW and 1 mg/g BW substantially reduced TNF-&lt;strong&gt;α&lt;/strong&gt; levels (75.82 ± 7.77 and 70.79 ± 11.50, respectively) compared to the control and paracetamol groups (98.22 ± 14.74 and 92.81 ± 2.64). On the first day, compared to the control group's 1.82 ± 0.78 von Frey values, the cocoa-treated groups' values (6.20 ± 2.72 and 7.63 ± 4.11) were notably higher. There were no notable variations in von Frey values across the groups on the second day. However, a correlation was found between von Frey values on the first and second days. &lt;strong&gt;Conclusion:&lt;/strong&gt; Cocoa can potentially serve as an effective preemptive analgesic agent, reducing pain and inflammation primarily by reducing TNF-&lt;strong&gt;α&lt;/strong&gt; levels. These results provide validity to the use of cocoa as an alternative therapy in acute pain management.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1134</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herry Cahya Fathani&lt;sup&gt;1,2&lt;/sup&gt;, Herdiani Sulistyo Putri&lt;sup&gt;1,2*&lt;/sup&gt;, Prananda Surya Airlangga&lt;sup&gt;1,2&lt;/sup&gt;, Christrijogo Sumartono Waloejo&lt;sup&gt;1,2&lt;/sup&gt;, Ira Sari Yudaniayanti&lt;sup&gt;3&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Ahmad Data Dariansyah</style></author><author><style face="normal" font="default" size="100%">Wihasto Suryaningtyas</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Prastiya Indra Gunawan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Cerebrospinal Fluid Drainage on Pro-Inflammatory and Anti-Inflammatory Cytokines Expression in the Subventricular Zone of Kaolin-Induced Hydrocephalic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">cerebrospinal fluid drainage</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaolin-induced hydrocephalus</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroinflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">subventricular zone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">20-27</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; To determine the neuroprotective effect of CSF drainage by analyzing its impact on the expression and the ratio of pro- and anti-inflammatory cytokines in the subventricular zone in kaolininduced hydrocephalic rats. &lt;strong&gt;Method:&lt;/strong&gt; Sprague-Dawley rats of 23 weeks of age (n=36) were used in this study. The rats were randomly divided into normal control, hydrocephalus, and CSF drainage-treated groups. Hydrocephalus was obtained by injecting 0,05 cc of 20% kaolin suspension into the cisterna magna. The CSF drainage-treated group had ventricular tapping seven days after kaolin induction. The rats were sacrificed 7, 14, or 21 days after kaolin induction. The brain was removed and prepared for immunohistochemistry analysis to detect IL-1&lt;em&gt;β&lt;/em&gt;, IL-6, TNF-&lt;em&gt;α&lt;/em&gt;, and IL-10 cytokines expression. &lt;strong&gt;Results: &lt;/strong&gt;Immunohistochemistry analysis revealed that the expression of pro-inflammatory cytokines was significantly increased in hydrocephalus groups than in the control group. In contrast, the expression of anti-inflammatory cytokine was significantly decreased. CSF drainage had a neuroprotective effect by reducing pro-inflammatory cytokine expression and increasing anti-inflammatory cytokine expression. In the hydrocephalus group, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 increased toward a pro-inflammatory status. After CSF drainage, the ratios of IL-1&lt;em&gt;β&lt;/em&gt;/IL-10, IL-6/IL-10, and TNF-&lt;em&gt;α&lt;/em&gt;/IL-10 shifted toward an anti-inflammatory status. &lt;strong&gt;Conclusion: &lt;/strong&gt;CSF drainage protects the brain from excessive neuroinflammatory processes in kaolin-induced hydrocephalic rats. Additional investigation is warranted to ascertain the use of inflammatory cytokines expression as a valuable biomarker for hydrocephalus. Furthermore, research on anti-inflammatory drug administration in clinical settings is required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muhammad Arifin Parenrengi&lt;sup&gt;1,*&lt;/sup&gt;, Ahmad Data Dariansyah&lt;sup&gt;1&lt;/sup&gt;, Wihasto Suryaningtyas&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;2&lt;/sup&gt;, I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;, Prastiya Indra Gunawan&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nilsya Febrika Zebua</style></author><author><style face="normal" font="default" size="100%">Nerdy Nerdy</style></author><author><style face="normal" font="default" size="100%">Kanne Dachi</style></author><author><style face="normal" font="default" size="100%">Muflihah Fujiko</style></author><author><style face="normal" font="default" size="100%">Abdi Wira Septama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnomedicine In Nias Island</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethnobotanical</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnomedicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Nias</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">186-194</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Medicinal plants have an important role in the traditional medicine system of the Nias people, which has been passed down from generation to generation. Although there has been some ethnobotanical research in Indonesia, especially in Nias, studies regarding people's knowledge, use and perception of medicinal plants on this island are still very limited. &lt;strong&gt;Objective: &lt;/strong&gt;to investigate the knowledge, use and perceptions of the Nias community towards medicinal plants. &lt;strong&gt;Design:&lt;/strong&gt; The research population involved communities in various areas of Nias, and samples were taken randomly from several villages or communities. Data collection methods include questionnaires, interviews, and observations to detail the use of medicinal plants, local knowledge, and factors that influence the choice and use of medicinal plants. The research variables involve the demographic characteristics of respondents, education level, access to health information as independent variables, while the dependent variables include the use of medicinal plants and knowledge about medicinal plants.&amp;nbsp;&lt;strong&gt;Results:&lt;/strong&gt; As a result of data collection on respondents on Nias Island, there were 50 medicinal plants that people have often used for generations to treat diseases. Data analysis involved analyzing factors related to the use of medicinal plants. It is hoped that this research will provide a better understanding of the use of medicinal plants in Nias and contribute to the preservation of local knowledge and the development of public health strategies. &lt;strong&gt;Conclusion: &lt;/strong&gt;Most of the empirical data submitted by the local Nias community is in accordance with research that has been carried out, however, there are 13 plants that need to be explored further because the empirical data does not match.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">186</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nilsya Febrika Zebua&lt;sup&gt;1&lt;/sup&gt;*, Nerdy Nerdy&lt;sup&gt;2&lt;/sup&gt;, Kanne Dachi&lt;sup&gt;3&lt;/sup&gt;, Muflihah Fujiko&lt;sup&gt;4&lt;/sup&gt;, Abdi Wira Septama&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, Universitas Tjut Nyak Dhien, Medan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK Serpong, Tangerang Selatan, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dian Mayangsari</style></author><author><style face="normal" font="default" size="100%">Lukisiari Agustini</style></author><author><style face="normal" font="default" size="100%">Susy Fatmariyanti</style></author><author><style face="normal" font="default" size="100%">Ridholia</style></author><author><style face="normal" font="default" size="100%">Pudji Lestari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of Matrix Metalloproteinase-9, Transforming Growth Factor Beta and Fibroblast in The Simblefaron Due to Alkali Burn: Literature Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkali</style></keyword><keyword><style  face="normal" font="default" size="100%">Burn</style></keyword><keyword><style  face="normal" font="default" size="100%">Conjunctiva</style></keyword><keyword><style  face="normal" font="default" size="100%">Symblepharon</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">687-690</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Simblefaron is one of the most challenging complications in the late stages of an alkali burn. Symblepharon characteristically resembles connective tissue or bands that protrude from the eyelid's interior surface (palpebral conjunctiva) to the surface of the eyeball (bulbar conjunctiva). This literature review was conducted to see the molecular mechanism of symblepharon formation. Matrix metalloproteinase (MMP- 9), transforming growth factor (TGF-β), and Fibroblast played a significant part in the healing of conjunctival wounds. MMP-9, TGF-β, and fibroblast overexpressed are suspected to cause excessive inflammation and fibrosis, which results in symblepharon. By knowing this, it is hoped that it can become a basis for developing appropriate management for the occurrence of simblepharon.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">687-690</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;Dian Mayangsari&lt;sup&gt;1&lt;/sup&gt;*, Lukisiari Agustini&lt;sup&gt;1&lt;/sup&gt;, Susy Fatmariyanti&lt;sup&gt;1&lt;/sup&gt;, Ridholia&lt;sup&gt;2&lt;/sup&gt;, Pudji Lestari&lt;sup&gt;3&lt;/sup&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga/ Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of IKM-KP, Faculty of Medicine, Universitas Airlangga/Dr. Soetomo General Academic Hospital, Surabaya, East Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anni Faridah</style></author><author><style face="normal" font="default" size="100%">Riski Gusri Utami</style></author><author><style face="normal" font="default" size="100%">Durain Parmanoan</style></author><author><style face="normal" font="default" size="100%">Risma Rahmatunisa</style></author><author><style face="normal" font="default" size="100%">Arif Adrian</style></author><author><style face="normal" font="default" size="100%">Ruhul Fitri Rosel4</style></author><author><style face="normal" font="default" size="100%">Nurul Huda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Global Research Landscape of Rendang: A Bibliometric Insight into Culinary Heritage and Innovation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bibliometric Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Food Systems</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian Cuisine</style></keyword><keyword><style  face="normal" font="default" size="100%">Rendang</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1320-1330</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Rendang, a traditional Indonesian dish, has garnered international attention for its rich flavor and cultural significance. The study aimed to analyze the global research trends related to Rendang using bibliometric methods. By examining publications, citation patterns, and key areas of focus, we aim to provide insights into the scientific community's interest and the development of research on Rendang. The analysis utilized data from major academic databases, scopus.com. The search query keyword used was “Rendang” without restrictions on language, document type, or field of study. Visualization tools utilized include VOSviewer (version 1.16.18), and RStudio (Biblioshiny). A total of 63 documents were analyzed, revealing an annual growth rate of 3.06% and an average of 11.24 citations per document, with an international co-authorship rate of 9.524%. Indonesia and Malaysia emerged as the top-cited countries. The study recommends broadening Rendang research beyond descriptive studies to explore innovations in food processing, faster cooking methods, packaging, preservation, and health impacts. Further research should address sustainability, economic impacts, and increased international collaboration, aiming for more publications in high-impact journals. Additionally, the commercialization of ready-to-eat Rendang that preserves its traditional taste and the application of smart food technologies are essential for enhancing global research impact.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1320</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anni Faridah&lt;sup&gt;1*&lt;/sup&gt;, Riski Gusri Utami&lt;sup&gt;1&lt;/sup&gt;, Durain Parmanoan&lt;sup&gt;2&lt;/sup&gt;, Risma Rahmatunisa&lt;sup&gt;1&lt;/sup&gt;, Arif Adrian&lt;sup&gt;3&lt;/sup&gt;, Ruhul Fitri Rosel&lt;sup&gt;4&lt;/sup&gt;, Nurul Huda&lt;sup&gt;5,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Culinary Arts, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Mechanical Engineering, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Tourism, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Alumni of Technology and Vocational Education (PTK), Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Sustainable Agriculture, Universiti Malaysia Sabah, Sandakan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Adjunct Professor, Faculty of Fisheries and Marine Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Febria Rizky Patikawa</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">Willy Sandhika</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">HIF-1α and VEGF Expression in Adult-type Diffuse High-Grade Astrocytoma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Astrocytoma IDH mutant grade 4</style></keyword><keyword><style  face="normal" font="default" size="100%">Glioblastoma IDH wild type</style></keyword><keyword><style  face="normal" font="default" size="100%">Glioma</style></keyword><keyword><style  face="normal" font="default" size="100%">HIF-1α</style></keyword><keyword><style  face="normal" font="default" size="100%">VEGF</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">466-470</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Gliomas stand as the prevalent primary malignant brain tumors in adults with astrocytoma being more common than oligodendroglioma. Based on isocitrate dehydrogenase (IDH) status, astrocytomas are classified as astrocytoma with mutated IDH and astrocytoma with wild-type IDH (glioblastoma). Tumor growth relies on angiogenesis, a process facilitated by key factors such as Vascular Endothelial Growth Factor (VEGF) and Hypoxia Inducible Factor-1α (HIF-1α). This study aims to investigate the VEGF and HIF-1α expression profiles in grade 4 astrocytomas, encompassing both mutated IDH and wild-type IDH.&lt;strong&gt; Method:&lt;/strong&gt; This study was conducted on 43 formalin fixed paraffin embedded (FFPE) materials of surgical specimens from adult-type grade 4 astrocytoma. Immunohistochemistry with IDH1 R132H was carried out to determine the IDH status, followed by assessment of HIF-1α and VEGF expression using semi-quantitatively utilizing immunoreactive score (IRS), and categorized as negative, weak, moderate, and strong. &lt;strong&gt;Results:&lt;/strong&gt; Statistical analysis revealed no disparity in HIF-1α expression between both tumor types, nor was there a difference in VEGF expression in both tumor types, yet a positive association was established between VEGF and HIF-1α expression levels in IDH mutant and wild type of grade 4 astrocytoma with moderate strength (r=0.433). &lt;strong&gt;Conclusion:&lt;/strong&gt; HIF-1α and VEGF are positively linked, despite the IDH status, and simultaneously work to promote angiogenesis in diffuse high-grade astrocytoma.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">466</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Febria Rizky Patikawa, Dyah Fauziah*, Willy Sandhika&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yasir M. Fadhil</style></author><author><style face="normal" font="default" size="100%">Ahmed A. Al-Ali</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Impact of Hole Modification in Cement-Retained Prosthesis on Mechanical Tensile Experiment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Dental implant</style></keyword><keyword><style  face="normal" font="default" size="100%">Hybrid ceramic</style></keyword><keyword><style  face="normal" font="default" size="100%">Retention time</style></keyword><keyword><style  face="normal" font="default" size="100%">Zirconia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">450-454</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; This in vitro study aimed to compare the adhesion strength of the adhesives of four modified cement-retained methods (MCRMs) that affect the retention of two types of materials (Zirconia and hybrid ceramic/VITA Enamic). &lt;strong&gt;Methods:&lt;/strong&gt; In this in-vitro study, four cement-retained methods were used: the first is an occlusal hole with a diameter (1mm) with lateral hole with a diameter (1mm) (OLH), the second is an occlusal hole with a diameter (2mm) for screw access (OH), the third is a lingual hole for releasing the excess adhesive (1mm) (LH), and the last one is a control group (no holes). twenty-eight crowns (n=7) were fabricated for test with CAD-CAM system. The retention strength was examined by mechanical tensile experiments (MTE) in vitro using a universal testing machine, pull-off test.&lt;strong&gt; Results: &lt;/strong&gt;A statistically significant difference is seen in each material's retention strength (zirconia and hybrid ceramic). The OLH group in zirconia (257.4286 N), and in ceramic (213.5714 N). had the highest values among the other groups, subsequently, the LH groups had slight differences from the other OH and control groups. (P=0.05). &lt;strong&gt;Conclusions:&lt;/strong&gt; The use of modified cement methods had a remarkable effect on retention. In this study, the use of occlusal-lateral with (1 mm) hole (OLH) modification is more retentive than the other groups.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yasir M. Fadhil*, Ahmed A. Al-Ali&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Prosthetic Dentistry, College of Dentistry, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Dheo Shalsabilla Novel</style></author><author><style face="normal" font="default" size="100%">Herland Satriawan</style></author><author><style face="normal" font="default" size="100%">Khang Wen Goh</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Sri Suwarni</style></author><author><style face="normal" font="default" size="100%">Ria Septiana</style></author><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Mochammad Aqilah Herdiansyah</style></author><author><style face="normal" font="default" size="100%">Anni Faridah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Gene Transcription of 4-Hydroxycinnamic Acid from Broccoli Fruit (Brassica oleracea var. italica) with Estrogen Receptor Beta Protein</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brassica oleracea var. italica</style></keyword><keyword><style  face="normal" font="default" size="100%">good health and well-being.</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular interaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">791-796</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;This study aims to explore the relationship between 4-Hydroxycinnamic Acid, a compound found in broccoli fruit (&lt;em&gt;Brassica oleracea &lt;/em&gt;var. &lt;em&gt;italica&lt;/em&gt;), and Estrogen Receptor Beta Protein through &lt;em&gt;in silico&lt;/em&gt; analysis. The research was conducted using Pymol, MOE 2015, Discovery Studio 2016, and Lepinski Rule software. These tools were employed to model the structure of both the compound and protein, as well as to evaluate their interaction. The results revealed a significant interaction with a Binding Affinity of -6.4182. Moreover, the Root Mean Square Deviation (RMSD) measurements yielded a value of 3.8907, indicating the degree of agreement between the compound and protein structures. Analysis using the Lepinski Rule disclosed the characteristics of the compound 4-Hydroxycinnamic Acid, including a mass of 164, two hydrogen bond donors, three hydrogen bond acceptors, a log P value of 1.490, and a molar reactivity of 44.776. These findings provide valuable insights into the potential of 4-Hydroxycinnamic Acid in interacting with Estrogen Receptor Beta Protein, which could serve as a foundation for further research on the health benefits and therapeutic applications of this compound, contributing to the goal of good health and well-being.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">791</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahadian Zainul&lt;sup&gt;1,2,3&lt;/sup&gt;*, Dheo Shalsabilla Novel&lt;sup&gt;1,2&lt;/sup&gt;, Herland Satriawan&lt;sup&gt;4&lt;/sup&gt;, Khang Wen Goh&lt;sup&gt;5&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8&lt;/sup&gt;, Sri Suwarni&lt;sup&gt;9&lt;/sup&gt;, Ria Septiana&lt;sup&gt;10&lt;/sup&gt;, Arif Nur Muhammad Ansori&lt;sup&gt;6,11,12,13&lt;/sup&gt;, Mochammad Aqilah Herdiansyah&lt;sup&gt;12,13,14&lt;/sup&gt;, Anni Faridah&lt;sup&gt;15,16&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&amp;nbsp;&lt;sup&gt;2&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research Fellow, INTI International University, 71800, Nilai, Negeri Sembilan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Ocean and Earth Sciences, University of Malaya, 50603, Kuala Lumpur, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Data Science and Information Technology, INTI International University, Nilai, MALAYSIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Bachelor of Pharmacy, Nusaputera College of Pharmacy Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Bachelor of Pharmacy, Kendal College of Health Kendal, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Postgraduate School, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Virtual Research Center for Bioinformatics and Biotechnology, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Division of Research and Development, Jalan Tengah, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Halal Certification Division, Universitas Negeri Padang, Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Culinary Innovation Technology, Department of Family Welfare Science, Faculty of Tourism and Hospitality, Universitas Negeri Padang, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Risma Risma</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Healthy Hidayanti</style></author><author><style face="normal" font="default" size="100%">Syamsiar S.Russeng</style></author><author><style face="normal" font="default" size="100%">Apik Indarty</style></author><author><style face="normal" font="default" size="100%">Abdul Salam</style></author><author><style face="normal" font="default" size="100%">Toto Sudargo</style></author><author><style face="normal" font="default" size="100%">Abdul Fandir</style></author><author><style face="normal" font="default" size="100%">Masrif Masrif</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Intercorrelations among Hemoglobin Level, Physical Fitness, and Cognitive Score in Adolescent Girls: A Cross Sectional Study in Banggai District, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent girl</style></keyword><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemoglobin level</style></keyword><keyword><style  face="normal" font="default" size="100%">kognitif</style></keyword><keyword><style  face="normal" font="default" size="100%">Physical Fitness</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">405-409</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Iron deficiency anemia in adolescent girls can cause decreased concentration, cognitive levels and fitness. In the long term it will have an impact on low productivity and school achievement. This study aims to analyze the correlations between hemoglobin level, physical fitness and cognitive score in Anemic adolescent girls. The research design was cross-sectional, with a sample of adolescent girls aged 12–18 years (n=139). Iron status was determined by hemoglobin levels using Hemocue. Cognitive function was measured using the Culture Fair Intelligence Test (CFIT), memory scores using the Intelligenz Structure Test (ITS), and physical fitness based on the predicted VO2max using the Bleep Test. Correlation analysis uses Pearson correlation analysis. The research results showed that overall 58.3% of students experienced anemia, of which 64.1% experienced mild anemia and 32.1% experienced moderate anemia. The average value of hemoglobin levels in respondents was 11.6 mg/dl. The mean predicted VO2 max is 25.3 kg/ m2 and kognitif score 81,02 and memori score 11,01. Pearson's test results showed that there was a significant positive correlation between hemoglobin levels and predicted VO2 max (r = 0.28, p&amp;lt;0.05) and memori score (r = 0.31, p&amp;lt;0.05). There was a weak correlation between hemoglobin levels and kognitif score (r=0.17, p=0.053). &lt;strong&gt;Conclusion:&lt;/strong&gt; There is a significant relationship between hemoglobin levels and physical fitness and cognitive function. Therefore, an intervention program is needed to increase Hb levels in adolescent girls&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Risma Risma&lt;sup&gt;1,*&lt;/sup&gt;, Veni Hadju&lt;sup&gt;2&lt;/sup&gt;, Andi Zulkifli&lt;sup&gt;3&lt;/sup&gt;, Healthy Hidayanti&lt;sup&gt;2&lt;/sup&gt;, Syamsiar S.Russeng&lt;sup&gt;4&lt;/sup&gt;, Apik Indarty&lt;sup&gt;5&lt;/sup&gt;, Abdul Salam&lt;sup&gt;2&lt;/sup&gt;, Toto Sudargo&lt;sup&gt;6&lt;/sup&gt;, Abdul Fandir&lt;sup&gt;2&lt;/sup&gt;, Masrif Masrif&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, School of Public Health, Hasanuddin University, Poltekkes Kemenkes Kendari, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutrition Science, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Occupational Safety and Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Reproductive Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Poltekkes Kemenkes Jayapura, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiwuk Susantiningsih</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ani Retno Prijanti</style></author><author><style face="normal" font="default" size="100%">Novi Silvia Hardiany</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Insights into Spirulina platensis Compounds Targeting TNFa and P21 in Delaying Cellular Senescence Mechanisms: An In Silico Approach</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">p21 expression</style></keyword><keyword><style  face="normal" font="default" size="100%">Spirulina platensis</style></keyword><keyword><style  face="normal" font="default" size="100%">TNFa-induced cellular senescence</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">809-815</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;!-- x-tinymce/html --&gt;Spirulina platensis with bioactive compounds such as Phycocyanin, β-carotene, Genistein and α-glucan, have been shown to have anti-inflammatory properties. Our present study investigation utilizes an in silico methodology to examine the molecular interactions between Spirulina platensis chemicals compound with TNFa and p21. Utilizing computational techniques molecular docking, our goal is to clarify the possible pathways by which Spirulina platensis chemicals could affect these important regulators and postpone cellular senescence. Our research may shed important light on the creation of Spirulina platensis-based therapies for ageing and age-related illnesses. Our results imply that Spirulina platensis may contribute to overall cellular health and the mitigation of cellular senescence. Phycocyanin has the most negative ΔG value is -15.0 kcal/mol. Genistein has the lowest Ki value, namely 7.299 μM. The ΔG and Ki values of Genistein were lower than Quercetin. The potential chemical interactions between substances generated from Spirulina platensis and senescence pathways, including those involving TNFa and p21, are highly intriguing for the development of innovative therapeutic approaches targeted at ameliorating cellular senescence dysfunction associated with aging.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">809</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tiwuk Susantiningsih&lt;sup&gt;1,2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;3*&lt;/sup&gt;, Ani Retno Prijanti&lt;sup&gt;4&lt;/sup&gt;, Novi Silvia Hardiany&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry Faculty of Medicine, UPN Veteran Jakarta, Jakarta, 12450, INDONESIA.&lt;sup&gt; &lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Magister Program of Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman Herman</style></author><author><style face="normal" font="default" size="100%">Arsyik Ibrahim</style></author><author><style face="normal" font="default" size="100%">Junaidin Junaidin</style></author><author><style face="normal" font="default" size="100%">M. Arifuddin</style></author><author><style face="normal" font="default" size="100%">Baso Didik Hikmawan</style></author><author><style face="normal" font="default" size="100%">Siska Siska</style></author><author><style face="normal" font="default" size="100%">Tahyatul Bariroh</style></author><author><style face="normal" font="default" size="100%">Reza Yuridian Purwoko</style></author><author><style face="normal" font="default" size="100%">Lizma Febrina</style></author><author><style face="normal" font="default" size="100%">Muhammad Faisal</style></author><author><style face="normal" font="default" size="100%">Iswahyudi Iswahyudi</style></author><author><style face="normal" font="default" size="100%">Marissa Angelina</style></author><author><style face="normal" font="default" size="100%">Erwin Samsul</style></author><author><style face="normal" font="default" size="100%">Laode Rijai</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Profile and Antidiabetic Activity of Eleutherine bulbosa Mills. Bulbs from East Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bawang Dayak</style></keyword><keyword><style  face="normal" font="default" size="100%">contaminant levels evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Eleutherine bulbosa (Mill.) Urb</style></keyword><keyword><style  face="normal" font="default" size="100%">pharmacognostic profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">118-125</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Eleutherine bulbosa (Mill.) Urb., known as Bawang Dayak, is commonly found growing in Kalimantan, Indonesia. The characteristics of the environment in which the plant grows greatly influence the characteristics of the plant and its biological activity. Objective: This study aimed to determine the pharmacognostic profile and evaluate the antidiabetic activity of E. bulbosa bulb extract obtained from Kota Bangun, Kutai Kertanegara, Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; The dried powdered of E. bulbosa bulbs was extracted using two different methods (maceration and microwave-assisted extraction). The evaluation of the sample fluorescence and non-specific parameters was done. The antidiabetic activity of the extracts was conducted using streptozocin-induced mice and histopathology analysis. &lt;strong&gt;Results:&lt;/strong&gt; The fluorescence evaluation indicated various secondary metabolites contained in E. bulbosa simplicia. Non-specific parameters include drying loss (8.83±0.2611%), water content in simplicia (8.04±0.7481%), specific gravity (1.04±0.0058%), total ash content (20.3±0.1583%), acid insoluble ash content (1.70±0.0608%), ethanol content in extract (0.99±0.0017%), lead content (0.010 mg/g), cadmium (0.091 mg/g), Arsenic (0.0003 mg/g), aflatoxin (not detected), and mold/yeast (0.8 × 105 colonies/g) meet the established regulations. Meanwhile, the antidiabetic assay showed that both extracts decreased the blood glucose levels in mice during the 14 days of treatments in a dose-dependent manner. This activity is correlated with the increased repair of pancreatic beta cells as observed by histopathological analysis. &lt;strong&gt;Conclusion:&lt;/strong&gt; The dried bulbs of E. bulbosa obtained from Kota Bangun, Kutai Kertanegara, East Kalimantan, Indonesia meet the standards set as raw materials for antidiabetic herbal medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">118</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman Herman&lt;sup&gt;1&lt;/sup&gt;, Arsyik Ibrahim&lt;sup&gt;1&lt;/sup&gt;, Junaidin Junaidin&lt;sup&gt;1&lt;/sup&gt;, M. Arifuddin&lt;sup&gt;1&lt;/sup&gt;, Baso Didik Hikmawan&lt;sup&gt;1&lt;/sup&gt;, Siska Siska&lt;sup&gt;3&lt;/sup&gt;, Tahyatul Bariroh&lt;sup&gt;4&lt;/sup&gt;, Reza Yuridian Purwoko&lt;sup&gt;5&lt;/sup&gt;, Lizma Febrina&lt;sup&gt;1&lt;/sup&gt;, Muhammad Faisal&lt;sup&gt;1&lt;/sup&gt;, Iswahyudi Iswahyudi&lt;sup&gt;2&lt;/sup&gt;, Marissa Angelina&lt;sup&gt;6&lt;/sup&gt;, Erwin Samsul&lt;sup&gt;1&lt;/sup&gt;, Laode Rijai&lt;sup&gt;1&lt;/sup&gt;, Islamudin Ahmad&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmaceutical Research and Development Laboratory of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. Dr. Hamka, East Jakarta, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Research Center for Pre-Clinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Cibinong, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Research Centre for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Kompleks Puspitek Serpong, South Tangerang and 15416, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eva Krishna Sutedja</style></author><author><style face="normal" font="default" size="100%">Frizam Dwindamuldan Sutisna</style></author><author><style face="normal" font="default" size="100%">Endang Sutedja</style></author><author><style face="normal" font="default" size="100%">Kartika Ruchiatan</style></author><author><style face="normal" font="default" size="100%">Yogi Faldian</style></author><author><style face="normal" font="default" size="100%">Laila Tsaqilah</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author><author><style face="normal" font="default" size="100%">Yovan Rivanzah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Poikilodermatous Mycosis Fungoides: A Rare Case Treated with Low-Dose Methotrexate</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cutaneous T-cell lymphoma</style></keyword><keyword><style  face="normal" font="default" size="100%">Methotrexate</style></keyword><keyword><style  face="normal" font="default" size="100%">Mycosis fungoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Poikilodermatous mycosis fungoides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">276-279</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Mycosis fungoides (MF) is a subtype of cutaneous T-cell lymphoma (CTCL) and a primary cutaneous lymphoma. Poikilodermatous MF (PMF) is a rare clinical variant of MF. Systemic chemotherapy, such as methotrexate (MTX), may be administered as monotherapy or in combination at low doses in MF. A 64-year-old man with PMF has been reported. History and physical examination revealed hyperpigmented and hypopigmented macules on the chest, abdomen, both arms, back, and upper legs, along with erythematous macules on the right medial thigh. The diagnosis of PMF is based on clinical manifestations and histopathological features of atypical lymphocyte cell infiltration in the epidermis. In addition, immunohistochemical examination also supports the MF diagnosis. The patient received chemotherapy consisting of monotherapy with MTX at low doses. During the third month of observation following MTX therapy, a few of the hyperpigmented and hypopigmented macules appeared to have diminished; some of the erythematous macules had transformed into hyperpigmented macules, and there were no new lesions. The purpose of therapy is to control the disease. Administration of low-dose MTX as a monotherapy may result in clinical improvement, but further observation is necessary. PMF may have a better prognosis than other clinical variants of MF.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eva Krishna Sutedja&lt;sup&gt;1&lt;/sup&gt;*, Frizam Dwindamuldan Sutisna&lt;sup&gt;1&lt;/sup&gt;, Endang Sutedja&lt;sup&gt;1&lt;/sup&gt;, Kartika Ruchiatan&lt;sup&gt;1&lt;/sup&gt;, Yogi Faldian&lt;sup&gt;1&lt;/sup&gt;, Laila Tsaqilah&lt;sup&gt;1&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;2&lt;/sup&gt;, Yovan Rivanzah&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irzan Nurman</style></author><author><style face="normal" font="default" size="100%">Ninik Mudjihartini</style></author><author><style face="normal" font="default" size="100%">Nurhadi Ibrahim</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Muchtaruddin Mansyur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Predictive Simulation and Functional Insights of Serotonin Transporter: Ligand Interactions Explored through Database Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Database Analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Functional analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Predictive in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">Serotonin Transporter</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">52-59</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Through its ability to facilitate the absorption of serotonin into presynaptic neurons, the serotonin transporter, also known as SERT, an essential component in the control of neurotransmission. To discover SERT possible therapeutic application, it is essential to have a solid understanding of its dynamic behavior, ligand interactions, and functional consequences. Within the scope of this investigation, the predictive simulations is crucial to investigate the complexities of SERT to gain a fresh understanding of its operation. We use the 6AWN model to describe the sequence and simulate the behavior of SERT in silico. Within this simulation, we anticipate the conformational changes of SERT and its reaction to ligand binding with paroxetine, cholesterol, dodecyl-beta-D-maltose (DDM), and sodium hydrogen ion. We discover critical residues that are crucial in the interaction between ligands and proteins. They have paroxetine binding to I.172, I.172, Y.176, and F.341 are examples of hydrophobic interactions. Example of hydrogen bonds include A.96 and pi-stacking: F.341. The blockage of the serotonin transporter is the principal mechanism of action that paroxetine has. Cholesterol interacts with SERT W.500, W.500, W.500, W.500, L.504, and A.507, and it also interacts with the outward-facing conformation of this transporter in two different ways. In general, cholesterol interacts with SERT and ligands to stabilize their optimal activity and structure. DDM contact with SERT is also a part of this interaction. R.104, D.328, E.494, Y.495, G.498, P.499, T.503, F.556, L.557, S.559, P.561, Y.579, G.582, T.583, and F.586 are the numbers that are currently in use. Within the context of glucosyl transfer processes, DDM has been utilized as an acceptor. And the interaction of Na with SERT S.263, which causes a change in the structure of SERT. Serotonin transporters are present in the environment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">52</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irzan Nurman&lt;sup&gt;1,2&lt;/sup&gt;, Ninik Mudjihartini&lt;sup&gt;3&lt;/sup&gt;, Nurhadi Ibrahim&lt;sup&gt;2,4,5&lt;/sup&gt;*, Linda Erlina&lt;sup&gt;6,7&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;6,7&lt;/sup&gt;*, Muchtaruddin Mansyur&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Technology Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Neuroscience and Brain Development Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohamad Evandiar Izwardy</style></author><author><style face="normal" font="default" size="100%">Mariza Fitriati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preeclampsia: A Cardiorenal Syndrome in Obstetric Intensive Care Unit</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cardiorenal syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Preeclampsia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1439-1441</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Cardiorenal syndrome (CRS) encompasses a spectrum of disorders involving heart and kidneys. Preeclampsia and cardiovascular disease are most likely occur via oxidative stress induced endothelial dysfunction. &lt;strong&gt;Case presentation: &lt;/strong&gt;A 34-years-old woman was referred with difficulty of breathing. She had a history of preeclampsia and refractory acute kidney injury (AKI). The patient was diagnosed with severe preeclampsia, partial HELLP syndrome, acute lung edema, cardiomyopathy, CRS, anemia, hyperkalemia, hypoalbuminemia, and AKI.&lt;strong&gt; Discussion:&lt;/strong&gt; CRS and preeclampsia share similar risk factors and mechanisms including pre-existing renal or cardiac disease, diabetes, chronic hypertension, hypertriglyceridemia, obesity, metabolic syndrome, or other systemic disease. She had a history of preeclampsia and refractory AKI. Cardiac dysfunction reduce arterial blood supply and impairs venous return. Renal failure leads to the retention of water and an excessive volume demand. &lt;strong&gt;Conclusion: &lt;/strong&gt;Cardiovascular disorders leading to CRS and preeclampsia remain the leading cause of morbidity in pregnancy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Case Report</style></work-type><section><style face="normal" font="default" size="100%">1439</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohamad Evandiar Izwardy&lt;sup&gt;1*&lt;/sup&gt;, Mariza Fitriati&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anaesthesiology and Reanimation, Division of Obstetric Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Made Dessy Gangga Ayu Cinthiadewi</style></author><author><style face="normal" font="default" size="100%">Nurwasis</style></author><author><style face="normal" font="default" size="100%">Muhammad Firmansjah</style></author><author><style face="normal" font="default" size="100%">Djoko Legowo</style></author><author><style face="normal" font="default" size="100%">Ni Putu Ayu Reza Dhiyantari</style></author><author><style face="normal" font="default" size="100%">Rifat Nurfahri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Protective Effects of UV-blocking Spectacle Lenses and Class 1 UV-blocking Contact Lenses (Senofilcon A) on Superoxide Dismutase-2 and Catalase Expression in Lens Epithelial Cells Following UVB Radiation Exposure: An Experimental Study in Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CAT</style></keyword><keyword><style  face="normal" font="default" size="100%">epithelial lens</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD2</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-blocking contact lens.</style></keyword><keyword><style  face="normal" font="default" size="100%">UV-blocking spectacles</style></keyword><keyword><style  face="normal" font="default" size="100%">UVB</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">785-790</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; To determine SOD2 and CAT expression in lens epithelial cells with the protection of UVblocking spectacle lens and UV-blocking contact lenses after UVB radiation. &lt;strong&gt;Methods:&lt;/strong&gt; 32 eyes of&lt;em&gt; Rattus norvegicus&lt;/em&gt; mice were subjected to UVB radiation from Philips PL-S 9W/01 narrowband 311 nm lamps at a distance of 18 cm for 30 minutes. Divided into four groups: a control group, P1 group exposed to radiation, P2 group wearing UV-blocking spectacle lens, and P3 group wearing UV-blocking contact lens. The mice were euthanized three days later and had their eyes removed. Immunohistochemistry analysis was used to evaluate the expression of SOD2 and CAT. &lt;strong&gt;Results: &lt;/strong&gt;P1 demonstrated a statistically significant SOD2 expression (p=0.002) compared to the control group. Neither P2 nor P3 exhibited significant differences in SOD2 expression (&lt;em&gt;p&lt;/em&gt;=0.693; &lt;em&gt;p&lt;/em&gt;=0.365). The SOD2 of the P1 group was significantly different compared to the P2 and P3 groups (p=0.007; p=0.023). No statistically significant difference between groups P2 and P3 (&lt;em&gt;p&lt;/em&gt;=0.606). The CAT levels in the P1 group significantly differed from the control group (&lt;em&gt;p&lt;/em&gt;=0.001). The differences between the P2 and P3 groups and the control groups were statistically insignificant (&lt;em&gt;p&lt;/em&gt;=0.894; &lt;em&gt;p&lt;/em&gt;=0.120). CAT P1 group had a significant difference with P2 and P3 groups (&lt;em&gt;p&lt;/em&gt;=0.001; &lt;em&gt;p&lt;/em&gt;=0.033). No statistically significant difference was observed between groups P2 and P3 (&lt;em&gt;p&lt;/em&gt;=0.154). Conclusions: UV-B exposure decreases the expression of SOD2 and CAT. Both protection can provide equally good protection.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">785</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Made Dessy Gangga Ayu Cinthiadewi&lt;sup&gt;1&lt;/sup&gt;, Nurwasis&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Firmansjah&lt;sup&gt;1&lt;/sup&gt;, Djoko Legowo&lt;sup&gt;2&lt;/sup&gt;, Ni Putu Ayu Reza Dhiyantari&lt;sup&gt;1&lt;/sup&gt;, Rifat Nurfahri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr.&amp;nbsp;Soetomo General Academic Hospital / Faculty of Medicine, Airlangga University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology Veterinary, Faculty of Veterinary Medicine,&amp;nbsp;Airlangga University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amr A. Fouad</style></author><author><style face="normal" font="default" size="100%">Moataz Mohamedalhasan Ali</style></author><author><style face="normal" font="default" size="100%">Mostafa Abdel-Hamid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Punicalagin Opposes Gentamicin Nephrotoxicity in Rats: Role of Nrf2 and NF-κB Pathways</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Kidney</style></keyword><keyword><style  face="normal" font="default" size="100%">Punicalagin</style></keyword><keyword><style  face="normal" font="default" size="100%">Rats</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">126-130</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Oxidative stress, inflammation, and apoptosis are implicated in gentamicin (GEN)-induced nephrotoxicity. Punicalagin (PNG) possesses antioxidant, anti-inflammatory, and antiapoptotic effects. Objective: The aim of the present research was to investigate the possible defensive effect of PNG against nephrotoxicity caused by GEN in male Sprague-Dawley rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; GEN (80 mg/kg/day, i.p.) was administered for 8 days. Treatment with PNG (25 mg/kg/day, p.o.) for 10 days, began 2 days before GEN insult. &lt;strong&gt;Results: &lt;/strong&gt;PNG significantly decreased serum creatinine, and malondialdehyde, tumor necrosis factor-α, interleukin-6, inducible nitric oxide synthase, nuclear factor-κB p65 (NF- κB p65), and cleaved caspase-3 activity in the kidneys of GEN-challenged rats. PNG also significantly increased renal catalase, reduced glutathione, and nuclear factor erythroid 2-related factor 2 (Nrf2) in rats received GEN. Additionally, PNG markedly attenuated the histopathological kidney tissue injury caused by GEN. &lt;strong&gt;Conclusion: &lt;/strong&gt;PNG guarded against GEN-induced kidney damage in rats through its antioxidant, anti-inflammatory, and antiapoptotic effects, and by modulating the balance between Nrf2 and NF-κB pathways.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">126</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amr A. Fouad&lt;sup&gt;1,&lt;/sup&gt;*, Moataz Mohamedalhasan Ali&lt;sup&gt;2&lt;/sup&gt;, Mostafa Abdel-Hamid&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Al-Baha University, Al-Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia &amp;amp; Department of Pathology, Faculty of Medicine, University of Elimam Elmahdi, SUDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomy and Embryology, Faculty of Medicine, Al-Baha University, Al- Baha, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eva Krishna Sutedja</style></author><author><style face="normal" font="default" size="100%">Eva Yustiana</style></author><author><style face="normal" font="default" size="100%">Yogi Faldian</style></author><author><style face="normal" font="default" size="100%">Hermin Aminah Usman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Ulcerative Cutaneous Plasmacytosis of the Scalp</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cutaneous plasmacytosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypergammaglobulinemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma cell</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">378-381</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Cutaneous plasmacytosis (CP) is a rare benign disorder characterized by polyclonal proliferation of plasma cells of unknown etiology, with potential for malignant transformation. Clinical manifestations include reddish-brown macules, papules, plaques, or nodules, and, infrequently, ulcerative lesions resembling cutaneous squamous cell carcinoma (SCC) or similar cutaneous neoplasms. &lt;strong&gt;Case: &lt;/strong&gt;Herein we reported a case of ulcerative CP which was initially suspected as SCC in a 77–year–old male. Physical examination revealed an ulcer with well–defined borders, and flat edges, with a granulation tissue base on the scalp which was suggested as SCC. Histopathological features showed infiltration of mature plasma cells in the perivascular area, polyclonal plasma cell population on kappa and lambda chain immunohistochemistry, and hypergammaglobulinemia on protein electrophoresis that supported the diagnosis of CP.&lt;strong&gt; Discussion:&lt;/strong&gt; Cutaneous plasmacytosis requires a comprehensive diagnostic evaluation, which typically includes clinical examination, histopathological analysis, immunohistochemistry, ancillary tests such as protein electrophoresis, and negative results from a diagnostic workup for systemic disease. &lt;strong&gt;Conclusion:&lt;/strong&gt; The complexity of CP manifestations necessitates a rigorous diagnostic approach, enabling the differentiation of this benign condition from malignancies with similar presentations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">378</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eva Krishna Sutedja&lt;sup&gt;1,*&lt;/sup&gt;, Eva Yustiana&lt;sup&gt;1&lt;/sup&gt;, Yogi Faldian&lt;sup&gt;1&lt;/sup&gt;, Hermin Aminah Usman&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran–Dr. Hasan Sadikin General Hospital, Bandung, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmad Yanuar Safri</style></author><author><style face="normal" font="default" size="100%">Salim Harris</style></author><author><style face="normal" font="default" size="100%">Putera Dewa Haryono</style></author><author><style face="normal" font="default" size="100%">Ariane Benina Budiwan</style></author><author><style face="normal" font="default" size="100%">Eugenia Isadora</style></author><author><style face="normal" font="default" size="100%">Aisyah Fitriannisa Prawiningrum</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Unveiling Potential Therapies: Molecular Docking Analysis of CAMKK2 and Its Mutant Variants with CAMKK2 Inhibitors in Indonesian Patients with HIV-Sensory Neuropathy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CAMKK2 inhibitors</style></keyword><keyword><style  face="normal" font="default" size="100%">HIV-SN</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">mutation</style></keyword><keyword><style  face="normal" font="default" size="100%">SNP</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">46-51</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;HIV sensory neuropathy (HIV-SN) is one among many complications that impair patients’ quality of life. Studies in Asian and African populations found that single nucleotide polymorphisms (SNPs) of calcium/ calmodulin-dependent protein kinase 2 (CAMKK2) influence the risk of HIV-SN. This study attempts to explain the influence of CAMKK2 mutations on HIV SN by studying bioinformatics interactions between CAMKK2, its mutants, and their inhibitors by molecular docking with AutoDock in order to observe their interactions with CAMKK2 inhibitors. Results showed that CAMKK2’s binding energy with its native ligand (ATP) is stronger than the mutant variant of CAMKK2MT85 and CAMKK2MT363. Conversely, interaction between CAMKK2 and its inhibitors (KN-93, STO-609, and trifluoperazine) have the lowest mean binding energy compared to CAMKK2MT85 and CAMKK2MT363. This indicates that the mutant variants have weaker interactions with the native ligand and the inhibitors, therefore disrupting the normal function of CAMKK2, its interactions with the inhibitors, while increasing the likelihood of HIV-SN.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">46</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ahmad Yanuar Safri&lt;sup&gt;1,2,3,&lt;/sup&gt;*, Salim Harris&lt;sup&gt;2,3&lt;/sup&gt;, Putera Dewa Haryono&lt;sup&gt;2,3&lt;/sup&gt;, Ariane Benina Budiwan&lt;sup&gt;2,3&lt;/sup&gt;, Eugenia Isadora&lt;sup&gt;2,3&lt;/sup&gt;, Aisyah Fitriannisa Prawiningrum&lt;sup&gt;4&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Neurology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Neurology Department, Cipto Mangunkusumo Hospital, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Bioinformatics Core Facilities IMERI, Medical Chemistry Department, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Susana Rubio-Guevara</style></author><author><style face="normal" font="default" size="100%">Olga Castillo-Medina</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Marleni Villacorta-Zavaleta</style></author><author><style face="normal" font="default" size="100%">Dan Altamirano-Sarmiento</style></author><author><style face="normal" font="default" size="100%">Elena Caceres-Andonaire</style></author><author><style face="normal" font="default" size="100%">Matilde Farias</style></author><author><style face="normal" font="default" size="100%">Nayly Chinchay</style></author><author><style face="normal" font="default" size="100%">Claudia Guerrero</style></author><author><style face="normal" font="default" size="100%">Josue Flores</style></author><author><style face="normal" font="default" size="100%">Edgar Vilela</style></author><author><style face="normal" font="default" size="100%">Sidny Nunez</style></author><author><style face="normal" font="default" size="100%">Janina Sernaque</style></author><author><style face="normal" font="default" size="100%">Felipe Pacherres</style></author><author><style face="normal" font="default" size="100%">Gabriela Mena</style></author><author><style face="normal" font="default" size="100%">Maria Trillo</style></author><author><style face="normal" font="default" size="100%">Julio Amayo</style></author><author><style face="normal" font="default" size="100%">Karyn Olascuaga-Castillo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Vaccinium corymbosum: Phenolic Compound Content and Effect of Fruit Extract on Blood Glucose in Healthy Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Blueberry</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycemic Effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Type 2 Diabetes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">716-725</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; In the context of the increasing prevalence of metabolic diseases such as diabetes, the search for natural compounds with potential impact on glycemic regulation has become a crucial area of research. Among the numerous options available, &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; extract, commonly known as &quot;blueberry&quot;, has emerged as a promising candidate due to its rich composition of phytochemicals with antioxidant, anti-inflammatory and hypoglycemic properties. The aim of this study was to determine the total phenolic content (TPC) and the activity of &lt;em&gt;Vaccinium corymbosum&lt;/em&gt; (&quot;blueberry&quot;) fruit extract on glycemia in healthy mice. &lt;strong&gt;Methods: &lt;/strong&gt;The Folin-Ciocalteau method was applied in order to quantify the phenolic compounds and the BE was administered to 25 mice distributed in six groups: control, negative control, experimental-D1- D2-D3, which were administered the BE in doses of 40, 80 and 120 mg/kg b.w. respectively; and insulin group; which were subjected to the glucose tolerance test (GTT) taking blood samples after 30, 60, 120 and 180 minutes. &lt;strong&gt;Results:&lt;/strong&gt; The total phenolic content (TPC) amount found in the berries was 3.79±0.06 GAE/dry weight (mg/g) and 18.96±0.28 GAE/solution (mg/L). Statistically significant differences were observed between the three doses of BE and the negative control during GTT as well as induced a significant reduction in area under the curve (AUC) compared to the negative control. &lt;strong&gt;Conclusions:&lt;/strong&gt; the three doses of the BE decreased glucose levels being the dose of 40 mg/kg b.w. the one that produced a statistically significant decrease with respect to the doses of 80 and 120 mg/kg b.w. during GTT.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">716</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Susana Rubio-Guevara&lt;sup&gt;1,2&lt;/sup&gt;, Olga Castillo-Medina&lt;sup&gt;1&lt;/sup&gt;, Marleni Villacorta- Zavaleta&lt;sup&gt;1&lt;/sup&gt;, Cyntia Blanco-Olano&lt;sup&gt;1&lt;/sup&gt;, Dan Altamirano-Sarmiento&lt;sup&gt;1&lt;/sup&gt;, Elena Cáceres-Andonaire&lt;sup&gt;1&lt;/sup&gt;, Matilde Farias&lt;sup&gt;2&lt;/sup&gt;, Nayly Chinchay&lt;sup&gt;2&lt;/sup&gt;, Claudia Guerrero&lt;sup&gt;2&lt;/sup&gt;, Josue Flores&lt;sup&gt;2&lt;/sup&gt;, Edgar Vilela&lt;sup&gt;2&lt;/sup&gt;, Sidny Nunez&lt;sup&gt;2&lt;/sup&gt;, Janina Sernaque&lt;sup&gt;2&lt;/sup&gt;, Felipe Pacherres&lt;sup&gt;2&lt;/sup&gt;, Gabriela Mena&lt;sup&gt;2&lt;/sup&gt;, Maria Trillo&lt;sup&gt;2&lt;/sup&gt;, Julio Amayo&lt;sup&gt;2&lt;/sup&gt;, Karyn Olascuaga-Castillo&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PharmaScience Research Group. Pharmacology Laboratory. School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Trujillo. PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Human Medicine.&amp;nbsp;Universidad Privada Antenor Orrego. Piura. PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hartono Kahar</style></author><author><style face="normal" font="default" size="100%">Sari Prabandari Prasetyaningrum</style></author><author><style face="normal" font="default" size="100%">Munawaroh Fitriah</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Analysis of Covid-19 Neutralizing Antibody Levels Post Vaccination using Ichroma™ and iFlash Covid-19 Nab</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ichroma</style></keyword><keyword><style  face="normal" font="default" size="100%">iFlash.</style></keyword><keyword><style  face="normal" font="default" size="100%">Neutralizing Antibody</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">171-174</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; One of the efforts to control SARS-CoV-2 infection in health workers is vaccination. In this study, the levels of SARS-CoV-2 neutralizing antibody (nAb) in health workers were measured with Ichroma and iFlash. &lt;strong&gt;Methods:&lt;/strong&gt; This study applied an observational analytic design with a prospective cohort and was conducted at Dr. Soetomo Regional Public Hospital, Surabaya, from January to November 2021. The population of this study included a total of 75 health workers after taking the second dose of the SARS-CoV-2 (Sinovac) vaccine. The Covid-19 NAb levels of the population were tested with Ichroma and iFlash on day 0 before vaccination, as well as days 14 and 28, and months 3 and 6 after vaccination. &lt;strong&gt;Results: &lt;/strong&gt;The Friedman test indicated a significant difference in NAb levels according to the iFlash test on day 14, day 28, month 3, and month 6 compared to those before vaccination (p &amp;lt; 0.05). The Wilcoxon test revealed a significant difference in NAb levels on day 14, day 28, month 3, and month 6. The results of the Cochran test showed a significant difference in the positivity of NAb according to the Ichroma test on day 14, day 28, month 3, and month 6 compared to those before vaccination (p &amp;lt; 0.05). McNemar's test demonstrated that the COI at month 3 was not significantly different from that before vaccination; The COI at month 6 was not significantly different from those at days 14 and 28. The results of the Pearson correlation test and Bland–Altman plot indicated a moderate correlation between Ichroma and iFlash (r = 0.592, p = 0.002).&lt;strong&gt; Conclusion:&lt;/strong&gt; Neutralizing antibodies for Covid-19 were formed after day 14 and started to increase on day 28 and started to decrease in months 3 and 6. The levels of NAb for Covid-19 were measured with Ichroma and iFlash in roughly the same pattern and had a moderate positive correlation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">171</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hartono Kahar&lt;sup&gt;1,*&lt;/sup&gt;, Sari Prabandari Prasetyaningrum&lt;sup&gt;2&lt;/sup&gt;, Munawaroh Fitriah&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2&lt;/sup&gt;, Jusak Nugraha&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory Instalation, Dr. Soetomo Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Clinical Pathology Specialization Program, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Niken Pratiwi</style></author><author><style face="normal" font="default" size="100%">Rutmauli Hutagaol</style></author><author><style face="normal" font="default" size="100%">Marwansyah</style></author><author><style face="normal" font="default" size="100%">Muhammad Pahruddin</style></author><author><style face="normal" font="default" size="100%">Erna Fauziah</style></author><author><style face="normal" font="default" size="100%">Parellangi</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Hb Levels Given Iron Supplements with and  Without Vitamin B12 to Anemia Female Industrial Workers in  Surakarta Residency Area</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron Deficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron Supplements</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin B12</style></keyword><keyword><style  face="normal" font="default" size="100%">Women Industrial Workers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1010-1015</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The research objective was to analyze the comparison of Hb levels given iron supplements with and without vitamin B12 in female industrial workers who experience anemia.&lt;strong&gt; Method: &lt;/strong&gt;The study used an experiment with a pretest-posttest control group design. The research respondents were female industrial workers who experienced anemia in the Surakarta Residency Area. The sampling method was carried out by purposive sampling. The number of samples was 33 respondents divided into a treatment group of 17 respondents and a treatment group of 16 respondents. &lt;strong&gt;Results:&lt;/strong&gt; There was no significant difference in hemoglobin levels in the control group and the treatment group as indicated by a p&amp;gt;0.05. The results of the paired t-test statistic showed that there was a significant change in hemoglobin levels in the treatment group (0,96 ± 0,40) p 0,000 (p&amp;lt;0,05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Giving iron supplementation to anemic women workers can increase hemoglobin levels. Handling of anemia in female workers can be done by making iron supplementation programs and policies in all companies that employ female workers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1010</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Niken Pratiwi&lt;sup&gt;1&lt;/sup&gt; , Rutmauli Hutagaol&lt;sup&gt;1,&lt;/sup&gt;*, Marwansyah1 , Muhammad Pahruddin&lt;sup&gt;1&lt;/sup&gt; , Erna Fauziah&lt;sup&gt;1&lt;/sup&gt; , Parellangi&lt;sup&gt;1&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;2 &lt;/sup&gt;, Sukri Palutturi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Health Polytechnic Banjarmasin of Health Ministry, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Madyawati Latief</style></author><author><style face="normal" font="default" size="100%">Rahmani</style></author><author><style face="normal" font="default" size="100%">Arliangga Fahrezi</style></author><author><style face="normal" font="default" size="100%">Sutrisno</style></author><author><style face="normal" font="default" size="100%">Indra Lasmana Tarigan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of the Anti-Inflammatory Activity of Flavonoid  Bioactive Compounds Acetone Fraction and Steroid Fraction  Ethyl Acetate Sungkai Leaves In Vivo and In Silico Studies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflamatory; β-Sitesterol; Naringenin</style></keyword><keyword><style  face="normal" font="default" size="100%">P. canescens Jack</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1068-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;One of the medicinal plants that is widely used by traditional communities is sungkai (&lt;em&gt;Peronema canescens &lt;/em&gt;Jack), which is known to contain secondary metabolite compounds of flavonoids, saponins, tannins, steroids, terpenoids, alkaloids, and phenols. This research aims to isolate secondary metabolite compounds from acetone and ethyl acetate fractions, which act as anti-inflammatory agents in vivo and in silico. Acetone and ethyl acetate fractions were isolated and characterized using UV-Vis and FT-IR. The In Vivo test was carried out on Mus musculus, while the In Silico test was carried out using the IL-10 and IFN-γ receptors, which play a role in inflammation and immunity. Our research results showed that the ethanolic (F1) and n-hexane (F2) fractions of &lt;em&gt;P. canescens &lt;/em&gt;extract had good anti-inflammatory activity with percent inhibition values of 58.12% and 56.59%, respectively. The characterization results showed that isolate F1 was a flavonoid group, Naringenin compound, while isolate F2 was a steroid group, &lt;em&gt;β&lt;/em&gt;-Sitosterol compound. Moreover, from the scoring docking results, &lt;em&gt;β-&lt;/em&gt;Sitesterol has tremendous potential as an anti-inflammatory than the compound naringenin.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1068</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Madyawati Latief&lt;sup&gt;1,2&lt;/sup&gt;, Rahmani1 , Arliangga Fahrezi&lt;sup&gt;1&lt;/sup&gt; , Sutrisno&lt;sup&gt;1 &lt;/sup&gt;, Indra Lasmana Tarigan&lt;sup&gt;1,2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Product and Bioactive Compound Laboratory, Faculty of Science and Technology, Universitas Jambi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Adrul Fauzan</style></author><author><style face="normal" font="default" size="100%">Salman Umar</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Complete Blood Profile after administration of Hydrocotyle sibthorpioides Lam. extract in capsule form</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Banded neutrophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Basophils</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophils</style></keyword><keyword><style  face="normal" font="default" size="100%">erythrocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Haematology</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemoglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematocrit</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotile sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunostimulants</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Monocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Segmented neutrophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Thrombocytes.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">375-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) has been studied as an immunostimulant, increasing macrophage cell activity and phagocytosis capacity. Based on that circumstance, the study aims to prove the immunostimulating effect by measuring the activity of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract in the capsule for the complete blood profile of healthy volunteers. The number of volunteers used was twenty people, and the volunteers were divided into two groups. The first group was given a placebo capsule without &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract. The second group was given a capsule with &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract with a dose of 67 mg, which was taken once a day for three days. Blood sampling was obtained before and after taking the capsule preparation. Observation of the complete blood profile was conducted by investigating changes in blood parameters such as haemoglobin levels, number of erythrocytes, number of leukocytes, hematocrit values, number of thrombocytes and the percentage of leukocyte types (banded neutrophils, segmented neutrophils, eosinophils, basophils, monocytes, and lymphocytes). The second group given &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. extract showed a significant effect on the increase in haemoglobin levels, number of thrombocytes and hematocrit values (p&amp;lt;0.05). The percentage of leukocyte type values showed that lymphocytes increased significantly (p&amp;lt;0.05). In contrast, the segmented neutrophil increased but did not show a significant difference with the percentage of banded neutrophils, eosinophils, basophils and monocytes (p&amp;gt;0.05). There was a nonsignificant result in all parameters for the first group, which was administrated with a placebo capsule without &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. extract.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">375</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1,*&lt;/sup&gt;, Adrul Fauzan&lt;sup&gt;2&lt;/sup&gt;, Salman Umar&lt;sup&gt;2&lt;/sup&gt; , Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Robiul Fuadi</style></author><author><style face="normal" font="default" size="100%">Jusak Nugraha</style></author><author><style face="normal" font="default" size="100%">I Gde Rurus Suryawan</style></author><author><style face="normal" font="default" size="100%">Hartono Kahar</style></author><author><style face="normal" font="default" size="100%">Aryati</style></author><author><style face="normal" font="default" size="100%">Gwenny Ichsan Prabowo</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Reny I’tishom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of Apo E Gene Polymorphism with Recurrent Acute Coronary Syndrome</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute Coronary Syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">ApoE gene</style></keyword><keyword><style  face="normal" font="default" size="100%">PCR RFLP</style></keyword><keyword><style  face="normal" font="default" size="100%">Polymorphism</style></keyword><keyword><style  face="normal" font="default" size="100%">Public Health</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">450-453</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Recurrent cardiovascular disease (CVD) incidence puts patients at higher risk for mortality and morbidity. One of the CVD symptoms is acute coronary syndrome (ACS). Many genetic polymorphisms are CVD risk factors. This study’s purpose was to investigate the correlation between recurrent ACS incidence and apolipoprotein E (ApoE) gene polymorphism.&lt;strong&gt; Method&lt;/strong&gt;: Case-control design was used in this study. About 90 patients who visited the cardiology and internal medicine clinics at UNAIR Hospital in Surabaya, Indonesia, served as the study's subjects. There were 30 patients with recurrent ACS, 30 patients with a single ACS, and 30 patients with no history of cardiovascular disease. Afterward, using the polymerase chain reaction-restriction fragment length method, the ApoE gene polymorphism examination was carried out. The Tropical Disease Center UNAIR Laboratory conducted all laboratory testing. R&lt;strong&gt;esults&lt;/strong&gt;: In the recurrent ACS group, ApoE polymorphism genotype patterns were 5 subjects for ε2ε2 (16.67%), 23 subjects for ε3ε3 (76.66%), and 2 subjects for ε4ε4 (6.67%). Meanwhile, in the single ACS group, ApoE polymorphism genotype patterns were 6 subjects for ε2ε2 (20%), 22 subjects for ε3ε3 (73.4%), 1 subject for ε4ε4 (3.33%), and 1 subject for ε2ε3 (3.33%). And, in the non- ACS group, ApoE polymorphism genotype patterns were4 subjects for ε2ε2 (13.34%), 25 subjects for ε3ε3 (83.33%), and1 subject for ε4ε4 (3.33%). There was no correlation of ApoE gene polymorphism with recurrent ACS incidence by Chi-square analysis (p &amp;gt; 0.05). &lt;strong&gt;Conclusion&lt;/strong&gt;: ApoE gene polymorphism cannot significantly affect recurrent ACS incidence.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">450</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Robiul Fuadi&lt;sup&gt;1&lt;/sup&gt;, Jusak Nugraha&lt;sup&gt;2,*&lt;/sup&gt;, I Gde Rurus Suryawan&lt;sup&gt;3&lt;/sup&gt;, Hartono Kahar&lt;sup&gt;2&lt;/sup&gt;, Aryati&lt;sup&gt;2&lt;/sup&gt;, Gwenny Ichsan Prabowo&lt;sup&gt;4&lt;/sup&gt;, Budi Utomo&lt;sup&gt;5&lt;/sup&gt;, Reny I’tishom&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Physiology and Medical Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Public Health and Preventive Medicine Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Wachid Putranto</style></author><author><style face="normal" font="default" size="100%">Septina Hestiningrum</style></author><author><style face="normal" font="default" size="100%">Nur Ismi Mustika Febriani</style></author><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Ratih Tri Kusuma Dewi</style></author><author><style face="normal" font="default" size="100%">Santy Ayu Puspita Perdhana</style></author><author><style face="normal" font="default" size="100%">Nurhasan Agung Prabowo</style></author><author><style face="normal" font="default" size="100%">Yeremia Suryo Pratama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Channa striata Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease Patients: A Randomized Controlled Trial</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Channa striata</style></keyword><keyword><style  face="normal" font="default" size="100%">End-stage renal disease</style></keyword><keyword><style  face="normal" font="default" size="100%">hs-CRP</style></keyword><keyword><style  face="normal" font="default" size="100%">Supplementation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1-5</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Albumin is a marker of nutritioinal inflammation and mortality. Chronic inflammation, as indicated by the concentration of a proinflammatory cytokine, high sensitivity C-reactive protein (hs-CRP) was reported to be high in end-stage renal disease (ESRD) patients. &lt;em&gt;Channa striata&lt;/em&gt; (CS) contains high protein that can increase albumin levels and has anti-inflammatory effects. This study was conducted to determine the effect of CS extract on serum albumin and hs-CRP on ESRD patients. &lt;strong&gt;Methods: &lt;/strong&gt;This study is a randomized, double blind, placebo-controlled study in patients with ESRD on hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD). Subjects were randomized to either a CS or a placebo group and were given a three times daily dosage of 500 mg of CS extract or 500 mg maltodextrin, respectively for 21 days. Serum albumin and hs-CRP were measured at the baseline, and at the end of the study. &lt;strong&gt;Result: &lt;/strong&gt;Forty subjects were randomized into the study with 20 in the &lt;em&gt;Channa striata &lt;/em&gt;group and 20 in the placebo group, with HD and CAPD patient evenly distributed among the group. Significant increase in serum albumin levels (p&amp;lt;0,001) and significant decrease of hs-CRP (p&amp;lt;0,001) were observed in the treatment group compared to control group at the end of the study. At the end of the study, there was no significant difference between serum albumin, hs-CRP, and their gradient between HD and CAPD patients in the intervention group. &lt;strong&gt;Conclusion: &lt;/strong&gt;CS extract results in higher serum albumin and lower hs-CRP levels compared to placebo in our population.