<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tchaa Kozolina</style></author><author><style face="normal" font="default" size="100%">Poyodi Kola</style></author><author><style face="normal" font="default" size="100%">Diana Obistioiu</style></author><author><style face="normal" font="default" size="100%">Doris Floares</style></author><author><style face="normal" font="default" size="100%">Aboudoulatif Diallo</style></author><author><style face="normal" font="default" size="100%">Batomayena Bakoma</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Polyphenolic Characterization of Aqueous Extract and Comparative Antioxidant and Antibiofilm activities of Xylopia aethiopica Fruit Aqueous and Essential Oil Extracts against Candida Biofilms</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibiofilm</style></keyword><keyword><style  face="normal" font="default" size="100%">crystal violet</style></keyword><keyword><style  face="normal" font="default" size="100%">HPLC-DAD</style></keyword><keyword><style  face="normal" font="default" size="100%">individual polyphenols</style></keyword><keyword><style  face="normal" font="default" size="100%">Xylopia aethiopica</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">358-366</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The increasing resistance of &lt;em&gt;Candida &lt;/em&gt;species to conventional antifungals necessitates the search for new bioactive compounds. &lt;em&gt;Xylopia aethiopica&lt;/em&gt; is a medicinal plant known for its antifungal properties, yet its impact on fungal biofilms remains to be explored. This study characterized the polyphenolic profile of &lt;em&gt;Xylopia aethiopica&lt;/em&gt; hydroethanolic fruit extract and compared the antibiofilm activity of its aqueous extracts and essential oils against &lt;em&gt;Candida &lt;/em&gt;biofilms. &lt;strong&gt;Methodes: &lt;/strong&gt;Total phenols and flavonoids were quantified, and individual compounds were identified via HPLC-DAD. The antioxidant capacity was evaluated by DPPH (2,2-diphenyl-1-pyrylhydrazyl) test. The antibiofilm potential was evaluated using the crystal violet assay to measure biomass reduction and assess the impact on the yeast-tohypha transition. &lt;strong&gt;Results: &lt;/strong&gt;Analyses revealed a rich profile characterized by high yields of epicatechin, phenolic acids, rosmarinic acid, and resveratrol, which impart significant antioxidant properties. In vitro assays demonstrated that among the aqueous extracts, only the hydromethanolic extract (1:2) inhibited biofilms. Conversely, the essential oils exhibited strong dose-dependent efficacy, with hydrodistillation proving superior to steam distillation in restricting the biofilm growth of&lt;em&gt; C. albicans&lt;/em&gt; and &lt;em&gt;C. parapsilosis&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;These findings suggest that &lt;em&gt;Xylopia aethiopica&lt;/em&gt; is a potent source of antibiofilm agents. The essential oil obtained by hydrodistillation represents a promising alternative for eradicating resistant &lt;em&gt;Candida &lt;/em&gt;communities, highlighting the crucial impact of the extraction method on bioactivity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">358</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Tchaa Kozolina&lt;sup&gt;1,3,5*&lt;/sup&gt;, Poyodi Kola&lt;sup&gt;2&lt;/sup&gt;, Diana Obistioiu&lt;sup&gt;3&lt;/sup&gt;, Doris Floares&lt;sup&gt;3&lt;/sup&gt;, Aboudoulatif Diallo&lt;sup&gt;4&lt;/sup&gt;, Batomayena Bakoma&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of pharmaceutical sciences, Faculty of health sciences, Doctoral school ED732-STIS, University of Lome, 01 BP: 1515, Lome, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of applied agronomic and biological sciences (LaSABA), Faculty of sciences and techniques, University of Kara, BP: 404, Kara, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Interdisciplinary research platform, University of life sciences “King Michael I” from Timisoara, Calea Aradului 119, 300645 Timisoara, ROMANIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of pharmacy, Laboratory of pharmacology-toxicology, Faculty of health sciences, University of Lomé, BP: 1515, Lome, TOGO.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of pharmacy, Laboratory of pharmaceutical sciences, Faculty of health sciences, University of Lomé, BP: 1515, Lome, TOGO.&lt;/p&gt;
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