<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sara Al Ayoubi</style></author><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Abdalla El-Lakany</style></author><author><style face="normal" font="default" size="100%">Maha Aboul-Ela</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Investigation of Psoralea bituminosa L. and its Anti-Diabetic Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">July/2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">73-85</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt;&lt;em&gt;Psoralea bituminosa&lt;/em&gt;L. (Fabaceae), is a very important medicinal plant, used in traditional medicine in Europe, Asia, and America, and in Africa for, its antiseptic, antihyperglycemic and anti-oxidative potentials. The objective of this study is to investigate the potential of&lt;em&gt; Psoralea&lt;/em&gt; &lt;em&gt;bituminosa (Pbt&lt;/em&gt;.) in the management of diabetes and diabetic &amp;ndash; induced thermal hyperalgesia. Moreover, this study aimed also to investigate the volatile oil constituents of &lt;em&gt;Pbt.&lt;/em&gt; growing in Lebanon utilizing GC-MS method. &lt;strong&gt;Methods:&lt;/strong&gt;Blood glucose level (BGL) was measured using gluco-meter while diabetic-induced thermal hyperplasia of &lt;em&gt;Pbt.&lt;/em&gt; growing in Lebanon was measured using tail flick and hot plate methods. Antioxidant was measured using DPPH free radicals method. Volatile oil of fresh and dried aerial parts of &lt;em&gt;Pbt.&lt;/em&gt; was analyzed using GC-MS. &lt;strong&gt;Results:&lt;/strong&gt; The result of study conducted on Lebanese &lt;em&gt;Pbt.&lt;/em&gt; revealed that acute anti-diabetic activity of &lt;em&gt;Pbt.&lt;/em&gt; in the 3 extracts subjected a decrease in BGL ranging between 34% to 38.5%. In subchronic anti-diabetic activity of &lt;em&gt;Pbt.&lt;/em&gt; BGL dropped in range 19% to 44%. Moreover, &lt;em&gt;Pbt.&lt;/em&gt; extract showed 1.7% to 13.6%increase in body weight at all doses with respect to 8th day. On the other hand, alloxan diabetic induced mice reported melioration by 63.8% to 86.3% on the 8th week alloxan after injection in diabetic &amp;ndash; induced thermal hyperalgesia hotplate latency method. Nevertheless, a marked improvement in tail flick latency on the 8th week after alloxan injection by 22.7 % to 48.6 %. &lt;em&gt;Pbt.&lt;/em&gt; extract revealed DPPH radical decreases at 82.6% at concentration of 100 mg/mL, respectively. Total flavonoid content measured of &lt;em&gt;Pbt.&lt;/em&gt; was 135.83 mg/g while total phenolic content showed 217.48 mg/g. &lt;strong&gt;Conclusion:&lt;/strong&gt;&lt;em&gt;Psoralea bituminosa&lt;/em&gt; showed a significant effect in the management of diabetes and neuropathic pain conditions and limiting expected side-effects, which might be used as a future antidiabetic therapy.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Keywords:&lt;/strong&gt;&lt;em&gt;Psoralea bituminosa&lt;/em&gt;,Antidiabetic,Antioxidant,Essential oil,Diabetic neuropathy.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">73</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sara Al Ayoubi, Karim Raafat*,Abdalla El- Lakany,Maha Aboul-Ela &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, Beirut, LEBANON.&lt;/p&gt;</style></auth-address></record></records></xml>