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Wachid Putranto&lt;sup&gt;1,2,*&lt;/sup&gt;, Septina Hestiningrum&lt;sup&gt;1,2&lt;/sup&gt;, Nur Ismi Mustika Febriani&lt;sup&gt;1,2&lt;/sup&gt;, Kusmardi Kusmardi&lt;sup&gt;3&lt;/sup&gt;, Ratih Tri Kusuma Dewi&lt;sup&gt;1,2&lt;/sup&gt;, Santy Ayu Puspita Perdhana&lt;sup&gt;1,2&lt;/sup&gt;, Nurhasan Agung Prabowo&lt;sup&gt;2,4&lt;/sup&gt;, Yeremia Suryo Pratama&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Nephrology, Department of Internal Medicine, Dr. Moewardi General Hospital, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Sebelas Maret University, Surakarta, Jl. Ir. Sutami 36, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomic Pathology, Doctoral Programme Study of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Drug Development Research Cluster, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jl. Salemba Raya No.6, Jakarta, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Sebelas Maret University Hospital, Jl. A. Yani 200, Sukoharjo, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sumarawati T</style></author><author><style face="normal" font="default" size="100%">Chodidjah</style></author><author><style face="normal" font="default" size="100%">Dina Fatmawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Combination of Soybean and Phaleria macrocarpa Ethanol Extract on IL6, TNFα, VEGF and Fibroblasts in Mice Exposed to UVB</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin wound</style></keyword><keyword><style  face="normal" font="default" size="100%">UV B radiation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">6-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;UV exposure causes inflammation and the generation of reactive oxygen species, both of which contribute to skin aging. The purpose of this research was to determine how a combination of &lt;em&gt;Phaleria macrocarpa &lt;/em&gt;extract and soybean extract affected the number of fibroblasts, VEGF, IL-6, and TNF alpha expression, and blood levels of IL-6 and TNF alpha in UV-B-exposed mice. In this study, mice were placed into four groups: one control group, three treatment groups, and a combination of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;:soybeans at a 1:1 ratio (com group). The mice were euthanized on days 5 and 21 for histological preparations and then examined under a light microscope. Using an Olympus C-21 microscope with an Optilab Advances camera at 1000x magnification, the fibroblast was studied by counting the number of fibroblast cells per field of view. The immunohistochemical approach was performed to analyze the expression of VEGF, IL-6, and TNF- in skin tissue. The ELISA technique was used to quantify the levels of IL-6 and TNF-alpha. SPSS ver 21 was used to analyze the data. On days 5 and 21, the number of fibroblasts and expression of VEGF, IL-6, and TNF alpha were significantly higher in the combination group than in the control, &lt;em&gt;Phaleria macrocarpa&lt;/em&gt;, and soybean treatment groups. However, there was no significant change in IL-6 and TNF alpha levels across groups on days 5 and 21 (p &amp;gt; 0.05). Finally, a 1:1 mixture of &lt;em&gt;Phaleria macrocarpa&lt;/em&gt; and soybeans reduced the number of fibroblasts and the production of VEGF, IL-6, and TNF alpha on days 5 and 21, but not in serum levels.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">6</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sumarawati T&lt;sup&gt;1,*&lt;/sup&gt;, Chodidjah&lt;sup&gt;2&lt;/sup&gt;, Dina Fatmawati&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Anatomi, Faculty of Medicine, Universitas Islam Sultan Agung&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dinar Sari C. Wahyuni</style></author><author><style face="normal" font="default" size="100%">Siti A. E. Astuti</style></author><author><style face="normal" font="default" size="100%">Soerya Dewi Marliyana</style></author><author><style face="normal" font="default" size="100%">Yudi Rinanto</style></author><author><style face="normal" font="default" size="100%">Tiara Dewi S. Pratama</style></author><author><style face="normal" font="default" size="100%">Ahmad Fauzi</style></author><author><style face="normal" font="default" size="100%">Ari Satia Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Drying Methods on Chemical Profiling of Zingiberaceae Herbs Production</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Curcuma Genus</style></keyword><keyword><style  face="normal" font="default" size="100%">Freeze drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Multivariate</style></keyword><keyword><style  face="normal" font="default" size="100%">Oven drying</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber Genus.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">128-133</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: Drying method is one of the important steps in post-harvesting in herbal production in order to prolong the shelf-life of herbal medicine and to ensure the good quality. &lt;strong&gt;Objective&lt;/strong&gt;: This research aimed to profile and quantify the metabolites changing using metabolomic based on&lt;sup&gt; 1&lt;/sup&gt;H-NMR Spectroscopy on &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genus due to the drying process. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Five species of the &lt;em&gt;Curcuma and Zingiber &lt;/em&gt;genus were Curcuma longa &lt;em&gt;L., Curcuma&lt;/em&gt; aeruginosa Roxb., Curcuma xanthorrhiza Roxb., Zingiber officinale Roscoe. and Zingiber amaricans BI. The drying method applied were freeze drying and oven drying method at -1080C and 500C, respectively. Samples were extracted using buffer phosphate and deuterated methanol (3:7). The analysis was performed using &lt;sup&gt;1&lt;/sup&gt;H-NMR spectroscopy 400 MHz with TSP as an internal standard. The &lt;sup&gt;1&lt;/sup&gt;H-NMR spectra were analysed with multivariate (Principal Component Analysis).&lt;strong&gt; Results:&lt;/strong&gt; The relative concentrations of sucrose and fructose at 5 samples in freeze drying method showed significant higher content than those in oven drying. On the other hands, glucose was mostly significant higher concentration in oven drying at 5 samples. Fructose and sucrose were significantly higher in freeze drying method than those in oven drying in &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genera. Relative glucose content was higher in oven drying at Curcuma genus &lt;strong&gt;Conclusion:&lt;/strong&gt; Therefore, oven drying method which applied heating at 500C is an appropriate method for herbal medicine production, especially in &lt;em&gt;Curcuma and Zingiber&lt;/em&gt; genus, for maintaining the major secondary metabolites.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">128</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dinar Sari C. Wahyuni&lt;sup&gt;1,*&lt;/sup&gt;, Siti A. E. Astuti&lt;sup&gt;1&lt;/sup&gt;, Soerya Dewi Marliyana&lt;sup&gt;2&lt;/sup&gt;, Yudi Rinanto&lt;sup&gt;3&lt;/sup&gt;, Tiara Dewi S. Pratama&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fauzi&lt;sup&gt;4&lt;/sup&gt;, Ari Satia Nugraha&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacy Department, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;ChemistryDepartment, Faculty of Mathematics and Natural Sciences, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Biology Education Program, Faculty of Teacher Training and Education, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57 126, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani, Pabelan, Kartasura, Sukoharjo 57169, Central Java, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Drug Utilisation and Discovery Research Group, Faculty of Pharmacy, University of Jember, Jl. Kalimantan I/2, Jember, 68121, East Java, INDONESIA.&amp;nbsp;&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chayut Fongsuk</style></author><author><style face="normal" font="default" size="100%">Patnaree Wongmanit</style></author><author><style face="normal" font="default" size="100%">Kanoktip Pansuksan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Plant Stage and Solvent Extraction on Catechin Contents in  Borrasus flabellifer L. Male Flower</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Borrasus flabellifer L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Catechin</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Male flower</style></keyword><keyword><style  face="normal" font="default" size="100%">Mature</style></keyword><keyword><style  face="normal" font="default" size="100%">Young</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1036-1041</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Borrasus flabellifer L&lt;/em&gt;. is a plant in the Arecaceae (Palmae) family with numerous bioactivities such as diuretic promotion, antioxidant, and antimicrobial effects. In this study, we are interested in the phytochemical compounds present in &lt;em&gt;B. flabellifer &lt;/em&gt;L. male flowers. We investigated the effects of plant stage and solvent used for extraction. Initially, both the young and mature male flowers of this plant were extracted using water or ethanol. Several standard compounds, including gallic acid, catechin, caffeic acid, and quercetin, were utilized to screen the phytochemicals in these plant flowers. After analyzing the samples using High-Performance Liquid Chromatography (HPLC) method, only catechin was detected in all extracts, while the others were not detected (did not match the peak spectrum pattern compared with standard). Using a detection wavelength and curve parameters with an R2 value of 0.9999, catechin detection via HPLC was performed at 280 nm within the range of 13.12 to 210.00 µg/mL detection. Regarding the stage of the male flower, the young ones extracted with water provided the highest catechin content at 6.65 µg/mg extract, while the others fell within the range of 4.02 to 4.44 µg/mg extract. Therefore, it has been confirmed that catechin can be found in B. &lt;em&gt;flabellifer &lt;/em&gt;L., and water should be used as the solvent for extraction for further applications of this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1036</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Chayut Fongsuk&lt;sup&gt;1 &lt;/sup&gt;, Patnaree Wongmanit&lt;sup&gt;2&lt;/sup&gt; , Kanoktip Pansuksan&lt;sup&gt;3,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok, 26120, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Graduate Student in Division of Integrative Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, THAILAND.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haerani Harun</style></author><author><style face="normal" font="default" size="100%">Anwar Daud</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">M Sabir</style></author><author><style face="normal" font="default" size="100%">Veni Hadju</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Rahma</style></author><author><style face="normal" font="default" size="100%">Miranti</style></author><author><style face="normal" font="default" size="100%">Tamrin Talebe</style></author><author><style face="normal" font="default" size="100%">M. Faris</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Preconcenption Moringa Leaf Extract Supplementation on Cotinine Serum Levels in Pregnant Women Exposed to Tobacco Smoke</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cotinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera.</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Tobacco smoke</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">290-293</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Moringa oleifera &lt;/em&gt;is known for its nutrition content, antioxidant and medical benefit. Tobacco smoke contains various toxic substance and can affect the pregnancy. To reduce the tobacco smoke effect on pregnancy outcome good nutrition is needed. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to assess the effect of Moringa leaf extract on serum cotinine levels in pregnant women exposed to second-hand tobacco smoke.&lt;strong&gt; Method:&lt;/strong&gt; This is an observational study with a prospective cohort study design the study population was pregnant women which were divided by 2 groups, first group received IFA supplements only (n = 30) and the second group receive IFA and Moringa leaf extract supplements (n = 26). The tobacco smoke exposure data collected with questionnaire, and cotinine serum by blood sample. The tobacco smoke exposure and cotinine serum levels were compered between the two groups.&lt;strong&gt; Results: &lt;/strong&gt;The tobacco smoke exposures at home were higher in MO+IFA group pregnant women then the IFA group pregnant women (p&amp;lt;0,05). The cotinine serum levels in both groups were found not significantly different (p=0,535). These results indicate that pregnant woman with high exposure of tobacco smoke who MO receive have similar cotinine serum levels with the pregnant woman with lower exposure of tobacco smoke. &lt;strong&gt;Conclusion:&lt;/strong&gt; Moringa leaf extract supplementation to pregnant women with high tobacco smoke exposure has serum cotinine levels similar to pregnant women with lower exposure to tobacco smoke.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">290</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Haerani Harun&lt;sup&gt;1,*&lt;/sup&gt;, Anwar Daud&lt;sup&gt;2&lt;/sup&gt;, Ridwan Amiruddin&lt;sup&gt;3&lt;/sup&gt;, M Sabir&lt;sup&gt;4&lt;/sup&gt;, Veni Hadju&lt;sup&gt;5&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;2&lt;/sup&gt;, Rahma&lt;sup&gt;1&lt;/sup&gt;, Miranti&lt;sup&gt;4&lt;/sup&gt;, Tamrin Talebe&lt;sup&gt;6&lt;/sup&gt;, M. Faris&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Student of Doctoral Program, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Enviromental Health, Public Health Faculty Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Professor, Department of Epidemiology, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Associate Professor, Department of Microbiology,Medical faculty Tadulako University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Nutritional Sciences, Faculty of Public Health, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Associate professor, Ushuluddin Faculty, Datokarama State Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tridiganita Intan Solikhah</style></author><author><style face="normal" font="default" size="100%">Tania Anggreani Wijaya</style></author><author><style face="normal" font="default" size="100%">Salsabila</style></author><author><style face="normal" font="default" size="100%">Daffa Alice Pavita</style></author><author><style face="normal" font="default" size="100%">Ragil Kusnandar Miftakhurrozaq</style></author><author><style face="normal" font="default" size="100%">Hartanto Mulyo Raharjo</style></author><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipid Protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Manilkara zapota</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">286-289</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study is to examine the effect of sapodilla leaf extract on lipid profiles of alloxan-induced diabetic mice. This research method are 30 male mice were used as experimental animals, which were randomly divided into five groups, each group consisting of 6 mice. The division of the group is as follows: Treatment of non-diabetic mice, diabetic mice, diabetic mice by administering pioglitazone at a dose of 2 mg/kg BW, extracts of manila sapodilla leaf (&lt;em&gt;M. zapota&lt;/em&gt; L.) dose 100 mg/kg BW and 300 mg/kg BW. Observations were made on the 14th day, after administration of sapodilla leaf extract, mice were given light anesthesia and serum lipid profiles Total Cholesterol (TC), triglycerides (TG), High-Density Lipoprotein (HDL), and Low-Density Lipoprotein (LDL) were measured using diagnostic kits (Pars Azmoon Kit) and automatic analyzer (Abbot, model Alcyon 300). The results of this study are in TC, there was a significant difference in pioglitazone and 100 mg leaf extract against all treatment groups. In TG, there was a significant difference in pioglitazone and 300 mg leaf extract against all treatment groups. In LDL, there were significant differences in the 100 mg, 300 mg leaf extract and pioglitazone, against negative control, and diabetes control. In HDL, there was a significant difference in negative control and 300 mg leaf extract, against 100 mg leaf extract, pioglitazone, and diabetes control. The conclusions of this study exhibited the ethanol extract of&lt;em&gt; M. zapota&lt;/em&gt; leaves contains several phytochemical compounds including alkaloids, flavonoids, saponins, polyphenols, tannins, quinones, and steroids. &lt;em&gt;M. zapota &lt;/em&gt;leaves extract (100 mg/kg and 300 mg/kg) exhibited a significant effect on improvement in lipid protein.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">286</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tridiganita Intan Solikhah&lt;sup&gt;1,2,*&lt;/sup&gt;, Tania Anggreani Wijaya&lt;sup&gt;1,2&lt;/sup&gt;, Salsabila&lt;sup&gt;1,2&lt;/sup&gt;, Daffa Alice Pavita&lt;sup&gt;1,2&lt;/sup&gt;, Ragil Kusnandar Miftakhurrozaq&lt;sup&gt;3&lt;/sup&gt;, Hartanto Mulyo Raharjo&lt;sup&gt;4&lt;/sup&gt;, Maya Nurwartanti Yunita&lt;sup&gt;5&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Clinic, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Health and Life Science, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Universitas Jember, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Microbiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Veterinary Pathology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Division of Veterinary Clinical Pathology and Physiology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maya Nurwartanti Yunita</style></author><author><style face="normal" font="default" size="100%">Julia Calvina Fauzi</style></author><author><style face="normal" font="default" size="100%">Zahra Defitra Rahmania</style></author><author><style face="normal" font="default" size="100%">Bella Safinda</style></author><author><style face="normal" font="default" size="100%">Tridiganita Intan Sholikhah</style></author><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">M. Gandul Atik Yuliani</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Reina Puspita Rahmaniar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Single-Bulb Garlic (Allium sativum Var. Solo Garlic) Extract on The Hematological Profile In E-Cigarette-Induced Male Sprague Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">E-cigarette</style></keyword><keyword><style  face="normal" font="default" size="100%">Good health</style></keyword><keyword><style  face="normal" font="default" size="100%">Hematology profile</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">296-300</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Garlic and its derivative preparations have long been used in traditional medicine for good health. Garlic is known to act as an antioxidant, antitumor, antibacterial, and antifungal. The antioxidant compound in singlebulb garlic is considered to be better than the antioxidant content in other species of garlic. This research aimed to study the effect of hematological profile in oral administration of single-bulb garlic extract in e-cigarette-induced male &lt;em&gt;Sprague Dawley&lt;/em&gt; rats. The method used in this study was randomized post-test only control group design. Twenty-four rats were randomly distributed into six groups. The group consisted of C (-) as normal rats’ control; C (+) only exposed to e-cigarette smoke; T1 exposed to e-cigarette smoke and treated with vitamin C; T2 exposed to e-cigarette and treated with single-bulb garlic extract 75 mg/kg BW; T3 exposed to e-cigarette and treated with single-bulb garlic extract 100 mg/kg BW; and T4 exposed to e-cigarette and treated with single-bulb garlic extract 125 mg/kg BW. Exposure to e-cigarette smoke is conducted by evaporating the liquid into a gas chamber with a nicotine dose of 3.6 mg/ml. All treatments were given for 14 days. On the 15th day, the rats were sacrificed. Blood samples were collected by the cardiac puncture method and were examined using a hematology analyzer. Data obtained were white blood count (WBC), platelets, hemoglobin, hematocrit, and erythrocytes that were analyzed with one-way ANOVA. The result of this study is that garlic extract may boost immunity in the body. However, higher doses can be toxic to erythrocytes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maya Nurwartanti Yunita&lt;sup&gt;1*&lt;/sup&gt;, Julia Calvina Fauzi&lt;sup&gt;2&lt;/sup&gt;, Zahra Defitra Rahmania&lt;sup&gt;2&lt;/sup&gt;, Bella Safinda&lt;sup&gt;2&lt;/sup&gt;, Tridiganita Intan Sholikhah&lt;sup&gt;3&lt;/sup&gt;, Bodhi Agustono&lt;sup&gt;4&lt;/sup&gt;, M. Gandul Atik Yuliani&lt;sup&gt;5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;6&lt;/sup&gt;, Reina Puspita Rahmaniar&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Veterinary Pathology Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Veterinary Medicine, School of Health and Life Sciences, Universitas Airlangga, Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Clinic Veterinary Medicine Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Animal Husbandry Division, School of Health and Life Sciences, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Basic Veterinary Medicine Division, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Animal Science, Royal University of Bhutan, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Microbiology, Faculty of Veterinary Medicine, Wijaya Kusuma University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Firdaus</style></author><author><style face="normal" font="default" size="100%">Ida Leida Maria</style></author><author><style face="normal" font="default" size="100%">Ansariadi</style></author><author><style face="normal" font="default" size="100%">Andi Zulkifli</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Shanti Riskiyani</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effectiveness of the Si-DBD Application in Increasing the Number of Households in Conducting Periodic Larvae Examination at the Health Center in Bantaeng Regency</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Application</style></keyword><keyword><style  face="normal" font="default" size="100%">DHF.</style></keyword><keyword><style  face="normal" font="default" size="100%">Periodic larva inspection</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">569-574</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Vector-borne diseases, namely DHF, are estimated to infect 100-400 million people each year. Until now there is no specific drug or vaccine for DHF that can be done to avoid or prevent mosquitoes, which focuses on prevention efforts by eradicating mosquito nests. This study aims to see the effectiveness of the application system in carrying out periodic inspections by households. &lt;strong&gt;Method: &lt;/strong&gt;Quasi-experimental research type with design &quot;&lt;em&gt;The&lt;/em&gt; &lt;em&gt;Nonrandomized Control Group Pretest Posttest Design”.&lt;/em&gt; There are 112 samples with a ratio of 1:1 treatment (application system) and control (manual). Data collection using observation sheets (secondary data) and data from larvae inspection results through the application. Seeing the difference before and after the Mc test. Nemar and Chi-Square to see the difference between the treatment and control groups.&lt;strong&gt; Results&lt;/strong&gt;: Periodic larvae inspection by the household before and after manually had no difference, while the system with the application had a significant difference with a value of P=0.000. The comparison between the treatment and control groups with a value of P = 0.000 indicates that there is a difference in the number of households that carry out periodic larva inspections through an application compared to the manual method. The system with the Si-DBD application is simpler, more acceptable, and timelier in carrying out periodic larvae inspections by households with a value of P=0.000. &lt;strong&gt;Conclusion: &lt;/strong&gt;The implementation of periodic larvae inspections that is modeled by an application-based information system via a smartphone has an influence on the number of households that carry out larvae inspections compared to the manual system that is running. Follow-up testing can be carried out on a large scale of household respondents covering the entire work area of the health center and with a cohort research design.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">569</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Firdaus&lt;sup&gt;1,*&lt;/sup&gt;, Ida Leida Maria&lt;sup&gt;2&lt;/sup&gt;, Ansariadi&lt;sup&gt;2&lt;/sup&gt;, Andi Zulkifli&lt;sup&gt;2&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt;, Shanti Riskiyani&lt;sup&gt;4&lt;/sup&gt;, Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Masters Program in Field Epidemiology at the Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Nutrition Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Health Promotion and Behavioral Science, Faculty of Public Health, University of Hasanuddin, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Environmental Health, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rina Masadah</style></author><author><style face="normal" font="default" size="100%">Savira Ekawardhani</style></author><author><style face="normal" font="default" size="100%">Ramadani Eka Putra</style></author><author><style face="normal" font="default" size="100%">Dzul Ikram</style></author><author><style face="normal" font="default" size="100%">Muhammad Faruk</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethanolic Extract of Propolis from Tetragonula laeviceps: Selective  Cytotoxicity for MCF-7 Breast Cancer cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7 Breast Cancer Cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Proliferation</style></keyword><keyword><style  face="normal" font="default" size="100%">Propolis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1177-1180</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Many patients with breast cancer fail to respond to conventional chemotherapeutic agents; these agents are also associated with numerous adverse events and toxicities. These concerns have led to the ongoing search for natural ingredients with antitumor effects. As such, the aim of this study was to explore the anti-cancer properties of an ethanolic extract of propolis (EEP), a natural product derived from the stingless bee, from &lt;em&gt;Tetragonula laeviceps.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; Bioactive components of EEP were identified by gas chromatography–mass spectrometry (GC–MS) and antioxidant capacity was tested by 2.2-diphenyl1-picrylhydrazyl (DPPH) analysis. Selective cytotoxic actions of EEP on both MCF-7 and Vero cells were then evaluated using the MTT assay. Polyphenols were identified as the major components of EEP from &lt;em&gt;T. laeviceps&lt;/em&gt;. &lt;strong&gt;Results:&lt;/strong&gt; our results indicated that EEP was selectively toxic for human MCF-7 breast cancer cells and had only limited impact on African Green Monkey kidney Vero cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;EEP from T. laeviceps has bioactive components that may selectively inhibit the proliferation of cancer cells. As such, EEP may be useful source material to be used for the development of novel anti-cancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1177</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rina Masadah&lt;sup&gt;1&lt;/sup&gt; , Savira Ekawardhani&lt;sup&gt;2&lt;/sup&gt; , Ramadani Eka Putra&lt;sup&gt;3&lt;/sup&gt; , Dzul Ikram&lt;sup&gt;1,4&lt;/sup&gt;, Muhammad Faruk&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pathology Anatomy, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biomedical Science, Faculty of Medicine, Padjajaran University, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Life Sciences and Technology, Bandung Institute of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Histology, Muslim University of Indonesia, Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Mally Ghinan Sholih</style></author><author><style face="normal" font="default" size="100%">Nitya Nurul Fadilah</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Surya Amal</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Lina Aliyani Mardiana</style></author><author><style face="normal" font="default" size="100%">Diany Astuti</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antidiarrheal, Antispasmodic, and Antisecretory Activities of Extract and Fractions of Castanopsis costata Leaves in Animal Models</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal models</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diarrhea</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">31-37</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The use of traditional medicinal plants &lt;em&gt;Castanopsis costata &lt;/em&gt;in the management of diarrhea is an ancient practice in North Sumatra, Indonesia, but its safety and efficacy have not been examined scientifically in animal models. Therefore, this study aims to determine the antidiarrheal effect of &lt;em&gt;C. costata&lt;/em&gt; leaf extract and fractions&lt;em&gt; in vivo&lt;/em&gt;. &lt;strong&gt;Methods: &lt;/strong&gt;The antidiarrheal activity was evaluated against animal models of diarrhea induced by castor oil, charcoal meal, and entero-pooling test. The extract group received doses of 25, 50, 100, and 200 mg/kg, while the fraction groups was treated with WFCC, EAFCC, and nHFCC, in doses of 50 and 100 mg/kg, respectively. The negative control received 10 mL/kg of the dissolving vehicle, while the positive was treated with loperamide 3 mg/kg.&lt;strong&gt; Results&lt;/strong&gt;: The results showed that EECC doses of 200 mg/kg, WFCC, and EAFCC at 50 and 100 mg/kg, respectively significantly delayed the onset of diarrhea, while WFCC and EAFCC at 100 mg/kg significantly reduced the amount of wet feces output and total feces output. In addition, only WFCC and EAFCC (at 50 and 100 mg/kg, respectively) significantly reduced the mean weight of wet feces and total feces. The percentage of maximum diarrhea inhibition was observed at the EAFCC dose of 100 mg/kg. Based on the charcoal meal test results, only EAFCC significantly inhibited the distance traveled by charcoal meal and reduced the peristaltic index at a dose of 100 mg/kg, while the percentage decrease in gastrointestinal motility was 46.87%. Similarly, in the entero-pooling test, WFCC and EAFCC significantly reduced the volume and weight of intestinal contents at a dose of 100 mg/kg, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results confirm that the extract and fractions of &lt;em&gt;C. costata&lt;/em&gt; have antidiarrheal activity. Therefore, this study provides scientific support for the traditional use of &lt;em&gt;C. costata&lt;/em&gt; in treating diarrhea.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">31</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1,*&lt;/sup&gt;, Mally Ghinan Sholih&lt;sup&gt;2&lt;/sup&gt;, Nitya Nurul Fadilah&lt;sup&gt;3&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Surya Amal&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Lina Aliyani Mardiana&lt;sup&gt;1&lt;/sup&gt;, Diany Astuti&lt;sup&gt;1&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Buana Perjuangan Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Health Sciences, Universitas Singaperbangsa Karawang, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Health Sciences, Universitas Perjuangan Tasikmalaya, Tasikmalaya, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suresh Chandra Akula</style></author><author><style face="normal" font="default" size="100%">Pritpal Singh</style></author><author><style face="normal" font="default" size="100%">Prikshat Kumar Angra</style></author><author><style face="normal" font="default" size="100%">Gagandeep Singh Cheema</style></author><author><style face="normal" font="default" size="100%">Anup Sharma</style></author><author><style face="normal" font="default" size="100%">Mohd Farhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">An Evaluation of the Effectiveness of Pharmacognosy Research and a Pharmaceutical Resource Management in Hospitals</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Data envelopment analysis (DEA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Efficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Hospitals</style></keyword><keyword><style  face="normal" font="default" size="100%">India</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognosy research</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacy</style></keyword><keyword><style  face="normal" font="default" size="100%">SBM model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1224-1229</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This research paper aims to evaluate the relative efficacy of pharmacognosy research on the top 40 tertiary hospitals and its pharmacy in India according to Newsweek's 2021 ranking. &lt;strong&gt;Purpose:&lt;/strong&gt; India's pharmaceutical market is now estimated to be worth $50 billion. India is a significant pharmaceutical exporter, reaching more than 200 nations with its exports. This study will help to identify whether the pharma industry is working efficiently in selected Indian hospitals or not. Thus, to create a bench marking for the hospital pharmacies in India. &lt;strong&gt;Design/methodology/approach:&lt;/strong&gt; Data for the study came from public and private hospitals' official websites, financial records, and government notifications. Cross- sectional data analyses were done using a Slack-Based model and data envelopment analysis (DEA). STATA was the software used to scrutinize the results effectively. &lt;strong&gt;Results: &lt;/strong&gt;Thirteen hospital pharmacies out of a total of 40 are judged to be relatively technically efficient overall, according to the research. The findings of the slack analysis demonstrate that government hospitals and pharmacies are better able to handle slack and effectively manage input and output. &lt;strong&gt;Conclusion: &lt;/strong&gt;The researchers also set upped a benchmarking hospital both for private and government healthcare settings for pharmacognosy research. Thus, it can be utilized for the betterment of the pharmacies.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1224</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Suresh Chandra Akula&lt;sup&gt;1,*&lt;/sup&gt;, Pritpal Singh&lt;sup&gt;1&lt;/sup&gt; , Prikshat Kumar Angra&lt;sup&gt;2&lt;/sup&gt; , Gagandeep Singh Cheema&lt;sup&gt;1&lt;/sup&gt; , Anup Sharma&lt;sup&gt;1&lt;/sup&gt; , Mohd Farhan&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Mittal School of Business, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of computer applications, Lovely Professional University, Phagwara, Punjab 144001, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daya Banyu Bening</style></author><author><style face="normal" font="default" size="100%">Reni Prastyani</style></author><author><style face="normal" font="default" size="100%">Nurwasis</style></author><author><style face="normal" font="default" size="100%">Evelyn Komaratih</style></author><author><style face="normal" font="default" size="100%">Ismi Zuhria</style></author><author><style face="normal" font="default" size="100%">Hari Basuki Notobroto</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">Chrismawan Ardianto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Expressions of Matrix Metalloproteinase-3 and Tissue Inhibitor Metalloproteinase-1 in Corneal Tissue Post Alkali Burn Treated with Topical Medroxyprogesterone Acetate and Doxycycline</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Corneal alkali burn</style></keyword><keyword><style  face="normal" font="default" size="100%">Doxycycline.</style></keyword><keyword><style  face="normal" font="default" size="100%">Medroxyprogesterone acetate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">553-557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;This study aims to investigate the effects of topical Medroxyprogesterone acetate (MPA) and Doxycycline in inhibiting the expression of MMP-3 and TIMP-1 in ocular alkali burn models in animals. &lt;strong&gt;Methods: &lt;/strong&gt;A total of 18 New Zealand Rabbits were divided into 3 groups based on their post-alkali-burn treatment: PBS (G1/ control group), topical Doxycycline 1mg/ml (G2), and topical MPA 1% (G3). Alkali burn models were made by exposing 1N NaOH solution to the central cornea for 30 seconds. MMP-3 and TIMP-1 expression were evaluated using immunohistochemistry after 14 days of treatment. &lt;strong&gt;Results:&lt;/strong&gt;&lt;strong&gt; &lt;/strong&gt;Statistically significant differences in the mean MMP-3 expression were found between the three groups (p=0.010). There was a significant difference in MMP-3 expression between the control group with MPA (p=0.017) and Doxycycline (p=0.028) but was not found between the MPA and Doxycycline groups (p=1,000). The mean differences in TIMP-1 expression between the three treatment groups were statistically significant (p=0.005), with a significant difference between the control group with Doxycycline (p=0.022) and MPA (p=0.007). There was no significant difference in TIMP-1 expression between the Doxycycline and MPA groups (P=1,000). &lt;strong&gt;Conclusion: &lt;/strong&gt;This study indicated that topical administration of Doxycycline or MPA in ocular alkali burn reduces the expression of MMP-3 and TIMP-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">553</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Daya Banyu Bening&lt;sup&gt;1&lt;/sup&gt;, Reni Prastyani&lt;sup&gt;1,*&lt;/sup&gt;, Nurwasis&lt;sup&gt;1&lt;/sup&gt;, Evelyn Komaratih&lt;sup&gt;1&lt;/sup&gt;, Ismi Zuhria&lt;sup&gt;1&lt;/sup&gt;, Hari Basuki Notobroto&lt;sup&gt;2&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;3&lt;/sup&gt;, Chrismawan Ardianto&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Ophthalmology, Dr. Soetomo General Academic Hospital / Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biostatistics and Population, Faculty of Public Health, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sunadi</style></author><author><style face="normal" font="default" size="100%">Saddam Al Aziz</style></author><author><style face="normal" font="default" size="100%">Fadhilah Fitri</style></author><author><style face="normal" font="default" size="100%">Devni Prima Sari</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Rismi Verawati</style></author><author><style face="normal" font="default" size="100%">Nita Yessirita</style></author><author><style face="normal" font="default" size="100%">Oski Illiandri</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Putri Azhari</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatitis E Inhibited by Rosmarinic Acid Extract from Clove Plant (Syzygium Aromaricum) through Computational Analysis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Hepatitis E</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Docking.</style></keyword><keyword><style  face="normal" font="default" size="100%">Rosmarinic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium aromaricum</style></keyword><keyword><style  face="normal" font="default" size="100%">Tyrosine FYN</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">518-523</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to evaluate the potential of Rosmarinic Acid as an inhibitor against Hepatitis E by interacting with the active site of the Tyrosine FYN protein. Computational approaches were employed to predict the molecular interactions between Rosmarinic Acid and Tyrosine FYN. The research methodology involved the use of software such as Pymol, Pyrex, Protein Plus, and the Lepinski Rule. Docking analysis was conducted using Pymol to obtain information about the binding energy between Rosmarinic Acid and Tyrosine FYN. The results of the analysis showed that Rosmarinic Acid exhibited a Binding Affinity of -8.3, -8, and -7.9, indicating a strong affinity towards the target protein. Additionally, Root Mean Square Deviation (RMSD) values of 0, 15.905, and 17.014 were used to assess the stability of the formed protein-ligand complex. Analysis using Protein Plus revealed interactions between Rosmarinic Acid and Tyrosine FYN. Furthermore, analysis using the Lepinski Rule to examine the physicochemical properties of Rosmarinic Acid indicated that the molecule had a mass of 360, 5 hydrogen bond donors, 8 hydrogen bond acceptors, a log P value of 1.76, and a molar reactivity of 89.8. These findings highlight the potential of Rosmarinic Acid as an inhibitor of Hepatitis E through its interaction with the Tyrosine FYN protein, providing a basis for the development of potential new therapies in the treatment of this disease.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">518</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sunadi1, Saddam Al Aziz&lt;sup&gt;2&lt;/sup&gt;, Fadhilah Fitri&lt;sup&gt;3&lt;/sup&gt;, Devni Prima Sari&lt;sup&gt;4&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;5&lt;/sup&gt;, Rismi Verawati&lt;sup&gt;6&lt;/sup&gt;, Nita&amp;nbsp;Yessirita&lt;sup&gt;7&lt;/sup&gt;, Oski Illiandri&lt;sup&gt;8&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;9&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;10&lt;/sup&gt;, Putri Azhari&lt;sup&gt;11&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;6,12,*&lt;/sup&gt;, Viol&amp;nbsp;Dhea Kharisma&lt;sup&gt;13,14&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;15&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;16,17&lt;/sup&gt;, ANM Ansori&lt;sup&gt;13,15&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Agrotechnology Study Program, Faculty of Agriculture, Universitas Tamansiswa, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Mathematics Department, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Statistics Department, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Mathematics Department, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Agricultural Product Technology Study Program, Faculty of Agriculture, Universitas Ekasakti, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biomedicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Environmental and Policy Researcher, Environmental Science Program, Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Radiology, Universitas Awalbros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Agricultural Technology, Faculty of Agricultural Technology, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yusuf Baktir</style></author><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Wihasto Suryaningtyas</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hydrocephalus Mice Model: Choroid Plexus Aquaporin-1 Dynamics Following Cerebrospinal Fluid Drainage</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AQP1</style></keyword><keyword><style  face="normal" font="default" size="100%">Aquaporin 1</style></keyword><keyword><style  face="normal" font="default" size="100%">Choroid plexus</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocephalus.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">891-896</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Aquaporins (AQPs) are a family of membrane proteins that act as channels for water, facilitating its movement across the plasma membrane of cells. Aquaporin1 (AQP1), located in the choroid plexus, is thought to be involved in the process of cerebrospinal fluid (CSF) production. Objective: The objective of this study is to examine the impact of hydrocephalus and cerebrospinal fluid (CSF) drainage on the expression of AQP1 in a mice model of hydrocephalus.&lt;strong&gt; Material and Methods&lt;/strong&gt;: Laboratory experimental study with six groups. Five test groups, one control group, and a rat model of hydrocephalus caused by kaolin were used in the experiment. &lt;strong&gt;Results:&lt;/strong&gt; Hydrocephalus in mice model induced by kaolin, and CSF drainage was performed on the 7&lt;sup&gt;th&lt;/sup&gt; and 14&lt;sup&gt;th&lt;/sup&gt; days group. Immunohistochemical analysis was conducted to examine the presence of AQP1 in the&lt;em&gt; choroid plexus&lt;/em&gt; using microscopes. The findings revealed a noticeable decrease in AQP1 expression levels in the &lt;em&gt;choroid plexus,&lt;/em&gt; which exhibited a semi-quantitative decline in correlation with the duration of hydrocephalus (p = 0.01). This decrease was observed when comparing the normal group with the hydrocephalus groups on the 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt;, and 21st days following induction. However, after cerebrospinal fluid (CSF) drainage, there was a significant increase in AQP1 expression (p &amp;lt; 0.05). &lt;strong&gt;Conclusions: &lt;/strong&gt;This study shows the significant role of AQP1 in CSF production by comparing of AQP1 expression in the&lt;em&gt; choroid plexus &lt;/em&gt;of hydrocephalus mice model, with and without CSF drainage. AQP1 expression experiences downregulation in hydrocephalus mice model and upregulation after CSF drainage.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">891</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yusuf Baktir&lt;sup&gt;1&lt;/sup&gt;, Muhammad Arifin Parenrengi&lt;sup&gt;1,*&lt;/sup&gt;, Wihasto Suryaningtyas&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;2&lt;/sup&gt;, I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology Anatomy, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Science, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Fauzan Jauhari</style></author><author><style face="normal" font="default" size="100%">Lucia Yovita Hendrati</style></author><author><style face="normal" font="default" size="100%">Agus Turchan</style></author><author><style face="normal" font="default" size="100%">Asra Al Fauzi</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author><author><style face="normal" font="default" size="100%">Eko Agus Subagio</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Impact of Kaempferia galanga L. Extract on Nerve Growth  Factor Expression in A Rat Model of Traumatic Brain Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">kaempferia galanga</style></keyword><keyword><style  face="normal" font="default" size="100%">Nerve Growth Factor</style></keyword><keyword><style  face="normal" font="default" size="100%">Traumatic Brain Injury</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1236-1243</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Head injuries contribute significantly to morbidity and mortality globally, and there is need of effective treatment. This study focuses on evaluating NGF (Nerve Growth Factor) expression in a rat model of traumatic brain injury, exploring the potential therapeutic effects of &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract. &lt;strong&gt;Methods: &lt;/strong&gt;Male Wistar rats were used in the experiment, and traumatic brain injury was induced using Marmarou's weight drop model. Four groups of rats were studied: a negative control group, a group with traumatic brain injury without &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract, and two groups with traumatic brain injury treated with different doses of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. Rats were divided further based on the time of decapitation, either 24 or 48 hours post-injury. NGF expression was assessed using immunohistochemistry. &lt;strong&gt;Results:&lt;/strong&gt; The study confirmed NGF expression variations among groups, with stronger expression observed 48 hours post-injury in rats receiving 1200 mg/kgbb of &lt;em&gt;Kaempferia galanga L.&lt;/em&gt; extract. This suggests a potential impact of the extract on NGF expression, likely attributed to its anti-inflammatory and antioxidant properties. &lt;strong&gt;Discussion:&lt;/strong&gt; &lt;em&gt;Kaempferia galanga L&lt;/em&gt;. extract has known anti-inflammatory and antioxidant effects, which may contribute to increased NGF expression observed in this study. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study sheds light on the potential benefits of&lt;em&gt; Kaempferia galanga L&lt;/em&gt;. extract in promoting NGF expression and improving outcomes in traumatic brain injury, emphasizing the need for further investigation to translate these findings into clinical practice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1236</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Fauzan Jauhari&lt;sup&gt;1&lt;/sup&gt; , Lucia Yovita Hendrati&lt;sup&gt;2 *&lt;/sup&gt;, Agus Turchan&lt;sup&gt;1 &lt;/sup&gt;, Asra Al Fauzi&lt;sup&gt;1&lt;/sup&gt; , Budi Utomo&lt;sup&gt;3&lt;/sup&gt; , Eko Agus Subagio&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Epidemiology, Population Biostatistics and Health promotion, Faculty of Public Health, Universitas Airlangga, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;&lt;strong&gt;3&lt;/strong&gt;&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine Universitas Airlangga, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hammad</style></author><author><style face="normal" font="default" size="100%">Parellangi</style></author><author><style face="normal" font="default" size="100%">Kelana Kusuma Dharma</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Sukri Palutturi</style></author><author><style face="normal" font="default" size="100%">Ainun Sajidah</style></author><author><style face="normal" font="default" size="100%">Naning Kisworo Utami</style></author><author><style face="normal" font="default" size="100%">Khairir Rizani</style></author><author><style face="normal" font="default" size="100%">Reza Fauzan</style></author><author><style face="normal" font="default" size="100%">Heru Santoso Wahito Nugroho</style></author><author><style face="normal" font="default" size="100%">Muhammad Rasyid</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Mediating Role of Perceived Value on the Relationship between  Quality Assurance and Student Satisfaction in Nursing Education</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Nursing education</style></keyword><keyword><style  face="normal" font="default" size="100%">Perceived value</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality assurance</style></keyword><keyword><style  face="normal" font="default" size="100%">Student satisfaction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1121-1125</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to examine the connections between quality assurance, perceived value, and nursing student satisfaction.&lt;strong&gt; Methods:&lt;/strong&gt; A survey was conducted with 200 nursing students in Indonesia. Data on quality assurance, perceived value, and satisfaction was gathered. Partial least squares structural equation modeling (PLS-SEM) was used to assess the measurement and structural models.&lt;strong&gt; Results&lt;/strong&gt;: PLS-SEM showed a significant positive link between quality assurance and perceived value (β=0.239, p=0.002), and between perceived value and satisfaction (β=0.510, p&amp;lt;0.001). However, no direct relationship was found between quality assurance and satisfaction (β=0.042, p=0.571) in the structural model. Perceived value exhibited a mediating role. &lt;strong&gt;Conclusion:&lt;/strong&gt; Enhancing quality assurance in nursing schools is essential for improving students' perceived value, subsequently leading to higher satisfaction levels. However, it's crucial to note that quality alone doesn't directly impact satisfaction. Nursing schools should prioritize both quality assurance and increasing perceived value to maximize student satisfaction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1121</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hammad&lt;sup&gt;1,*&lt;/sup&gt;, Parellangi&lt;sup&gt;2&lt;/sup&gt; , Kelana Kusuma Dharma&lt;sup&gt;3&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;4&lt;/sup&gt; , Sukri Palutturi&lt;sup&gt;5 &lt;/sup&gt;, Ainun Sajidah&lt;sup&gt;6&lt;/sup&gt; , Naning Kisworo Utami&lt;sup&gt;7&lt;/sup&gt; , Khairir Rizani&lt;sup&gt;8&lt;/sup&gt; , Reza Fauzan&lt;sup&gt;9&lt;/sup&gt; , Heru Santoso Wahito Nugroho&lt;sup&gt;10&lt;/sup&gt;, Muhammad Rasyid&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Master in Department of Nursing, Poltekkes Kemenkes Banjarmasin, Kalimantan Selatan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Doctor (Cand) in Department of Nursing, Poltekkes Kemenkes Banjarmasin, Kalimantan Selatan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Doctor in Department of Nursing, Health Polytechnic, Ministry of Health Pontianak, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Professor of Faculty of Public Health, Hasanuddin University Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Professor of Faculty of Public Health, Hasanuddin University Makassar, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;6&lt;/sup&gt;Master in Department of Nursing, Poltekkes Kemenkes Banjarmasin, Kalimantan Selatan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;7&lt;/sup&gt;Master in Department of Dental Health, Poltekkes Kemenkes Banjarmasin, Kalimantan Selatan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;8&lt;/sup&gt;Master in Department of Nursing, Poltekkes Kemenkes Banjarmasin, Kalimantan Selatan, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;9&lt;/sup&gt;Doctor in Polytechnic of Banjarmasin, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;10&lt;/sup&gt;Professor in Department of Nursing, Health Polytechnic, Ministry of Health Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Meilla Dwi Andrestian</style></author><author><style face="normal" font="default" size="100%">Meitria Syahadatina Noor</style></author><author><style face="normal" font="default" size="100%">Resa Ana Dina</style></author><author><style face="normal" font="default" size="100%">Ayunina Rizky Ferdina</style></author><author><style face="normal" font="default" size="100%">Zulfiana Dewi</style></author><author><style face="normal" font="default" size="100%">Niken Widyastuti Hariati</style></author><author><style face="normal" font="default" size="100%">Purnawati Hustina Rachman</style></author><author><style face="normal" font="default" size="100%">Muhammad Irwan Setiawan</style></author><author><style face="normal" font="default" size="100%">Windy Tri Yuana</style></author><author><style face="normal" font="default" size="100%">Ali Khomsan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Qualitative Study on Adolescent Marriage and The Risk of  Stunting in South Kalimantan</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Adolescent marriage</style></keyword><keyword><style  face="normal" font="default" size="100%">Qualitative investigation</style></keyword><keyword><style  face="normal" font="default" size="100%">Stunting</style></keyword><keyword><style  face="normal" font="default" size="100%">Toddler feeding pattern</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1016-1023</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; An exploratory qualitative investigation to determine the causes of adolescent marriage, analyze the effect of early marriage on stunting, and analyze the food patterns of toddlers in adolescent marriage in South Kalimantan, Indonesia.&lt;strong&gt; Method:&lt;/strong&gt; The method used is phenomenology using the FGD system and in-depth interviews. Participants include the FGD informants from the Family Planning Regional Apparatus Organization, the Office of Women's Empowerment and Child Protection and the Office of Religious Affairs from 13 Regencies/ Cities in South Kalimantan. In-depth interview informants were adolescent marriage offenders and their parents, adolescent pregnant women, midwives, integrated health service post cadres, and community leaders each taken from three Regencies/ Cities. &lt;strong&gt;Results: &lt;/strong&gt;There are not many formal adolescent marriages because they have to get a recommendation from the Religious Courts. Adolescent marriages mostly occur through informal marriages. The high rate of early marriage in South Kalimantan Province is caused by culture and weak enforcement of the rules. The incidence of adolescent marriage is caused by promiscuity and information. Meanwhile, adolescent marriage is mostly due to economic motives and limited education facilities in rural areas. Adolescent marriage is not closely related to the incidence of stunting, but low education can be a factor in the inability of parents to provide good parenting, especially feeding pratice. &lt;strong&gt;Conclusions:&lt;/strong&gt; Adolescent marriages appear to be triggered by economic motives and teenagers' desires, as well as driven by economic conditions, social influences, and a lack of encouragement to complete formal education. It was observed that stunting is more common among toddlers with adolescent mothers than toddlers with adult mothers. There is a poor feeding parenting pattern of toddlers with adolescent parents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1016</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Meilla Dwi Andrestian&lt;sup&gt;1,&lt;/sup&gt;*, Meitria Syahadatina Noor&lt;sup&gt;2&lt;/sup&gt; , Resa Ana Dina&lt;sup&gt;3&lt;/sup&gt; , Ayunina Rizky Ferdina&lt;sup&gt;4&lt;/sup&gt; , Zulfiana Dewi&lt;sup&gt;5&lt;/sup&gt; , Niken Widyastuti Hariati&lt;sup&gt;6&lt;/sup&gt; , Purnawati Hustina Rachman&lt;sup&gt;7&lt;/sup&gt; , Muhammad Irwan Setiawan&lt;sup&gt;8&lt;/sup&gt; , Windy Tri Yuana&lt;sup&gt;9&lt;/sup&gt; , Ali Khomsan&lt;sup&gt;10&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;National Research and Innovation Agency, Bogor, West Jawa, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Nutrition, Polytechnic of Health Ministry of Health, Banjarbaru, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Medicine, University of Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;National Research and Innovation Agency, Bogor, West Jawa, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rangki Astiani</style></author><author><style face="normal" font="default" size="100%">Mohamad Sadikin</style></author><author><style face="normal" font="default" size="100%">Aprilita Rinayanti</style></author><author><style face="normal" font="default" size="100%">Wawaimuli Arozal</style></author><author><style face="normal" font="default" size="100%">Ani Retno Prijanti</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Firdayani Firdayani</style></author><author><style face="normal" font="default" size="100%">Piter Piter</style></author><author><style face="normal" font="default" size="100%">Guntoro Halim</style></author><author><style face="normal" font="default" size="100%">Franciscus D. Suyatna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Triterpene Saponin Compounds from Centella asitica as Renin Inhibitor with Pharmacophore Modeling, Molecular Docking and In-vitro Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antihypertensive.</style></keyword><keyword><style  face="normal" font="default" size="100%">Asiaticoside</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">In-vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Madecasoside</style></keyword><keyword><style  face="normal" font="default" size="100%">Renin inhibitor</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">57-63</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Hypertension is a silent killer that causes kidney, heart, and stroke damage if not handled properly. In Indonesia, the prevalence of the population with high blood pressure is 34.11% with women 36.85% higher than men 31.34%, this shows a fairly high value so that special attention is needed on hypertension therapy. It is known that currently there are 6 types of pharmacological therapy for hypertension and one of the newest is the renin inhibitor class (Aliskiren). Indonesia has diverse natural wealth in the form of flora and fauna, with a wealth of more than 30,000 types of medicinal plants with 9500 potential herbal medicines that have not been utilized optimally, with the largest exporter of herbal medicines in the world. &lt;em&gt;Centella asiatica&lt;/em&gt; plants containing triterpenoid saponins have high renin inhibitor activity, namely the content of Asiaticoside and Madecasoside. The research method was carried out &lt;em&gt;in silico&lt;/em&gt; using molecular simulation and &lt;em&gt;in vitro &lt;/em&gt;with fluorometry (328/552 nm) to test the activity of asiaticoside and madecasoside compounds as well as a mixture of asiaticoside and madecasoside in &lt;em&gt;Centella asiatica&lt;/em&gt; plants. This is supported by the docking outcome. The docking results show that madecososide compounds have a gibbs energy close to the positive control aleskiren (-8.356 kcal/mol) and aleskiren (-9.44 kcal/mol). The experiment results showed that the triterpenoid saponin compound (madecassoside) contained an IC value of 0.71, at a concentration of 5 μg/μl, and absorbance of 1.35 A in the first minute. The strongest renin inhibition was Madecasoside compound with a concentration of 5 μg/μl with an average value of fluorescent adsorption and an average percent inhibition of 135% with the best renin inhibition at Madecasoside 5 ug/ul the first minute with absorbance values 1.19 A. Finally, the &lt;em&gt;in silico&lt;/em&gt; result corresponded to the &lt;em&gt;in vitro&lt;/em&gt; experiment. &lt;em&gt;Centella asiatica&lt;/em&gt; plants have renin inhibitor activity as antihypertensive, especially in secondary metabolites of triterpene saponins with pure madecasoside compounds compared with aliskiren as a renin inhibitor. So that the compound madecasoside has renin inhibitor activity as an antihypertensive.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">57</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rangki Astiani&lt;sup&gt;1,3,*&lt;/sup&gt;, Mohamad Sadikin&lt;sup&gt;1,2&lt;/sup&gt;, Aprilita Rinayanti&lt;sup&gt;4&lt;/sup&gt;, Wawaimuli Arozal&lt;sup&gt;1,5&lt;/sup&gt;, Ani Retno Prijanti&lt;sup&gt;1,2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,6,7&lt;/sup&gt;, Firdayani Firdayani&lt;sup&gt;8&lt;/sup&gt;, Piter Piter&lt;sup&gt;3&lt;/sup&gt;, Guntoro Halim&lt;sup&gt;3&lt;/sup&gt;, Franciscus D. Suyatna&lt;sup&gt;1,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia 10320, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology Molecular and Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10320, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Universitas 17 Agustus 1945 Jakarta, Indonesia 14350, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy Faculty of Health Sciences, Universitas Esa Unggul, Jakarta 11510, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Technology Assesment and Application Agency (BPPT), Indonesian Science and Technology Research Center, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anni Faridah</style></author><author><style face="normal" font="default" size="100%">Rismi Verawati</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Musa Ghufron</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Linda Rosalina</style></author><author><style face="normal" font="default" size="100%">Putri Azhari</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study on the Inhibition of Sinensetin Extract from Cat's Whiskers Plant (Orthosiphon aristatus) on ATP Binding Cassette Sub-Family G Member 2 in Uric Acid</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ATP Binding Cassette</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Orthosiphon aristatus</style></keyword><keyword><style  face="normal" font="default" size="100%">Sinensetin</style></keyword><keyword><style  face="normal" font="default" size="100%">Uric Acid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">506-511</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aims to investigate the potential of sinensetin, a compound found in the Cat's Whiskers plant (&lt;em&gt;Orthosiphon aristatus&lt;/em&gt;), as an inhibitor in inhibiting uric acid through its interaction with ATP Binding Cassette Sub-Family G Member 2 (ABCG2). The &lt;em&gt;in-silico &lt;/em&gt;approach was employed using software tools such as Pymol, PyRx, Protein Plus, and Lepinski Rule. The results of molecular docking analysis using PyRx demonstrated significant interactions between sinensetin and ABCG2, with Binding Affinity values of -6.8, -6.6, and -6.6, and RMSD values of 0, 0.785, and 1.379. The analysis using Protein Plus confirmed the interaction between sinensetin and ABCG2, supporting the previous docking findings. Furthermore, the evaluation of pharmacokinetic parameters using the Lepinski Rule of Five revealed that sinensetin meets the criteria as a potential drug compound, with a molecular weight of 372, no hydrogen bond donors, seven hydrogen bond acceptors, a log P value of 3.345, and a molar reactivity of 98.5. This research provides new insights into the development of uric acid therapy through an &lt;em&gt;in-silico &lt;/em&gt;approach, and these findings can serve as a basis for further research involving in vitro and in vivo validation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anni Faridah&lt;sup&gt;1&lt;/sup&gt;, Rismi Verawati&lt;sup&gt;2&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;2&lt;/sup&gt;, Musa Ghufron&lt;sup&gt;3&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;4&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;5&lt;/sup&gt;, Linda Rosalina&lt;sup&gt;6&lt;/sup&gt;, Putri Azhari&lt;sup&gt;7&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;2,8,*&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;9,10&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;11&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;12,13&lt;/sup&gt;, ANM Ansori&lt;sup&gt;9,10,11&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Community Medicine, Faculty of Medicine, Universitas Muhammadiyah Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Radiology, Universitas Awalbros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Makeup and Beauty, Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Agricultural Technology, Faculty of Agricultural Technology, Universitas Andalas, Padang, West Sumatra, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arifia Safira</style></author><author><style face="normal" font="default" size="100%">Cinta Atsa Mahesa Rani</style></author><author><style face="normal" font="default" size="100%">Roro Ayu Puspitasari</style></author><author><style face="normal" font="default" size="100%">Anindyta Kirana Putri Ayuningtyas</style></author><author><style face="normal" font="default" size="100%">Yayang Amru Mahendra</style></author><author><style face="normal" font="default" size="100%">Agus Purnomo</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author><author><style face="normal" font="default" size="100%">Shekhar Chhetri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Amino Acid and Proximate Analysis of Type-1 Collagen from Sea Cucumber and Tilapia-Skin and its Potential Application as Artificial Tendon</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">collagen</style></keyword><keyword><style  face="normal" font="default" size="100%">Key words: Artificial tendon</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine biodiversity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sea cucumber</style></keyword><keyword><style  face="normal" font="default" size="100%">Tilapia-skin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">358-361</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Tendon injury is a medical indication that requires surgical therapy and prolonged recovery. Collagen plays a crucial role in the wound healing process. Collagen maintains homeostasis, interacts with platelets, and enhances cellular components. Most living organisms consist of collagen components as fibrillar proteins. In this study, the potential properties of type-1 collagen from sea cucumber and Tilapia-skin were evaluated depend on proximate analysis, amino acid composition, and moisture-absorption ability. The result showed that Tilapia-skin has a higher protein and fat composition compared to the sea cucumber. In contrast, moisture, ash, and yield composition showed higher for sea cucumber compared to Tilapiaskin. Meanwhile, based on amino acid analysis was revealed that proline, alanine, methionine, isoleucine, leucine, phenylalanine, and lysine were lower on sea cucumber compared to Tilapia-skin. In conclusion, both type-1 collagen material from sea cucumber and Tilapia-skin might be developed as a biomaterial for tendon injury. It is crucial that further studies be carried out to emphasize the potential of biodegradable and bio-replaceable materials using the&lt;em&gt; in vivo &lt;/em&gt;model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">15</style></accession-num><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arifia Safira&lt;sup&gt;1,5&lt;/sup&gt;, Cinta Atsa Mahesa Rani&lt;sup&gt;1,5&lt;/sup&gt;, Roro Ayu Puspitasari&lt;sup&gt;1,5&lt;/sup&gt;, Anindyta Kirana Putri Ayuningtyas&lt;sup&gt;1,5&lt;/sup&gt;, Yayang Amru Mahendra&lt;sup&gt;1,5,&lt;/sup&gt; Agus Purnomo&lt;sup&gt;2&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;3,5&lt;/sup&gt;, Shekhar Chhetri&lt;sup&gt;4&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;1,5,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Veterinary Anatomy, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Physiology and Pharmacology, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Science, College of Natural Resources, Royal University of Bhutan, Lobesa, Punakha, BHUTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Science, School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tiana Milanda</style></author><author><style face="normal" font="default" size="100%">Raden Maya Febriyanti</style></author><author><style face="normal" font="default" size="100%">Arif Satria Wira Kusuma</style></author><author><style face="normal" font="default" size="100%">Ajeng Diantini</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial and Cytotoxic Activity of Selected Raw-Consumed Vegetables in West Java, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Edible plants</style></keyword><keyword><style  face="normal" font="default" size="100%">West Java</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">289-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Raw-consumed vegetables, known as lalapan, is famous among Sundanese community in West Java because of their heath benefits. In the present study, nine selected raw-consumed vegetables, namely &lt;em&gt;Vigna unguiculata, Ocimum tenuiflorum Linn, Psophocarpus tetragonolobus, Etlingera elatior, Abelmoschus esculentus, Oenanthe javanica, Centella asiatica, Pluchea indica&lt;/em&gt; and &lt;em&gt;Pilea trinervia &lt;/em&gt;were screened for their antibacterial and cytotoxic activity. Antibacterial activity test were conducting using disc diffusion method against Serratia marcescens, Escherichia coli, Enterobacter cloacae. Whereas, the cytotoxic activity were examined using WST assay against lung cancer cell line A549. For the antibacterial activity, this study finds that &lt;em&gt;Ocimum tenuiflorum, Etlingera elatior and Pluchea indica&lt;/em&gt; have highest inhibition zone against tested bacteria. Furthemore, the results of the cytotoxicity assay indicated that among the nine plants tested, five plants showed IC&lt;sub&gt;50&lt;/sub&gt; &amp;lt; 20 μg/mL, including &lt;em&gt;Vigna unguiculata, Ocimum tenuiflorum Linn, Etlingera elatior, Centella asiatica&lt;/em&gt; and &lt;em&gt;Pilea trinervia &lt;/em&gt;with the IC&lt;sub&gt;50 &lt;/sub&gt;value 13.71 μg/mL, 7.43 μg/mL, 12.45 μg/mL, 5.51 μg/mL and 18.84 μg/mL respectively.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">289</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tiana Milanda&lt;sup&gt;1&lt;/sup&gt;, Raden Maya Febriyanti&lt;sup&gt;2,*&lt;/sup&gt;, Arif Satria Wira Kusuma&lt;sup&gt;3&lt;/sup&gt;, Ajeng Diantini&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Associate Professor at Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Doctor in the field of Ethnopharmacy and Lecturer at Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;PhD Student in Molecular Bioscience Program Rutgers the State University of New Jersey, United States of America and lecturer at Department of Pharmaceutical Biology, Faculty of Pharmacy, Padjadjaran University, Jatinangor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor in Pharmacology and Clinical Pharmacy at Faculty of Pharmacy, Padjadjaran University, Jatinangor, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Em Sutrisna</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Aris Fitriani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Effect of Nigella sativa L. Seed from Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Pseudomonas aeruginosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus epidermidis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1029-1032</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Nigella sativa &lt;/em&gt;L. was allegedly to has antibacterial effect. The aim of this research is to investigate antibacterial effect of ethanolic extracts of 96% &lt;em&gt;Nigella sativa&lt;/em&gt; L. from Indonesia toward &lt;em&gt;Staphylococcus&lt;/em&gt; aureus, &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and Streptococcus epidermidis. The Antibacterial activity of of &lt;em&gt;Nigella sativa&lt;/em&gt; L toward &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and &lt;em&gt;Streptococcus&lt;/em&gt; &lt;em&gt;epidermidis &lt;/em&gt;using the well method. The 96% ethanolic extract of 12,5; 25;50 and 100% (mg/ml)inhibit growth of &lt;em&gt;Staphylococcus&lt;/em&gt; &lt;em&gt;aureus&lt;/em&gt; (with inhibition zone 11.06; 29.58; 28.22; 30.84 mm respectively) and &lt;em&gt;Streptococcus epidermidis&lt;/em&gt; (20.90; 31.90; 29.93; 33.07 mm respectively). Ethyl acetate fraction of 96% ethanolic extract of &lt;em&gt;Nigella sativa &lt;/em&gt;concentration of 6,25; 12,5; 25;50 and 100% (mg/ml) inhibit growth of &lt;em&gt;Staphylococcus aureus&lt;/em&gt; (12.91; 15.06; 19.19; 37.48; 46.18 mm respectively and Streptococcus epidermidis (19.07; 19.21; 20.22; 21.62; 40.00 mm respectively). Ethanolic 96% extract and ethyl acetate fraction of ethanolic extract of &lt;em&gt;Nigella sativa&lt;/em&gt; have antibacterial effect toward &lt;em&gt;Staphylococcus&lt;/em&gt; aureus and &lt;em&gt;Streptococcus epidermidis invitro.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1029</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Em Sutrisna&lt;sup&gt;1,*&lt;/sup&gt;, Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Aris Fitriani&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Politeknik Kesehatan Semarang, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mustaqim Apriyansa Rahmadhan</style></author><author><style face="normal" font="default" size="100%">Muhammad Arifin Parenrengi</style></author><author><style face="normal" font="default" size="100%">Wihasto Suryaningtyas</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">I Ketut Sudiana</style></author><author><style face="normal" font="default" size="100%">Budi Utomo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Aquaporine 4 Expression on End Feet Astrocyte Before and After Cerebrospinal Fluid Drainage of Hydrocephalus Mice Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AQP4.</style></keyword><keyword><style  face="normal" font="default" size="100%">Aquaporin 4</style></keyword><keyword><style  face="normal" font="default" size="100%">CSF</style></keyword><keyword><style  face="normal" font="default" size="100%">Drainage</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocephalus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1054-1060</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Aquaporin &lt;/em&gt;(AQP) is a family of integral membrane proteins that function as water channels. AQP facilitates the transport of water across the plasma cell membrane. AQP lining the periventricular wall in the presence of edema may impair the function of the AQP to prevent or facilitate proper movement of water. &lt;strong&gt;Result: &lt;/strong&gt;We analyze the effect of hydrocephalus and CSF drainage on the expression levels of aquaporin 4 (AQP4) end feet astrocytes in a hydrocephalus mice model. The test was carried out using a mice model of hydrocephalus induced with kaolin, then CSF drainage was performed on the 7&lt;sup&gt;th&lt;/sup&gt; and 14&lt;sup&gt;th&lt;/sup&gt; day, and compared the levels of AQP4 expression in each group. Data showed an increase in AQP4 excretion levels in astrocyte end feet along with the duration of hydrocephalus (p = 0.001) in comparison between hydrocephalus mice on the 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt;, and 21&lt;sup&gt;st&lt;/sup&gt; days. AQP4 before and after CSF drainage, comparison of the hydrocephalus group on day 21 with the group of mice undergoing CSF drainage (p&amp;lt;0.05). The results showed that the CSF drainage treatment was proven to reduce the level of AQP4. &lt;strong&gt;Conclusion:&lt;/strong&gt; This is the first study to describe immunohistochemical distribution of AQP4 after drainage hydrocephalus model in mice end feet astrocyte. The AQP4 expression and distribution in after drainage hydrocephalus model was comparable 14&lt;sup&gt;th &lt;/sup&gt;and 21&lt;sup&gt;st &lt;/sup&gt;day of hydrocephalus but 7 days after drainage. Larger studies are needed to substantiate the influence of breed and ageing on AQP4 expression after drainage of hydrocephalus model.