<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Heba Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Mortada Mohamed El-Sayed</style></author><author><style face="normal" font="default" size="100%">Afaf Ahmed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Maher Mahmoud Hashash</style></author><author><style face="normal" font="default" size="100%">Ahmed Mohamed Abdel-Hady</style></author><author><style face="normal" font="default" size="100%">Tarek Aboushousha</style></author><author><style face="normal" font="default" size="100%">El-Sayed Saleh Abdel-Hameed</style></author><author><style face="normal" font="default" size="100%">Ezzat El-Sayed Abdel- Lateef</style></author><author><style face="normal" font="default" size="100%">Eman Abdalla Morsi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Nephroprotective Activity of Methanolic Extract of Lantana camara and Squash (Cucurbita pepo) on Cisplatin-Induced Nephrotoxicity in Rats and Identification of Certain Chemical Constituents of Lantana camara by HPLC-ESI- MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant enzymes</style></keyword><keyword><style  face="normal" font="default" size="100%">Ascorbic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Creatinine</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Histological studies</style></keyword><keyword><style  face="normal" font="default" size="100%">Phenyl etanoid.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/410</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">136-147</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Cisplatin is a highly effective chemotherapeutic agent; its clinical use is severely limited by serious side effects as nephrotoxicity. The aim of this study is to evaluate the nephroprotective activity of defatted methanolic extract of two Egyptian plants: &lt;em&gt;Lantana camara&lt;/em&gt; and &lt;em&gt;Cucurbita pepo&lt;/em&gt; and certain fractions derived from the defatted methanolic extract of L. camara on cisplatin-induced nephrotoxicity in rats. Also, identification of certain chemical constituents of &lt;em&gt;L. camara&lt;/em&gt; by HPLC-ESI- MS. &lt;strong&gt;Methods:&lt;/strong&gt; Nephrotoxicity was induced in rats by single dose of cisplatin. The effect of plants extract at doses 100-400 mg/kg.b.wt comparing with standard; ascorbic acid; was determined using serum urea, creatinine and some ions. Furthermore, the effect of these extracts on some renal antioxidant enzymes and histopathological examination of kidneys were examined. &lt;strong&gt;Results:&lt;/strong&gt; The defatted methanolic extract and ethyl acetate fraction of &lt;em&gt;L. camara&lt;/em&gt; showed the highest improvement of renal parameters. Also, HPLC-ESI-MS analysis of &lt;em&gt;L. camara&lt;/em&gt; extracts exhibited bioactive phenolic compounds including phenyl ethanoid, flavonoids and phenolic acids. &lt;strong&gt;Conclusion:&lt;/strong&gt; The phytochemical constituents of &lt;em&gt;L. camara &lt;/em&gt;are responsible for their nephroprotective activity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Heba Abdel-Hady&lt;sup&gt;1&lt;/sup&gt;*, Mortada Mohamed El-Sayed&lt;sup&gt;1&lt;/sup&gt; , Afaf Ahmed Abdel-Hady&lt;sup&gt;2&lt;/sup&gt;, Maher Mahmoud Hashash&lt;sup&gt;3&lt;/sup&gt;, Ahmed Mohamed Abdel-Hady&lt;sup&gt;4&lt;/sup&gt;, Tarek Aboushousha&lt;sup&gt;4&lt;/sup&gt;, El-Sayed Saleh Abdel-Hameed&lt;sup&gt;1&lt;/sup&gt;, Ezzat El-Sayed Abdel-Lateef&lt;sup&gt;1&lt;/sup&gt;, Eman Abdalla Morsi&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medicinal Chemistry, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;ClinicalChemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry, Faculty of Science, Ain Shams University, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;
&lt;p&gt;&lt;sup&gt;4&lt;/sup&gt;Pathology Department, Theodor Bilharz Research Institute, , Kornish El-Nile Street, Warrak El-Hadar, Imbaba, Giza, EGYPT.&lt;/p&gt;</style></auth-address></record></records></xml>