<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Robert Palomino-De-La-Gala</style></author><author><style face="normal" font="default" size="100%">Hugo Justil-Guerrero</style></author><author><style face="normal" font="default" size="100%">Jorge Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Juan Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Cristian Aguilar-Carranza</style></author><author><style face="normal" font="default" size="100%">Jaime Martínez-Heredia</style></author><author><style face="normal" font="default" size="100%">Edwin Cieza-Macedo</style></author><author><style face="normal" font="default" size="100%">Carlos García-Bustamante</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Edwin Enciso-Roca</style></author><author><style face="normal" font="default" size="100%">Roberto Chávez- Asmat</style></author><author><style face="normal" font="default" size="100%">Lester Dominguez-Huarcaya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Effect of the Ethanolic Extracts of Leaves of Chuquiraga spinosa Less and Baccharis genistelloides on Benign Prostatic Hyperplasia in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Baccharis genistelloides</style></keyword><keyword><style  face="normal" font="default" size="100%">Benign prostatic hyperplasia</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">Dutasteride</style></keyword><keyword><style  face="normal" font="default" size="100%">Testosterone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">858-865</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Benign prostatic hyperplasia (BPH) is one of the most common conditions affecting middle-aged men, with oxidative stress postulated as an important factor in its development.&lt;strong&gt; Objective:&lt;/strong&gt; To evaluate the protective effect of the association of the ethanolic extract of &lt;em&gt;Chuquiraga spinosa &lt;/em&gt;(ChS) and &lt;em&gt;Baccharis genistelloides&lt;/em&gt; (BaG) on benign prostatic hyperplasia in rats. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Sixty-six male rats were randomized into groups: 1) Inductor Group: Testosterone enanthate (ET) 25 mg/Kg on days 8 and 14 intramuscularly. 2) Group P80: Polysorbate-80 3% 10 mL / Kg. 3) Positive Group: ET + Dutasteride (DU) 0.5 mg / Kg, 4) ET + ChS 250, 5) ET + ChS 500, 6) ET + BaG250, 7) ET + BaG 500, 8) ET + ChS 250 + BaG 250, 9) ET + ChS 500 + BaG 500, 10) ET + ChS 250 + BaG 500, 11) ET + ChS 500 + BaG250. PSA, nitric oxide (NO) and malondialdehyde (MDA), prostate dimensions by ultrasound and histopathological findings were quantified as main markers. &lt;strong&gt;Results:&lt;/strong&gt; Lower levels of NO, MDA and PSA were observed in all groups treated with extract compared to the Inductor group (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.01), with the reductive capacity of the mixture ChS 250 + BaG 500 and ChS 500 + BaG 250 compared with Dutasteride (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). The volume of the prostate was lower in the Dutasteride, P80 and ChS250 + BaG500 groups compared to the inducer (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.05). Regarding the histopathological study, it was observed that the association of variable doses (ChS250 + BaG500 and ChS500 + BaG250) had a better protective effect. &lt;strong&gt;Conclusion:&lt;/strong&gt; Under experimental conditions, the association of the extracts of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; and &lt;em&gt;Baccharis genistelloides &lt;/em&gt;has an effect in the protection of BPH induced with testosterone, which could be linked to its antioxidant capacity of the extracts.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">858</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Robert Palomino-De-La- Gala&lt;sup&gt;1,2&lt;/sup&gt;, Hugo Justil-Guerrero&lt;sup&gt;1,2&lt;/sup&gt;, Jorge Arroyo-Acevedo&lt;sup&gt;1,2&lt;/sup&gt;, Juan Rojas-Armas&lt;sup&gt;1,2&lt;/sup&gt;, Cristian Aguilar-Carranza&lt;sup&gt;3&lt;/sup&gt;, Jaime Martínez-Heredia&lt;sup&gt;1,2&lt;/sup&gt;, Edwin Cieza-Macedo&lt;sup&gt;1,2&lt;/sup&gt;, Carlos García- Bustamante&lt;sup&gt;1,2&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;4&lt;/sup&gt;, Edwin Enciso-Roca&lt;sup&gt;5&lt;/sup&gt;, Roberto Chávez- Asmat&lt;sup&gt;6&lt;/sup&gt;, Lester Dominguez-Huarcaya&lt;sup&gt;7&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Institute of Clinical Research, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacology Laboratory, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pathology, Instituto Nacional Cardiovascular, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Association for the Development of Student Research in Health Sciences (ADIECS), Lima, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Physiology laboratory. Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
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