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1054</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mustaqim Apriyansa Rahmadhan&lt;sup&gt;1&lt;/sup&gt;, Muhammad Arifin Parenrengi&lt;sup&gt;1,*&lt;/sup&gt;, Wihasto Suryaningtyas&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah&lt;sup&gt;2&lt;/sup&gt;, I Ketut Sudiana&lt;sup&gt;2&lt;/sup&gt;, Budi Utomo&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Neurosurgery, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathology Anatomy, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Science, Faculty of Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muthear N Dawood</style></author><author><style face="normal" font="default" size="100%">Shaymaa AH. Jassim</style></author><author><style face="normal" font="default" size="100%">Maab Azmi Fadel</style></author><author><style face="normal" font="default" size="100%">Imad A. Thanoon</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Artificial Sweeteners Perturbed Liver Enzymes in Rat Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Albumin</style></keyword><keyword><style  face="normal" font="default" size="100%">Artificial Sweeteners</style></keyword><keyword><style  face="normal" font="default" size="100%">Bilirubin</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver Enzyme</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">553-557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;In the recent time there has been an increased demand of low-fat or low calorie diet universally. In the mean while the availability of low calorie products has also increased like sugar free drinks, beverages, biscuits, jams and jellies. On contrary to this, some studies suggest that the prolong use of non-nutritive sweeteners alters the homeostasis of glucose and insulin. It results in fluctuation of glucose level in blood and increase in bodyweight. This study intends to evaluate the effect of non-nutritive sweeteners on the liver function test and record the alteration in the levels of ALP, AST and ALT. Seventy rats were divided into seven equal groups, controlled group received distilled water and the rest six were given NNS Sucrose, Stevia, Sucralose, Saccharine Aspartame and Acesulfame-k, respectively. On the evaluation of Alanine aminotransferase ALT, saccharine and aspartame markedly increased the level of ALT from 40U/L to 80 U/L. Both of these NNS have shown the most raised level of Alanine aminotransferase. This represents the stress on the liver associated with the use of NNS and suggests the use to be controlled in humans.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">553</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muthear N Dawood&lt;sup&gt;1,*&lt;/sup&gt;, Shaymaa AH. Jassim&lt;sup&gt;2&lt;/sup&gt;, Maab Azmi Fadel&lt;sup&gt;3&lt;/sup&gt;, Imad A. Thanoon&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, University of Mosul, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;College of Medicine, Ninevah University, Mosul, IRAQ.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;College of Veterinary Medicine, University of Mosul, Mosul, IRAQ. 4College of Medicine, University of Mosul, Mosul, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Etty Hary Kusumastuti</style></author><author><style face="normal" font="default" size="100%">Priangga Adi Wiratama</style></author><author><style face="normal" font="default" size="100%">Grace Ariani</style></author><author><style face="normal" font="default" size="100%">Stephanie Natasha Djuanda</style></author><author><style face="normal" font="default" size="100%">Alphania Rahniayu</style></author><author><style face="normal" font="default" size="100%">Nila Kurniasari</style></author><author><style face="normal" font="default" size="100%">Dyah Fauziah</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author><author><style face="normal" font="default" size="100%">Isnin Anang Marhana</style></author><author><style face="normal" font="default" size="100%">Alfian Nur Rosyid</style></author><author><style face="normal" font="default" size="100%">Dwi Wahyu</style></author><author><style face="normal" font="default" size="100%">Gilang Muhammad Setyo Nugroho</style></author><author><style face="normal" font="default" size="100%">Adhitri Anggoro</style></author><author><style face="normal" font="default" size="100%">I Komang Rusgi Yandi</style></author><author><style face="normal" font="default" size="100%">Bambang Pujo Semedi</style></author><author><style face="normal" font="default" size="100%">Jilientasia Godrace Lilihata</style></author><author><style face="normal" font="default" size="100%">Ummi Maimunah</style></author><author><style face="normal" font="default" size="100%">Supriadi</style></author><author><style face="normal" font="default" size="100%">Achmad Lefi</style></author><author><style face="normal" font="default" size="100%">Lalu Galih Pratama Rinjani</style></author><author><style face="normal" font="default" size="100%">Edi Suyanto</style></author><author><style face="normal" font="default" size="100%">Ricardo Ardian Nugraha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Differences in interleukin-6 and interleukin-17 expression in covid-19 post-mortem lung tissue biopsy compared with noncovid- 19</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biopsy</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-17</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-6</style></keyword><keyword><style  face="normal" font="default" size="100%">Post mortem lung tissue.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">887-892</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; COVID-19 has spread rapidly around the world. It is necessary to study lung tissue of postmortem COVID19 patients to determine the molecular alteration particularly the role of IL-6 and IL-17 in causing fatality. &lt;strong&gt;Objective:&lt;/strong&gt; This study aims to determine the differences in the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients compared to non-COVID-19 patients. This study also aimed to analyze the correlation between the expressions of IL-6 and IL-17 in lung tissue of post-mortem COVID-19 patients. Methods: This research is an observational analytic study with crosssectional approach. The samples were 15 paraffin blocks of post-mortem lung tissue biopsy of COVID-19 patients, and 15 paraffin blocks of inflammatory lung tissue biopsy or surgery of non-COVID-19 patients. IL-6 and IL-17 expressions were evaluated by immunohistochemical procedure. &lt;strong&gt;Result: &lt;/strong&gt;There was a significant difference in the expression of IL-6 in the COVID-19 group and the non-COVID-19 group with a p-value = 0.001 (p &amp;lt; 0.05). There was a significant difference in the expression of IL-17 in the COVID-19 group and the non-COVID-19 group with p-value = 0.001 (p &amp;lt; 0.05). There was a significant correlation between the expressions of IL-6 and IL-17 in the COVID-19 group, with the Spearman coefficient value (rs) of 0.548 with p = 0.034 (p &amp;lt; 0.05).&lt;strong&gt; Conclusion:&lt;/strong&gt; There are differences in the expression of IL-6 and IL-17 between COVID-19 and non-COVID-19 lung tissue. There is a significant correlation between the expressions of IL-6 and IL-17 in post-mortem lung tissue of COVID-19 patients.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><section><style face="normal" font="default" size="100%">887</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Etty Hary Kusumastuti&lt;sup&gt;1,*&lt;/sup&gt;, Priangga Adi Wiratama&lt;sup&gt;1&lt;/sup&gt;, Grace Ariani&lt;sup&gt;1&lt;/sup&gt;, Stephanie Natasha Djuanda&lt;sup&gt;1&lt;/sup&gt;, Alphania Rahniayu&lt;sup&gt;1&lt;/sup&gt;, Nila Kurniasari&lt;sup&gt;1&lt;/sup&gt;, Dyah Fauziah1, Anny Setijo Rahaju&lt;sup&gt;1&lt;/sup&gt;, Isnin Anang Marhana&lt;sup&gt;2&lt;/sup&gt;, Alfian Nur Rosyid&lt;sup&gt;2&lt;/sup&gt;, Dwi Wahyu&lt;sup&gt;2&lt;/sup&gt;, Gilang Muhammad Setyo Nugroho&lt;sup&gt;2&lt;/sup&gt;, Adhitri Anggoro&lt;sup&gt;2&lt;/sup&gt;, I Komang Rusgi Yandi&lt;sup&gt;2&lt;/sup&gt; Bambang Pujo Semedi&lt;sup&gt;3&lt;/sup&gt;, Jilientasia Godrace Lilihata&lt;sup&gt;3&lt;/sup&gt;, Ummi Maimunah&lt;sup&gt;4&lt;/sup&gt;, Supriadi&lt;sup&gt;4&lt;/sup&gt;, Achmad Lefi&lt;sup&gt;5&lt;/sup&gt;, Lalu Galih Pratama Rinjani&lt;sup&gt;5&lt;/sup&gt;, Edi Suyanto&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ardian Nugraha&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Anesthesiology and Reanimation, Faculty of Medicine, Universitas Airlangga University – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Forensics and Medicolegal Medicine, Faculty of Medicine, Universitas Airlangga – Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amung Logam Saputro</style></author><author><style face="normal" font="default" size="100%">Uliy Ba’sin Syadid</style></author><author><style face="normal" font="default" size="100%">Rimayanti</style></author><author><style face="normal" font="default" size="100%">Suherni Susilowati</style></author><author><style face="normal" font="default" size="100%">Ragil Angga Prastiya</style></author><author><style face="normal" font="default" size="100%">Bodhi Agustono</style></author><author><style face="normal" font="default" size="100%">Fauzan Mumtazi</style></author><author><style face="normal" font="default" size="100%">Marifatunnisa’romadhona</style></author><author><style face="normal" font="default" size="100%">Anastasya</style></author><author><style face="normal" font="default" size="100%">Muhammad Riesta Farhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Vitamin C and E Supplementation and Combination of Both in Egg Yolk Tris Diluter on the Quality of Sapera Goat Spermatozoa in the 5 °C Cooling Process</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">5˚C Cooling Process</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality of Spermatozoa</style></keyword><keyword><style  face="normal" font="default" size="100%">Sapera Goat</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin C</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitamin E</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">661-665</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study was aimed to determine the effect of vitamin C, E supplementation and both combination in the egg yolk tris diluent on the quality of Sapera goat spermatozoa in 5˚C cooling process. The samples were fresh semen collected from Sapera goat. It was divided into four different treatment groups. The control treatment or P0 contained semen sample + egg yolk tris diluent, P1 contained semen sample + egg yolk tris diluent + vitamin C 0,9 mg/ml, P2 contained semen sample + egg yolk tris diluent + vitamin E 1 mg/ml, P3 contained semen sample + egg yolk tris diluent + vitamin C 0,9 mg/ml + vitamin E 1 mg/ ml. The least decrease of spermatozoa motility, viability and membrane integrity was found in P3, which was significantly different to P0 (p&amp;lt;0,05). However, P1 and P2 did not show significant difference in the results of motility and viability evaluation (p&amp;gt;0,05). It can be concluded that the combination of vitamin C and E supplementation can be an optimal antioxidants supplement in egg yolk tris diluent on the quality of Sapera goat spermatozoa in 5˚C cooling process.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">661</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amung Logam Saputro&lt;sup&gt;2,5,*&lt;/sup&gt;, Uliy Ba’sin Syadid&lt;sup&gt;1&lt;/sup&gt;, Rimayanti&lt;sup&gt;3&lt;/sup&gt;, Suherni Susilowati&lt;sup&gt;3&lt;/sup&gt;, Ragil Angga Prastiya&lt;sup&gt;3&lt;/sup&gt;, Bodhi Agustono&lt;sup&gt;4&lt;/sup&gt;, Fauzan Mumtazi&lt;sup&gt;2,5,&lt;/sup&gt; Marifatunnisa’romadhona&lt;sup&gt;2,5&lt;/sup&gt;, Anastasya&lt;sup&gt;2,5,&lt;/sup&gt; Muhammad Riesta Farhan&lt;sup&gt;2,5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Bachelor of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Clinic, Department of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Animal Nutrition, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Veterinary Clinic, School of Health and Life Sciences, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SYLVIA RIZKY PRIMA</style></author><author><style face="normal" font="default" size="100%">ELFAHMI</style></author><author><style face="normal" font="default" size="100%">ELIN JULIANTI</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Antibacterial and Antioxidant Activity of Endophytic Fungi Isolated from CAPSICUM ANNUUM L. and ALLIUM CEPA L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Chaetomium globosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Endophytic fungus</style></keyword><keyword><style  face="normal" font="default" size="100%">Onion</style></keyword><keyword><style  face="normal" font="default" size="100%">Red chili</style></keyword><keyword><style  face="normal" font="default" size="100%">Schizophyllum commune</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">329-334</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aims of this study were to identify the endophytic fungi from &lt;em&gt;Capsicum annuum &lt;/em&gt;L. and &lt;em&gt;Allium cepa &lt;/em&gt;L., to determine antioxidant and antimicrobial activity of ethyl acetate extract of endophytic fungi isolated from&lt;em&gt; C. annuum&lt;/em&gt; and &lt;em&gt;A. cepa&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Endophytic fungi was isolated with potato dextrose agar (PDA) from fruits of &lt;em&gt;C. annuumand &lt;/em&gt;bulbs of&lt;em&gt; A. cepa.&lt;/em&gt; Isolate of endophytic fungi was molecular identified to know the species or genus. Cultivation was carried out on rice media, 4 weeks on room temperature and the extraction by maceration using ethyl acetate. Antioxidant activity were tested by DPPH method. While antibacterial activity was tested by disk diffusion methods and microdilution methods.&lt;strong&gt; Results: &lt;/strong&gt;Five isolates of endophytic fungi from red and green fruits of &lt;em&gt;C. annuum&lt;/em&gt; and bulb of &lt;em&gt;A. cepa &lt;/em&gt;have been isolated and the species or the genus have been confirmed. KCM 1 and KCM 2 isolates endophytic fungi from the red fruits of&lt;em&gt; C. annuum &lt;/em&gt;were confirmed as &lt;em&gt;Diaporthe sp&lt;/em&gt; and Chaetomium globosum. The KCH 1 isolate from green fruits of the &lt;em&gt;C. annuum&lt;/em&gt; was confirmed as &lt;em&gt;Trametes hirsuta. &lt;/em&gt;The KBM 1 and KBM 2 isolates from &lt;em&gt;A. cepa&lt;/em&gt; were confirmed as &lt;em&gt;Schizophyllum&lt;/em&gt; commune and &lt;em&gt;Phlebia sp. &lt;/em&gt;The highest antioxidant and antibacterial activity was exposed by ethyl acetate extract of S. commune. &lt;strong&gt;Conclusion: &lt;/strong&gt;Five isolates endophytic fungi from &lt;em&gt;C. annuum&lt;/em&gt; and&lt;em&gt; A. cepa w&lt;/em&gt;ere &lt;em&gt;Diaporthe sp, C. globosum, T. hirsuta, S. commune&lt;/em&gt; and &lt;em&gt;Phlebia sp&lt;/em&gt;. Ethyl acetate extract of &lt;em&gt;S.commune &lt;/em&gt;gave highest antioxidant and antibacterial activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;SYLVIA RIZKY PRIMA&lt;sup&gt;1,2*&lt;/sup&gt;, ELFAHMI&lt;sup&gt;1&lt;/sup&gt;, ELIN JULIANTI&lt;sup&gt;1&lt;/sup&gt;, IRDA FIDRIANNY&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy – Bandung of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, University August 17, 1945 Jakarta, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">EV Ferubko</style></author><author><style face="normal" font="default" size="100%">TD Rendyuk</style></author><author><style face="normal" font="default" size="100%">TD Dargaeva</style></author><author><style face="normal" font="default" size="100%">SM Nikolaev</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Herbal Medicines Intended for Correction of Digestive System Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">128-132</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Purpose:&lt;/strong&gt; Studying the assortment of herbal medicines (HMs) available in the Russian Federation, and generalizing the use experience of them in gastroenterological practice. &lt;strong&gt;Methods:&lt;/strong&gt; Information and analytical.&lt;strong&gt; Results: &lt;/strong&gt;The analysis of the State Register of Medicines Permitted for Use in Medical Practice, as well as foreign and domestic publications from authoritative international databases, has been carried out. The limited range of drugs prescribed for diseases of the digestive system was revealed. The advantages of using complex drugs in comparison with monopreparations are shown. &lt;strong&gt;Conclusion&lt;/strong&gt;: It is necessary to develop new multicomponent HMs of high therapeutic efficacy and low toxicity for prevention and treatment of digestive system diseases.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Herbal medicines, Digestive system diseases, Correction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">128</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;EV Ferubko&lt;sup&gt;1,*&lt;/sup&gt;, TD Rendyuk&lt;sup&gt;2&lt;/sup&gt;, TD Dargaeva&lt;sup&gt;1&lt;/sup&gt;, SM Nikolaev&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;All-Russian Research Institute of medicinal and Aromatic Plants, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sechenov First Moscow State Medical University, Moscow, RUSSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of General and Experimental Biology of the Siberian Branch of the RAS, Ulan-Ude, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Sofiatul Aini</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Rasyadan Taufiq Probojati</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Elsa Yuniarti</style></author><author><style face="normal" font="default" size="100%">Saddam Al Aziz</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Budhi Oktavia</style></author><author><style face="normal" font="default" size="100%">Amalia Putri Lubis</style></author><author><style face="normal" font="default" size="100%">Fajriah Azra</style></author><author><style face="normal" font="default" size="100%">Fadhilah Fitri</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Screening of Bioactive Compounds from Garcinia mangostana L. Against SARS-CoV-2 via Tetra Inhibitors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia mangostana L.</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">SARS-CoV-2</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">575-579</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The global COVID-19 pandemic caused by SARS-CoV-2 has been the resulted of massive human deaths since early 2020. The purpose of this study was to determine the potential of mangosteen (&lt;em&gt;Garcinia mangostana &lt;/em&gt;L.) as an inhibitor of RBD spike, helicase, Mpro, and RdRp activity of SARS-CoV-2 with an&lt;em&gt; in silico &lt;/em&gt;approach. The samples were obtained from PubChem and RCSB PDB. Analysis of the similarity of the drug was carried out with the Swiss ADME on the basis of Lipinski rule of five. Prediction of antivirus probabilities was carried out using PASS Online. Molecular screening was performed using PyRx through molecular docking. Discovery Studio was used for visualization. The bioactive compounds with the highest antiviral potential were indicated with the lowest binding affinity to the targeted proteins RBD spike, helicase, Mpro, and RdRp of SARS-CoV-2. The results indicated that mangiferin has the greatest potential as a potential antiviral. However, more research is required to validate the results of these computational predictions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">575</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Sofiatul Aini&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;2&lt;/sup&gt;, Rasyadan Taufiq Probojati&lt;sup&gt;2,4&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;5&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;6&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;7&lt;/sup&gt;, Elsa Yuniarti&lt;sup&gt;8,9&lt;/sup&gt;, Saddam Al Aziz&lt;sup&gt;8,10&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;8,11&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;8,11&lt;/sup&gt;, Riso Sari Mandeli&lt;sup&gt;8,12&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;8,11&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;8,13&lt;/sup&gt;, Budhi Oktavia&lt;sup&gt;8,14&lt;/sup&gt;, Amalia Putri Lubis&lt;sup&gt;8,14&lt;/sup&gt;, Fajriah Azra&lt;sup&gt;8,14&lt;/sup&gt;, Fadhilah Fitri&lt;sup&gt;8,15&lt;/sup&gt;, ANM Ansori&lt;sup&gt;16&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;17,18,19&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;8,14,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Mathematics and Natural Sciences, State University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department Mathematics Education, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, RUSSIAN FEDERATION&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">N Nerdy</style></author><author><style face="normal" font="default" size="100%">P Lestari</style></author><author><style face="normal" font="default" size="100%">F Fahdi</style></author><author><style face="normal" font="default" size="100%">EDL Putra</style></author><author><style face="normal" font="default" size="100%">SAB Amir</style></author><author><style face="normal" font="default" size="100%">F Yusuf</style></author><author><style face="normal" font="default" size="100%">TK Bakri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Studies of Sesquiterpene Lactones from Vernonia amygdalina Delile on the Expression of EGFR and VEGFR as a New Anticancer Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">91-97</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To assess the inhibition activity of sesquiterpene lactones from&lt;em&gt; Vernonia amygdalina&lt;/em&gt; Delile as a new anticancer potential on the expression of cancer therapeutic target-proteins, namely: epidermal growth factor receptor (EGFR), and vascular endothelial growth factor receptor (VEGFR)&lt;strong&gt;. Methods:&lt;/strong&gt; The in silico screening, target‐based approach (docking) was performed by the Prediction of Activity Spectra for Substances (PASS) website and AutoDock Vina program. The therapeutic cancer target proteins model of EGFR and VEGFR were downloaded from Research Collaboratory for Structural Bioinformatics (RCSB) protein data bank (PDB) with 5HG7 and 4AG8 as their respective codes.&lt;strong&gt; Results&lt;/strong&gt;: The test compounds have anticancer activity as predicted by the Prediction of Activity Spectra for Substances (PASS) website and AutoDock Vina program. The molecular docking analysis of the test compounds showed strong interactions and good inhibition activity with the targeted proteins with a low docking score value predicted by the AutoDock Vina program.&lt;strong&gt; Conclusion:&lt;/strong&gt; The test compounds have the potential to be used in anticancer drugs through the inhibitory qualities of EGFR and VEGFR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; In silico, Sesquiterpene lactones, EGFR, VEGFR, Vernonia amygdalina Delile.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">91</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;N Nerdy&lt;sup&gt;1,*&lt;/sup&gt;, P Lestari&lt;sup&gt;1&lt;/sup&gt;, F Fahdi&lt;sup&gt;1&lt;/sup&gt;, EDL Putra&lt;sup&gt;2&lt;/sup&gt;, SAB Amir&lt;sup&gt;2&lt;/sup&gt;, F Yusuf3, TK Bakri&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Institut Kesehatan Deli Husada Deli Tua, Deli Tua Timur, Deli Tua, Deli Serdang, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Padang Bulan, Medan Baru, Medan, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan Arjuna, Pintubosi, Laguboti, Toba Samosir, Sumatera Utara, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Kopelma Darussalam, Syiah Kuala, Banda Aceh, Aceh, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nala Mawaddani</style></author><author><style face="normal" font="default" size="100%">Ekris Sutiyanti</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Syamsurizal</style></author><author><style face="normal" font="default" size="100%">Bayu Ramadhani Fajri</style></author><author><style face="normal" font="default" size="100%">Muhammad Raffi Ghifari</style></author><author><style face="normal" font="default" size="100%">Muhammad Thoriq Albari</style></author><author><style face="normal" font="default" size="100%">Muhammad Arya Ghifari</style></author><author><style face="normal" font="default" size="100%">Amalia Putri Lubis</style></author><author><style face="normal" font="default" size="100%">Dony Novaliendry</style></author><author><style face="normal" font="default" size="100%">Dwi Hilda Putri</style></author><author><style face="normal" font="default" size="100%">Fadhilah Fitri</style></author><author><style face="normal" font="default" size="100%">Devni Prima Sari</style></author><author><style face="normal" font="default" size="100%">Alexander Patera Nugraha</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In Silico Study of Entry Inhibitor from Moringa oleifera Bioactive Compounds against SARS-CoV-2 Infection</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Active site</style></keyword><keyword><style  face="normal" font="default" size="100%">COVID-19</style></keyword><keyword><style  face="normal" font="default" size="100%">Moringa oleifera</style></keyword><keyword><style  face="normal" font="default" size="100%">Mpro</style></keyword><keyword><style  face="normal" font="default" size="100%">RdRp</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">565-574</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this study is to screen the content of bioactive compounds of &lt;em&gt;Moringa oleifera &lt;/em&gt;and to identify its potential as an antiviral against COVID 19 through an entry inhibitor mechanism using bioinformatics tools. The sample was obtained from PubChem database. Amino acis sequences were obtained from the NCBI. Protein modeling is made through the SWISSMODEL site. The target proteins for this study were SARS-CoV-2 M&lt;sup&gt;pro&lt;/sup&gt; and RdRp. The protein-inhibitory interaction of the drug from &lt;em&gt;M. oleifera&lt;/em&gt; bioactive compounds to SARS-CoV-2 was predicted by molecular docking with PyRx software. The result shows that&lt;em&gt; M. oleifera &lt;/em&gt;was a potential antiviral candidate for SARS-CoV-2 with an entry inhibitor mechanism through a compound, especially quercetin. The RFMS value of both interactions between M&lt;sup&gt;pro &lt;/sup&gt;and quercetion and RdRp with quercetin were not higher than 1.05. This result still needed further research to prove this prediction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">565</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nala Mawaddani&lt;sup&gt;1&lt;/sup&gt;, Ekris Sutiyanti&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;3&lt;/sup&gt;, Dora Dayu Rahma Turista&lt;sup&gt;4&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;5&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;6&lt;/sup&gt;, Syamsurizal&lt;sup&gt;7,8&lt;/sup&gt;, Bayu Ramadhani Fajri&lt;sup&gt;7,9&lt;/sup&gt;, Muhammad Raffi Ghifari&lt;sup&gt;7,10&lt;/sup&gt;, Muhammad Thoriq Albari&lt;sup&gt;7,10&lt;/sup&gt;, Muhammad Arya Ghifari&lt;sup&gt;7,10&lt;/sup&gt;, Amalia Putri Lubis&lt;sup&gt;7,11&lt;/sup&gt;, Dony Novaliendry&lt;sup&gt;7,12&lt;/sup&gt;, Dwi Hilda Putri&lt;sup&gt;7,8&lt;/sup&gt;, Fadhilah Fitri&lt;sup&gt;7&lt;/sup&gt;,&lt;sup&gt;13&lt;/sup&gt;, Devni Prima Sari&lt;sup&gt;7,14&lt;/sup&gt;, Alexander Patera Nugraha&lt;sup&gt;15&lt;/sup&gt;, ANM Ansori&lt;sup&gt;16&lt;/sup&gt; , Maksim Rebezov&lt;sup&gt;17,18,19&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;7,11,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysics Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Information Technology, Dapartement of Electronic, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Department of Information Technology, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Program Study Informatics, Faculty of Engineering, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Department of Statistics, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, INDONESIA. 16Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Scientific Research, K.G. Razumovsky Moscow State University of Technologies and Management (The First Cossack University), Moscow, RUSSIAN FEDERATION&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dennis R.A. Mans</style></author><author><style face="normal" font="default" size="100%">Priscilla Friperson</style></author><author><style face="normal" font="default" size="100%">Meryll Djotaroeno</style></author><author><style face="normal" font="default" size="100%">Vinoj Sewberath Misser</style></author><author><style face="normal" font="default" size="100%">Jennifer Pawirodihardjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Anti-inflammatory and Antioxidant Activities as well as Phytochemical Content of the Fresh Stem Juice from Montrichardia arborescens Schott (Araceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Montrichardia arborescens Schott</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical content</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem juice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">296-304</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Montrichardia arborescens&lt;/em&gt; Schott (Araceae) is traditionally used for treating, among others, inflammatory conditions, but so far without scientific evidence. In this study, the fresh stem juice was assessed for its anti-inflammatory and antioxidant activities and phytochemical content. &lt;strong&gt;Methods:&lt;/strong&gt; The stem juice’s anti-inflammatory activity was evaluated using a heat-induced bovine serum albumin (BSA) denaturation assay and a hypotonicity-induced human erythrocyte membrane lysis assay. Its antioxidant activity was determined by a DPPH free radical-scavenging assay and a FRAP assay. Diclofenac and Trolox were used as reference compounds. Its phytochemical content was qualitatively explored by standard methods. Data (means ± SDs; n ≥ 3) were evaluated for statistically significant differences (p &amp;lt; 0.05) using ANOVA with Bonferroni post hoc adjustments. &lt;strong&gt;Results:&lt;/strong&gt; At ≥ 12.5% (v/v), the stem juice inhibited BSA denaturation by 50%-75% and membrane lysis by roughly 90%. At 0.20-7.0% (v/v), it did not affect BSA denaturation but stabilized membranes by &amp;gt; 50%. The juice scavenged DPPH free radicals at an EC&lt;sub&gt;50 &lt;/sub&gt;of 2.0 ± 0.2% (v/v) and achieved at that dilution an antioxidant power of 2,616 ± 16 μM Fe&lt;sup&gt;2+&lt;/sup&gt; equivalents. All the effects were in the range of those found with diclofenac 50 μg/mL and Trolox 1.0-6.0 μg/mL. The stem juice contained phenolic compounds, flavonoids, tannins, alkaloids, saponins, and glycosides. &lt;strong&gt;Conclusion:&lt;/strong&gt; The &lt;em&gt;M. arborescens s&lt;/em&gt;tem juice exhibited appreciable anti-inflammatory activities that might mainly be associated with the inhibition of the release of inflammatory mediators, along with notable antioxidant activity, which might be attributable to phytochemicals with known anti-inflammatory and antioxidant properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article </style></work-type><accession-num><style face="normal" font="default" size="100%">07</style></accession-num><section><style face="normal" font="default" size="100%">296</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dennis R.A. Mans*, Priscilla Friperson, Meryll Djotaroeno, Vinoj Sewberath Misser, Jennifer Pawirodihardjo&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, SURINAME.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ninik Mudjihartini</style></author><author><style face="normal" font="default" size="100%">Dewi Pratiwi Purba</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Mohammad Sadikin</style></author><author><style face="normal" font="default" size="100%">Sri Widia A. Jusman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Isolation and Characterization of Neuroglobin and The Reducing Enzyme Metneuroglobin (Neuroglobin Fe3+) From Bovine Brain Tissue</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bovine brain tissue</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroglobin</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroglobin absorption spectrum</style></keyword><keyword><style  face="normal" font="default" size="100%">Reductase enzyme</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">504-510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background/Aim:&lt;/strong&gt; The brain uses 20% of the O2 consumed by the body for energy metabolism. In 2000, found a protein that is thought to be a binding O2 in the brain, namely neuroglobin (Ngb). Ngb is a member of the hemoprotein which has a heme group. The iron ion in the haem group can be oxidized, so a reducing enzyme is needed. In this study, the isolation, purification, and characterization of Ngb protein and the reducing enzyme from oxidized neuroglobin (neuroglobin Fe3+) were carried out. &lt;strong&gt;Materials and methods&lt;/strong&gt;: Ngb protein was isolated by fractionation technique using ammonium sulfate 90% saturation, purified by anion exchange chromatography (DEAE Cellulose) and immunoaffinity chromatography, confirmed by SDS-PAGE and Western blot. The metneuroglobin-reducing enzyme was isolated by RIPA lysis buffer, purified by Affi gel blue chromatography, and confirmed by SDS-PAGE.&lt;strong&gt; Results:&lt;/strong&gt; The isolated Ngb obtained has a molecular weight of 17.26 kDa. Spectrum analysis in the wavelength range of 350- 500nm, showed the afternoon peaks of deoxyNgb, oxyNgb, carboxyNgb and metNgb were 415 nm, 405 nm, 405 nm, and 420 nm, respectively. The results of the isolation of the reducing enzymes obtained consisted of 2 parts, namely the matrix-bound eluate (eluate-1) and matrix-bound eluate (eluate-2). SDSPAGE results of eluate-1, eluate-2 and Ngb-free fraction (byproduct of Ngb purification) showed the same 3 bands at a molecular weight of 72.45; 26.84 and 16.33 kDa were suspected as reducing enzymes.&lt;strong&gt; Conclusion: &lt;/strong&gt;The reduction kinetics was tested by reacting the fraction and metNgb and measuring the deoxyNgb uptake formed per unit time. The results of the measurement of the ratio of NgbFe3+ to NgbFe2+ from the free fractions Ngb, eluate-1 and eluate-2, which has the best reducing activity is eluate-1 because it has the best regression value of 0.8769.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">504</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ninik Mudjihartini, Dewi Pratiwi Purba, Fadilah Fadilah, Mohammad Sadikin, Sri Widia A. Jusman&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology Molecular and Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Magister Program in Biomedical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Defri Rizaldy</style></author><author><style face="normal" font="default" size="100%">Nisrina Khairunnisa Ramadhita</style></author><author><style face="normal" font="default" size="100%">Trishna Nadhifa</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Mangosteen (Garcinia mangostana L.): Evaluation of In Vitro Antioxidant Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Branches</style></keyword><keyword><style  face="normal" font="default" size="100%">CUPRAC.</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Mangosteen</style></keyword><keyword><style  face="normal" font="default" size="100%">Rinds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">633-640</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Mangosteen (&lt;em&gt;Garcinia mangostana&lt;/em&gt; L.), is an evergreen of the &lt;em&gt;Guttiferae &lt;/em&gt;family that carries antioxidant activity.&lt;strong&gt; Objective&lt;/strong&gt;s: to examine the antioxidant activity of the leaves, branches and rinds of the mangosteen using DPPH and CUPRAC methods, total phenolic content (TPC) and total flavonoid content (TFC), analyze the correlation between TPC, TFC and antioxidant activity, the correlation between two methods, and found the levels of flavonoid compounds.&lt;strong&gt; Methods:&lt;/strong&gt; Extraction was performed by reflux method using solvents with graded polarity, namely n-hexane, ethyl acetate and ethanol. Determination of antioxidant activity with DPPH and CUPRAC, TPC and TFC were performed by UV-visible spectrophotometer. The correlation between TPC, TFC and antioxidant activity of DPPH and CUPRAC as well as the correlation between two methods were conducted by Pearson’s method. The level of flavonoid compounds was performed by HPLC. &lt;strong&gt;Results:&lt;/strong&gt; Mangosteen leaves, branches and rinds extracts had antioxidant activity of DPPH in the range of 39.920 – 489.708 mg AAE/g and antioxidant activity of CUPRAC in the range of 116.360 – 570.400 mg AAE/g. The highest TPC was given by the ethanol leaves extract (49.525 ± 4.263 g GAE/100 g) and the highest TFC was given by the n-hexane rinds extract (13.859 ± 1.451 g QE/100 g). The ethanol rinds extract contained rutin 0.0327% and kaempferol 0.0049%. &lt;strong&gt;Conclusions:&lt;/strong&gt; TPC and TFC correlated positive and significant with the value of antioxidant activity, except for the n-hexane leaves extract using the DPPH method. The DPPH and CUPRAC methods gave linear results in determining the antioxidant activity of mangosteen extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><accession-num><style face="normal" font="default" size="100%">22</style></accession-num><section><style face="normal" font="default" size="100%">633</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Defri Rizaldy, Nisrina Khairunnisa Ramadhita*, Trishna Nadhifa, Irda Fidrianny&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Pharmaceutical Biology Department, School of Pharmacy, Bandung Institute of Technology, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syeftyan Muhammad Ali Hamami</style></author><author><style face="normal" font="default" size="100%">Michelle Fai</style></author><author><style face="normal" font="default" size="100%">Ahmad Fariduddin Aththar</style></author><author><style face="normal" font="default" size="100%">M Nizam Zulfi Zakaria</style></author><author><style face="normal" font="default" size="100%">Viol Dhea Kharisma</style></author><author><style face="normal" font="default" size="100%">Ahmad Affan Ali Murtadlo</style></author><author><style face="normal" font="default" size="100%">Muhammad Badrut Tamam</style></author><author><style face="normal" font="default" size="100%">Vikash Jakhmola</style></author><author><style face="normal" font="default" size="100%">Muhammad Hermawan Widyananda</style></author><author><style face="normal" font="default" size="100%">Dora Dayu Rahma Turista</style></author><author><style face="normal" font="default" size="100%">Maksim Rebezov</style></author><author><style face="normal" font="default" size="100%">Nikolai Maksimiuk</style></author><author><style face="normal" font="default" size="100%">Nataliya Kulmakova</style></author><author><style face="normal" font="default" size="100%">Evgeniya Latynina</style></author><author><style face="normal" font="default" size="100%">ANM Ansori</style></author><author><style face="normal" font="default" size="100%">Rahadian Zainul</style></author><author><style face="normal" font="default" size="100%">Riso Sari Mandeli</style></author><author><style face="normal" font="default" size="100%">Devi Purnamasari</style></author><author><style face="normal" font="default" size="100%">Oski Illiandri</style></author><author><style face="normal" font="default" size="100%">Khoirun Nisyak</style></author><author><style face="normal" font="default" size="100%">Ernarisa Fitri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nano Transdermal Delivery Potential of Fucoidan from Sargassum sp. (Brown Algae) as Chemoprevention Agent for Breast Cancer Treatment</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Nano transdermal</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum sp. .</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">789-795</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy’s side effects. Fucoidan is an anticancer bioactive compound derived from &lt;em&gt;Sargassum sp&lt;/em&gt;. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from &lt;em&gt;Sargassum sp.&lt;/em&gt; against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and &lt;em&gt;in silico&lt;/em&gt; study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from &lt;em&gt;Sargassum sp&lt;/em&gt;. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">789</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syeftyan Muhammad Ali Hamami&lt;sup&gt;1&lt;/sup&gt;, Michelle Fai&lt;sup&gt;1&lt;/sup&gt;, Ahmad Fariduddin Aththar&lt;sup&gt;1&lt;/sup&gt;, M Nizam Zulfi Zakaria&lt;sup&gt;1&lt;/sup&gt;, Viol Dhea Kharisma&lt;sup&gt;2,3&lt;/sup&gt;, Ahmad Affan Ali Murtadlo&lt;sup&gt;3&lt;/sup&gt;, Muhammad Badrut Tamam&lt;sup&gt;4&lt;/sup&gt;, Vikash Jakhmola&lt;sup&gt;5&lt;/sup&gt;, Muhammad Hermawan Widyananda&lt;sup&gt;1,3,&lt;/sup&gt; Dora Dayu Rahma Turista&lt;sup&gt;6&lt;/sup&gt;, Maksim Rebezov&lt;sup&gt;7,8,9&lt;/sup&gt;, Nikolai Maksimiuk&lt;sup&gt;10&lt;/sup&gt;, Nataliya Kulmakova&lt;sup&gt;11&lt;/sup&gt;, Evgeniya Latynina&lt;sup&gt;11&lt;/sup&gt;, ANM Ansori&lt;sup&gt;12&lt;/sup&gt;, Rahadian Zainul&lt;sup&gt;13,14,*&lt;/sup&gt;, Riso Sari Mandeli &lt;sup&gt;15&lt;/sup&gt;, Devi Purnamasari&lt;sup&gt;16&lt;/sup&gt;, Oski Illiandri&lt;sup&gt;17&lt;/sup&gt;, Khoirun Nisyak&lt;sup&gt;18&lt;/sup&gt;, Ernarisa Fitri&lt;sup&gt;19&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Life Sciences, Universitas Brawijaya, Malang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Biology Education, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;9&lt;/sup&gt;Department of Scientific Research, Russian State Agrarian University Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;10&lt;/sup&gt;Institute of Medical Education, Yaroslav-the-Wise Novgorod State University, Velikiy Novgorod, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;11&lt;/sup&gt;Department of Veterinary Medicine, Russian State Agrarian University - Moscow Timiryazev Agricultural Academy, Moscow, RUSSIAN FEDERATION.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;12&lt;/sup&gt;Professor Nidom Foundation, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;13&lt;/sup&gt;Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;14&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;15&lt;/sup&gt;Environmental Science, Postgraduate Programme, Universitas Negeri Padang, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;16&lt;/sup&gt;Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;17&lt;/sup&gt;Department of Biomedicine, School of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;18&lt;/sup&gt;Department of Pharmacy, Faculty of Public Health, Universitas Anwar Medika, Sidoarjo, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;19&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Andalas, Padang, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">JG Badilla</style></author><author><style face="normal" font="default" size="100%">MLC Fiangaan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic Evaluation and Acute Toxicity Test of the Formulated Tisane Powder of Gallant Soldier (Galinsoga parviflora Cav., Asteraceae) Aerial Parts from Benguet, Philippines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">193-204</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Galinsoga parviflora &lt;/em&gt;is a medicinal plant traditionally used to manage and treat various health conditions though the dearth of its scientific report on its pharmacognostic and safety profile remains. &lt;strong&gt;Objective&lt;/strong&gt;: This study is designed to delineate the pharmacognostic and safety parameters of &lt;em&gt;G. parviflora &lt;/em&gt;to ensure its authenticity, purity, quality, and safety. &lt;strong&gt;Methods&lt;/strong&gt;: Qualitative and quantitative analysis, including physicochemical evaluation, macroscopic and microscopic characterization, phytochemical screening, and acute toxicity test, were carried out to establish the plant’s diagnostic features and safety needed for its identification and standardization. For the Acute toxicity test, male and female rats were orally administered with aqueous extract at a single dose of 2000 mg/kg (n=5/sex) and 5000 mg/kg (n=3/sex). All experimental animals were critically observed individually for overt signs and symptoms of toxicity, behavioral changes, body weight changes, and mortality for 14 days.&lt;strong&gt; Results:&lt;/strong&gt; The physicochemical characterization, macroscopic evaluation, morphometric determination, surface tissue examination, and powder analysis of the intact and powdered drug material revealed key diagnostic features and properties based on the stem, leaf, flower architecture, and pharmaceutical properties. The aqueous extract primarily contains alkaloids, glycosides, flavonoids, saponins, phytosterols, and tannins as its phytoconstituents. During the acute toxicity test, no toxicological response and mortality were observed on both doses.&lt;strong&gt; Conclusion:&lt;/strong&gt; The present study provides vital architectural features and chemical characteristics of G. parviflora essential for establishing pharmacopoeial standards, especially in plantbased medicine. Additionally, the aqueous extract's oral dose of up to 5000 mg/kg is relatively safe as no significant evidence of treatment-related toxicity and mortality is seen.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key Words&lt;/strong&gt;: Acute toxicity, Microscopic, Physicochemical, Phytochemical, Standardization.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">193</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;JG Badilla*, MLC Fiangaan&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, School of Natural Sciences, Saint Louis University, Baguio City, PHILIPPINES.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Arfi Rabbani</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry, Antioxidant Activity and Cytotoxicity Evaluation of Black-White Fungus Auricularia sp. against Breast MCF-7 Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">01-07</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cancer is a non-communicable disease with over 18.1 million new cases and 9.6 million deaths annually according to WHO. Breast cancer is the number two highest count type of cancer trailing behind lung cancer. Treating cancer is expensive and have various side effects. Active components found in plants or fungi that have antioxidant and cytotoxic activity towards cancer cells, could be an alternative for anticancer. One of the fungi that is potentially developed as an anticancer, are the genus of &lt;em&gt;Auricularia sp&lt;/em&gt;. also known as black-white fungus. This study aims to determine the phytochemicals components, antioxidant activity and cytotoxic effect of the &lt;em&gt;Auricularia sp&lt;/em&gt;. towards MCF-7 breast cancer cells. &lt;strong&gt;Methods&lt;/strong&gt;: Dried black-white fungus of&lt;em&gt; Auricularia sp&lt;/em&gt;. grinded into a fine powder. Then, multilevel maceration is done with the n-hexane, ethyl acetate, ethanol as solvents. The extracts of black-white fungus undergo phytochemical screening and thin layer chromatography (TLC), followed by measuring antioxidant and evaluating the cytotoxic activity towards MCF-7 breast cancer cells. &lt;strong&gt;Results&lt;/strong&gt;: black-white fungus of &lt;em&gt;Auricularia sp.&lt;/em&gt; contained secondary metabolites of flavonoids, alkaloids, and triterpenoids and a total of 17 other phytochemical components. Ethyl acetate extract of black-white fungus showed a weak antioxidant activity towards DPPH free radical with IC50 of 215.51 μg/mL and a very active cytotoxic activity on MCF-7 cells with IC&lt;sub&gt;50&lt;/sub&gt; of 0.21 μg/mL. On the other hand, ethanol and n-hexane extracts of black-white fungus are categorized with an active cytotoxic activity on MCF-7 cells with IC&lt;sub&gt;50 &lt;/sub&gt;of 29.28 μg/mL and 50.39 μg/mL, respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;Black-white fungus &lt;em&gt;Auricularia sp&lt;/em&gt;. that had anticancer activity towards breast MCF-7 cells should be considered as an alternative treatment for breast cancer therapy.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Phytochemistry, Antioxidant, Cytotoxicity, Black-white fungus Auricularia sp., MCF-7 cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">01</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,*&lt;/sup&gt;, Arfi Rabbani&lt;sup&gt;3&lt;/sup&gt;, Anton Bahtiar&lt;sup&gt;4&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gumilar Adhi Nugroho</style></author><author><style face="normal" font="default" size="100%">Febrika Wediasari</style></author><author><style face="normal" font="default" size="100%">Zahra Fadhilah</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">ELFAHMI</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Potency of Antidiabetic Effects of the Combination of Syzygium cumini and Andrographis paniculata in Rats with High-Fat Dietand Streptozotocin-Induced Diabetes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Combination</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">406-412</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Andrographis paniculata&lt;/em&gt; (AP) and &lt;em&gt;Syzygium cumini &lt;/em&gt;(SC) are known for their antihyperglycemic effects. However, the combined effects of these plants have not yet been assessed. This study evaluated the oral acute toxicity and&lt;em&gt; in vivo &lt;/em&gt;antihyperglycemic effects of the extract combining AP and SC (SCAP) in rats with high-fat diet- and streptozotocin (STZ)-induced diabetes. Thirteen female DDY mice for toxicity test were divided into three groups and orally administered one dose SCAP (0, 300, or 2000 mg/kg). On day 15, animals were euthanized, their internal organs were observed, and blood samples were collected for clinical biochemistry analyses.&lt;em&gt; In vivo&lt;/em&gt; antihyperglycemic activity was examined in male Sprague- Dawley rats-induced diabetes. Diabetic rats were assigned to once-daily oral treatment with metformin, AP, SC or SCAP for 1 week. Concerning toxicity, SCAP had no effects on liver and kidney and histology of these organs displayed no abnormalities. Blood glucose levels had a tendency to reduce in treatment groups compared with the findings in the diabetic control group. SCAP treatment protected rats against pancreatic damage. These results illustrated that the combined SCAP treatment had beneficial effects on blood glucose levels and pancreatic β-cell function, in rats-induced diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">406</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gumilar Adhi Nugroho&lt;sup&gt;1&lt;/sup&gt;, Febrika Wediasari&lt;sup&gt;1&lt;/sup&gt;, Zahra Fadhilah&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Heri Setiawan&lt;sup&gt;2&lt;/sup&gt;, Elfahmi&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratorium of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, University of Indonesia, Depok, Jawa Barat, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorium of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, Jawa Barat, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Institut Teknologi Bandung, Bandung, Jawa Barat, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Anse Diana Valentiene Messah</style></author><author><style face="normal" font="default" size="100%">Sawitri Darmiati</style></author><author><style face="normal" font="default" size="100%">Cleopas Marthin Rumende</style></author><author><style face="normal" font="default" size="100%">Retno Ariza Soemarwoto</style></author><author><style face="normal" font="default" size="100%">Joedo Prihartono</style></author><author><style face="normal" font="default" size="100%">Asmarinah</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Aisyah Fitriannisa Prawiningrum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Prediction of MMP-9 Polymorphism Impacts on MDR-TB by Molecular Simulation and Network Interaction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gene polymorphism</style></keyword><keyword><style  face="normal" font="default" size="100%">Matrix metalloproteinase 9</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular simulation.</style></keyword><keyword><style  face="normal" font="default" size="100%">Multidrug resistant TB</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">833-841</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;MMP-9 overexpression is associated with a poor outcome in MDR-TB patients, indicating that MMP-9 is a suitable target for MDR-TB therapy. MMP-9 also includes SNPs that occur at inhibitor binding areas as well as zinc ions. As a result of polymorphisms, the usage of MMP-9 inhibitors for MDR-TB might vary. Through molecular simulation, it has been found that the mutant MMP-9 has a larger cavity and a more lipophilic surface. The docking tests revealed that EGTA had the least amount of binding energy to both wild-type and mutant MMP-9. The wildtype MMP-9 can bind zinc when EGTA is in the active site. This shows that using EGTA to chelate Zn is only partially successful. However, the binding energy of EGTA at the active site suggests that it may be a competitor to MMP-9 substrates. On the other hand, Zn is not involved in the interaction of the mutant MMP-9-EGTA complex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">833</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Anse Diana Valentiene Messah&lt;sup&gt;1&lt;/sup&gt;, Sawitri Darmiati&lt;sup&gt;2&lt;/sup&gt;, Cleopas Marthin Rumende&lt;sup&gt;3&lt;/sup&gt;, Retno Ariza Soemarwoto&lt;sup&gt;4&lt;/sup&gt;, Joedo Prihartono&lt;sup&gt;5&lt;/sup&gt;, Asmarinah&lt;sup&gt;1,6,*&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;7,*&lt;/sup&gt;, Aisyah Fitriannisa Prawiningrum&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Radiology, General Hospital Cipto Mangunkusumo, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Internal Medicine Sciences, pulmonology division, Faculty of Medicine, University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pulmonology, General Hospital Abdoel Moelok, Faculty of Medicine University of Lampung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Community Medical Sciences, Faculty University of Indonesia Medicine, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Departement of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Departement of Medical Chemistry, Faculty of Medicine Universitas Indoensia, Jakarta Indonesia.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitria Agustina</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Wimpie Pangkahila</style></author><author><style face="normal" font="default" size="100%">Anak Agung Gde Putra Wiraguna</style></author><author><style face="normal" font="default" size="100%">I Gusti Ayu Sri Mahendra Dewi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of Sericin Sequences from Bombyx mori as Antiaging through ROS with Molecular Simulation and DPPH Evaluation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH.</style></keyword><keyword><style  face="normal" font="default" size="100%">LOX</style></keyword><keyword><style  face="normal" font="default" size="100%">ROS</style></keyword><keyword><style  face="normal" font="default" size="100%">Sericin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">632-641</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The presence of ROS is associated with aging, which is damage caused by free radical reactions. ROS causes oxidation of low density lipoprotein (LDL), which builds up in plaque and contributes to inflammation. With aldehyde secondary products of lipid peroxidation such as Malondialdehyde (MDA), lipoxygenase, and xanthine oxidase as markers of oxidative stress, oxidized LDL causes endothelial dysfunction and cell apoptosis. The antioxidant 1,1 diphenyl-2-picrylhydrazyl (DPPH) sericin from &lt;em&gt;Bombyx mori&lt;/em&gt; was tested &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; in this study. The &lt;em&gt;Bombyx mori&lt;/em&gt; peptide sequences QAYADYHSDPNGGSA (SP4) and ASSSFDASSA (SP7) had lower Gibbs energy for lipooxygenase (LOX) than native ligands, with values of -23.1044, -21.0056, and -10.3275 kcal/mol, respectively. hydrogen bonding to Gln289, Asp293, and Gly569. While ASSSFDASSA (SP7) has a higher Gibbs energy for xanthine oxidase (XOX), SEASSSTQATTVS (SP 5) has a lower Gibbs energy with values of -20.1839, -17.8952, and -11.8921 kcal/mol, respectively. While the cavity binding of the xanthine oxidase peptide binding SP5 and SP7 is located at the Glu802, Asp872, and Ser876 binding sites, the DPPH test confirmed&lt;em&gt; in vitro&lt;/em&gt; that the 10% sericin Gel had an IC50 of 19.7394 ppm compared to 3.71 ppm ascorbic acid. The findings of the preceding study demonstrate that sericin, as an antioxidant, is one of the candidates for antiaging.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">632</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitria Agustina&lt;sup&gt;1,*&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Wimpie Pangkahila&lt;sup&gt;3&lt;/sup&gt;, Anak Agung Gde Putra Wiraguna&lt;sup&gt;4&lt;/sup&gt;, I Gusti Ayu Sri Mahendra Dewi&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Anti-Aging Medicine, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA. Dermatovenereolgist, FitSkinClinic, Bekasi, INDONESIA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Universitas Indonesia, Bioinformatics Core Facilities - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Concentration in Anti-Aging Medicine, Master Program in Biomedical Science, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Dermatology and Venereology Department, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pathology Anatomy Department, Faculty of Medicine, Universitas Udayana, Bali, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Dedy Pratama</style></author><author><style face="normal" font="default" size="100%">Budi Baktijasa Dharmadjati</style></author><author><style face="normal" font="default" size="100%">Muhammad Rafdi Amadis</style></author><author><style face="normal" font="default" size="100%">Ahmad Faisal Dwi Raharja</style></author><author><style face="normal" font="default" size="100%">Muhammad Ramadhan</style></author><author><style face="normal" font="default" size="100%">Dwika Rasyid Firmanda</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Successful Intrapericardial Fibrinolysis on Acute Recurrent Purulent Pericarditis with Impending Cardiac Tamponade during Pandemic Situation: A Rare Case Report</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Intrapericardial fibrinolysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Purulent pericarditis</style></keyword><keyword><style  face="normal" font="default" size="100%">Rare Case Report</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus aureus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1033-1036</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Acute recurrent purulent pericarditis is an uncommon pericardium infection that can be life-threatening due to pus production, leading to cardiac tamponade. &lt;strong&gt;Case presentation:&lt;/strong&gt; We report a 36-year-old man referring to our hospital with impending cardiac tamponade who needed urgent pericardiocentesis. The patient's complaints were worsening dyspnea and palpitations in the last two days. The patient had been hospitalized for the same complaint and had pericardiocentesis due to cardiac tamponade approximately three weeks earlier. Physical exam, ECG, and CXR suggest impending cardiac tamponade. Echocardiography indicated massive right and left pericardial effusion and right atrial collapse. The Covid-19 screening test was positive; however, RT-PCR revealed a negative result. The patient was diagnosed with recurrent acute purulent pericarditis with impending cardiac tamponade requiring urgent pericardiocentesis. After the procedure, 1.5 million units of intrapericardial fibrinolytic were administered to patients. His improved hemodynamic and clinical symptoms indicate a successful procedure. &lt;strong&gt;Conclusion: &lt;/strong&gt;This case highlights the challenges of managing an acute recurrent purulent pericarditis patient due to &lt;em&gt;Staphylococcus A&lt;/em&gt;. infection in the current pandemic era, including distinguishing it from other contagious diseases due to nonspecific dyspnea, limited therapeutic options, and the effectiveness of intrapericardial fibrinolytic in improving the overall patient conditions, and reducing the mortality rate.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1033</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Dedy Pratama, Budi Baktijasa Dharmadjati*, Muhammad Rafdi Amadis, Ahmad Faisal Dwi Raharja, Muhammad Ramadhan, Dwika Rasyid Firmanda&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Cardiology and Vascular Medicine, Airlangga University, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rizqi Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Andi Emelda</style></author><author><style face="normal" font="default" size="100%">Ira Asmaliani</style></author><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Muammar Fawwaz</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Total Phenolic, Flavonoids, and Carotenoids Content and Anti- Obesity Activity of Purslane Herb (Portulaca oleracea L.) Ethanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">08-13</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study aims to determine total flavonoid content (TFC), total phenolic content (TPC), and total carotenoid content (TCC) of ethanolic extract of Purslane (&lt;em&gt;Portulaca oleraceae&lt;/em&gt; L.). &lt;strong&gt;Material and Method&lt;/strong&gt;: Herb of Purslane (&lt;em&gt;Portulaca oleraceae&lt;/em&gt; L.) was extracted using ethanol. Determination of total flavonoid content (TFC), total phenolic content (TPC), and total carotenoid content (TCC) The method used spectrophotometer UV-VIS by the used standard curve to compare the total content by linear regression calculation. &lt;strong&gt;Result:&lt;/strong&gt; The results of this study demonstrated the TPC, TFC, and TCC value was 2.00 mg HE/g DW, 0.53 mg EQ/g DW, 128 mg GAE/g DW, respectively. For anti-obesity, a 200 mg/kg BW sample group had the greatest percentage decrease compared to the other groups (21.868%). &lt;strong&gt;Conclusion&lt;/strong&gt;: This study showed that Purslane is a good source of flavonoids, phenolic, and carotenoids. Meanwhile, the ethanol extract of this plant has prospect potential as anti-obesity.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Anti-obesity activity; Portulaca oleracea L.; Total phenolics, Flavonoids, Carotenoids content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rizqi Nur Azizah&lt;sup&gt;1,*&lt;/sup&gt;, Andi Emelda&lt;sup&gt;1&lt;/sup&gt;, Ira Asmaliani1, Islamudin Ahmad&lt;sup&gt;2&lt;/sup&gt;, Muammar Fawwaz&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Laboratory, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, 90231 South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Research and Development of FARMAKA TROPIS, Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75119 East Kalimantan, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, 90231 South Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kebede Feyisa</style></author><author><style face="normal" font="default" size="100%">Wondu Feyisa</style></author><author><style face="normal" font="default" size="100%">Ture Girma</style></author><author><style face="normal" font="default" size="100%">Teyiba Kemal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Traditional Medicinal Plants Used for the Treatment of Urological and Urogenital Diseases in Ethiopia: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ethiopia.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethnobotany</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Urological diseases</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">722-733</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Ethiopia is recognized as one of the richest biodiversity in Africa. The present review aimed to compile relevant information on medicinal plants traditionally used to manage urogenital diseases in Ethiopia. &lt;strong&gt;Methods:&lt;/strong&gt; Different literatures published specifically on ethnobotanical use of medicinal plants in scientific journals, books, theses and proceedings were reviewed. Data from literatures were analyzed using statistical package for social sciences (SPSS) Version 20 and an Excel spreadsheet and reported using descriptive statistics, frequency, and percentage. &lt;strong&gt;Results&lt;/strong&gt;: A total of 146 medicinal plants are reported in the reviewed literature. It was distributed in 127 genera and 64 families.&lt;em&gt; Cucurbitaceae&lt;/em&gt; (7.51%), Asteriaceae (7.51%), &lt;em&gt;Euphorbaceae&lt;/em&gt; (6.20%) and &lt;em&gt;Apiaceae &lt;/em&gt;(4.80%) were family’s accounts of high number of species. A higher diversity of medicinal plants was reported from Southern nations and nationalities (44.5%), Oromia (41.1%) and Amhara (27.4%) regional states. The most frequently reported growth form of medicinal plants indicated in the review was herbs (46.8%), followed by shrubs (32.6%). Root (36.2%) and leaves (35.3%) were the most used parts. Decoction (26.1%), concoction (16.5%) and pounding (11.9%) were the most frequently reported remedy preparation methods and were administered orally.&lt;strong&gt; Conclusion: &lt;/strong&gt;The present review indicated that urogenital diseases were managed with different medicinal plants throughout the regions of Ethiopian needed scientifically confirmed in order to produce safe and effective drugs from natural products.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><accession-num><style face="normal" font="default" size="100%">32</style></accession-num><section><style face="normal" font="default" size="100%">722</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kebede Feyisa&lt;sup&gt;1,*&lt;/sup&gt;, Wondu Feyisa&lt;sup&gt;2&lt;/sup&gt;, Ture Girma&lt;sup&gt;3&lt;/sup&gt;, Teyiba Kemal&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, ETHIOPIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Midwifery, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, ETHIOPIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biology, College of Natural and Computational Sciences, Dilla University, Dilla, ETHIOPIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, College of Health and Medical Science, Haramaya University, Harar, ETHIOPIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fathul Djannah</style></author><author><style face="normal" font="default" size="100%">Muhammad Nasrum Massi</style></author><author><style face="normal" font="default" size="100%">Mochammad Hatta</style></author><author><style face="normal" font="default" size="100%">Agussalim Bukhari</style></author><author><style face="normal" font="default" size="100%">Irda Handayani</style></author><author><style face="normal" font="default" size="100%">Muhammad Faruk</style></author><author><style face="normal" font="default" size="100%">Anny Setijo Rahaju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Virgin coconut oil and tuberculosis: A mini-review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Mycobacterium tuberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Tuberculosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Virgin coconut oil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">464-469</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Virgin coconut oil is widely promoted and used as healthy and beneficial oil. One of them is caused by antimicrobials. Caprylic, caproic acid, capric acid, lauric acid and tau glyceryl monolaurate are other VCO compositions. Furthermore, due to the non-heating manufacturing process, the content in VCO can reduce cholesterol levels of triglycerides, LDL, phospholipids, VLDL and increase HDL in blood serum. VCO consumption lowers the number of&lt;em&gt; Mycobacterium tuberculosis &lt;/em&gt;colonies while increasing the conversion of BTA sputum. Until now, the prevalence of tuberculosis (TB) disease was extremely high. VCO can be used as a supplement to help TB patients recover faster.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Mini-Review</style></work-type><section><style face="normal" font="default" size="100%">464</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fathul Djannah&lt;sup&gt;1,*&lt;/sup&gt;, Muhammad Nasrum Massi&lt;sup&gt;2&lt;/sup&gt;, Mochammad Hatta&lt;sup&gt;2&lt;/sup&gt;, Agussalim Bukhari&lt;sup&gt;3&lt;/sup&gt;, Irda Handayani&lt;sup&gt;4&lt;/sup&gt;, Muhammad Faruk&lt;sup&gt;5&lt;/sup&gt;, Anny Setijo Rahaju&lt;sup&gt;6,7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Mataram, Mataram, West Nusa Tenggara INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Microbiology, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Nutrition, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Clinical Pathology, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Surgeon, Faculty of Medicine, Universitas Hasanuddin, Makassar South Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universitas Airlangga Academic Hospital, Dr. Soetomo General Academic Hospital, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Liudmyla Zotsenko</style></author><author><style face="normal" font="default" size="100%">Nataliia Nuzhyna</style></author><author><style face="normal" font="default" size="100%">Viktoria Kyslychenko</style></author><author><style face="normal" font="default" size="100%">Oksana Futorna</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anatomical and Ultrastructure Differences Between Some Species of the Genus Elsholtzia Willd. of Flora of Ukraine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Elsholtzia ciliate</style></keyword><keyword><style  face="normal" font="default" size="100%">Elsholtzia stauntonii</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Petal</style></keyword><keyword><style  face="normal" font="default" size="100%">Petiole</style></keyword><keyword><style  face="normal" font="default" size="100%">Stem</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">977-987</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Elsholtzia&lt;/em&gt; species are very popular in Chinese, Tibetan and Vietnamese folk medicine to treat several diseases. Despite the wide range of biological activity and the study of the chemical composition of individual species, the microscopic characteristics of plants of this genus are insufficiently studied. In the article the anatomical structure of two species &lt;em&gt;Elsholtzia &lt;/em&gt;Willd. of flora of Ukraine is represented. The sources of literature provide only a morphological description of &lt;em&gt;Elsholtzia&lt;/em&gt; &lt;em&gt;stauntonii&lt;/em&gt; and &lt;em&gt;Elsholtzia ciliate.&lt;/em&gt; We analyzed crosssections and ultrastructure of leaf blade, petiole, petal and stem, determined their anatomical features, and investigated the ultrastructure of seeds. We have compared the obtained data between this two species of this genus that grow on the territory of Ukraine under similar conditions. &lt;strong&gt;Methods:&lt;/strong&gt; Microscopic analysis was carried out by the well-known methods using the microscope XSP-146TR and ImageJ program. Anatomical structure of &lt;em&gt;Elsholtzia stauntonii&lt;/em&gt; Benth. and&lt;em&gt; Elsholtzia&lt;/em&gt; ciliate Thun. are studied and main diagnostic features are highlighted. The ultrastructure of the surface of the epidermal tissue of leaves, stems and seeds were studied additionally, using scanning microscopy methods. &lt;strong&gt;Results: &lt;/strong&gt;The diagnostic microscopic distinguishing features of &lt;em&gt;E. ciliate &lt;/em&gt;raw material from &lt;em&gt;E. stauntonii &lt;/em&gt;are: the presence of small glandular triсhomes, singly placed on the veins and the presence of long non glandular triсhomes on the central vein of abaxial side. Non glandular triсhomes of &lt;em&gt;E. ciliate &lt;/em&gt;are three times longer compared to another investigated species. The presence of numerous triсhomes and massive clusters of stem sclerenchyma &lt;em&gt;E. stauntonii &lt;/em&gt;can be considered additional taxonomic criteria for comparing the studied species.&lt;strong&gt; Conclusion:&lt;/strong&gt; The practical significance of our research will use to develop of quality control methods for medicinal herbal raw material – «Herba &lt;em&gt;Elsholtziae&lt;/em&gt; Stauntonii», «Herba &lt;em&gt;Elsholtziae &lt;/em&gt;ciliate».&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">977</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Liudmyla Zotsenko&lt;sup&gt;1,&lt;/sup&gt;*, Nataliia Nuzhyna&lt;sup&gt;2&lt;/sup&gt;, Viktoria Kyslychenko&lt;sup&gt;3&lt;/sup&gt;, Oksana Futorna&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;State Laboratory of Quality Control of Medicines, State Institution, Institute of Pharmacology and Toxicology National Academy of Medical Sciences of Ukraine, Kyiv, UKRAINE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;NSC &quot;Institute of Biology and Medicine&quot; Taras Shevchenko National University of Kyiv, Kyiv, UKRAINE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;National University of Pharmacy, Department of Chemistry of Natural Compounds, Kharkiv, UKRAINE.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zahra Fadhilah</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Gumilar Adhi Nugroho</style></author><author><style face="normal" font="default" size="100%">Febrika Wediasari</style></author><author><style face="normal" font="default" size="100%">Eem Masaenah</style></author><author><style face="normal" font="default" size="100%">Varda Arianti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity and Phytochemical Constituents of Syzygium cumini Leave in Kadipaten, Central Java Indonesia, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-hyperglicemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Fasting blood glucose</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzigium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1502-1508</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Ethnomedicaly, jamblang (java plum) has been used as antidiabetic treatment in Dayak Tribe. This study aims to evaluate the effectiveness and the safety of the jamblang leaf extract as an antidiabetic. &lt;strong&gt;Objective: &lt;/strong&gt;Evaluate Effecticity of &lt;em&gt;Syzigium cumini&lt;/em&gt; (java plum) as anti-diabetic herb. &lt;strong&gt;Method&lt;/strong&gt;: The antidiabetic activity test, used an animal model which gaven food a high fat diet High Fat Diet (HFD) then it was induced with Streptozotocin injected intraperitoneally. The subjects used in the study were male rats (&lt;em&gt;Ratus novergicus&lt;/em&gt;) Sprague-Dawley strain. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of jamblang extract has anti hyperglycemic activity through decrease of fasting blood glucose point significantly (dose 1, 50mg/ Kg Bw p: &amp;lt;0.0001, dose 2, 100 mg/Kg BW p: &amp;lt;0.0001).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1502</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Zahra Fadhilah, Berna Elya*, Heri Setiawan, Gumilar Adhi Nugroho, Febrika Wediasari, Eem Masaenah, Varda Arianti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maulana Yusuf Alkandahri</style></author><author><style face="normal" font="default" size="100%">Dani Sujana</style></author><author><style face="normal" font="default" size="100%">Dadang Muhammad Hasyim</style></author><author><style face="normal" font="default" size="100%">Mareetha Zahra Shafirany</style></author><author><style face="normal" font="default" size="100%">Lela Sulastri</style></author><author><style face="normal" font="default" size="100%">Maya Arfania</style></author><author><style face="normal" font="default" size="100%">Dedy Frianto</style></author><author><style face="normal" font="default" size="100%">Farhamzah</style></author><author><style face="normal" font="default" size="100%">Anggun Hari Kusumawati</style></author><author><style face="normal" font="default" size="100%">Nia Yuniarsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic Activity of Extract and Fractions of Castanopsis costata Leaves on Alloxan-induced Diabetic Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Castanopsis costata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus</style></keyword><keyword><style  face="normal" font="default" size="100%">North Sumatra.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1589-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;In North Sumatra, Castanopsis costata is commonly used by traditional practitioners for the treatment of diabetes mellitus, however, no studies have been carried out to substantiate this practice. Therefore, this study aims to evaluate the anti-diabetic activity of extract and fractions of C. costata leaves in mice with alloxan-induced diabetes. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss albino mice with alloxan-induced diabetes, were acquired and subjected to the experimental evaluations. Subsequently, the fasting blood glucose levels of the diabetic mice groups treated with glibenclamid, extract and fractions, as well as the untreated group, were evaluated after two weeks of therapy. &lt;strong&gt;Results: &lt;/strong&gt;Based on the results, the ethanolic extract of C. costata considerably reduced the mice’s blood glucose levels in a dose-dependent manner, at dosages of 25, 50, 100, and 200 mg/kgBW (% DBGL: 21.10%, 46.36%, 58.94%, and 60.93%, respectively). In addition, the water fraction of C. costata leaves produced a greater reduction in blood glucose levels (% DBGL: 78.93%), compared to the ethyl acetate and n-hexane fractions (% DBGL: 67.06% and 58.83%), respectively. Meanwhile, treatment with the antidiabetic drug, glibenclamide (5 mg/kgBW) produced a 50.75% reduction in blood glucose levels. &lt;strong&gt;Conclusion: &lt;/strong&gt;Based on the findings, the extract and fractions of C. costata leaves were concluded to exhibit significant anti-diabetic activity. This supported the claim that traditional practitioners in North Sumatra use the plant extract for diabetes treatment.