<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Yeruult Chultemsuren</style></author><author><style face="normal" font="default" size="100%">Bilegdemberel Khurelbaatar</style></author><author><style face="normal" font="default" size="100%">Chimgee Tserendash</style></author><author><style face="normal" font="default" size="100%">Maral-Erdene Gerelt-Od</style></author><author><style face="normal" font="default" size="100%">Batdavaa Batbayar</style></author><author><style face="normal" font="default" size="100%">Mend-Amar Batbaatar</style></author><author><style face="normal" font="default" size="100%">Perleidulam Bunddulam</style></author><author><style face="normal" font="default" size="100%">Enerel Yeruult</style></author><author><style face="normal" font="default" size="100%">Narankhajid Myadagsuren</style></author><author><style face="normal" font="default" size="100%">Li ChangSheng</style></author><author><style face="normal" font="default" size="100%">Purevjal Otgonbayar</style></author><author><style face="normal" font="default" size="100%">Enkhmaa Gonchig</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuropharmacological Potential of a Combined Herbal Preparation of Valeriana officinalis L. and Leonurus sibiricus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">acute and subchronic toxicity; sedative</style></keyword><keyword><style  face="normal" font="default" size="100%">mice; open-field test; pentylenetetrazole; thiopental sodium</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">252-264</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Neuropsychiatric disorders are a global health burden. The World Health Organization estimates that 264 million individuals experience anxiety, 50 million experience epilepsy, and up to 30% of adults experience insomnia. Despite the high reliance on conventional medicine in developing nations, a critical shortage of scientifically validated herbal formulations for these conditions exists. We aimed to evaluate the neuropharmacological potential of a novel combined herbal preparation (CHP) derived from &lt;em&gt;Valeriana officinalis&lt;/em&gt; L. (roots) and &lt;em&gt;Leonurus sibiricus&lt;/em&gt; L. (aerial parts). &lt;strong&gt;Methods:&lt;/strong&gt; Acute oral toxicity was assessed in C57BL/6 mice. Subchronic toxicity was evaluated in Wistar rats following the Organization for Economic Co-operation and Development guideline 407, with daily oral administration of CHP at doses of 1,000 and 1,500 mg/kg for 28 days. Sedative and locomotor effects were quantified. Hypnotic efficacy was assessed, and anticonvulsant activity was measured against pentylenetetrazole-induced seizures. &lt;strong&gt;Results: &lt;/strong&gt;CHP demonstrated an excellent safety profile with an LD50 of 7,483 mg/kg, classifying it as “practically nontoxic.” No signs of subchronic toxicity were observed. In the open-field test, doses of 750 and 1,000 mg/kg significantly suppressed locomotor activity. The preparation significantly enhanced hypnotic effects by shortening sleep latency and prolonging total sleep duration. Furthermore, CHP exerted notable anticonvulsant activity compared with the control group. &lt;strong&gt;Conclusions: &lt;/strong&gt;Combining&lt;em&gt; V. officinalis&lt;/em&gt; and &lt;em&gt;L. sibiricus&lt;/em&gt; provides a safe and effective botanical synergy with potent sedative, hypnotic, and anticonvulsant properties. Therefore, CHP is a promising therapeutic candidate for managing anxiety, insomnia, and epilepsy, warranting further clinical investigation into its underlying GABAergic or serotonergic mechanisms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">252</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Yeruult Chultemsuren&lt;sup&gt;1&lt;/sup&gt;, Bilegdemberel Khurelbaatar&lt;sup&gt;1&lt;/sup&gt;, Chimgee Tserendash&lt;sup&gt;1&lt;/sup&gt;, Maral-Erdene Gerelt-Od&lt;sup&gt;1&lt;/sup&gt;, Batdavaa Batbayar&lt;sup&gt;1&lt;/sup&gt;, Mend-Amar Batbaatar&lt;sup&gt;1&lt;/sup&gt;, Perleidulam Bunddulam&lt;sup&gt;2&lt;/sup&gt;, Enerel Yeruult&lt;sup&gt;3&lt;/sup&gt;, Narankhajid Myadagsuren&lt;sup&gt;4&lt;/sup&gt;, Li ChangSheng&lt;sup&gt;5&lt;/sup&gt;, Purevjal Otgonbayar&lt;sup&gt;6 *&lt;/sup&gt;, Enkhmaa Gonchig&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar 14210, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Clinical Pharmacy and Management, School of Pharmacy, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;School of Pharmacy, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA. 5Department of Mongolian Medicine Surgery, College of Mongolian Medicine, Inner Mongolia Medical University, China; No&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Xinhua Street, Hohhot, Inner Mongolia Autonomous region, CHINA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Department of Hematology, School of Medicine, Mongolian National University of Medical Sciences, Zorig street, post office 48/111, 14210 Ulaanbaatar, MONGOLIA.&lt;/p&gt;
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