<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Boga Gogo Lucien</style></author><author><style face="normal" font="default" size="100%">Bahi Calixte</style></author><author><style face="normal" font="default" size="100%">Yapi Houphouët Félix</style></author><author><style face="normal" font="default" size="100%">N’Guessan Jean David</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Konkon N’Dri Gilles</style></author></secondary-authors><tertiary-authors><author><style face="normal" font="default" size="100%">Djaman Allico Joseph</style></author></tertiary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Assessment of Acute and Subacute Toxicity of the Total Dichloromethane-Ethanol Extract of Morinda morindoides (Baker) Milne-Redh (ETDE) on Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Acute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Damage</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda morindoides</style></keyword><keyword><style  face="normal" font="default" size="100%">Subacute toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Weight gain.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Nov-Dec 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">372-377</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context:&lt;/strong&gt; ETDE shown good antihypertensive and antioxidant activities in rats made hypertensive. This present study aims to assess its toxicity. &lt;strong&gt;Aims:&lt;/strong&gt; This study was designed to study the toxicity of dichloromethaneethanol extract of Morinda morindoides. &lt;strong&gt;Settings and Design:&lt;/strong&gt; Toxicological activity in vivo. &lt;strong&gt;Methods and Material:&lt;/strong&gt; Alkaloids were characterized from reagents of Bouchardat, flavonoids by reacting the cyanidrine, tannins by the reagent Stiasny, polyphenols by reacting ferric chloride, quinones by the reagent Bornstra&amp;euml;gen, sterols and polyterpenes by the reaction of Libermann and saponins by observing the foam after agitation of the extract. Acute and subacute toxicity were studied using respectively 423 and 407 OECD guidelines for testing of chemicals. Statistical analysis used: The graphical representation of the data was performed using the Graph Pad Prism 5.0. The mean value is accompanied by the standard error of the mean (Mean &amp;plusmn; SEM). The difference between the two values is considered significant when P&amp;lt;0.001. Statistical analysis of results was performed using analysis of variance (ANOVA). &lt;strong&gt;Results:&lt;/strong&gt; The phytochemical screening showed the presence in the ETDE of polyphenols, alkaloids, flavonoids, sterols and polyterpenes. The toxicological study shows that ETDE has a LD50 between 2000 and 5000 mg/kg bw therefore classified in the hazard category 5. The administration of ETDE at repeated dose for 28 days did not significantly affect the weight gain, hematological and biochemical parameters of rats. &lt;strong&gt;Conclusion:&lt;/strong&gt; ETDE toxicity is relatively low with LD50 between 2000 and 5000 mg/kg bw. It does not cause damage to the heart, liver and kidney. ETDE can be used without risk of intoxication.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">372</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Boga Gogo Lucien&lt;sup&gt;*1&lt;/sup&gt;, Bahi Calixte&lt;sup&gt;1&lt;/sup&gt;, Konkon N&amp;rsquo;Dri Gilles&lt;sup&gt;2&lt;/sup&gt;, Yapi Houphou&amp;euml;t F&amp;eacute;lix&lt;sup&gt;1&lt;/sup&gt;, Djaman Allico Joseph&lt;sup&gt;1,3&lt;/sup&gt; and N&amp;rsquo;Guessan Jean David&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Biosciences, Biochemical Pharmacodynamy Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. &lt;sup&gt;2&lt;/sup&gt;Department of Biosciences, Botanical Laboratory, University Felix houphou&amp;euml;t-Boigny, Abidjan 22, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa. 3Department of Clinical and Basic Biochemistry, Pasteur Institute of C&amp;ocirc;te d&amp;rsquo;Ivoire, Abidjan 04, C&amp;ocirc;te d&amp;rsquo;Ivoire, Africa&lt;/p&gt;</style></auth-address></record></records></xml>