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1589</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maulana Yusuf Alkandahri&lt;sup&gt;1&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Dani Sujana&lt;sup&gt;2&lt;/sup&gt;, Dadang Muhammad Hasyim&lt;sup&gt;2&lt;/sup&gt;, Mareetha Zahra Shafirany&lt;sup&gt;3&lt;/sup&gt;, Lela Sulastri&lt;sup&gt;4&lt;/sup&gt;, Maya Arfania&lt;sup&gt;1&lt;/sup&gt;, Dedy Frianto&lt;sup&gt;1&lt;/sup&gt;, Farhamzah&lt;sup&gt;1&lt;/sup&gt;, Anggun Hari Kusumawati&lt;sup&gt;1&lt;/sup&gt;, Nia Yuniarsih&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Buana Perjuangan Karawang University, Karawang, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Diploma Program of Pharmacy, Karsa Husada Garut College of Health Sciences, Garut, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutics and Pharmaceutical Technology, School of Pharmacy Muhammadiyah Cirebon, Cirebon, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Justil-Guerrero Hugo Jesús</style></author><author><style face="normal" font="default" size="100%">Chávez-Flores Juana Elvira</style></author><author><style face="normal" font="default" size="100%">Cárdenas-Orihuela Robert Armando</style></author><author><style face="normal" font="default" size="100%">Ramos- Jaco Antonio Guillermo</style></author><author><style face="normal" font="default" size="100%">Ñañez-del-Pino Daniel</style></author><author><style face="normal" font="default" size="100%">Vásquez-Quispe Ángel David</style></author><author><style face="normal" font="default" size="100%">Rojas-Cardenas Nathalie Felicita</style></author><author><style face="normal" font="default" size="100%">Fernández-Flores Nélber</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant Capacity and Protective Effect of Aqueous and Hydroalcoholic Extracts of Senecio rhizomatus Rusby &quot;Llancahuasi&quot; on Erythrocytes Subjected to Oxidative Stress</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoperoxidation</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasma membrane redox system</style></keyword><keyword><style  face="normal" font="default" size="100%">Reactive Oxygen Species</style></keyword><keyword><style  face="normal" font="default" size="100%">Reduced glutathione</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">516-527</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective. &lt;/strong&gt;To evaluate the antioxidant capacity and protective effect of aqueous and hydroalcoholic extracts of &lt;em&gt;Senecio rhizomatus&lt;/em&gt; Rusby in rat erythrocytes subjected to oxidative stress with hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;). &lt;strong&gt;Methodology.&lt;/strong&gt; This study used an experimental design. The extracts were obtained through maceration with 96° ethanol (SeR96), 70° ethanol (SeR70), 50° ethanol (SeR50) and through infused water (SeRAc). Secondary metabolites were identified through colorimetric reactions and precipitation. In each extract, we could determine the capacity to eliminate 2,2-diphenyl-1-picrylhydrazyl radical (DPPH), the reduction of ferric ion and the total polyphenol content. In addition, the activity on the plasma membrane redox system (PMRS) was evaluated in each extract. The protection against oxidative stress in erythrocytes was evaluated by determining the content of reduced glutathione (GSH) and malondialdehyde (MDA). &lt;strong&gt;Results.&lt;/strong&gt; Alkaloids, flavonoids, phenolic compounds, sesquiterpene lactones and sugars were identified in all the extracts. The total polyphenols content showed a correlation with the reduction of ferric ion (r=0.885) and with DPPH radicals elimination (r = -0.899), where the one with the highest antioxidant capacity was SeR50. Thus, the SeR50 (all concentrations) and SeR70 (100 μg/mL concentration) significantly increased the PMRS activity compared to the control group. After inducing oxidative stress in erythrocytes, all the extracts maintained the GSH level and inhibited MDA formation significantly compared to the H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; group. &lt;strong&gt;Conclusion.&lt;/strong&gt; The antioxidant capacity of hydroalcoholic extracts (96°, 70°, 50°) and aqueous infusion of &lt;em&gt;Senecio rhizomatus &lt;/em&gt;Rusby is related to the content of polyphenols. They increase the plasma membrane redox system activity in rat erythrocytes and protect them from oxidative stress induced with H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, showing an increase in the concentration of reduced glutathione and a decrease in malondialdehyde.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">516</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Justil-Guerrero Hugo Jesús&lt;sup&gt;1,&lt;/sup&gt;*, Chávez-Flores Juana Elvira&lt;sup&gt;1&lt;/sup&gt;, Cárdenas-Orihuela Robert Armando&lt;sup&gt;1&lt;/sup&gt;, Ramos-Jaco Antonio Guillermo&lt;sup&gt;1&lt;/sup&gt;, Ñañez-del-Pino Daniel&lt;sup&gt;1&lt;/sup&gt;, Vásquez-Quispe Ángel David&lt;sup&gt;1&lt;/sup&gt;, Rojas-Cardenas Nathalie Felicita&lt;sup&gt;1&lt;/sup&gt;, Fernández-Flores Nélber&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fify I Fathy</style></author><author><style face="normal" font="default" size="100%">Marawan M Shabana</style></author><author><style face="normal" font="default" size="100%">Hoda A Mansour</style></author><author><style face="normal" font="default" size="100%">Manal M Sabry</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Botanical Profile and Phytochemical Evaluation of Leaf, Stem and Root of Egyptian Lycopersicon esculentum Miller</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Lycopersicon esculentum Miller</style></keyword><keyword><style  face="normal" font="default" size="100%">Macro- and micromorphology</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Total phenolics and flavonoids content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1019-1029</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Tomato plant (&lt;em&gt;Lycopersicon esculentum &lt;/em&gt;Miller, Family Solanaceae) is one of the most important vegetables worldwide for its edible fruit. Other plant organs (leaf, stem, and root) are discarded after harvesting. Reports showed that these worthless plant organs are rich untapped sources of biologically active constituents, which encourage us to do further investigation. However, lack of standardization for this plant represented a problem facing their use in medicine.&lt;strong&gt; Objective: &lt;/strong&gt;The objective of the current work is to establish a botanical profile for the leaf, stem, and root, to perform a phytochemical investigation including estimation of the total phenolics and flavonoids content, as well as identification of isolated pure compounds from the highest yield organ. &lt;strong&gt;Methods:&lt;/strong&gt; Samples of each organ have been examined macroscopically and microscopically. A phytochemical investigation including successive extraction, estimation of the total phenolics and flavonoids content were carried out. The different fractions of the leaf, having the highest yield, were subjected to phytochemical investigation using successive columns of silica gel and sephadex. &lt;strong&gt;Results:&lt;/strong&gt; Colorimetric estimation of the total phenolics and flavonoids content showed that the leaf has the highest values (84.29±1.50, 50.49±0.26) followed by the stem (50.94±0.33, 9.10±0.14) then the root (40.71±0.07, 1.32±0.01), respectively. Six known compounds namely: apo- &lt;em&gt;β&lt;/em&gt;-carotenol,&lt;em&gt; β&lt;/em&gt;-sitosterol from the n-hexane fraction, protocatechuic acid, stigmasterol 3-O-&lt;em&gt;β&lt;/em&gt;-D- glucoside from the ethyl acetate fraction, quercetin and rutin from the n-butanol fraction were isolated and their structure elucidation was confirmed by NMR spectroscopy. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study could provide an authenticated data base for this Lycopersicon species.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1019</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fify I. Fathy, Marawan M. Shabana, Hoda A. Mansour, Manal M. Sabry*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nur Haseena Kajahmohideen</style></author><author><style face="normal" font="default" size="100%">Siti NurSyafiqah Razi</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Abdelkader Elbadawy Ashour</style></author><author><style face="normal" font="default" size="100%">Anisa Kusumawardani</style></author><author><style face="normal" font="default" size="100%">Essam A. Makky</style></author><author><style face="normal" font="default" size="100%">OE Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Activity of Eurycoma Longifolia Jack Root Extract Against Nasopharyngeal Carcinoma Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">E. longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Nasopharyngeal carcinoma</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1014-1018</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Eurycoma longifolia &lt;/em&gt;(&lt;em&gt;E. longifolia&lt;/em&gt;) or Tongkat Ali is a tree that grows in southeast Asia, the roots of which contain bioactive components that exhibit cytotoxic properties against various cancer cell lines. However, no study has been conducted to relate the cytotoxic properties against nasopharyngeal carcinoma (NPC), a type of cancer that shows poor prognosis for metastatic disease. The purpose of this study was to determine whether the &lt;em&gt;E. longifolia&lt;/em&gt; root extract exerts cytotoxic activity against nasopharyngeal carcinoma (ORL-115) cell lines. &lt;strong&gt;Materials and Method: &lt;/strong&gt;&lt;em&gt;E. longifolia&lt;/em&gt; root extracts were obtained through Soxhlet extraction method and by using two different solvents; ethanol and dicholoromethane. MTS assay was used to evaluate the cytotoxic effect of the root extracts against ORL-115 cell line for three different incubation time which were 24-hour, 48-hour and 72-hour. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract was significantly more potent compared to DCM extract. Ethanol extract exhibited lower IC&lt;sub&gt;50&lt;/sub&gt; value compared to DCM extract. The IC&lt;sub&gt;50 &lt;/sub&gt;of ethanol extract were 232.1 μg/ml, 66.86 μg/ml and 42.6 μg/ml. Meanwhile the IC&lt;sub&gt;50&lt;/sub&gt; of DCM extract were 678.87 μg/ml, 136.71 μg/ml, 73.72 μg/ml for 24-hour, 48-hour and 72-hour incubation period respectively. The cytotoxic activity of both extracts increased as the incubation time prolonged. The cytotoxic activity of ethanol extract at each incubation time was significantly different from DCM extract except at 72 hours. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;E. longifolia&lt;/em&gt; root extracts exerted cytotoxic activity against the nasopharyngeal carcinoma (ORL-115) cell line. Ethanol extract exhibited lower IC&lt;sub&gt;50&lt;/sub&gt; value compared to DCM extract. The cytotoxic activity of both extracts were dose dependent and time dependent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1014</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nur Haseena Kajahmohideen&lt;sup&gt;1&lt;/sup&gt;, Siti NurSyafiqah Razi&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2,&lt;/sup&gt;*, Abdelkader Elbadawy Ashour&lt;sup&gt;3&lt;/sup&gt;, Anisa Kusumawardani&lt;sup&gt;4&lt;/sup&gt;, Essam A. Makky&lt;sup&gt;5&lt;/sup&gt;, O.E. Ibrahim&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Kulliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer, Department of fundamental dental and medical sciences, Kulliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Lecturer, Basic Medical Science Unit, Kulliyyah of Medicine, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Restorative Dentistry, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Industrial Sciences &amp;amp; Technology, Universiti Malaysia Pahang (UMP), Gambang, 26300 Kuantan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Dentistry, Universiti Teknologi MARA, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Hanifa Nurul Fitri</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity Study of Ethanol Extract of Bintangor Leaf (Calophyllum soulattri Burm.f) on T47D Breast Cancer Cell Line (Cytotoxicity Study with MTT Assay Method)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bintangor Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast Cancer Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Calophyllum soulattri Burm.f</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">362-367</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The public has used Bintangor leaf (&lt;em&gt;Calophyllum soulattr&lt;/em&gt;i Burm.f) for various medical treatments, including treated inflamed eyes and gout. Aim: This research aimed to determine the cytotoxic effect of ethanol extract and fraction of &lt;em&gt;Calophyllum soulattri &lt;/em&gt;Burm. f leaf toward T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. &lt;strong&gt;Methods:&lt;/strong&gt; The test used T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells, the 3-4,5-dimethylthiazol-2yl -2,5-diphenyltetrazolium bromide (MTT) test method, and ELISA Reader to determine the absorbance. This method's principle was the presence of tetrazolium salts by the reductase system in the mitochondria of living cells formed purple formazan crystals. The used parameter was the value of IC&lt;sub&gt;50&lt;/sub&gt;.&lt;strong&gt; Results:&lt;/strong&gt; The result showed that ethanol extract, n-hexane fraction, ethyl acetate fraction, and butanol fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cell. The values of IC&lt;sub&gt;50&lt;/sub&gt; respectively are 585.31 μg/ml; 409.33 μg/ ml; 534.08 μg/ml; and 563.22 μg/ml. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol extract and &lt;em&gt;Calophyllum soulattri&lt;/em&gt; Burm.f leaf fraction did not have a cytotoxic effect on T&lt;sub&gt;47&lt;/sub&gt;D breast cancer cells.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">362</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elidahanum Husni*, Fatma Sri Wahyuni, Hanifa Nurul Fitri, Elsa Badriyya&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Urarat Nanna</style></author><author><style face="normal" font="default" size="100%">Linda Chularojmontri</style></author><author><style face="normal" font="default" size="100%">Pholawat Tingpej</style></author><author><style face="normal" font="default" size="100%">Rawiwun Kaewamatawong</style></author><author><style face="normal" font="default" size="100%">Sudarat Homhual</style></author><author><style face="normal" font="default" size="100%">Wanwisa Suwannaloet</style></author><author><style face="normal" font="default" size="100%">Thanes Fuangfoo</style></author><author><style face="normal" font="default" size="100%">Jarinyaporn Naowaboot</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Aporosa villosa Stem Ethanolic Extract on Adipogenesis in 3T3-L1 Adipocytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aporosa villosa; Adipogenesis; Obesity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1422-1427</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background&lt;/strong&gt;: An excessive fat accumulation is related to development of obesity. Obesity is associated with the induction of insulin resistance and diabetes mellitus conditions. &lt;em&gt;Aporosa villosa &lt;/em&gt;is a plant that found in the Northern and Northeastern region of Thailand.&lt;strong&gt; Objective: &lt;/strong&gt;The present study used 3T3-L1 adipocytes for investigating the effect of &lt;em&gt;Aporosa villosa&lt;/em&gt; stem ethanolic extract (AS) on adipogenesis. &lt;strong&gt;Materials and Methods&lt;/strong&gt;: 3T3-L1 adipocytes were used for measuring the cytotoxicity of AS at a concentration range of 3-100 μg/mL. After adipocyte cells treated with AS (3-100 μg/mL) for 8 days, the lipid accumulation was detected by Oil Red O staining and adipogenic gene expression were determined by quantitative real-time PCR. &lt;strong&gt;Results: &lt;/strong&gt;AS extracts (3-100 μg/mL) did not show cytotoxicity on cell proliferation. After 8 days of treating 3T3-L1 adipocytes with AS at doses of 3, 10, 30 and 100 μg/mL, the lipid droplets were reduced as compared to non-treated cells. Furthermore, the adipogenic genes were measured. The regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα), peroxisome proliferatoractivated receptor γ (PPARγ) and sterol regulatory element binding protein 1c (SREBP1c) were found decreasing in AS extracts. The downstream target genes of these regulators cluster of differentiation (CD) 36, fatty acid synthase (FAS) and lipoprotein lipase (LPL) were also reduced by AS treatments. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings indicate that AS extract has an inhibitory activity on adipogenesis in 3T3-L1 adipocytes via suppressing C/EBPα, PPARγ and SREBP1c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1422</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Urarat Nanna&lt;sup&gt;1&lt;/sup&gt;, Linda Chularojmontri&lt;sup&gt;1&lt;/sup&gt;, Pholawat Tingpej&lt;sup&gt;1&lt;/sup&gt;, Rawiwun Kaewamatawong&lt;sup&gt;2&lt;/sup&gt;, Sudarat Homhual&lt;sup&gt;2&lt;/sup&gt;, Wanwisa Suwannaloet&lt;sup&gt;3&lt;/sup&gt;, Thanes Fuangfoo&lt;sup&gt;4 &lt;/sup&gt;&amp;nbsp;Jarinyaporn Naowaboot&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, Ubon Ratchathani University, Ubon Ratchathani, 34190, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacology, College of Pharmacy, Rangsit University, Pathum Thani 12120, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Iyad bin Ramzi</style></author><author><style face="normal" font="default" size="100%">Muhammad Hazzim bin Kosnin</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author><author><style face="normal" font="default" size="100%">Anisa Kusumawardani</style></author><author><style face="normal" font="default" size="100%">ASM Sabere</style></author><author><style face="normal" font="default" size="100%">Essam A Makky</style></author><author><style face="normal" font="default" size="100%">OE Ibrahim</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author><author><style face="normal" font="default" size="100%">Anisa Kusumawardani</style></author><author><style face="normal" font="default" size="100%">ASM Sabere</style></author><author><style face="normal" font="default" size="100%">Essam A Makky</style></author><author><style face="normal" font="default" size="100%">OE Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Effect of Eurycoma Longifolia Jack (Tongkat Ali) Root Extract on salivary S. Mutans, Lactobacillus and Candida Albicans Isolated from High-Risk Caries Adult Patients</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibition</style></keyword><keyword><style  face="normal" font="default" size="100%">Salivary isolate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">787-791</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Introduction: The roots of &lt;em&gt;E. longifolia jack&lt;/em&gt; (E.L.) or Tongkat Ali have been used in traditional medicine as well as supplements and food additives. Many chemical compounds have been detected in extracts of its roots which are believed to be responsible for its medicinal properties. In this study, our objectives were to study the effects of EL root extracts on the growth of &lt;em&gt;Streptococcus Mutans, Lactobacillus&lt;/em&gt; and &lt;em&gt;Candida Albicans &lt;/em&gt;isolated from saliva of adult patients with high caries risk. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The ethanolic extract of the root of this plant was tested against saliva isolated &lt;em&gt;Streptococcus Mutans, Lactobacillus&lt;/em&gt; and&lt;em&gt; Candida Albicans&lt;/em&gt; via disc diffusion assay at a concentration of 200mg/mL. The minimum inhibitory concentration was carried out by the standard broth microdilution method. Cell viability of test microorganisms against different concentration of the extract and inhibition zones were calculated.&lt;strong&gt; Results:&lt;/strong&gt; Disk diffusion assay showed positive zones of inhibition for all test microorganisms with &lt;em&gt;S. mutans, Lactobacillus &lt;/em&gt;and &lt;em&gt;C. albicans&lt;/em&gt; exhibiting zones of inhibition of 8.3 ± 0.7mm, 12.4 ± 2.4mm and 21.4 ± 2.7mm respectively. For minimum inhibitory concentration, the test microorganisms were tested at concentration of 250mg/ mL, 125mg/mL, 62.5mg/mL, 31.3mg/mL and 0mg/mL. The minimum inhibitory concentration showed that MIC of S. mutans was at 62.5mg/mL, Lactobacillus at 125mg/mL and C. albicans at 31.3mg/mL. Lastly, the cell viability results supported the MIC determined prior. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol-based &lt;em&gt;E.&lt;/em&gt; &lt;em&gt;longifolia Jack&lt;/em&gt; root extract has an antimicrobial effect on the following microorganisms isolated from the saliva of high-risk caries adult patients: &lt;em&gt;S. mutans, Lactobacillus&lt;/em&gt; and &lt;em&gt;C. albicans.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">787</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Iyad bin Ramzi1, Muhammad Hazzim bin Kosnin&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2,&lt;/sup&gt;*, Mohd Hafiz Arzmi&lt;sup&gt;2&lt;/sup&gt;, Anisa Kusumawardani&lt;sup&gt;3&lt;/sup&gt;, ASM Sabere&lt;sup&gt;4&lt;/sup&gt;, Essam A. Makky&lt;sup&gt;5&lt;/sup&gt;, O.E. Ibrahim&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Kuliyyah of Dentistry, International Islamic University Malaysia (IIUM), MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Fundamental Dental and Medical Sciences, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Restorative Dentistry, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Kulliyyah of Pharmacy, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Industrial Sciences &amp;amp; Technology, Universiti Malaysia Pahang (UMP), Gambang, 26300 Kuantan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Faculty of Dentistry, Universiti Teknologi MARA, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mouchira Abdel Salam</style></author><author><style face="normal" font="default" size="100%">Hala M. Raslan</style></author><author><style face="normal" font="default" size="100%">Doha A. Mohamed</style></author><author><style face="normal" font="default" size="100%">Aliaa Elgendy</style></author><author><style face="normal" font="default" size="100%">Rehab A. Hussein</style></author><author><style face="normal" font="default" size="100%">Omneya Moguib</style></author><author><style face="normal" font="default" size="100%">Maha Abdelhadi</style></author><author><style face="normal" font="default" size="100%">Rokia Abd El-Shafy Soliman El-Banna</style></author><author><style face="normal" font="default" size="100%">Karem Fouda</style></author><author><style face="normal" font="default" size="100%">Safenaz Y. El Sherity</style></author><author><style face="normal" font="default" size="100%">Emad N. Zikri</style></author><author><style face="normal" font="default" size="100%">Nagwa M. Ammar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Soybean on Bone Health and Some Metabolic Parameters in Postmenopausal Egyptian Women</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone health</style></keyword><keyword><style  face="normal" font="default" size="100%">Bone mineral density</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypocholesterolemic effect</style></keyword><keyword><style  face="normal" font="default" size="100%">Insulin resistance</style></keyword><keyword><style  face="normal" font="default" size="100%">Metabolic parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Soybean</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">688-697</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Great concern has been raised recently concerning the therapeutic impact of soybean. The present study aims to investigate the effects of soybean on bone health and metabolic parameters in postmenopausal women. &lt;strong&gt;Methods:&lt;/strong&gt; In this clinical study, 72 healthy postmenopausal women aged between 45-65 years were given soybean bioactive fraction 2 capsules (500mg each) daily for 24 weeks. Each capsule contained 31.25 mg proteins, 3.2 mg carbohydrates and 4.84 mg isoflavones. Blood pressure, bone mineral density, plasma osteocalcin (OCN), telopeptides of collagen type I (CTX), fasting insulin and blood glucose, lipid profile, serum creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and TSH were assessed prior and after the period of the study. Insulin resistance was calculated by homeostatic model assessment-IR formula (HOMA-IR). &lt;strong&gt;Results:&lt;/strong&gt; Soy ingestion resulted in a significant increase in T score of the hip and OCN; recording -1.97±0.13/-1.76±0.12 and 22.44±0.60ng/ml/30.93±0.57ng/ml before/after treatment, respectively. A marked decrease was also detected in CTX from 2.22±0.10ng/ml to 1.48±0.08ng/ml. With regard to metabolic parameters, there was a significant decrease in fasting insulin (5.40±0.62uU/ml vs 4.15±0.45uU/ ml), however, fasting glucose and HOMA-IR showed no significant alterations. Lipid profile displayed remarkable decline in total cholesterol (188.86±7.23mg/dl vs 159.60±4.72mg/dl, triglycerides (97.09±5.23mg/dl vs 83.56±4.27mg/dl), LDL-c (75.60±3.06mg/dl vs 63.95±1.86mg/ dl) accompanied with a significant elevation in HDL-c (53.09±0.88 vs 65.81mg/dl±0.80mg/ dl). A significant decrease in both TSH (1.97±0.13 uIU/ml vs 1.40±0.08 uIU/ml) and serum creatinine (0.82±0.02mg/dl vs0.77±0.02mg/dl) was also noticed. &lt;strong&gt;Conclusion:&lt;/strong&gt; Consumption of soy improves bone health, reduces cardiovascular risk with no adverse effects on kidney, liver or thyroid functions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mouchira Abdel Salam&lt;sup&gt;1&lt;/sup&gt;, Hala M. Raslan&lt;sup&gt;2&lt;/sup&gt;, Doha A. Mohamed&lt;sup&gt;3&lt;/sup&gt;, Aliaa Elgendy&lt;sup&gt;1&lt;/sup&gt;, Rehab A. Hussein&lt;sup&gt;4,&lt;/sup&gt;*, Omneya Moguib&lt;sup&gt;2&lt;/sup&gt;, Maha Abdelhadi&lt;sup&gt;2&lt;/sup&gt;, Rokia Abd El- Shafy Soliman El-Banna&lt;sup&gt;5&lt;/sup&gt;, Karem Fouda&lt;sup&gt;3&lt;/sup&gt;, Safenaz Y. El Sherity&lt;sup&gt;5&lt;/sup&gt;, Emad N. Zikri&lt;sup&gt;1&lt;/sup&gt;, Nagwa M. Ammar&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Complementary Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Internal Medicine Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition and Food Sciences Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmacognosy Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Biological Anthropology Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MI Bunu</style></author><author><style face="normal" font="default" size="100%">M I Ikhile</style></author><author><style face="normal" font="default" size="100%">AN Matheri</style></author><author><style face="normal" font="default" size="100%">MT Charlotte</style></author><author><style face="normal" font="default" size="100%">MCD Fotsing</style></author><author><style face="normal" font="default" size="100%">DT Ndinteh</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Secondary Metabolites, Antibacterial, Antiplasmodial and Acute Toxicity Potentials of Chloroform Crude Extract of Boswellia dalzielii Stem Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiplasmodial</style></keyword><keyword><style  face="normal" font="default" size="100%">Boswellia dalzielii</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS RT</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">393-400</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Medicinal plants contain bioactive compounds that have the potentials to cure many human ailments without unnecessary side effects like most of the chemotherapeutic drugs used today. Therefore, the need for phytochemicals in medicinal plants for potentials application in the treatments of these human ailments as alternatives. Drug resistance parasite has rendered most of the drugs used in treating many human diseases ineffective. There is an urgent need and continuous search for new drugs from natural sources because most of the drugs used are either derived from plant or end-product of the natural source. Antibacterial and antiplasmodial activities of &lt;em&gt;Boswellia dalzielii &lt;/em&gt;stem bark chloroform extract against some pathogens and &lt;em&gt;P. bergei&lt;/em&gt; was investigated using the serial dilution method. Phytochemical studies (GC-MS RT profiling) revealed the presence of some secondary metabolites. The extract was tested against thirteen bacterial strains (&lt;em&gt;Styphylococcus epidermidis, Mycobacterium smegmatis, Enterococcus faecalis, Styplococcus aureus, Bacillus subtilis&lt;/em&gt;) and Gram-negative strains &lt;em&gt;Klebsiella aerugninosa, Proteus vulgaris, K. pneumonia, Klebsiella oxytoca,Entrobacter cloacae, Peptostreptococcus asaccharolyticus, Escherichia coli, Proteus mirabilis&lt;/em&gt;). Minimum Inhibitory Concentration (MIC) and the Minimum Bactericidal Concentration (MBC) of the extract showed activities against &lt;em&gt;Mycobacterium smegmatis,Escherichia coli, Klebsiella oxytoca, Klebsiella aerugninosa &lt;/em&gt;and &lt;em&gt;Proteus vulgaris&lt;/em&gt;. The extract demonstrated high safety with LD50 value greater than 5000 mg/kg body weight. The extract shows a high potent of antiplasmodial activities with&lt;em&gt; P. bargie&lt;/em&gt; inhibition of 66.95%. The results demonstrated that &lt;em&gt;Boswelliadalzielii &lt;/em&gt;stem bark extract can be used as a source of cheaper, less toxic novel antibiotic and antimalarial substances for drug development.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">393</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;M.I. Bunu&lt;sup&gt;1&lt;/sup&gt;, M. I.Ikhile&lt;sup&gt;1&lt;/sup&gt;, A.N. Matheri&lt;sup&gt;2&lt;/sup&gt;, M.T. Charlotte&lt;sup&gt;1&lt;/sup&gt;, M.C.D. Fotsing&lt;sup&gt;1&lt;/sup&gt;, D.T. Ndinteh&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical Science, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of chemical Engineering, University of Johannesburg, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dadang Juanda</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author><author><style face="normal" font="default" size="100%">Komar Ruslan Wirasutisna</style></author><author><style face="normal" font="default" size="100%">Muhamad Insanu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Xanthine Oxidase Inhibitory and Antioxidant Activities of Three Organs of Idat (Cratoxylum glaucum Korth.) and Correlation with Phytochemical Cont</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cratoxylum glaucum</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthine oxidase inhibitory</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">971-976</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Idat (&lt;em&gt;Cratoxylum glaucum &lt;/em&gt;Korth.), belonging to the genus Cratoxylum, is known to contain xanthone, quinone, flavonoids, and other phenolic compounds. &lt;strong&gt;Objectives:&lt;/strong&gt; to analyze total phenolic, flavonoid, antioxidant activity, and inhibitory xanthine oxidase activities of leaves, stem, and cortex of idat. &lt;strong&gt;Methods: &lt;/strong&gt;Extraction of leaves, stem, and cortex of idat was carried out by reflux using n-hexane, ethyl acetate, and ethanol as a solvent. Antioxidant activity was tested by the DPPH method and calculated to get the antioxidant activity index (AAI). Determination of total phenolic and flavonoid levels by ultraviolet-visible spectrophotometry.&lt;strong&gt; Results:&lt;/strong&gt; Spectrophotometers measured the inhibitory activity on xanthine oxidase in 96-well plates with allopurinol as standard. Total phenolic and flavonoid content from &lt;em&gt;C. glaucum&lt;/em&gt; extracts varied from 6.62 to 48.77 g GAE/g extract and 1.54 - 25.96 g QE/100 g extract, respectively. The ethanol extracts of leaves, stem, and cortex were very strong antioxidant activity with Antioxidant Activity Index (AAI) values 3.89; 4.55; 10.50, meanwhile AAI of ascorbic acid and quercetin 9.46 and 14.81 respectively. The n-hexane of stem extract had a strong xanthine oxidase inhibitory activity with the IC&lt;sub&gt;50&lt;/sub&gt; was 36.64 μg/ml, while allopurinol was 5.02 μg/ml. &lt;strong&gt;Conclusions: &lt;/strong&gt;Total phenolic content contributed to antioxidant activity. Phenolic compounds in leaves extracts led to the xanthine oxidase inhibitory and antioxidant activities. The extract of &lt;em&gt;C. glaucum&lt;/em&gt; was active as an antioxidant and potentially an inhibitor of xanthine oxidase agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">971</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dadang Juanda&lt;sup&gt;1,2&lt;/sup&gt;, Irda Fidrianny&lt;sup&gt;1&lt;/sup&gt;, Komar Ruslan Wirasutisna&lt;sup&gt;1&lt;/sup&gt;, Muhamad Insanu&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Bhakti Kencana University, Bandung, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Suparmi Suparmi</style></author><author><style face="normal" font="default" size="100%">Minidian Fasitasari</style></author><author><style face="normal" font="default" size="100%">Martanto Martosupono</style></author><author><style face="normal" font="default" size="100%">Jubhar Christian Mangimbulude</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hypoglycemic and Antianemia Effects of Chlorophyll from Sauropus androgynus (L) Merr Leaves in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Chlorophyll</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes mellitus (DM)</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron deficiency anemia (IDA)</style></keyword><keyword><style  face="normal" font="default" size="100%">Sauropus androgynus (L) Merr</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">924-932</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Beneficial effect of katuk (&lt;em&gt;Sauropus androgynus &lt;/em&gt;L Merr) leaves (CSA) as one of medicinal plant in Indonesian jamu may potential to cure diabetes mellitus (DM) and iron deficiency anemia (IDA) as well as its well-known effect to increase breast milk production. &lt;strong&gt;Objectives:&lt;/strong&gt; This study was aiming to explore the hypoglycemic effects of CSA in streptozotocininduced DM rats (STZ) and antianemia effects in IDA rats (FeD). &lt;strong&gt;Material and Methods: &lt;/strong&gt;STZ male Wistar rats were treated with CSA, commercial chlorophyll (Chln) and glibencamide. Blood glucose levels and histological changes of liver, kidney and pancreas were analyzed after 14 days treatment. At separate experiment, FeD female Wistar rats were treated with CSA and Chln. The treatment was performed orally at the 1&lt;sup&gt;st&lt;/sup&gt; - 20&lt;sup&gt;th &lt;/sup&gt;day of pregnancy. Levels of Hb, Fe and ferritin blood serum, number and body weight of the offspring were analyzed on 21st day (post-partum). &lt;strong&gt;Results: &lt;/strong&gt;Treatment of CSA for 14 days to diabetic animals demonstrated the hypoglycemic effect, however the histological analysis suggested that the scores of liver, kidney and pancreas were higher than that in the normal group. Moreover, CSA exerted a significant restorative effect by returning the levels of hemoglobin, serum iron, and serum ferritin. A fetus analysis suggested that the fetus body weight of in the CSA and Chln groups was similar to that in the normal group. &lt;strong&gt;Conclusion: &lt;/strong&gt;CSA treatment are potential as a new herbal supplement to cure DM and IDA. However, the safety dose should be considered to prevent the toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">924</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Suparmi Suparmi&lt;sup&gt;1,&lt;/sup&gt;*, Minidian Fasitasari&lt;sup&gt;2,3&lt;/sup&gt;, Martanto Martosupono&lt;sup&gt;4&lt;/sup&gt;, Jubhar Christian Mangimbulude&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Nutrition, Faculty of Medicine, Universitas Islam Sultan Agung, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Sultan Agung Islamic Hospital, Semarang 50112, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Master Program of Biology, Satya Wacana Christian University, Jl. Diponegoro 52-60 Salatiga 50711, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Afdhila Fitri</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Immunostimulant Activity of Pegagan Embun Herbs Extract (Hydrocotyle sibthorpioides Lam.) With Carbon Clearance Method Towards Male White Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbon clearance</style></keyword><keyword><style  face="normal" font="default" size="100%">Eosinophil</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Immunostimulants</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte</style></keyword><keyword><style  face="normal" font="default" size="100%">Lymphocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Neutrophil</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1472-1477</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;L.) has been used traditionally to cure various diseases such as anti-inflammatory, neutralizing toxins, dysentery, and others. This study aims to determine the immunostimulant effect of pegagan embun herbs extract using the carbon clearance method, the number, and the percentage of leukocyte cells. In this study, 25 male white mice were used, which were divided into five groups, groups 1, 2, and 3 given pegagan embun herbs extract in a dose of 10 mg/kgbw; 50 mg/ kgbw; 200 mg/kgbw, group 4 was given 0,5% Na CMC, and group 5 were given stimuno 50 mg/kgbw. The preparation is given orally for seven consecutive days. On the eighth day, the phagocytosis index, number, and percentage of leukocyte cells were determined. The results showed that pegagan embun herbs extract has immunostimulant activity. The phagocytosis index of the 10 mg/kgbw dose group is 1.0211, 1.27796 for the 50 mg/kgbw, and 1.5250 for the 200 mg/kgbw. Then, the number of leukocytes of the 10, 500, and 200 mg/kgbw are 8.820/μL, 9.906/μL, and 10.790/μL, respectively. The percentage of lymphocyte cells are 58,5%, 60,6% and 62,8%, and for segment neutrophil cells were 26%, 27,6% and 30% for group 10, 50, and 200 mg/kgbw extract. Based on the results, that the pegagan embun herbs extract has immunostimulant activity against male white mice.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1472</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Afriwardi&lt;sup&gt;1&lt;/sup&gt;,*, Afdhila Fitri&lt;sup&gt;2&lt;/sup&gt;, Elidahanum Husni&lt;sup&gt;2&lt;/sup&gt;, Elsa Badriyya&lt;sup&gt;2&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Sukmanadi</style></author><author><style face="normal" font="default" size="100%">Mustofa Helmi Effendi</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Liver-Histological Improvement after Capsaicin Administration in Mice with Aflatoxin B1  oxication</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aflatoxin B1</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsaicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Public health.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1577-1581</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Public health issues are considered to provide safety for public consumption. The distribution of mycotoxins in food is still a concern to be solved. Capsaicin is a property in chili that inhibits the biotransformation of mycotoxins by modifying the activity of liver enzymes in phase I. &lt;strong&gt;Objectives:&lt;/strong&gt; A total of 20 mice were divided into 4 treatment groups, namely (T0) 0.5 ml of polyethylene glycol, (T1) 0.5 ml of capsaicin + 0.5 ml of polyethylene glycol, (T2) 0.1 ml of aflatoxin B1 + 0.5 ml of polyethylene glycol, (T3) 0.1 ml of aflatoxin B1 + 0.5 ml of capsaicin, respectively.&lt;strong&gt; Methods:&lt;/strong&gt; Liver histology was performed with hematoxylin-eosin staining and then evaluated descriptively.&lt;strong&gt; Result: &lt;/strong&gt;The T3 group showed significant improvement in sublobular vein, interlobular vein, centralis vein, interlobular duct. Meanwhile, based on scores of hepatocyte form, focal necrosis, hypertrophy, fibrosis, cholestasis, and steatosis were evaluated for improvement in the T3 group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Capsaicin was revealed to improve the liver histology in mice with aflatoxin B1 toxication.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammad Sukmanadi&lt;sup&gt;1&lt;/sup&gt;, Mustofa Helmi Effendi&lt;sup&gt;2&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;3&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;4&lt;/sup&gt;.&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;SubDivision of Veterinary Pharmacy, Division of Veterinary Basic Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Public Health, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;SubDivision of Veterinary Pharmacology, Division of Veterinary Basic Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Veterinary Anatomy, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mithila Jayasundera</style></author><author><style face="normal" font="default" size="100%">Singarayer Florentine</style></author><author><style face="normal" font="default" size="100%">Kushan U Tennakoon</style></author><author><style face="normal" font="default" size="100%">Bhagirath Singh Chauhan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Value of Three Agricultural Weed Species of the Asteraceae Family: A Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Bidens pilosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacological</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional use</style></keyword><keyword><style  face="normal" font="default" size="100%">Tridax procumbens</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">264-277</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Ageratum conyzoides &lt;/em&gt;L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa&lt;/em&gt; L. are well known plant species of the Asteraceae family that are considered weeds in intensive agriculture. These weeds are traditionally known to have medicinal properties and have been used for therapeutic treatments. However, it is only the lack of proper knowledge, awareness and screening that have limited their use in pharmaceutical sectors. This review attempts to consolidate the traditional, phytochemical and pharmacological studies that have been carried out on &lt;em&gt;Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and&lt;em&gt; Bidens pilosa&lt;/em&gt; L., which we note are widely spread throughout the world. This study was conducted through a coherent search on&lt;em&gt; Ageratum conyzoides&lt;/em&gt; L., &lt;em&gt;Tridax procumbens&lt;/em&gt; L. and &lt;em&gt;Bidens pilosa &lt;/em&gt;L. with respect to traditional uses, phytochemical and pharmacological studies that have been performed on these three agricultural weeds all over the world. An exploration of reported descriptions of the potential medical importance of three agricultural weed species (A&lt;em&gt;. conyzoides, T. procumbens&lt;/em&gt; and &lt;em&gt;B. pilosa&lt;/em&gt;) has been presented. The present review would encourage further clinical investigations into these three plants and their extracts to more closely define the range of uses of these herbs for clinical applications. This, in turn, would give a clear understanding whether these weed species might be targeted to be conserved in a sustainable manner rather than eradicated.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">264</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mithila Jayasundera&lt;sup&gt;1&lt;/sup&gt;, Singarayer Florentine&lt;sup&gt;2,&lt;/sup&gt;*, Kushan U Tennakoon&lt;sup&gt;3&lt;/sup&gt;, Bhagirath Singh Chauhan&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, RMIT University, Bundoora West Campus, Bundoora, VIC 3083, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, Mt Helen Campus, Ballarat, VIC 3353, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Science, Psychology and Sport, Federation University Australia, No.100 Clyde Road, Berwick, VIC 3806, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, Gatton, QLD 4343, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rani Wardani Hakim</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Tri Juli Edi Tarigan</style></author><author><style face="normal" font="default" size="100%">Sri Widia A Jusman</style></author><author><style face="normal" font="default" size="100%">Erni H Purwaningsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Molecular Study of Acalypha indica to Leptin, Alpha Glucosidase, and its Antihyperglycemic Effect on Alpha Glucosidase</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acalypha indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Alpha glucosidase.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiobesity</style></keyword><keyword><style  face="normal" font="default" size="100%">Leptin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1639-1647</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The purpose of this study is to find potential inhibitors of leptin as a proinflammatory adipokine and alpha glucosidase as an enzyme that mediate hyperglycaemia; to alter the chronic complications of obesity from herbal Acalypha indica (Ai). This study was conducted using in silico molecular docking to evaluate the Ai compounds interaction with leptin and alpha glucosidase. The in vitro assay to alpha glucosidase was done to explore antihyperglycemic effect of Ai, as hyperglycaemia is the key process of chronic complication of obesity. &lt;strong&gt;Material and&lt;/strong&gt; &lt;strong&gt;Methods: &lt;/strong&gt;Protein target were leptin and alpha glucosidase; compounds from Ai plant were repundusinic, mauritanin, hesperetin, acaindinin, and glucogalin in pdb format. Molecular docking using autodock vinna. In vitro assay of Ai antihyperglycemic activity was done to alpha glucosidase and was define as IC50 level. &lt;strong&gt;Result:&lt;/strong&gt; The results from the docking analysis demonstrated that compounds from Ai roots contain antihyperglycemic-antiobesity activity which acted by inhibiting leptin and alpha glucosidase receptors. Repundusininc and mauritanin compounds contain hydrogen bond with the greatest leptin enhancer activity on Ser9, Thr35, Glu8, Ser9, Thr25, Gln111, Lys211, Leu7 for repundisinic and Glu8, Thr25, Gly112 and Leu7 for mauritanin. Hesperetin, acaindinin and glucogallin were the most identical compounds with similar affinity binding value to alpha glucosidase. Ai roots was already proven as anti-hyperglycemic-antiobesity which was further confirmed by in vitro assay to alpha glucosidase (IC50 19,429 μg/ml.). &lt;strong&gt;Conclusion:&lt;/strong&gt; The results demonstrated that Ai have anti hyperglycaemic-antiobesity effects and was found to be potentially as antihyperglycemic by in vitro assay to alpha glucosidase.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1639</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rani Wardani Hakim&lt;sup&gt;1,2,6&lt;/sup&gt;,*, Fadilah Fadilah&lt;sup&gt;3,6,7&lt;/sup&gt;, Tri Juli Edi Tarigan&lt;sup&gt;4&lt;/sup&gt;, Sri Widia A Jusman&lt;sup&gt;5&lt;/sup&gt;, Erni H Purwaningsih&lt;sup&gt;2,6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Drug Development and Research Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Bioinformatics Core Facilities, The Indonesian Medical Education and Research Institute, Faculty of Medicine, University of Indonesia, Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arif Nur Muhammad Ansori</style></author><author><style face="normal" font="default" size="100%">Amaq Fadholly</style></author><author><style face="normal" font="default" size="100%">Annise Proboningrat</style></author><author><style face="normal" font="default" size="100%">Yulanda Antonius</style></author><author><style face="normal" font="default" size="100%">Suhailah Hayaza</style></author><author><style face="normal" font="default" size="100%">Raden Joko Kuncoroningrat Susilo</style></author><author><style face="normal" font="default" size="100%">Bilqis Inayatillah</style></author><author><style face="normal" font="default" size="100%">Mada Triandala Sibero</style></author><author><style face="normal" font="default" size="100%">Sin War Naw</style></author><author><style face="normal" font="default" size="100%">Gabrielle Ann Villar Posa</style></author><author><style face="normal" font="default" size="100%">Teguh Hari Sucipto</style></author><author><style face="normal" font="default" size="100%">Soegen Soegijanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Novel Antiviral Investigation of Annona squamosa Leaf Extract against the Dengue Virus Type-2: In vitro Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona squamosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiviral activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DENV-2</style></keyword><keyword><style  face="normal" font="default" size="100%">Vero cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">456-462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dengue virus (DENV) infection is general mosquito-transmitted viral taint. It can lead to the dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Dengue is a solemn illness with no endowed antiviral medication or recognized vaccine. Therefore, we aimed to investigate the activity of &lt;em&gt;Annona squamosa&lt;/em&gt; leaf extract (ASLE) against dengue virus type-2 (DENV-2) isolated from Surabaya, Indonesia in 2013 (NCBI accession number: KT012509). &lt;strong&gt;Methods: &lt;/strong&gt;In this study, the antiviral activity of ASLE was evaluated against DENV- 2 in Vero cells using Viral ToxGlo™ Assay. In addition, we used CellTiter-Glo&lt;sup&gt;®&lt;/sup&gt; Luminescent Cell Viability Assay to set the amount of viable cells in culture based on quantitation of the ATP. &lt;strong&gt;Results: &lt;/strong&gt;DENV-2 replication inhibited by ASLE in Vero cells with IC&lt;sub&gt;50&lt;/sub&gt; = 73.78 μg/mL and SI = 4.49 when cells were treated two days after virus infection, whereas its CC&lt;sub&gt;50&lt;/sub&gt; for cytotoxicity to Vero cells was 331.54 μg/mL. Interestingly, this is the first report on the investigation of ASLE against DENV-2. &lt;strong&gt;Conclusion:&lt;/strong&gt; In summary, ASLE demonstrated the antiviral activity against DENV-2 with less toxicity, and high possibility as a drug candidate. Therefore, it might be suggested for&lt;em&gt; in vivo&lt;/em&gt; assessment in the progress of a potent antiviral against DENV-2.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">456</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Arif Nur Muhammad Ansori&lt;sup&gt;1&lt;/sup&gt;, Amaq Fadholly&lt;sup&gt;1&lt;/sup&gt;, Annise Proboningrat&lt;sup&gt;1&lt;/sup&gt;, Yulanda Antonius&lt;sup&gt;2,&lt;/sup&gt;*, Suhailah Hayaza&lt;sup&gt;3&lt;/sup&gt;, Raden Joko Kuncoroningrat Susilo&lt;sup&gt;3&lt;/sup&gt;, Bilqis Inayatillah&lt;sup&gt;4&lt;/sup&gt;, Mada Triandala Sibero&lt;sup&gt;5&lt;/sup&gt;, Sin War Naw&lt;sup&gt;6&lt;/sup&gt;, Gabrielle Ann Villar Posa&lt;sup&gt;7&lt;/sup&gt;, Teguh Hari Sucipto&lt;sup&gt;8,&lt;/sup&gt;*, Soegeng Soegijanto&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Biotechnology, University of Surabaya, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Doctoral Program in Mathematics and Natural Sciences, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Master Program in Basic Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Chemistry, Myitkyina University, Myitkyina, MYANMAR.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, PHILIPPINES.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author><author><style face="normal" font="default" size="100%">Rika Hartati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacological Activities and Phytochemical Compounds: Overview of Pouteria Genus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pharmacological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical compound</style></keyword><keyword><style  face="normal" font="default" size="100%">Pouteria genus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">577-584</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Species of Pouteria are widely spread in various countries. Pouteria is one of the genus that have diverse pharmacological activities. This review includes an overview of the species from Pouteria, phytochemical methods used in isolation of compounds from Pouteria, and their pharmacological activities. The trends in the pharmacological activity of Pouteria is antioxidant activity, antidiabetic and antimicrobial activities. However, information on its use as a traditional medicine from Pouteria was poor. Chemical compounds that have been widely isolated from Pouteria genus included phenolic acid, other phenolics non flavonoid, flavonoids, and terpenoids derivative. The most widely reported chemical compounds from Pouteria are terpenoid derivatives. Further research is needed for the mechanism of action based on the pharmacological activites of chemical compounds.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">577</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sani Nurlaela Fitriansyah&lt;sup&gt;1,2,&lt;/sup&gt;*, Irda Fidrianny1, Rika Hartati&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, Bandung-40132, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biology, Indonesian School of Pharmacy (Sekolah Tinggi Farmasi Indonesia), Bandung-40226, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhamad Dea Firdaus</style></author><author><style face="normal" font="default" size="100%">Nina Artanti</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Rosmalena</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Constituents and In vitro Antidiabetic and Antioxidant Properties of Various Extracts of Kenikir (Cosmos caudatus) Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">890-895</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (&lt;em&gt;Cosmos caudatus&lt;/em&gt;) &lt;em&gt;kenikir’s &lt;/em&gt;leaves. In previous studies, &lt;em&gt;kenikir's l&lt;/em&gt;eaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of &lt;em&gt;kenikir's&lt;/em&gt; leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various&lt;em&gt; kenikir’s &lt;/em&gt;leave extract. &lt;em&gt;Kenikir’s&lt;/em&gt; leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%. Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p&amp;lt;0.05) and antidiabetic (p&amp;lt;0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of &lt;em&gt;kenikir’s&lt;/em&gt; leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">890</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhamad Dea Firdaus&lt;sup&gt;1&lt;/sup&gt;, Nina Artanti&lt;sup&gt;2&lt;/sup&gt;, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Rosmalena&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok 16424, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, South Tangerang, Banten, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Ikhlas Arsul</style></author><author><style face="normal" font="default" size="100%">Muhamad Insanu</style></author><author><style face="normal" font="default" size="100%">Irda Fidrianny</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry and Pharmacological Activities of Boehmeria Genus: An Update Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological activities</style></keyword><keyword><style  face="normal" font="default" size="100%">Boehmeria</style></keyword><keyword><style  face="normal" font="default" size="100%">Boehmeriasin</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical compound</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1533-1541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Boehmeria is a genus that has the potential to be natural medicine and also has benefit in industry. This genus consists of 82 plants that includes numerous species, subspecies, and varieties. The objective of this review is to provide an overview of chemical and pharmacological characteristics of Boehmeria genus based on research studies. &lt;strong&gt;Methods&lt;/strong&gt;: The reference articles have DOI and were obtained through database from such as Science Direct and PubMed website to ensure their validity and reliable contents. This literature study was made by using minimum 50 literatures from the last 10 years. &lt;strong&gt;Results&lt;/strong&gt;: There are 16 species of Boehmeria genus confirmed to have chemical compounds, and 9 species of which reported to exhibit pharmacological activity in the form of extracts and single compound isolates.&lt;strong&gt; Conclusion: &lt;/strong&gt;Based on this study, it was known that some Boehmeria species contained abundance of Boehmeriasin A, boehmeriasin B, chlorogenic acid, epicatechin, (Z)-9,10,11-trihydroxy-12 octadecenoic acid, catechin, β-sitosterol, rutin, luteolin-7-glucoside, naringin and hesperidin. Boehmeria genus had various activities such as anticancer, anti-inflammatory, antidiabetic, antihyperlipidemic, antimicrobial, antioxidant, and anti-hepatitis B.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1533</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Muhammad Ikhlas Arsul&lt;sup&gt;1,2,&lt;/sup&gt;*, Muhamad Insanu&lt;sup&gt;1&lt;/sup&gt;, Irda Fidrianny&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Bandung Institute of Technology, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Alauddin Islamic State University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Heri Mulyati</style></author><author><style face="normal" font="default" size="100%">Ahmad Sulaeman</style></author><author><style face="normal" font="default" size="100%">Sri Anna Marliyati</style></author><author><style face="normal" font="default" size="100%">Mohamad Rafi</style></author><author><style face="normal" font="default" size="100%">Al Mukhlas Fikri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preclinical Trial of Propolis Extract in Prevention of High Salt Diet- Induced Hypertension</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antihypertension</style></keyword><keyword><style  face="normal" font="default" size="100%">Blood pressure</style></keyword><keyword><style  face="normal" font="default" size="100%">High-NaCl diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Stingless bee propolis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Propolis has been widely reported as having various biological activities. However, Indonesian propolis seems to be less explored. &lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to analyze the antihypertensive activity of Indonesian propolis in rats.&lt;strong&gt; Materials and Methods: &lt;/strong&gt;Hypertension was induced by high-NaCl (8%) diet for 3 weeks. A total of 36 rats were divided into 6 groups, including standard diet group (SD), high-NaCl diet group (NaD), high-NaCl diet group + captopril (25 mg/ kg) (PD), high-NaCl diet + propolis from Riau Archipelago (NaDP1), high-NaCl diet + propolis from Lampung (NaDP2) and high-NaCl diet + propolis from South Sulawesi (NaDP3). Propolis was daily administered at dose of 200 mg/ kg on hypertensive rats for 1 week. Blood pressure and body weight were weekly measured. Moreover, routine urine analysis, haematological parameters and lipid profiles at week 4 were determined.&lt;strong&gt; Results:&lt;/strong&gt; The results showed that high-NaCl diet successfully induced hypertension in rats after 3 weeks of intervention. However, the diet did not cause weight gain (p&amp;gt;0.05). All Indonesian propolis samples significantly reversed either systolic or diastolic blood pressure of hypertensive rats. From urine analysis, propolis from Riau Archipelago and Lampung showed diuretic effect. The haematological analysis mainly showed no significant difference compared standard diet group. Furthermore, LDL and HDL concentrations were significantly improved by propolis from Lampung and South Sulawesi, respectively (p&amp;lt;0.05). In addition, we only found significant decrease in relative weight of liver in all groups administered with high-NaCl diet (p&amp;lt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study suggests that all Indonesian propolis possessed antihypertensive activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Heri Mulyati&lt;sup&gt;1,2&lt;/sup&gt;, Ahmad Sulaeman&lt;sup&gt;1,&lt;/sup&gt;*, Sri Anna Marliyati&lt;sup&gt;1&lt;/sup&gt;, Mohamad Rafi&lt;sup&gt;3&lt;/sup&gt;, Al Mukhlas Fikri&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Pakuan, Bogor 16163, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maryam Riyadh Yaseen</style></author><author><style face="normal" font="default" size="100%">Ghasak G Faisal</style></author><author><style face="normal" font="default" size="100%">Azliana Abd Fuaat</style></author><author><style face="normal" font="default" size="100%">Khairunisa Ahmad Affandi</style></author><author><style face="normal" font="default" size="100%">Batoul Alallam</style></author><author><style face="normal" font="default" size="100%">Mohd Hamzah Mohd Nasir</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preparation of Euyrycoma Longifolia Jack (E.L) Tongkat Ali (Ta) Root Extract Hydrogel for Wound Application</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrogel</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic examination</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1456-1463</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; It is undeniable that a lot of patients worldwide suffer from different types of wounds. The complex process of wound healing has a severe effect on the life quality of patients as well as causing an economic load on healthcare institutions. Although the availability of various therapies for managing patients with acute and chronic wounds for the past decade, these therapies are usually expensive and accompanied by undesirable side effects. Hence, the discovery of a new arsenal for wound healing remains a hot topic of research. Recently, plants and their by-products have garnered remarkable attention as a source of therapeutic agents to treat wounds. This is because medicinal plants provide a rich reservoir of phytochemicals that could potentially become affordable and effective therapeutic agents. &lt;em&gt;Eurycoma longifolia &lt;/em&gt;Jack or Tongkat Ali (TA), is one of the well-known traditional plants of Malaysia, it has been scientifically proven to have medicinal properties. Hydrogels are hydrophilic polymer networks that can imbibe a significant number of fluids. In comparison to other systems developed for herbal medicines delivery, a unique power possessed by hydrogels is the high-water absorption ability. This ability has favoured the loading of herbal formulations, which are in general hydrophilic in nature, into hydrogels. &lt;strong&gt;Objective:&lt;/strong&gt; The aim of this study is to prepare&lt;em&gt; Eurycoma longifolia &lt;/em&gt;Jack (E.l.J) Tongkat Ali (TA) roots hydrogel for wound application.&lt;strong&gt; Methods:&lt;/strong&gt; Authentication of&lt;em&gt; Eurycoma longifolia &lt;/em&gt;Jack roots was done by microscopic examination using methylene blue and Lugol’s iodine solution. Root extraction by Soxhlet technique. In vitro cytotoxicity of ethanol extract of the roots was evaluated in human primary gingival fibroblasts cells. The ethanolic extract was loaded into hydrogel as a suitable dosage form for further wound healing studies.&lt;strong&gt; Results: &lt;/strong&gt;The crude herbal drug sample, TA present the same microscopical characters to that of E. longifolia Jack tap root. Ic50 was 118.5 μg/mL. The hydrogel was prepared using 2% xanthan gum and ethanol extract of TA was loaded successfully for its later application as a wound healing agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1456</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maryam Riyadh Yaseen&lt;sup&gt;1&lt;/sup&gt;, Ghasak G Faisal&lt;sup&gt;2&lt;/sup&gt;,*, Azliana Abd Fuaat&lt;sup&gt;3&lt;/sup&gt;, Khairunisa Ahmad Affandi&lt;sup&gt;3&lt;/sup&gt;, Batoul Alallam&lt;sup&gt;4&lt;/sup&gt;, Mohd Hamzah Mohd Nasir&lt;sup&gt;5&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pathology and Laboratory Medicine, Faculty of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Fundamental Dental and Medical Sciences, Faculty of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Assistant Professor, Department of Pathology and Laboratory Medicine, Faculty of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Technology, Faculty of pharmacy, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biotechnology, Faculty of Science, International Islamic University, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eem Masaenah</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Heri Setiawan</style></author><author><style face="normal" font="default" size="100%">Zahra Fadhilah</style></author><author><style face="normal" font="default" size="100%">Varda Arianti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Quantification of Andrographolide in Andrographis paniculata (Burm.f.) Nees, Myricetin in Syzygium cumini (L.) Skeels, and Brazilin in Caesalpinia sappan L. by HPLC Method</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Andrographis paniculata</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC</style></keyword><keyword><style  face="normal" font="default" size="100%">Marker compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Quality control</style></keyword><keyword><style  face="normal" font="default" size="100%">Syzygium cumini</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1437-1444</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction&lt;/strong&gt;: Andrographolide, myricetin, and brazilin are bioactive compounds from &lt;em&gt;Andrographis paniculata&lt;/em&gt;, &lt;em&gt;Syzygium cumini,&lt;/em&gt; and Caesalpinia &lt;em&gt;sappan &lt;/em&gt;plants that have potential as medicinal ingredients. Objectives: To determine the levels of andrographolide in A. paniculata herb extract (APE), myricetin in S. cumini leaf extract (SCE), and brazilin in &lt;em&gt;C. sappan&lt;/em&gt; wood extract (CSE) as marker compounds for extract quality control using the HPLC method. Methods: The separation was carried out on a reverse-phase C18 column (150 x 4.6 mm; 5 μm). The isocratic was prepared from methanol - water (50:50 v/v); 0.1% orthophosphoric acid - methanol (60:40 v/v); and 0,3% acetic acid - acetonitrile (85.5: 14.5 v/v) as mobile phase with flow rate 1 mL/min for andrographolide, myricetin, and brazilin determination, respectively and detection using UV detector at a wavelength of 254 nm, 369 nm, and 280 nm, respectively. Results: The linear regression for andrographolide was y = 14113x + 5948.8 (r2= 0.9994); myricetin was y = 87766x – 138895 (r2=0.9996); and brazilin was y = 18520x – 42668 (r2=0.9992). The andrographolide content in APE was found to be 14.4686 %. The myricetin content in SCE was found to be 0.3190 %. The brazilin content in CSE was found to be 2.1280 %. Conclusion: The described HPLC method was successfully used for the analysis of the APE, SCE, and CSE. This method can be used for the identification and quantification of andrographolide, myricetin, and brazilin in herbal raw materials or herbal products containing these three extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1437</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Eem Masaenah&lt;sup&gt;1,2&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,*&lt;/sup&gt;, Heri Setiawan&lt;sup&gt;1&lt;/sup&gt;, Zahra Fadhilah&lt;sup&gt;1&lt;/sup&gt;, Varda Arianti&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Sekolah Tinggi Teknologi Industri dan Farmasi, Bogor 16151, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gagan Tiwana</style></author><author><style face="normal" font="default" size="100%">Jiahe Fua</style></author><author><style face="normal" font="default" size="100%">Lanping Lu</style></author><author><style face="normal" font="default" size="100%">Matthew J Cheesman</style></author><author><style face="normal" font="default" size="100%">IE.Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review of the Traditional Uses, Medicinal Properties and Phytochemistry of Centaurea benedicta L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Blessed thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">St Benedict’s thistle</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpenoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">798-812</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Centaurea benedicta&lt;/em&gt; L. is an annual herbaceous plant which belongs to the Asteraceae family. It is native to the Mediterranean region and western Asia and is commonly known as blessed thistle, holy thistle, St Benedict’s thistle or spotted thistle. Traditionally, it has been used to treat bubonic plague and possesses diuretic, galactagogue, liver-strengthening and wound healing properties. Recent research studies have investigated its anticancer, antiinflammatory, antioxidant and other therapeutic properties. Several studies have also reported its antimicrobial activity against a range of bacterial pathogens. However, most of these studies were preliminary and only tested relatively high concentrations of the extracts. Additionally, most studies screened a limited number of pathogens. Cnicin is the main chemical compound present in &lt;em&gt;C. benedicta &lt;/em&gt;and it has been widely investigated. However, few other compounds from this plant have been identified and/or investigated, and further phytochemical studies are warranted. Interestingly, pure cnicin has good anticancer activity, whilst the crude extracts lack cytotoxic properties. Phytochemical analyses of&lt;em&gt; C. benedicta &lt;/em&gt;extracts reveal the presence of multiple flavonoids, tannins, terpenoids and lactones, although few specific phytochemicals within these phytochemical classes have been identified. A limited number of research studies have determined the toxicity profile of &lt;em&gt;C. benedicta &lt;/em&gt;in order to evaluate its safety for human use. Substantially more detailed studies are required to rigorously investigate the therapeutic properties and phytochemistry of &lt;em&gt;C. benedicta&lt;/em&gt;, which may ultimately lead to the development of new plant-based therapeutic medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">798</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gagan Tiwana&lt;sup&gt;1,2&lt;/sup&gt;, Jiahe Fua&lt;sup&gt;2&lt;/sup&gt;, Lanping Lu&lt;sup&gt;2&lt;/sup&gt;, Matthew J. Cheesman&lt;sup&gt;1,3&lt;/sup&gt;, I.E.Cock&lt;sup&gt;2,4,&lt;/sup&gt;*&amp;nbsp;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Pharmacy and Pharmacology, Gold Coast Campus, Griffith University, Parklands Drive, Southport, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Menzies Health Institute Queensland, Quality Use of Medicines Network, Queensland 4222, AUSTRALIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, Brisbane, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohammad Sukmanadi</style></author><author><style face="normal" font="default" size="100%">Mustofa Helmi Effendi</style></author><author><style face="normal" font="default" size="100%">Faisal Fikri</style></author><author><style face="normal" font="default" size="100%">Muhammad Thohawi Elziyad Purnama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Role of Capsaicin in the Repair of Cellular Activity in Mice Liver</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aflatoxin B1</style></keyword><keyword><style  face="normal" font="default" size="100%">Animal</style></keyword><keyword><style  face="normal" font="default" size="100%">Capsaicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibroblast.</style></keyword><keyword><style  face="normal" font="default" size="100%">Kupffer cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Stellate</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1573-1576</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to determine the capsaicin efficacy on Kupffer cell, polymorphonuclear, stellate, and fibroblast cells in mice liver induced with aflatoxin B1. A total of 20 mice were used as sample, assigned into four group i.e. (T0) administered 0,5 ml of polyethylene glycol, (T1) administered 0,5 ml of capsaicin + 0,5 ml of polyethylene glycol, (T2) administered 0,1 ml of aflatoxin B1 + 0,5 ml of polyethylene glycol, (T3) administered 0,1 ml of aflatoxin B1 + 0,5 ml of capsaicin, respectively. All treatment were done for a month then followed by liver dissection for hematoxylin eosin staining. The differential cells counted then analyzed using ANOVA and Tukey multiple comparison test (p&amp;lt;0,05). The cell determination showed that Kupffer cell, polymorphonuclear, stellate, and fibroblast cells decreased significantly (p&amp;lt;0,05) in T3 group compared to T2 group. Meanwhile, the T1 group showed similar (p&amp;gt;0,05) with T0 group. It can be concluded that capsaicin has a potential effect to improve cellular activity in mice liver with aflatoxin B1 toxication.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1573</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Mohammad Sukmanadi&lt;sup&gt;1&lt;/sup&gt;, Mustofa Helmi Effendi&lt;sup&gt;2&lt;/sup&gt;,&lt;sup&gt;*&lt;/sup&gt;, Faisal Fikri&lt;sup&gt;3&lt;/sup&gt;, Muhammad Thohawi Elziyad Purnama&lt;sup&gt;4&lt;/sup&gt;.&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;SubDivision of Veterinary Pharmacy, Division of Veterinary Basic Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Division of Veterinary Public Health, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;SubDivision of Veterinary Pharmacology, Division of Veterinary Basic Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Division of Veterinary Anatomy, Department of Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Okid Parama Astirin</style></author><author><style face="normal" font="default" size="100%">Adi Prayitno</style></author><author><style face="normal" font="default" size="100%">Anif Nur Artanti</style></author><author><style face="normal" font="default" size="100%">Elisa Herawati</style></author><author><style face="normal" font="default" size="100%">Afiyati Nur ‘Aini Saad</style></author><author><style face="normal" font="default" size="100%">Ajeng Dara Firstlia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Single-Dose and Combined-Dose of Nanoparticles from Soursop Leaves (Annona muricata L.) and Sappan Wood (Caesalpinia sappan L.) Induced Apoptosis and Necrosis in HeLA Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan L.</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">Necrosis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1134-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Apart from the medical advancement of chemotherapy, various plants were known as beneficial for cancer therapy because they can kill cancer cells selectively without damaging the normal cells. Here, we showed that nanoparticles formulated from chloroform fraction of soursop (&lt;em&gt;Annona muricata&lt;/em&gt; L.) leaves and ethyl acetate fraction of sappan wood (&lt;em&gt;Caesalpinia sappan&lt;/em&gt; L.) have anti-proliferative and cytotoxic effects on HeLa cervical cancer cells. &lt;strong&gt;Methods: &lt;/strong&gt;The cytotoxic effect was evaluated using a single dose of each nanoparticle and a combined dose to obtain a synergistic effect. The mechanism of induced cell death via apoptosis or necrosis pathway was evaluated using flow cytometry by incorporating Annexin V and propidium iodide.&lt;strong&gt; Results: &lt;/strong&gt;Synthesis of nanoparticles from the extract of soursop leaves (nano-SL) and extract of sappan wood (nano-SW) yielded particle sizes ranging from 248 to 317 nm. Nano-SL and nano-SW decreased the viability of HeLa cervical cancer cells in a dose-dependent manner with IC&lt;sub&gt;50 &lt;/sub&gt;values of 63,32 μg/ml dan 40,88 μg/ml, respectively. The combined dose of 1/8 IC&lt;sub&gt;50&lt;/sub&gt; from both nanoparticles showed a strong synergistic effect, as shown by the combination index value of 0.13 based on the same mode of action and different modes of action. In HeLa cells treated with a combined dose of nanoparticles, the total apoptotic cells increased two times greater than that in control cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;Nano-SL and nano-SW induce apoptosis and necrosis in HeLa cells. Combined-dose of both nanoparticles produced a synergistic effect that could reduce the amount of the required individual dose while increasing the total effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1134</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Okid Parama Astirin&lt;sup&gt;1&lt;/sup&gt;, Adi Prayitno&lt;sup&gt;2&lt;/sup&gt;, Anif Nur Artanti&lt;sup&gt;3&lt;/sup&gt;, Elisa Herawati&lt;sup&gt;1,&lt;/sup&gt;*, Afiyati Nur ‘Aini Saad&lt;sup&gt;1&lt;/sup&gt;, Ajeng Dara Firstlia&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Mathematics and Natural Sciences, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pathobiology, Faculty of Medicine, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Vocational College, Sebelas Maret University, Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rahmi Muthia</style></author><author><style face="normal" font="default" size="100%">Helmina Wati</style></author><author><style face="normal" font="default" size="100%">Wahyudin Bin Jamaludin</style></author><author><style face="normal" font="default" size="100%">Kartini</style></author><author><style face="normal" font="default" size="100%">Finna Setiawan</style></author><author><style face="normal" font="default" size="100%">Muhammad Fikri</style></author><author><style face="normal" font="default" size="100%">Abdul Wahhab</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Standardization of Eleutherine bulbosa Urb. Bulbs and Total Flavonoid Content from Three Locations in Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eleutherine bulbosa Urb.