<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pawan Banduji Itankar</style></author><author><style face="normal" font="default" size="100%">Gaurav Rajendra Sawarkar</style></author><author><style face="normal" font="default" size="100%">Ajitkumar Shashikumar Wahane</style></author><author><style face="normal" font="default" size="100%">Anita Santoshrao Wanjari</style></author><author><style face="normal" font="default" size="100%">Ujwal B. Vyas</style></author><author><style face="normal" font="default" size="100%">Punam Gaurav Sawarkar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Histological and Structural Analysis of Wound Healing with Ehretia laevis Roxb. Tincture Ointment versus Povidone-Iodine Ointment in Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ehretia laevis</style></keyword><keyword><style  face="normal" font="default" size="100%">Excision Wound Model</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Povidone-Iodine</style></keyword><keyword><style  face="normal" font="default" size="100%">Preclinical Study</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">279-285</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Delayed wound healing remains a significant clinical challenge, driving the search for effective and safe therapeutic agents. &lt;em&gt;Ehretia laevis&lt;/em&gt; Roxb. is a medicinal plant traditionally used for various ailments, but its wound-healing properties, particularly in a tincture-ointment formulation, have not been systematically investigated. Aim: Structural analysis of wound healing with &lt;em&gt;Ehretia laevis&lt;/em&gt; Roxb. Tincture ointment versus Povidone-iodine ointment in Wistar rats. Methods: An experimental preclinical study was conducted on 12 Wistar rats divided into two groups (n=6 each). A 10 mm diameter full-thickness excision wound was created on the dorsum. Group A received&lt;em&gt; E. laevis&lt;/em&gt; tincture ointment, while Group B received povidone-iodine ointment, twice daily for 15 days. Wound contraction was assessed on days 7 and 15. Histopathological evaluation was performed on days 1, 7, and 15 using a semi-quantitative scoring system for granulation tissue, inflammatory infiltrate, collagen fiber orientation, and collagen deposition. Data were analyzed using unpaired t-tests, two-way ANOVA, and Mann-Whitney U tests. &lt;strong&gt;Results:&lt;/strong&gt; The &lt;em&gt;E. laevis&lt;/em&gt; group exhibited significantly higher mean wound contraction on day 7 (71.5 ± 2.4% vs. 60.5 ± 1.7%; p &amp;lt; 0.0001) and day 15 (97.5 ± 2.4% vs. 90.3 ± 3.0%; p &amp;lt; 0.001) compared to the control group. Histopathological analysis revealed that &lt;em&gt;E. laevis&lt;/em&gt; significantly reduced inflammatory infiltrate (p = 0.045) and promoted early collagen deposition (p = 0.035) by day 7. By day 15, the test group showed significantly superior collagen maturation (p = 0.0037) and orientation (p = 0.014), resulting in significantly higher cumulative healing scores (p = 0.0076). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ehretia laevis&lt;/em&gt; tincture ointment demonstrates superior and accelerated wound healing activity compared to povidone-iodine ointment. Its enhanced efficacy, supported by both macroscopic and histological evidence, positions it as a promising novel therapeutic option for wound management and warrants further investigation into its underlying molecular mechanisms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">279</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pawan Banduji Itankar&lt;sup&gt;1&lt;/sup&gt;, Gaurav Rajendra Sawarkar&lt;sup&gt;2&lt;/sup&gt;, Ajitkumar Shashikumar Wahane&lt;sup&gt;3&lt;/sup&gt;, Anita Santoshrao Wanjari&lt;sup&gt;4&lt;/sup&gt;, Ujwal B. Vyas&lt;sup&gt;5&lt;/sup&gt;, Punam Gaurav Sawarkar&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;PG Scholar, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University) Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor &amp;amp; Head, Department of Rachana Sharir, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Professor, Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Professor, Department of Pharmacology, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Professor, Department of Panchakarma, Mahatma Gandhi Ayurved College Hospital and Research Centre, Datta Meghe Institute of Higher Education and Research (Deemed to be University), Wardha, Maharashtra, INDIA.&lt;/p&gt;
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