<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Harry Kurniawan Gondo</style></author><author><style face="normal" font="default" size="100%">Elizabeth Haryanti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ciplukan Fruit Extract (Physalis angulata L.) on IL-12 and Oxidative Stress in Mice Gestational Diabetes Mellitus</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Ciplukan fruit extract</style></keyword><keyword><style  face="normal" font="default" size="100%">DMG</style></keyword><keyword><style  face="normal" font="default" size="100%">IL-12</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA</style></keyword><keyword><style  face="normal" font="default" size="100%">SOD</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1121-1123</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Gestational diabetes mellitus (GDM) is a common pregnancy complication, characterized by increased blood glucose levels that occur during pregnancy. Oxidative stress in hyperglycemia increases the inflammatory response in GDM by stimulating pro-inflammatory genes. IL-12 is a pro-inflammatory cytokine that is generally involved in inflammatory responses . This research aims to determine the effect of ciplukan fruit extract against IL-12, and Oxidative Stress in Gestational Diabetes Mellitus mice . The method used in this research is RAL (Completely Randomized Design). Analysis of cytokine levels using the ELISA reading method was followed by data analysis using the ANOVA test . The results showed that the treatment given gradually increased the highest cytokine levels in the P4 group showing the highest increase with IL-12 levels of 0.246 pg/mL, SOD of 0.160 U/mg protein, and MDA of 0.070 μmol/L. In this study it can be concluded that the P4 group showed the strongest effect in all parameters, indicating the potential of the agent or intervention as an immunomodulator and antioxidant, although it requires good management of oxidative stress.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1121</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Harry Kurniawan Gondo*, Elizabeth Haryanti&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Medicine, Wijaya Kusuma University, Surabaya, INDONESIA.&lt;/p&gt;
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