</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">Specific parameters</style></keyword><keyword><style  face="normal" font="default" size="100%">standardization</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">73-80</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dayak Onion (&lt;em&gt;Eleutherine bulbosa&lt;/em&gt; Urb.) is a typical plant of Kalimantan which is traditionally used by the Dayak community as a medicinal plant. Dayak onion bulbs have been proven had many pharmacology activities. &lt;strong&gt;Objective: &lt;/strong&gt;This study aims to determine the nonspesific and specific parameters of 70% ethanol extract of &lt;em&gt;Eleutherine bulbosa &lt;/em&gt;Urb. Total flavonoids was also quantified &lt;strong&gt;Methods:.&lt;/strong&gt; &lt;em&gt;Eleutherine bulbosa&lt;/em&gt; Urb was extracted with maseration method used etanol 70 % as solvent. Determination of non-spesific includes by determined specific gravity, water content, total ash content, acid insoluble ash content, residual sovents, heavy metanol contamination, microbial contamination, mold and yeast contamination. Determination of specific parameters included extract identity, organoleptic extract, water/ethanol soluble content, chromatography profile. Total flavonoid content were quantified with colorimetric method. &lt;strong&gt;Results: &lt;/strong&gt;there were no significance difference between nonspesific and specific parameters &lt;em&gt;Eleutherine bulbosa&lt;/em&gt; Urb from three different locations. Measurement of total phenol content and total flavonoid content respectively form South Borneo were ; 6,499 ± 0,5248 mg QE/g extract, from central borneo were 7,585 ± 0,0437 mgQE/g extract, and from east borneo were 5,035 mg ± 0,3887 mgQE/g extract. &lt;strong&gt;Conclusion: &lt;/strong&gt;it can be concluded that bulbs of &lt;em&gt;Eleutherine bulbosa &lt;/em&gt;Urb from three locations have characters to similar between each other and bulbs of &lt;em&gt;Eleutherine bulbosa&lt;/em&gt; Urb form central borneo had the highest total flavonoid content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rahmi Muthia&lt;sup&gt;1,&lt;/sup&gt;*, Helmina Wati&lt;sup&gt;2&lt;/sup&gt;, Wahyudin Bin Jamaludin&lt;sup&gt;3&lt;/sup&gt;, Kartini&lt;sup&gt;4&lt;/sup&gt;, Finna Setiawan&lt;sup&gt;5&lt;/sup&gt;, Muhammad Fikri&lt;sup&gt;1&lt;/sup&gt;, Abdul Wahhab&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departement of Pharmacognosy and Phytochemstry, Borneo Lestari College of Health Sciences, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departement of Pharmacology, Borneo Lestari College of Health Sciences, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departement of Pharmaceuticals, Borneo Lestari College of Health Sciences, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Pharmaceutical Biology Departement, Faculty of Pharmacy, Surabaya University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pharmacology Departement, Faculty of Pharmacy, Surabaya University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Syaza Safia Fouzi</style></author><author><style face="normal" font="default" size="100%">Noor Zarina Abd Wahab</style></author><author><style face="normal" font="default" size="100%">Leong Chee Yan</style></author><author><style face="normal" font="default" size="100%">Nazlina Ibrahim</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Styrylpyrone Derivative from Goniothalamus sp.: A Powerful Drug for Fighting Against Herpes Simplex Virus Type 1</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Herpes Virus type 1 (HSV-1)</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico approaches</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking and Styrylpyrone derivative.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1598-1606</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The emergence of drug resistance towards Herpes Simplex Virus Type 1 (HSV-1) has encouraged scientists to develop novel lower toxicity and highly effective anti-HSV drugs. Styrylpyrone derivative (SPD) is a bioactive compound isolated from the roots and leaves of Goniothalamus sp. It is believed that this compound possesses antiviral properties against HSV-1. &lt;strong&gt;Objective: &lt;/strong&gt;This paper introduces the interaction of SPD towards HSV-1 through in silico study of molecular docking and molecular dynamic simulation.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; Molecular docking is a computational tool which is used to study the molecular interaction between two or more structures. ADME/T properties of the SPD were generated using the SwissADME online tool in which SPD was found to have a good pharmacokinetic profile. &lt;strong&gt;Results:&lt;/strong&gt; Molecular docking study revealed that SPD has a high docking score of -7.9 Kcal/mol. SPD has a strong affinity with the thymidine kinase (PDB id: 1OF1) producing hydrogen bond and non-polar interaction at the target point of amino acid residue. &lt;strong&gt;Conclusion:&lt;/strong&gt; Molecular docking analysis provides new insight into the structure-based design of SPD compounds with better antiviral activity against HSV-1.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1598</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Syaza Safia Fouzi&lt;sup&gt;1&lt;/sup&gt;, Noor Zarina Abd Wahab&lt;sup&gt;2&lt;/sup&gt;, Leong Chee Yan&lt;sup&gt;1&lt;/sup&gt;, Nazlina Ibrahim&lt;sup&gt;1&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biological Science and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biomedicine, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu, MALAYSIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ololade Zacchaeus S</style></author><author><style face="normal" font="default" size="100%">Anuoluwa Iyadunni A</style></author><author><style face="normal" font="default" size="100%">Adeyemi Adewale F</style></author><author><style face="normal" font="default" size="100%">Uyaboerigha Daubotei I</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synergistic Efficacy of Phytochemical, Antioxidant and Bactericidal Properties of the Aerial Essential Oil of Laggera crispata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Aerial essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Asteraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Laggera crispata</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolites</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1304-1311</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study was undertaken to provide more scientific information about the phytochemical composition of Laggera crispata known for its medicinal uses. Essential oil was isolated by hydro-distillation, analysed using GC-MS, UV-Visible Spectrophotometer and other established biochemical assays were used for the study. The GC-MS analysis of the aerial essential oil of&lt;em&gt; L. crispata&lt;/em&gt; showed the presence of 35 medicinal organic compounds making up 84.4% of the oil. The most abundant component was a phenolic compound called 2-tert-Butyl&lt;sup&gt;-1&lt;/sup&gt;,4-dimethoxybenzene (54.5%). The other major terpenoids present in the oil were α-humulene (6.9%) and (+)-sabinene (5.9%). The TPC, TFC, TAA and TAC values of the aerial essential oil of &lt;em&gt;L. crispata &lt;/em&gt;were 172.75±0.00 μgmg&lt;sup&gt;-1&lt;/sup&gt; GAE, 48.69±0.00 μgmg&lt;sup&gt;-1&lt;/sup&gt; QE, 61.85±0.00 μgmg&lt;sup&gt;-1&lt;/sup&gt; AAE and 726.92±0.00 μgmg&lt;sup&gt;-1&lt;/sup&gt; AAE respectively. DPPH IC&lt;sub&gt;50 &lt;/sub&gt;and AAI values of the essential oil were 1.5 μgml&lt;sup&gt;-1&lt;/sup&gt; and 26.7. The essential oil displayed varying inhibitory activities against Gram-positive and Gram-negative bacteria with zones of inhibition ranging from 08-30 mm. The&lt;em&gt; in vitro&lt;/em&gt; pharmacological activities added scientific support to the use of &lt;em&gt;L. crispata&lt;/em&gt; in alternative and complementary medicine. The essential oil of &lt;em&gt;L. crispata&lt;/em&gt; grown in Nigeria will play beneficial roles in human and animal health and therefore a research on this plant might be of great value in drug industries.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1304</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ololade Zacchaeus S&lt;sup&gt;1,&lt;/sup&gt;*, Anuoluwa Iyadunni A&lt;sup&gt;2&lt;/sup&gt;, Adeyemi Adewale F&lt;sup&gt;1&lt;/sup&gt;, Uyaboerigha Daubotei I&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemistry, University of Medical Sciences, Ondo, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biological Sciences, University of Medical Sciences, Ondo, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Plant Biology and Biotechnology, University of Benin, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Usama Fathy</style></author><author><style face="normal" font="default" size="100%">Rasha S Gouhar</style></author><author><style face="normal" font="default" size="100%">Ahmed Younis</style></author><author><style face="normal" font="default" size="100%">Dina H El-Ghonemy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis of Novel pyrimido[4,5-b]quinoline-4-one Derivatives and Assessment as Antimicrobial and Antioxidant Agents</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antimicrobial agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Benzoxazinones</style></keyword><keyword><style  face="normal" font="default" size="100%">Pyrimidoquinolin</style></keyword><keyword><style  face="normal" font="default" size="100%">Quinoline</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">550-562</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Antimicrobial resistance has emerged as one of the serious global health problems of the 21&lt;sup&gt;st&lt;/sup&gt; century that threatens the efficient treatment and prevention of an everincreasing range of infections caused by bacteria, viruses, and fungi. Therefore, it would be favorable to find promising agents with antioxidant and antimicrobial activity combined in one molecule. &lt;strong&gt;Key findings:&lt;/strong&gt; Pyrimido[4,5-b] quinolines are biologically active compounds that are known to rely primarily on the functional group’s existence and location. Quinolinbenzo-[ 1,3]oxazin-4-one &lt;strong&gt;(3)&lt;/strong&gt; was prepared and played as electrophilic interface/mediator for the synthesis of many compounds, such as pyrimido[4,5-b]quinoline, quinoline-carboxamide and oxoquinazolin-acetamide by reacting with nucleophilic reagent. &lt;strong&gt;Summary: &lt;/strong&gt;Results revealed that pyrimido[4,5-b] quinoline derivatives (&lt;strong&gt;17b, 9d&lt;/strong&gt; and &lt;strong&gt;9c&lt;/strong&gt;) are the most potent compounds that displayed significant antimicrobial activity along with compounds 17a, 29b, 5, 19, 23b, and 25b that appeared to be more promising as antioxidant agents than ascorbic acid.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">550</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Usama Fathy&lt;sup&gt;1,&lt;/sup&gt;*, Rasha S. Gouhar&lt;sup&gt;2&lt;/sup&gt;, Ahmed Younis&lt;sup&gt;3&lt;/sup&gt;, Dina H. El- Ghonemy&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Applied Organic Chemistry Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki-Giza- P.O.12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Therapeutic Chemistry Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki-Giza- P.O.12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Green Chemistry Department, National Research Centre, 33 El Bohouth st. (former EL Tahrir st.)-Dokki-Giza- P.O.12622, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Microbial Chemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, 33 El Buhouth St., Dokki, Cairo, P. C. 12622, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Abdur Rauf</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author><author><style face="normal" font="default" size="100%">Victor Fernández-Guzmán</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticarcinogenic agent</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Breast tumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Preventive medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">562-568 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To determine the ameliorative effect of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) on 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats. &lt;strong&gt;Methods: &lt;/strong&gt;36 female Holztman rats were divided into 6 groups. I) The negative control group received physiological saline (PS). II) ChS-200 group received 200 mg/kg of ChS. III) DMBA group was induced with DMBA (20 mg/Kg) dissolved in PS and administrated orally for 15 weeks. IV) DMBA + ChS-50 group, V) DMBA + ChS-250 group, and VI) DMBA + ChS-500 group, which received the extract orally for 15 weeks after DMBA induction. All data were expressed as mean and standard deviation. One-way analysis of variance (ANOVA) followed by Dunnet test was carried out to compare the mean value of different groups Histopathological analysis was evaluated by using Image J software. &lt;strong&gt;Results: &lt;/strong&gt;Hematology showed that the triglyceride level was significantly lowered (P&amp;lt; 0.01) and high-density lipoprotein (HDL) level was significantly increased (P &amp;lt;0.01) in groups III, IV and V. Also, ChS extract significantly lowered the C reactive protein (CRP) level (P &amp;lt;0.01) and malondialdehyde level (P&amp;lt;0.05). There was a significant decrease in the frequency of DMBA-induced micronucleated polychromatic erythrocyte (P&amp;lt;0.01). &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt;&lt;strong&gt; &lt;/strong&gt;Chuquiraga spinosa&lt;/em&gt; showed an ameliorative effect on DMBA-induced breast cancer in rats as well as antioxidant, antitumor and antigenotoxic properties.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">562</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera-Calderon&lt;sup&gt;2,&lt;/sup&gt;*, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Abdur Rauf&lt;sup&gt;4&lt;/sup&gt;, Renán Hañari-Quispe&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa-Salvador&lt;sup&gt;6&lt;/sup&gt;, Victor Fernández-Guzmán&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Academic Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Academic Department of Human Medicine, School of Pharmacy and Biochemistry, Universidad Nacional San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, University of Swabi, Swabi-23430, KPK, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Clinic Pathology, Faculty of Veterinary medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Graduate School of Business, ESAN University, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Victoria Vladimirovna Fedotova</style></author><author><style face="normal" font="default" size="100%">Dmitry Alexeevich Konovalov</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anatomical Characteristics of Leaves and Flowers of Cornus sanguine subsp. australis (C.A.Mey.) Jav.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Collenchyma</style></keyword><keyword><style  face="normal" font="default" size="100%">Cornus sanguinea subsp. australis (C.A.Mey.) Jav.</style></keyword><keyword><style  face="normal" font="default" size="100%">Cross-section</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesophyll</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomatal anomocytic type</style></keyword><keyword><style  face="normal" font="default" size="100%">Vascular bundle</style></keyword><keyword><style  face="normal" font="default" size="100%">Т-shaped trichomes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">448-451</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Cornus sanguinea &lt;/em&gt;subsp. &lt;em&gt;australis &lt;/em&gt;(C.A.Mey.) Jav. is a widespread plant of the Caucasus (Russia). This is a small decorative tree with a large mass of raw material of leaves and flowers, which contain phenolic compounds. Currently, this plant is used in traditional medicine in some countries. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;&lt;em&gt;C. australis &lt;/em&gt;leaves, and flowers were collected during the flowering period on the Mount Mashuk in Pyatigorsk, Stavropol region, Russia in June 2019. The anatomical structure of &lt;em&gt;C. australis &lt;/em&gt;is considered in accordance with the requirements of the State Pharmacopoeia XIV.&lt;strong&gt; Results:&lt;/strong&gt; There are heavily sinuous walls of cells of the upper and lower epidermis in microscopy of the leaves of &lt;em&gt;C. australis,&lt;/em&gt; stomatal anomocytic type, Т-shaped trichomes, two types of mesophyll: palisade and spongy. In the vascular system of the leaf and petiole, there are two vascular bundles: small and larger. In the small vascular bundle, the xylem is located from the abaxial surface, the phloem – from the adaxial surface, in the big vascular bundle on the contrary. The lower epidermis of the petal and sepal is covered with T-shaped trichomes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Obtained anatomical signs are necessary for identification, authenticity, standardization for the use of &lt;em&gt;C. australis&lt;/em&gt; as raw materials for pharmaceutical purposes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">448</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Victoria Vladimirovna Fedotova&lt;sup&gt;1&lt;/sup&gt;, Dmitry Alexeevich Konovalov&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical and Pharmaceutical Institute, a Branch of Volgograd State Medical University Ministry of Health of Russian Federation, Pyatigorsk, 357532, Kalinina 11, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Rista Putrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anticancer Activity of Ruellia britoniana Flower on Cervical HeLa Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cervical HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Ruellia brittoniana</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">29-34</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cervical cancer ranks 4&lt;sup&gt;th&lt;/sup&gt; in terms of the mortality rates and incidence of all cancers in women (GLOBOCAN 2018). In last decade, there is a significance progress in cancer therapy followed by an increase in the cost of cancer treatment. Therefore, it is necessary to have therapeutic innovations that are expected to reduce the cost of cervical cancer therapy. One therapeutic innovation that is currently being intensively carried out is herbal medicine. Some researchers have found that some plant extracts have anti-cancer properties that can be an alternative treatment for cancer, such as some plants with the genus &lt;em&gt;Ruellia&lt;/em&gt;, such as &lt;em&gt;Ruellia tuberosa &lt;/em&gt;and &lt;em&gt;Ruellia squarrosa&lt;/em&gt;. However, research on the anticancer activity of the species of &lt;em&gt;Ruellia brittoniana&lt;/em&gt;, especially the flowers, is still limited. &lt;strong&gt;Objective: &lt;/strong&gt;Aim of this study is to examine anti-cervical cancer activity of &lt;em&gt;R. brittoniana&lt;/em&gt; flower. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;R.brittoniana&lt;/em&gt; flowers were obtained from Depok, West Java, Indonesia. The flowers are extracted gradually with n-hexane, ethyl acetate, and ethanol solvents. The extracts were evaluated for anticancer activity by MTT method.&lt;strong&gt; Results: &lt;/strong&gt;IC&lt;sub&gt;50&lt;/sub&gt; values for ethanol extract, ethyl acetate extract and n-hexane extract of &lt;em&gt;R. brittoniana&lt;/em&gt; flowers are 116.55 ppm, 52.62 ppm, and 123.09 ppm, respectively, which indicating that ethanol extract has moderate anticancer activity, while ethyl acetate and n-hexane extract of &lt;em&gt;R. brittoniana&amp;nbsp;&lt;/em&gt;flowers have weak anticancer activity.&lt;strong&gt; Conclusion:&lt;/strong&gt; Ethanol, ethyl acetate, and n-hexane extract of &lt;em&gt;R.brittoniana&lt;/em&gt; flowers have a potential to become natural anti-cervical cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">29</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nadzila Anindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Rista Putrianingsih&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Heru Sasongko</style></author><author><style face="normal" font="default" size="100%">Ratih Guswinda Lestari</style></author><author><style face="normal" font="default" size="100%">Adi Yugatama</style></author><author><style face="normal" font="default" size="100%">Yeni Farida</style></author><author><style face="normal" font="default" size="100%">Sugiyarto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidiabetic and Antioxidant Effect Combination Vasconcellea pubescens A.DC. and Momordica charantia L. Extract in Alloxan- Induced Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Momordica</style></keyword><keyword><style  face="normal" font="default" size="100%">Synergistic</style></keyword><keyword><style  face="normal" font="default" size="100%">Vasconcellea</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">311-315</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Mountain papaya (&lt;em&gt;Vasconcellea pubescens&lt;/em&gt; A.DC.) and bitter melon (Momordica charantia L.) fruit extract have total flavonoids and some metabolite from its contains. The use of a single dose in the treatment of diabetes is often considered to lack a strong effect. Giving a combination of the compound is a solution to provide a synergistic effect in treatment. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Rat were divided into eight groups (normal, negative control, glibenclamide as a positive control, and five dose extract group). The single dose mountain papaya extract (MPE) and bitter melon extract (BME) were given at 174 mg/kg b.w of MPE, and 380 mg/kg b.w of BME in oral administration. Combination of MPE:BME (25:75, 50:50, 75:25)% or (87:190; 44:285 and 130:95) mg/kg b.w in oral administration. Induction of diabetes used alloxan dose of 150 mg/kg b.w intraperitoneally. The treatment was performed for 21 days with a frequency of once a day. Blood sugar level was measured at pretest, 7&lt;sup&gt;th&lt;/sup&gt;, 14&lt;sup&gt;th&lt;/sup&gt;, and 21&lt;sup&gt;st &lt;/sup&gt;days. At the end of the test, measurements of malondialdehyde (MDA), glutathione (GSH), and pancreatic morphology were measured. Data were analyzed by ANOVA statistic. &lt;strong&gt;Results: &lt;/strong&gt;The single and combination of MPE-BME showed an decrease in blood glucose levels significantly compared with the negative control (&lt;em&gt;p&lt;/em&gt; ≤ 0.05). The same results from measurements of levels of malondialdehyde (MDA), glutathione (GSH), and pancreatic morphology. &lt;strong&gt;Conclusions:&lt;/strong&gt; Based on the research, a combination of the MPE-BME had antidiabetic and antioxidant activity, but the activity was not significantly different from both single-dose extract (&lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">311</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Heru Sasongko&lt;sup&gt;1,&lt;/sup&gt;* , Ratih Guswinda Lestari&lt;sup&gt;1&lt;/sup&gt;, Adi Yugatama&lt;sup&gt;1&lt;/sup&gt;, Yeni Farida&lt;sup&gt;1&lt;/sup&gt;, Sugiyarto&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Universitas Sebelas Maret, Jl. Ir. Sutami No. 36 A, Surakarta 57126, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Universitas Sebelas Maret, Jl. Ir. Sutami No. 36 A, Surakarta 57126, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Twinkle Francis</style></author><author><style face="normal" font="default" size="100%">S Rajeshkumar</style></author><author><style face="normal" font="default" size="100%">Anita Roy</style></author><author><style face="normal" font="default" size="100%">T Lakshmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory and Cytotoxic Effect of Arrow Root Mediated Selenium Nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine shrimp</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Selenium nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1363-1367</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Nanoparticles serve to reduce toxicity, enhance bioactivity and improve targeting. Selenium nanoparticles (SeNPs) are explored because of it’s unique characteristics and various known therapeutic benefits such as antioxidants activities and reducing risk of cancer. In this study, arrow root which is a starch obtained from tapioca or cassava is mediated with SeNPs and studied for it’s anti-inflammatory and cytotoxic effect. The plant extract of arrow root was prepared and mixed with the sodium selenite solution. The solution is kept in a magnetic stirrer while being observed for any colour change. The synthesis of nanoparticles is observed using UV-vis spectrophotometry. Then the anti-inflammatory activity is observed using albumin denaturation assay and cytotoxic analysis conducted on brine shrimp nauplii. The results showed that there was a lower toxicity rate of SeNPs and significant anti-inflammatory activity which concludes that these nanoparticles can be used in various drug designing aspects in future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1363</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Twinkle Francis, S Rajeshkumar*, Anita Roy, T Lakshmi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospital, SIMATS, Chennai – 600077, TN, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raceline Gounoue Kamkumo</style></author><author><style face="normal" font="default" size="100%">Abel Narcisse Messi Betene</style></author><author><style face="normal" font="default" size="100%">Patrick Valere Tsouh Fokou</style></author><author><style face="normal" font="default" size="100%">Jean Hubert Donfack</style></author><author><style face="normal" font="default" size="100%">Marius Jaurès Tsakem Nangap</style></author><author><style face="normal" font="default" size="100%">Albertine Ngako</style></author><author><style face="normal" font="default" size="100%">Roberto Fokou</style></author><author><style face="normal" font="default" size="100%">Mariscal Brice Tchatat Tali</style></author><author><style face="normal" font="default" size="100%">Florence Ngueguim Tsofack</style></author><author><style face="normal" font="default" size="100%">Théophile Dimo</style></author><author><style face="normal" font="default" size="100%">Fabrice Fekam Boyom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimalarial Effects of the Aqueous Extract of Entandrophragma angolense Bark on Plasmodium berghei Infection in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiplasmodial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">E. angolense</style></keyword><keyword><style  face="normal" font="default" size="100%">Malaria infection</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">P. berghei</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">687-698</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Research for new antimalarial drugs remains a permanent quest for the control of malaria. &lt;strong&gt;Objective:&lt;/strong&gt; The present study investigates the effects of the aqueous extract of &lt;em&gt;Entandrophragma angolense&lt;/em&gt; bark on&lt;em&gt; P. berghei-&lt;/em&gt;induced malaria in mice. &lt;strong&gt;Methods: &lt;/strong&gt;Eight weeks old mice, were intraperitoneally infested with 200 μl of blood, containing 1x10&lt;sup&gt;6&lt;/sup&gt; &lt;em&gt;P. berghei&lt;/em&gt;-infected-erythrocytes. Parasitaemia was determined using a 10% giemsa stained blood smear read under optical microscope (x100). The infected animals were randomized into 5 groups of 10 animals each and daily treated for 5 days with the plant extract at 125, 250 and 500 mg/kg. The normal control and malaria control received water while the chloroquine control was treated with 10 mg/kg of chloroquine. Body weight, parasitaemia and survival time were monitored daily during treatment and follow up periods. Five animals from each group were sacrificed under anaesthesia at the end of treatment (d8) and after the follow up period (d28). Venous blood was used for haematological and biochemical tests. Organs (liver, kidneys and spleen) were also collected for biochemical and histological analyses. &lt;strong&gt;Results: &lt;/strong&gt;Administration of the aqueous extract of &lt;em&gt;E. angolense &lt;/em&gt;bark to infected mice significantly inhibited parasite development (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.001) with ED&lt;sub&gt;50&lt;/sub&gt; estimated at 25.32 mg/kg. The extract prevented animal from death, body weight loss, anaemia, leucocytosis, high transaminases (ALT and AST), high bilirubin, creatinine and MDA levels, oxidative stress and anatomical alteration in organs as compared to the malaria control.&lt;strong&gt; Conclusion:&lt;/strong&gt; The &lt;em&gt;E. angolense &lt;/em&gt;bark possesses antimalarial properties, supporting its use in traditional medicine to treat malaria.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">687</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raceline Gounoue Kamkumo&lt;sup&gt;1,2,&lt;/sup&gt;*, Abel Narcisse Messi Betene&lt;sup&gt;1,2&lt;/sup&gt;, Patrick Valère Tsouh Fokou&lt;sup&gt;2,3&lt;/sup&gt;, Jean Hubert Donfack&lt;sup&gt;4&lt;/sup&gt;, Marius Jaurès Tsakem Nangap&lt;sup&gt;1,2&lt;/sup&gt;, Albertine Ngako&lt;sup&gt;1,2&lt;/sup&gt;, Roberto Fokou&lt;sup&gt;1,2&lt;/sup&gt;, Mariscal Brice Tchatat Tali&lt;sup&gt;2&lt;/sup&gt;, Florence Ngueguim Tsofack&lt;sup&gt;1&lt;/sup&gt;, Théophile Dimo&lt;sup&gt;1&lt;/sup&gt;, Fabrice Fekam Boyom&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Biology and Physiology, University of Yaoundé 1, P.O. Box 812, Yaounde, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Science, University of Bamenda, P.O. Box 39, Bamenda, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Sciences, University of Dschang, P.O. Box 67, Dschang, CAMEROON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Helmi</style></author><author><style face="normal" font="default" size="100%">Nanang Fakhrudin</style></author><author><style face="normal" font="default" size="100%">Arief Nurrochmad</style></author><author><style face="normal" font="default" size="100%">Ari Sudarmanto</style></author><author><style face="normal" font="default" size="100%">Zullies Ikawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Caesalpinia sappan L. Wood is a Potential Source of Natural Phosphodiesterase-1 Inhibitors</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brazilin</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia sappan L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal cognitive enhancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Phosphodiesterase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotheraphy</style></keyword><keyword><style  face="normal" font="default" size="100%">Tetraacetylbrazilin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1206-1217</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;A decrease in cAMP and cGMP levels in the brain is linked to human cognitive problems. The degradation of cellular cAMP and cGMP is attributed to phosphodiesterases (PDEs), which constitute a superfamily of enzymes. The inhibition of PDE1 is a promising mechanism to increase cAMP and cGMP levels associated with cognitive disorders. &lt;em&gt;Caesalpinia sappan&lt;/em&gt; L. (CS) wood is a natural coloring agent usually consumed as a traditional refreshment or drink by people in Yogyakarta, Indonesia. However, scientific evidence regarding the inhibitory activity of CS wood against PDE1 has yet to be obtained. This study aimed to investigate the potency of CS wood as a PDE1 inhibitor. &lt;strong&gt;Methods: &lt;/strong&gt;The ethanol extract of CS wood and its fractions were evaluated &lt;em&gt;in vitro&lt;/em&gt; by using a cyclic nucleotide phosphodiesterase assay kit. The presence of brazilin in the extract and fractions was analyzed by thin-layer chromatography.&lt;em&gt; In silico &lt;/em&gt;assay was performed using MOE software to obtain insights into the interaction between compounds in the CS wood and the enzyme. &lt;strong&gt;Results: &lt;/strong&gt;Ethanol extract and ethyl acetate soluble fraction effectively inhibited the PDE1 activity. Interestingly, brazilin, the major compound in CS wood, also exhibited a potent inhibitory effect on the enzyme. The &lt;em&gt;in silico &lt;/em&gt;assay revealed that the interaction between tetraacetylbrazilin and brazilin with the PDE1B active site involved hydrogen bonding and π–π interactions. &lt;strong&gt;Conclusion: &lt;/strong&gt;Ethanol extract, ethyl acetate soluble fraction, and brazilin inhibited the PDE1 activity. CS wood and its chemical constituent could be developed as natural cognitive enhancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1206</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Helmi&lt;sup&gt;1&lt;/sup&gt;, Nanang Fakhrudin&lt;sup&gt;2,&lt;/sup&gt;*, Arief Nurrochmad&lt;sup&gt;3&lt;/sup&gt;, Ari Sudarmanto&lt;sup&gt;4&lt;/sup&gt;, Zullies Ikawati&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Surya Dwira</style></author><author><style face="normal" font="default" size="100%">Ariska TP</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Linda Erlina</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Cytotoxicity between Ethyl Acetate and Ethanol Extract of White Turmeric (Kaempferia rotunda) Rhizome Extract Against HeLa Cervical Cancer Cell Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti cervical cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">in vitro</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia rotunda</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1297-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to compare between ethanol and ethyl acetate rhizome extract of &lt;em&gt;K.rotunda &lt;/em&gt;against HeLa cervical cancer cell &lt;em&gt;in vitro. &lt;/em&gt;&lt;strong&gt;Material and Methods: &lt;/strong&gt;Methods used in this research are test the chemical compound of extracts using Thin Layer Chromatography (TLC) and phytochemical screening test, also cytotoxicity test using MTT assay. &lt;strong&gt;Result:&lt;/strong&gt; Ethyl acetate extract contains flavonoid, alkaloid, tannin, and triterpenoid, while ethanol extract have flavonoid, triterpenoid, and alkaloid. In addition, ethanol extract has strong cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 16,939 μg/ml) while ethyl acetate extract has moderate cytotoxic activity (IC&lt;sub&gt;50&lt;/sub&gt; = 127,9 μg/ml). Each of extracts showed significant results (p ≤ 0,05) although when compared between concentrations there are several concentrations that are not significant and also small coefficient of determinant values caused by various confounding factors. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of &lt;em&gt;K.rotunda &lt;/em&gt;rhizome extract has the higher cytotoxicity activity compared to ethyl acetate extract of&lt;em&gt; K.rotunda&lt;/em&gt; rhizome extract against HeLa cervical cancer cell.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1297</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Surya Dwira&lt;sup&gt;1&lt;/sup&gt;, Ariska TP&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,3,&lt;/sup&gt;*, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Linda Erlina&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Iman AA Kassem</style></author><author><style face="normal" font="default" size="100%">Ayman A Farghaly</style></author><author><style face="normal" font="default" size="100%">Neveen S Ghaly</style></author><author><style face="normal" font="default" size="100%">Zeinab M Hassan</style></author><author><style face="normal" font="default" size="100%">Marian Nabil</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Composition and Genoprotective Effect of the Flavonoidal Content of Lepidium sativum L. Methanolic Seed Extract against Cyclophosphamide- Induced DNA Damage in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromosomal abberations</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipidium sativum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">124-130</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Lepidium sativum&lt;/em&gt; L. (Family Brassicaceae) is known to possess different pharmacological properties. &lt;strong&gt;Objective: &lt;/strong&gt;The genoprotective role of flavonoids of &lt;em&gt;L. sativum &lt;/em&gt;methanolic seed extract (LSF) against cyclophosphamide (CP)-induced DNA damage, in somatic and germ cells of mice, as well as characterization of the flavonoidal content were carried out in this study. Chromosomal aberration analysis in somatic and germ cells were also included. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Six mice groups were used for this study. Group 1 served as a negative control. Group 2 received oral LSF (100 mg/kg b.wt.) for 5 consecutive days. Group 3 served as a positive control by receiving a single intraperitoneal (i.p.) CP dose (20 mg/kg b.wt.). The three other groups were orally administered 25, 50 and 100 mg/kg b.wt. LSF, respectively, for 5 consecutive days. On the last day of treatment, the three groups received i.p. injection of CP (20 mg/kg b.wt.). Flavonoids were identified using spectral analysis.&lt;strong&gt; Results: &lt;/strong&gt;LSF inhibited DNA aberrations in mice caused by cyclophosphamide dose dependently in the three groups with significant difference in the two groups that received doses of 50 and 100 mg/kg b.wt. The chromosomal aberrations inhibitory indices were calculated as 18 and 31 in mice somatic cells and 27 and 48 in germ cells, respectively. LSF was found to contain the flavonoids kaempferol, quercetin, kaempferol-3-O-α-L-rhamnopyranoside, kaempferol-3-O-β-D-glucopyranoside, and quercetin-3-O-β-D-galactopyranoside. &lt;strong&gt;Conclusion: &lt;/strong&gt;LSF inhibited the DNA damage induced by CP in somatic and germ cells of mice dose-dependently. The antioxidant properties associated with flavonoids might account for the genoprotective activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">124</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Iman AA Kassem&lt;sup&gt;1,&lt;/sup&gt;*, Ayman A Farghaly&lt;sup&gt;2&lt;/sup&gt;, Neveen S Ghaly&lt;sup&gt;1&lt;/sup&gt;, Zeinab M Hassan&lt;sup&gt;1&lt;/sup&gt;, Marian Nabil&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Chemistry of Natural Compounds Department, National Research Centre, Dokki 12622, Giza, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Genetics and Cytology Department, National Research Centre, Dokki 12622, Giza, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Serigne Ibra Mbacké DIENG</style></author><author><style face="normal" font="default" size="100%">Céline Mathieu</style></author><author><style face="normal" font="default" size="100%">Abdou SARR</style></author><author><style face="normal" font="default" size="100%">Kady Diatta-Badji</style></author><author><style face="normal" font="default" size="100%">Alioune Dior FALL</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Condensed Tannins Content and their Influence on the Antioxidant Activity of Bark Hydroethanol Extract of Piliostigma reticulatum (Dc) Hochst and its Fractions</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Bark</style></keyword><keyword><style  face="normal" font="default" size="100%">Piliostigma reticulatum</style></keyword><keyword><style  face="normal" font="default" size="100%">Precipitation</style></keyword><keyword><style  face="normal" font="default" size="100%">Tannins</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">361-368</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Consumption of natural products from plants is implicated in the reduction of the occurrence of diseases related to oxidative stress. &lt;em&gt;Piliostigma reticulatum&lt;/em&gt; is a plant well known to traditional practitioners in Senegal where leaves and bark are often used against many diseases, such as ulcers, boils, syphilitic cancer, toothache, gingivitis and diarrhea.&lt;strong&gt; Aim:&lt;/strong&gt; This study compared hydroethanol extract from the plant bark and its fractions by assessing their total phenol contents, antioxidant activity and the influence of condensed tannins on their activity. &lt;strong&gt;Method: &lt;/strong&gt;barks were extracted by a moderate decoction with ethanol-water followed by a silica column fractionation with successively ethyl acetate, methanol and water. For this study, assays were carried out before and after precipitation of tannins by BSA and PVPP tests. Total phenol and condensed tannins of hydroethanolic extract and its fractions were performed by Folin Ciocalteu and hydrolysis methods. Antioxidant activity was evaluated by DPPH and CUPRAC tests. &lt;strong&gt;Results: &lt;/strong&gt;Tannins precipitation leads a light decrease of total phenol and condensed tannins contents of samples. Total phenol content of hydroethanolic extract was 51.2 mg GAE/g vs 3.2 after BSA test and 1.7 after PVPP test whereas condensed tannins content obtained 72.2% vs 4.2% and 2.3% after precipitation. Antiradical activity was lost following the elimination of tannins with IC&lt;sub&gt;50&lt;/sub&gt;: 5.33 ± 0.04 mg/l vs 78.86 ± 0.92 after BSA and &amp;gt; 500 after PVPP.&lt;strong&gt; Conclusion:&lt;/strong&gt; This results showed the condensed tannins would be in charge of antiradical and reducing activities of plant barks and PVPP precipitated much better the tannins from those extracts than BSA.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">361</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Serigne Ibra Mbacke DIENG&lt;sup&gt;1,&lt;/sup&gt;*, Céline Mathieu&lt;sup&gt;2,3&lt;/sup&gt;, Abdou Sarr&lt;sup&gt;1&lt;/sup&gt;, Kady Diatta-Badji&lt;sup&gt;1&lt;/sup&gt;, Alioune Dior Fall&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy and Botany, Cheikh Anta Diop University, Dakar, SENEGAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Agro-Industrial Chemistry, LCA, University of Toulouse, INRA, Toulouse, FRANCE.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Center of Application and treatment of Agro-Ressources (CATAR), INP, Toulouse, FRANCE.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">NadzilaAnindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Rista Putrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity of Soursop Leaves (Annona muricata) against Cervical HeLa Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Soursop</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cervical cancer is the cancer with highest prevalence and the leading cause of women death in Indonesia. Current treatments available for cervical cancer are chemotherapy, radiation, surgery, and nuclear therapy. Unfortunately, these treatments still have several limitations due to serious side effects, development of resistance, and very expensive price. Therefore, it is necessary to develop effective and low-cost therapy to treat cervical cancer. One of which is by utilizing natural sources available in Indonesia such as soursop (&lt;em&gt;Annona muricata&lt;/em&gt;) leaves which has been used in folk medicine as a treatment for various diseases, including cancer. However, studies about its cytotoxicity against cervical cancer in Indonesia are still limited. &lt;strong&gt;Objective: &lt;/strong&gt;The aim of this research is to analyze the potency of &lt;em&gt;A.muricataleaves&lt;/em&gt; extracts originated from Indonesia as a novel alternative treatment for cervical cancer. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;&lt;em&gt;A.muricata&lt;/em&gt; leaves obtained from Serpong, West Java, Indonesia were grounded and macerated in three different solvents with various polarity, namely ethanol (polar solvent), ethyl acetate (semipolar solvent) and hexane (non-polar solvent). Subsequently, the extracts were diluted into 8 various concentrations. Cytotoxicity of &lt;em&gt;A.muricataleaves &lt;/em&gt;extracts against HeLa cervical cancer cells were determined by MTT assay and expressed by IC&lt;sub&gt;50 &lt;/sub&gt;value.&lt;strong&gt; Results: &lt;/strong&gt;The results showed that three extracts of &lt;em&gt;A.muricata&lt;/em&gt; have strong cytotoxicity against cervical HeLa cells. The highest cytotoxic activity was shown by etanol extract with an IC&lt;sub&gt;50&lt;/sub&gt; of 35.51 μg/mL, followed by ethyl acetate (IC&lt;sub&gt;50&lt;/sub&gt;: 5.91 μg/mL), and hexane (IC&lt;sub&gt;50&lt;/sub&gt;: 8.39 μg/mL). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;A.muricata &lt;/em&gt;leaves extracts are potential to be developed as a novel alternative therapy for cervical cancer.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, NadzilaAnindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;, Rista Putrianingsih&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Monika Bhalodiya</style></author><author><style face="normal" font="default" size="100%">Jayant Chavda</style></author><author><style face="normal" font="default" size="100%">Nilesh Patel</style></author><author><style face="normal" font="default" size="100%">Ravi Manek</style></author><author><style face="normal" font="default" size="100%">Ajay Patel</style></author><author><style face="normal" font="default" size="100%">Sheetal Faldu</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Determination of Polyphenolic content and Antioxidant Activity from Various Extracts of Boerhaavia diffusa Linn Root: An in vitro Approach for Selection of Appropriate Extracting Solvent</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">ABTS</style></keyword><keyword><style  face="normal" font="default" size="100%">Boerhavia diffusa</style></keyword><keyword><style  face="normal" font="default" size="100%">crude extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Free radicles</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1578-1585</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study is aimed to evaluate extraction capacity of different solvents (toluene, dichloromethane, chloroform, ethyl acetate, ethanol, methanol, water, 60% aqueous methanol, 60% aqueous ethanol and 60% aqueous acetone) and its effect on total phenolic content, total flavonoid content, and antioxidant assay. &lt;strong&gt;Methods: &lt;/strong&gt;Extraction was performed from dried root powder of &lt;em&gt;Boerhavia diffusa&lt;/em&gt; using various solvents at 25˚C on magnetic sirr (300 rpm). Extraction yield, total phenolic content, total flavonoid content and total tannin content of the extracts were determined spectrophotometrically using gallic acid, quercetin as standards. Antioxidant potential determines by using various in vitro methodologies such as DPPH, FRAP, and ABTS assay. &lt;strong&gt;Result: &lt;/strong&gt;The 60% aqueous methanol showed the highest extracting yield, in contrast, toluene and hexane showed the lowest yield. Highest total phenolic content (239.8±0.25 mg GAE/g) and total flavonoid content (131.1±4.20 mg QCE/g), were found from methanolic extract. While, acetone extract showed highest tannin content. The Methanolic extract of &lt;em&gt;Boerhaavia diffusa&lt;/em&gt; exhibited the highest antioxidant activity. &lt;strong&gt;Conclusions: &lt;/strong&gt;The highest correlation was found between phenolic content and the antioxidant assay. It seems that phenolic contents are responsible for free radicle scavenging activity. From the observation, it concluded that methanolic extract rich with polyphenolic content and acetone extract showed the highest amount of tannin content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1578</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Monika Bhalodiya&lt;sup&gt;1,&lt;/sup&gt;*, Jayant Chavda&lt;sup&gt;2&lt;/sup&gt;, Nilesh Patel&lt;sup&gt;2&lt;/sup&gt;, Ravi Manek&lt;sup&gt;2&lt;/sup&gt;, Ajay Patel&lt;sup&gt;2&lt;/sup&gt;, Sheetal Faldu&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Gujarat Technological University, Chandkheda, Ahmedabad, Gujarat 382424, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;B.K Mody Government Pharmacy College, Rajkot, Gujarat 360003, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Smt. R. D. Gardi B. Pharmacy College, Rajkot 360005, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pornpun Laovachirasuwan</style></author><author><style face="normal" font="default" size="100%">Wutthichart Fuangbangluang</style></author><author><style face="normal" font="default" size="100%">Atchariyaporn Phanichanaphan</style></author><author><style face="normal" font="default" size="100%">Issarapong Nasomroop</style></author><author><style face="normal" font="default" size="100%">Methin Phadungkit</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Development of Phyllanthus emblica Extract in Ethosomes for Hair Loss Prevention</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Entrapment efficiency</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethosomes</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus emblica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">905-910</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Hair loss is not a serious health problem but leads to decreased self- confidence, personality, and psychological problems. According to Thai traditional medical wisdom, &lt;em&gt;Phyllanthus emblica &lt;/em&gt;has the property to prevent hair loss. Ethosomes are a drug delivery system, which can increase drug delivery to deep skin layers and enhance the effectiveness of the active ingredient.&lt;strong&gt; Objective: &lt;/strong&gt;This research aims to develop ethosomes of &lt;em&gt;Phyllanthus emblica&lt;/em&gt; extract with beneficial properties. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;Phyllanthus emblica&lt;/em&gt; was extracted by a maceration method with 95% ethanol as a solvent. The total phenolic content of the extracts was determined using the Folin-Ciocalteu method. The antioxidation activity was evaluated by DPPH assay. Ethosomes were formulated by a cold method and their properties were observed. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that the total phenolic content of &lt;em&gt;Phyllanthus emblica &lt;/em&gt;extract was 406.37±2.39 mg GAE/g extract. The IC&lt;sub&gt;50&lt;/sub&gt; of antioxidant activity was 7.05±0.17 μg/ml. Ethosomes with 0.03% of &lt;em&gt;Phyllanthus emblica &lt;/em&gt;extract, 2% of soya phosphatidylcholine, and 20% of ethanol had the highest percentage of entrapment efficiency (65.26%±1.80%). The ethosomes of &lt;em&gt;Phyllanthus emblica &lt;/em&gt;extract was the spherical shape and white colloid. The particle size, polydispersity index, zeta potential, and pH of ethosomes were 0.43±0.00 μm, 0.44±0.03, -10.40±0.28 mV, and 4.06±0.03, respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethosomes of &lt;em&gt;Phyllanthus emblica&lt;/em&gt; extract had good properties and area possible alternative product for hair loss prevention.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">905</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pornpun Laovachirasuwan*, Wutthichart Fuangbangluang, Atchariyaporn Phanichanaphan, Issarapong Nasomroop, Methin Phadungkit &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Mahasarakham University, Kantarawichai District, Mahasarakham 44150, THAILAND&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Roger Ducos Youmsi Fokouo</style></author><author><style face="normal" font="default" size="100%">Patrick Valere Tsouh Fokou</style></author><author><style face="normal" font="default" size="100%">Cedric Derick Jiatsa Mbouna</style></author><author><style face="normal" font="default" size="100%">Elisabeth Zeuko’o Menkem</style></author><author><style face="normal" font="default" size="100%">Fabrice Fekam Boyom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Formulation and Evaluation of Safety and Antifungal Efficacy of Syzigium Aromaticum-Base Cream on Guinea Pigs Infected with Trichophyton Mentagrophytes</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidermatophytes activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Dermatophytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Formulation</style></keyword><keyword><style  face="normal" font="default" size="100%">S. aromaticum</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">342-350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The increasing incidence of dermatophytoses in the world and the side effects of the current therapies encouraged the search of alternative drugs. Hence the objective of this work was to determine antidermatophytes activity of &lt;em&gt;Syzigium aromaticum&lt;/em&gt; formulate antidermatophytic cream. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The extracts were prepared by maceration of plant materials into methanol. Three formulations of creams were made, and the best was chosen according to its physicochemical stability and appearance. The acute dermal toxicity and antidermatophytic efficacy of the cream was performed on guinea-pig. &lt;strong&gt;Results: &lt;/strong&gt;The methanolic extract of &lt;em&gt;S. aromaticum &lt;/em&gt;was incorporated in the final cream formulation. The formulation containing shea-butter 58.5%, acetylic alcohol 2.5%, stearic acid 1.5%, bee-wax 10%, borax 1.5%, polysorbate 60 2.5%, 2 drops of lactic acid and water was chosen because of its good appearance and stability. The cream with methanolic extract of&lt;em&gt; S. aromaticum &lt;/em&gt;did not reveal any dermal toxic effect. The cream efficacy was dose-dependent. The treatment with cream at 5% methanolic extracts of &lt;em&gt;S. aromaticum&lt;/em&gt; revealed the best potency after 14 days of treatment. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results show that the cream at 5% methanolic extract of &lt;em&gt;S. aromaticum&lt;/em&gt; seed is promising in the treatment of dermatophytoses and could be used as an alternative in the development of a new therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">342</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Roger Ducos Youmsi Fokouo&lt;sup&gt;1,2&lt;/sup&gt;, Patrick Valere Tsouh Fokou&lt;sup&gt;1,2,3,&lt;/sup&gt;*, Cedric Derick Jiatsa Mbouna&lt;sup&gt;1&lt;/sup&gt;, Elisabeth Zeuko’o Menkem&lt;sup&gt;1,4&lt;/sup&gt;, Fabrice Fekam Boyom&lt;sup&gt;1,2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Antimicrobial and Biocontrol Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Study, Faculty of Science, University of Yaoundé 1, PO Box 812, Yaoundé, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Discovery and Development Unit, Laboratoire Roger Ducos, PO Box 20133, Yaounde, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, University of Bamenda, PO Box 39, Bambili, CAMEROON.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, University of Buea, PO Box 63, Buea, CAMEROON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Desdiani Desdiani</style></author><author><style face="normal" font="default" size="100%">Iris Rengganis</style></author><author><style face="normal" font="default" size="100%">Samsuridjal Djauzi</style></author><author><style face="normal" font="default" size="100%">Agus Setiyono</style></author><author><style face="normal" font="default" size="100%">Mohamad Sadikin</style></author><author><style face="normal" font="default" size="100%">Sri Widia A Jusman</style></author><author><style face="normal" font="default" size="100%">Nuryati Chairani Siregar</style></author><author><style face="normal" font="default" size="100%">Suradi</style></author><author><style face="normal" font="default" size="100%">Putri C Eyanoer</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Assay and Study Interaction of Uncaria gambir (Hunter) Roxb. as Anti-fibrotic Activity Against A549 Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gambiriin compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibitor of p50 NF-κB</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Pulmonary fibrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">TGF-β1 receptors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1232-1240</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to finding inhibitor potential from several compounds in gambir plant by using&lt;em&gt; in vitro&lt;/em&gt; MTT assay and study interaction with molecular docking. The interaction of amino acids on the binding site with substances in the gambir plant was analyzed to determine its potential as a herbal-based therapy candidate for pulmonary fibrosis. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Protein target using TGFβ1 and NF-κB and compounds from gambir plant ((+)-Catechin. Epigallocatechin gallate, (+)-Epicatechin, Gambiriin A1, Gambiriin A2, Gambiriin B1, Gambiriin B2, Gambiriin C, Procyanidin B1, Procyanidin B3). &lt;strong&gt;Result:&lt;/strong&gt; The results from docking analysis observed that compounds from gambir fruit contain anti-fibrotic activity which act by inhibiting DNA transcription of NF-κB and TGF-β1receptors. The compound Procyanidin B3, an essential amino acid, contains a hydrogen bond with the greatest NF-κB inhibitory activity on Gly214 and Lys337. Compounds from&lt;em&gt; Uncaria gambir &lt;/em&gt;(Hunter) Roxb. can be an inhibitor to TGFβ1, all the compounds are on the active site of TGFβ1, and use native ligand which is an inhibitor of TGFβ1 (Naphtyridine). The positive compound catechin has the highest inhibitory activity. Gambiriin B1 and Gambiriin A2 are the most identical compounds with similar affinity binding value. &lt;em&gt;Uncaria gambir&lt;/em&gt; (Hunter) Roxb. is already a proven antifibrotic which is further confirmed by (IC&lt;sub&gt;50&lt;/sub&gt;: 19,255 ± 1.08 μg/ml, p &amp;lt; 0.05) in A549 cell line. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results demonstrated that Gambiriin have cytotoxic effects and was found potentially as anti-fibrotic by MTT assay and in silico evaluation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1232</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Desdiani Desdiani&lt;sup&gt;1,&lt;/sup&gt;*, Iris Rengganis&lt;sup&gt;2&lt;/sup&gt;, Samsuridjal Djauzi&lt;sup&gt;2&lt;/sup&gt;, Agus Setiyono&lt;sup&gt;3&lt;/sup&gt;, Mohamad Sadikin&lt;sup&gt;4&lt;/sup&gt;, Sri Widia A. Jusman&lt;sup&gt;4&lt;/sup&gt;, Nuryati Chairani Siregar&lt;sup&gt;5&lt;/sup&gt;, Suradi&lt;sup&gt;6&lt;/sup&gt;, Putri C. Eyanoer&lt;sup&gt;7&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;8,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Universitas Sultan Ageng Tirtayasa, Cilegon, Banten, Indonesia&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Veterinary Medicine IPB, Bogor, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department Anatomical Pathology, Faculty of medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Pulmonology and Respiratory Medicine, Faculty of medicine, Universitas Sebelas Maret, Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Community and Preventive Medicine, Universitas Sumatera Utara&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Department of Medical Chemistry, Faculty of medicine, University of Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute (IMERI), Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Gerry Kurniawan</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Cytotoxicity of Hibiscus sabdariffa Linn Extracts on A549 Lung Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">A549 Lung Cancer Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Hibiscus sabdariffa Linn</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">14-19</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Lung cancer is the one of the leading causes of cancer death. However, current treatments for lung cancer are expensive and show negative side effects. Therefore, the study concerning natural anticancer from plants has intensified. &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn are Indonesian herb plants which have been consumed as a drink, are known to have anticancer activity against several cancer cell lines. However, its potential cytotoxic activity on A549 lung cancer cell line is still unclear. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to identify cytotoxic activity of &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn extracts on A549 lung cancer cell line. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;&lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn flowers from Tangerang, province of Banten, Indonesia, were macerated in three different solvents: ethyl acetate, ethanol, and n-hexane. Afterwards, cytotoxic activity of &lt;em&gt;Hibiscus sabdariffa &lt;/em&gt;Linn extracts on A549 lung cancer cell line were evaluated using MTT assay. There were eight variety of concentration of the extracts, the experiment has been done triplicate for each concentration. The anticancer activity is expressed by IC&lt;sub&gt;50&lt;/sub&gt; value. &lt;strong&gt;Results: &lt;/strong&gt;&lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn extracts in ethanol, ethyl acetate, and n-hexane showed IC&lt;sub&gt;50&lt;/sub&gt; value of 374.01 μg/mL, 719.28 μg/mL, and 906.57 μg/mL respectively, in which indicated weak cytotoxic activity on A549 lung cancer cell line. &lt;strong&gt;Conclusion:&lt;/strong&gt; Ethanol, ethyl acetate, and n-hexane extracts of &lt;em&gt;Hibiscus sabdariffa&lt;/em&gt; Linn are potential to be further developed as natural anticancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">14</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Qotrunnada Fithrotunnisa&lt;sup&gt;1&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2,3,&lt;/sup&gt;*, Gerry Kurniawan&lt;sup&gt;1&lt;/sup&gt;, Fona Qorina&lt;sup&gt;1&lt;/sup&gt;, Nadzila Anindya Tejaputri&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical Student, Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Cluster, Drug Discovery Division, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Qamariah</style></author><author><style face="normal" font="default" size="100%">Dewi Sari Mulia</style></author><author><style face="normal" font="default" size="100%">Denny Fakhrizal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Indigenous Knowledge of Medicinal Plants by Dayak Community in Mandomai Village, Central Kalimantan, Indonesia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Central Kalimantan</style></keyword><keyword><style  face="normal" font="default" size="100%">Dayak community</style></keyword><keyword><style  face="normal" font="default" size="100%">Indigenous knowledge</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">386-390</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Dayak community has a long history of using medicinal plants as traditional medicine. But this knowledge is conveyed verbally without any written documentation. Therefore, this study aim is to preserve Dayak`s knowledge about medicinal plants in Mandomai village. &lt;strong&gt;Methods:&lt;/strong&gt; To collect the information, a survey was conducted in January 2019. &lt;em&gt;Snowball&lt;/em&gt; sampling method was utilized to select 11 informants. Data were collected using structured interviews to gather information about local names, part of plants, the benefit of plants and how the plants are used. &lt;strong&gt;Results: &lt;/strong&gt;The result showed that 55 species of medicinal plants used by the Dayak community in Mandomai as traditional medicine. However, only 48 species were identified, while 7 others were still in the process of being identified. The most widely used part of the plants is the leaves. Before being used as traditional medicine, medicinal plants are processed first. Some plants are ground and used immediately, while some are boiled or soaked in warm water.&lt;strong&gt; Conclusion: &lt;/strong&gt;This documentation provides a catalog of medicinal plants used by Dayak community for the education of future indigenous knowledge&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">386</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurul Qamariah*, Dewi Sari Mulia, Denny Fakhrizal &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, Universitas Muhammadiyah Palangkaraya, Palangka Raya, Central Kalimantan, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Joko Wahyuwibowo</style></author><author><style face="normal" font="default" size="100%">Abdul Aziz</style></author><author><style face="normal" font="default" size="100%">Eka Safitri</style></author><author><style face="normal" font="default" size="100%">Minidian Fasitasari</style></author><author><style face="normal" font="default" size="100%">Siti Thomas Zulaikhah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Iron-Folate Supplementation during Pregnancy for Prevent Oxidative Stress in Pregnant Rats: Level of MDA, Creatinine, Glucose, Erythrocite, Blood Pressure, Body Weight and Number of Offspring</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Folic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">186-191</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Iron and folic acid deficiency during pregnancy can increase oxidative stress and result in impaired intra-uterine growth, abortion and preeclampsia. Folate is trace nutrient that influent for essential role for epigenetic mechanism cues into changes in gene expression and had impact health development. This study aimed to determine the effect of several doses of iron and folate supplementation on level of: MDA, glucose, creatinine, maternal body weight and number and birth weight of offspring. &lt;strong&gt;Methods: &lt;/strong&gt;This research was conducted in the laboratory of the Center for Food and Nutrition Studies, Gadjah Mada University Yogyakarta. Experimental research with posttest only control group design with a number of samples: 20 pregnant rats, divided randomly into 4 groups. The control group (C) was given standard feed (AIN-93G), KI: added iron 1,8 mg/200gBW and folic acid 0,0023mg/200gBW, KII: added iron 3,6 mg/200gBB and folic acid 0,0045 mg/200gBW, KIII : added iron 5,4mg/200gBW and folic acid 0,0068 mg/200gBW. Duration of treatment 20 days. Measurement of body weight, blood pressure and then taken blood samples at the 21&lt;sup&gt;st&lt;/sup&gt; day for examination of MDA, glucose, creatinine, erythrocyte level. Sectio caesarean to performed the number and body weight of offspring. Data obtained were analyzed using one way Anova followed by Post hoc LSD. &lt;strong&gt;Results: &lt;/strong&gt;there are significant different (&lt;em&gt;p &lt;/em&gt;&amp;lt;0.001). on level of : MDA, glucose, creatinine, maternal body weight, average number and fetal weight of offspring between treatment group compare to control group. &lt;strong&gt;Conclusion:&lt;/strong&gt; Iron and folate suplementation during pregnancy can decreased level of oxidative stress and better pregnant outcome.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">186</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Joko Wahyuwibowo&lt;sup&gt;1&lt;/sup&gt;, Abdul Aziz&lt;sup&gt;2&lt;/sup&gt;, Eka Safitri&lt;sup&gt;2&lt;/sup&gt;, Minidian Fasitasari&lt;sup&gt;1&lt;/sup&gt;, Siti Thomas Zulaikhah&lt;sup&gt;3,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Nutrition Faculty of Medicine Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Student Faculty Of Medicine Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health Faculty of Medicine Sultan Agung Islamic University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Iman Nurul Fuad</style></author><author><style face="normal" font="default" size="100%">Mahendran Sekar</style></author><author><style face="normal" font="default" size="100%">Siew Hua Gan</style></author><author><style face="normal" font="default" size="100%">Pei Teng Lum</style></author><author><style face="normal" font="default" size="100%">Jaishree Vaijanathappa</style></author><author><style face="normal" font="default" size="100%">Subban Ravi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Lutein: A Comprehensive Review on its Chemical, Biological Activities and Therapeutic Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Inflammatory cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Lutein</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular targets</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacology</style></keyword><keyword><style  face="normal" font="default" size="100%">Transcription factors</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1769-1778</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Lutein is a naturally occurring carotenoid found in high amounts in flowers, grains, fruits and green vegetables with green leaves include spinach, kale and carrots. The market for lutein encompasses pharmaceutical, dietary supplement, food, animal and fish feed industries. &lt;strong&gt;Objective: &lt;/strong&gt;The present review aimed to provide an updated and comprehensive analysis of lutein, including its chemistry, biological properties and therapeutic potentials. &lt;strong&gt;Methods:&lt;/strong&gt; Relevant literatures were collected from several scientific databases, include Google Scholar, Pubmed and ScienceDirect between 2000 to till date. Following a detailed inclusion and exclusion screening process, the information obtained was summarized. &lt;strong&gt;Results: &lt;/strong&gt;Information on the sources, chemistry and biological properties including antioxidant, anti-arthrisits, antiinflammatory, hepatoprotective, cardioprotective, anti-cataract, antidiabetic, anticancer and bone remodelling activities, as well as food industry processing for lutein were tabled. Lutein can be considered powerful antioxidants along with multifaceted molecular targets, such as NF-ҡB, PI3K/Akt, Nrf‑2, HO-1 and SIRT-1 signaling pathways in various pathological conditions. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present review observe the chemical, pharmacological properties, in addition to the therapeutic potentials of lutein. It is hoped that the information can provide a good reference to aid in the development and utilization of lutein in phytopharmaceuticals and food industries.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1769</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Nurul Iman Nurul Fuad&lt;sup&gt;1&lt;/sup&gt;, Mahendran Sekar&lt;sup&gt;1,&lt;/sup&gt;*, Siew Hua Gan&lt;sup&gt;2&lt;/sup&gt;, Pei Teng Lum&lt;sup&gt;1&lt;/sup&gt;, Jaishree Vaijanathappa&lt;sup&gt;3&lt;/sup&gt;, Subban Ravi&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Health Sciences, Universiti Kuala Lumpur Royal College of Medicine Perak, Ipoh – 30450, Perak, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Selangor Darul Ehsan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru – 570015, JSS Academy of Higher Education and Research, Mysuru, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore – 640 021, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Risya Amelia Rahmawanti</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Brenda Cristie Edina</style></author><author><style face="normal" font="default" size="100%">Lowilius Wiyono</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nanoparticle Synthesis and Cytotoxicity of Kaempferia pandurata Roxb. Extract to the Growth of MDA-MB-231 Breast Cancer Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Kaempferia pandurata Roxb.</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Temu Kunci</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">109-114</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Breast cancer is the most common cancer worldwide and in Indonesia. &lt;em&gt;Kaempferia pandurata &lt;/em&gt;Roxb. is a herbal plant from South-East Asia which is known for its ability to inhibit the growth of Estrogen Receptor (ER) + breast cancer cell line from the former study. However, its effect on ER- breast cancer cell lines had not been studied. Therefore, we want to examine the cytotoxicity effect of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. on ER- breast cancer cell line (MDA-MB-231). Nanoparticle is a form of preparation that optimizes the activity of any compound to the targeted cell. Therefore, it is expected that it can increase the effectivity of anticancer in &lt;em&gt;Kaempferia pandurata&lt;/em&gt; Roxb. In this study, the rhizome of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. trituration was dried and extracted with n-hexane solvent. Nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. was synthesized with CaCl&lt;sub&gt;2&lt;/sub&gt;, chitosan, and alginate by stirring with a magnetic stirrer, adjusting pH, and centrifugation. Then, nanoparticle was analized by UV/VIS spectrofotometry and transmission electron microscopy (TEM). The cytotoxicity of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract and nanoparticle were examined with MTT assay. The result of this test is data of inhibition percentage and IC&lt;sub&gt;50&lt;/sub&gt; value. The result showed that n-hexane extract of &lt;em&gt;K. pandurata &lt;/em&gt;Roxb. is synthesized into nanoparticle form with 99,43% yield percentage (entrapment value). Anticancer activity of n-hexane extract and nanoparticle of&lt;em&gt; K. pandurata&lt;/em&gt; Roxb. is moderate with IC&lt;sub&gt;50&lt;/sub&gt; value of the extract is 87,23 μg/ml and the nanoparticle is 24,23 μg/ml. The nanoparticle’s activity is better than the extract. n-Hexane extract and nanoparticle of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. has cytotoxicity effects towards MDA-MB-231 cell line. Nanoparticle can increase the cytotoxicity effect of &lt;em&gt;K. pandurata&lt;/em&gt; Roxb. extract because its hydrophobic feature and nanometer size.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">109</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Risya Amelia Rahmawanti&lt;sup&gt;1&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2,3,&lt;/sup&gt;*, Brenda Cristie Edina&lt;sup&gt;1&lt;/sup&gt;, Lowilius Wiyono&lt;sup&gt;1&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Undergraduate Medical Student, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine University of Indonesia, Jalan Salemba Raya No.6, Jakarta Pusat, 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Drug Development Research Center – IMERI, Faculty of Medicine University of Indonesia, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amr A Fouad</style></author><author><style face="normal" font="default" size="100%">Entesar F Amin</style></author><author><style face="normal" font="default" size="100%">Amira F Ahmed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Naringenin and Vanillin Mitigate Cadmium-Induced Pancreatic Injury in Rats via Inhibition of JNK and p38 MAPK Pathways</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">CdCl2</style></keyword><keyword><style  face="normal" font="default" size="100%">JNK/MAPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringenin</style></keyword><keyword><style  face="normal" font="default" size="100%">p38/MAPK</style></keyword><keyword><style  face="normal" font="default" size="100%">Pancreas</style></keyword><keyword><style  face="normal" font="default" size="100%">Vanillin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">742-748</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Cadmium can induce pancreatic injury via oxidative stress, inflammation and apoptosis. Naringenin (NGN) and vanillin (VLN) exert antioxidant, anti-inflammatory, and antiapoptotic effects. &lt;strong&gt;Objective: &lt;/strong&gt;The likely ameliorative effects of NGN, VLN and their combination were studied in rats exposed to cadmium-induced pancreatic injury. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Rats received NGN (50 mg/kg/day, p.o.), VLN (100 mg/ kg/day, p.o.), or NGN + VLN for 7 days and one injection of CdCl&lt;sub&gt;2&lt;/sub&gt; (2 mg/kg, i.p.) on the 6&lt;sup&gt;th&lt;/sup&gt; day. &lt;strong&gt;Results:&lt;/strong&gt; Cadmium significantly lowered serum amylase and insulin levels. Cadmium also caused significant increments of malondialdehyde, tumor necrosis factor-α, interleukin-1β, nuclear factor-κB p65, Bax/Bcl-2 ratio and phosphorylated c-Jun N-terminal kinase (p-JNK) and p38 mitogen-activated protein kinases (MAPKs) and significant decrements of reduced glutathione and catalase in the pancreas of rats received CdCl&lt;sub&gt;2&lt;/sub&gt;. Additionally, CdCl&lt;sub&gt;2&lt;/sub&gt; caused marked histopathological necrosis and significantly increased caspase-3 expression in pancreatic tissue. The cadmium-induced biochemical, histopathological and immunohistochemical changes were significantly ameliorated by NGN, VLN and NGN + VLN. However, NGN + VLN caused more significant ameliorative effects than did NGN and VLN alone. &lt;strong&gt;Conclusion: &lt;/strong&gt;NGN, VLN and NGN + VLN afforded significant protection of pancreas in rats exposed to cadmium insult through modulation of JNK and p38 MAPK pathways and inhibition of oxidative stress, inflammation and apoptosis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">742</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amr A Fouad&lt;sup&gt;1,2,&lt;/sup&gt;*, Entesar F Amin&lt;sup&gt;2&lt;/sup&gt;, Amira F Ahmed&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Al-Baha University, Al-Baha, SAUDI ARABIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Minia University, El-Minia, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Histology, Faculty of Medicine, Minia University, El-Minia, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rini Prastiwi</style></author><author><style face="normal" font="default" size="100%">Ema Dewanti</style></author><author><style face="normal" font="default" size="100%">Inka Nurul Fadliani</style></author><author><style face="normal" font="default" size="100%">Nessa Aqilla</style></author><author><style face="normal" font="default" size="100%">Salwaa Salsabila</style></author><author><style face="normal" font="default" size="100%">Vera Ladeska</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Nephroprotective And Antioxidant Activity of Sterculia rubiginosa Zoll. Ex Miq. Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Gentamicin</style></keyword><keyword><style  face="normal" font="default" size="100%">Nephroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Sterculia rubiginosa Zoll Ex. Miq.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">843-849</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Sterculia&lt;/em&gt; has an antioxidant activity. The &lt;em&gt;Sterculia &lt;/em&gt;genus has phenols and flavonoids content, and this chemical content may be have an nephroprotective activity. &lt;strong&gt;Objective: &lt;/strong&gt;The study was to investigate the &lt;em&gt;in vitro &lt;/em&gt;study of antioxidant activity with DPPH and FRAP study and nephroprotective activity of &lt;em&gt;Sterculia rubiginosa &lt;/em&gt;Zoll. Ex Miq. Leaves extract. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaves was extracted using ethanol. This extract was determined for antioxidant activity by &lt;em&gt;in vitro &lt;/em&gt;study with DPPH and FRAP methods, determined the content of total phenols, total flavonoids, and also identification of chemical content. Nephrotoxicity study done by induced gentamycin. The groups divided 6 group, consist: negative control, positive control, normal control, and the extract with dose 50 mg/kg, 100 mg/kg, and 200 mg/ kg. The parameter for nephroprotective activity was tubular necrosis, the presence of tubules casts and glomerular damage, creatinine serum, and urea. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extract has IC&lt;sub&gt;50 &lt;/sub&gt;162.34 μg/ml for DPPH scavenging activity and 18.65 ± 3.53 FeEAC (Mol/g) for FRAP. The secondary metabolite presence flavonoids, tannins, terpenes, alkaloids, and glycosides. The total phenols 462.36 ± 9.23 mg GAE/gr, total flavonoids content 59.44 ± 0.11 mg QE/gr extract. All the dose have an nephroprotective activity, but the best dose was 50 mg/kg. &lt;strong&gt;Conclusion: &lt;/strong&gt;The ethanol extract of &lt;em&gt;Sterculia rubiginosa&lt;/em&gt; showed antioxidant activity and nephroprotective activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">843</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rini Prastiwi&lt;sup&gt;1,&lt;/sup&gt;*, Ema Dewanti&lt;sup&gt;1&lt;/sup&gt;, Inka Nurul Fadliani&lt;sup&gt;2&lt;/sup&gt;, Nessa Aqilla&lt;sup&gt;2&lt;/sup&gt;, Salwaa Salsabila&lt;sup&gt;2&lt;/sup&gt;, Vera Ladeska&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy Universitas Muhammadiyah prof. Dr. HAMKA, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Onyekere Peculiar Feenna</style></author><author><style face="normal" font="default" size="100%">Odoh Uchenna Estella</style></author><author><style face="normal" font="default" size="100%">Peculiar-Onyekere Chioma Obianuju</style></author><author><style face="normal" font="default" size="100%">Nwafor Felix Ifeanyi</style></author><author><style face="normal" font="default" size="100%">Ezugwu Christopher Obodike</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharmacognostic and Phytochemical Studies of Leaves of Psydrax horizontalis Schum. and Thonn (Rubiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Psydrax horizontalis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">541-550</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Psydrax horizontalis &lt;/em&gt;Schum. and Thonn; is used traditionally in the treatment of malaria, fever, and management of diabetes in Nsukka, South-eastern Nigeria. Owing to its increasing ethno-medicinal relevance, proper identification and evaluation are vital to prevent adulteration. This research article presents a detailed pharmacognostic, physicochemical and phytochemical evaluation on the leaves of &lt;em&gt;Psydrax horizontalis&lt;/em&gt; which will be used in its identification and consequent standardization. &lt;strong&gt;Methods: &lt;/strong&gt;The fresh and powdered leaves were evaluated for their macroscopic and microscopic features. Physicochemical properties and phytochemical screening were carried out based on standard procedures by World Health Organization (WHO).&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Psydrax horizontalis &lt;/em&gt;is a petiolate, stipulate and compound bi-pinnate leaf with reticulate venation, entire margin, chordate base and has opposite leaf arrangement. Microscopic diagnostic characters observed were paracytic stomata, unicellular covering trichomes, microsphenoidal shaped calcium oxalate crystals, lignified vessels and fibres as well as numerous starch grains. The total ash, water soluble ash, sulphated ash, acid insoluble ash compositions were 6.5, 0.5, 2.75 and 0.5% respectively. The moisture content, alcohol soluble extractive and water soluble extractive values obtained were 8.8, 3.8 and 3.7% respectively. Qualitative and quantitative phytochemical screening showed flavonoids, tannins, steroids, phenols and alkaloids at 100.00±0.035, 22.00±0.036, 19.50±0.024, 15.00±0.032 and 13.00±0.014 mg/g respectively as the major phytochemical constituents. &lt;strong&gt;Conclusion:&lt;/strong&gt; The pharmacognostic standards of the leaves of &lt;em&gt;Psydrax horizontalis &lt;/em&gt;were determined and serve as quality control parameters for their purity, identification and standardization.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">541</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Onyekere Peculiar Feenna&lt;sup&gt;1,&lt;/sup&gt;*, Odoh Uchenna Estella&lt;sup&gt;1&lt;/sup&gt;, Peculiar-Onyekere Chioma Obianuju&lt;sup&gt;2&lt;/sup&gt;, Nwafor Felix Ifeanyi&lt;sup&gt;1&lt;/sup&gt;, Ezugwu Christopher Obodike&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Environmental Medicine, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, 410001, Enugu State, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Onyekere Peculiar Feenna</style></author><author><style face="normal" font="default" size="100%">Odoh Uchenna Estella</style></author><author><style face="normal" font="default" size="100%">Ezugwu Christopher Obodike</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis and Anti-diabetic Activity of Leaf extract of Psydrax horizontalis Schum and Thonn (Rubiaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan monohydrate</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">95-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Rubiacaeae is a large family of flowering plants of 630 genera with over 13000 species widely distributed in the tropical and warm regions of the world. The &lt;em&gt;Psydrax genus &lt;/em&gt;has been reported to have various pharmacological activities. Based on ethno-pharmacological information, &lt;em&gt;Psydrax horizontalis &lt;/em&gt;Schum. and Thonn. (Bridson) locally known as “&lt;em&gt;Akata-ike&lt;/em&gt;” in Nsukka is used in the management of diabetes in South-eastern Nigeria. However as at the time of this research, no previous work has been done to investigate its phytochemical constituents and anti-diabetic activity. &lt;strong&gt;Methods:&lt;/strong&gt; The methanol extract (ME) obtained by maceration was analysed for phytochemicals present using standard procedures. Alloxan monohydrate at 150 mg/Kg was used to induce diabetes. Acute toxicity test was done using the Lorke’s method. The normoglycemic and alloxan-induced groups of twenty animals each were treated orally with 100, 200 and 400 mg/Kg of ME; 5 mg/Kg of glibenclamide and 2 mL/kg of 3% Tween 80 as the controls. The fasting blood glucose concentrations were monitored at 0, 1, 3 and 6 h, as well as 1&lt;sup&gt;st&lt;/sup&gt;, 3&lt;sup&gt;rd&lt;/sup&gt; and 5&lt;sup&gt;th&lt;/sup&gt; day. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical screening revealed the presence of glycosides, alkaloids, tannins, flavonoids, steroids, saponins and terpenoids. Median lethal dose was greater than 5000 mg/kg. In the alloxan-induced diabetic rats, significant activity at &lt;em&gt;p&lt;/em&gt;&amp;lt;0.01 on the 6th hour was recorded at doses 100, 200 and 400 mg/Kg ME on day 3. &lt;strong&gt;Conclusion:&lt;/strong&gt; The ME of &lt;em&gt;Psydrax horizontalis&lt;/em&gt; possesses significant anti-diabetic activity in the alloxan-induced diabetic rats. The results obtained validate its traditional use in management of diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">95</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Onyekere Peculiar Feenna&lt;sup&gt;1,2,&lt;/sup&gt;*, Odoh Uchenna Estella&lt;sup&gt;1&lt;/sup&gt;, Ezugwu Christopher Obodike&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy and Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka. 410001. Enugu State, Nigeria.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Health Sciences, Hamburg University of Apllied Sciences, HAWHamburg, Germany.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Vincent Kharisma Wangsaputra</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Wilzar Fachri</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author><author><style face="normal" font="default" size="100%">Hiroki Tanimoto</style></author><author><style face="normal" font="default" size="100%">Kiyomi Kakiuchi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Composition and Evaluation of Marine Algal Sargassum polycystum for Antioxidant Activity and In Vitro Cytotoxicity on Hela Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cells</style></keyword><keyword><style  face="normal" font="default" size="100%">phytochemisty</style></keyword><keyword><style  face="normal" font="default" size="100%">Sargassum polycystum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">88-94</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Sargassum polycystum&lt;/em&gt; is one of marine algal which has a potent antioxidant anticancer activities. This research aims to investigate phytochemical composition, antioxidant activity and &lt;em&gt;in vitro &lt;/em&gt;cytotoxicity of marine algal &lt;em&gt;Sargassum polycystum &lt;/em&gt;on cervical HeLa cancer.&lt;strong&gt; Methods:&lt;/strong&gt; &lt;em&gt;Sargassum polycystum&lt;/em&gt; collected from Dompu beach, Lombok, Nusa Tenggara Barat Province, Indonesia, were extracted into organic solvent of n-hexane, ethylacetate, chloroform and ethanol, respectively. Subsequently, &lt;em&gt;Sargassum polycystum&lt;/em&gt; extracts were applied for Thin Layer Chromatography (TLC) analysis, phytochemistry test, total phenolic and total flavonoid contents, as well as for antioxidant activity test by DPPH (2,2-diphenyl-1-picrylhydrazyl) method, and in vitro cytotoxicity evaluation on HeLa cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5- diphenyltetrazolium bromide) assay. &lt;strong&gt;Results: &lt;/strong&gt;Phytochemical analysis of&lt;em&gt; S. polycystum&lt;/em&gt; extracts are positive for metabolites of flavonoid, steroid, tannin and glycoside. TLC analysis revealed that &lt;em&gt;S. polycystum&lt;/em&gt; extracts containing four phytochemical components. Ethylacetate extract of&lt;em&gt; S. polycystum&lt;/em&gt; showed the highest total phenolic content, and exhibited greater antioxidant activity than ethanol extract. Total phenolic and total flavonoid content in ethylacetate extract are 548.61 μg/mL and 40.06 μg /mL, respectively. Ethylacetate extract of &lt;em&gt;S. polycystum&lt;/em&gt; with IC&lt;sub&gt;50&lt;/sub&gt; value of 298.3 μg/mL is assigned to have a weak antioxidant activity against DPPH free radical. The results indicate that antioxidant activity of ethylacetate extracts of &lt;em&gt;S. polycystum&lt;/em&gt; is directly correlated with its total phenolic and flavonoid content. Moreover, &lt;em&gt;S. polycystum&lt;/em&gt; extracts demonstrated a strong anticancer activity on cervical HeLa cells with IC&lt;sub&gt;50 &lt;/sub&gt;ranging from 38.3 μg/mL to 112.8 μg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; This work confirmed that S.polycystum are promising natural antioxidant and anti-cervical cancer agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">88</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Anton Bahtiar&lt;sup&gt;3&lt;/sup&gt;, Vincent Kharisma Wangsaputra&lt;sup&gt;4&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Wilzar Fachri&lt;sup&gt;5,2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin1, Hiroki Tanimoto&lt;sup&gt;6&lt;/sup&gt;, Kiyomi Kakiuchi&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Pharmacy, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Gerry Kurniawan</style></author><author><style face="normal" font="default" size="100%">Nadzila Anindya Tejaputri</style></author><author><style face="normal" font="default" size="100%">Fona Qorina</style></author><author><style face="normal" font="default" size="100%">Qotrunnada Fithrotunnisa</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Profile, Antioxidant Activity and Cell Line Study of Marine Red Macroalgae Eucheuma cottonii on Lung A-549 Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell line study</style></keyword><keyword><style  face="normal" font="default" size="100%">Eucheuma cottonii</style></keyword><keyword><style  face="normal" font="default" size="100%">Lung A-549 cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">276-281</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;In this century, cancer has increased in incidence and become one of the deadliest disease in the world. However, to date, lung cancer treatments are still not fully effective, quite expensive and very exhaustive for the patient. &lt;em&gt;Eucheuma cottonii&lt;/em&gt; is an abundant marine red macroalgae in Indonesia which have a potential anti-lung cancer properties. Aim of this research is to determine phytochemical profile of &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extracts, as well as to evaluate its antioxidant and cytotoxic effects on Lung A-549 cancer cells.&lt;strong&gt; Methods:&lt;/strong&gt; &lt;em&gt;Eucheuma cottonii&lt;/em&gt; obtained from Sorong beach, West Papua Province, Indonesia, were extracted with three different solvents, that is ethanol, ethylacetate, and n-hexane. These three &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extracts were identified for its phytochemical profiles, antioxidant activity by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, and cytotoxic activity on lung A-549 cells by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Phytochemical analysis revealed that &lt;em&gt;Eucheuma cottonii&lt;/em&gt; contains metabolites of triterpenoid and alkaloid. Antioxidant activity evaluation showed ethanol extract of &lt;em&gt;Eucheuma cottonii &lt;/em&gt;has IC&lt;sub&gt;50&lt;/sub&gt; value of 559.76 μg/mL against DPPH free radical. Whereas cytotoxicity evaluation showed that ethanol extract and ethylacetate extract of &lt;em&gt;Eucheuma cottonii&lt;/em&gt; have cytotoxic effects on Lung A-549 cancer cells, with IC&lt;sub&gt;50 &lt;/sub&gt;value of 251.73 μg/ mL and 261.41 μg/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggesting that &lt;em&gt;Eucheuma cottonii &lt;/em&gt;extract could be further developed as a natural anti-lung cancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">276</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Gerry Kurniawan&lt;sup&gt;3&lt;/sup&gt;, Nadzila Anindya Tejaputri&lt;sup&gt;3&lt;/sup&gt;, Fona Qorina&lt;sup&gt;3&lt;/sup&gt;, Qotrunnada Fithrotunnisa&lt;sup&gt;3&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fitri Santy Budiarso</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Muhammad Hanafi</style></author><author><style face="normal" font="default" size="100%">Roshamur Cahyan Forestrania</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Potential of Stem Bark of Kayu Sarampa (Xylocarpus moluccensis (Lam.) M. Roen)) as α-glucosidase Inhibitor</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase inhibitor</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Kayu Sarampa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1368-1376</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The prevalence of diabetes mellitus type 2 in the world is more than 230 million people, increases about 3% in a year. Kayu Sarampa or Nyirih batu (&lt;em&gt;Xylocarpus moluccensis&lt;/em&gt; (Lam.) M. Roen) has traditionally been used to treat diabetic patient by native people in Ratahan, North Celebes, Indonesia. Therefore, this research was sequentially extracted bioactive component from stem bark of kayu sarampa showed alpha glucosidase inhibitor. &lt;strong&gt;Objective:&lt;/strong&gt; To assess antioxidants and alpha glucosidase inhibitory activity of hexane, ethyl acetate, and methanol extract from stem bark of Kayu Sarampa. &lt;strong&gt;Method:&lt;/strong&gt; The Stem bark was extracted with Reflux method using hexane, ethyl acetate, and methanol as mobile phae/solvent. The Hexane Extract (HE), Ethyl Acetic Extract (EAE) and Methanol Extract (ME) were subjected to the antioxidant activity assay by the 2.2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and the ferric-reducing antioxidant power (FRAP) method. Antidiabetic activity was determined by enzymatic alpha-glucosidase inhibitor. &lt;strong&gt;Results:&lt;/strong&gt; The extract which had the highest activity based on the DPPH test and FRAP test was the ME compared with EAE, and HE with IC50 values of 16.51 μg/mL, 34.10 51 μg/mL, and 38.82 51 μg/mL , respectively. Ferrous equivalent antioxidant capacity (FeEAC) method, methanolic extract had a higher reduction capacity than the EH and EEA which were 148.96 μmol/gr, 48.96 μmol/gr, and 148.96 μmol/gr, respectively. The result showed that kayu sarampa stem bark exhibited antidiabetic activity due to its high inhibition compared with control (acarbose). ME showed inhibition of 53,11% followed with EAE 49,7%, HE 44,53%, and acarbose as control 29,32%.Conclusion: stem bark of kayu sarampa have bioactive component as alpha glucosidase inhibitor&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1368</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Fitri Santy Budiarso&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1,&lt;/sup&gt;*, Muhammad Hanafi&lt;sup&gt;2&lt;/sup&gt;, Roshamur Cahyan Forestrania&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian Institute of Sciences and Faculty of Pharmacy, University of Pancasila, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Maha A Fahmy</style></author><author><style face="normal" font="default" size="100%">Entesar E Hassan</style></author><author><style face="normal" font="default" size="100%">Noha E Ibrahim</style></author><author><style face="normal" font="default" size="100%">Emad M Hassan</style></author><author><style face="normal" font="default" size="100%">Zeinab M Hassan</style></author><author><style face="normal" font="default" size="100%">Enayat A Omara</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Ficus carica Extract Against Hepato-Testicular Side Effects and Genotoxicity Induced by Cisplatin</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bone marrow</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Fig</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver</style></keyword><keyword><style  face="normal" font="default" size="100%">Protection</style></keyword><keyword><style  face="normal" font="default" size="100%">Spermatocytes</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">645-656 </style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present work investigated the protective effect of &lt;em&gt;Ficus carica&lt;/em&gt; (common fig) leaves methanol extract against genotoxicity and testicular damage of cisplatin (CP) and identified some of its active ingredients. &lt;strong&gt;Methods: &lt;/strong&gt;Seven main groups were investigated as follows: I. control negative, II. Control plant (600 mg/kg fig, orally), III, IV. Control positive (treated i.p with 10 and 15 mg/kg CP), V-VII. groups treated with fig (200, 400 and 600 mg/ kg) + Cisplatin (15 mg/kg). &lt;strong&gt;Results:&lt;/strong&gt; &lt;em&gt;Ficus carica&lt;/em&gt; alleviated the destructive effects of CP in the testis, liver and bone marrow due to the presence of high amount of flavonoids and phenolic compounds. Also it has a normal effect in the tested parameters as compared with the control negative. Chromatographic investigation resulted in the identification of 6 compounds: Catechin, Luteolin-8-C-β-D glucopyranoside, Quercetin, Quercetin-3-O-β-d-glucopyranoside, Chlorogenic acid and Kaempferol-3-O-β-D-glucopyranoside. In bone marrow cisplatin induced significant percentage of chromosome abnormalities, micronuclei in polychromatic erythrocytes and toxicity to cells. On the contrary the two tested doses of cisplatin had a normal effect on spermatocyte chromosomes (germ cells). The dose 15 mg/kg induced an overexpression of the liver genes NF-kB and iNOS as indicated by real-time PCR. Different forms of histopathological alterations and instigation of the expression of TNF-α gene in the testis were detected after CP treatment. &lt;strong&gt;Conclusion: &lt;/strong&gt;&lt;em&gt;Ficus carica&lt;/em&gt; is a promising candidate rich in many bioactive constituents and can be used in combination with chemotherapeutic drugs to alleviate their destructive effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">645</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Maha A. Fahmy&lt;sup&gt;1&lt;/sup&gt;, Entesar E. Hassan&lt;sup&gt;1,&lt;/sup&gt;*, Noha E. Ibrahim&lt;sup&gt;2&lt;/sup&gt;, Emad M. Hassan&lt;sup&gt;3&lt;/sup&gt;, Zeinab M. Hassan&lt;sup&gt;4&lt;/sup&gt;, Enayat A. Omara&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Genetics and Cytology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Microbial Biotechnology Department, Genetic Engineering and Biotechnology Division, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medicinal and Aromatic Plants Research Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Natural Compounds Chemistry Department, National Research Centre,Dokki, Cairo, EGYPT&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Pathology Department, National Research Centre, Dokki, Cairo, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sri Ningsih</style></author><author><style face="normal" font="default" size="100%">Fifit Juniarti</style></author><author><style face="normal" font="default" size="100%">Idah Rosidah</style></author><author><style face="normal" font="default" size="100%">Adam Arditya Fajriawan</style></author><author><style face="normal" font="default" size="100%">Kurnia Agustini</style></author><author><style face="normal" font="default" size="100%">Syofi Rosmalawati</style></author><author><style face="normal" font="default" size="100%">Agung Eru Wibowo</style></author><author><style face="normal" font="default" size="100%">Erliana Sasikirana</style></author><author><style face="normal" font="default" size="100%">Wahono Sumaryono</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Study of the Effect of Lampeni (Ardisia humilis Vahl.) Planting Condition toward the Alpha-glucosidase Inhibition Activity in vitro</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alpha-glucosidase</style></keyword><keyword><style  face="normal" font="default" size="100%">Ardisia humilis Vahl.</style></keyword><keyword><style  face="normal" font="default" size="100%">Lampeni</style></keyword><keyword><style  face="normal" font="default" size="100%">Open-air</style></keyword><keyword><style  face="normal" font="default" size="100%">Shedding house</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">377-385</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The quality of a medicinal plant is influenced by agronomic conditions and harvesting time. &lt;strong&gt;Objective: &lt;/strong&gt;This study aimed to evaluate the effect of planting method (openair (OA) and shedding house (SH)) and harvesting time (2, 4, 6 months) of Lampeni (Ardisia humilis Vahl.) toward the inhibitory activity of alpha-glucosidase. &lt;strong&gt;Methods: &lt;/strong&gt;The Lampeni seedling were placed under controlled light conditions (SH) and on direct sun exposure (OA). Harvesting of the leaves was carried out at the age of 2, 4, and 6 months after plantation (2m, 4m, and 6m). Each leaves dry powder was refluxed with methanol 70% and followed by liquid-liquid partition using n-hexane, ethyl acetate (EtOAc), and water. All samples were evaluated toward inhibition of the alpha-glucosidase enzyme &lt;em&gt;in vitro&lt;/em&gt;. Total phenol levels were determined using Folin-Ciocalteu reagent. &lt;strong&gt;Results: &lt;/strong&gt;The results showed that EtOAc fractions of both plantation techniques exhibited the highest inhibition of alpha-glucosidase. The highest activity was demonstrated by the 4m-OA-EtOAc fraction (IC&lt;sub&gt;50&lt;/sub&gt;, 93.50 ppm) and followed by the 6m-OA-EtOAc fraction (IC&lt;sub&gt;50&lt;/sub&gt;, 98.13 ppm). Based on the kinetic study, the inhibition type of the two most active samples were categorized as a non-competitive type. Total phenolic contents were decreased in the following order: 6m-SH-EtOAc &amp;gt; 4m-OA-EtOAc &amp;gt; 6m-OAEtOAc &amp;gt; 4m-SH-EtOAc fraction. It was shown that there was no positive correlation between the strength of inhibition with total phenolic content. &lt;strong&gt;Conclusions:&lt;/strong&gt; This study concluded that Lampeni at open-air plantation harvested on fourth months demonstrated the highest alpha-glucosidase inhibitory activity, although there was no positive correlation between the inhibition activity and phenolic content.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">377</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sri Ningsih&lt;sup&gt;1,&lt;/sup&gt;*, Fifit Juniarti&lt;sup&gt;1&lt;/sup&gt;, Idah Rosidah&lt;sup&gt;1&lt;/sup&gt;, Adam Arditya Fajriawan&lt;sup&gt;1&lt;/sup&gt;, Kurnia Agustini&lt;sup&gt;1&lt;/sup&gt;, Syofi Rosmalawati&lt;sup&gt;2&lt;/sup&gt;, Agung Eru Wibowo&lt;sup&gt;2&lt;/sup&gt;, Erliana Sasikirana&lt;sup&gt;3&lt;/sup&gt;, Wahono Sumaryono&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center for Pharmaceutical and Medical Technology, Agency for the Assessment and Application of Technology. Laptiab building, Puspiptek Serpong Area, South Tangerang, Banten, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Biotechnology, Agency for the Assessment and Application of Technology, Puspiptek Serpong Area, South Tangerang, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Pharmacy, Pancasila University. Srengseng Sawah Street, South Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Vincent Kharisma Wangsaputra</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author><author><style face="normal" font="default" size="100%">Norma Nur Azizah</style></author><author><style face="normal" font="default" size="100%">Lince Dameria Nadapdap</style></author><author><style face="normal" font="default" size="100%">Ajeng Megawati Fajrin</style></author><author><style face="normal" font="default" size="100%">Hiroki Tanimoto</style></author><author><style face="normal" font="default" size="100%">Kiyomi Kakiuchi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis, Characterization, and Cytotoxicity Evaluation of Gallic Acid Nanoparticles Towards Breast T47D Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Gallic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Nanoparticle</style></keyword><keyword><style  face="normal" font="default" size="100%">Synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">T47D cells</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">321-327</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Gallic acid is a naturally polyphenolic acid which shows cytotoxicity against several cancer cells, as well as it displays chemo-preventive activity which is attributed to its strong apoptosis- inducing and antioxidant effects. Thus, gallic acid has become an attractive substance to be further developed due to its strong cytotoxic activity. This study aimed to synthesize gallic acid nanoparticle coating with alginate-chitosan, and evaluate its cytotoxicity against breast T47D cancer cells.&lt;strong&gt; Methods: &lt;/strong&gt;Gallic acid nanoparticle was synthesized using ionic gelation method. The yield, size and morphology of the nanoparticles were determined by UV-Vis Spectroscopy, Transmission electron microscopy (TEM) and Fourier Transform Infrared (FTIR) spectroscopy. Cytotoxicity evaluation of gallic acid nanoparticle towards breast T47D cancer cell is carried out by MTT(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazoliumbromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Spherical nanoparticles of gallic acid with the size of 100-200 nm has been successfully synthesized in 96% of yield. Compared to gallic acid (IC&lt;sub&gt;50&lt;/sub&gt;: 20.86 μg/mL) and alginate-chitosan nanoparticle (IC&lt;sub&gt;50&lt;/sub&gt;: 38.46 μg/mL), gallic acid coating with alginate-chitosan nanoparticles demonstrated higher cytotoxicity towards breast T47D cancer cells with IC&lt;sub&gt;50 &lt;/sub&gt;value of 9.03μg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results clearly confirmed that gallic acid nanoparticles coating with alginate-chitosan showed a strong cytotoxicity towards breast T47D cancer cells, which is potential to be developed as a candidate for new anti-breast cancer agent.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">321</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ade Arsianti&lt;sup&gt;1,2,&lt;/sup&gt;*, Anton Bahtiar&lt;sup&gt;3&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;1,2&lt;/sup&gt;, Vincent Kharisma Wangsaputra&lt;sup&gt;4&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;1&lt;/sup&gt;, Norma Nur Azizah&lt;sup&gt;2&lt;/sup&gt;, Lince Dameria Nadapdap&lt;sup&gt;2&lt;/sup&gt;, Ajeng Megawati Fajrin&lt;sup&gt;1&lt;/sup&gt;, Hiroki Tanimoto&lt;sup&gt;5&lt;/sup&gt;, Kiyomi Kakiuchi&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Chemistry, Faculty of Medicine, University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, University of Indonesia, Jalan Salemba Raya 6 Jakarta 10430, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacology, Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Medical Student, Faculty of Medicine University of Indonesia, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), 8916-5 Takayama-cho, Ikoma, Nara, JAPAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">VV Fedotova</style></author><author><style face="normal" font="default" size="100%">DA Konovalov</style></author><author><style face="normal" font="default" size="100%">АА Kruglaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anatomical Study of Pachyphragma macrophyllum (Hoffm.) N. Busch</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Collenchyma</style></keyword><keyword><style  face="normal" font="default" size="100%">Cross-section</style></keyword><keyword><style  face="normal" font="default" size="100%">Mesophyll</style></keyword><keyword><style  face="normal" font="default" size="100%">Outgrowths on the edge of the leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Pachyphragma macrophyllum</style></keyword><keyword><style  face="normal" font="default" size="100%">Stomata anisocytic type</style></keyword><keyword><style  face="normal" font="default" size="100%">Vascular bundle</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1587-1590</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Pachyphragma macrophyllum &lt;/em&gt;(&lt;em&gt;Hoffm&lt;/em&gt;.) N. Busch is not studied endemic of the Caucasus (Russia) and Turkey. Now in medicine, it is not applied yet, but preliminary data confirm potential use of this plant. For this purpose, it is necessary to carry out the analysis of &lt;em&gt;P. macrophyllum,&lt;/em&gt; and we began with morphological, anatomic studying. &lt;strong&gt;Materials and Methods:&lt;/strong&gt;&lt;em&gt; P. macrophyllum&lt;/em&gt; herb was collected during the flowering period on the Mount Mashuk in Pyatigorsk, Stavropol region, Russia in April 2019. The anatomical structure of &lt;em&gt;P. macrophyllum &lt;/em&gt;is considered in accordance with the requirements of the State Pharmacopoeia XIV. &lt;strong&gt;Results: &lt;/strong&gt;The main morphological signs of &lt;em&gt;P. macrophyllum: &lt;/em&gt;basal leaves have petioles; cordate or reniform. Stem leaves oval, petioles short. The leaves have a serrated margin. The inflorescences grow in a raceme. Fruit cordate silicula. Microscopic signs: on the edge of the leaf blade are outgrowths, walls of cells of the upper and lower epidermis heavily sinuous, stomata as a rule anisocytic type. In cross-section of the leaf, two types of mesophyll: palisade and spongy; vascular bundle collateral round shape. On the cross-section of the stem, the epidermis, collenchyma, parenchyma, collateral vascular bundles are located around. Cells of epidermis of a petal and sepal of a flower polygonal. &lt;strong&gt;Conclusion: &lt;/strong&gt;The received standards will provide reference information for identification, purity, standardisation for the use of &lt;em&gt;P. macrophyllum &lt;/em&gt;as raw materials for medicines.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1587</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;VV Fedotova, DA Konovalov*, АА Kruglaya&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical and Pharmaceutical Institute, a Branch of Volgograd State Medical University Ministry of Health of Russian Federation, Pyatigorsk, 357532, Kalinina 11, RUSSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zulhabri Othman</style></author><author><style face="normal" font="default" size="100%">Hamimi Rasyiqah Hassan Khalep</style></author><author><style face="normal" font="default" size="100%">Azrina Zainal Abidin</style></author><author><style face="normal" font="default" size="100%">Halijah Hassan</style></author><author><style face="normal" font="default" size="100%">Santosh Fattepur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Chicken Chorioallantoic Membrane (CAM) assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia. L leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">White Leghorn eggs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">12-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use &lt;em&gt;Morinda citrifolis.&lt;/em&gt; L extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25%, 50% and 75% of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. &lt;strong&gt;Results:&lt;/strong&gt; Analysis have shown significant differences (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75% extracts showed 37.1% reductions of blood vessel compared to groups 50% and 25% extracts which showed 4% and 12.8% respectively. The phytochemical screening has showed that &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts was positive for flavonoid, phenols and phytosterols. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">12</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Zulhabri Othman&lt;sup&gt;1,2*&lt;/sup&gt;, Hamimi Rasyiqah Hassan Khalep&lt;sup&gt;1&lt;/sup&gt;, Azrina Zainal Abidin&lt;sup&gt;1&lt;/sup&gt;, Halijah Hassan&lt;sup&gt;1&lt;/sup&gt;, Santosh Fattepur&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Graduate Studies, Post-Graduate Centre, Management and Science University, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Marcos Ignacio Jimenez Zuniga</style></author><author><style face="normal" font="default" size="100%">Alejandro Jonathan Hurtado Mariles</style></author><author><style face="normal" font="default" size="100%">Jose Luis Castrejon Flores</style></author><author><style face="normal" font="default" size="100%">Jose Antonio Mondragon Herrera</style></author><author><style face="normal" font="default" size="100%">Maria Guadalupe Ramirez Sotelo</style></author><author><style face="normal" font="default" size="100%">Genaro Ivan Ceron Montes</style></author><author><style face="normal" font="default" size="100%">Yolanda de las Mercedes Gomez y Gomez</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antidepressant-Like Effects of Dracocephalum moldavica L. in Mouse Models of Immobility Tests</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Depression</style></keyword><keyword><style  face="normal" font="default" size="100%">Dracochepalum moldavica L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Forced swim test</style></keyword><keyword><style  face="normal" font="default" size="100%">Tail suspension test</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">976-983</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The aim of this investigation was to evaluate the antidepressant activity of the ethanolic extracts of “toronjil azul”(&lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L.). &lt;strong&gt;Methodology:&lt;/strong&gt; The forced swimming test (FST) and tail suspension test (TST) were performed on CD-1 mice to evaluate the antidepressant activity of the ethanolic extracts. The ethanolic extracts were administered orally at an 80 and 100 mg/kg. The animals were dosed 1, 6 and 24 h before initiating the FST assay and 40 minutes before for the TST assay. Imipramine and fluoxetine were dosed at 15 mg/kg, while the flavonoid quercetin was given an a lower concentration of 10 mg/kg as a positive controls. &lt;strong&gt;Results:&lt;/strong&gt; The extracts of &lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L. and significantly decreased the immobility time in the FST and TST assays when compared with the negative control and reported similar values than those obtained with the positive controls. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results obtained indicate that extract of &lt;em&gt;Dracocephalum moldavica&lt;/em&gt; L. have antidepressant effect similar to those obtained by.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">976</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Marcos Ignacio Jiménez Zúñiga&lt;sup&gt;1&lt;/sup&gt;, Alejandro Jonathan Hurtado Mariles&lt;sup&gt;1&lt;/sup&gt;, José Luis Castrejón Flores&lt;sup&gt;2&lt;/sup&gt;, José Antonio Mondragón Herrera&lt;sup&gt;1,3&lt;/sup&gt;, María Guadalupe Ramírez Sotelo&lt;sup&gt;1&lt;/sup&gt;, Genaro Iván Cerón Montes&lt;sup&gt;4&lt;/sup&gt;, Yolanda de las Mercedes Gómez y Gómez&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratorio de Farmacología, Instituto Politécnico Nacional, Unidad Profesional Interdisciplinaria de Biotecnología, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratorio de Biotecnología Molecular y Cultivo Celular, Av. Acueducto, La Laguna Ticomán, C.P.: 07340, Gustavo A. Madero, Ciudad de México, MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro Médico Nacional Siglo XXI, Hospital de Cardiología, Laboratorio de Patología Molecular, Avenida Cuauhtémoc 330, Doctores, C.P.: 06720, Cuauhtémoc, Ciudad de MEXICO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Universidad Tecnológica de Tecámac, Laboratorio de Bioprocesos, Carretera Federal México-Pachuca, Km. 37.5, Predio Sierra Hermosa, C.P. 55740. Tecámac, Estado de México, MEXICO.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abreu MM</style></author><author><style face="normal" font="default" size="100%">Nobrega P De A</style></author><author><style face="normal" font="default" size="100%">Sales PF</style></author><author><style face="normal" font="default" size="100%">Oliveira FRDe</style></author><author><style face="normal" font="default" size="100%">Nascimento AA</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial and Antidiarrheal Activities of Methanolic Fruit Peel Extract of Pouteria caimito</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Abiu</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiarrheal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Sapotaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">944-950</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;em&gt; &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Pouteria caimito&lt;/em&gt; is a native Amazonian fruit specie, popularly known as &quot;abiu&quot;, that belongs to the Sapotaceae family. It has a wide popular use to relieve diarrhea, cough, fever and inflammation, among other purposes. However, few reports in the scientific literature deal with its phytochemical composition and biological activity. This study aimed to evaluate the antidiarrheal and antimicrobial activity of &lt;em&gt;Pouteria caimito&lt;/em&gt; fruit peel extract. &lt;strong&gt;Methods:&lt;/strong&gt; The antidiarrheal activity was evaluated in mice, using modulation models of normal defecation, cathartic agent-induced diarrhea and stimulated intestinal transit. Antimicrobial activity was, in turn, analyzed against strains of gram-positive and gram-negative bacteria (&lt;em&gt;E. coli, S. epidermidis, S. aureus, Klebsiella pneumonie, E. faecalis and Salmonella tiphy&lt;/em&gt;) through the determination of the minimum inhibitory concentration (MIC) by the microdilution in broth method. Results: This study showed that there was no antidiarrheal activity in the experimental models analyzed and that the methanolic extract of &lt;em&gt;P. caimito&lt;/em&gt; (MEPC) can positively modulate normal defecation. Regarding the antimicrobial activity, the crude extract and the ethyl acetate fraction presented a satisfactory action against most of the strains evaluated except for &lt;em&gt;Enterococcus faecalis&lt;/em&gt; and &lt;em&gt;Salmonella tiphy&lt;/em&gt;. Conclusions: The MEPC did not present any measurable antidiarrheal activity, but more possibly a laxative effect. The extract and acetate fraction showed antimicrobial activity against strains of gram-positive and gram-negative bacteria. The activity of the crude extract was more potent than the results obtained by the use of acetate fractions; the fractions with lower polarity did not present any relevant antimicrobial activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">944</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abreu MM&lt;sup&gt;1,&lt;/sup&gt;*, Nobrega P De A&lt;sup&gt;2&lt;/sup&gt;, Sales PF&lt;sup&gt;2&lt;/sup&gt;, Oliveira FRDe&lt;sup&gt;3&lt;/sup&gt;, Nascimento AA&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Federal University of Amapá, Postgraduate Program in Pharmaceutical Sciences, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Federal University of Amapá, Postgraduate Program in Health Sciences, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Pharmaceutical Sciences, Laboratory of Quality Control, Bromatology and Microbiology, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Camilla Filippi dos Santos Alves</style></author><author><style face="normal" font="default" size="100%">Pauline Cordenonsi Bonez</style></author><author><style face="normal" font="default" size="100%">Marcia de Souza Ebling</style></author><author><style face="normal" font="default" size="100%">Camila Casagrande</style></author><author><style face="normal" font="default" size="100%">Litiane Freitas</style></author><author><style face="normal" font="default" size="100%">Carolina Dolwitsch</style></author><author><style face="normal" font="default" size="100%">Fernanda Pires</style></author><author><style face="normal" font="default" size="100%">Michele Rorato Sagrillo</style></author><author><style face="normal" font="default" size="100%">Gerson Fernandes de Brum</style></author><author><style face="normal" font="default" size="100%">Marli Matiko Anraku de Campos</style></author><author><style face="normal" font="default" size="100%">Roberto Christ Vianna Santos</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antimicrobial, Cyto and Genotoxic Activities of Equisetum hyemale</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Equisetum hyemale</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1563-1571</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The popular use of natural products has great benefits for the health of the human population. In this study we highlight &lt;em&gt;Equisetum hyemale&lt;/em&gt;, belonging to the phylum Sphenophyta and the family Equisetaceae. Popularly, the stems of this plant are used for their diuretic, digestive, anti-anemic, and anti-inflammatory properties. Given this context, and the fact that the growth of antimicrobial resistance is a serious problem for global public health, this plant could be used as an alternative, to increase our therapeutic arsenal. Therefore, it is important to more clearly elucidate the complex structures present in plants, because these substances are mainly responsible for their beneficial and/or toxic effects. Thus, the objective of this study was evaluate the antimicrobial activity, cytotoxic and genotoxic potential of the phenolic compounds separately. The substances luteolin, ferulic acid and coumarin were identified at high concentrations by ultra-high performance chromatography-electrospray ionization-mass spectrometry (UPLC-ESI-MS). Antimicrobial activity was elucidated through microdilution in broth; the phenolic compounds were able to inhibit the visible growth of the standard bacterial strains at low concentrations. Cytotoxicity was evaluated by MTT and genotoxicity was analysed through cellular damage using a Comet assay; the results showed that it did not present cytoxicity or genotoxicity at the corresponding concentrations. With this, we suggest that &lt;em&gt;E. hyemale&lt;/em&gt; may be an alternative for the treatment of infections by microorganisms that are resistant to synthetic drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1563</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Camilla Filippi dos Santos Alves&lt;sup&gt;1,&lt;/sup&gt;*, Pauline Cordenonsi Bonez&lt;sup&gt;2&lt;/sup&gt;, Marcia de Souza Ebling&lt;sup&gt;3&lt;/sup&gt;, Camila Casagrande&lt;sup&gt;2&lt;/sup&gt;, Litiane Freitas&lt;sup&gt;2&lt;/sup&gt;, Carolina Dolwitsch&lt;sup&gt;5&lt;/sup&gt;, Fernanda Pires&lt;sup&gt;5&lt;/sup&gt;, Michele Rorato Sagrillo&lt;sup&gt;4&lt;/sup&gt;, Gerson Fernandes de Brum&lt;sup&gt;4&lt;/sup&gt;, Marli Matiko Anraku de Campos&lt;sup&gt;1&lt;/sup&gt;, Roberto Christ Vianna Santos&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical and Toxicological Analysis, Mycobacteriology Laboratory, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Oral Microbiology Research Laboratory, Microbiology and Parasitology Department, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Graduate Program in Nanoscience, Franciscan University (UFN), Santa Maria, RS, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Cell Culture Laboratory, Universidade Franciscana (UFN), Santa Maria, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Graduate Program in Pharmaceutical Sciences, Universidade Federal de Santa Maria (UFSM), Santa Maria, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raphael de Oliveira Rodrigues</style></author><author><style face="normal" font="default" size="100%">Juliana Navarro Ueda Yaochite</style></author><author><style face="normal" font="default" size="100%">Milena Aguiar Braga</style></author><author><style face="normal" font="default" size="100%">Amanda Ribeiro de</style></author><author><style face="normal" font="default" size="100%">Sousa</style></author><author><style face="normal" font="default" size="100%">Greyce Luri Sasahara</style></author><author><style face="normal" font="default" size="100%">Said Gonçalves da Cruz Fonseca</style></author><author><style face="normal" font="default" size="100%">Thiago Dias de Vasconcelos Araújo</style></author><author><style face="normal" font="default" size="100%">Gilvandete</style></author><author><style face="normal" font="default" size="100%">Maria Pinheiro Santiago</style></author><author><style face="normal" font="default" size="100%">Leôncio Mesquita de Sousa</style></author><author><style face="normal" font="default" size="100%">Jarbas Lima de Carvalho</style></author><author><style face="normal" font="default" size="100%">Francisca Bruna Stefany Aires</style></author><author><style face="normal" font="default" size="100%">do Nascimento</style></author><author><style face="normal" font="default" size="100%">Hélio Vitoriano Nobre Júnior</style></author><author><style face="normal" font="default" size="100%">Aparecida Tiemi Nagao-Dias</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Anti-inflammatory Activities of Bauhinia ungulata L. (Fabaceae) on LPS-Stimulated RAW 264.7 Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Bauhinia ungulata; RAW 264.7 cells; Lipopolysaccharide; Free radicals; Antioxidant activity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">37-42</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of &lt;em&gt;Bauhinia ungulata&lt;/em&gt; L.&lt;strong&gt; Method:&lt;/strong&gt; A flavonoid-rich fraction was obtained from the &lt;em&gt;Bauhinia ungulata&lt;/em&gt; L stem, called the ethyl acetate fraction of &lt;em&gt;Bauhinia ungulata&lt;/em&gt; (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its antioxidant activity on a cell culture model, LPS-stimulated RAW 264.7 cells were treated with different concentrations of FABU and the reactive oxygen species (ROS), nitric oxide (NO), hydrogen peroxide (H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;) and thiobarbituric acid reactive substances (TBARS) production levels were measured. For the analysis of its immunomodulatory capacity, TNF-α, TGF-β and IL-10 levels were determined in the culture supernatant. In order to determinate the antimicrobial activity of FABU, antifungal and antibacterial susceptibility testing was performed against &lt;em&gt;Candida albicans&lt;/em&gt;, methicillinsensitive &lt;em&gt;Staphylococcus aureus,&lt;/em&gt; methicillin-resistant &lt;em&gt;Staphylococcus aureus&lt;/em&gt; and &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; strains. &lt;strong&gt;Result:&lt;/strong&gt; The FABU demonstrated neither significant antimicrobial activity nor immunodulatory capacity; on the other hand, its potential antioxidant activity was demonstrated by the phosphomolibdenium reduction assay. Also, FABU treatment inhibited the ROS, NO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and TBARS levels in the supernatant of LPS-stimulated cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; A significant reduction in the amount of reactive oxygen and nitrogen species (RONS) was observed, in addition to lipid peroxidation inhibition. Our data suggest that the FABU is a natural antioxidant complex that may interfere in the cascade of cell damage caused by free radicals and a promising potential drug in chronic disease models in which immunopathogenicity involves high levels of RONS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">37</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Raphael de Oliveira Rodrigues&lt;sup&gt;1,*&lt;/sup&gt;, Juliana Navarro Ueda Yaochite&lt;sup&gt;1&lt;/sup&gt;, Milena Aguiar Braga&lt;sup&gt;1&lt;/sup&gt;, Amanda Ribeiro de Sousa&lt;sup&gt;1&lt;/sup&gt;, Greyce Luri Sasahara&lt;sup&gt;1&lt;/sup&gt;, Said Gonçalves da Cruz Fonseca&lt;sup&gt;2&lt;/sup&gt;, Thiago Dias de Vasconcelos Araújo&lt;sup&gt;2&lt;/sup&gt;, Gilvandete Maria Pinheiro Santiago&lt;sup&gt;2&lt;/sup&gt;, Leôncio Mesquita de Sousa&lt;sup&gt;3&lt;/sup&gt;, Jarbas Lima de Carvalho&lt;sup&gt;3&lt;/sup&gt;, Francisca Bruna Stefany Aires do Nascimento&lt;sup&gt;1&lt;/sup&gt;, Hélio Vitoriano Nobre Júnior&lt;sup&gt;1&lt;/sup&gt;, Aparecida Tiemi Nagao-Dias&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Clinical Analysis and Toxicology, Faculty of Pharmacy, Universidade Federal do Ceara (UFC), Rua Capitao Francisco Pedro 1210, 60430-370 Fortaleza, CE, BRAZIL.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacy, Universidade Federal do Ceara (UFC), Rua Capitao Francisco Pedro 1210, 60430-370 Fortaleza, CE, BRAZIL.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Organic and Inorganic Chemistry, Sciences Center, Universidade Federal do Ceara (UFC), Campus do Pici 12.200, 60021-940, Fortaleza, CE, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Kainat Ejaz</style></author><author><style face="normal" font="default" size="100%">Mahnoor Wajid</style></author><author><style face="normal" font="default" size="100%">Muzzamil Shehzad</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Azadirachta indica: Antibacterial Activity of Neem Against Different Strains of Bacteria and their Active Constituents as Preventive in Various Diseases</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Azadirachta indica</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural antibiotics</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1597-1604</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Neem has become valuable plant in the world which shows the solutions for hundreds to thousands problems. &lt;em&gt;Azadirachta indica&lt;/em&gt; (Neem) is a rapidly growing evergreen well known tree found Pada generally in various regions of world like America, Africa and India. It has been widely used in Chinese, Ayurveda and Unani medicines across the world especially in Asians countries for the prevention and treatment of diseases. The different parts of neem plant contain biological compounds responsible for antibacterial, antiviral and antifungal activities. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect. Neem tree produces some active compounds which contain biological activities, parts of neem tree such as Root, bark, leaf, flower, seed and fruit together possesses biological activities. Various compounds have been obtained from various parts of neem. Biological activities of few of them have been studied. Hence, the article is aims to utilize the medicinal properties of whole neem plant in various disorders of mankind.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article </style></work-type><section><style face="normal" font="default" size="100%">1597</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Kainat Ejaz&lt;sup&gt;2&lt;/sup&gt;, Mahnoor Wajid&lt;sup&gt;3&lt;/sup&gt;, Muzzamil Shehzad&lt;sup&gt;4&lt;/sup&gt;, Johnny Aldo Tinco- Jayo&lt;sup&gt;5&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;7&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;8&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Sardar Bahadur Khan Women’s University, Balochistan, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biotechnology, University of Central Punjab, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biotechnology, Faisalabad Institute of Research Science and Technology, Faisalabad, PAKISTAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica del Sur, Lima, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Herman Suryadi</style></author><author><style face="normal" font="default" size="100%">Sutriyo</style></author><author><style face="normal" font="default" size="100%">Ghina Fauziah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization Sodium Carboxymethyl Cellulose from Alpha Cellulose Betung Bamboo (Dendrocalamus asper)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkalization</style></keyword><keyword><style  face="normal" font="default" size="100%">Betung bamboo</style></keyword><keyword><style  face="normal" font="default" size="100%">Carboxymethylation</style></keyword><keyword><style  face="normal" font="default" size="100%">Cellulose</style></keyword><keyword><style  face="normal" font="default" size="100%">Characterization</style></keyword><keyword><style  face="normal" font="default" size="100%">Sodium carboxymethylcellulose</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">894-900</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Sodium carboxymethylcellulose (Na-CMC) is one of pharmaceutical excipients that can be used to increase viscosity in topical, oral and parenteral pharmaceutical formulation, beside that it can also be used as binder and disintegrant in tablet formulation. Betung bamboo is one of natural material that contains high concentration of holocellulose for about 83.80%. The purpose of this study was to characterize Na-CMC obtained through alkalization and carboxymethylation reaction. &lt;strong&gt;Methods: &lt;/strong&gt;Alkalization was carried out using 25% sodium hydroxide and 1.7% sodium tetraborate. Carboxymethylation was done with sodium monochloroacetate to alpha cellulose ratio 1.3 : 1. Product was identified by FTIR and further characterized by XRD, SEM, DS value and pH. &lt;strong&gt;Result:&lt;/strong&gt; The product was white colour powder which has similarities of its infrared spectrum to reference. Other characteristics that showed similarities to reference was degree of substitution 0.7073, pH 7.61, average of particle size distribution 71.54 μm, moisture content 5.88%, sulfated ash content 32.64% and loss on drying 9.85%. &lt;strong&gt;Conclusion:&lt;/strong&gt; Based on the comparison of X-ray diffraction, there is similarity between reference and product (Na-CMC) from betung bamboo. However, there were differences in melting temperature, viscosity and morphological analysis with SEM to reference.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">894</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Herman Suryadi*, Sutriyo, Ghina Fauziah&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, Universitas Indonesia, Depok, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rifki Febriansah</style></author><author><style face="normal" font="default" size="100%">Titi Komalasari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Co-Chemotherapeutic Effect of Ageratum conyzoides L. Chloroform Fraction and 5-Fluorouracil on Hela Cell Line</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ageratum conyzoides L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Bcl-XL protein</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular docking</style></keyword><keyword><style  face="normal" font="default" size="100%">Nobiletin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">913-918</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; This study was to determine the co-chemotherapeutic effect of the chloroform fraction of bandotan (&lt;em&gt;Ageratum conyzoides&lt;/em&gt; L.) (CFB) and its combination with 5-Fluorouracil (5-FU) by&lt;em&gt; in vitro&lt;/em&gt; and&lt;em&gt; in silico &lt;/em&gt;assay. &lt;strong&gt;Methods:&lt;/strong&gt; Ethanolic extract of bandotan were fractionated with chloroform. Thin Layer Chromatography (TLC) used to identify active compound and &lt;em&gt;in vitro&lt;/em&gt; study with MTT Assay to determine the viability of HeLa cells after extract treatment.&lt;em&gt; Molecular docking&lt;/em&gt; used Autodock Vina for &lt;em&gt;in silico&lt;/em&gt; study to visualize molecular interaction and affinity between nobiletin and 5-FU with Bcl-XL protein. &lt;strong&gt;Results:&lt;/strong&gt; The result of TLC for CFB showed the Rf value of 0.75, it has the similar value with quersetin standard and indicated that CFB contains flavonoid compound. The &lt;em&gt;Molecular docking&lt;/em&gt; had ΔG for nobiletin and 5-FU were -8.0 and -4.7 kcal/mol, respectively. This result showed that the affinity of nobiletin with Bcl-XL protein higher than 5-FU. Single cytotoxic assay of CFB and 5-FU showed the IC&lt;sub&gt;50&lt;/sub&gt; value of 30 μg/ml and 45 μg/ml, respectively. Combination assay of CFB and 5-FU showed the CI value of 0.36, meaning the presence of synergistic effects. &lt;strong&gt;Conclusion:&lt;/strong&gt; CFB has a positive effect to inhibit viability of HeLa cervical cancer cells and potential to develop as co-chemotherapy agent with 5-FU.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">913</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rifki Febriansah*, Titi Komalasari&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;School of Pharmacy, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Yogyakarta, Yogyakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Rahyussalim</style></author><author><style face="normal" font="default" size="100%">Rizky Priambodo Wisnubaroto</style></author><author><style face="normal" font="default" size="100%">Dilla Firzani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Combination of Spirulina Extract and Sambiloto Effect Histopathologically on Medial Colon from Plasmodium berghei Anka Infected Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Malaria</style></keyword><keyword><style  face="normal" font="default" size="100%">Medial colon</style></keyword><keyword><style  face="normal" font="default" size="100%">Plasmodium berghei Anka</style></keyword><keyword><style  face="normal" font="default" size="100%">Sambiloto</style></keyword><keyword><style  face="normal" font="default" size="100%">Spirulina</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">564-569</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Malaria is one of the biggest burden in medical section in Indonesia, as the prevalence is still high and half of the provinces in Indonesia considered as endemic area.&lt;sup&gt;1-4&lt;/sup&gt; Moreover, the drug resistant case number has grown larger within years.&lt;sup&gt;3-7&lt;/sup&gt; Indonesian people are very close with traditional drug regiment that derived from plants, for example &lt;em&gt;Sambiloto&lt;/em&gt; and &lt;em&gt;Spirulina.&lt;/em&gt;&lt;sup&gt;7-9 &lt;/sup&gt;This research done in order to see the effect of &lt;em&gt;Sambiloto and Spirulina&lt;/em&gt; combination from histopathologic aspect in medial colon of &lt;em&gt;P. berghei &lt;/em&gt;infected mice. &lt;strong&gt;Method:&lt;/strong&gt; The data taken from experimental study using male Swiss Webster mice that has been infected with &lt;em&gt;Plasmodium berghei &lt;/em&gt;Anka. The four groups of mice were given different treatment. The first group treated with &lt;em&gt;Sambiloto &lt;/em&gt;only, the second one with &lt;em&gt;Sambiloto&lt;/em&gt; and Spirulina extract, the third group with &lt;em&gt;Sambiloto and &lt;/em&gt;Spirulina powder and the last one the control group with administration of DHP. &lt;strong&gt;Results:&lt;/strong&gt; The result shows that the group with extract and powder spirulina show a significant result in the inflammatory focus and angiogenesis. However, this research does not necessarily prove the correlation between &lt;em&gt;Sambiloto&lt;/em&gt;-Spirulina and their effect on the goblet cell and dysplasia grade on the infected mice, as the result for both category is insignificant. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study showed that spirulina has positive effect on inflamatory focus and angiogenesis, but the goblet cells count and dysplasia grade result is not noteworthy, as it requires prolonged inflammation process in order to achieve the optimal result.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">564</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Rahyussalim&lt;sup&gt;2&lt;/sup&gt;, Rizky Priambodo Wisnubaroto&lt;sup&gt;2,*&lt;/sup&gt;, Dilla Firzani&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pathological Anatomy, Faculty of Medicine Indonesia, Universitas Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Undergraduate student Faculty of Medicine, Universitas Indonesia, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ali Mohamed El Shamy</style></author><author><style face="normal" font="default" size="100%">Seham Salah El Din El Hawary</style></author><author><style face="normal" font="default" size="100%">Heba Ahmed Fahmy</style></author><author><style face="normal" font="default" size="100%">Shahira Mohammed Ezzat</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative DNA Fingerprinting and Botanical Study of Certain Haworthia and Gasteria Species Growing in Egypt</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Gasteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Haworthia</style></keyword><keyword><style  face="normal" font="default" size="100%">Macromorphology</style></keyword><keyword><style  face="normal" font="default" size="100%">Micromorphology</style></keyword><keyword><style  face="normal" font="default" size="100%">RAPD-PCR</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">388-394</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Haworthia&lt;/em&gt; Duval and &lt;em&gt;Gasteria&lt;/em&gt; Duval are succulent plants, native to South Africa. They have been used worldwide in folk medicine. They are members of the Alooideae subfamily, which has been always viewed as a taxonomically confusing sub-family. The present study aims to differentiate between &lt;em&gt;Haworthia limifolia&lt;/em&gt; Marloth, &lt;em&gt;Gasteria carinata&lt;/em&gt; (Mill.) Duval and &lt;em&gt;Gasteria minima&lt;/em&gt; Poelln. growing in Egypt. &lt;strong&gt;Methods:&lt;/strong&gt; A comparative botanical and genetic investigation is presented. Macromorphological and micromorphological botanical features of the leaves and stems of the species under investigation using the entire specimens, transverse sections and isolated elements. Moreover, their DNA was extracted from the leaf samples and RAPD-PCR analysis was made using 10 primers. &lt;strong&gt;Results:&lt;/strong&gt; The comparative botanical criteria of the examined leaves and stems were identified. Furthermore, the total number of amplified products produced by the ten primers was 98 fragments. Primers OPB-07, OPB-01 and OPB-02, recording high percentage of polymorphism (78.6, 70.6 and 57.1%, respectively), can be used to differentiate between the examined species. While primers OPB-01, OPB-04, OPB-07 and OPB-08, generating fragments with wide molecular size (17, 14, 14 and 11fragments, respectively), can be used for the identification of &lt;em&gt;Haworthia limifolia&lt;/em&gt;, &lt;em&gt;Gasteria carinata&lt;/em&gt; and &lt;em&gt;Gasteria minima&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; The macromorphological, micromorphological and genetic identifying parameters presented in the current study revealed good crieteria to authenticate and differentiate between &lt;em&gt;Haworthia limifolia&lt;/em&gt; Marloth, &lt;em&gt;Gasteria carinat&lt;/em&gt;a (Mill.) Duval and &lt;em&gt;Gasteria minima&lt;/em&gt; Poelln.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">388</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Ali Mohamed El Shamy&lt;sup&gt;1&lt;/sup&gt;, Seham Salah El Din El Hawary&lt;sup&gt;1&lt;/sup&gt;, Heba Ahmed Fahmy&lt;sup&gt;2,&lt;/sup&gt;*, Shahira Mohammed Ezzat&lt;sup&gt;1,3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Einy Street, 11562, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, EGYPT.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), 6th October, 12566, EGYPT.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vanessa de Andrade Royo</style></author><author><style face="normal" font="default" size="100%">Juliana Almeida Rocha</style></author><author><style face="normal" font="default" size="100%">Kamylla Teixeira Santos</style></author><author><style face="normal" font="default" size="100%">Jeane Ferreira Leal Freitas</style></author><author><style face="normal" font="default" size="100%">Clarice Avelar Almeida</style></author><author><style face="normal" font="default" size="100%">Bianca Ribeiro</style></author><author><style face="normal" font="default" size="100%">Elytania Veiga Menezes</style></author><author><style face="normal" font="default" size="100%">Dario Alves de Oliveira</style></author><author><style face="normal" font="default" size="100%">Murilo Malveira Brandão</style></author><author><style face="normal" font="default" size="100%">Afranio Farias de Melo Júnior</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Studies Between Mauritia flexuosa and Mauritiella armata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Arecaceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Secondary metabolites</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">32-36</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;em&gt;Mauritia flexuosa&lt;/em&gt; and &lt;em&gt;Mauritiella armata&lt;/em&gt; belong to the family Arecaceae and are widely found in Brazil. &lt;strong&gt;Aim:&lt;/strong&gt; In this work were evaluated: the phytochemical profile of the secretion popularly known as &lt;em&gt;M. flexuosa&lt;/em&gt; wine, antioxidant activity of leaf, root and petiole hydroethanolic extracts of the two species, as well as the quantification of flavonoids and the chromatographic profile by means of high performance liquid chromatography. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The chromatographic profile was determined by high performance liquid chromatography, quantification of flavonoids and antioxidant activity, were performed by spectrophotometric method. &lt;strong&gt;Results:&lt;/strong&gt; Antioxidant activity and presence of flavonoids were observed in the extracts of all the analyzed structures of the two species. The phytochemical profile of the wine evidenced the presence of secondary metabolites reported in other structures of &lt;em&gt;M. flexuosa&lt;/em&gt;. In the chromatographic analysis, it was observed that the extracts evaluated have between three and nine compounds.&lt;strong&gt; Conclusion:&lt;/strong&gt; Further studies should be performed to identify the active compounds in the two species.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Vanessa de Andrade Royo&lt;sup&gt;1,*&lt;/sup&gt;, Juliana Almeida Rocha&lt;sup&gt;1&lt;/sup&gt;, Kamylla Teixeira Santos&lt;sup&gt;1&lt;/sup&gt;, Jeane Ferreira Leal Freitas&lt;sup&gt;1&lt;/sup&gt;, Clarice Avelar Almeida&lt;sup&gt;1&lt;/sup&gt;, Bianca Ribeiro&lt;sup&gt;1&lt;/sup&gt;, Elytania Veiga Menezes&lt;sup&gt;2&lt;/sup&gt;, Dario Alves de Oliveira&lt;sup&gt;2&lt;/sup&gt;, Murilo Malveira Brandão&lt;sup&gt;2&lt;/sup&gt;, Afranio Farias de Melo Júnior&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Natural Products, State University of Montes Claros, Avenida Dr. Ruy Braga, S/N - Vila Mauriceia, 39401-089, Montes Claros - MG, BRAZIL.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Bioporpection and Genetic Resources, State University of Montes Claros, Avenida Dr. Ruy Braga, S/N - Vila Mauriceia, 39401-089, Montes Claros - MG, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Atanu FO</style></author><author><style face="normal" font="default" size="100%">Avwioroko OJ</style></author><author><style face="normal" font="default" size="100%">Ilesanmi OB</style></author><author><style face="normal" font="default" size="100%">Oguche M</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Study of the Effects of Annona muricata and Tapinanthus globiferus Extracts on Biochemical Indices of Diabetic Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alloxan</style></keyword><keyword><style  face="normal" font="default" size="100%">Annona muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">Diabetes</style></keyword><keyword><style  face="normal" font="default" size="100%">Mistletoe</style></keyword><keyword><style  face="normal" font="default" size="100%">Tapinanthus globiferus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1365-1370</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Annona muricata&lt;/em&gt; and &lt;em&gt;Tapinanthus globiferus&lt;/em&gt; (mistletoe) are medicinal plants used in traditional medicine to combat an array of human diseases. However, there is dearth of scientific prove for the activity of these plants in the management of non-infectious human diseases such as cancer, insomnia, hypertension, ulcers and diabetes. &lt;strong&gt;Method:&lt;/strong&gt; The present study was designed to assess comparatively the effects of methanol extracts of &lt;em&gt;Annona muricata&lt;/em&gt; (AME) and &lt;em&gt;Tapinanthus globiferus&lt;/em&gt; (TGE) on biochemical indices of alloxan induced diabetic rats. The animals were allocated to eight (8) groups, group I were normal non-diabetic rats, group II (diabetic untreated group), group III treated with metformin alone, groups IV &amp;amp; V were diabetic rats treated with AME at dose of concentration 200 mg/kg BW &amp;amp; 400 mg/kg BW respectively, groups VI &amp;amp; VII were diabetic rats treated with 200 mg/kg BW &amp;amp; 400 mg/kg BW of TGE respectively. Group VIII were diabetic rats treated with AME + TGE at concentration of 200 mg/kg BW each. Concentrations of serum total cholesterol (TC), high density lipoprotein (HDL), triglyceride (TG) of alloxan diabetic rats, creatinine and urea were assayed after 21 days of the respective treatments. &lt;strong&gt;Results:&lt;/strong&gt; Diabetic untreated rats had significant increase &lt;em&gt;p&lt;/em&gt;&amp;lt;0.05 in TC, TG, urea and creatinine compared to normal control group as opposed to the significant decrease observed for HDL in diabetic rats. However, treatment of diabetic rats with AME and TGE significantly suppressed (&lt;em&gt;p&lt;/em&gt;&amp;lt;0.05) the concentrations of TC, TG and creatinine when compared with the diabetic untreated rats. A similar trend was observed for the calculated atherogenic index of treated rats when compared with diabetic untreated rats. Interestingly, co-administration of AME + TGE improved the biochemical indices of diabetic rats better than using each plant separately. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of this study suggest that AME and TGE could offer some benefits in the management of diabetic complications especially with regard to cardiac and renal health.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1365</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Atanu FO&lt;sup&gt;1&lt;/sup&gt;,*, Avwioroko OJ&lt;sup&gt;2&lt;/sup&gt;, Ilesanmi OB&lt;sup&gt;3&lt;/sup&gt;, Oguche M&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Natural Sciences, Kogi State University, Anyigba, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical Sciences, College of Natural Sciences, Redeemer’s University, Ede, Osun State, NIGERIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Biological Sciences, Faculty of Science, Federal University Otuoke, Bayelsa State, NIGERIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hesti Riasari</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Rika Hartati</style></author><author><style face="normal" font="default" size="100%">Kusnandar Anggadiredja</style></author><author><style face="normal" font="default" size="100%">Sukrasno</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Extraction Methods, Antioxidant Activities, Total Phenol in Seeds and Seed Shells of Kabau (Archidendron bubalinum (Jack) I.C. Nielsen) From Lampung and South Sumatra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Archidendron bubalinum (Jack) Nielsen</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Seed shell</style></keyword><keyword><style  face="normal" font="default" size="100%">Seeds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1278-1284</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Kabau is one of the famous plants in Lampung and South Sumatra. Kabau is usually used as an ingredient to increase the aroma of cooking. Kabau is a plant belongs to the same genus with &lt;em&gt;Archidendron pauciflorium&lt;/em&gt; (Benth.) IC. Nielsen and in the same family with &lt;em&gt;Leucaena leucocephala &lt;/em&gt;L. &lt;strong&gt;Objective: &lt;/strong&gt;The purpose of this research was to compare the total phenolic content and the antioxidant activity between seed and fruit carp (shell) of kabau grown in Lampung and South Sumatra. &lt;strong&gt;Method: &lt;/strong&gt;Kabau seeds and the shells were obtained from Lampung and South Sumatra. Extractions were conducted by maceration and a continuous extraction using Soxhlet apparatus with ethanol as the solvent. Phenolic content and the antioxidant activity of the extract were then measured. &lt;strong&gt;Results:&lt;/strong&gt; The antioxidant activity and high phenol levels were found in kabau shell extract obtained by maceration method with IC-50 value of seed shell from Lampung 17.61 μg/mL and 44, 7 μg / mL for those from South Sumatra. Phenol content of seed shell from Lampung 11.74 g GAE / 100 g and South Sumatra 5.88 g GAE / 100 g&lt;strong&gt;. Conclusion: &lt;/strong&gt;Based on the research that has been done, it can be concluded that high antioxidant activity and high levels of total phenol were found in shell extract obtained by maceration of shell from Lampung and South Sumatra.