<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Michael Chukwuka Ojo</style></author><author><style face="normal" font="default" size="100%">Foluso Oluwagbemiga Osunsanmi</style></author><author><style face="normal" font="default" size="100%">Godfrey Elijah Zaharare</style></author><author><style face="normal" font="default" size="100%">Rebamang Anthony Mosa</style></author><author><style face="normal" font="default" size="100%">Nkosinathi David Cele</style></author><author><style face="normal" font="default" size="100%">Michael Osawemi Oboh</style></author><author><style face="normal" font="default" size="100%">Andy Rowland Opoku</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In-vitro Anti-diabetic and Antioxidant Efficacy of Methanolic Extract of Encephalartos ferox leaves</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hyperlipidemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Hypoglycaemic</style></keyword><keyword><style  face="normal" font="default" size="100%">Protein- glycation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">455-460</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Diabetes mellitus has been identified as one of the global cause of disability and death. &lt;strong&gt;Objectives:&lt;/strong&gt; The study aim to investigate the &lt;em&gt;in-vitro&lt;/em&gt; antidibetic and antioxidant activities of methanolic extract of &lt;em&gt;Encephalartos ferox&lt;/em&gt; leaves. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The plant was screened for its Phytochemical composition. The plant material was extracted with methanol and the methanolic extract was screened (&lt;em&gt;in-vitro&lt;/em&gt;) for its antioxidant activity using ABTS and DPPH assays. The potential antidiabetic activity of the plant extract was evaluated against some carbohydrates (α- amylase and α-glucosidase) and lipid (pancreatic lipase) digestive enzymes. The inverted intestinal sac model was also used to investigate the effect of the extract on intestinal glucose absorption. The anti-protein glycation activity of the extract was determined using haemoglobin. &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening revealed the presence of most of the phytochemicals (Tannins, Flavonoids, Terpenoids, Alkaloids etc) that were screened for. The crude extract exhibited the antidiabetic potential as it significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt; 0.05) inhibited α-glucosidase and pancreatic lipase in a dose dependent fashion. The extract also effectively reduced intestinal glucose absorption. The extract further showed antioxidant activity by efficiently scavenging ABTS and DPPH radicals with IC&lt;sub&gt;50&lt;/sub&gt; values of 68.3 μg/ml and 308 μg/ml, respectively. The extract also inhibited haemoglobin glycation, thus displaying the anti-protein glycation potential. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is apparent that &lt;em&gt;E. ferox&lt;/em&gt; extract could serve as scaffold for diabetic therapy. For future study, cytotoxicity profile and &lt;em&gt;in vivo&lt;/em&gt; investigation of the antidiabetic activity of the crude extract are essential.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Michael Chukwuka Ojo&lt;sup&gt;1,*&lt;/sup&gt;, Foluso Oluwagbemiga Osunsanmi&lt;sup&gt;2&lt;/sup&gt;, Godfrey Elijah Zaharare&lt;sup&gt;2&lt;/sup&gt;, Rebamang Anthony Mosa&lt;sup&gt;1&lt;/sup&gt;, Nkosinathi David Cele&lt;sup&gt;1&lt;/sup&gt;, Michael Osawemi Oboh&lt;sup&gt;2&lt;/sup&gt;, Andy Rowland Opoku&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&amp;nbsp;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry and Microbiology, University of Zululand, Republic of SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Agricultural Science, University of Zululand, Republic of SOUTH AFRICA.&lt;/p&gt;
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