<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ahmed Muhammad Ibrahim</style></author><author><style face="normal" font="default" size="100%">Hussain Al Sadah</style></author><author><style face="normal" font="default" size="100%">Rizwan Ahmad</style></author><author><style face="normal" font="default" size="100%">Niyaz Ahmad</style></author><author><style face="normal" font="default" size="100%">Atta Abbas Naqvi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Clinical Uses and Toxicity of Aloe vera: An Evidence-Based Comprehensive Retrospective Review (2007-2017)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acemannan</style></keyword><keyword><style  face="normal" font="default" size="100%">Aloe vera</style></keyword><keyword><style  face="normal" font="default" size="100%">Cosmetics</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatitis</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">424-428</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Aloe vera&lt;/em&gt; (AV), mostly known as succulents, or the healing plant of the genus Aloe of &lt;em&gt;Liliaceae&lt;/em&gt; family. It contains large range of vitamins, amino acids, antiseptic, antiinflammatory, and sulfur compounds to control and eliminate mold, bacteria, viruses; however, AV toxicity is most of the times described poorly among AV consumers.&lt;strong&gt; Aim of the Study:&lt;/strong&gt; To report and highlight AV clinical uses and toxicity cases to compare and highlight its therapeutic as well toxic profile. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; AV cases were gathered from databases such as Google Scholar, PubMed, Web of Science, Scopus, and E-Resource Portal of Imam Abdulrahman bin Faisal University using the keywords, i.e., AV case report, AV toxicity, hepatitis, clinical trials about AV, interactions, the current uses of AV, etc. &lt;strong&gt;Results:&lt;/strong&gt; Ten cases met the eligibility criteria where the toxicities were mostly associated with the usage of AV except the intended use, i.e., to be administered topically or AV capsules ingestion or as a drinkable solutions. Major symptoms observed in these cases were related to hepatocytes inflammation (hepatitis), fatigue, nausea, vomiting, thyroid dysfunction, abdominal discomfort, and diarrhea along with severe weight loss. These results were not associated with a specific age; however they were more predominant in female gender. &lt;strong&gt;Conclusion:&lt;/strong&gt; AV should be taken within normal/specified dose range which can only be achieved through asking an herbal specialist, and in approved suitable dosage form which is topical.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">424</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Ahmed Mohammed Aljamea&lt;sup&gt;1&lt;/sup&gt;, Hussain Mazin Alsadah&lt;sup&gt;1&lt;/sup&gt;, Rizwan Ahmad&lt;sup&gt;2*&lt;/sup&gt;, Niyaz Ahmad&lt;sup&gt;3&lt;/sup&gt;, Atta Abbas Naqvi&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Natural Products and Alternative Medicines, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pharmacy practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, SAUDI ARABIA.&lt;/p&gt;
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