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1278</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Hesti Riasari&lt;sup&gt;1,2&lt;/sup&gt;,*, Sani Nurlaela Fitriansyah&lt;sup&gt;2&lt;/sup&gt;, Rika Hartati&lt;sup&gt;1&lt;/sup&gt;, Kusnandar Anggadiredja&lt;sup&gt;1&lt;/sup&gt;, Sukrasno&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, School of Pharmacy, Institut Teknologi Bandung, Jl Ganesha 10, Bandung 40132, West Java, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Indonesian School of Pharmacy. Jl. Soekarno Hatta 354, Bandung 40266 West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez-Asmat</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Luz Chacaltana-Ramos</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Sacha Inchi Oil (Plukenetia volubilis L.) on Genotoxicity in Mice (Mus musculus) and Subchronic Toxicity in Goldfish (Carassius auratus)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Genotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha Inchi Oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Subchronic Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1549-1557</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt; Plukenetia volubilis&lt;/em&gt; is known as Sacha Inchi (SI) is originary from the peruvian amazone and it has been cultivated and consumed since the pre and Inca's time. &lt;strong&gt;Objective: &lt;/strong&gt;Sacha inchi oil was assessed for genotoxicity in Balb C albino mice and subchronic toxicity in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;). &lt;strong&gt;Material and Methods:&lt;/strong&gt; The genotoxicity was assessed in Mus musculus Balb C (&lt;em&gt;n&lt;/em&gt; = 25) separated into five groups randomly selected of twenty-five each one. Groups were 10 mL / kg normal saline (NS), 40 mg / kg cyclophosphamide group (CP) and the three other groups received cyclophosphamide and sacha inchi oil of concentrations 10, 100 and 1000 mg / kg respectively. The substances were administered three times during 24 hours. The genotoxicity in mice was evaluated determining micronucleus levels in blood and bone marrow. The subchronic toxicity was assessed in goldfish (&lt;em&gt;Carassius auratus&lt;/em&gt;) (&lt;em&gt;n &lt;/em&gt;= 48) separated into four groups randomly selected of six each: normal saline group (control) and three groups that received doses of 10, 100 and 1000 μg sacha inchi oil per litre of water respectively for 45 days. &lt;strong&gt;Results:&lt;/strong&gt; The values of weight, length, growth rate, condition factor (K) and number of survivors were recorded. CP group showed higher micronuclei levels in blood and bone marrow compared with sacha inchi oil 10, 100 and 1000 mg / kg groups (ANOVA Test &lt;em&gt;p&lt;/em&gt; &amp;lt;0.01 Scheffe´s Post Hoc &lt;em&gt;p &lt;/em&gt;&amp;lt;0.05, &lt;em&gt;p &lt;/em&gt;&amp;lt;0.01 and &lt;em&gt;p&lt;/em&gt; &amp;lt;0.001 respectively). The subchronic toxicity assessment in goldfish showed isometric growth, a decline in &quot;K&quot; and a similar specific percentage growth rate per day in all groups (ANOVA test &lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;Sacha inchi oil was not toxic under experimental conditions.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1549</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,&lt;/sup&gt;*, Jorge Luis Arroyo-Acevedo&lt;sup&gt;2&lt;/sup&gt;, Roberto Chávez-Asmat&lt;sup&gt;3&lt;/sup&gt;, Juan Pedro Rojas-Armas&lt;sup&gt;2&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz Cerrate&lt;sup&gt;5&lt;/sup&gt;, Cesar Franco-Quino&lt;sup&gt;6&lt;/sup&gt;, Luz Chacaltana-Ramos&lt;sup&gt;7&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;8 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima 15001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho 05001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Cientifica del Sur, Lima 15001, PERU&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15001, Peru.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica 11001, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;8&lt;/sup&gt;Universidad Continental, Huancayo 12002, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Irani Binti Alloha</style></author><author><style face="normal" font="default" size="100%">Nurul ‘Ain Liyana Binti Aziz</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author><author><style face="normal" font="default" size="100%">Zurainie Abllah</style></author><author><style face="normal" font="default" size="100%">Mohd Hafiz Arzmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Eurycoma Longifolia Jack (Tongkat Ali) Alcoholic Root Extract Against Oral Pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antifungal</style></keyword><keyword><style  face="normal" font="default" size="100%">Candida albicans</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactobacillus casei.</style></keyword><keyword><style  face="normal" font="default" size="100%">Root extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus mutans</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1299-1302</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Eurycoma longifolia jack (E.L) is a herbal medicinal plant of South-East Asian origin, popularly recognized as ‘Tongkat Ali.’ The plant roots have been scientifically proven to have many biological effects including antibacterial activity however, no previous research to date has studied the effect on oral pathogens including cariogenic bacteria. This study was done to determine the antibacterial and antifungal activities of E.L. root extract against three common oral pathogens. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The microorganisms used were &lt;em&gt;Candida albicans, Streptococcus mutans &lt;/em&gt;and &lt;em&gt;Lactobacillus casei.&lt;/em&gt; E.L root was extracted using soxhlet method. Disc diffusion assay was conducted using extract concentration of 200 mg/ml. Nystatin and Ampicillin were used as positive control for fungal and bacterial tests respectively. Minimum Inhibitory Concentration (MIC) was done to determine the lowest inhibitory concentration of the extract on the microorganisms. &lt;strong&gt;Results: &lt;/strong&gt;E.L extract inhibited the growth of Candida albicans and Streptococcus mutans at a concentration of 200 mg/ ml with a zone of inhibition of 16.0 ± 3.0 mm and 7.0 ± 1.0 mm respectively. There was no antimicrobial effect of the extract on Lactobacillus casei. The MIC of E.L extract against both Candida albicans and Streptococcus mutans was 25 mg/ml. &lt;strong&gt;Conclusions: &lt;/strong&gt;The results from this study revealed the potential use of Eurycoma longifolia jack as an antimicrobial agent which can be used to produce new oral care products.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1299</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Irani Binti Alloha&lt;sup&gt;1&lt;/sup&gt;, Nurul ‘Ain Liyana Binti Aziz&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2&lt;/sup&gt;,*, Zurainie Abllah&lt;sup&gt;3&lt;/sup&gt;, Mohd Hafiz Arzmi&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Students, Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Lecturer, Fundamental Dental and Medical Sciences Department Kuliyyah of Dentistry, IIUM, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Paediatric Dentistry and dental public health, IIUM, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Cutt Fazzlieanie Bactiar</style></author><author><style face="normal" font="default" size="100%">Nur Azlina Mohd Fahami</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">LC-MS Analysis of Phytocomponents in the Methanol Extract of Piper Sarmentosum Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavanoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Lignan</style></keyword><keyword><style  face="normal" font="default" size="100%">Liquid-chromatography mass-spectrometry (LC-MS) analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Naringine</style></keyword><keyword><style  face="normal" font="default" size="100%">Piper sarmentosum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1071-1076</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Piper sarmentosum&lt;/em&gt; is a cultivated plant that grows wildly in the tropical and subtropical region including in Malaysia. It has a wide usage in traditional medicine and have a variety of active chemical constituents. &lt;strong&gt;Aim: &lt;/strong&gt;The aim of this study is to isolate and identify the active compounds from the methanol extracts of leaves of &lt;em&gt;P. sarmentosum&lt;/em&gt;. &lt;strong&gt;Methods and Materials:&lt;/strong&gt; The fresh leaves of &lt;em&gt;Piper sarmentosum&lt;/em&gt; were collected from the Ethnobotanic garden of Forest Research Institute Malaysia (FRIM) after being identified and confirmed by a plant taxonomist from Medicinal Plant Divison (Voucher specimen code no: FRI 45870). The methanolic extraction procedure were performed at FRIM labrotory. The extract was then sent to Research and Instrumentation Management Centre (CRIM) UKM for Liquid Chromatography Mass Spectrometry (LCMS) analysis. &lt;em&gt;Results: &lt;/em&gt;Fifteen compounds were isolated from the fresh leaves of &lt;em&gt;Piper sarmentosum&lt;/em&gt;. Six of these have been previously isolated from the roots and essential oil of this plant:&lt;strong&gt; (2)&lt;/strong&gt; Naringenin, &lt;strong&gt;(3)&lt;/strong&gt; Methyl piperate, &lt;strong&gt;(5)&lt;/strong&gt; Beta-Asarone, &lt;strong&gt;(6)&lt;/strong&gt; Brachyamide B, &lt;strong&gt;(8) &lt;/strong&gt;Piperitol and&lt;strong&gt; (9)(10)&lt;/strong&gt; Guineensine. &lt;strong&gt;(1)(12)&lt;/strong&gt; Didymin, &lt;strong&gt;(4) &lt;/strong&gt;Quercetin,&lt;strong&gt; (7) &lt;/strong&gt;Amurensin &lt;strong&gt;(11)&lt;/strong&gt; Hesperidin, and &lt;strong&gt;(15) &lt;/strong&gt;Difucol are new for&lt;em&gt; P. sarmentosum&lt;/em&gt; (Piperaceae). &lt;strong&gt;Conclusion:&lt;/strong&gt; From the result, it is evident that &lt;em&gt;Piper sarmentosum&lt;/em&gt; contains various bioactive compounds.&lt;strong&gt; (1)(12)&lt;/strong&gt; Didymin, &lt;strong&gt;(4) &lt;/strong&gt;Quercetin, &lt;strong&gt;(7)&lt;/strong&gt; Amurensin,&lt;strong&gt; (11)&lt;/strong&gt; Hesperidin, and &lt;strong&gt;(15)&lt;/strong&gt; Difucol are new natural compounds that have not been reported before.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1071</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Cutt Fazzlieanie Bactiar, Nur Azlina Mohd Fahami*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Faculty of Medicine, UKMMC, Universiti Kebangsaan Malaysia, Kuala Lumpur, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carlos A.S. Souza</style></author><author><style face="normal" font="default" size="100%">Wesley M.G. Andrade</style></author><author><style face="normal" font="default" size="100%">Thaís S. Ramos</style></author><author><style face="normal" font="default" size="100%">Alex J. S. Filho</style></author><author><style face="normal" font="default" size="100%">Anderson L. Freitas</style></author><author><style face="normal" font="default" size="100%">Tamires C. Lima</style></author><author><style face="normal" font="default" size="100%">Ângelo R. Antoniolli</style></author><author><style face="normal" font="default" size="100%">Wellington B. Silva</style></author><author><style face="normal" font="default" size="100%">Francilene A. Silva</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Medicinal Plants in Basic Care: A Study of Clinical Practice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brazilian Unified Health System</style></keyword><keyword><style  face="normal" font="default" size="100%">Healthcare Unit</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional and Complementary Medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">796-802</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;According to World Health Organization, 80% of world population uses traditional practices for primary health care, and 85% of this shares the use of medicinal plants or plants-based preparations. Thus, the present work had as objective to investigate the profile of herbal medicine use as well as the conditions to the alive pharmacy implementation in four basic health units in the city of Aracaju, Sergipe, Brazil. For such, 84 family health professionals were interviewed about the use of medicinal plants. Concerning the indication of medicinal plants, 41.67% of the health staff prescribes medicinal plants, 55.95% reported never having prescribed medicinal plants and 2.4% abstained from responding. Despite the intention to use phytotherapy as a therapeutic practice, this practice is not yet fully inserted in the analyzed units due to factors such as lack of training and specific protocols to assist professionals in the use of medicinal plants and phytotherapics.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">796</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carlos A.S. Souza&lt;sup&gt;1,*&lt;/sup&gt;, Wesley M.G. Andrade&lt;sup&gt;1&lt;/sup&gt;, Thaís S. Ramos&lt;sup&gt;1&lt;/sup&gt;, Alex J. S. Filho&lt;sup&gt;2&lt;/sup&gt;, Anderson L. Freitas&lt;sup&gt;1&lt;/sup&gt;, Tamires C. Lima&lt;sup&gt;1&lt;/sup&gt;, Ângelo R. Antoniolli&lt;sup&gt;3&lt;/sup&gt;, Wellington B. Silva&lt;sup&gt;1&lt;/sup&gt;, Francilene A. Silva&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmácia, Universidade Federal de Sergipe, Av. Marechal Rondon, s/n, Cidade Universitária, São Cristóvão, Sergipe 49100-000, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Biologia, Universidade Federal de Sergipe, Av. Marechal Rondon, s/n, Cidade Universitária, São Cristóvão, Sergipe 49100-000, BRAZIL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Fisiologia, Universidade Federal de Sergipe, Av. Marechal Rondon, s/n, Cidade Universitária, São Cristóvão, Sergipe 49100-000, BRAZIL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Ricardo Ángel Yuli-Posadas</style></author><author><style face="normal" font="default" size="100%">Johnny Aldo Tinco-Jayo</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">Linder Figueroa-Salvador</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effect of Sacha Inchi Oil (Plukenetia volubilis L.) in an Experimental Model of Epilepsy</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Convulsion</style></keyword><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Omega</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentylenetetrazole</style></keyword><keyword><style  face="normal" font="default" size="100%">Plukenetia Volubilis</style></keyword><keyword><style  face="normal" font="default" size="100%">Sacha inchi</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1591-1596</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Experimental studies have demonstrated that fatty acids such as omega 3 and 6 have anti-inflammatory, anticonvulsant, cardio protective and anti-tumor effects. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to determine the protective effect of sacha inchi oil on pentylenetetrazoleinduced seizures in albino mice. &lt;strong&gt;Material and Methods: &lt;/strong&gt;Thirty male Balb/C albino mice of 8 weeks of age were purchased from the National Institute of Health (Lima-Peru). The animals were divided into 5 groups of 6 animals each one. Group I: Control; PTZ (pentylenetetrazole 80 mg / kg, s.c.). II: PTZ + Diazepam (1 mg / kg; s.c.). Group III, IV, V: PTZ + sacha inchi oil at single doses of 250, 500, 1000 mg / kg respectively orally. Sacha inchi oil was administered 30 minutes before induction of seizures by PTZ. Next, various parameters such as latency, seizure frequency, duration and score were scored according to Racine scale. The program Graph Pad Prism v.4 was used for statistical analysis. &lt;strong&gt;Results: &lt;/strong&gt;As result, the experimental group treated with sacha inchi oil at maximum dose of 1000 mg/kg showed better results in response to PTZ induced seizure; low levels of seizures, frequency and duration (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.001; ANOVA, &lt;em&gt;P&lt;/em&gt; &amp;lt;0.001 Post-hoc Dunnett test). &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that Sacha inchi oil presented anticonvulsant effect at the highest doses tested being very similar to Diazepam. The main mechanism could be by reducing free radical and improving GABA levels in the brain.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1591</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Oscar Herrera-Calderon&lt;sup&gt;1,*&lt;/sup&gt;, Ricardo Ángel Yuli-Posadas&lt;sup&gt;2&lt;/sup&gt;, Johnny Aldo Tinco-Jayo&lt;sup&gt;3&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;3&lt;/sup&gt;, César Franco- Quino&lt;sup&gt;4&lt;/sup&gt;, Victor Chumpitaz- Cerrate&lt;sup&gt;5&lt;/sup&gt;, Linder Figueroa- Salvador&lt;sup&gt;6 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Universidad Continental, Huancayo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laboratory of Pharmacology, Universidad Científica Del Sur, Lima, PERU. 6School of Medicine, Universidad Peruana de Ciencias Aplicadas, Lima PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;School of Medicine, Universidad Peruana de&amp;nbsp;Ciencias Aplicadas, Lima PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dennis RA Mans</style></author><author><style face="normal" font="default" size="100%">Meryll Djotaroeno</style></author><author><style face="normal" font="default" size="100%">Priscilla Friperson</style></author><author><style face="normal" font="default" size="100%">Jennifer Pawirodihardjo</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Pharmacological Support for the Traditional Uses of Zingiberacea Species in Suriname - A Review of the Literature</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Pharmacological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Rationale</style></keyword><keyword><style  face="normal" font="default" size="100%">Suriname</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional uses</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiberaceae</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1511-1525</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The &lt;em&gt;Zingiberacea&lt;/em&gt; or ginger family is a family of flowering plants comprising roughly 1,600 species of aromatic perennial herbs with creeping horizontal or tuberous rhizomes divided into about 50 genera. The &lt;em&gt;Zingiberaceae &lt;/em&gt;are distributed throughout tropical Africa, Asia, and the Americas. Many members are economically important as spices, ornamentals, cosmetics, traditional medicines, and/or ingredients of religious rituals. One of the most prominent characteristics of this plant family is the presence of essential oils in particularly the rhizomes but in some cases also the leaves and other parts of the plant. The essential oils are in general made up of a variety of, among others, terpenoid and phenolic compounds with important biological activities. The Republic of Suriname (South America) is well-known for its ethnic and cultural diversity as well as its extensive ethnopharmacological knowledge and unique plant biodiversity. This paper first presents some general information on the &lt;em&gt;Zingiberacea &lt;/em&gt;family, subsequently provides some background about Suriname and the &lt;em&gt;Zingiberacea&lt;/em&gt; species in the country, then extensively addresses the traditional uses of one representative of the seven genera in the country and provides the phytochemical and pharmacological support for these uses, and concludes with a critical appraisal of the medicinal values of these plants.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1511</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dennis RA Mans*, Meryll Djotaroeno, Priscilla Friperson, Jennifer Pawirodihardjo&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacology, Faculty of Medical Sciences, Anton de Kom University of Suriname, Paramaribo, SURINAME.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Galuh Widiyarti</style></author><author><style face="normal" font="default" size="100%">Winda Fitrianingsih</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Constituents and Free Radical Scavenging Activity of Madang Gatal (Schima wallichii) Choisy Stem Bark</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">13-hydroxy methyl ester</style></keyword><keyword><style  face="normal" font="default" size="100%">14-methyl-</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chromatography</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Pentadecanoic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Schima wallichii stem bark</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">395-399</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Madang gatal (&lt;em&gt;Schima wallichii&lt;/em&gt;) Choisy is one of typical Indonesian plants that used traditionally as insomnia and hypertension drug. &lt;strong&gt;Background:&lt;/strong&gt; The environment is highly polluted by free radicals which may contribute to the aging process of tissue and cause chronic diseases. The aims of the research were to study the phytochemical constituents and free radical scavenging activity of &lt;em&gt;Schima wallichii&lt;/em&gt; stem bark. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Extraction of &lt;em&gt;S.wallichii&lt;/em&gt; stem bark was carried out by maceration method using methanol and then the methanol extract was partitioned using n-hexane, ethyl acetate and butanol successively. The methanol extract was then screened to determine the presence of different classes of secondary metabolites. The ethyl acetate fraction was subjected to silica column chromatography followed by exclusion chromatography on sephadex LH-20 to yield two partially purified isolates, SA and SE4. FTIR and GC-MS analyses indicated SA asa mixture of&lt;em&gt; pentadecanoic acid&lt;/em&gt;, &lt;em&gt;14-methyl-, methyl esterand&lt;/em&gt; patchouli alcohol, while SE4 was made up predominantly of &lt;em&gt;pentadecanoic acid, 14-methyl-, 13-hydroxy methyl ester&lt;/em&gt;. Free radical scavenging activity was performed by using2,2-diphenyl-1-picrylhydrazyl (DPPH) radical oxidation method. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening indicated the presence of alkaloids, flavonoids, tannins, saponins, terpenes and quinones. All tested samples, methanol, n-hexane, ethyl acetate and butanol extracts showed strong antioxidant activity with IC50 values of 8.58, 17.36, 8.17 and 8.79 μg/mL, respectively. The isolates showed strong antioxidant activity with SE4 exhibiting an IC50 value of about 5.5 times stronger than quercetin used as a standard antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">395</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;!-- x-tinymce/html --&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;Galuh Widiyarti&lt;sup&gt;1,&lt;/sup&gt;* Winda Fitrianingsih&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Research Center for Chemistry, Indonesian Institute of Sciences (LIPI), Kawasan PUSPIPTEK Serpong, Tangerang Selatan, Banten 15314, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Mathematics and Natural Science Faculty, University of Jendral Soedirman, Purwokerto, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abed S. Ahmed</style></author><author><style face="normal" font="default" size="100%">Abo Khthr M. Fanokh</style></author><author><style face="normal" font="default" size="100%">Mahood A. Mahdi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Identification and Anti-Oxidant Study of Essential Oil Constituents of Ocimum basilicum L. Growing in Iraq</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">Linalool</style></keyword><keyword><style  face="normal" font="default" size="100%">O. basilicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai basil</style></keyword><keyword><style  face="normal" font="default" size="100%">β-carotene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">724-729</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Essential oil of Iraqi growing &lt;em&gt;Ocimum basilicum&lt;/em&gt; (Thia basil) was studied for their chemical components investigation and antioxidant activity. &lt;strong&gt;Methods:&lt;/strong&gt; Essential oils of leaves and stems of&lt;em&gt; Ocimum basilicum&lt;/em&gt; were collected using hydrodistillation by Clevenger apparatus. Components of the collected essential oils were examined by the techniques such as Gas chromatography and Gas chromatography–mass spectrometry. &lt;strong&gt;Results: &lt;/strong&gt;The analysis showed that the major components of essential oils were linalool (48.69%), 1,8-cineole (14.00%), trans-α-bergamotene (8.23%) and eugenol (6.64%). The antioxidant investigation was achieved using 1,1-diphenyl-2-picrylhydrazyl (DPPH) as a radical scavenger and bleaching of β-carotene/linoleic assay. The essential oil displayed strong inhibition with 110.8% against autoxidation of linoleic acid, while the scavenging of DPPH radical gave a value of IC&lt;sub&gt;50 &lt;/sub&gt;145.35 μg/mL. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results signify that essential oils of &lt;em&gt;O. Basilicum&lt;/em&gt; could be used for pharmaceutical studies and preservative in the food industry. This is the first study of the essential components of new cultivate of Thai basil in Iraq.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">724</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Abed S. Ahmed&lt;sup&gt;1,*&lt;/sup&gt;, Abo Khthr M. Fanokh&lt;sup&gt;2&lt;/sup&gt;, Mahood A. Mahdi&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Products of Pharmacognosy Department, Pharmacy College, University of Kerbala, Kerbala, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Master in Pharmaceutical Chemistry Department, Pharmacy College, University of Kerbala, Kerbala, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Full Professor Pharmaceutical Chemistry Department, Pharmacy College, University of Kerbala, Kerbala, IRAQ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alioune Dior FALL</style></author><author><style face="normal" font="default" size="100%">Serigne Ibra Mbacké DIENG</style></author><author><style face="normal" font="default" size="100%">Abdou SARR</style></author><author><style face="normal" font="default" size="100%">Mbaye DIENG</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Antioxidant Effect of Ethanol Leaf and Trunk Bark Extracts of Cordyla pinnata (Lepr. Ex A. Rich.) Milne-Redh. (Caesalpiniaceae)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cordyla pinnata</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical screening</style></keyword><keyword><style  face="normal" font="default" size="100%">Trunk bark</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1415-1418</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The aim of this study was to investigate the phytochemical composition and the antioxidant effect of ethanol leaf and trunk bark extracts of an African wild plant, &lt;em&gt;Cordyla pinnata&lt;/em&gt; (Lepr. Ex A. Rich.) Milne-Redh. C. pinnata is used in Senegalese folk medicine to treat asthenia, spasm and various infections. &lt;strong&gt;Methods: &lt;/strong&gt;The phytochemical investigation of the extracts was done using physico-chemical reactions while antioxidant effect was assessed by DPPH and FRAP assays. &lt;strong&gt;Results: &lt;/strong&gt;Tannins, flavonoids, cardiotonic heterosides and triterpenoids were present in leaf and trunk bark extracts of &lt;em&gt;C. pinnata&lt;/em&gt;. Meanwhile, anthracenic derivatives were detected in the leaf extract of &lt;em&gt;C. pinnata&lt;/em&gt;. In DPPH assay, IC&lt;sub&gt;50 &lt;/sub&gt;values of the leaf, trunk bark extracts and ascorbic acid were respectively 21.07 ± 0.11 μg/ml, 19.53 ± 0.42 μg/ml and 0.33 ± 0.11 μg/ml. In FRAP assay, the leaf and trunk bark extracts and ascorbic acid reduced significantly ferric ion. Ascorbic acid was seen to be more active in FRAP assay than the leaf and trunk bark extracts of&lt;em&gt; C. pinnata&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;Ethanol leaf and trunk bark extracts of &lt;em&gt;C. pinnata &lt;/em&gt;had revealed antioxidant activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1415</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Alioune Dior FALL&lt;sup&gt;1,&lt;/sup&gt;*, Serigne Ibra Mbacké DIENG&lt;sup&gt;1&lt;/sup&gt;, Abdou SARR&lt;sup&gt;1&lt;/sup&gt;, Mbaye DIENG&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy and Botany of the Faculty of Medicine, Pharmacy and Odontology of the Cheikh Anta Diop University of Dakar, SENEGAL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Imad M Al-Ani</style></author><author><style face="normal" font="default" size="100%">Norsidah Ku-Zaifah</style></author><author><style face="normal" font="default" size="100%">Fakhria A. Al-Joufi</style></author><author><style face="normal" font="default" size="100%">Rafidah H.Mokhtar</style></author><author><style face="normal" font="default" size="100%">Norlelawati A. Talib</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Eurycoma longifolia Jack Root Extract Against High-Fat Diet Induced Testicular Damage in Sprague-Dawley Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Eurycoma Longifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">High-Fat-Diet</style></keyword><keyword><style  face="normal" font="default" size="100%">Seminiferous Tubules Tongkat Ali</style></keyword><keyword><style  face="normal" font="default" size="100%">Testis</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">808-811</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aims of this study were to investigate the adverse effects of the high-fat-diet (HFD) on the testosterone level and testicular structure of male rats as well as to examine whether &lt;em&gt;Eurycoma longifolia&lt;/em&gt; (EL) is able to ameliorate these effects. &lt;strong&gt;Methods:&lt;/strong&gt; Twenty-four male Sprague-Dawley (SD) rats were divided into four groups each containing 6 rats. Group ND was given only normal diet, group NDEL was given normal diet and EL extracts (15 mg/ kg) dissolved in distilled water, group HFD was given only high-fat-diet and group HFDEL was given high-fat-diet and EL extracts (15 mg/kg). EL was administered orally for 12 weeks. The animal’s testosterone level was measured at week 0, 6 and 12. The rats were sacrificed at the end of 12&lt;sup&gt;th &lt;/sup&gt;weeks and the testes samples were processed for histological examination&lt;strong&gt; Results: &lt;/strong&gt;The testosterone level was significantly increased (&lt;em&gt;p&lt;/em&gt; &amp;lt; 0.05) in the in the treated rats with EL (NDEL and HFDEL) compared with ND and HFD groups. Treatment with HFD revealed a marked degeneration of the seminiferous tubule epithelium and disruption of interstitial cells of the testis thereby interfering with spermatogenesis. Treatment of HFD rats with El reduced the adverse effects of HFD and improved the morphological structure of the seminiferous tubules. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings revealed that EL has ameliorative effects against the testicular damage caused by high-fat-diet.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">808</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Imad M Al-Ani&lt;sup&gt;1&lt;/sup&gt;, Norsidah Ku-Zaifah&lt;sup&gt;2&lt;/sup&gt;, Fakhria A. Al- Joufi&lt;sup&gt;3&lt;/sup&gt;, Rafidah H.Mokhtar&lt;sup&gt;4&lt;/sup&gt;, Norlelawati A. Talib&lt;sup&gt;5&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;6,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Dentistry, Al-Hikmah University College, Al-Yarmook, Baghdad, IRAQ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Basic Medical Sciences, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;College of Pharmacy, Al Jouf University, Aljouf, Skaka KSA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Medicine, Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University, MALAYSIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Fundamental Dental and Medical sciences, Kulliyyah of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Al Mukhlas Fikri</style></author><author><style face="normal" font="default" size="100%">Ahmad Sulaeman</style></author><author><style face="normal" font="default" size="100%">Sri Anna Marliyati</style></author><author><style face="normal" font="default" size="100%">Mokhamad Fahrudin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiemetic Activity of Trigona spp. Propolis from Three Provinces of Indonesia with Two Methods of Extraction</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiemetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Propolis</style></keyword><keyword><style  face="normal" font="default" size="100%">Retching</style></keyword><keyword><style  face="normal" font="default" size="100%">Stingless bee</style></keyword><keyword><style  face="normal" font="default" size="100%">Trigona spp</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/407</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">120-122</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Propolis is a resinous substance collected by bees to protect their hives. One of the least explored function of propolis is its antiemetic activity. The present study aimed to investigate the antiemetic activity of &lt;em&gt;Trigona &lt;/em&gt;spp. propolis from three provinces of Indonesia. &lt;strong&gt;Methods:&lt;/strong&gt; Ultrasound-assisted extraction using two kinds of solvent, water and ethanol was conducted to extract propolis from South Sulawesi, South Kalimantan and Banten. Antiemetic activity was observed on copper sulfate&amp;ndash;induced emesis in young chicks. &lt;strong&gt;Result:&lt;/strong&gt; All propolis indicated antiemetic activity, in which water extract had higher activity than ethanol extract. Regardless the type of solvents, propolis from South Sulawesi showed higher antiemetic activity than others. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study demonstrated that propolis has antiemetic activity, in which propolis from South Sulawesi showed the highest activity and water extraction is recommended.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">120</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Al Mukhlas Fikri&lt;sup&gt;1&lt;/sup&gt;, Ahmad Sulaeman&lt;sup&gt;1&lt;/sup&gt;*, Sri Anna Marliyati&lt;sup&gt;1&lt;/sup&gt;, Mokhamad Fahrudin&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Community Nutrition, Faculty of Human Ecology, Bogor Agricultural University, Bogor 16680, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor 16680, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muhammad Ilyas Yusuf</style></author><author><style face="normal" font="default" size="100%">Wahyuni</style></author><author><style face="normal" font="default" size="100%">Sri Susanty</style></author><author><style face="normal" font="default" size="100%">Ruslan</style></author><author><style face="normal" font="default" size="100%">Muammar Fawwaz</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidant and Antidiabetic Potential of Galing Stem Extract (Cayratia trifolia Domin)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Galing stem</style></keyword><keyword><style  face="normal" font="default" size="100%">Mice</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/651</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">686-690</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;Galing (&lt;em&gt;Cayratia trifolia&lt;/em&gt; Domin.) have been used empirically to treat various diseases, one of them is antidiabetic. &lt;strong&gt;Objective:&lt;/strong&gt; To determine the phytochemical content and the activity of the ethanol extract of the galing stem as antioxidant and antidiabetic. &lt;strong&gt;Method:&lt;/strong&gt; The galing stem extract was investigated for phytochemical by Thin Layer Chromatography (TLC) and its antioxidant activity using DPPH scavenging activity assay. &lt;em&gt;In vivo,&lt;/em&gt; antidiabetic test was conducted by animal diabetes modeling that has given streptozotocin 150 g/kg BW and 10% of sucrose solution intraperitoneally. The average level of fasting blood glucose at 307 mg/dL. Mice were divided into 6 groups, normal control group, diabetes induction group, positive group (treated by glibenclamide) and treatment group consisted of three groups were treated by ethanol extract of galing stem in dose 400, 500, and 600 mg/kg BW, respectively. Mice treated with appropriate doses of each treatment once a day for 7 days. The measuring blood glucose level was using a photometer 5010V5+. &lt;strong&gt;Results:&lt;/strong&gt; The ethanol extract of galing stem contained the alkaloid, flavonoid, saponin, tannin, and triterpene. It is potential as an antioxidant with the IC&lt;sub&gt;50&lt;/sub&gt; 61,52 mg/L which indicated that the extract had strong antioxidant. The antidiabetic activity showed that the effect of extract 400 and 500 mg/kg BW are not different significantly with glibenclamide in reducing blood glucose levels subset of the statistics ANOVA (&lt;em&gt;p&lt;/em&gt;&amp;gt; 0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; The ethanol extract of galing steam is potent as an antioxidant due to the phytochemical content inside particularly the flavonoid compound.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">686</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Muhammad Ilyas Yusuf&lt;sup&gt;1&lt;/sup&gt;, Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Sri Susanty&lt;sup&gt;2&lt;/sup&gt;, Ruslan&lt;sup&gt;3&lt;/sup&gt;, Muammar Fawwaz&lt;sup&gt;4&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Universitas Haluoleo, Kendari, Southeast Sulawesi, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nursing, Faculty of Medicine, Universitas Haluoleo, Kendari, Southeast Sulawesi, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Mathematics, Faculty of Science, Universitas Haluoleo, Kendari, Southeast Sulawesi, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, South Sulawesi, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Oluwafemi Adeleke Ojo</style></author><author><style face="normal" font="default" size="100%">Basiru Olaitan Ajiboye</style></author><author><style face="normal" font="default" size="100%">Oluwatosin Debbie Imiere</style></author><author><style face="normal" font="default" size="100%">Oluwatosin Adeyonu</style></author><author><style face="normal" font="default" size="100%">Israel Olayide</style></author><author><style face="normal" font="default" size="100%">Adewale Fadaka</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antioxidative Properties of Blighia sapida K.D. Koenig Stem Bark Extract and Inhibitory Effects on Carbohydrate Hydrolyzing Enzymes Associated with Non-Insulin Dependent Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Blighia sapida K D Koenig</style></keyword><keyword><style  face="normal" font="default" size="100%">α-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/494</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">376-383</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; In Africa, the fruit, seed, leaf, and stem of &lt;em&gt;Blighia sapida&lt;/em&gt; K.D. Koenig are used as remedy for a range of diseases. This study characterized the phytochemicals, assessed the antioxidant and inhibitory properties of the stem bark of &lt;em&gt;Blighia sapida&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Samples were consecutively extracted using ethanol solvent and investigated for phenol content, DPPH radical scavenging abilities, iron chelation, reducing power, &amp;alpha;-amylase and &amp;alpha;-glucosidase activities as markers of &lt;em&gt;in vitro&lt;/em&gt; anti-diabetic activities. Phytochemicals were analyzed using gas chromatography-mass spectrometry (GC-MS) analysis. &lt;strong&gt;Results:&lt;/strong&gt; The extract had radical scavenging capabilities, iron chelation and reducing power. Furthermore, the results reveal the extract had considerably high &amp;alpha;-glucosidase and &amp;alpha;- amylase inhibitory activities as the concentration increases with IC&lt;sub&gt;50&lt;/sub&gt; values of 4.17 &amp;plusmn; 0.24 mg/mL and 5.30 &amp;plusmn; 1.25 mg/mL, respectively. Enzyme kinetic studies indicated that the extract displayed uncompetitive inhibitor for &amp;alpha;-glucosidase and was a competitive inhibitor of &amp;alpha;-amylase. The ethanolic extract is rich in several aromatic phenolic compounds and long chain aliphatic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results reveal the bark possessed antioxidant as well as &amp;alpha; -glucosidase and &amp;alpha; -amylase inhibitory activities.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">376</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Oluwafemi Adeleke Ojo*, Basiru Olaitan Ajiboye, Oluwatosin Debbie Imiere, Oluwatosin Adeyonu, Israel Olayide, Adewale Fadaka &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Phytomedicine, Biochemical Toxicology and Diabetes Research Laboratories, Department of Biochemistry, Afe Babalola University, Ado-Ekiti, Ekiti State, NIGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Juarez Henrique Ferreira</style></author><author><style face="normal" font="default" size="100%">Rafael Martinez Garcia</style></author><author><style face="normal" font="default" size="100%">Fariza Abrão</style></author><author><style face="normal" font="default" size="100%">Yadira Arnet Fernandez</style></author><author><style face="normal" font="default" size="100%">Regina Helena Pires</style></author><author><style face="normal" font="default" size="100%">Sérgio Ricardo Ambrósio</style></author><author><style face="normal" font="default" size="100%">Rodrigo Cassio Sola Veneziani</style></author><author><style face="normal" font="default" size="100%">Carlos Henrique Gomes Martins</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bactericidal Kinetics and Antibiofilm Efficacy of Pimarane-Type Diterpenes from Viguiera arenaria Against Cariogenic Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Bactericidal kinetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Scanning electron microscopy</style></keyword><keyword><style  face="normal" font="default" size="100%">Streptococcus mutans</style></keyword><keyword><style  face="normal" font="default" size="100%">Viguiera arenaria</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/503</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">429-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Dental caries is an infectious disease related to biofilm formation. Among the microorganisms presents in the oral microbiota, &lt;em&gt;Streptococcus mutans&lt;/em&gt; can form biofilm on the tooth surface in the presence of dietary carbohydrates. This study aimed to evaluate the bactericidal kinetics and antibiofilm efficacy of ent-pimara-8(14),15-dien-19-oic acid (compound 1) and ent-8(14),15-pimaradien-3&amp;beta;-ol (compound 2) obtained from &lt;em&gt;Viguiera arenaria &lt;/em&gt;against oral pathogens; this study also aimed to determine the effect of these compounds on the morphology and architecture of the &lt;em&gt;S. mutans&lt;/em&gt; biofilm by scanning electron microscopy (SEM). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The bactericidal kinetics revealed different results depending on the tested bacteria. Compound 1 eliminated the viable bacteria within 24 hs of incubation. In the antibiofilm assay, compound 1 displayed promising results against S. mitis (ATCC 49456 and clinical isolate) and &lt;em&gt;L. casei&lt;/em&gt; (clinical isolate), whereas compound 2 was not active at the evaluated concentrations. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compound 1 is an important metabolite in the search for new antibacterial agents against cariogenic bacteria both in the sessile and planktonic modes. The SEM image of &lt;em&gt;Streptococcus mutans&lt;/em&gt; in the presence of compound 1 suggested that this metabolite acts by disrupting the bacterial membrane disrupting the bacterial membrane and/or cell wall and causing microrganism death.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">429</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Juarez Henrique Ferreira&lt;sup&gt;1&lt;/sup&gt;, Rafael Martinez Garcia&lt;sup&gt;1&lt;/sup&gt;, Fariza Abr&amp;atilde;o&lt;sup&gt;1&lt;/sup&gt;, Yadira Arnet Fernandez&lt;sup&gt;1&lt;/sup&gt;, Regina Helena Pires&lt;sup&gt;1&lt;/sup&gt;, S&amp;eacute;rgio Ricardo Ambr&amp;oacute;sio&lt;sup&gt;2&lt;/sup&gt;, Rodrigo Cassio Sola Veneziani&lt;sup&gt;2&lt;/sup&gt;, Carlos Henrique Gomes Martins&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Laboratory of Applied Microbiology, University of Franca, Franca, SP, BRAZIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Nucleus of Research in Sciences and Technology, University of Franca, Franca, SP, BRAZIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarah Zielda Najib</style></author><author><style face="normal" font="default" size="100%">Wilzar Fachri</style></author><author><style face="normal" font="default" size="100%">Rani Sauriasari</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Raymond Tjandrawinata</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cholesterol-lowering Effects of Extract from Garcinia daedalanthera in Hyperlipidemic rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cholesterol</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal</style></keyword><keyword><style  face="normal" font="default" size="100%">In vivo</style></keyword><keyword><style  face="normal" font="default" size="100%">Pre-clinical study</style></keyword><keyword><style  face="normal" font="default" size="100%">Rat</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1125-1128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; A native plant from Indonesia, &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; has been scientifically proven have antidiabetic effects and antioxidant activity. We hypothesized that &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; can modulate the lipid profiles of hyperlipidemic rats. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to evaluate the antihyperlipidemic potential of &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; leaves extract (GDE) were orally administrated to high fat diet-induced rats for 15 days. After the end of experimental period (43 days) the lipid profiles were estimated along with histopathological liver examination of animals. &lt;strong&gt;Results:&lt;/strong&gt; The results showed that &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract significantly reduced the level of serum total cholesterol, total triglycerides and low-density lipoprotein as compared to control group with an increasing level of serum high-density lipoprotein. Furthermore, the extract has a favorable effect on histopathological study. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study proved antilipidemic property by lowering altered levels of lipid profile in male wistar rats and suggest lipid lowering effects of &lt;em&gt;Garcinia daedalanthera&lt;/em&gt; extract which serves as a new potential natural product for preventing hyperlipidemia.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1125</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sarah Zielda Najib&lt;sup&gt;1&lt;/sup&gt;,&amp;nbsp;Wilzar Fachri&lt;sup&gt;2&lt;/sup&gt;,&amp;nbsp;Rani Sauriasari&lt;sup&gt;1&lt;/sup&gt;*,&amp;nbsp;Berna Elya&lt;sup&gt;1&lt;/sup&gt;, Raymond Tjandrawinata&lt;sup&gt;3&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Depok, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, University of Indonesia, Salemba, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Dexa Laboratories of Biomolecular Sciences, Cikarang, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">NMU</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/359</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to evaluate the possible protective effect of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 &amp;mu;g/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 and &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the anti-inflammatory, antioxidant, and anticancer properties of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;2&lt;/sup&gt;*, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;3&lt;/sup&gt;, C&amp;eacute;sar Franco-Quino&lt;sup&gt;3&lt;/sup&gt;, Ren&amp;aacute;n Ha&amp;ntilde;ari-Quispe&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima. PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga de Ica, Ica, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Physiology and Pharmacology, Faculty of Dentistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Animal Physiology, Universidad &amp;Aacute;ndina N&amp;eacute;stor C&amp;aacute;ceres Vel&amp;aacute;squez, Puno, PERU.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Serebryanaya FK</style></author><author><style face="normal" font="default" size="100%">Sekinayeva MA</style></author><author><style face="normal" font="default" size="100%">Denisenko ON</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Micromorphological Investigations of Red Godji Berries (Lycium barbarum L.) and Black Godji Berries (Lycium ruthenicum Murr.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromoplastes</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruits</style></keyword><keyword><style  face="normal" font="default" size="100%">Lycium barbarum L</style></keyword><keyword><style  face="normal" font="default" size="100%">Lycium ruthenicum</style></keyword><keyword><style  face="normal" font="default" size="100%">Micro-diagnostic features</style></keyword><keyword><style  face="normal" font="default" size="100%">Seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Testa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">911-915</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The comparative morphological and anatomical research of the fruits and seeds of two species of the genre&lt;em&gt; Lycium&lt;/em&gt; is conducted. An objective of this research was carrying out comparative studying of anatomical diagnostic signs of fruits of a red Godjy berries (&lt;em&gt;Lycium barbarum&lt;/em&gt; L.) and black Godjy berries (&lt;em&gt;Lycium ruthenicum&lt;/em&gt; murr.) for establishment of authenticity of medicinal vegetable raw materials. This work is a fragment of complex researches of plants of flora of the North Caucasus and also introduced species. Because of the conducted comparative this research the main signs allowing to carry out identification of medicinal vegetable raw materials both in integral and in the crushed look are revealed. The conducted researches can be used further for development of normative documentation on raw materials of these species.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">911</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Serebryanaya FK, Sekinaeva MA, Denisenko ON &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Pyatigorsk Medical and Pharmaceutical Institute-Branch of Volgograd State Medical University of Russian Ministry of Health (357532, Pyatigorsk, av. Kalinina,11), RUSSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Serebryanaya FK</style></author><author><style face="normal" font="default" size="100%">Sekinayeva MA</style></author><author><style face="normal" font="default" size="100%">Denisenko ON</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Micromorphological Investigations of Red Godji Berries (Lycium barbarum L.) and Black Godji Berries (Lycium ruthenicum Murr.)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The comparative morphological and anatomical research of the fruits and seeds of two species of the genre Lycium is conducted. An objective of this research was carrying out comparative studying of anatomical diagnostic signs of fruits of a red Godjy berries (&lt;em&gt;Lycium barbarum&lt;/em&gt; L.) and black Godjy berries (&lt;em&gt;Lycium ruthenicum&lt;/em&gt; murr.) for establishment of authenticity of medicinal vegetable raw materials. This work is a fragment of complex researches of plants of flora of the North Caucasus and also introduced species. Because of the conducted comparative this research the main signs allowing to carry out identification of medicinal vegetable raw materials both in integral and in the crushed look are revealed. The conducted researches can be used further for development of normative documentation on raw materials of these species.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt; Key Words:&lt;/strong&gt; &lt;em&gt;Lycium barbarum&lt;/em&gt; L, &lt;em&gt;Lycium ruthenicum&lt;/em&gt;, Micro-diagnostic features, Fruits, Seeds, Testa, Chromoplastes..&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sekinaeva MA, Denisenko ON &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Pyatigorsk Medical and Pharmaceutical Institute-Branch of Volgograd State Medical University of Russian Ministry of Health (357532, Pyatigorsk, av. Kalinina,11)&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ghazi Faisal Najmuldeen</style></author><author><style face="normal" font="default" size="100%">Kamalanathan  Narayanan</style></author><author><style face="normal" font="default" size="100%">Deeveeya A/P Kirubananthan</style></author><author><style face="normal" font="default" size="100%">Ghasak Ghazi Faisal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparison of Tongkat Ali Root Chemical Composition Extracted by Soxhlet, Conventional Steam and Microwave Assisted Extraction Techniques</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Conventional Steam Extraction (CSE)</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Eurycoma longifolia Jack</style></keyword><keyword><style  face="normal" font="default" size="100%">Microwave assisted extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Soxhlet Extraction</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">916-920</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Eurycoma longifolia Jack (Tongkat Ali) roots are used in traditional medicines for its wide range of biological effects. The process of extracting out this essential oil from the plant requires a delicate and efficient method. In this research the extract of the essential oil of &lt;em&gt;Eurycoma longifolia&amp;rsquo;s&lt;/em&gt; root using Microwave Assisted Extraction (MAE), Soxhlet Extraction and Conventional Steam Extraction (CSE) methods, is characterized to identify the components of essential oil extracted and then to compare the yield percentage and components of the extracts from both methods. The extract obtained was characterized using gas chromatography mass spectroscopy (GC-MS) by comparing the compositions of components present in commercial Tongkat Ali oil stored in the GC-MS library. The findings showed that the MAE gives a maximum yield percentage of 5% with six chemical components extracted in 20 min while SE and CSE gives high yield percentage of 28.3% in 3 h and 2.5 % in 6 h respectively with only three chemical components extracted. Therefore, MAE is the optimum method for extracting essential oil from Tongkat Ali with a high quality.&lt;/p&gt;
&lt;p&gt;&amp;nbsp;&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">916</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ghazi Faisal Najmuldeen&lt;sup&gt;1&lt;/sup&gt;, Kamalanathan  Narayanan&lt;sup&gt;1&lt;/sup&gt;, Deeveeya A/P Kirubananthan&lt;sup&gt;1&lt;/sup&gt;, Ghasak Ghazi Faisal&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Chemical and Natural Resources Engineering, University Malaysia Pahang, 26300 Gambang, Pahang, MALAYSIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Fundamental Dental and Medical Sciences, Kulliyya of Dentistry, International Islamic University, MALAYSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramdan Btissam</style></author><author><style face="normal" font="default" size="100%">El Malki Fatima</style></author><author><style face="normal" font="default" size="100%">Eddarraji Kamal</style></author><author><style face="normal" font="default" size="100%">Greche Hassane</style></author><author><style face="normal" font="default" size="100%">NHIRI Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Composition and Antibacterial Activity of Hydro-Alcohol and Aqueous Extracts Obtained from the Lamiaceae Family</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Aqueous Extract.</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoic Content</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydro-Alcohol Extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Lamiaceae Family</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenolic compounds</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/402</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">81-91</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Plant from the &lt;em&gt;Lamiaceae&lt;/em&gt; family are considered as dietary spices and medicinal herbs traditionally used in medicine for the treatment of several pathologies. &lt;strong&gt;Objective:&lt;/strong&gt; Evaluation of the &lt;em&gt;in vitro&lt;/em&gt; antibacterial activity of ethanol and aqueous extracts of nine Moroccan plants from the Lamiaceae family against six bacterial strains regularly implicated in toxiinfection. &lt;strong&gt;Method:&lt;/strong&gt; The antibacterial activities of hot (HAE), cold (CAE) aqueous extracts and ethanolic extracts (EE) were evaluated using agar-well diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and IC&lt;sub&gt;50&lt;/sub&gt; against six foodborne bacteria (&lt;em&gt;Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa&lt;/em&gt; and &lt;em&gt;Salmonella enterica&lt;/em&gt;). Total phenolic and flavonoid contents were assessed as well. &lt;strong&gt;Results:&lt;/strong&gt; In the present study, the ethanol extracts were rich in polyphenols, with middling values of flavonoids, and relatively poor in condensed tannins. The presence of saponins, essential oils, irroides, alkaloids, anthocyanins, and aldehydes was recorded. The effect of the extracts was directly bactericidal for &lt;em&gt;B. cereus&lt;/em&gt; and &lt;em&gt;L. monocytogenes&lt;/em&gt;; for the other strains, the MBC value was twice higher than that of MIC. However, the ethanol extract (EE) of &lt;em&gt;O. majorana&lt;/em&gt; and &lt;em&gt;T. satureioides &lt;/em&gt;showed the highest antibacterial activity. With the principal component analysis, it was demonstrated that the nine &lt;em&gt;Lamiaceae&lt;/em&gt; family plants possess a powerful antibacterial effect, correlated with their phenolic content. &lt;strong&gt;Statistical analysis:&lt;/strong&gt; Analysis of variance was performed by uni-varied ANOVA in the software SPSS 22 Fr. &lt;strong&gt;Conclusion:&lt;/strong&gt; The active compounds were thermostable and soluble in ethanol and water. The antimicrobial activities of the plants extracts investigated may contribute to understand their involvement in traditional medicine against many microbial infections.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">81</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ramdan Btissam&lt;sup&gt;1&lt;/sup&gt;, El Malki Fatima&lt;sup&gt;2&lt;/sup&gt;, Eddarraji Kamal&lt;sup&gt;1,2&lt;/sup&gt;, Greche Hassane&lt;sup&gt;3&lt;/sup&gt; and Nhiri Mohamed&lt;sup&gt;1&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Biology, Laboratory of Biochemistry and Molecular Genetics, Faculty of Science and Technology, University Abdelmalek Essaadi, BP 416, Tangier 90000, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Microbiology, Department of Hygiene and Food Safety, Pasteur Institute of Morocco, Tangier 90000, MOROCCO.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;National Institute of Medicinal and Aromatic Plants, University of Sidi Mohamed Ben Abdellah, BP 8857, 30100 Atlas, Fes, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Diah Lia Aulifa</style></author><author><style face="normal" font="default" size="100%">Yessi Febriani</style></author><author><style face="normal" font="default" size="100%">Emi Sapitri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Correlation of Total Phenolic, Flavonoid and Carotenoid Content of Phyllanthus emblica Extract from Bandung with DPPH Scavenging Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Crotenoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllantus emblica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/506</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">447-452</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Many potential compounds have antioxidant activity, such as the flavonoid group, phenolics and carotenoids. &lt;em&gt;Phyllanthus emblica&lt;/em&gt; is widespread in Bandung-Indonesia and is a very potent as an antioxidant activity. Antioxidant activity and correlation with total flavonoids, phenolics and carotenoids from Phyllantus extract from Bandung-Indonesia have not been reported. The aim of this research were to determine the antioxidant activity from extract of various parts of &lt;em&gt;P. emblica&lt;/em&gt; and its correlation of antioxidant activity with the total flavonoid, phenolics and carotenoid. &lt;strong&gt;Method:&lt;/strong&gt; Successive extractions of various part of &lt;em&gt;P.emblica&lt;/em&gt; were performed by maceration using differrent polarity solvent n-hexane, ethyl acetate and ethanol. The antioxidant activity of each extracts was performed using DPPH (2.2-Diphenyl-1-Picrylhydrazil) method. The determination of total flavonoids, phenolics and carotenoids were performed by UV-Spectrophotometry. Antioxidant activity was demonstrated by IC&lt;sub&gt;50&lt;/sub&gt; and its correlation to total flavonoids, phenolics and carotenoids using the Pearson&amp;rsquo;s method. &lt;strong&gt;Result:&lt;/strong&gt; The highest antioxidant activity was given by fruit ethyl acetate (BE) extract with IC&lt;sub&gt;50&lt;/sub&gt; 3.032 &amp;mu;g/mL. Etyl acetate extract of stem bark &lt;em&gt;P.emblica&lt;/em&gt; (KE) had the highest of total phenol content (12.818 g GAE/100 g), ethanol extract of leaves &lt;em&gt;P.emblica&lt;/em&gt; (DO) had the highest of total flavonoid content (3.594 g QE/100 g), and n-hexane extract of leave (DN) had the highest of total carotenoid content (0.759 g BE/100 g). &lt;strong&gt;Conclusion:&lt;/strong&gt; According to coeficient correlation Pearson&amp;rsquo;s between P. emblica extract with IC50 of DPPH scavengging activities, suggested that flavonoid and phenolic compound in stem bark extract and leaves extract of P. emblica were contributor major in its antioxidant activity with DPPH methode, and its same with carotenoid content in leaves extract of P. emblica.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">447</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sani Nurlaela Fitriansyah&lt;sup&gt;*&lt;/sup&gt;, Diah Lia Aulifa, Yessi Febriani, Emi Sapitri &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Indonesia School of Pharmacy, JI Soekarno Hatta no.354, Bandung, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Islamudin Ahmad</style></author><author><style face="normal" font="default" size="100%">Desta Andriyani</style></author><author><style face="normal" font="default" size="100%">Christoper Gunawan</style></author><author><style face="normal" font="default" size="100%">Nisrina Dhiah Fauziah</style></author><author><style face="normal" font="default" size="100%">Sutriyo Sutriyo</style></author><author><style face="normal" font="default" size="100%">Abdul Mun’im</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Food Processing on Resveratrol and Total Phenolic Content in Melinjo (Gnetum gnemon L.) Seeds</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Food processing</style></keyword><keyword><style  face="normal" font="default" size="100%">Gnetum gnemon L.</style></keyword><keyword><style  face="normal" font="default" size="100%">Melinjo seeds</style></keyword><keyword><style  face="normal" font="default" size="100%">Resveratrol levels</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1096-1100</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; &lt;em&gt;Trans&lt;/em&gt;-resveratrol is a phenolic compound in the stilbene group present in Melinjo (&lt;em&gt;Gnetum gnemon&lt;/em&gt; L.) seeds. In Indonesia, these seeds are consumed by roasting, frying (i.e., emping), and boiling. This study aimed to evaluate the effects of food processing on trans-resveratrol and total phenolic compound levels in melinjo seeds. &lt;strong&gt;Methods:&lt;/strong&gt; Melinjo seed was roasted at 145&lt;sup&gt;o&lt;/sup&gt;C for 10 and 20 min, boiled at 100&lt;sup&gt;o&lt;/sup&gt;C for 5, 15, and 30 min, and fried at 160-170&lt;sup&gt;o&lt;/sup&gt;C for 2 and 4 min. Samples were refluxed with 96% ethanol. The determination of&lt;em&gt; trans&lt;/em&gt;-resveratrol levels was performed using high-performance liquid chromatography (HPLC), and total phenolic content was determined using Folin-Ciocalteu method. &lt;strong&gt;Results:&lt;/strong&gt; Based on the results, it was found that &lt;em&gt;trans&lt;/em&gt;-resveratrol and total phenolic content levels in Melinjo powder decreased from 36% to 10% (&lt;em&gt;trans&lt;/em&gt;-resveratrol) and 15% to 4% (total phenolic) after 20 min of roasting, and in fried empings, it decreased 60%, 68%, and 92% (&lt;em&gt;trans&lt;/em&gt;-resveratrol) and 41%, 45%, 97% (total phenolic) after 5, 15, and 30 min of boiling, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; There were significant changes in trans-resveratrol levels and total phenolic content in Melinjo seeds before and after various cooking processes (i.e., roasting, boiling, and frying).&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1096</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Islamudin Ahmad&lt;sup&gt;1&lt;/sup&gt;, Desta Andriyani&lt;sup&gt;2&lt;/sup&gt;, Christoper Gunawan&lt;sup&gt;2&lt;/sup&gt;, Nisrina Dhiah Fauziah&lt;sup&gt;2&lt;/sup&gt;, Sutriyo Sutriyo&lt;sup&gt;3&lt;/sup&gt;, Abdul Mun&amp;rsquo;im&lt;sup&gt;2,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmaceutical Research and Development of FARMAKA TROPIS, Faculty of Pharmacy, Mulawarman University, Samarinda, East Kalimantan, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pharmaceutics, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Victoria Vladimirovna Fedotova</style></author><author><style face="normal" font="default" size="100%">Dmitry Alexeevich Konovalov</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Essential Oil and Anatomical Study of Flowers Solidago caucasica Kem.-Nath.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Chromoplasts</style></keyword><keyword><style  face="normal" font="default" size="100%">Humulene epoxide</style></keyword><keyword><style  face="normal" font="default" size="100%">Pathulenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Solidago caucasica Kem.-Nath.</style></keyword><keyword><style  face="normal" font="default" size="100%">Trichomes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s63-s65</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Plant &lt;em&gt;Solidago caucasica&lt;/em&gt; Kem.-Nath. (Asteraceae) is studied by us for the first time. We have established its diuretic and antimicrobial action. The study of essential oil and the anatomical structure of &lt;em&gt;S. caucasica&lt;/em&gt; flowers is presented for the first time in this article.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; &lt;em&gt;S. caucasica&lt;/em&gt; flowers were collected at the beginning of flowering in the botanical garden of the Pyatigorsk Medical and Pharmaceutical Institute. Essential oil was obtained by hydro distillation. The component composition of the essential oil was studied by liquid chromatography&amp;ndash;mass spectrometry. Results: The main components of essential oil and microscopic diagnostic signs of &lt;em&gt;S. caucasica&lt;/em&gt; flowers were established. &lt;em&gt;Solidago&lt;/em&gt; &lt;em&gt;caucasica&lt;/em&gt; flowers contain 0.57% essential oil. It contains humulene epoxide H (-)-spathulenol, &amp;beta;-linalool, &amp;alpha;-terpinol, trans-geraniol, carvacrol and others. Numerous pappus hairs meet in the microscopy of the flower. Ligulate florets are characterized by round chromoplasts, covering trichomes multicellular. Epidermal cells of the tubular florets have polygonal chromoplasts, trichomes, consisting of several cells fused with each other, covering trichomes with a thick wall and a thin cavity inside. On the epidermis of the involucre there are stomata of anomocytic type, glandular trichomes, trichomes cone-shaped, trichomes wide and essential oil glands. &lt;strong&gt;Conclusion:&lt;/strong&gt; The obtained standards will provide referential information for correct identification, purity, standardization and preparation of monograph of&lt;em&gt; S. caucasica&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s63</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Victoria Vladimirovna Fedotova, Dmitry Alexeevich Konovalov&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacognosy and Botany, Pyatigorsk Medical and Pharmaceutical Institute, A Branch of Volgograd State Medical University, Ministry of Health of Russian Federation, Pyatigorsk, 357532, Kalinina 11, RUSSIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">María C. Flechas</style></author><author><style face="normal" font="default" size="100%">Raquel E. Ocazionez</style></author><author><style face="normal" font="default" size="100%">Elena E. Stashenko</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of in vitro Antiviral Activity of Essential Oil Compounds Against Dengue Virus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiviral</style></keyword><keyword><style  face="normal" font="default" size="100%">Dengue</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavivirus</style></keyword><keyword><style  face="normal" font="default" size="100%">Terpene</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/366</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">55-59</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; There are not effective drugs available for treatment of dengue fever despite intensive research on synthetic inhibitors. The search for active phytochemicals could serve for the discovery of new drugs. This study aims to evaluate the antiviral activity&lt;em&gt; in vitro&lt;/em&gt; of compounds found in essential oils from medicinal plants. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Nine synthetic-derived essential oil compounds were evaluated. Antiviral effect was screened measuring the reduction of viral NS1 and E proteins in HepG-2 and Vero cells. Results: &amp;beta;-Caryophyllene was identified as the most active compound, it reduced the virus serotype-2 replication in HepG-2 cells at IC&lt;sub&gt;50&lt;/sub&gt; of 22 &amp;plusmn; 5.6 &amp;mu;M, and blocked replication of all four serotypes in Vero cells at IC&lt;sub&gt;50&lt;/sub&gt; between 8.0 &amp;mu;M and 15.0 &amp;mu;M. The selectivity indexes were between 5.3 and 10. According to results from time-in-addition assays, the antiviral effect of &amp;beta;-caryophyllene appears to be associated with interruption of early steps of the virus life cycle. Citral revealed modest antiviral effect, it reduced the virus serotype-2 (IC&lt;sub&gt;50&lt;/sub&gt; of 31 &amp;plusmn; 4.5 &amp;mu;M) replication but not the other three serotypes. Seven terpenes did not reveal antiviral activity at maximum concentration of 30 &amp;mu;M. &lt;strong&gt;Conclusion:&lt;/strong&gt; Research on compounds found in essential oils can contribute to the drug discovery effort for dengue. &amp;beta;-Caryophyllene could serve as a starting point.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">55</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Mar&amp;iacute;a C. Flechas, Raquel E. Ocazionez*, Elena E. Stashenko &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Centro de Investigaciones en Enfermedades Tropicales (CINTROP) and Centro de Investigaci&amp;oacute;n en Biomol&amp;eacute;culas (CIBIMOL), Universidad Industrial de Santander, Bucaramanga, COLOMBIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation and in vivo Effect of Essential Oil from Cinnamommum burmannii as Anti-obesity with Leptin Receptor in the Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamomum burmannii</style></keyword><keyword><style  face="normal" font="default" size="100%">docking simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">immunohistochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">leptin receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">olfactory system</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">875-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice Balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both &lt;em&gt;in silico&lt;/em&gt; and &lt;em&gt;in vivo&lt;/em&gt; evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">875</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Aryo Tedjo&lt;sup&gt;2&lt;/sup&gt;, Fadilah Fadilah&lt;sup&gt;2&lt;/sup&gt;, Ade Arsianti&lt;sup&gt;2&lt;/sup&gt;, Rafika Indah Paramita&lt;sup&gt;2*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Aryo Tedjo</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Ade Arsianti</style></author><author><style face="normal" font="default" size="100%">Rafika Indah Paramita</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification by Docking Simulation And In Vivo Effect of Essential Oil From Cinnamommum Burmannii as Antiobesity With Leptin Receptor In The Olfactory System of Mice Balb C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; This study examines the effect of inhalation of essential oil of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) on the metabolic activity of hormone receptors olfactory system of mice balb C. &lt;strong&gt;Methodology:&lt;/strong&gt; Effects of agonist or antagonist compounds in cinnamon essential oil on metabolic hormone receptors in the olfactory system are predicted using molecular docking simulation. Changes in the metabolic processes that occur views of changes in body weight, change in food intake, as well as lipid profile and blood glucose of mice. &lt;strong&gt;Result:&lt;/strong&gt; The results showed Expression of leptin receptors (Lep-R) in the brains of mice given either inhalation of essential oils derived from the leaves and stems, in contrast to the control group who did not get essential oils. Provision of essential oils through inhalation increased lep-R expression in the brain of mice. Both in silico and in vivo evidence that essential oils from cinnamon plants are extracted from &lt;em&gt;Cinnamommum burmannii&lt;/em&gt; and given by inhalation in Balb C mice are known to improve glucose and lipid metabolism by reducing the concentration of serum leptin concentrations and increased sensitivity to insulin.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt; olfactory system, leptin receptors, &lt;em&gt;Cinnamomum burmannii&lt;/em&gt;, docking simulation, immunohistochemistry&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi,1 Aryo Tedjo,&lt;sup&gt;2&lt;/sup&gt; Fadilah Fadilah,&lt;sup&gt;2&lt;/sup&gt; Ade Arsianti,&lt;sup&gt;2&lt;/sup&gt; Rafika Indah Paramita&lt;sup&gt;2&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 1&lt;/sup&gt;Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt; 2&lt;/sup&gt;Department of Medical Chemistry, Drug Development Research Center - IMERI, Faculty of Medicine, University of Indonesia, Jakarta - 10430, INDONESIA. *e-mail : fika.paramita@gmail.com / rafikaindah@ ui.ac.id&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kusmardi Kusmardi</style></author><author><style face="normal" font="default" size="100%">Tedjo Aryo</style></author><author><style face="normal" font="default" size="100%">Wuyung Puspita Eka</style></author><author><style face="normal" font="default" size="100%">Fadilah Fadilah</style></author><author><style face="normal" font="default" size="100%">Priosoeryanto Bambang Pontjo</style></author><author><style face="normal" font="default" size="100%">Fachri Wilzar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico, in vitro and in vivo Tests of Ficus deltoidea Jack Leaves Extract as Inhibitor for Beta-Catenin Expression in Colon Carcinogenesis Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Azoxymethane</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon carcinogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ficus deltoidea</style></keyword><keyword><style  face="normal" font="default" size="100%">in silico</style></keyword><keyword><style  face="normal" font="default" size="100%">β-catenin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/675</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">808-813</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; &lt;em&gt;Ficus deltoidea&lt;/em&gt; Jack leaves extract as anticolorectal cancer. &lt;strong&gt;Aims:&lt;/strong&gt; This study aims to analyze the potential of FD extract to be an anti-colon cancer by investigating the extract capability in reducing &amp;beta;-catenin expression and inhibiting colon cancer cells growth. &lt;strong&gt;Settings |and Design:&lt;/strong&gt; The research was conducted in Medical Faculty Universitas Indonesia with experimental design. &lt;strong&gt;Methods and Material:&lt;/strong&gt; FD ethanol extracts was tested in vitro, in silico and &lt;em&gt;in vivo&lt;/em&gt;. &lt;em&gt;In vitro&lt;/em&gt; test was conducted to human colon cell lines. &lt;em&gt;In vivo&lt;/em&gt; test was conducted to Balb/c mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). The colonic tissue collected was the distal portion. &amp;beta;-catenin expressions in the cytoplasm and nuclei of the epithelial cells of the colon crypt were semi quantitatively assessed using the immunohistochemistry staining on ten visual fields with 400x magnification. &lt;strong&gt;Statistical analysis used:&lt;/strong&gt; SPSS. &lt;strong&gt;Results:&lt;/strong&gt; FD ethanol extracts inhibit the expression of &amp;beta;-catenin in the crypt ephitelial cells of mice colon induced with AOM/DSS. The extracts also inhibit the growth of human colon cancer (HCT 116) with IC&lt;sub&gt;50&lt;/sub&gt; value of 5.41 mg/mL. Phytochemical screening to the extracts gave three groups of compounds: alkaloid, flavonoid, and tannin. Water fraction is the best fraction. Based on in the results of in silico analysis with molecular docking, FD extract is believed to influence the expression of &amp;beta;-catenin, in which vitexin and isovitexin are the main candidate compounds to influence the expression of the protein. &lt;strong&gt;Conclusion:&lt;/strong&gt; FD ethanol extract is potential to be an anti-colon cancer proven by the extract capability to reduce &amp;beta;-catenin expression.