<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Zulhabri Othman</style></author><author><style face="normal" font="default" size="100%">Hamimi Rasyiqah Hassan Khalep</style></author><author><style face="normal" font="default" size="100%">Azrina Zainal Abidin</style></author><author><style face="normal" font="default" size="100%">Halijah Hassan</style></author><author><style face="normal" font="default" size="100%">Santosh Fattepur</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The Anti-Angiogenic Properties of Morinda citrifolia. L (Mengkudu) Leaves Using Chicken Chorioallantoic Membrane (CAM) Assay</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Chicken Chorioallantoic Membrane (CAM) assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Morinda citrifolia. L leaves</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">White Leghorn eggs</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">12-15</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt; Anti-angiogenesis or inhibition of blood vessel formation is the best way to prevent the growth and metastasis of tumors. The use &lt;em&gt;Morinda citrifolis.&lt;/em&gt; L extracts have been reported to exhibit a broad range of therapeutic effects, including antibacterial and antitumor. Objective: This study aims to investigate the anti-angiogenic properties of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts using Chicken Chorioallantoic Membrane (CAM) assay. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The Fertile White Leghorn eggs were divided into five groups which were control, Bevacizumab drug and treatment groups with 25%, 50% and 75% of &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts respectively. The reduction of the blood vessel was counted after 12 h and 24 h post-treatment. &lt;strong&gt;Results:&lt;/strong&gt; Analysis have shown significant differences (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05) in the reduction of the blood vessel between each group at 24 h post-treatment. The group with 75% extracts showed 37.1% reductions of blood vessel compared to groups 50% and 25% extracts which showed 4% and 12.8% respectively. The phytochemical screening has showed that &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts was positive for flavonoid, phenols and phytosterols. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Morinda citrifolia&lt;/em&gt;. L leaves extracts consist of the phytochemical compounds that have the ability to inhibit the angiogenesis.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">12</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Zulhabri Othman&lt;sup&gt;1,2*&lt;/sup&gt;, Hamimi Rasyiqah Hassan Khalep&lt;sup&gt;1&lt;/sup&gt;, Azrina Zainal Abidin&lt;sup&gt;1&lt;/sup&gt;, Halijah Hassan&lt;sup&gt;1&lt;/sup&gt;, Santosh Fattepur&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;School of Graduate Studies, Post-Graduate Centre, Management and Science University, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Management and Science University, 40100 Shah Alam, Selangor, MALAYSIA.&lt;/p&gt;
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