<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Judith M. Bocanegra-Nunez</style></author><author><style face="normal" font="default" size="100%">Deivy Y. Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Walter E. Janampa-Castillo</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of a Cream Based on Hydroalcoholic Extract of Sebastiana Obtusifolia Leaves on Second-Degree Burns in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Burn healing</style></keyword><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Sebastiana obtusifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">216-220</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; (Müll. Arg.), a species belonging to the Euphorbiaceae family, has traditionally been used for medicinal purposes by rural communities due to its medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; Therefore, the objective of this study was to evaluate the effect of a cream based on &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; extract on burns induced in &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c. &lt;strong&gt;Material and methods:&lt;/strong&gt; The experimental animals were divided into 6 groups with 5 specimens each. Forty-eight hours prior to the induction of second-degree burns, the hair was removed from the back area; Ketamine/xylazine 80 mg/kg/-10 mg/ kg was then administered intravenously, and a round metal rod with a diameter of 1.0 cm was placed on the depilated skin at a temperature of 100°C for 5 seconds. Group A received no treatment; Group B was treated with a 1% silver sulfadiazine healing ointment; Group C was treated with a base cream; and the other two groups, D, E, and F, were treated with a cream formulated with &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; at 0.5%, 1%, and 1.5%, respectively. The treatments were administered once a day for 21 days, measuring the burn area and taking the respective photographic controls throughout the experimental period. Euthanasia was then performed using sodium pentobarbital 185 mg/kg i.p. to obtain skin samples, which were preserved in 10% formalin and sent for histopathological analysis. &lt;strong&gt;Results:&lt;/strong&gt; There was a statistically significant difference between the groups, with a significance level of p&amp;lt;0.05 during the experiment. Histopathological sections showed that in groups D and F there was an abundance of collagen and fibroblasts in the direction of the dermis, attributable to the effect of the creams. &lt;strong&gt;Conclusion:&lt;/strong&gt; Creams based on hydroalcoholic extract of &lt;em&gt;Sebastiana obtusifolia&lt;/em&gt; “lloque blanco” have a healing effect on seconddegree burns induced in &lt;em&gt;Mus musculus&lt;/em&gt; Balb/c, with the greatest effect being observed with the 1.5% cream.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">216</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Judith M. Bocanegra-Núñez&lt;sup&gt;1&lt;/sup&gt;, Deivy Y. Dionicio-Rosado&lt;sup&gt;2&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;3&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;4&lt;/sup&gt;, Walter E. Janampa-Castillo&lt;sup&gt;5&lt;/sup&gt;, Abhel A. Calderón-Peña&lt;sup&gt;6&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Ingeniería, Universidad Nacional Ciro Alegría, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Gestión Empresarial, Universidad Nacional Ciro Alegría. PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias de la Educación y de la Comunicación, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
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