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">808</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Kusmardi Kusmardi&lt;sup&gt;1&lt;/sup&gt;, Tedjo Aryo&lt;sup&gt;2&lt;/sup&gt;, Wuyung Puspita Eka&lt;sup&gt;1&lt;/sup&gt;, Fadilah&lt;sup&gt;2&lt;/sup&gt;, Priosoeryanto Bambang Pontjo&lt;sup&gt;3&lt;/sup&gt;, Fachri Wilzar&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;4&lt;/strong&gt;* &lt;/sup&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Deparment of Chemisty, Faculty of Medicine Universitas Indonesia, Jakarta, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Pathology, Faculty of Veterinary, Institut Pertanian Bogor, Bogor, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Drug Development Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ramdan Btissam</style></author><author><style face="normal" font="default" size="100%">E I Malki Fatima</style></author><author><style face="normal" font="default" size="100%">NHIRI Mohamed</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Study of Antibacterial Activity of Hydro-Alcohol Morrocan Plants Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydro-Alcohol Extract</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/518</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">519-526</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; Several aromatic and medicinal Morrocan plants have been used traditionally in pharmaceutical products and traditional medicine for the treatment of several pathologies. &lt;strong&gt;Objective:&lt;/strong&gt; Evaluation of the protective power of nine Moroccan plants ethanol extracts against some strains of bacteria. &lt;strong&gt;Method:&lt;/strong&gt; The antibacterial activities of ethanolic extracts (EE) were evaluated using agar-well diffusion method, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and IC&lt;sub&gt;50&lt;/sub&gt; against nine foodborne bacteria [&lt;em&gt;Bacillus cereus, Listeria monocytogenes, Staphylococcus aureus (PN15 and 25923&lt;/em&gt;), &lt;em&gt;Escherichia coli (TF2 and ATCC 25929), Pseudomonas aeruginosa (P116 and 195) and Salmonella enterica].&lt;/em&gt; Screening of chemical constituents was carried out as well. &lt;strong&gt;Results:&lt;/strong&gt; We noted the presence of leuco-anthocyanins, anthocyanins, essential oils, alkaloids, and aldehydes in the extracts. The strains of &lt;em&gt;S. enterica&lt;/em&gt; followed by &lt;em&gt;S. aureus&lt;/em&gt; and &lt;em&gt;P. aeruginosa&lt;/em&gt; were the most resistants to the extracts effect. The principal component analysis (APC) demonstrated that the highest antibacterial activity was that of &lt;em&gt;L. nobilis and O. europaea &lt;/em&gt;ethanol extract (EE), which was directly bactericidal on all the strains tested with the exception of &lt;em&gt;P. aeruginosa&lt;/em&gt;. While, &lt;em&gt;R. tinctorum, S. indicum and L. sativum&lt;/em&gt; were characterized by the lowest activity. &lt;strong&gt;Statistical analysis:&lt;/strong&gt; Analysis of variance was performed by uni-varied ANOVA in the software SPSS 22 Fr. &lt;strong&gt;Conclusion:&lt;/strong&gt; The active compounds were soluble in ethanol. The antimicrobial activities of &lt;em&gt;L. nobilis and O. europaea&lt;/em&gt; may contribute to understand their involvement in pharmaceutical products and traditional medicine against many microbial infections.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">519</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Ramdan Btissam&lt;sup&gt;1&lt;/sup&gt;, E I Malki Fatima&lt;sup&gt;2&lt;/sup&gt;, Nhiri Mohamed&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Laboratory of Biochemistry and Molecular Genetics, Faculty of Science and Technology, University Abdelmalek Essaadi, BP 416, Tangier 90000, MOROCCO.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Higher Institute of Nursing Professions and Health Techniques of Tetouan, Annex- Tangier, Marchan 90000 Tangier, MOROCCO.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Diah Lia Aulifa</style></author><author><style face="normal" font="default" size="100%">Sani Nurlaela Fitriansyah</style></author><author><style face="normal" font="default" size="100%">Seno Aulia Ardiansyah</style></author><author><style face="normal" font="default" size="100%">Diki Prayugo Wibowo</style></author><author><style face="normal" font="default" size="100%">Yolanda Armiliani Julata</style></author><author><style face="normal" font="default" size="100%">Desty Santi Christy</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening, Antibacterial Activity, and Mode of Action on Morus nigra</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cellular membrane damage.</style></keyword><keyword><style  face="normal" font="default" size="100%">Morus nigra</style></keyword><keyword><style  face="normal" font="default" size="100%">Propionibacterium Acnes</style></keyword><keyword><style  face="normal" font="default" size="100%">Staphylococcus Epidermidis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/414</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">167-171</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The &lt;em&gt;Morus nigra&lt;/em&gt; (&lt;em&gt;Moraceae&lt;/em&gt;) known as black mulberry is a well-grown plant in Lembang, Indonesia. Previous studies showed that black mulberry fruit has activity as antibacterial and antioxidant. The aims of this study were to evaluate the antibacterial effect of ethanol extract from stem bark, fruit, and leaves of &lt;em&gt;Morus nigra&lt;/em&gt;, MIC and morphological changes of the most active extract against &lt;em&gt;Staphylococcus epidermidis&lt;/em&gt; and &lt;em&gt;Propionibacterium acnes&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Agar diffusion and microdilution assays were used to evaluate the antibacterial effect of the extract by measuring the zone of inhibition and the minimum inhibitory concentration (MIC) of the extract against the test bacteria. Scanning electron microscopy (SEM) was performed to evaluate the morphological changes induced by the extract in cellular membrane of the bacteria. Protein and ion leakage from the bacterial cells induced by the extract were also evaluated. &lt;strong&gt;Results:&lt;/strong&gt; The antibacterial activity showed the most active extract was an ethanol extract of the stem bark against &lt;em&gt;S. epidermidis&lt;/em&gt; and &lt;em&gt;P. acnes&lt;/em&gt; with MIC value 4 mg/ml and 2 mg/ml, respectively. The extract also induced protein and ion leakage in test bacterial cells. SEM findings revealed that the extract induced potential cellular membrane damage in 4xMIC.&lt;strong&gt; Conclusion:&lt;/strong&gt; The antibacterial activity was related to the damaged of bacterial cell wall.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">167</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Diah Lia Aulifa*&lt;sup&gt;1&lt;/sup&gt;, Sani Nurlaela Fitriansyah&lt;sup&gt;1&lt;/sup&gt;, Seno Aulia Ardiansyah&lt;sup&gt;2&lt;/sup&gt;, Diki Prayugo Wibowo&lt;sup&gt;1&lt;/sup&gt;, Yolanda Armiliani Julata&lt;sup&gt;1&lt;/sup&gt;, Desty Santi Christy&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmaceutical Biology, Sekolah Tinggi Farmasi Indonesia (Indonesian School of Pharmacy), Jl. Soekarno-Hatta No 354, Bandung 40266, West Java, INDONESIA.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sekolah Tinggi Farmasi Indonesia (Indonesian School of Pharmacy), Jl. Soekarno- Hatta No 354, Bandung 40266, West Java, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Berna Elya</style></author><author><style face="normal" font="default" size="100%">Basah Katrin</style></author><author><style face="normal" font="default" size="100%">Roshamur Cahyan Forestrania</style></author><author><style face="normal" font="default" size="100%">Rosmalena Sofyan</style></author><author><style face="normal" font="default" size="100%">Ryan Adi Chandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Alkaloid from Phoebe declinata Nees Leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Alkaloid</style></keyword><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic activity</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH</style></keyword><keyword><style  face="normal" font="default" size="100%">MCF-7 cell line.</style></keyword><keyword><style  face="normal" font="default" size="100%">Phoebe declinata nees</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/165</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">713-720</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Genus Phoebe have been reported to produce isoquinoline alkaloids as aporphines, noraporphines, and benzylisoquinolines. Many of these isolates exhibit diversified biological activities, including cytotoxic activity. &lt;strong&gt;Objective:&lt;/strong&gt; The objective of this study is to determine cytotoxic activity of compound isolated from &lt;em&gt;Phoebe declinata&lt;/em&gt; againts MCF-7 (breast cancer cell line). &lt;strong&gt;Methods:&lt;/strong&gt; Extraction was done by reflux using n-hexane, antioxidant activity measured by DPPH method and reducing power method, cytotoxic activity measured by MTT assay using MCF-7 cell line, struture eucidation was confirmed by NMR. &lt;strong&gt;Results:&lt;/strong&gt; The antioxidant activity measured using DPPH method for 1 and 2 showed IC&lt;sub&gt;50&lt;/sub&gt; value of 6.42 and 11.80 &amp;mu;g/mL respectively and using reducing power method for 1 and 2 showed IC&lt;sub&gt;50&lt;/sub&gt; value of 7.02 and 13.74 &amp;mu;g/mL respectively. Compound (1) and (2) exhibited cytotoxic activity against MCF-7 cells with an IC&lt;sub&gt;50&lt;/sub&gt; value of 82.978 and 93.179 &amp;mu;g/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; Compound (1) and (2) exhibited antioxidant activity and cytotoxic activity against MCF-7.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">713</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Berna Elya&lt;sup&gt;1,2*&lt;/sup&gt;, Basah Katrin&lt;sup&gt;1&lt;/sup&gt;, Roshamur Cahyan Forestrania&lt;sup&gt;1&lt;/sup&gt;, Rosmalena Sofyan&lt;sup&gt;3,&amp;nbsp;&lt;/sup&gt;Ryan Adi Chandra&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, University of Indonesia, Kampus UI Depok,16424.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Study on Natural Products, University of Indonesia, Kampus UI Depok,16424.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Faculty of Medicine, University of Indonesia, Kampus UI depok, 16424.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jia P. Marcellano</style></author><author><style face="normal" font="default" size="100%">Alyssa S. Collanto</style></author><author><style face="normal" font="default" size="100%">Rolly G. Fuentes</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antibacterial Activity of Endophytic Fungi Isolated from the Bark of Cinnamomum mercadoi</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Escherichia</style></keyword><keyword><style  face="normal" font="default" size="100%">Fusarium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.69</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">405-409</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Cinnamomum mercadoi&lt;/em&gt; is a medicinal tree endemic to the Philippines. &lt;em&gt;Cinnamomum &lt;/em&gt;species have been extensively studied for their endophytic fungi with pharmacological importance. This study aims to isolate and evaluate the antibacterial activity of endophytic fungi associated with the bark of &lt;em&gt;C. mercadoi&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Endophytic fungi were isolated from surface sterilized bark samples aseptically. The pure isolates were identified through their morphological characteristics. Agar plug diffusion assay was employed in the primary screening of their antibacterial activity against &lt;em&gt;Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Bacillus cereus&lt;/em&gt;, &lt;em&gt;Escherichia coli &lt;/em&gt;and&lt;em&gt; Pseudomonas aeruginosa.&lt;/em&gt; Four active endophytes were fermented and extracted with ethyl acetate (EtOAc). The antibacterial activity of the EtOAc extracts was screened using the disk diffusion assay. The minimum inhibitory activity (MIC) was evaluated using the microdilution method. &lt;strong&gt;Results:&lt;/strong&gt; Twelve (12) endophytes were isolated from the bark of &lt;em&gt;C. mercadoi&lt;/em&gt;. All endophytes exhibited antibacterial activity on at least one of the test pathogens. However, only two of the four endophytes subjected to the secondary screening showed wide-spectrum activity and inhibited the growth of all test bacteria. &lt;em&gt;Fusarium&lt;/em&gt; sp. 2 was identified to have the most promising activity with MIC values ranging from 2.1 - 4.2 mg/mL. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;C. mercadoi&lt;/em&gt; harbors endophytes, particularly &lt;em&gt;Fusarium&lt;/em&gt; sp. 2, which possess antibacterial activity and thus a potential source of antibacterial compounds.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">405</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jia P. Marcellano, Alyssa S. Collanto, Rolly G. Fuentes &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Division of Natural Sciences and Mathematics, University of the Philippines Visayas Tacloban College, 6500 Tacloban City, PHILIPPINES.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Siska Febria</style></author><author><style face="normal" font="default" size="100%">Dessy Arisanty</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Apoptosis Induction of Cervical Carcinoma HeLa Cells Line by Dichloromethane Fraction of the Rinds of Garcinia cowa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apoptosis induction</style></keyword><keyword><style  face="normal" font="default" size="100%">Carcinoma cells</style></keyword><keyword><style  face="normal" font="default" size="100%">Double stanining</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa Roxb.</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.76</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">475-478</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective&lt;/strong&gt;: This study aims to determine the apoptosis induction of HeLa cervical carcinoma cells death by dichloromethane fraction of the rinds of &lt;em&gt;Garcinia cowa &lt;/em&gt;Roxb&lt;em&gt;.&lt;/em&gt; &lt;strong&gt;Methods:&lt;/strong&gt; Apoptosis induction of HeLa cell line was observed using a double staining method. &lt;strong&gt;Results:&lt;/strong&gt; The result of double staining observation showed that an apoptosis occurs which marked with yellowish green fluorescence and cell fragmentation. The average percentage of apoptotic cells was higher in the treated variables (70.38%) compared to the control variables (12.26% ). Statistical analysis by Independent Sample T-Test showed apoptosis Sig. (2-tailed) = 0.000 (&amp;lt;0.025). &lt;strong&gt;Conclusion:&lt;/strong&gt; The dichloromethane fraction of G. cowa rind induces apoptosis in HeLa cervical cancer cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">475</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Siska Febria&lt;sup&gt;1&lt;/sup&gt;, Dessy Arisanty&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, Padang, West Sumatra, INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Andalas University, Padang, West Sumatra, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saffidine Karima</style></author><author><style face="normal" font="default" size="100%">Chirol Nadine</style></author><author><style face="normal" font="default" size="100%">Benayache Fadila</style></author><author><style face="normal" font="default" size="100%">Jay Maurice</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characterization and Distribution of Flavonoids from Flowers in Different Horticultural Types of Begonia.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Begonia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotype</style></keyword><keyword><style  face="normal" font="default" size="100%">Distribution</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/186</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">850-855</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The &lt;em&gt;begonias&lt;/em&gt; are ornamental plants known by the varied forms and colors of their flowers, as well as their decorative foliage. &lt;strong&gt;Objective:&lt;/strong&gt; This study attempts to characterize the flavonoids isolated from flower extracts of different horticultural cultivars of the genus &lt;em&gt;Begonia&lt;/em&gt;. &lt;strong&gt;Material and methods:&lt;/strong&gt; The compounds of the ethyl acetate and aqueous extracts were separated by chromatographic methods and identified by UV spectra and chemical techniques. &lt;strong&gt;Results:&lt;/strong&gt; The analysis allowed the characterization of flavonoids belonging to flavonol types in the free aglycones and glycoside forms of kaempferol and quercetin. On the other hand, fingerprinting analysis and quantification of major flavonoids of 184 cultivars were performed by high-performance liquid chromatography (HPLC). Among twenty five (25) components which were detected and separated: ten were corresponding to quercetin 3-Oglucosyl- rhamnoside (Rt=23.5), quercetin 3-O-glucoside (Rt=25), kaempferol 3-O-glucosylrhamnoside and its acylated derivative (Rt=32), kaempferol 3-O-glucoside (Rt=33), quercetin 3-O-p.coumaroyl-diglucoside (Rt=37), quercetin 3-O-P.coumaroyl-glucoside (Rt=40.5), quercetin (Rt=41.5), kaempferol and its acylated derivative (Rt=47). Only non-acylated glycosides of quercetin and kaempferol contributed to chemical variations among different cultivars based on the results of PCA. &lt;strong&gt;Conclusion:&lt;/strong&gt; The genus &lt;em&gt;Begonia&lt;/em&gt; is very heterogeneous and it is possible to distinguish several chemotypes whose differences rely on the complementarities between the metabolic pathways involved in the biosynthesis of glycosides of quercetin and kaempferol.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">850</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Saffidine Karima&lt;sup&gt;1*&lt;/sup&gt;, Chirol Nadine&lt;sup&gt;2&lt;/sup&gt;, Benayache Fadila&lt;sup&gt;3&lt;/sup&gt;, Jay Maurice&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicine, Faculty of Medicine, University Ferhat Abbas, S&amp;eacute;tif, ALGERIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Phytochemistry, University Claude Bernard-Lyon I, Villeurbanne, FRANCE.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;University Fr&amp;egrave;res Mentouri Constantine 1, Constantine, ALGERIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Daniel Rodrigo Cavalcante de Araújo</style></author><author><style face="normal" font="default" size="100%">Luís Cláudio Nascimento da Silva</style></author><author><style face="normal" font="default" size="100%">Wolfgang Harand</style></author><author><style face="normal" font="default" size="100%">Júlia Morais Fernandes</style></author><author><style face="normal" font="default" size="100%">Thaciane da Cunha Soares</style></author><author><style face="normal" font="default" size="100%">Silvana Maria Zucolotto Langassner</style></author><author><style face="normal" font="default" size="100%">Raquel Brandt Giordani</style></author><author><style face="normal" font="default" size="100%">Rafael Matos Ximenes</style></author><author><style face="normal" font="default" size="100%">Alexandre Gomes da Silva</style></author><author><style face="normal" font="default" size="100%">Márcia Vanusa da Silva</style></author><author><style face="normal" font="default" size="100%">Maria Tereza dos Santos Correia</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of Rainfall on the Antimicrobial Activity and Secondary Metabolites Contents of Leaves and Fruits of Anadenanthera colubrina from Caatinga Area.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial agents</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plants</style></keyword><keyword><style  face="normal" font="default" size="100%">Natural products</style></keyword><keyword><style  face="normal" font="default" size="100%">Semi arid area</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.73</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">435-440</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Anadenanthera colubrina&lt;/em&gt; (Vell.) Brenan var. cebil (Griseb) is a plant widely used for medicinal proposes in Brazilian Northeast. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to analyze the influence of rainfall indexes (RI) in antimicrobial activity and phytochemical constituents of extracts from leaves and fruits of&lt;em&gt; A. colubrina&lt;/em&gt;. &lt;strong&gt;Material and Methods:&lt;/strong&gt; Samples were collected in Catimbau National Park (Bu&amp;iacute;que, Pernambuco, Brazil) at September 2010 (RI: 75 mm) and January (RI: 65 mm), April (RI: 162 mm) and June 2011 (RI: 73 mm). The extracts were prepared by Soxhlet extraction using cyclohexane, chloroform, ethyl acetate and methanol. The antimicrobial activity was determined by MIC and MBC values. &lt;strong&gt;Results:&lt;/strong&gt; All extracts showed antimicrobial activity, but ethyl acetate extracts (from all periods) were more active. Strong correlations were found between the RI and the average MIC of MLE (&amp;rho;: -0.99), EALE (&amp;rho;: -0.81), CHFE (&amp;rho;: -0.81), EAFE (&amp;rho;: -0.80); while moderate and weak correlations were found for other extracts. Through a HPLC analysis was possible to reveal that the samples collected from dry periods had more chemical diversity (as they presented more peaks). Gallic acid and quercetin (and derivative compounds) were identified. The levels of quercetin were enhanced in extracts from dry months. &lt;strong&gt;Conclusion:&lt;/strong&gt; Our results showed that the rainfall has a positive effect on the antimicrobial activity of leaves and fruits of A. &lt;em&gt;colubrina&lt;/em&gt;, however these extracts showed more chemical diversity during dry months.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">435</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Daniel Rodrigo Cavalcante de Ara&amp;uacute;jo&lt;sup&gt;1&lt;/sup&gt;, Lu&amp;iacute;s Cl&amp;aacute;udio Nascimento da Silva&lt;sup&gt;2&lt;/sup&gt;, Wolfgang Harand&lt;sup&gt;3&lt;/sup&gt;, J&amp;uacute;lia Morais Fernandes&lt;sup&gt;4&lt;/sup&gt;, Thaciane da Cunha Soares&lt;sup&gt;4&lt;/sup&gt;, Silvana Maria Zucolotto Langassner&lt;sup&gt;4&lt;/sup&gt;, Raquel Brandt Giordani&lt;sup&gt;4&lt;/sup&gt;, Rafael Matos Ximenes&lt;sup&gt;5&lt;/sup&gt;, Alexandre Gomes da Silva&lt;sup&gt;1&lt;/sup&gt;, M&amp;aacute;rcia Vanusa da Silva&lt;sup&gt;1&lt;/sup&gt;, Maria Tereza dos Santos Correia&lt;sup&gt;1* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laborat&amp;oacute;rio de Produtos Naturais, Departamento de Bioqu&amp;iacute;mica, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Programa de Mestrado em Biologia Parasit&amp;aacute;ria, Universidade CEUMA, Maranh&amp;atilde;o, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laborat&amp;oacute;rio de Fitoqu&amp;iacute;mica, Instituto Nacional do Semi-&amp;Aacute;rido (INSA), Para&amp;iacute;ba, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Farm&amp;aacute;cia, Universidade Federal do Rio Grande do Norte, Rio Grande do Norte, BRASIL.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Laborat&amp;oacute;rio de Farmacognosia, Departamento de Antibi&amp;oacute;ticos, Universidade Federal de Pernambuco, Pernambuco, BRASIL.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yudi Her Oktaviono</style></author><author><style face="normal" font="default" size="100%">Alisia Yuana Putri</style></author><author><style face="normal" font="default" size="100%">Makhyan Jibril Al-Farabi</style></author><author><style face="normal" font="default" size="100%">Yesita Rizky Firmansyah</style></author><author><style face="normal" font="default" size="100%">Ferry Sandra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Extracellular-Signal Regulated Kinase Signalling Pathway Mediates the Increased Proliferation of EPCs Treated with Garlic (Allium sativum) Extract, Purple Sweet Potato (Ipomoea batatas) Extract and Vitamin C</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Endothelial Progenitor</style></keyword><keyword><style  face="normal" font="default" size="100%">ERK</style></keyword><keyword><style  face="normal" font="default" size="100%">Proliferation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">442-447</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The endothelial progenitor cell (EPCs) proliferation capability is reduced in the patient with stable coronary artery disease (SCAD). Garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), purple sweet potato (Ipomoea batatas), and vitamin C are proven antioxidant which potentially improve EPCs proliferation ability. &lt;strong&gt;Objective:&lt;/strong&gt; To investigate the effect of garlic (&lt;em&gt;Allium sativum&lt;/em&gt;), purple sweet potato (Ipomoea batatas), and vitamin C in EPCs proliferation from CAD patients and identify the involvement of Extracellular-Signal Regulated Kinase (ERK) Signalling Pathway. &lt;strong&gt;Material and Method:&lt;/strong&gt; Mononuclear cells were isolated from SCAD patients and cultivated with colony-forming unit (CFU)-Hill medium and divided into untreated (control), garlic extract (10 mcg/ml and 100 mcg/ml), purple sweet potato extract (1 mcg/ml and 25 μg/ml), and vitamin C (10 μg/ml and 250 μg/ml). EPCs proliferation was measured using the MTT Assay.&lt;strong&gt; Results: &lt;/strong&gt;This research shows that EPCs proliferation was increased in the treatment with garlic extract at 10 mcg/ml and 100 mcg/ml dose (0.267 ± 0,003 and 0.391 ± 0.008 ; p &amp;lt; 0.05), purple sweet potato extract at 1 mcg/ml and 25 μg/ml dose (0.250 ± 0.005 and 0.3562 ± 0.023 ; p &amp;lt; 0.001), and vitamin C at 10 μg/ml and 250 μg/ml dose (0.259 ± 0.016 and 0.306 ± 0.022 ; p &amp;lt; 0.001). Increased ERK expression was found in the treatment with garlic extract, purple sweet potato extract and vitamin C. &lt;strong&gt;Conclusion: &lt;/strong&gt;Garlic extract, purple sweet potato extract, and vitamin C can increase EPC proliferation through the ERK signaling pathway.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">442</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Yudi Her Oktaviono&lt;sup&gt;1,&lt;/sup&gt;*, Alisia Yuana Putri&lt;sup&gt;1&lt;/sup&gt;, Makhyan Jibril Al-Farabi&lt;sup&gt;1,2&lt;/sup&gt;, Yesita Rizky Firmansyah&lt;sup&gt;3&lt;/sup&gt;, Ferry Sandra&lt;sup&gt;4,5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Airlangga, Prof Moestopo Street 6-8, Surabaya, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Management, Healthcare Entrepreneurship Division, University College London, Gower St, Bloomsbury, WC1E 6BT London, UK.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Postgraduate School of Biomedicine, Faculty of Medicine, Brawijaya University, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Prodia Stem Cell Laboratory, Kramat 7 No. 11 Street, Jakarta, INDONESIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Dentistry, Universitas Trisakti, Kyai Tapa Street No.260, Jakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Eriawan Rismana</style></author><author><style face="normal" font="default" size="100%">Sri Ningsih</style></author><author><style face="normal" font="default" size="100%">Fachry Fachrudin</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Study of Xanthine Oxidase Inhibitory of Gambir (Uncaria gambir) Hunter Roxb Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">(+) Catechin.</style></keyword><keyword><style  face="normal" font="default" size="100%">Gambir (Uncaria gambir) Hunter Roxb</style></keyword><keyword><style  face="normal" font="default" size="100%">Inhibitory</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyphenol</style></keyword><keyword><style  face="normal" font="default" size="100%">Xanthine Oxidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/188</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">862-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Hyperuricemia was a metabolic disorder characterized by high levels of uric acid due to the action of the enzyme xanthine oxidase (XO). Some natural substances with antioxidant activity proved capable of inhibiting the activity of the enzyme XO. Pharmacological benefit of polyphenol compounds had been proved. Gambir (&lt;em&gt;Uncaria gambir&lt;/em&gt;) Hunter Roxb, a native plant, had been proved antioxidant activity, so that it had potential to be developed as an inhibitor of the XO. This study aimed to evaluate the activity of Gambir as XO inhibitor. &lt;strong&gt;Methods:&lt;/strong&gt; These extracts of Gambir were preparation from Gambir and Gambir leaf using ethanol 50% and ethanol 96%, respectively. The polyphenol content and Xanthine oxidase inhibitory activity was evaluated by spectrophotometry, meanwhile analysis of (+)catechin was determined by high pressure liquid chromatography (HPLC). &lt;strong&gt;Results:&lt;/strong&gt; Screening XO inhibitory activity &lt;em&gt;in vitro&lt;/em&gt; showed that ethanolic 96% extract of Gambir leaf showed the highest activity, i.e. 50% relative to standard allopurinol at the final concentration of 100 ppm. &lt;strong&gt;Conclusion:&lt;/strong&gt; There was no positive correlation between XO inhibitory activity and polyphenol or (+)catechin content.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">862</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Eriawan Rismana&lt;sup&gt;1*&lt;/sup&gt;, Sri Ningsih&lt;sup&gt;1&lt;/sup&gt;, Fachry Fachrudin&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Center for Pharmaceutical and Medical Technology, Agency for the Asessment and Application of Technology (BPPT), Laptiab Laboratory, 610-611 Building, Kawasan Puspiptek Serpong, Tangerang, Banten-INDONESIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, National Islamic University, Tangerang , Banten-INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Rawan El-Haj</style></author><author><style face="normal" font="default" size="100%">Dania Shoumar</style></author><author><style face="normal" font="default" size="100%">Rana Alaaeddine</style></author><author><style face="normal" font="default" size="100%">Yousra Fakhro</style></author><author><style face="normal" font="default" size="100%">Natalie Tawil</style></author><author><style face="normal" font="default" size="100%">Farah Shaer</style></author><author><style face="normal" font="default" size="100%">Amani Daher</style></author><author><style face="normal" font="default" size="100%">Natalie Awada</style></author><author><style face="normal" font="default" size="100%">Ali Sabra</style></author><author><style face="normal" font="default" size="100%">Khouloud Atwi</style></author><author><style face="normal" font="default" size="100%">Malak Khaled</style></author><author><style face="normal" font="default" size="100%">Raneem Messi</style></author><author><style face="normal" font="default" size="100%">Nour Abouzaher</style></author><author><style face="normal" font="default" size="100%">Mohamed Houri</style></author><author><style face="normal" font="default" size="100%">Samer Al Jallad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuropathic Pain: Literature Review and Recommendations of Potential Phytotherapies</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Current therapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Diagnosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Mechanisms</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuropathy Pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapies</style></keyword><keyword><style  face="normal" font="default" size="100%">Recommendations</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-4/10.5530pj.2017.4.72</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">425-434</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; One of the common syndromes that affect humanity is neuropathic pain (NP), yet poorly understood with no efficient treatment till now. Consequently, it is extremely crucial to seek further evidence for accurate diagnosis and optimum treatment. The aim of this work is to summarize the findings related to neuropathic pain in terms of etiology, types, diagnosis, current and future management prospective, and identify the gaps in neuropathic pain therapy. &lt;strong&gt;Methods:&lt;/strong&gt; A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of phytotherapies was based upon their potentials in relieving NP in pre-clinical or clinical models. &lt;strong&gt;Results:&lt;/strong&gt; One of the most critical points in this research is that recommendations of the future plans should be focused on the engagement of phytotherapy in the treatment regimen aiming at improving patients&amp;rsquo; quality of life and reaching optimum efficacy and minimum toxicity. Phytotherapies offer relatively low-risk options to NP patients and have an increasing evidence to be the future of neuropathic pain management. Patients suffering from neuropathy are depending increasingly on phytotherapies; however, they need more clinical trials in order to fully understand their mechanism of actions. &lt;strong&gt;Conclusion:&lt;/strong&gt; Health-care specialists should be regularly informed about neuropathic pain current therapies and promising future phytotherapies, bearing in mind the risk/benefit profile of the utilization of these therapies in the amelioration of NP.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">425</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Karim Raafat&lt;sup&gt;*&lt;/sup&gt;, Rawan El-Haj, Dania Shoumar, Rana Alaaeddine, Yousra Fakhro, Natalie Tawil, Farah Shaer, Amani Daher, Natalie Awada, Ali Sabra, Khouloud Atwi, Malak Khaled, Raneem Messi, Nour Abouzaher, Mohamed Houri and Samer Al Jallad &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, LEBANON,&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelsamed Ibrahim Elshamy</style></author><author><style face="normal" font="default" size="100%">Mohamed El-Shazly</style></author><author><style face="normal" font="default" size="100%">Yomna Mahmoud Yassine</style></author><author><style face="normal" font="default" size="100%">Mona Anwar El-Bana</style></author><author><style face="normal" font="default" size="100%">Abdel- Razik Farrag</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ibrahim Nassar</style></author><author><style face="normal" font="default" size="100%">Abdel Nasser Singab</style></author><author><style face="normal" font="default" size="100%">Masaaki Noji</style></author><author><style face="normal" font="default" size="100%">Akemi Umeyama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic Constituents, Anti-Inflammatory and Antidiabetic Activities of Cyperus laevigatus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyperus Laevigatus</style></keyword><keyword><style  face="normal" font="default" size="100%">New Flavone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/182</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">828-833</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cyperus&lt;/em&gt; species are well known traditional plants and used for several diseases around the world. &lt;strong&gt;Aim of the Study:&lt;/strong&gt; Our study aimed to identification of the phenolic constituents in addition to evaluation of different extracts of &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L as antioxidant, antiinflammatory and antidiabetic agents. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phenolic constituents were identified using spectroscopic techniques. The antioxidant activity was evaluated using &lt;em&gt;in vitro&lt;/em&gt; DPPH assay. Total extract, methanol and EtOAc fractions were evaluated for their antiinflammatory activity using RAW 264.7 macrophages assay. Antidiabetic activity of the total extract was examined biochemically and histopathologically using streptozotocin-induced diabetic rats. &lt;strong&gt;Results:&lt;/strong&gt; A new flavone, chrysoeriol 7-&lt;em&gt;O&lt;/em&gt;-&amp;beta;-(6‴-&lt;em&gt;O-acetyl&lt;/em&gt;-&amp;beta;-D-glucopyranosyl)-(1&amp;rarr;4) glucopyranoside (1), along with seven knowns (2-8) were isolated from &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L. The structures of isolated compounds were established depending upon 1D, 2D-NMR and HR-ESI-MS. The MeOH and EtOAc fractions exhibited significant antioxidant activity while the isolated flavonoids exhibited from moderate to weak antioxidant activity. The total extract, MeOH and EtOAc fractions exhibited significant anti-inflammatory activity using LPS-stimulated RAW 264.7 macrophages model by decreasing of NO accumulation by 76 &amp;ndash; 66% and 84 &amp;ndash; 67%, of the original accumulation values with increasing concentrations in comparison with the reference drug, dexamethasone. The total extract exhibited antidiabetic activity in streptozotocin-induced diabetic rats and this effect was manifested by decreasing serum levels of glucose, glucagon and NO. It also increased level of insulin and promoted paraoxonase activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results proved that this plant may be multiple sources for medicinal natural drugs especially for anti-inflammatory and antidiabetic.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Abdelsamed Ibrahim Elshamy&lt;sup&gt;1,5*&lt;/sup&gt;, Mohamed El- Shazly&lt;sup&gt;2&lt;/sup&gt;, Yomna Mahmoud Yassine&lt;sup&gt;1&lt;/sup&gt;, Mona Anwar El- Bana&lt;sup&gt;3&lt;/sup&gt;, Abdel-Razik Farrag&lt;sup&gt;4&lt;/sup&gt;, Mahmoud Ibrahim Nassar&lt;sup&gt;1&lt;/sup&gt;, Abdel Nasser Singab&lt;sup&gt;2&lt;/sup&gt;, Masaaki Noji&lt;sup&gt;5&lt;/sup&gt;, Akemi Umeyama&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Biochemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, JAPAN.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amna Parveen</style></author><author><style face="normal" font="default" size="100%">Zahra</style></author><author><style face="normal" font="default" size="100%">Muhammad Qudratullah Farooqi</style></author><author><style face="normal" font="default" size="100%">Whang Wan Kyunn</style></author><author><style face="normal" font="default" size="100%">Muhammad Arshad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Screening and Content Determination of Different Species of Genus Caesalpinia belonging to Different Origin with Antidiabetic Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidants</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC Fingerprint</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical content.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/170</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">743-749</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The main aim of the study is to investigate the phytochemical screening of &lt;em&gt;C. decapetala&lt;/em&gt; along with the content determination of different species of genus &lt;em&gt;Caesalpinia&lt;/em&gt; with respect to their antidiabetic activity and identification of most bioactive species belonging to different origins. &lt;strong&gt;Methods:&lt;/strong&gt; To achieve our goal different species of genus &lt;em&gt;Caesalpinia&lt;/em&gt; collected from China and Pakistan were subjected to open column chromatography, High Pressure Liquid Chromatography (HPLC), antioxidant, and antidiabetic assays for evaluation. &lt;strong&gt;Results:&lt;/strong&gt; From &amp;eta;-BuOH fraction of &lt;em&gt;C. decapetala&lt;/em&gt; extract, eight compounds were isolated using open column chromatography and identified as apigenin-7-rhamnoside (1), 4-O-methylepisappanol (2), caesalpinol (3), daucosterol (4), astragalin (5), kaempferol (6), quercitrin (7), and naringin (8) using Nuclear Magnetic Resonance (NMR) spectroscopy. HPLC analysis of different species of genus &lt;em&gt;Caesalpinia&lt;/em&gt; showed that the most active antidiabetic compound &amp;lsquo;quercitrin&amp;rsquo; was present more in &lt;em&gt;C. pulcherrima&lt;/em&gt; followed by decreasing order in &lt;em&gt;C. sappan, C.decapetala,&lt;/em&gt; and &lt;em&gt;C. bonduc.&lt;/em&gt; &lt;strong&gt;Conclusion:&lt;/strong&gt; The results indicated that quercitrin is the most bioactive content and &lt;em&gt;C. pulcherrima&lt;/em&gt; is most bioactive specie of China origin from genus &lt;em&gt;Caesalpinia&lt;/em&gt;.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">743</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Amna Parveen&lt;sup&gt;1,2,3,*&lt;/sup&gt;, Zahra&lt;sup&gt;4&lt;/sup&gt;, Muhammad Qudratullah Farooqi&lt;sup&gt;5&lt;/sup&gt;, Whang Wan Kyunn&lt;sup&gt;2&lt;/sup&gt;, Muhammad Arshad&lt;sup&gt;4&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;College of Pharmacy, Gachon University, No. 191, Hambakmoero, Yeonsu-gu, Incheon 406-799, REPUBLIC OF KOREA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&amp;nbsp;&lt;/sup&gt;Pharmaceutical Resources Botany Laboratory, Department of Pharmacognosy, College of Pharmacy, Chung-Ang University, Room No:416, bldg.: 102, 221, Heukseok-dong, Dongjak gu, Seoul 156-756, REPUBLIC OF KOREA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, College of Pharmacy, Government College University Faisalabad, Faisalabad, PAKISTAN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Institute of Environmental Sciences and Engineering, School of Civil and Environmental Engineering, National University of Sciences and Technology, Sector H-12, Islamabad 44000, PAKISTAN.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Applied Plant Sciences, College of Agriculture and Life Sciences, Kangwon National University, Chuncheon 24341, REPUBLIC OF KOREA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alejandra Fernandez</style></author><author><style face="normal" font="default" size="100%">Ian Edwin Cock</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Therapeutic Properties of Juniperus Communis L.: Antioxidant Capacity, Bacterial growth Inhibition, Anticancer Activity and Toxicity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-bacterial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant.</style></keyword><keyword><style  face="normal" font="default" size="100%">Artemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Autoimmune inflammatory disease</style></keyword><keyword><style  face="normal" font="default" size="100%">CaCo2</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa</style></keyword><keyword><style  face="normal" font="default" size="100%">Juniper berry</style></keyword><keyword><style  face="normal" font="default" size="100%">Traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan/2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">273-280</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;J. Communi s&lt;/em&gt;berry is a high antioxidant fruit which is used in several traditional medicinal systems to treat a variety of diseases including rheumatism, arthritis and gout&lt;em&gt;.&lt;/em&gt;This study was undertaken to examine the inhibitory activity of &lt;em&gt;J. communis&lt;/em&gt; berry extracts on the growth of several bacteria associated with autoimmune inflammatory disease, and to test their ability to block CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cancer cell proliferation. &lt;strong&gt;Methods: &lt;/strong&gt;&lt;em&gt;J. Communis &lt;/em&gt;solvent extracts were preparedusing solvents of varying polarity. The extracts were investigated by disc diffusion assay for the ability to inhibit the growth of a panel of pathogenic bacteria associated with autoimmune inflammatory diseases. Their MIC values were determined to quantify and compare their efficacies. Inhibitory activity against CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa human carcinoma cell lines was evaluated using an MTS colorimetric cell proliferation assay. Toxicity was determined using the &lt;em&gt;Artemia franciscana&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Results: &lt;/strong&gt;The methanol, water and ethyl acetate &lt;em&gt;J. communis&lt;/em&gt; berry extracts displayed moderate to potent growth inhibitory activity against bacterial triggers of rheumatoid arthritis, ankylosing spondylitis and multiple sclerosis. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all bacteria tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 9 of the 13 bacterial strains (69%). The ethyl acetate extract displayed the greatest potency, with MIC values substantially below 2000 &amp;micro;g/mL for all bacteria which it inhibited. It was most effective at inhibiting the growth of &lt;em&gt;P. mirabilis&lt;/em&gt;, &lt;em&gt;P. vulgaris&lt;/em&gt; and &lt;em&gt;S. aureus&lt;/em&gt;, each with MIC&amp;rsquo;s &amp;le; 500 &amp;micro;g/mL. The methanol and water extracts also proved effective at blocking the proliferation of the colorectal cancer cell line CaCo&lt;sub&gt;2&lt;/sub&gt; and HeLa cervical cancer cell growth, with IC&lt;sub&gt;50&lt;/sub&gt; values in the 1300-2500 &amp;micro;g/mL range. All extracts were non-toxic in the &lt;em&gt;Artemia&lt;/em&gt; nauplii bioassay. &lt;strong&gt;Conclusion: &lt;/strong&gt;The lack of toxicity of the &lt;em&gt;J. Communis &lt;/em&gt;berry extracts and their potent growth inhibitory bioactivity against bacteria and HeLa and CaCo&lt;sub&gt;2&lt;/sub&gt; carcinoma cells indicates their potential in the treatment and prevention of selected autoimmune inflammatory diseases and some cancers.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Orginal Article</style></work-type><section><style face="normal" font="default" size="100%">273</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Alejandra Fernandez&lt;sup&gt;1&lt;/sup&gt; and Ian Edwin Cock&lt;sup&gt;1,2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Queensland 4111, AUSTRALIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Faheem</style></author><author><style face="normal" font="default" size="100%">Mohd Suhail</style></author><author><style face="normal" font="default" size="100%">Kaneez Fatima</style></author><author><style face="normal" font="default" size="100%">Govindaraju Archunan</style></author><author><style face="normal" font="default" size="100%">Nargis Begum</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas</style></author><author><style face="normal" font="default" size="100%">Esam Azhar</style></author><author><style face="normal" font="default" size="100%">Ghazi Abdullah Damanhouri</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Updates on Traditional Medicinal Plants for Hepatocellular Carcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmaceutical Journals</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbs</style></keyword><keyword><style  face="normal" font="default" size="100%">Liver cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicine</style></keyword><keyword><style  face="normal" font="default" size="100%">Treatment.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">203-214</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim: &lt;/strong&gt;Hepatocellular carcinoma (HCC) is a major worldwide problem primarily caused by hepatitis B and C virus infection. End stage liver cancer treatment options are limited thus requiring expensive liver transplantation which is not available in many countries. &lt;strong&gt;Methods: &lt;/strong&gt;Several herbal compounds and herbal composite formulas have been studied through &lt;em&gt;in-vitro &lt;/em&gt;and &lt;em&gt;in vivo &lt;/em&gt;as an anti-HCC agent, enhancing our knowledge about their biological functions and targets. In this article, arecent update on the herbal medicine has been provided with reference to liver cancer. &lt;strong&gt;Results:&lt;/strong&gt; For the sake of clarity, the effective herbal compounds, clinical studies of herbal composite formula, cell culture, and animal model studies safety are discussed. The effects of many herbal active compounds of &lt;em&gt;Annona atemoya,&lt;/em&gt; &lt;em&gt;Andrographis paniculata, Boerhaviadiffusa,&lt;/em&gt; &lt;em&gt;Piper longum, Podophyllum&lt;/em&gt; &lt;em&gt;hexandrum, Phyllanthus amarus, &lt;/em&gt;and &lt;em&gt;Terminalia chebula&lt;/em&gt;, and herbal composite formula on autophagy, apoptosis, antioxidant, and inflammation characteristicshave been provided. &lt;strong&gt;Conclusion: &lt;/strong&gt;This will enhance our understanding&amp;nbsp;on the prevention and treatment of HCC by herbal active compounds&amp;nbsp;and herbal composite formulas.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">203</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shilu Mathew&lt;sup&gt;1,2,3&lt;/sup&gt;, Muhammad Faheem&lt;sup&gt;4&lt;/sup&gt;, Mohd Suhail&lt;sup&gt;5&lt;/sup&gt;, Kaneez Fatima&lt;sup&gt;6&lt;/sup&gt;, Govindaraju Archunan&lt;sup&gt;3&lt;/sup&gt;, Nargis Begum&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas&lt;sup&gt;7&lt;/sup&gt;, Esam Azhar&lt;sup&gt;5&lt;/sup&gt;, Ghazi Abdullah Damanhouri&lt;sup&gt;5&lt;/sup&gt; and Ishtiaq Qadri&lt;sup&gt;5&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Postgraduate Department of Biotechnology, Jamal Mohamed College, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Animal Science, Bharathidasan University, Tiruchirappalli, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biosciences, Faculty of Sciences, COMSATS Institute of Information Technology, Islamabad, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Biotechnology and Translational Medicine Research, King Fahd Medical Research Center, King Abdul Aziz University, PO Box 80216, SAUDI ARABIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;IQ Institute of Infection and Immunity, Lahore, PAKISTAN.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Department of Botany, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Boga Gogo Lucien</style></author><author><style face="normal" font="default" size="100%">Bahi Calixte</style></author><author><style face="normal" font="default" size="100%">Yapi Houphouët Félix</style></author><author><style face="normal" font="default" size="100%">N’Guessan Jean David</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Konkon N’Dri Gilles</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Djaman Allico Joseph</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Acute and Subacute Toxicity of the Total Dichloromethane-Ethanol Extract of Morinda morindoides (Baker) Milne-Redh (ETDE) on Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Damage</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda morindoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight gain.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; ETDE shown good antihypertensive and antioxidant activities in rats made hypertensive. This present study aims to assess its toxicity. &lt;strong&gt;Aims:&lt;/strong&gt; This study was designed to study the toxicity of dichloromethaneethanol extract of Morinda morindoides. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Toxicological activity in vivo. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Alkaloids were characterized from reagents of Bouchardat, flavonoids by reacting the cyanidrine, tannins by the reagent Stiasny, polyphenols by reacting ferric chloride, quinones by the reagent Bornstra&amp;euml;gen, sterols and polyterpenes by the reaction of Libermann and saponins by observing the foam after agitation of the extract. Acute and subacute toxicity were studied using respectively 423 and 407 OECD guidelines for testing of chemicals. Statistical analysis used: The graphical representation of the data was performed using the Graph Pad Prism 5.0. The mean value is accompanied by the standard error of the mean (Mean &amp;plusmn; SEM). The difference between the two values is considered significant when P&amp;lt;0.001. Statistical analysis of results was performed using analysis of variance (ANOVA). &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening showed the presence in the ETDE of polyphenols, alkaloids, flavonoids, sterols and polyterpenes. The toxicological study shows that ETDE has a LD50 between 2000 and 5000 mg/kg bw therefore classified in the hazard category 5. The administration of ETDE at repeated dose for 28 days did not significantly affect the weight gain, hematological and biochemical parameters of rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; ETDE toxicity is relatively low with LD50 between 2000 and 5000 mg/kg bw. It does not cause damage to the heart, liver and kidney. ETDE can be used without risk of intoxication.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Boga Gogo Lucien&lt;sup&gt;*1&lt;/sup&gt;, Bahi Calixte&lt;sup&gt;1&lt;/sup&gt;, Konkon N&amp;rsquo;Dri Gilles&lt;sup&gt;2&lt;/sup&gt;, Yapi Houphou&amp;euml;t F&amp;eacute;lix&lt;sup&gt;1&lt;/sup&gt;, Djaman Allico Joseph&lt;sup&gt;1,3&lt;/sup&gt; and N&amp;rsquo;Guessan Jean David&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Biosciences, Biochemical Pharmacodynamy Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. &lt;sup&gt;2&lt;/sup&gt;Department of Biosciences, Botanical Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. 3Department of Clinical and Basic Biochemistry, Pasteur Institute of C&amp;ocirc;te d&amp;rsquo;Ivoire, Abidjan 04, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dandare Shamsudeen Umar</style></author><author><style face="normal" font="default" size="100%">Bawa Muhammad</style></author><author><style face="normal" font="default" size="100%">Wasagu Ibrahim Zubairu</style></author><author><style face="normal" font="default" size="100%">Magaji Umar Faruk</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective effect of Quail egg against carbon tetra chloride (CCl4) induced hepatic damage in albino rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar-Apr 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">102-106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Quail egg has been used traditionally in the treatment of many ailments. Despite the wide speculations of its involvement in the treatment of liver diseases, very little scientific evidence exist to support this claim. This work investigated the hepatoprotective effect of quail egg against carbon tetrachloride (CCl4) induced liver damage in albino rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The rats were divided into five groups of five rats per group. Animals of group A (positive control) were fed with vehicle (distilled water) on the first four days and with vehicle and CCl4 on the fifth, sixth and seventh day. Animals of group B (negative control) were given only vehicle for seven days. Animals of groups C, D and E were respectively administered with 100, 200 and 400 mg/kg body weight of quail egg for the first four days and with vehicle, quail egg and CCl4 for the fifth, sixth and seventh day. Animals were subsequently anaesthetized, and blood samples were taken for the estimation of albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein (TP) and bilirubin. The liver was isolated for histopathological studies. &lt;strong&gt;Results:&lt;/strong&gt; The levels of ALT, ALP and TP were significantly affected (p &amp;lt; 0.05) in CCl4 fed groups, indicating liver injury. The effects were reduced significantly (p &amp;lt; 0.05) after treatment of rats with quail egg. Furthermore, histopathological studies of the liver tissues also supported the hepatoprotective activity of quail egg- photomicrographs of treated groups showed mild reduction in vacuolarisation/ballooning degeneration of the hepatocytes. &lt;strong&gt;Conclusion:&lt;/strong&gt; Quail egg showed some potentials of protecting the liver from damage by stabilising the levels of ALP, ALT and TP and reducing the degeneration of the hepatocytes. Thus, this finding has provided information that suggests utilising quail egg for treatment of liver dysfunction.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Dandare Shamsudeen Umar&lt;sup&gt;1*,&lt;/sup&gt; Bawa Muhammad&lt;sup&gt;1&lt;/sup&gt;, Wasagu Ibrahim Zubairu&lt;sup&gt;2&lt;/sup&gt; and Magaji Umar Faruk&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Science,&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Department of Chemical Pathology, Faculty of Medical Laboratory Science,&lt;br /&gt;
Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dandare Shamsudeen Umar</style></author><author><style face="normal" font="default" size="100%">Bawa Muhammad</style></author><author><style face="normal" font="default" size="100%">Wasagu Ibrahim Zubairu</style></author><author><style face="normal" font="default" size="100%">Magaji Umar Faruk</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Quail Egg Against Carbontetrachloride (CCl4) Induced Hepatic Damage in Albino Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotection</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology.</style></keyword><keyword><style  face="normal" font="default" size="100%">Quail egg</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Dec, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">102-106</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Quail egg has been used traditionally in the treatment of many ailments. Despite the wide speculations of its involvement in the treatment of liver diseases, very little scientific evidence exist to support this claim. This work investigated the hepatoprotective effect of quail egg against carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;) induced liver damage in albino rats.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The rats were divided into five groups of five rats per group. Animals of group A (positive control) were fed with vehicle (distilled water) on the first four days and with vehicle and CCl4 on the fifth, sixth and seventh day. Animals of group B (negative control) were given only vehicle for seven days. Animals of groups C, D and E were respectively administered with 100, 200 and 400 mg/kg body weight of quail egg for the first four days and with vehicle, quail egg and CCl&lt;sub&gt;4&lt;/sub&gt; for the fifth, sixth and seventh day. Animals were subsequently anaesthetized, and blood samples were taken for the estimation of albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total protein (TP) and bilirubin. The liver was isolated for histopathological studies. &lt;strong&gt;Results: &lt;/strong&gt;The levels of ALT, ALP and TP were significantly affected (p &amp;lt; 0.05) in CCl&lt;sub&gt;4&lt;/sub&gt; fed groups, indicating liver injury. The effects were reduced significantly (p &amp;lt; 0.05) after treatment of rats with quail egg. Furthermore, histopathological studies of the liver tissues also supported the hepatoprotective activity of quail egg- photomicrographs of treated groups showed mild reduction in vacuolarisation/ballooning degeneration of the hepatocytes. &lt;strong&gt;Conclusion: &lt;/strong&gt;Quail egg showed some potentials of protecting the liver from damage by stabilising the levels of ALP, ALT and TP and reducing the degeneration of the hepatocytes. Thus, this finding has provided information that suggests utilising quail egg for treatment of liver dysfunction.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key Words: &lt;/strong&gt;Quail egg, Carbon tetrachloride, Hepatotoxicity, Hepatoprotection, Histopathology.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">102</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Dandare Shamsudeen Umar&lt;sup&gt;1*&lt;/sup&gt;, Bawa Muhammad&lt;sup&gt;1&lt;/sup&gt;, Wasagu Ibrahim Zubairu&lt;sup&gt;2&lt;/sup&gt; and Magaji Umar Faruk&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Science,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical Pathology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, P.M.B. 2346, Sokoto, Nigeria.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haroon Khan</style></author><author><style face="normal" font="default" size="100%">Murad Ali Khan</style></author><author><style face="normal" font="default" size="100%">Abdul Rauf</style></author><author><style face="normal" font="default" size="100%">Ashhad Haleemi</style></author><author><style face="normal" font="default" size="100%">Shivkanya Fuloria</style></author><author><style face="normal" font="default" size="100%">Neeraj Kumar Fuloria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition on Urease and Thermal Induced Protein Denaturation of commonly used Antiulcer Herbal Products. Study based on in-vitro assays</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Akseer ULCER</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiurease activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Endemali</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal induced protein denaturation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">16th Jan, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">147-151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;In-vitro&lt;/em&gt; urease inhibitory and thermal induced protein denaturation inhibitory activitieswasperformed for two commonly used herbal productsEndemali and Akseer ULCER in the treatment of ulcers.&lt;strong&gt;Objectives: &lt;/strong&gt;to evaluate the antiulcer potential of two commonly used herbal products, Endemali, Akseer ULCER. &lt;strong&gt;Material and Method:&lt;/strong&gt; In urease inhibitory assay , enzyme solution, extract, diferentregaents added and absorbance was measured at 630 nm (50 min, pH 8.2) and thiourea used as standard. In protein denaturation assay the egg albumin was mixed with different concentration of test compounds, buffer absorbance was measured. Aspirin was used as standard. &lt;strong&gt;Results:&lt;/strong&gt; The Endemalihad a profound effect on the urease activity in a concentration dependent manner with EC&lt;sub&gt;50&lt;/sub&gt; valueof 0.468 mg/ml. The Akseer ULCER antagonized the urease activity markedly with EC&lt;sub&gt;50 &lt;/sub&gt;value of 0.374 mg/ml.These tested herbal products caused marked inhibition of thermal induced protein denaturation in a concentration dependent manner. The potency in the form of EC&lt;sub&gt;50 &lt;/sub&gt;for Endemali, Akseer ULCER was measured as 323, 337 &amp;micro;g/mlrespectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; In short, the tested herbal drug showed strong inhibition on urease activity and inhibition on thermal induced protein denaturation thus our study validated their uses in the treatment of ulcers.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Akseer ULCER, Endemali, Antiurease activity, Thermal induced protein denaturation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">147</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Haroon Khan&lt;sup&gt;*1&lt;/sup&gt;, Murad Ali Khan&lt;sup&gt;2&lt;/sup&gt;, Abdul Rauf&lt;sup&gt;3&lt;/sup&gt;, Ashhad Haleemi&lt;sup&gt;4&lt;/sup&gt;, Shivkanya Fuloria&lt;sup&gt;5&lt;/sup&gt;, Neeraj Kumar Fuloria&lt;sup&gt;5 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Chemical Sciences, University of Peshawar, Peshawar -25120, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, University of Peshawar, Peshawar -25120, Pakistan&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmcy, AIMST University,Semeling Campus, Bedong, Kedah Darul Aman-08100, Malyasia&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Haroon Khan</style></author><author><style face="normal" font="default" size="100%">Murad Ali Khan</style></author><author><style face="normal" font="default" size="100%">Abdul Rauf</style></author><author><style face="normal" font="default" size="100%">Ashhad Haleemi</style></author><author><style face="normal" font="default" size="100%">Shivkanya Fuloria</style></author><author><style face="normal" font="default" size="100%">Neeraj Kumar Fuloria</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibition on Urease and Thermal Induced Protein Denaturation of commonly used Antiulcer Herbal Products. Study based on in-vitro assays</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Akseer ULCER</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiurease activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Endemali</style></keyword><keyword><style  face="normal" font="default" size="100%">in-vitro assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Thermal induced protein denaturation.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">147-151</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;In-vitro&lt;/em&gt; urease inhibitory and thermal induced protein denaturation inhibitory activities was performed for two commonly used herbal products Endemali and Akseer ULCER in the treatment of ulcers. &lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the antiulcer potential of two commonly used herbal products, Endemali, Akseer ULCER. &lt;strong&gt;Material and Method:&lt;/strong&gt; In urease inhibitory assay, enzyme solution, extract, diferent regaents added and absorbance was measured at 630 nm (50 min, pH 8.2) and thiourea used as standard. In protein denaturation assay, the egg albumin was mixed with different concentration of test compounds, buffer absorbance was measured. Aspirin was used as standard. &lt;strong&gt;Results:&lt;/strong&gt; The Endemali had a profound effect on the urease activity in a concentration dependent manner with EC50value of 0.468 mg/ml. The Akseer ULCER antagonized the urease activity markedly with EC&lt;sub&gt;50&lt;/sub&gt; value of 0.374 mg/ml. These tested herbal products caused marked inhibition of thermal induced protein denaturation in a concentration dependent manner. The potency in the form of EC&lt;sub&gt;50&lt;/sub&gt; for Endemali, Akseer ULCER was measured as 323, 337 &amp;mu;g/ml respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; In short, the tested herbal drug showed strong inhibition on urease activity and inhibition on thermal induced protein denaturation thus our study validated their uses in the treatment of ulcers.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">147</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Haroon Khan&lt;sup&gt;*1&lt;/sup&gt;, Murad Ali Khan&lt;sup&gt;2&lt;/sup&gt;, Abdul Rauf&lt;sup&gt;3&lt;/sup&gt;, Ashhad Haleemi&lt;sup&gt;4&lt;/sup&gt;, Shivkanya Fuloria&lt;sup&gt;5&lt;/sup&gt;, Neeraj Kumar Fuloria&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy, University of Peshawar, Peshawar-25120, Pakistan.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmcy, AIMST University,Semeling Campus, Bedong, Kedah Darul Aman-08100, Malyasia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shazia Usmani</style></author><author><style face="normal" font="default" size="100%">Arshad Hussain</style></author><author><style face="normal" font="default" size="100%">A.H.A Farooqui</style></author><author><style face="normal" font="default" size="100%">Mohd.Arshad</style></author><author><style face="normal" font="default" size="100%">Sahabjada Siddiqui</style></author><author><style face="normal" font="default" size="100%">Mohd.Ahmad</style></author><author><style face="normal" font="default" size="100%">Shadma Wahab</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Antiproliferative activity of crude extract and fractions obtained from Digera muricata on Hela cell lines of human cervix and A549 cell lines of Human Lung.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">3-(4</style></keyword><keyword><style  face="normal" font="default" size="100%">4 diphenyltetrazolium bromide assay</style></keyword><keyword><style  face="normal" font="default" size="100%">5-dimethylthiazol-2yl)-2</style></keyword><keyword><style  face="normal" font="default" size="100%">A549 Cell Line</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxic</style></keyword><keyword><style  face="normal" font="default" size="100%">Digera muricata</style></keyword><keyword><style  face="normal" font="default" size="100%">HeLa cell line</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">32-38</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;em&gt;Digera muricata&lt;/em&gt; (Linn.) of family Amaranthaceae is an ethanobotanically important plant species traditionally used against various disorders. Cytotoxic potential of methanolic extract and its fractions were investigated against Hela and A&lt;sub&gt;549&lt;/sub&gt; cell lines. Crude extract of Digera muricata was prepared in methanol by Continuous Hot Soxhlation technique. Crude extract was fractionated into two organic and one aqueous fraction by the help of Column Chromatography. MTT assay was used to evaluate the reduction of viability of the cancer cell lines. Cell viability was inhibited by crude extract of &lt;em&gt;Digera muricata&lt;/em&gt; in a dose dependent manner ranging from 25&amp;mu;g/ml to 250&amp;mu;g/ml. Apoptosis assays using nucleic acid stains namely PI exclusion assay and Hoestch/PI assay were performed by the help of fluorescence microscopy. Morphological analysis was done by calculation of Apoptotic ratio and Percentage apoptosis. Our results suggests that methanolic and aqueous fraction of the extract of &lt;em&gt;Digera muricata&lt;/em&gt; can be good source of cytotoxic compounds.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; 3-(4,5-dimethylthiazol-2yl)-2,4 diphenyltetrazolium bromide assay, A&lt;sub&gt;549&lt;/sub&gt; cell line, cytotoxic,
Digera muricata, HeLa cell line.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">32</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Shazia Usmani&lt;sup&gt;a*&lt;/sup&gt;&lt;sub&gt;, &lt;/sub&gt;Arshad Hussain&lt;sup&gt;a&lt;/sup&gt;, A.H.A Farooqui&lt;sup&gt;b&lt;/sup&gt;, Mohd.Arshad&lt;sup&gt;c&lt;/sup&gt;, Sahabjada Siddiqui&lt;sup&gt;c&lt;/sup&gt;, Mohd.Ahmad&lt;sup&gt;a&lt;/sup&gt;, Shadma Wahab&lt;sup&gt;a&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;a&lt;/sup&gt;Faculty of Pharmacy, Integral University, Kursi Road, Lucknow-226026, INDIA.&lt;/p&gt;&lt;p&gt;&lt;sup&gt;b&lt;/sup&gt;Faculty of Biosciences, Integral University, Kursi Road, Lucknow-226026, INDIA.&lt;/p&gt;&lt;p&gt;&lt;sup&gt;c&lt;/sup&gt;Department of Zoology, Faculty of Life Sciences, Lucknow University, Lucknow, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Makboul A. Makboul</style></author><author><style face="normal" font="default" size="100%">Ahmed A. Attia</style></author><author><style face="normal" font="default" size="100%">Salwa F. Farag</style></author><author><style face="normal" font="default" size="100%">Nesma M. Mohamed</style></author><author><style face="normal" font="default" size="100%">Samir A. Ross</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical constituents with free-radical-scavenging activity from the leaves of Lantana montevidensis (Spreng.) Briq.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoids free radical scavenging activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Lantana montevidensis.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">3rd Sept, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">27-31</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Seventy percent aqueous methanolic extract of the leaves of &lt;em&gt;Lantana montevidensis&lt;/em&gt; exhibited antibacterial, anti-inflammatory, anti-pyretic, antioxidant and analgesic activities. Previous phytochemical study of the leaves led to the isolation of various flavones, pentacyclic triterpenoids, &amp;beta;-sitosterol and benzoic acid. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The 70% aqueous methanolic extract of &lt;em&gt;L. montevidensis&lt;/em&gt; (Spreng.) Briq. leaves was partitioned between water and n-hexane, CHCl&lt;sub&gt;3&lt;/sub&gt;, EtOAc, and n-BuOH, successively. By using a series of different chromatographic techniques, the CHCl&lt;sub&gt;3&lt;/sub&gt; and EtOAc extracts afforded nine compounds. The isolated compounds were identified by spectroscopic techniques and by comparison with literature values and/or authentic samples. The free radical scavenging activity of some of the isolated compounds was evaluated. &lt;strong&gt;Results:&lt;/strong&gt; Hispidulin-7-O-glucurnoide methyl ester (1), hispidulin-7-O-glucoside (2), cinaroside (3), nepetin-7-O-glucoside (4) pectolinarigenin (5), apigenin (6), luteolin (7) in addition to salicylic acid (8) and &amp;beta;-sitosterol-3-O-glucoside (9) have been isolated. Compounds 1-4 are first report from the genus Lantana while compounds 5, 8 and 9 are first report from this plant. The structures of these compounds were elucidated on the basis of spectral methods, including 2D NMR experiments, and confirmed by comparing with the literature data and/or authentic samples. Additionally, some of the isolated flavonoids exhibited free radical scavenging activity. &lt;strong&gt;Conclusion:&lt;/strong&gt;&lt;em&gt;Lantana montevidensis&lt;/em&gt; (Spreng.) Briq. cultivated in Egypt is rich in biologically active ingredients.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&amp;nbsp; Apigenin, cinaroside, free radical scavenging activity, hispidulin-7-O-glucurnoide methyl ester, hispidulin-7-O-glucoside, &lt;em&gt;Lantana montevidensis&lt;/em&gt;, luteolin, nepetin-7-O-glucoside, pectolinarigenin.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">27</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Makboul A. Makboul&lt;sup&gt;1&lt;/sup&gt;, Ahmed A. Attia&lt;sup&gt;1&lt;/sup&gt;, Salwa Farouk Farag&lt;sup&gt;1*&lt;/sup&gt;, Nesma M. Mohamed&lt;sup&gt;1&lt;/sup&gt;, Samir A. Ross&lt;sup&gt;2,3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;National Center for Natural Products Research,&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, Mississippi, USA&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">A. Babalola Kadiri,</style></author><author><style face="normal" font="default" size="100%">O. Mawoussi Agboola,</style></author><author><style face="normal" font="default" size="100%">F. Olatunde. Fashina.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ethnobotanical survey and phyto-anatomical studies of some common plants used for the treatment of epilepsy in some rural areas of South west Nigeria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Epilepsy</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Plant anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">south-west Nigeria</style></keyword><keyword><style  face="normal" font="default" size="100%">tropical forestv</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">18th Feb,2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">96-102</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; To survey some areas in the southwest Nigeria where epilepsy is treated with plant extracts and determine the commonest plant species that are used, for pharmacognostic analysis. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Open-ended and semi-structured interviews were conducted for information from traditional medicine practitioners. Plant names given were authenticated in the herbarium and phytochemical and anatomical analyses were conducted on the plant parts that are used for treatment using standard approaches.&lt;strong&gt; Results:&lt;/strong&gt; Fifty practitioners were interviewed and they gave 17 different plants; out of these, the 5 commonest ones were investigated. The plants are either used individually or in combination with other plant(s). Services may be rendered freely or by collecting a token which is supernaturally believed to have negative consequences. The practitioners engaged in out-patient and in-patient services and patients are usually totally cured. There are also some inexplicable practices such as oracle visitation, incantations etc. A total of 30 patients have been cured in the last decade by each practitioner. Saponin, steroids, tannins, flavonoids, phlobatannins and alkaloids were isolated using three different media (methanol, petroleum ether and water) and diagnostic anatomical characters of the leaf epidermis, fruit wall, bark and root of the plants are presented in a single account for the first time in the country. The plants studied were &lt;em&gt;Newbouldia laevis&lt;/em&gt;, &lt;em&gt;Securidaca longipedunculata&lt;/em&gt;, &lt;em&gt;Tetrapleura tetraptera&lt;/em&gt;, &lt;em&gt;Nicotiana tabacum&lt;/em&gt; and &lt;em&gt;Senna occidentalis&lt;/em&gt;.&lt;strong&gt; Conclusion:&lt;/strong&gt; The phytochemicals found are suggestive of the underlying medicinal potency of the plants and future work will help to establish the most active principles which will lead to development of drugs for treating the disease. The diagnostic anatomical characters can be employed in resolving doubts especially when the plant materials are in fragments. The least mentioned plant species can be saved from harvesting to conserve the rich flora diversity in the country.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Epilepsy, phytochemistry, plant anatomy, south-west Nigeria, tropical forest.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">96</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;A. Babalola Kadiri&lt;sup&gt;a&lt;/sup&gt;, O. Mawoussi Agboola&lt;sup&gt;a&lt;/sup&gt; and F. Olatunde. Fashina&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;b&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;a&lt;/sup&gt;Department of Botany, University of Lagos, Akoka, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;b&lt;/sup&gt;Laboratory Services Unit, Nigerian Natural Medicine Development Agency, Lagos Nigeria.&lt;/p&gt;</style></auth-address></record></records></xml>